Gene Symbol: CD8
Description: CD8 antigen, alpha chain
Alias: BB154331, Ly-2, Ly-35, Ly-B, Lyt-2, T-cell surface glycoprotein CD8 alpha chain, Lyt-2.1 lymphocyte differentiation antigen (AA at 100), T-cell surface glycoprotein Lyt-2
Species: mouse
Products:     CD8

Top Publications

  1. Dudziak D, Kamphorst A, Heidkamp G, Buchholz V, Trumpfheller C, Yamazaki S, et al. Differential antigen processing by dendritic cell subsets in vivo. Science. 2007;315:107-11 pubmed
    ..Unlike CD8+ DCs that express the cell surface protein CD205, CD8- DCs, which are positive for the 33D1 antigen, are ..
  2. Tanchot C, Lemonnier F, Perarnau B, Freitas A, Rocha B. Differential requirements for survival and proliferation of CD8 naïve or memory T cells. Science. 1997;276:2057-62 pubmed
    The requisite molecular interactions for CD8 T cell memory were determined by comparison of monoclonal naïve and memory CD8(+) T cells bearing the T cell receptor (TCR) for the HY antigen...
  3. Garefalaki A, Coles M, Hirschberg S, Mavria G, Norton T, Hostert A, et al. Variegated expression of CD8 alpha resulting from in situ deletion of regulatory sequences. Immunity. 2002;16:635-47 pubmed
    The developmental and subset-specific expression of the CD8 genes is under the control of a complex array of regulatory elements distributed along the locus and characterized by DNaseI hypersensitivity...
  4. Wang L, Wildt K, Zhu J, Zhang X, Feigenbaum L, Tessarollo L, et al. Distinct functions for the transcription factors GATA-3 and ThPOK during intrathymic differentiation of CD4(+) T cells. Nat Immunol. 2008;9:1122-30 pubmed publisher
    ..contexts permitted the 'redirection' of major histocompatibility complex class II-restricted thymocytes into the CD8(+) lineage...
  5. Kienzle N, Olver S, Buttigieg K, Groves P, Janas M, Baz A, et al. Progressive differentiation and commitment of CD8+ T cells to a poorly cytolytic CD8low phenotype in the presence of IL-4. J Immunol. 2005;174:2021-9 pubmed
    Exposure to IL-4 during activation of naive murine CD8+ T cells leads to generation of IL-4-producing effector cells with reduced surface CD8, low perforin, granzyme B and granzyme C mRNA, and poor cytolytic function...
  6. He X, He X, Dave V, Zhang Y, Hua X, Nicolas E, et al. The zinc finger transcription factor Th-POK regulates CD4 versus CD8 T-cell lineage commitment. Nature. 2005;433:826-33 pubmed
    Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, ..
  7. Zamoyska R, Vollmer A, Sizer K, Liaw C, Parnes J. Two Lyt-2 polypeptides arise from a single gene by alternative splicing patterns of mRNA. Cell. 1985;43:153-63 pubmed
    ..The nucleotide sequence of cDNA clones encoding each of these polypeptide chains has been determined and shows the difference between the two Lyt-2 polypeptide chains to be in the lengths of their cytoplasmic tails. ..
  8. Olver S, Apte S, Baz A, Kelso A, Kienzle N. Interleukin-4-induced loss of CD8 expression and cytolytic function in effector CD8 T cells persists long term in vivo. Immunology. 2013;139:187-96 pubmed publisher
    Activation of naive CD8(+) T cells in the presence of interleukin-4 modulates their CD8 co-receptor expression and functional differentiation, resulting in the generation of CD8(low) cells that produce type 2 cytokines and display poor ..
  9. Maile R, Siler C, Kerry S, Midkiff K, Collins E, Frelinger J. Peripheral "CD8 tuning" dynamically modulates the size and responsiveness of an antigen-specific T cell pool in vivo. J Immunol. 2005;174:619-27 pubmed
    In this study, we suggest that CD8 levels on T cells are not static, but can change and, as a result, modulate CD8(+) T cell responses...

