Gene Symbol: Cd9
Description: CD9 antigen
Alias: Tspan29, CD9 antigen
Species: mouse
Products:     Cd9

Top Publications

  1. Suzuki M, Tachibana I, Takeda Y, He P, Minami S, Iwasaki T, et al. Tetraspanin CD9 negatively regulates lipopolysaccharide-induced macrophage activation and lung inflammation. J Immunol. 2009;182:6485-93 pubmed publisher
    ..In the present study, the role of tetraspanin CD9 in LPS-induced macrophage activation and lung inflammation was investigated in vitro and in vivo...
  2. Kaji K, Oda S, Shikano T, Ohnuki T, Uematsu Y, Sakagami J, et al. The gamete fusion process is defective in eggs of Cd9-deficient mice. Nat Genet. 2000;24:279-82 pubmed
    The cell-surface molecule Cd9, a member of the transmembrane-4 superfamily, interacts with the integrin family and other membrane proteins. and is postulated to participate in cell migration and adhesion...
  3. Zhu X, Evans J. Analysis of the roles of RGD-binding integrins, alpha(4)/alpha(9) integrins, alpha(6) integrins, and CD9 in the interaction of the fertilin beta (ADAM2) disintegrin domain with the mouse egg membrane. Biol Reprod. 2002;66:1193-202 pubmed
    ..An antibody to the integrin-associated tetraspanin protein CD9 inhibits the binding of a multivalent presentation of fertilin beta (immobilized on beads) but not soluble fertilin ..
  4. Kaji K, Oda S, Miyazaki S, Kudo A. Infertility of CD9-deficient mouse eggs is reversed by mouse CD9, human CD9, or mouse CD81; polyadenylated mRNA injection developed for molecular analysis of sperm-egg fusion. Dev Biol. 2002;247:327-34 pubmed
    b>CD9 is a membrane protein belonging to the tetraspanin family...
  5. Le Naour F, Rubinstein E, Jasmin C, Prenant M, Boucheix C. Severely reduced female fertility in CD9-deficient mice. Science. 2000;287:319-21 pubmed
    b>CD9 is a widely expressed cell surface molecule that belongs to the tetraspanin superfamily of proteins...
  6. Miyado K, Yoshida K, Yamagata K, Sakakibara K, Okabe M, Wang X, et al. The fusing ability of sperm is bestowed by CD9-containing vesicles released from eggs in mice. Proc Natl Acad Sci U S A. 2008;105:12921-6 pubmed publisher
    ..However, aside from the involvement of two molecules, CD9 and Izumo, the mechanism of fusion remains unclear...
  7. Takeda Y, He P, Tachibana I, Zhou B, Miyado K, Kaneko H, et al. Double deficiency of tetraspanins CD9 and CD81 alters cell motility and protease production of macrophages and causes chronic obstructive pulmonary disease-like phenotype in mice. J Biol Chem. 2008;283:26089-97 pubmed publisher
    b>CD9 and CD81 are closely related tetraspanins that regulate cell motility and signaling by facilitating the organization of multimolecular membrane complexes, including integrins...
  8. Miyado K, Yamada G, Yamada S, Hasuwa H, Nakamura Y, Ryu F, et al. Requirement of CD9 on the egg plasma membrane for fertilization. Science. 2000;287:321-4 pubmed
    b>CD9 is an integral membrane protein associated with integrins and other membrane proteins. Mice lacking CD9 were produced by homologous recombination. Both male and female CD9-/- mice were born healthy and grew normally...
  9. Wang X, Alfaro M, Evans G, Zuckerman S. Histone deacetylase inhibition results in decreased macrophage CD9 expression. Biochem Biophys Res Commun. 2002;294:660-6 pubmed
    ..In the present study the effects of the HDAC inhibitor trichostatin A (TSA) on the tetraspanin cell surface antigen CD9 were determined in primary murine macrophages...

