Gene Symbol: Cd69
Description: CD69 antigen
Alias: 5830438K24Rik, AI452015, AIM, VEA, early activation antigen CD69, Very Early Activation Antigen
Species: mouse
Products:     Cd69

Top Publications

  1. Ng L, Sutherland A, Newton R, Qian F, Cachero T, Scott M, et al. B cell-activating factor belonging to the TNF family (BAFF)-R is the principal BAFF receptor facilitating BAFF costimulation of circulating T and B cells. J Immunol. 2004;173:807-17 pubmed
    ..Thus, BAFF-R is important not only for splenic B cell maturation, but is the major mediator of BAFF-dependent costimulatory responses in peripheral B and T cells. ..
  2. Cambiaggi C, Scupoli M, Cestari T, Gerosa F, Carra G, Tridente G, et al. Constitutive expression of CD69 in interspecies T-cell hybrids and locus assignment to human chromosome 12. Immunogenetics. 1992;36:117-20 pubmed
    ..Phenotypic analysis of two hybrids and their clones demonstrated coexpression of CD4 and CD69 antigens in the same cells...
  3. Esplugues E, Sancho D, Vega Ramos J, Martinez C, Syrbe U, Hamann A, et al. Enhanced antitumor immunity in mice deficient in CD69. J Exp Med. 2003;197:1093-106 pubmed
    We investigated the in vivo role of CD69 by analyzing the susceptibility of CD69-/- mice to tumors...
  4. Abe J, Ueha S, Suzuki J, Tokano Y, Matsushima K, Ishikawa S. Increased Foxp3(+) CD4(+) regulatory T cells with intact suppressive activity but altered cellular localization in murine lupus. Am J Pathol. 2008;173:1682-92 pubmed publisher
    ..Taken together, we conclude that T(reg) cells in BWF1 mice are not predisposed to functional incompetence but rather are present in a highly activated state. ..
  5. Vega Ramos J, Alari Pahissa E, Valle J, Carrasco Marin E, Esplugues E, Borras M, et al. CD69 limits early inflammatory diseases associated with immune response to Listeria monocytogenes infection. Immunol Cell Biol. 2010;88:707-15 pubmed publisher
    ..b>CD69 is expressed in all leukocytes during activation after infection with a wide range of microbial pathogens...
  6. Ziegler S, Levin S, Johnson L, Copeland N, Gilbert D, Jenkins N, et al. The mouse CD69 gene. Structure, expression, and mapping to the NK gene complex. J Immunol. 1994;152:1228-36 pubmed
    b>CD69 is a rapidly induced T cell activation Ag that is also expressed in an inducible fashion on cells of most, if not all, hematopoietic lineages...
  7. Sancho D, Gomez M, Martinez del Hoyo G, Lamana A, Esplugues E, Lauzurica P, et al. CD69 targeting differentially affects the course of collagen-induced arthritis. J Leukoc Biol. 2006;80:1233-41 pubmed
    b>CD69 expression is induced following activation of leukocytes at inflammatory sites and plays a negative regulatory role in the development of collagen-induced arthritis (CIA)...
  8. Llera A, Viedma F, Sanchez Madrid F, Tormo J. Crystal structure of the C-type lectin-like domain from the human hematopoietic cell receptor CD69. J Biol Chem. 2001;276:7312-9 pubmed
    b>CD69, one of the earliest specific antigens acquired during lymphoid activation, acts as a signal-transducing receptor involved in cellular activation events, including proliferation and induction of specific genes...
  9. Lauzurica P, Sancho D, Torres M, Albella B, Marazuela M, Merino T, et al. Phenotypic and functional characteristics of hematopoietic cell lineages in CD69-deficient mice. Blood. 2000;95:2312-20 pubmed
    AIM/CD69 is the earliest leukocyte activation antigen and is expressed mainly by activated T, B, and natural killer (NK) cells...

More Information


  1. Sancho D, Gomez M, Viedma F, Esplugues E, Gordón Alonso M, García López M, et al. CD69 downregulates autoimmune reactivity through active transforming growth factor-beta production in collagen-induced arthritis. J Clin Invest. 2003;112:872-82 pubmed
    b>CD69 is induced after activation of leukocytes at inflammatory sites, but its physiological role during inflammation remains unknown...