More Information


  1. Andrews N, Pack C, Lukacher A. Generation of antiviral major histocompatibility complex class I-restricted T cells in the absence of CD8 coreceptors. J Virol. 2008;82:4697-705 pubmed publisher
    The CD8 coreceptor is important for positive selection of major histocompatibility complex I (MHC-I)-restricted thymocytes and in the generation of pathogen-specific T cells...
  2. Bosselut R, Kubo S, Guinter T, Kopacz J, Altman J, Feigenbaum L, et al. Role of CD8beta domains in CD8 coreceptor function: importance for MHC I binding, signaling, and positive selection of CD8+ T cells in the thymus. Immunity. 2000;12:409-18 pubmed
    The contribution of the CD8beta subunit to CD8 coreceptor function is poorly understood...
  3. Oakley M, McCutchan T, Anantharaman V, Ward J, Faucette L, Erexson C, et al. Host biomarkers and biological pathways that are associated with the expression of experimental cerebral malaria in mice. Infect Immun. 2008;76:4518-29 pubmed publisher
    ..with C57BL/6 mice, which have an ECM-susceptible phenotype, and with mice that have ECM-resistant phenotypes: CD8 knockout and perforin knockout mice on the C57BL/6 background and BALB/c mice...
  4. Borenstein S, Graham J, Zhang X, Chamberlain J. CD8+ T cells are necessary for recognition of allelic, but not locus-mismatched or xeno-, HLA class I transplantation antigens. J Immunol. 2000;165:2341-53 pubmed
    ..HLA allele) transplantation Ags revealed the following: 1) Although HLAhyb molecules induced stronger xeno-CD8+ T cell responses in vitro, additional effector mechanisms must be active in vivo because HLAnat skin grafts were ..
  5. Ellmeier W, Sunshine M, Losos K, Littman D. Multiple developmental stage-specific enhancers regulate CD8 expression in developing thymocytes and in thymus-independent T cells. Immunity. 1998;9:485-96 pubmed
    We and others have recently identified a CD8 locus enhancer (E8) that directs expression in mature CD8 single-positive thymocytes and peripheral CD8+ T cells and in extrathymically derived intestinal intraepithelial lymphocytes (IEL)...
  6. Kern P, Teng M, Smolyar A, Liu J, Liu J, Hussey R, et al. Structural basis of CD8 coreceptor function revealed by crystallographic analysis of a murine CD8alphaalpha ectodomain fragment in complex with H-2Kb. Immunity. 1998;9:519-30 pubmed
    ..In both species, coreceptor function apparently involves the participation of CD8 dimer in a bidentate attachment to an MHC class I molecule in conjunction with a T cell receptor without ..
  7. Hostert A, Garefalaki A, Mavria G, Tolaini M, Roderick K, Norton T, et al. Hierarchical interactions of control elements determine CD8alpha gene expression in subsets of thymocytes and peripheral T cells. Immunity. 1998;9:497-508 pubmed
    CD4 and CD8 are crucial for the development and function of T cells. An intergenic deoxyribonuclease I hypersensitive site region (cluster CIII) directs expression in mature CD8 T cells only...
  8. Bosselut R, Feigenbaum L, Sharrow S, Singer A. Strength of signaling by CD4 and CD8 coreceptor tails determines the number but not the lineage direction of positively selected thymocytes. Immunity. 2001;14:483-94 pubmed
    The present study has assessed the impact of the intracellular domains of CD4 and CD8 on positive selection and lineage direction of MHC class I-restricted thymocytes...
  9. Kennedy M, Glaccum M, Brown S, Butz E, Viney J, Embers M, et al. Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice. J Exp Med. 2000;191:771-80 pubmed
    ..mice displayed marked reductions in numbers of thymic and peripheral natural killer (NK) T cells, memory phenotype CD8(+) T cells, and distinct subpopulations of intestinal intraepithelial lymphocytes (IELs)...