More Information


  1. Waterhouse R, Ha C, Dveksler G. Murine CD9 is the receptor for pregnancy-specific glycoprotein 17. J Exp Med. 2002;195:277-82 pubmed
    ..7 cell cDNA expression library. The PSG17 receptor was identified as the tetraspanin, CD9. We confirmed binding of PSG17 to CD9 by ELISA, flow cytometry, alkaline phosphatase binding assays, and in situ ..
  2. Takeda Y, Tachibana I, Miyado K, Kobayashi M, Miyazaki T, Funakoshi T, et al. Tetraspanins CD9 and CD81 function to prevent the fusion of mononuclear phagocytes. J Cell Biol. 2003;161:945-56 pubmed
    Tetraspanins CD9 and CD81 facilitate the fusion between gametes, myoblasts, or virus-infected cells. Here, we investigated the role of these tetraspanins in the fusion of mononuclear phagocytes...
  3. Wynne F, Ball M, McLellan A, Dockery P, Zimmermann W, Moore T. Mouse pregnancy-specific glycoproteins: tissue-specific expression and evidence of association with maternal vasculature. Reproduction. 2006;131:721-32 pubmed
    ..The only Psg receptor identified is CD9, through which Psg17 induces cytokine production from macrophages cultured in vitro...
  4. Copeland B, Bowman M, Boucheix C, Ashman L. Knockout of the tetraspanin Cd9 in the TRAMP model of de novo prostate cancer increases spontaneous metastases in an organ-specific manner. Int J Cancer. 2013;133:1803-12 pubmed publisher
    ..Clinical studies have mostly shown that reduced expression levels of the tetraspanin CD9 are correlated with tumour progression in a range of cancers...
  5. Sumiyoshi N, Ishitobi H, Miyaki S, Miyado K, Adachi N, Ochi M. The role of tetraspanin CD9 in osteoarthritis using three different mouse models. Biomed Res. 2016;37:283-291 pubmed
    ..b>CD9, a member of the tetraspanin family, is localized in the cell membranes and partly in the endosomes of all ..
  6. Inoue N, Nishikawa T, Ikawa M, Okabe M. Tetraspanin-interacting protein IGSF8 is dispensable for mouse fertility. Fertil Steril. 2012;98:465-70 pubmed publisher
    ..Experimental prospective study. Academic basic research laboratory. C57BL/6J and hybrid B6D2F1 mice, as well as Cd9 and Igsf8 knockout mice (C57BL/6J and 129/SvJ mix background), were used for this study. None...
  7. Colino J, Snapper C. Dendritic cell-derived exosomes express a Streptococcus pneumoniae capsular polysaccharide type 14 cross-reactive antigen that induces protective immunoglobulin responses against pneumococcal infection in mice. Infect Immun. 2007;75:220-30 pubmed
    ..Although anti-Cps14 Ig responses are specifically demonstrated, these could reflect a broader mechanism that modulates both natural immunity and autoimmunity to other glycotopes. ..
  8. Higashiyama S, Nanba D. ADAM-mediated ectodomain shedding of HB-EGF in receptor cross-talk. Biochim Biophys Acta. 2005;1751:110-7 pubmed
    ..Here we focus on the ectodomain shedding of HB-EGF by ADAMs, which is not only a key event of receptor cross-talk but also a novel intercellular signaling by the carboxy-terminal fragment (CTF signal). ..
  9. Segura E, Kapp E, Gupta N, Wong J, Lim J, Ji H, et al. Differential expression of pathogen-recognition molecules between dendritic cell subsets revealed by plasma membrane proteomic analysis. Mol Immunol. 2010;47:1765-73 pubmed publisher
    ..This analysis provides major advantages over genomic approaches as it directly measures protein expression at a particular location. Our study highlights the diversity of surface protein expression amongst components of the DC network. ..
  10. Terada N, Baracskay K, Kinter M, Melrose S, Brophy P, Boucheix C, et al. The tetraspanin protein, CD9, is expressed by progenitor cells committed to oligodendrogenesis and is linked to beta1 integrin, CD81, and Tspan-2. Glia. 2002;40:350-9 pubmed
    Previous studies identified the tetraspanin protein CD9 in myelinating oligodendrocytes...
