Gene Symbol: Cd63
Description: CD63 antigen
Alias: C75951, ME491, Tspan30, CD63 antigen, melanoma 1 antigen
Species: mouse
Products:     Cd63

Top Publications

  1. Coumailleau F, Das V, Alcover A, Raposo G, Vandormael Pournin S, Le Bras S, et al. Over-expression of Rififylin, a new RING finger and FYVE-like domain-containing protein, inhibits recycling from the endocytic recycling compartment. Mol Biol Cell. 2004;15:4444-56 pubmed
    ..Rffl overexpression represents a novel means to inhibit recycling that will help to understand the mechanisms involved in recycling from the ERC to the plasma membrane. ..
  2. Codina J, Li J, Dubose T. CD63 interacts with the carboxy terminus of the colonic H+-K+-ATPase to decrease [corrected] plasma membrane localization and 86Rb+ uptake. Am J Physiol Cell Physiol. 2005;288:C1279-86 pubmed
    ..The longest identified clone was CD63. To characterize the interaction of CT-HKalpha(2) with CD63, recombinant CT-HKalpha(2) and CD63 were synthesized in ..
  3. Artavanis Tsakonas K, Love J, Ploegh H, Vyas J. Recruitment of CD63 to Cryptococcus neoformans phagosomes requires acidification. Proc Natl Acad Sci U S A. 2006;103:15945-50 pubmed
    The subcellular localization of the cluster of differentiation 63 (CD63) tetraspanin and its interaction with the class II MHC antigen presentation pathway were examined in the context of phagocytosis by live cell imaging, by using ..
  4. Hotta H, Ross A, Huebner K, Isobe M, Wendeborn S, Chao M, et al. Molecular cloning and characterization of an antigen associated with early stages of melanoma tumor progression. Cancer Res. 1988;48:2955-62 pubmed
    The melanoma-associated antigen ME491 is expressed strongly during the early stages of tumor progression...
  5. Banushi B, Forneris F, Straatman Iwanowska A, Strange A, Lyne A, Rogerson C, et al. Regulation of post-Golgi LH3 trafficking is essential for collagen homeostasis. Nat Commun. 2016;7:12111 pubmed publisher
    ..Thus, regulation of post-Golgi LH3 trafficking is essential for collagen homeostasis and for the development and function of multiple organs and tissues. ..
  6. Yoshida N, Kitayama D, Arima M, Sakamoto A, Inamine A, Watanabe Takano H, et al. CXCR4 expression on activated B cells is downregulated by CD63 and IL-21. J Immunol. 2011;186:2800-8 pubmed publisher
    ..The level of CD63 (which recruits CXCR4 to late endosome in CD4 T cells) in centrocytes was more than that in centroblasts and was ..
  7. Schulze U, Brast S, Grabner A, Albiker C, Snieder B, Holle S, et al. Tetraspanin CD63 controls basolateral sorting of organic cation transporter 2 in renal proximal tubules. FASEB J. 2017;31:1421-1433 pubmed publisher
    b>CD63 is a ubiquitously expressed member of the tetraspanin superfamily...
  8. Grünwald B, Harant V, Schaten S, Frühschütz M, Spallek R, Höchst B, et al. Pancreatic Premalignant Lesions Secrete Tissue Inhibitor of Metalloproteinases-1, Which Activates Hepatic Stellate Cells Via CD63 Signaling to Create a Premetastatic Niche in the Liver. Gastroenterology. 2016;151:1011-1024.e7 pubmed publisher
    ..We investigated the role of TIMP1 and its receptor CD63 in metastasis of early-stage pancreatic tumors using mice and human cell lines and tissue samples...
  9. Di Pietro S, Falcon Perez J, Tenza D, Setty S, Marks M, Raposo G, et al. BLOC-1 interacts with BLOC-2 and the AP-3 complex to facilitate protein trafficking on endosomes. Mol Biol Cell. 2006;17:4027-38 pubmed
    ..that BLOC-1 interacts physically and functionally with AP-3 to facilitate the trafficking of a known AP-3 cargo, CD63, and of tyrosinase-related protein 1 (Tyrp1), a melanosomal membrane protein previously thought to traffic only ..