  10. Mott K, Underhill D, Wechsler S, Ghiasi H. Lymphoid-related CD11c+ CD8alpha+ dendritic cells are involved in enhancing herpes simplex virus type 1 latency. J Virol. 2008;82:9870-9 pubmed publisher
    ..Latency was also significantly reduced in Flt3L(-/-) and CD8(-/-) mice. Interestingly, immunization of Flt3L(-/-) but not CD8(-/-) mice with Flt3L DNA increased latency...
  11. Akiyama T, Shimo Y, Yanai H, Qin J, Ohshima D, Maruyama Y, et al. The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance. Immunity. 2008;29:423-37 pubmed publisher
    ..These results show that developmental-stage-dependent cooperation between RANK and CD40 promotes mTEC development, thereby establishing self-tolerance. ..
  12. Miyahara N, Swanson B, Takeda K, Taube C, Miyahara S, Kodama T, et al. Effector CD8+ T cells mediate inflammation and airway hyper-responsiveness. Nat Med. 2004;10:865-9 pubmed
    ..Using a mouse model of allergen-induced AHR, we previously demonstrated that CD8-deficient mice develop significantly lower AHR, eosinophilic inflammation and interleukin (IL)-13 levels in ..
  13. Fung Leung W, Schilham M, Rahemtulla A, Kundig T, Vollenweider M, Potter J, et al. CD8 is needed for development of cytotoxic T cells but not helper T cells. Cell. 1991;65:443-9 pubmed
    A mutant mouse strain without CD8 (Lyt-2 and Lyt-3) expression on the cell surface has been generated by disrupting the Lyt-2 gene using embryonic stem cell technology...
  14. Gorman S, Sun Y, Zamoyska R, Parnes J. Molecular linkage of the Ly-3 and Ly-2 genes. Requirement of Ly-2 for Ly-3 surface expression. J Immunol. 1988;140:3646-53 pubmed
    ..L cells results in cell surface expression of Ly-3 protein only in the presence of Ly-2 (or its human homolog, CD8), although Ly-2 surface expression is not similarly dependent on Ly-3...
  15. Park J, Adoro S, Lucas P, Sarafova S, Alag A, Doan L, et al. 'Coreceptor tuning': cytokine signals transcriptionally tailor CD8 coreceptor expression to the self-specificity of the TCR. Nat Immunol. 2007;8:1049-59 pubmed
    ..Here we identify a homeostatic mechanism that transcriptionally tailors CD8 coreceptor expression in individual CD8+ T cells to the self-specificity of their clonotypic T cell receptor (TCR)...
  16. Harker N, Garefalaki A, Menzel U, Ktistaki E, Naito T, Georgopoulos K, et al. Pre-TCR signaling and CD8 gene bivalent chromatin resolution during thymocyte development. J Immunol. 2011;186:6368-77 pubmed publisher
    The CD8 gene is silent in CD4(-)CD8(-) double-negative thymocytes, expressed in CD4(+)CD8(+) double-positive cells, and silenced in cells committing to the CD4(+) single-positive (SP) lineage, remaining active in the CD8(+) SP lineage...
  17. Miyahara N, Takeda K, Miyahara S, Taube C, Joetham A, Koya T, et al. Leukotriene B4 receptor-1 is essential for allergen-mediated recruitment of CD8+ T cells and airway hyperresponsiveness. J Immunol. 2005;174:4979-84 pubmed
    Recent studies in both human and rodents have indicated that in addition to CD4+ T cells, CD8+ T cells play an important role in allergic inflammation...
  18. Miyahara N, Takeda K, Kodama T, Joetham A, Taube C, Park J, et al. Contribution of antigen-primed CD8+ T cells to the development of airway hyperresponsiveness and inflammation is associated with IL-13. J Immunol. 2004;172:2549-58 pubmed
    ..Th2/CD4 T cells, which secrete IL-4, IL-5, and IL-13, in allergic disease is well established; however, the role of CD8(+) T cells (allergen-induced airway hyperresponsiveness (AHR) and inflammation) is less clear...