  2. Miki Hosokawa T, Hasegawa A, Iwamura C, Shinoda K, Tofukuji S, Watanabe Y, et al. CD69 controls the pathogenesis of allergic airway inflammation. J Immunol. 2009;183:8203-15 pubmed publisher
    Airway inflammation and airway hyperresponsiveness are central issues in the pathogenesis of asthma. CD69 is a membrane molecule transiently expressed on activated lymphocytes, and its selective expression in inflammatory infiltrates ..
  3. Martin P, Gomez M, Lamana A, Matesanz Marín A, Cortes J, Ramírez Huesca M, et al. The leukocyte activation antigen CD69 limits allergic asthma and skin contact hypersensitivity. J Allergy Clin Immunol. 2010;126:355-65, 365.e1-3 pubmed publisher
    ..We have investigated the role of the leukocyte activation antigen CD69 in the regulation of two allergic diseases, asthma and contact dermatitis...
  4. Shiow L, Rosen D, Brdicková N, Xu Y, An J, Lanier L, et al. CD69 acts downstream of interferon-alpha/beta to inhibit S1P1 and lymphocyte egress from lymphoid organs. Nature. 2006;440:540-4 pubmed
    ..The transmembrane C-type lectin CD69 was rapidly induced and CD69-/- cells were poorly retained in lymphoid tissues after treatment with poly(I:C) or ..
  5. Lamana A, Martin P, de la Fuente H, Martínez Muñoz L, Cruz Adalia A, Ramírez Huesca M, et al. CD69 modulates sphingosine-1-phosphate-induced migration of skin dendritic cells. J Invest Dermatol. 2011;131:1503-12 pubmed publisher
    In this study, we have investigated the role of CD69, an early inducible leukocyte activation receptor, in murine dendritic cell (DC) differentiation, maturation, and migration...
  6. Murata K, Inami M, Hasegawa A, Kubo S, Kimura M, Yamashita M, et al. CD69-null mice protected from arthritis induced with anti-type II collagen antibodies. Int Immunol. 2003;15:987-92 pubmed
    b>CD69, known as an early activation marker antigen on T and B cells, is also expressed on platelets and activated neutrophils, suggesting certain roles in inflammatory diseases...
  7. Radulovic K, Manta C, Rossini V, Holzmann K, Kestler H, Wegenka U, et al. CD69 regulates type I IFN-induced tolerogenic signals to mucosal CD4 T cells that attenuate their colitogenic potential. J Immunol. 2012;188:2001-13 pubmed publisher
    b>CD69 is highly expressed by lymphocytes at mucosal surfaces. We aimed to investigate the role of CD69 in mucosal immune responses...
  8. Brown M, Fulmek S, Matsumoto K, Cho R, Lyons P, Levy E, et al. A 2-Mb YAC contig and physical map of the natural killer gene complex on mouse chromosome 6. Genomics. 1997;42:16-25 pubmed
    ..Herein we show that Nkrp1 genes are clustered in a region flanked by A2m and Cd69 genes and that most Ly49 genes are clustered in a distal region -1 Mb distant...
  9. Shinoda K, Tokoyoda K, Hanazawa A, Hayashizaki K, Zehentmeier S, Hosokawa H, et al. Type II membrane protein CD69 regulates the formation of resting T-helper memory. Proc Natl Acad Sci U S A. 2012;109:7409-14 pubmed publisher
    ..Here we show that CD69-deficient effector CD4 T lymphocytes fail to relocate into and persist in the BM and therefore to differentiate ..
  10. Testi R, D Ambrosio D, De Maria R, Santoni A. The CD69 receptor: a multipurpose cell-surface trigger for hematopoietic cells. Immunol Today. 1994;15:479-83 pubmed
    b>CD69 was initially described as being restricted to recently activated lymphoid cells, but is now known to be expressed on the surface of all hematopoietically derived leukocytes...