  11. Kawano N, Miyado K, Yoshii N, Kanai S, Saito H, Miyado M, et al. Absence of CD9 reduces endometrial VEGF secretion and impairs uterine repair after parturition. Sci Rep. 2014;4:4701 pubmed publisher
    ..In mammals, uterine epithelium is remodeled cyclically throughout adult life for pregnancy. Despite the expression of CD9 in the uterine epithelium, its role in maternal reproduction is unclear...
  12. Ha S, Tsuji M, Suzuki K, Meek B, Yasuda N, Kaisho T, et al. Regulation of B1 cell migration by signals through Toll-like receptors. J Exp Med. 2006;203:2541-50 pubmed
    ..signals through Toll-like receptors (TLRs) induce specific, rapid, and transient down-regulation of integrins and CD9 on B1 cells, which is required for detachment from local matrix and a high velocity movement of cells in response ..
  13. Ishii M, Iwai K, Koike M, Ohshima S, Kudo Tanaka E, Ishii T, et al. RANKL-induced expression of tetraspanin CD9 in lipid raft membrane microdomain is essential for cell fusion during osteoclastogenesis. J Bone Miner Res. 2006;21:965-76 pubmed
    We showed that CD9, a member of tetraspanin superfamily proteins, is expressed in a specific membrane microdomain, called "lipid raft," and is crucial for cell fusion during osteoclastogenesis after activation of the RANK/RANKL ..
  14. Ovalle S, Gutierrez Lopez M, Olmo N, Turnay J, Lizarbe M, Majano P, et al. The tetraspanin CD9 inhibits the proliferation and tumorigenicity of human colon carcinoma cells. Int J Cancer. 2007;121:2140-52 pubmed
    The implication of the tetraspanin CD9 in cancer has received much recent attention and an inverse correlation between CD9 expression and the metastatic potential and cancer survival rate has been established for different tumor types...
  15. Cariappa A, Shoham T, Liu H, Levy S, Boucheix C, Pillai S. The CD9 tetraspanin is not required for the development of peripheral B cells or for humoral immunity. J Immunol. 2005;175:2925-30 pubmed
    The CD9 tetraspanin is known to be expressed at high levels on marginal zone (MZ) B cells, B-1 B cells, and plasma cells, and its expression is believed to be dependent on signals derived via Btk...
  16. Seldin M, Rochelle J, Tomlinson M, Wright M. Mapping of the genes for four members of the transmembrane 4 superfamily: mouse Cd9, Cd63, Cd81, and Cd82. Immunogenetics. 1995;42:422-5 pubmed
  17. Shoham T, Rajapaksa R, Boucheix C, Rubinstein E, Poe J, Tedder T, et al. The tetraspanin CD81 regulates the expression of CD19 during B cell development in a postendoplasmic reticulum compartment. J Immunol. 2003;171:4062-72 pubmed
    ..The dependence of CD19 expression on CD81 is specific to this particular tetraspanin since cd9(-/-) B cells express normal levels of CD19...
  18. Akutsu H, Miura T, Machida M, Birumachi J, Hamada A, Yamada M, et al. Maintenance of pluripotency and self-renewal ability of mouse embryonic stem cells in the absence of tetraspanin CD9. Differentiation. 2009;78:137-42 pubmed publisher
    We have previously demonstrated that the tetraspanin CD9 is necessary for membrane fusion between sperm and oocyte during fertilization...
  19. Blumenthal A, Giebel J, Warsow G, Li L, Ummanni R, Schordan S, et al. Mechanical stress enhances CD9 expression in cultured podocytes. Am J Physiol Renal Physiol. 2015;308:F602-13 pubmed publisher
    ..We found that tetraspanin CD9 is significantly upregulated in cultured podocytes after mechanical stress...
  20. Yamashita M, Honda A, Ogura A, Kashiwabara S, Fukami K, Baba T. Reduced fertility of mouse epididymal sperm lacking Prss21/Tesp5 is rescued by sperm exposure to uterine microenvironment. Genes Cells. 2008;13:1001-13 pubmed publisher
    ..These data suggest the physiological importance of sperm transport through the uterus. ..