  19. Bilic I, Koesters C, Unger B, Sekimata M, Hertweck A, Maschek R, et al. Negative regulation of CD8 expression via Cd8 enhancer-mediated recruitment of the zinc finger protein MAZR. Nat Immunol. 2006;7:392-400 pubmed
    Coreceptor expression is tightly regulated during thymocyte development. Deletion of specific Cd8 enhancers leads to variegated expression of CD8alphabeta heterodimers in double-positive thymocytes...
  20. Leishman A, Naidenko O, Attinger A, Koning F, Lena C, Xiong Y, et al. T cell responses modulated through interaction between CD8alphaalpha and the nonclassical MHC class I molecule, TL. Science. 2001;294:1936-9 pubmed
    ..These findings define a novel mechanism of lymphocyte regulation through CD8alphaalpha and MHC class I. ..
  21. Hostert A, Tolaini M, Festenstein R, McNeill L, Malissen B, Williams O, et al. A CD8 genomic fragment that directs subset-specific expression of CD8 in transgenic mice. J Immunol. 1997;158:4270-81 pubmed
    Helper and cytotoxic T cell subsets require the expression of different coreceptors (CD4 and CD8, respectively) for their development and function...
  22. Sakaguchi S, Hombauer M, Bilic I, Naoe Y, Schebesta A, Taniuchi I, et al. The zinc-finger protein MAZR is part of the transcription factor network that controls the CD4 versus CD8 lineage fate of double-positive thymocytes. Nat Immunol. 2010;11:442-8 pubmed publisher
    The CD4 versus CD8 lineage specification of thymocytes is linked to coreceptor expression. The transcription factor MAZR has been identified as an important regulator of Cd8 expression...
  23. Feik N, Bilic I, Tinhofer J, Unger B, Littman D, Ellmeier W. Functional and molecular analysis of the double-positive stage-specific CD8 enhancer E8III during thymocyte development. J Immunol. 2005;174:1513-24 pubmed
    Several developmental stage-, subset-, and lineage-specific Cd8 cis-regulatory regions have been identified...
  24. Hassan H, Sakaguchi S, Tenno M, Kopf A, Boucheron N, Carpenter A, et al. Cd8 enhancer E8I and Runx factors regulate CD8? expression in activated CD8+ T cells. Proc Natl Acad Sci U S A. 2011;108:18330-5 pubmed publisher
    Cd8a and Cd8b1 coreceptor gene (Cd8) expression is tightly controlled during T-cell development by the activity of five Cd8 enhancers (E8(I)-E8(V))...
  25. Ellmeier W, Sunshine M, Maschek R, Littman D. Combined deletion of CD8 locus cis-regulatory elements affects initiation but not maintenance of CD8 expression. Immunity. 2002;16:623-34 pubmed
    Developmental stage-, subset-, and lineage-specific CD8 enhancers have been identified recently by transgenic reporter analyses...
  26. Gartlan K, Belz G, Tarrant J, Minigo G, Katsara M, Sheng K, et al. A complementary role for the tetraspanins CD37 and Tssc6 in cellular immunity. J Immunol. 2010;185:3158-66 pubmed publisher
    ..Therefore, in the absence of both CD37 and Tssc6, immune function is further altered when compared with CD37(-/-) or Tssc6(-/-) mice, demonstrating a complementary role for these two molecules in cellular immunity...
  27. Fung Leung W, Louie M, Limmer A, Ohashi P, Ngo K, Chen L, et al. The lack of CD8 alpha cytoplasmic domain resulted in a dramatic decrease in efficiency in thymic maturation but only a moderate reduction in cytotoxic function of CD8+ T lymphocytes. Eur J Immunol. 1993;23:2834-40 pubmed
    The glycoprotein CD8 is believed to play an important role in the maturation and function of MHC class I-restricted T lymphocytes...
  28. Chiang E, Stroynowski I. A nonclassical MHC class I molecule restricts CTL-mediated rejection of a syngeneic melanoma tumor. J Immunol. 2004;173:4394-401 pubmed
    ..immunity is lost or greatly diminished in mice deficient in CTL, including beta(2)-microglobulin knockout (KO), CD8 KO, and SCID mice...