  11. Lopez Cabrera M, Santis A, Fernández Ruiz E, Blacher R, Esch F, Sánchez Mateos P, et al. Molecular cloning, expression, and chromosomal localization of the human earliest lymphocyte activation antigen AIM/CD69, a new member of the C-type animal lectin superfamily of signal-transmitting receptors. J Exp Med. 1993;178:537-47 pubmed
    The activation of T lymphocytes, both in vivo and in vitro, induces the expression of CD69. This molecule, which appears to be the earliest inducible cell surface glycoprotein acquired during lymphoid activation, is involved in lymphocyte ..
  12. Ziegler S, Ramsdell F, Hjerrild K, Armitage R, Grabstein K, Hennen K, et al. Molecular characterization of the early activation antigen CD69: a type II membrane glycoprotein related to a family of natural killer cell activation antigens. Eur J Immunol. 1993;23:1643-8 pubmed
    b>CD69 is a disulfide-linked homo-dimer expressed on the surface of activated T cells, B cells, natural killer cells, neutrophils and platelets...
  13. Han Y, Guo Q, Zhang M, Chen Z, Cao X. CD69+ CD4+ CD25- T cells, a new subset of regulatory T cells, suppress T cell proliferation through membrane-bound TGF-beta 1. J Immunol. 2009;182:111-20 pubmed
    ..b>CD69 is generally regarded as one of the activating markers; however, recent studies show that CD69 may exert regulatory ..
  14. Feng C, Woodside K, Vance B, El Khoury D, Canelles M, Lee J, et al. A potential role for CD69 in thymocyte emigration. Int Immunol. 2002;14:535-44 pubmed
    The early activation marker, CD69, is transiently expressed on activated mature T cells and on thymocytes that are undergoing positive or negative selection in the thymus...
  15. Bankovich A, Shiow L, Cyster J. CD69 suppresses sphingosine 1-phosophate receptor-1 (S1P1) function through interaction with membrane helix 4. J Biol Chem. 2010;285:22328-37 pubmed publisher
    ..The activation antigen CD69 associates with and inhibits the function of S1P(1), inhibiting egress...
  16. Ho E, Heusel J, Brown M, Matsumoto K, Scalzo A, Yokoyama W. Murine Nkg2d and Cd94 are clustered within the natural killer complex and are expressed independently in natural killer cells. Proc Natl Acad Sci U S A. 1998;95:6320-5 pubmed
    ..Last, we have finely mapped the physical location of the Cd94 (centromeric) and Nkg2d (telomeric) genes between Cd69 and the Ly49 cluster in the NK complex...
  17. Marzio R, Jirillo E, Ransijn A, Mauel J, Corradin S. Expression and function of the early activation antigen CD69 in murine macrophages. J Leukoc Biol. 1997;62:349-55 pubmed
    b>CD69, a member of the natural killer cell gene complex family of signal transducing receptors, represents one of the earliest activation antigens in human and murine lymphocytes...
  18. Martin P, Gomez M, Lamana A, Cruz Adalia A, Ramírez Huesca M, Ursa M, et al. CD69 association with Jak3/Stat5 proteins regulates Th17 cell differentiation. Mol Cell Biol. 2010;30:4877-89 pubmed publisher
    ..Here, we show that the leukocyte activation antigen CD69 limits differentiation into proinflammatory helper T cells (Th17 cells)...
  19. Grigorova I, Panteleev M, Cyster J. Lymph node cortical sinus organization and relationship to lymphocyte egress dynamics and antigen exposure. Proc Natl Acad Sci U S A. 2010;107:20447-52 pubmed publisher
    ..However, upon entry to inflamed LNs, lymphocytes rapidly up-regulate CD69 and are prevented from accessing cortical sinuses...
  20. Nakayama T, Kasprowicz D, Yamashita M, Schubert L, Gillard G, Kimura M, et al. The generation of mature, single-positive thymocytes in vivo is dysregulated by CD69 blockade or overexpression. J Immunol. 2002;168:87-94 pubmed
    ..One of the hallmarks of this maturation process is the expression of CD69, which first appears on thymocytes as they begin positive selection...