More Information


  1. Nagira M, Imai T, Ishikawa I, Uwabe K, Yoshie O. Mouse homologue of C33 antigen (CD82), a member of the transmembrane 4 superfamily: complementary DNA, genomic structure, and expression. Cell Immunol. 1994;157:144-57 pubmed
    ..e., Tapa-1 (CD81), CD53, and CD63. By mapping the 5' end of CD82 transcripts, we found a single major transcription initiation site 144 bp upstream ..
  2. Hao Z, Li W. Muted protein is involved in the targeting of CD63 to large dense-core vesicles of chromaffin cells. Yi Chuan. 2016;38:718-23 pubmed publisher
    ..b>CD63 is a membrane component of lysosomes and LROs. Whether and how CD63 is sorted into LDCVs is largely unknown...
  3. Seubert B, Cui H, Simonavicius N, Honert K, Schäfer S, Reuning U, et al. Tetraspanin CD63 acts as a pro-metastatic factor via β-catenin stabilization. Int J Cancer. 2015;136:2304-15 pubmed publisher
    The tetraspanin CD63 is implicated in pro-metastatic signaling pathways but, so far, it is unclear, how CD63 levels affect the tumor cell phenotype...
  4. Zou Y, Wang H, Shapiro J, Okamoto C, Brookes S, Lyngstadaas S, et al. Determination of protein regions responsible for interactions of amelogenin with CD63 and LAMP1. Biochem J. 2007;408:347-54 pubmed
    ..Amelogenin interacts with the transmembrane proteins CD63 and LAMP (lysosome-associated membrane protein) 1, which are involved in endocytosis...
  5. van Niel G, Charrin S, Simoes S, Romao M, Rochin L, Saftig P, et al. The tetraspanin CD63 regulates ESCRT-independent and -dependent endosomal sorting during melanogenesis. Dev Cell. 2011;21:708-21 pubmed publisher
    ..Here we show that the tetraspanin CD63 directly participates in ESCRT-independent sorting of the PMEL luminal domain, but not of traditional ESCRT-..
  6. Nomura M, Takihara Y, Shimada K. Isolation and characterization of retinoic acid-inducible cDNA clones in F9 cells: one of the early inducible clones encodes a novel protein sharing several highly homologous regions with a Drosophila polyhomeotic protein. Differentiation. 1994;57:39-50 pubmed
    ..As the Drosophila polyhomeotic gene is involved in regulating morphogenesis, the rae-28 gene may participate in regulating early mammalian development...
  7. Schröder J, Lüllmann Rauch R, Himmerkus N, Pleines I, Nieswandt B, Orinska Z, et al. Deficiency of the tetraspanin CD63 associated with kidney pathology but normal lysosomal function. Mol Cell Biol. 2009;29:1083-94 pubmed publisher
    b>CD63 is a member of the tetraspanin superfamily that constitutes a main component of the lysosomal membrane. In mice, two CD63 gene loci are present, with only one of these two being functional...
  8. Kassahn D, Nachbur U, Conus S, Micheau O, Schneider P, Simon H, et al. Distinct requirements for activation-induced cell surface expression of preformed Fas/CD95 ligand and cytolytic granule markers in T cells. Cell Death Differ. 2009;16:115-24 pubmed publisher
    ..of Fas ligand has distinct requirements and involves different mechanisms than those of the granule markers CD63 and CD107a/Lamp-1...
  9. Higashiyama S, Nanba D. ADAM-mediated ectodomain shedding of HB-EGF in receptor cross-talk. Biochim Biophys Acta. 2005;1751:110-7 pubmed
    ..Here we focus on the ectodomain shedding of HB-EGF by ADAMs, which is not only a key event of receptor cross-talk but also a novel intercellular signaling by the carboxy-terminal fragment (CTF signal). ..
  10. Doyle E, Ridger V, Ferraro F, Turmaine M, Saftig P, Cutler D. CD63 is an essential cofactor to leukocyte recruitment by endothelial P-selectin. Blood. 2011;118:4265-73 pubmed publisher
    ..b>CD63 has long been an established component of WPB, but the functional significance of its presence within an organelle ..
  11. Vyas J, Kim Y, Artavanis Tsakonas K, Love J, van der Veen A, Ploegh H. Tubulation of class II MHC compartments is microtubule dependent and involves multiple endolysosomal membrane proteins in primary dendritic cells. J Immunol. 2007;178:7199-210 pubmed
    ..contain multiple proteins including the class II MHC molecules and LAMP1, a lysosomal resident protein, as well as CD63 and CD82, members of the tetraspanin family...