  29. Dragovic S, Hill T, Christianson G, Kim S, Elliott T, Scott D, et al. Proteasomes, TAP, and endoplasmic reticulum-associated aminopeptidase associated with antigen processing control CD4+ Th cell responses by regulating indirect presentation of MHC class II-restricted cytoplasmic antigens. J Immunol. 2011;186:6683-92 pubmed publisher
    ..From these findings, a novel model emerged in which the cytosolic Ag-processing machinery regulates the quantity of cytoplasmic peptides available for presentation by class II molecules and, hence, modulates Th cell responses...
  30. Goldszmid R, Bafica A, Jankovic D, Feng C, Caspar P, Winkler Pickett R, et al. TAP-1 indirectly regulates CD4+ T cell priming in Toxoplasma gondii infection by controlling NK cell IFN-gamma production. J Exp Med. 2007;204:2591-602 pubmed
    To investigate if transporter associated with antigen processing (TAP)-1 is required for CD8(+) T cell-mediated control of Toxoplasma gondii in vivo, we compared the resistance of TAP-1(-/-), CD8(-/-), and wild-type (WT) mice to ..
  31. Di Piazza M, Nowell C, Koch U, Durham A, Radtke F. Loss of cutaneous TSLP-dependent immune responses skews the balance of inflammation from tumor protective to tumor promoting. Cancer Cell. 2012;22:479-93 pubmed publisher
    ..demonstrate that TSLP-mediated inflammation protects against cutaneous carcinogenesis by acting directly on CD4 and CD8 T cells...
  32. Van Kaer L, Rabacal W, Scott Algood H, Parekh V, Olivares Villagómez D. In vitro induction of regulatory CD4+CD8?+ T cells by TGF-?, IL-7 and IFN-?. PLoS ONE. 2013;8:e67821 pubmed publisher
    ..Mature CD4(+) T cells expressing CD8?? homodimers are primarily found in the intestinal mucosa of men and mice, and to a lesser extent in other tissues ..
  33. Fragoso R, Pyarajan S, Irie H, Burakoff S. A CD8/Lck transgene is able to drive thymocyte differentiation. J Immunol. 2006;177:6007-17 pubmed
    Efficient development of thymocytes requires participation of a CD8 or CD4 coreceptor in the TCR:MHC interaction. Both CD8 and CD4 coreceptor cytoplasmic domains associate with Lck...
  34. Boyd R, Goldrick M, Gottlieb P. Genetic polymorphism at the mouse immunoglobulin J kappa locus (Igk-J) as demonstrated by Southern hybridization and nucleotide sequence analysis. Immunogenetics. 1986;24:150-7 pubmed
    ..Two of these substitutions reflect true germ-line differences, raising the possibility that idiotype differences observed among strains could reflect J kappa as well as V kappa differences. ..
  35. Tang X, Maricic I, Kumar V. Anti-TCR antibody treatment activates a novel population of nonintestinal CD8 alpha alpha+ TCR alpha beta+ regulatory T cells and prevents experimental autoimmune encephalomyelitis. J Immunol. 2007;178:6043-50 pubmed
    ..These data suggest that activation of the CD8alphaalpha Tregs present in peripheral lymphoid organs other than the gut can be exploited for the control of T cell-mediated autoimmune diseases. ..
  36. Tamehiro N, Oda H, Shirai M, Suzuki H. Overexpression of RhoH Permits to Bypass the Pre-TCR Checkpoint. PLoS ONE. 2015;10:e0131047 pubmed publisher
    ..However, transgenic introduction of RhoH into Rag2 deficient mice resulted in the generation of CD4+ CD8+ (DP) thymocytes, indicating that overexpression of RhoH could bypass β-selection without TCRβ gene ..
  37. Chen S, Takeoka Y, Ansari A, Boyd R, Klinman D, Gershwin M. The natural history of disease expression in CD4 and CD8 gene-deleted New Zealand black (NZB) mice. J Immunol. 1996;157:2676-84 pubmed
    CD4 and CD8 gene-deleted New Zealand black (NZB) mice and, as controls, B6.CD4 -/-, B6...
