Cd97

Summary

Gene Symbol: Cd97
Description: CD97 antigen
Alias: AA409984, TM7LN1, EGF-TM7 receptor
Species: mouse

Top Publications

  1. doi Deletion of either CD55 or CD97 ameliorates arthritis in mouse models
    Robert M Hoek
    Academic Medical Center, Amsterdam, The Netherlands
    Arthritis Rheum 62:1036-42. 2010
  2. doi CD97 is differentially expressed on murine hematopoietic stem-and progenitor-cells
    Melissa van Pel
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Haematologica 93:1137-44. 2008
  3. pmc Structural characterization of mouse CD97 and study of its specific interaction with the murine decay-accelerating factor (DAF, CD55)
    Y M Qian
    Center for Experimental Therapeutics and Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Immunology 98:303-11. 1999
  4. ncbi The EGF-TM7 family: a postgenomic view
    Mark J Kwakkenbos
    Laboratory for Experimental Immunology, Academic Medical Center, University of Amsterdam, G1 106, PO Box 22700, 1100 DE, Amsterdam, The Netherlands
    Immunogenetics 55:655-66. 2004
  5. ncbi The epidermal growth factor-seven transmembrane (EGF-TM7) receptor CD97 is required for neutrophil migration and host defense
    Jaklien C Leemans
    Laboratory for Experimental Internal Medicine, Department of Pathology, Academic Medical Center, University of Amsterdam, 1100 DE Amsterdam, The Netherlands
    J Immunol 172:1125-31. 2004
  6. pmc Improved antibacterial host defense and altered peripheral granulocyte homeostasis in mice lacking the adhesion class G protein receptor CD97
    Tao Wang
    Cell and Cancer Biology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Infect Immun 75:1144-53. 2007
  7. ncbi Molecular cloning and characterization of mouse CD97
    J Hamann
    Department of Immunobiology, CLB and Laboratory for Experimental and Clinical Immunology, Academic Medical Centre, University of Amsterdam, Plesmanlaan 125, 1066 CX Amsterdam, The Netherlands
    Int Immunol 12:439-48. 2000
  8. ncbi Analysis of CD97 expression and manipulation: antibody treatment but not gene targeting curtails granulocyte migration
    Henrike Veninga
    Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Immunol 181:6574-83. 2008
  9. doi Shear stress-dependent downregulation of the adhesion-G protein-coupled receptor CD97 on circulating leukocytes upon contact with its ligand CD55
    Olga N Karpus
    Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    J Immunol 190:3740-8. 2013
  10. doi Therapeutic antibody targeting of CD97 in experimental arthritis: the role of antigen expression, shedding, and internalization on the pharmacokinetics of anti-CD97 monoclonal antibody 1B2
    Dorien M de Groot
    Schering Plough Research Institute, Oss, The Netherlands
    J Immunol 183:4127-34. 2009

Scientific Experts

  • Robert M Hoek
  • Henrike Veninga
  • Jörg Hamann
  • Melissa van Pel
  • Olga N Karpus
  • Mark J Kwakkenbos
  • Susann Becker
  • Dorien M de Groot
  • Rene A W van Lier
  • Henny Hagoort
  • Willem E Fibbe
  • Tao Wang
  • J Hamann
  • Jaklien C Leemans
  • Jaap D van Buul
  • Dennis Flierman
  • Kris A Reedquist
  • Ed Vanbavel
  • M Edward Medof
  • Corianne C Vandenakker
  • Elke Wandel
  • Gabriela Aust
  • Rick Schneider
  • Christiane Kerner
  • Manja Wobus
  • Salah Amasheh
  • Joerg Hamann
  • Doreen Sittig
  • Ronald Naumann
  • John Dulos
  • Karin Stebbins
  • Annemieke M Boots
  • Gerard Vogel
  • Hans Van Eenennaam
  • Ebo Bos
  • Bronwyn M Owens
  • Leonie Teeuwen
  • E A Carver
  • Y M Qian
  • Philip M Murphy
  • Ulrich Siebenlist
  • Linhua Tian
  • Kathleen Kelly
  • Ross Lake
  • Yvona Ward
  • Hongshan Wang
  • Ji Liang Gao
  • Makoto Haino
  • Else N Kop
  • Sandrine Florquin
  • Anje A te Velde
  • Martin Stacey
  • Hsi Hsien Lin
  • Siamon Gordon
  • Tom van der Poll
  • Kora de Bruin
  • Mourad Matmati
  • Roelof J Bennink
  • A Bijl
  • R A van Lier
  • C van Zeventer
  • K Tesselaar
  • C Molenaar
  • K Kelly
  • A S Olsen
  • L Stubbs
  • M Haino
  • W C Song