  21. Cruz Adalia A, Jiménez Borreguero L, Ramírez Huesca M, Chico Calero I, Barreiro O, López Conesa E, et al. CD69 limits the severity of cardiomyopathy after autoimmune myocarditis. Circulation. 2010;122:1396-404 pubmed publisher
    ..Different data indicate that CD69 exerts an important immunoregulatory effect in vivo...
  22. Wang L, Wildt K, Zhu J, Zhang X, Feigenbaum L, Tessarollo L, et al. Distinct functions for the transcription factors GATA-3 and ThPOK during intrathymic differentiation of CD4(+) T cells. Nat Immunol. 2008;9:1122-30 pubmed publisher
    ..We propose that GATA-3 acts as a specification factor for the CD4(+) lineage 'upstream' of the ThPOK-controlled CD4(+) commitment checkpoint. ..
  23. Alari Pahissa E, Notario L, Lorente E, Vega Ramos J, Justel A, Lopez D, et al. CD69 does not affect the extent of T cell priming. PLoS ONE. 2012;7:e48593 pubmed publisher
    b>CD69 is rapidly upregulated on T cells upon activation. In this work we show that this is also the case for CD69 expression on dendritic cells (DC)...
  24. Borges O, Borchard G, de Sousa A, Junginger H, Cordeiro da Silva A. Induction of lymphocytes activated marker CD69 following exposure to chitosan and alginate biopolymers. Int J Pharm. 2007;337:254-64 pubmed
    b>CD69 is a very early cell activation antigen expressed on the surface of activated immune cells. It can appear within 1-2h of activation and exhibits maximal expression levels between 18 and 24h after stimulation...
  25. Kai T, Yamazaki T, Arai S, Miyazaki T. Stabilization and augmentation of circulating AIM in mice by synthesized IgM-Fc. PLoS ONE. 2014;9:e97037 pubmed publisher
    ..In view of previous work showing that apoptosis inhibitor of macrophage (AIM) blocks lipid storage in adipocytes, thereby preventing obesity caused by a high-fat diet, we here explored a ..
  26. Martin P, Sanchez Madrid F. CD69: an unexpected regulator of TH17 cell-driven inflammatory responses. Sci Signal. 2011;4:pe14 pubmed publisher
    Mice lacking the C-type lectin receptor CD69 develop exacerbated forms of arthritis, contact dermatitis, allergic asthma, and autoimmune myocarditis...
  27. Motomura Y, Kitamura H, Hijikata A, Matsunaga Y, Matsumoto K, Inoue H, et al. The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells. Nat Immunol. 2011;12:450-9 pubmed publisher
    ..Our results indicate that E4BP4 has multiple functions in controlling the plasticity of IL-13 in T(H)1 cells and IL-10 in T(H)1 cells, T(H)2 cells, T(reg) cells and NKT cells. ..
  28. Ding L, Chen T, Wang X, Zhou L, Shi A, Ning Q. CD69+NK cells contribute to the murine hepatitis virus strain 3-induced murine hepatitis. J Huazhong Univ Sci Technolog Med Sci. 2013;33:505-510 pubmed publisher
    The role of hepatic CD69+ natural killer (NK) cells in virus-induced severe liver injury and subsequent hepatic failure is not well defined...
  29. Park H, Staehling Hampton K, Appleby M, Brunkow M, Habib T, Zhang Y, et al. A point mutation in the murine Hem1 gene reveals an essential role for Hematopoietic protein 1 in lymphopoiesis and innate immunity. J Exp Med. 2008;205:2899-913 pubmed publisher
  30. Yamauchi K, Kasuya Y, Kuroda F, Tanaka K, Tsuyusaki J, Ishizaki S, et al. Attenuation of lung inflammation and fibrosis in CD69-deficient mice after intratracheal bleomycin. Respir Res. 2011;12:131 pubmed publisher
    Cluster of differentiation 69 (CD69), an early activation marker antigen on T and B cells, is also expressed on activated macrophages and neutrophils, suggesting that CD69 may play a role in inflammatory diseases...