  38. Boyse E, Miyazawa M, Aoki T, Old L. Ly-A and Ly-B: two systems of lymphocyte isoantigens in the mouse. Proc R Soc Lond B Biol Sci. 1968;170:175-93 pubmed
  39. D Hoostelaere L, Huppi K, Mock B, Mallett C, Potter M. The Ig kappa L chain allelic groups among the Ig kappa haplotypes and Ig kappa crossover populations suggest a gene order. J Immunol. 1988;141:652-61 pubmed
  40. Fung Leung W, Kundig T, Ngo K, Panakos J, de Sousa Hitzler J, Wang E, et al. Reduced thymic maturation but normal effector function of CD8+ T cells in CD8 beta gene-targeted mice. J Exp Med. 1994;180:959-67 pubmed
    b>CD8 is a cell surface glycoprotein on major histocompatibility complex class I-restricted T cells. Thymocytes and most peripheral T cells express CD8 as heterodimers of CD8 alpha and CD8 beta...
  41. Van Laethem F, Sarafova S, Park J, Tai X, Pobezinsky L, Guinter T, et al. Deletion of CD4 and CD8 coreceptors permits generation of alphabetaT cells that recognize antigens independently of the MHC. Immunity. 2007;27:735-50 pubmed
    ..that MHC specificity might be imposed on a broader alphabetaTCR repertoire during thymic selection by CD4 and CD8 coreceptors that bind and effectively sequester the tyrosine kinase Lck, thereby preventing T cell receptor (TCR) ..
  42. Giroux M, Yurchenko E, St Pierre J, Piccirillo C, Perreault C. T regulatory cells control numbers of NK cells and CD8alpha+ immature dendritic cells in the lymph node paracortex. J Immunol. 2007;179:4492-502 pubmed
  43. Takayanagi S, Hiroyama T, Yamazaki S, Nakajima T, Morita Y, Usui J, et al. Genetic marking of hematopoietic stem and endothelial cells: identification of the Tmtsp gene encoding a novel cell surface protein with the thrombospondin-1 domain. Blood. 2006;107:4317-25 pubmed
  44. French J, Roark C, Born W, O Brien R. {gamma}{delta} T cell homeostasis is established in competition with {alpha}{beta} T cells and NK cells. Proc Natl Acad Sci U S A. 2005;102:14741-6 pubmed
    ..Our results suggest that CD8(+) alphabeta T cells are the most potent inhibitors of gammadelta T cell homeostasis and exert their effect by ..
  45. Lesourne R, Uehara S, Lee J, Song K, Li L, Pinkhasov J, et al. Themis, a T cell-specific protein important for late thymocyte development. Nat Immunol. 2009;10:840-7 pubmed publisher
    ..thymocytes transition through a stage during which T cell antigen receptor (TCR) signaling controls CD4-versus-CD8 lineage 'choice' and subsequent maturation...
  46. McKee A, Pearce E. CD25+CD4+ cells contribute to Th2 polarization during helminth infection by suppressing Th1 response development. J Immunol. 2004;173:1224-31 pubmed
    ..The data suggest that natural Treg cells and, to a lesser extent, Th2 cells play roles in suppressing Th1 responses and ensuring Th2 polarization during schistosomiasis. ..
  47. Newell K, He G, Guo Z, Kim O, Szot G, Rulifson I, et al. Cutting edge: blockade of the CD28/B7 costimulatory pathway inhibits intestinal allograft rejection mediated by CD4+ but not CD8+ T cells. J Immunol. 1999;163:2358-62 pubmed
    ..of allografts transplanted into wild-type or CD4 knockout (KO) mice but did inhibit allograft rejection by CD8 KO recipients...