  21. Youn B, Jang I, Broxmeyer H, Cooper S, Jenkins N, Gilbert D, et al. A novel chemokine, macrophage inflammatory protein-related protein-2, inhibits colony formation of bone marrow myeloid progenitors. J Immunol. 1995;155:2661-7 pubmed
  22. Iwasaki T, Takeda Y, Maruyama K, Yokosaki Y, Tsujino K, Tetsumoto S, et al. Deletion of tetraspanin CD9 diminishes lymphangiogenesis in vivo and in vitro. J Biol Chem. 2013;288:2118-31 pubmed publisher lymph nodes was diminished and accompanied by decreased angiogenesis and lymphangiogenesis in tetraspanin CD9-KO mice...
  23. Inoue N, Hamada D, Kamikubo H, Hirata K, Kataoka M, Yamamoto M, et al. Molecular dissection of IZUMO1, a sperm protein essential for sperm-egg fusion. Development. 2013;140:3221-9 pubmed publisher
    ..Gene disruption studies have showed that IZUMO1 on spermatozoon and CD9 on oocyte are essential transmembrane proteins in sperm-egg fusion...
  24. Scherberich A, Giannone G, Perennou E, Takeda K, Boucheix C, Rubinstein E, et al. FAK-mediated inhibition of vascular smooth muscle cell migration by the tetraspanin CD9. Thromb Haemost. 2002;87:1043-50 pubmed
    ..We investigated a potential role for the tetraspanin CD9 in this process in a wound migration assay...
  25. Heit B, Kim H, Cosio G, Castaño D, Collins R, Lowell C, et al. Multimolecular signaling complexes enable Syk-mediated signaling of CD36 internalization. Dev Cell. 2013;24:372-83 pubmed publisher
    ..internalization through a heteromeric complex consisting of CD36, ?1 and/or ?2 integrins, and the tetraspanins CD9 and/or CD81...
  26. de Bruyne E, Andersen T, De Raeve H, Van Valckenborgh E, Caers J, Van Camp B, et al. Endothelial cell-driven regulation of CD9 or motility-related protein-1 expression in multiple myeloma cells within the murine 5T33MM model and myeloma patients. Leukemia. 2006;20:1870-9 pubmed
    The cell surface expression of CD9, a glycoprotein of the tetraspanin family influencing several processes including cell motility and metastasis, inversely correlates with progression in several solid tumors...
  27. Kobayashi T. Molecular cloning and characterization of chick CD9. Kurume Med J. 2000;47:151-7 pubmed
    b>CD9 is a tetra-membrane-spanning glycoprotein involved in cell adhesion, migration, growth signaling and tumor cell metastasis. In this study a CD9 cDNA clone has been isolated from chick cDNA library...
  28. Mulrooney J, Allen J, Bickelhaupt E, Grabel L. CD9-alpha6beta1 interactions in migratory parietal endoderm cells. Cell Commun Adhes. 2002;9:249-58 pubmed
    ..We show here that the tetraspanin CD9 preferentially coimmunoprecipitates with the alpha6beta1 integrin heterodimer in F9-derived parietal endoderm cells ..
  29. He Z, Gupta S, Myles D, Primakoff P. Loss of surface EWI-2 on CD9 null oocytes. Mol Reprod Dev. 2009;76:629-36 pubmed publisher
    b>CD9, a member of the tetraspanin family, associates with a variety of other proteins to form the tetraspanin web. CD9 forms direct and relatively stable associations with the immunoglobulin superfamily proteins EWI-2 and EWI-F...
  30. Chang Y, Finnemann S. Tetraspanin CD81 is required for the alpha v beta5-integrin-dependent particle-binding step of RPE phagocytosis. J Cell Sci. 2007;120:3053-63 pubmed
    ..Here, we show that tetraspanins CD81 and CD9 reside in a complex specifically with alpha v beta5 integrin but not the engulfment receptors Mer tyrosine kinase ..