  31. Radulovic K, Rossini V, Manta C, Holzmann K, Kestler H, Niess J. The early activation marker CD69 regulates the expression of chemokines and CD4 T cell accumulation in intestine. PLoS ONE. 2013;8:e65413 pubmed publisher
    ..b>CD69, the early activation marker of C-type lectin domain family, is also shown to regulate the lymphocyte migration by ..
  32. Ramos Perez W, Fang V, Escalante Alcalde D, Cammer M, Schwab S. A map of the distribution of sphingosine 1-phosphate in the spleen. Nat Immunol. 2015;16:1245-52 pubmed publisher
    ..The exquisitely tight regulation of S1P availability might explain how a single lipid can simultaneously orchestrate the movements of many cells of the immune system. ..
  33. Brändle D, Muller S, Muller C, Hengartner H, Pircher H. Regulation of RAG-1 and CD69 expression in the thymus during positive and negative selection. Eur J Immunol. 1994;24:145-51 pubmed
    ..Cytofluorometric analysis further revealed that surface expression of CD69 on immature thymocytes inversely correlated with RAG-1 expression during positive and negative selection processes.
  34. Stegmann K, de Souza J, Riley E. IL-18-induced expression of high-affinity IL-2R on murine NK cells is essential for NK-cell IFN-γ production during murine Plasmodium yoelii infection. Eur J Immunol. 2015;45:3431-40 pubmed publisher
    ..These data suggest that IL-2 signaling via CD25 amplifies IL-18- and IL-12-mediated NK-cell activation during malaria infection. ..
  35. Lamana A, Sancho D, Cruz Adalia A, Del Hoyo G, Herrera A, Feria M, et al. The role of CD69 in acute neutrophil-mediated inflammation. Eur J Immunol. 2006;36:2632-8 pubmed
    The leukocyte activation marker CD69 functions as a negative regulator of the immune response, both in NK-dependent tumor rejection and in the inflammation associated with lymphocyte-dependent collagen-induced arthritis...
  36. Cortes J, Sánchez Díaz R, Bovolenta E, Barreiro O, Lasarte S, Matesanz Marín A, et al. Maintenance of immune tolerance by Foxp3+ regulatory T cells requires CD69 expression. J Autoimmun. 2014;55:51-62 pubmed publisher
    ..In this study, we have investigated the role of the C-type lectin receptor CD69 in the suppressor function of Tregs and maintenance of immune tolerance towards harmless inhaled antigens...
  37. Gyetko M, Libre E, Fuller J, Chen G, Toews G. Urokinase is required for T lymphocyte proliferation and activation in vitro. J Lab Clin Med. 1999;133:274-88 pubmed
    ..The expression of CD69 and that of CD49d were diminished in response to Con A stimulation in uPA-/- mice as compared with uPA+/+ mice...
  38. Fang V, Chaluvadi V, Ramos Perez W, Mendoza A, Baeyens A, Rivera R, et al. Gradients of the signaling lipid S1P in lymph nodes position natural killer cells and regulate their interferon-? response. Nat Immunol. 2017;18:15-25 pubmed publisher
    ..Our findings elucidate the spatial cues for NK cell organization and reveal a previously unknown role for S1P in positioning cells within the medulla. ..
  39. Yim D, Sotiriadis J, Kim K, Shin S, Jie H, Rothschild M, et al. Molecular cloning, expression pattern and chromosomal mapping of pig CD69. Immunogenetics. 2002;54:276-81 pubmed
    b>CD69 is a type II membrane protein belonging to C-type lectin family receptor, and expressed on activated leukocytes. Pig CD69 was cloned by RT-PCR using degenerate primers...
  40. Padigel U, Lee J, Nolan T, Schad G, Abraham D. Eosinophils can function as antigen-presenting cells to induce primary and secondary immune responses to Strongyloides stercoralis. Infect Immun. 2006;74:3232-8 pubmed
    ..Antigen-exposed eosinophils showed a sixfold increase in expression levels of CD69 and major histocompatibility complex (MHC) class II, a fourfold increase in levels of T-cell costimulatory molecule ..