  48. Nakamura S, Dairiki K, Ikegami S, Kochiya M, Fujimori T, Tamaoki N, et al. Ly-36: a new mouse lymphocyte alloantigen defined by a Mus musculus molossinus-specific monoclonal antibody and controlled by a gene linked to Ly-2/3 region on chromosome 6. Immunogenetics. 1988;28:50-2 pubmed
  49. Lacorazza H, Nikolich Zugich J. Exclusion and inclusion of TCR alpha proteins during T cell development in TCR-transgenic and normal mice. J Immunol. 2004;173:5591-600 pubmed
    ..In searching for the mechanism(s) governing this selective TCRalpha down-regulation, we present evidence for the role of protein tyrosine kinase signaling and coreceptor involvement. This mechanism may be operating in normal thymocytes. ..
  50. Wilcox F, Roderick T. Location on chromosome 6 of the locus for a major liver protein (Lvp-1) of the house mouse. Genet Res. 1982;40:213-5 pubmed
  51. Dai Y, Marrero I, Gros P, Zaghouani H, Wicker L, Sercarz E. Slc11a1 enhances the autoimmune diabetogenic T-cell response by altering processing and presentation of pancreatic islet antigens. Diabetes. 2009;58:156-64 pubmed publisher
    ..Thus, non-MHC genes could affect the MHC-restricted T-cell response through altered antigen processing and presentation. ..
  52. Collins A, Hewitt S, Chaumeil J, Sellars M, Micsinai M, Allinne J, et al. RUNX transcription factor-mediated association of Cd4 and Cd8 enables coordinate gene regulation. Immunity. 2011;34:303-14 pubmed publisher
    T cell fate is associated with mutually exclusive expression of CD4 or CD8 in helper and cytotoxic T cells, respectively...
  53. del Rio M, Cote Sierra J, Rodriguez Barbosa J. Flt3L-mobilized dendritic cells bearing H2-Kbm1 apoptotic cells do not induce cross-tolerance to CD8+ T cells across a class I MHC mismatched barrier. Transpl Int. 2011;24:501-13 pubmed publisher
    Tolerization of allogeneic CD8(+) T cells is still a pending issue in the field of transplantation research to achieve long-term survival...
  54. Daniel D, Meyer Morse N, Bergsland E, Dehne K, Coussens L, Hanahan D. Immune enhancement of skin carcinogenesis by CD4+ T cells. J Exp Med. 2003;197:1017-28 pubmed
  55. Terszowski G, Müller S, Bleul C, Blum C, Schirmbeck R, Reimann J, et al. Evidence for a functional second thymus in mice. Science. 2006;312:284-7 pubmed
    ..The identification of a regular second thymus in the mouse may provide evolutionary links to thymus organogenesis in other vertebrates and suggests a need to reconsider the effect of thoracic thymectomy on de novo T cell production. ..
  56. Ngai P, McCormick S, Small C, Zhang X, Zganiacz A, Aoki N, et al. Gamma interferon responses of CD4 and CD8 T-cell subsets are quantitatively different and independent of each other during pulmonary Mycobacterium bovis BCG infection. Infect Immun. 2007;75:2244-52 pubmed
    ..It has been believed that both CD4 and CD8 T cells are the primary sources of IFN-gamma...
  57. Van Laethem F, Tikhonova A, Pobezinsky L, Tai X, Kimura M, Le Saout C, et al. Lck availability during thymic selection determines the recognition specificity of the T cell repertoire. Cell. 2013;154:1326-41 pubmed publisher
  58. Sun K, Metzger D. Inhibition of pulmonary antibacterial defense by interferon-gamma during recovery from influenza infection. Nat Med. 2008;14:558-64 pubmed publisher
    ..Thus, IFN-gamma, although probably facilitating induction of specific anti-influenza adaptive immunity, suppresses innate protection against extracellular bacterial pathogens in the lung. ..
  59. Venet F, Chung C, Huang X, Lomas Neira J, Chen Y, Ayala A. Lymphocytes in the development of lung inflammation: a role for regulatory CD4+ T cells in indirect pulmonary lung injury. J Immunol. 2009;183:3472-80 pubmed publisher
  60. Sardinha L, Elias R, Mosca T, Bastos K, Marinho C, D Império Lima M, et al. Contribution of NK, NK T, gamma delta T, and alpha beta T cells to the gamma interferon response required for liver protection against Trypanosoma cruzi. Infect Immun. 2006;74:2031-42 pubmed
    ..The contribution of different cell populations was suggested by data showing that CD4- and CD8-deficient mice were able to restrain liver parasite growth...