  31. Kagawa T, Mekada E, Shishido Y, Ikenaka K. Immune system-related CD9 is expressed in mouse central nervous system myelin at a very late stage of myelination. J Neurosci Res. 1997;50:312-20 pubmed
    b>CD9 is a tetra-membrane-spanning glycoprotein involved in cell adhesion, migration, and proliferation in both the immune and the immature nervous system...
  32. Ray A, Treloar H. IgSF8: a developmentally and functionally regulated cell adhesion molecule in olfactory sensory neuron axons and synapses. Mol Cell Neurosci. 2012;50:238-49 pubmed publisher
    ..Immunoprecipitations indicate that IgSF8 interacts with tetraspanin CD9 in the olfactory bulb (OB)...
  33. Yi T, Kim H, Cho J, Woo K, Ryoo H, Kim G, et al. Tetraspanin CD9 regulates osteoclastogenesis via regulation of p44/42 MAPK activity. Biochem Biophys Res Commun. 2006;347:178-84 pubmed
    Tetraspanin CD9 has been shown to regulate cell-cell fusion in sperm-egg fusion and myotube formation. However, the role of CD9 in osteoclast, another multinucleated cell type, is not still clear...
  34. Charrin S, Latil M, Soave S, Polesskaya A, Chretien F, Boucheix C, et al. Normal muscle regeneration requires tight control of muscle cell fusion by tetraspanins CD9 and CD81. Nat Commun. 2013;4:1674 pubmed publisher
    ..Here we show that muscle regeneration in mice lacking either CD9 or CD81 is abnormal and characterized by the formation of discrete giant dystrophic myofibres, which form more ..
  35. Romand R, Ripp R, Poidevin L, Boeglin M, Geffers L, Dollé P, et al. Integrated annotation and analysis of in situ hybridization images using the ImAnno system: application to the ear and sensory organs of the fetal mouse. PLoS ONE. 2015;10:e0118024 pubmed publisher
    ..These analyses exemplify an under-represention of "sensory" functions in the sensory gene set suggests that E14.5 is a pivotal stage between the developmental stage and the functional phase that will be fully reached only after birth. ..
  36. Barraud Lange V, Chalas Boissonnas C, Serres C, Auer J, Schmitt A, Lefevre B, et al. Membrane transfer from oocyte to sperm occurs in two CD9-independent ways that do not supply the fertilising ability of Cd9-deleted oocytes. Reproduction. 2012;144:53-66 pubmed publisher
    ..Although CD9 tetraspanin is an essential molecule for fertilisation, exosome and trogocytosis transfer persists in Cd9-null ..
  37. Runge K, Evans J, He Z, Gupta S, McDonald K, Stahlberg H, et al. Oocyte CD9 is enriched on the microvillar membrane and required for normal microvillar shape and distribution. Dev Biol. 2007;304:317-25 pubmed
    ..b>CD9 is currently the only oocyte protein known to be required for sperm-oocyte fusion...
  38. Toyo oka K, Tai X, Yashiro Y, Ahn H, Abe R, Hamaoka T, et al. Synergy between CD28 and CD9 costimulation for naive T-cell activation. Immunol Lett. 1997;58:19-23 pubmed
    Our previous study demonstrated that CD9 is expressed on most mature naive T-cells and delivers a potent costimulatory signal that functions independently of CD28...
  39. Silvie O, Rubinstein E, Franetich J, Prenant M, Belnoue E, Renia L, et al. Hepatocyte CD81 is required for Plasmodium falciparum and Plasmodium yoelii sporozoite infectivity. Nat Med. 2003;9:93-6 pubmed
    ..We further demonstrate that the requirement for CD81 is linked to sporozoite entry into hepatocytes by formation of a parasitophorous vacuole, which is essential for parasite differentiation into exoerythrocytic forms. ..
  40. Glazar A, Evans J. Immunoglobulin superfamily member IgSF8 (EWI-2) and CD9 in fertilisation: evidence of distinct functions for CD9 and a CD9-associated protein in mammalian sperm-egg interaction. Reprod Fertil Dev. 2009;21:293-303 pubmed
    On the mouse egg, the tetraspanin CD9 is nearly essential for sperm-egg fusion, with another tetraspanin, CD81, playing a complementary role...