  41. Chen Z, Herman A, Matos M, Mathis D, Benoist C. Where CD4+CD25+ T reg cells impinge on autoimmune diabetes. J Exp Med. 2005;202:1387-97 pubmed
    ..Thus, T reg cells primarily impinge on autoimmune diabetes by reining in destructive T cells inside the islets, more than during the initial activation in the draining lymph nodes. ..
  42. Zhang X, Jiang Z, Gu Y, Liu Y, Cao X, Han Y. Inflammation-induced CD69+ Kupffer cell feedback inhibits T cell proliferation via membrane-bound TGF-?1. Sci China Life Sci. 2016;59:1259-1269 pubmed
    ..During L. monocytogenes infection, hepatic CD69+ Kupffer cells were significantly induced and expanded, and CD69+ Kupffer cells expressed ..
  43. Yokoyama W, Koning F, Kehn P, Pereira G, Stingl G, Coligan J, et al. Characterization of a cell surface-expressed disulfide-linked dimer involved in murine T cell activation. J Immunol. 1988;141:369-76 pubmed
    ..These functional and biochemical studies strongly suggest that the Ag recognized by H1.2F3 is the murine homologue of the human CD28 Ag recognized by mAb 9.3. ..
  44. Brown M, Zhang J, Du Y, Stoll J, Yokoyama W, Scalzo A. Localization on a physical map of the NKC-linked Cmv1 locus between Ly49b and the Prp gene cluster on mouse chromosome 6. J Immunol. 1999;163:1991-9 pubmed
    ..This high resolution, integrated physical and genetic NKC map will facilitate identification of Cmv1 and other NKC-linked loci that regulate NK cell-mediated immunity. ..
  45. Fontenot J, Rasmussen J, Gavin M, Rudensky A. A function for interleukin 2 in Foxp3-expressing regulatory T cells. Nat Immunol. 2005;6:1142-51 pubmed
    ..Thus, IL-2 signaling seems to be critically required for maintaining the homeostasis and competitive fitness of T(reg) cells in vivo. ..
  46. Gomez M, Sanz González S, Abu Nabah Y, Lamana A, Sanchez Madrid F, Andres V. Atherosclerosis development in apolipoprotein E-null mice deficient for CD69. Cardiovasc Res. 2009;81:197-205 pubmed publisher
    Atherosclerosis is a chronic inflammatory disease regulated by immune mechanisms. CD69 is a cell surface receptor rapidly induced after leukocyte activation at sites of chronic inflammation...
  47. Tsuyusaki J, Kuroda F, Kasuya Y, Ishizaki S, Yamauchi K, Sugimoto H, et al. Cigarette smoke-induced pulmonary inflammation is attenuated in CD69-deficient mice. J Recept Signal Transduct Res. 2011;31:434-9 pubmed publisher
    Cluster of differentiation 69 (CD69) has been identified as a lymphocyte early activation marker, and recent studies have indicated that CD69 mediates intracellular signals and plays an important role in various inflammatory diseases...
  48. Patel S, Lu Z, Ayi K, Serghides L, Gowda D, Kain K. Disruption of CD36 impairs cytokine response to Plasmodium falciparum glycosylphosphatidylinositol and confers susceptibility to severe and fatal malaria in vivo. J Immunol. 2007;178:3954-61 pubmed
    ..These results provide direct evidence that pfGPI induces TNF-alpha secretion in a CD36-dependent manner and support a role for CD36 in modulating host cytokine response and innate control of acute blood-stage malaria infection in vivo. ..
  49. Kamanaka M, Kim S, Wan Y, Sutterwala F, Lara Tejero M, Galan J, et al. Expression of interleukin-10 in intestinal lymphocytes detected by an interleukin-10 reporter knockin tiger mouse. Immunity. 2006;25:941-52 pubmed
    ..These findings highlight the intestine as a unique site for induction of IL-10-producing T cells, which play a critical role in the regulation of inflammation in the gut. ..
  50. Hara T, Shitara S, Imai K, Miyachi H, Kitano S, Yao H, et al. Identification of IL-7-producing cells in primary and secondary lymphoid organs using IL-7-GFP knock-in mice. J Immunol. 2012;189:1577-84 pubmed publisher
    ..Overall, IL-7-GFP knock-in mice serve as a unique and powerful tool to examine the identity and distribution of IL-7-expressing cells in vivo. ..