  61. Tada Y, Ho A, Koh D, Mak T. Collagen-induced arthritis in CD4- or CD8-deficient mice: CD8+ T cells play a role in initiation and regulate recovery phase of collagen-induced arthritis. J Immunol. 1996;156:4520-6 pubmed
    ..We studied CIA in CD4- or CD8-deficient DBA/1 mice to further define the roles of CD4+ and CD8+ T cells in the disease...
  62. Zhou H, Yan H, Cannon J, Springer L, Green J, Pham C. CD43-mediated IFN-? production by CD8+ T cells promotes abdominal aortic aneurysm in mice. J Immunol. 2013;190:5078-85 pubmed publisher
    ..Moreover, we found that IFN-?-producing CD8(+) T cells, but not CD4(+) T cells, promote the development of aneurysm by enhancing cellular apoptosis and matrix ..
  63. Bertrand F, Rochotte J, Colacios C, Montfort A, Tilkin Mariamé A, Touriol C, et al. Blocking Tumor Necrosis Factor α Enhances CD8 T-cell-Dependent Immunity in Experimental Melanoma. Cancer Res. 2015;75:2619-28 pubmed publisher
    ..was dramatically impaired in TNF-deficient mice, and this was associated with enhanced tumor-infiltrating CD8(+) T lymphocytes. Immunodepletion of CD8 T cells fully restored melanoma growth in TNF(-/-) mice...
  64. Burrer R, Buchmeier M, Wolfe T, Ting J, Feuer R, Iglesias A, et al. Exacerbated pathology of viral encephalitis in mice with central nervous system-specific autoantibodies. Am J Pathol. 2007;170:557-66 pubmed
    ..Our study illustrates the possibility that infections can lead to much more profound immunopathology in the presence of an otherwise latent autoimmune condition...
  65. Bruce D, Cantorna M. Intrinsic requirement for the vitamin D receptor in the development of CD8??-expressing T cells. J Immunol. 2011;186:2819-25 pubmed publisher
    ..The intraepithelial lymphocytes of the small intestine contain large numbers of CD8??(+) T cells that have been shown to suppress the immune response to Ags found there...
  66. Ehinger M, Vestberg M, Johansson A, Johannesson M, Svensson A, Holmdahl R. Influence of CD4 or CD8 deficiency on collagen-induced arthritis. Immunology. 2001;103:291-300 pubmed
    ..for rheumatoid arthritis is not clarified, and different results have been reported concerning the role of CD4 and CD8 T cells. To address this issue, we have investigated B10.Q mice deficient for CD4 or CD8...
  67. Chandele A, Kaech S. Cutting edge: memory CD8 T cell maturation occurs independently of CD8alphaalpha. J Immunol. 2005;175:5619-23 pubmed
    As memory CD8 T cells form during acute viral infection, several changes in gene expression and function occur, but little is known about the control of this process...
  68. Kang Y, Wang X, Lin S, Hsu Y, Chang H. An active CD8alpha/pMHCI interaction is required for CD8 single positive thymocyte differentiation. Eur J Immunol. 2010;40:836-48 pubmed publisher major histocompatibility complex class I molecules (MHCI) by TCR is critical for initiating the responses of CD8(+) T cells that ultimately lead to elimination of virus-infected cells...
  69. Belz G, Bedoui S, Kupresanin F, Carbone F, Heath W. Minimal activation of memory CD8+ T cell by tissue-derived dendritic cells favors the stimulation of naive CD8+ T cells. Nat Immunol. 2007;8:1060-6 pubmed
    Of the many dendritic cell (DC) subsets, DCs expressing the monomorphic coreceptor CD8 alpha-chain (CD8alpha) are localized permanently in lymphoid organs, whereas 'tissue-derived DCs' remain in nonlymphoid tissues until they 'capture' ..
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