  41. Fan J, Zhu G, Niles R. Expression and function of CD9 in melanoma cells. Mol Carcinog. 2010;49:85-93 pubmed publisher
    b>CD9, a member of the tetraspanin family, functions as an organizer in "tetraspanin webs," through interacting with other cell adhesion molecules. It plays a role in differentiation, fertilization, and cell migration...
  42. Balch S, McKnight A, Seldin M, Gordon S. Cloning of a novel C-type lectin expressed by murine macrophages. J Biol Chem. 1998;273:18656-64 pubmed
    ..The mcl gene locus has been mapped between the genes for the interleukin-17 receptor and CD4 on mouse chromosome 6, the same chromosome as the mouse natural killer cell gene complex. ..
  43. Yamane H, Tachibana I, Takeda Y, Saito Y, Tamura Y, He P, et al. Propionibacterium acnes-induced hepatic granuloma formation is impaired in mice lacking tetraspanin CD9. J Pathol. 2005;206:486-92 pubmed
    ..Here we investigated the role of tetraspanin CD9 in hepatic granuloma formation...
  44. Unternaehrer J, Chow A, Pypaert M, Inaba K, Mellman I. The tetraspanin CD9 mediates lateral association of MHC class II molecules on the dendritic cell surface. Proc Natl Acad Sci U S A. 2007;104:234-9 pubmed
    ..Instead, it reflected the selective expression of the tetraspanin CD9 at the DC surface. I-A and I-E molecules coprecipitated with each other and with CD9...
  45. Rocha Perugini V, Martinez del Hoyo G, Gonzalez Granado J, Ramírez Huesca M, Zorita V, Rubinstein E, et al. CD9 Regulates Major Histocompatibility Complex Class II Trafficking in Monocyte-Derived Dendritic Cells. Mol Cell Biol. 2017;37: pubmed publisher
    ..However, the role of tetraspanin CD9 in these processes remains largely undefined...
  46. Kanatsu Shinohara M, Takashima S, Ishii K, Shinohara T. Dynamic changes in EPCAM expression during spermatogonial stem cell differentiation in the mouse testis. PLoS ONE. 2011;6:e23663 pubmed publisher
    ..To establish a system for SSC purification, we analyzed the expression of SSC markers CD9 and epithelial cell adhesion molecule (EPCAM), both of which are also expressed on embryonic stem (ES) cells...
  47. Ishibashi T, Ding L, Ikenaka K, Inoue Y, Miyado K, Mekada E, et al. Tetraspanin protein CD9 is a novel paranodal component regulating paranodal junctional formation. J Neurosci. 2004;24:96-102 pubmed
    ..Here we show that CD9, a member of the tetraspanin family, is present at the paranode...
  48. Cevik S, Keskin N, Belkaya S, Ozlu M, Deniz E, Tazebay U, et al. CD81 interacts with the T cell receptor to suppress signaling. PLoS ONE. 2012;7:e50396 pubmed publisher
    ..CD81 dependent alterations in thymocyte signaling are evident in increased CD5 expression on CD81 deficient double positive (DP) thymocytes. We conclude that CD81 interacts with the T cell receptor to suppress signaling. ..
  49. Stipp C, Kolesnikova T, Hemler M. EWI-2 is a major CD9 and CD81 partner and member of a novel Ig protein subfamily. J Biol Chem. 2001;276:40545-54 pubmed
    ..EWI-2 associated specifically with CD9 and CD81 but not with other tetraspanins or with integrins...
  50. Huang W, Febbraio M, Silverstein R. CD9 tetraspanin interacts with CD36 on the surface of macrophages: a possible regulatory influence on uptake of oxidized low density lipoprotein. PLoS ONE. 2011;6:e29092 pubmed publisher
    ..Mass spectrometry analysis of anti-CD36 immuno-precipitates from macrophages identified the tetraspanin CD9 as a CD36 interacting protein...