  51. Cibrian D, Sáiz M, de la Fuente H, Sánchez Díaz R, Moreno Gonzalo O, Jorge I, et al. CD69 controls the uptake of L-tryptophan through LAT1-CD98 and AhR-dependent secretion of IL-22 in psoriasis. Nat Immunol. 2016;17:985-96 pubmed publisher
    The activation marker CD69 is expressed by skin ?? T cells...
  52. Kimura H, Suzuki M, Konno S, Shindou H, Shimizu T, Nagase T, et al. Orchestrating Role of Apoptosis Inhibitor of Macrophage in the Resolution of Acute Lung Injury. J Immunol. 2017;199:3870-3882 pubmed publisher, we evaluated the significance of a macrophage-derived soluble protein, apoptosis inhibitor of macrophage (AIM), in LPS-induced lung injury in mice...
  53. Mackay L, Braun A, Macleod B, Collins N, Tebartz C, Bedoui S, et al. Cutting edge: CD69 interference with sphingosine-1-phosphate receptor function regulates peripheral T cell retention. J Immunol. 2015;194:2059-63 pubmed publisher
    ..In this study, we analyzed the role of CD69, an early leukocyte activation marker, in regulating effector T cell egress from peripheral tissues...
  54. Marie J, Liggitt D, Rudensky A. Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-beta receptor. Immunity. 2006;25:441-54 pubmed
    ..Thus, TGF-beta signaling in peripheral T cells is crucial in restraining TCR activation-dependent Th1, cytotoxic, and NK cell-like differentiation program which, when left unchecked, leads to rapidly progressing fatal autoimmunity. ..
  55. Takamura S, Yagi H, Hakata Y, Motozono C, McMaster S, Masumoto T, et al. Specific niches for lung-resident memory CD8+ T cells at the site of tissue regeneration enable CD69-independent maintenance. J Exp Med. 2016;213:3057-3073 pubmed
    ..Although CD69 inhibited sphingosine 1-phosphate receptor 1-mediated egress of CD8+ T cells immediately after their ..
  56. Swan D, Kirby J, Ali S. Post-transplant immunosuppression: regulation of the efflux of allospecific effector T cells from lymphoid tissues. PLoS ONE. 2012;7:e45548 pubmed publisher
    ..Longitudinal analysis of CD69 expression showed that almost all T cells expressed this antigen on days 1 and 3 after activation...
  57. de la Fuente H, Cruz Adalia A, Martinez del Hoyo G, Cibrián Vera D, Bonay P, Pérez Hernández D, et al. The leukocyte activation receptor CD69 controls T cell differentiation through its interaction with galectin-1. Mol Cell Biol. 2014;34:2479-87 pubmed publisher
    b>CD69 is involved in immune cell homeostasis, regulating the T cell-mediated immune response through the control of Th17 cell differentiation. However, natural ligands for CD69 have not yet been described...
  58. Vazquez B, Laguna T, Notario L, Lauzurica P. Evidence for an intronic cis-regulatory element within CD69 gene. Genes Immun. 2012;13:356-62 pubmed publisher
    b>CD69 is one of the earliest proteins expressed after leukocyte activation and its engagement is essential in the control of innate and adaptive immune responses...
  59. Scalzo A, Brown M, Chu D, Heusel J, Yokoyama W, Forbes C. Development of intra-natural killer complex (NKC) recombinant and congenic mouse strains for mapping and functional analysis of NK cell regulatory loci. Immunogenetics. 1999;49:238-41 pubmed
  60. Huang L, Chen J, Hong B. [Down-regulation of TIPE2 promotes the proliferation and immune activity of T lymphocytes]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2016;32:886-90 pubmed
    ..Twenty-four hours after transfection with the siRNA into T lymphocytes, the expression of CD69 in each group was detected by flow cytometry...
  61. Notario L, Alari Pahissa E, de Molina A, Lauzurica P. CD69 Deficiency Enhances the Host Response to Vaccinia Virus Infection through Altered NK Cell Homeostasis. J Virol. 2016;90:6464-6474 pubmed publisher
    During the host response to viral infection, the transmembrane CD69 protein is highly upregulated in all immune cells...