Detail Information

Publications14

  1. doi Deletion of either CD55 or CD97 ameliorates arthritis in mouse models
    Robert M Hoek
    Academic Medical Center, Amsterdam, The Netherlands
    Arthritis Rheum 62:1036-42. 2010
    ..abundantly present on fibroblast-like synoviocytes and is also a ligand of the adhesion-class heptahelical receptor CD97, which is expressed by infiltrating macrophages...
  2. doi CD97 is differentially expressed on murine hematopoietic stem-and progenitor-cells
    Melissa van Pel
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Haematologica 93:1137-44. 2008
    b>CD97 is a member of the epidermal growth factor-seven transmembrane (EGF-TM7) family of adhesion receptors and is broadly expressed on hematopoietic cells...
  3. pmc Structural characterization of mouse CD97 and study of its specific interaction with the murine decay-accelerating factor (DAF, CD55)
    Y M Qian
    Center for Experimental Therapeutics and Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Immunology 98:303-11. 1999
    b>CD97 is a newly identified, activation-associated human leucocyte antigen with seven putative transmembrane domains...
  4. ncbi The EGF-TM7 family: a postgenomic view
    Mark J Kwakkenbos
    Laboratory for Experimental Immunology, Academic Medical Center, University of Amsterdam, G1 106, PO Box 22700, 1100 DE, Amsterdam, The Netherlands
    Immunogenetics 55:655-66. 2004
    ..Recent in vivo studies demonstrate a role of the EGF-TM7 receptor CD97 in leukocyte migration...
  5. ncbi The epidermal growth factor-seven transmembrane (EGF-TM7) receptor CD97 is required for neutrophil migration and host defense
    Jaklien C Leemans
    Laboratory for Experimental Internal Medicine, Department of Pathology, Academic Medical Center, University of Amsterdam, 1100 DE Amsterdam, The Netherlands
    J Immunol 172:1125-31. 2004
    ..Family members CD97, EGF module-containing mucin-like receptor (EMR) 1, EMR2, EMR3, EMR4, and EGF-TM7-latrophilin-related protein are ..
  6. pmc Improved antibacterial host defense and altered peripheral granulocyte homeostasis in mice lacking the adhesion class G protein receptor CD97
    Tao Wang
    Cell and Cancer Biology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Infect Immun 75:1144-53. 2007
    b>CD97 is a member of the adhesion family of G protein-coupled receptors. Alternatively spliced forms of CD97 bind integrins alpha5beta1 and alphavbeta3, decay accelerating factor, or dermatan sulfate...
  7. ncbi Molecular cloning and characterization of mouse CD97
    J Hamann
    Department of Immunobiology, CLB and Laboratory for Experimental and Clinical Immunology, Academic Medical Centre, University of Amsterdam, Plesmanlaan 125, 1066 CX Amsterdam, The Netherlands
    Int Immunol 12:439-48. 2000
    The EGF-TM7 family (CD97 and EMR1) is a group of class II seven-span transmembrane receptors predominantly expressed by cells of the immune system...
  8. ncbi Analysis of CD97 expression and manipulation: antibody treatment but not gene targeting curtails granulocyte migration
    Henrike Veninga
    Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Immunol 181:6574-83. 2008
    The heptahelical receptor CD97 is a defining member of the EGF-TM7 family of adhesion class receptors...
  9. doi Shear stress-dependent downregulation of the adhesion-G protein-coupled receptor CD97 on circulating leukocytes upon contact with its ligand CD55
    Olga N Karpus
    Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    J Immunol 190:3740-8. 2013
    ..In this study, we investigated the interaction between the pan-leukocyte aGPCR CD97 and its ligand CD55...
  10. doi Therapeutic antibody targeting of CD97 in experimental arthritis: the role of antigen expression, shedding, and internalization on the pharmacokinetics of anti-CD97 monoclonal antibody 1B2
    Dorien M de Groot
    Schering Plough Research Institute, Oss, The Netherlands
    J Immunol 183:4127-34. 2009
    b>CD97 is a member of the EGF-TM7 family of adhesion class receptors, with a proposed role in inflammatory cell recruitment...
  11. pmc Overexpression of CD97 in intestinal epithelial cells of transgenic mice attenuates colitis by strengthening adherens junctions
    Susann Becker
    Research Laboratories, Department of Surgery, University of Leipzig, Leipzig, Germany
    PLoS ONE 5:e8507. 2010
    The adhesion G-protein-coupled receptor CD97 is present in normal colonic enterocytes but overexpressed in colorectal carcinoma...
  12. doi Differential role of CD97 in interleukin-8-induced and granulocyte-colony stimulating factor-induced hematopoietic stem and progenitor cell mobilization
    Melissa van Pel
    Department of Immunohematology and Bloodtransfusion, Leiden University Medical Center, E3 Q, P O Box 9600, 2300 RC Leiden, The Netherlands
    Haematologica 93:601-4. 2008
    b>CD97 is broadly expressed on hematopoietic cells and is involved in neutrophil migration...
  13. pmc A novel role for CD55 in granulocyte homeostasis and anti-bacterial host defense
    Henrike Veninga
    Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 6:e24431. 2011
    In addition to its complement-regulating activity, CD55 is a ligand of the adhesion class G protein-coupled receptor CD97; however, the relevance of this interaction has remained elusive...
  14. ncbi Physical mapping of EMR1 and CD97 in human Chromosome 19 and assignment of Cd97 to mouse Chromosome 8 suggest an ancient genomic duplication
    E A Carver
    Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, P O Box 808, L 452, Livermore, California 94550, USA
    Mamm Genome 10:1039-40. 1999