  51. Inoue N, Satouh Y, Ikawa M, Okabe M, Yanagimachi R. Acrosome-reacted mouse spermatozoa recovered from the perivitelline space can fertilize other eggs. Proc Natl Acad Sci U S A. 2011;108:20008-11 pubmed publisher
    ..We found that acrosome-reacted spermatozoa collected from the perivitelline space of Cd9-null mice (whose egg plasma membranes are incapable of fusing with spermatozoa) were able to pass through both the ..
  52. Wen Y, Quintero R, Chen B, Shu Y, Polan M, Behr B. Expression of CD9 in frozen-thawed mouse oocytes: preliminary experience. Fertil Steril. 2007;88:526-9 pubmed
    b>CD9 mRNA and protein expression levels in mouse slow frozen-rapid thawed oocytes were compared with those in fresh oocytes by using comparative quantitative real time reverse transcription-PCR and semiquantitative Western blot, ..
  53. Rubinstein E, Billard M, Plaisance S, Prenant M, Boucheix C. Molecular cloning of the mouse equivalent of CD9 antigen. Thromb Res. 1993;71:377-83 pubmed
    The CD9 antigen was originally described as a 24 kDa molecule present on B lineage-derived acute lymphoblastic leukemia cells and developing B-lymphocytes...
  54. Benammar A, Ziyyat A, Lefèvre B, Wolf J. Tetraspanins and Mouse Oocyte Microvilli Related to Fertilizing Ability. Reprod Sci. 2017;24:1062-1069 pubmed publisher
    ..Since several oocyte tetraspanins are involved in the gamete interaction, Cd9 being congregated on the MII oocyte microvilli, we analyzed the effect of tetraspanin deletion on oocyte membrane ..
  55. Qi J, Wang J, Mandadi S, Tanaka K, Roufogalis B, Madigan M, et al. Human and mouse mast cells use the tetraspanin CD9 as an alternate interleukin-16 receptor. Blood. 2006;107:135-42 pubmed
    ..CD4, and that the IL-16-mediated chemotactic and Ca2+ mobilization responses of this cell can be blocked by anti-CD9 monoclonal antibodies (mAbs) but not by mAbs directed against CD4 or other tetraspanins...
  56. Heinz M, Huang C, Emery D, Giovino M, LeGuern A, Kurilla Mahon B, et al. Use of CD9 expression to enrich for porcine hematopoietic progenitors. Exp Hematol. 2002;30:809-15 pubmed
    ..4-6 monoclonal line, allowing around 10-fold negative enrichment of SP cells, recognized the product of the porcine CD9 gene...
  57. Cailleteau L, Estrach S, Thyss R, Boyer L, Doye A, Domange B, et al. alpha2beta1 integrin controls association of Rac with the membrane and triggers quiescence of endothelial cells. J Cell Sci. 2010;123:2491-501 pubmed publisher
    ..Adapting the 'split-ubiquitin' sensor to screen for membrane-proximal alpha2 integrin partners, we identified the CD9 tetraspanin and further establish its requirement for destabilization of focal adhesions, control of Rac ..
  58. Hamatani T, Carter M, Sharov A, Ko M. Dynamics of global gene expression changes during mouse preimplantation development. Dev Cell. 2004;6:117-31 pubmed
    ..The large number of genes identified as involved in each phase is a first step toward analysis of the complex gene regulatory networks. ..
  59. Earnest J, Hantak M, Li K, McCray P, Perlman S, Gallagher T. The tetraspanin CD9 facilitates MERS-coronavirus entry by scaffolding host cell receptors and proteases. PLoS Pathog. 2017;13:e1006546 pubmed publisher
    ..Using knockout cell lines, we found that the tetraspanin CD9, but not the tetraspanin CD81, formed cell-surface complexes of dipeptidyl peptidase 4 (DPP4), the MERS-CoV ..
  60. Tai Nagara I, Yoshikawa Y, Numata N, Ando T, Okabe K, Sugiura Y, et al. Placental labyrinth formation in mice requires endothelial FLRT2/UNC5B signaling. Development. 2017;144:2392-2401 pubmed publisher
    ..Our results suggest that the proper organization of the placental labyrinth depends on coordinated inter-endothelial repulsion, which prevents uncontrolled layering of the endothelium. ..