  62. Depatie C, Muise E, Lepage P, Gros P, Vidal S. High-resolution linkage map in the proximity of the host resistance locus Cmv1. Genomics. 1997;39:154-63 pubmed
    ..This work demonstrates tight linkage between Cmv1 and genes from the natural killer complex (NKC), such as Nkrp1 and Ly49A, suggesting that Cmv1 may represent an NK cell recognition structure encoded in the NKC region. ..
  63. Siggs O, Yates A, Schlenner S, Liston A, Lesage S, Goodnow C. A ZAP-70 kinase domain variant prevents thymocyte-positive selection despite signalling CD69 induction. Immunology. 2014;141:587-95 pubmed publisher
    ..Unlike cells devoid of ZAP-70, mrtless thymocytes showed partial induction of CD5 and CD69, and were sensitive to TCR stimulation with a dose-response shifted approximately 10-fold...
  64. Lan B, Zhang J, Lu D, Li W. Generation of cancer-specific CD8(+) CD69(+) cells inhibits colon cancer growth. Immunobiology. 2016;221:1-5 pubmed publisher
    ..This study aims to inhibit Cca growth with the in vivo induction of Cca-specific CD8(+) CD69(+) T cell polarization. In this study, a mouse tumor model was created with a mouse colon cancer (Cca) cell line...
  65. Lee Y, Suarez Ramirez J, Wu T, Redman J, Bouchard K, Hadley G, et al. Environmental and antigen receptor-derived signals support sustained surveillance of the lungs by pathogen-specific cytotoxic T lymphocytes. J Virol. 2011;85:4085-94 pubmed publisher
    ..Our studies show that these processed peptide antigens reinforce expression of two homing receptors (CD69 and CD103) which help recently activated virus-specific CTL colonize the lungs during a mild inflammatory response...
  66. Hasegawa A, Iwamura C, Kitajima M, Hashimoto K, Otsuyama K, Ogino H, et al. Crucial role for CD69 in the pathogenesis of dextran sulphate sodium-induced colitis. PLoS ONE. 2013;8:e65494 pubmed publisher
    b>CD69 is a membrane molecule transiently expressed on activated lymphocytes, and its selective expression in inflammatory infiltrates suggests that it plays a role in the pathogenesis of inflammatory diseases...
  67. Kim P, Pai S, Brigl M, Besra G, Gumperz J, Ho I. GATA-3 regulates the development and function of invariant NKT cells. J Immunol. 2006;177:6650-9 pubmed
    ..In addition, GATA-3 is also required for survival, activation, and effector functions of this unique population of T cells. Our data also reveal a previously unidentified peripheral maturation step that is GATA-3 dependent. ..
  68. van Hamburg J, de Bruijn M, Ribeiro de Almeida C, Van Zwam M, van Meurs M, de Haas E, et al. Enforced expression of GATA3 allows differentiation of IL-17-producing cells, but constrains Th17-mediated pathology. Eur J Immunol. 2008;38:2573-86 pubmed publisher
    ..We therefore conclude that although GATA3 allows Th17 differentiation, it acts as an inhibitor of Th17-mediated pathology, through IL-4-dependent and IL-4-independent pathways. ..
  69. Ishikawa S, Arase N, Suenaga T, Saita Y, Noda M, Kuriyama T, et al. Involvement of FcRgamma in signal transduction of osteoclast-associated receptor (OSCAR). Int Immunol. 2004;16:1019-25 pubmed
    ..Furthermore, FcRgamma is required for signal transduction by OSCAR. These findings suggest that the FcRgamma-mediated signal transduction by OSCAR is involved in osteoclast differentiation. ..
  70. Tomura M, Itoh K, Kanagawa O. Naive CD4+ T lymphocytes circulate through lymphoid organs to interact with endogenous antigens and upregulate their function. J Immunol. 2010;184:4646-53 pubmed publisher
    ..The interaction with endogenous Ags transiently induces CD69 expression on T cells, which prolongs retention in the lymphoid organs...