  12. Miyamoto H, Homma M, Hotta H. Molecular cloning of the murine homologue of CD63/ME491 and detection of its strong expression in the kidney and activated macrophages. Biochim Biophys Acta. 1994;1217:312-6 pubmed
    The mouse homologue of CD63/ME491 (Mu-CD63) was molecularly cloned and analyzed. Mu-CD63 exhibited a strikingly high similarity to CD63/ME491 and the rat homologue...
  13. Harrison Lavoie K, Michaux G, Hewlett L, Kaur J, Hannah M, Lui Roberts W, et al. P-selectin and CD63 use different mechanisms for delivery to Weibel-Palade bodies. Traffic. 2006;7:647-62 pubmed
    ..and AP-3 has previously been shown to play a role in the trafficking of both WPB membrane proteins, P-selectin and CD63. However, WPB are thought to form at the trans Golgi network (TGN), which is inconsistent with a role for AP-3, ..
  14. Xia C, Rahman A, Yang Z, Goldstein L. Chromosomal localization reveals three kinesin heavy chain genes in mouse. Genomics. 1998;52:209-13 pubmed
    ..Kif5a, Kif5b, and Kif5c map to mouse chromosomes 10, 18, and 2; Kif5a and Kif5c appear to be expressed only in neuronal tissues by Northern blot analysis while Kif5b appears to be ubiquitous in its expression. ..
  15. Gwynn B, Eicher E, Peters L. Genetic localization of Cd63, a member of the transmembrane 4 superfamily, reveals two distinct loci in the mouse genome. Genomics. 1996;35:389-91 pubmed
    The membrane protein CD63, a molecular marker for early stages of melanoma progression, has been associated with platelet storage pool deficiency disorders (SPD)...
  16. Seto S, Matsumoto S, Tsujimura K, Koide Y. Differential recruitment of CD63 and Rab7-interacting-lysosomal-protein to phagosomes containing Mycobacterium tuberculosis in macrophages. Microbiol Immunol. 2010;54:170-4 pubmed publisher
    ..Here, it has been demonstrated that a lysosomal glycoprotein, CD63, is recruited to the majority of M.tb phagosomes, while RILP shows limited localization...
  17. Tugues S, Honjo S, König C, Padhan N, Kroon J, Gualandi L, et al. Tetraspanin CD63 promotes vascular endothelial growth factor receptor 2-?1 integrin complex formation, thereby regulating activation and downstream signaling in endothelial cells in vitro and in vivo. J Biol Chem. 2013;288:19060-71 pubmed publisher
    b>CD63 is a member of the transmembrane-4 glycoprotein superfamily (tetraspanins) implicated in the regulation of membrane protein trafficking, leukocyte recruitment, and adhesion processes...
  18. Yang Z, Zimmerman S, Tsunezumi J, Braitsch C, Trent C, Bryant D, et al. Role of CD34 family members in lumen formation in the developing kidney. Dev Biol. 2016;418:66-74 pubmed publisher
  19. Flannery A, Czibener C, Andrews N. Palmitoylation-dependent association with CD63 targets the Ca2+ sensor synaptotagmin VII to lysosomes. J Cell Biol. 2010;191:599-613 pubmed publisher
    ..In macrophages, Syt VII is translocated simultaneously with the lysosomal tetraspanin CD63 from tubular lysosomes to nascent phagosomes in a Ca(2+)-dependent process that facilitates particle uptake...
  20. Kraft S, Jouvin M, Kulkarni N, Kissing S, Morgan E, Dvorak A, et al. The tetraspanin CD63 is required for efficient IgE-mediated mast cell degranulation and anaphylaxis. J Immunol. 2013;191:2871-8 pubmed publisher
    ..Although Abs against the tetraspanins CD63 and CD81 inhibit Fc?RI-induced MC degranulation, the intrinsic role of these molecules in Fc?RI-induced MC ..
  21. Yotsumoto S, Shimada T, Cui C, Nakashima H, Fujiwara H, Ko M. Expression of adrenomedullin, a hypotensive peptide, in the trophoblast giant cells at the embryo implantation site in mouse. Dev Biol. 1998;203:264-75 pubmed