  61. Ha C, Waterhouse R, Wessells J, Wu J, Dveksler G. Binding of pregnancy-specific glycoprotein 17 to CD9 on macrophages induces secretion of IL-10, IL-6, PGE2, and TGF-beta1. J Leukoc Biol. 2005;77:948-57 pubmed
    ..determine whether human and murine PSGs have similar functions and use the same receptor, we treated wild-type and CD9-deficient macrophages with murine PSG17N and human PSG1 and -11...
  62. Komorowski S, Baranowska B, Maleszewski M. CD9 protein appears on growing mouse oocytes at the time when they develop the ability to fuse with spermatozoa. Zygote. 2006;14:119-23 pubmed
    b>CD9 is a member of the tetraspanin superfamily proteins and is the only protein on the mouse oocyte which is known to be indispensable in sperm-egg fusion...
  63. Gupta S, Primakoff P, Myles D. Can the presence of wild-type oocytes during insemination rescue the fusion defect of CD9 null oocytes?. Mol Reprod Dev. 2009;76:602 pubmed publisher
  64. Wright M, Geary S, Fitter S, Moseley G, Lau L, Sheng K, et al. Characterization of mice lacking the tetraspanin superfamily member CD151. Mol Cell Biol. 2004;24:5978-88 pubmed
    ..CD151-null keratinocytes migrate poorly in skin explant cultures. Finally, CD151-null T lymphocytes are hyperproliferative in response to in vitro mitogenic stimulation. ..
  65. Juuri E, Saito K, Ahtiainen L, Seidel K, Tummers M, Hochedlinger K, et al. Sox2+ stem cells contribute to all epithelial lineages of the tooth via Sfrp5+ progenitors. Dev Cell. 2012;23:317-28 pubmed publisher
    ..The identification of Sox2 as a marker for the dental epithelial stem cells will facilitate further studies on their lineage segregation and differentiation during tooth renewal. ..
  66. Rubinstein E, Ziyyat A, Prenant M, Wrobel E, Wolf J, Levy S, et al. Reduced fertility of female mice lacking CD81. Dev Biol. 2006;290:351-8 pubmed
    In somatic cells, the tetraspanins CD81 and CD9 associate with each other, with additional tetraspanins and with non-tetraspanin molecules to form proteolipidic complexes...
  67. Schaeffer M, Han S, Chtanova T, van Dooren G, Herzmark P, Chen Y, et al. Dynamic imaging of T cell-parasite interactions in the brains of mice chronically infected with Toxoplasma gondii. J Immunol. 2009;182:6379-93 pubmed publisher
    ..Our data represent the first direct observation of the dynamics of T cell-parasite interactions within living tissue and provide a new perspective for understanding immune responses to persistent pathogens in the brain. ..
  68. Singh A, Lester C, Drapp R, Hu D, Glimcher L, Jones D. Tetraspanin CD9 and ectonucleotidase CD73 identify an osteochondroprogenitor population with elevated osteogenic properties. Development. 2015;142:438-43 pubmed publisher
    ..We show that the presence of tetraspanin CD9 enriches for osteochondroprogenitors within CD105(+) mesenchymal cells and that these cells readily form bone upon ..
  69. Zhang J, Dong J, Gu H, Yu S, Zhang X, Gou Y, et al. CD9 is critical for cutaneous wound healing through JNK signaling. J Invest Dermatol. 2012;132:226-36 pubmed publisher
    Cutaneous injury triggers a cascade of signaling events essential for wound re-epithelialization. CD9, a cell-surface protein, has been implicated in a number of cellular processes by coupling to intracellular signaling; however, its ..
  70. Jégou A, Ziyyat A, Barraud Lange V, Perez E, Wolf J, Pincet F, et al. CD9 tetraspanin generates fusion competent sites on the egg membrane for mammalian fertilization. Proc Natl Acad Sci U S A. 2011;108:10946-51 pubmed publisher
    b>CD9 tetraspanin is the only egg membrane protein known to be essential for fertilization...