Cd59b

Summary

Gene Symbol: Cd59b
Description: CD59b antigen
Alias: CD59B glycoprotein, MAC-IP, MAC-inhibitory protein, MACIF, membrane attack complex inhibition factor, protectin
Species: mouse
Products:     Cd59b

Top Publications

  1. Qin X, Miwa T, Aktas H, Gao M, Lee C, Qian Y, et al. Genomic structure, functional comparison, and tissue distribution of mouse Cd59a and Cd59b. Mamm Genome. 2001;12:582-9 pubmed
    ..genomic structure, comparative activity, and tissue distribution of these two mouse genes, designated Cd59a and Cd59b. The mouse Cd59 genes encompass a total of 45.6 kb with each gene having four exons...
  2. Qin X, Hu W, Song W, Grubissich L, Hu X, Wu G, et al. Generation and phenotyping of mCd59a and mCd59b double-knockout mice. Am J Hematol. 2009;84:65-70 pubmed publisher
    ..We report here that total abrogation of mCd59 function in mCd59ab(-/-) mice results in complement-mediated hemolytic anemia that is rescued by the deficiency of C3 in compound mCd59ab(-/-)/C3(-/-) mice. ..
  3. Turnberg D, Botto M. The regulation of the complement system: insights from genetically-engineered mice. Mol Immunol. 2003;40:145-53 pubmed
    ..The advantages and disadvantages of this type of approach are discussed and the insights gained from the investigation of these animals are reviewed. ..
  4. Baalasubramanian S, Harris C, Donev R, Mizuno M, Omidvar N, Song W, et al. CD59a is the primary regulator of membrane attack complex assembly in the mouse. J Immunol. 2004;173:3684-92 pubmed
    ..The distribution of the second form, CD59b, was originally described as testis specific, but later by some as widespread...
  5. Qin X, Dobarro M, Bedford S, Ferris S, Miranda P, Song W, et al. Further characterization of reproductive abnormalities in mCd59b knockout mice: a potential new function of mCd59 in male reproduction. J Immunol. 2005;175:6294-302 pubmed
  6. Qin X, Ferris S, Hu W, Guo F, Ziegeler G, Halperin J. Analysis of the promoters and 5'-UTR of mouse Cd59 genes, and of their functional activity in erythrocytes. Genes Immun. 2006;7:287-97 pubmed
    ..Together these findings indicate that the mCd59 genes may have complex and perhaps different regulatory mechanisms in different tissues. ..
  7. Qin X, Hu W, Song W, Blair P, Wu G, Hu X, et al. Balancing role of nitric oxide in complement-mediated activation of platelets from mCd59a and mCd59b double-knockout mice. Am J Hematol. 2009;84:221-7 pubmed publisher
    ..These results indicate that the thrombotic diathesis of PNH patients could be due to a combination of increased complement-mediated platelet activation and reduced NO-bioavailability as a consequence of hemolysis. ..
  8. Wu G, Chen T, Shahsafaei A, Hu W, Bronson R, Shi G, et al. Complement regulator CD59 protects against angiotensin II-induced abdominal aortic aneurysms in mice. Circulation. 2010;121:1338-46 pubmed publisher
    ..Together, these results defined the protective role of CD59 and shed light on the important pathogenic role of the membrane attack complex in abdominal aortic aneurysm. ..
  9. Hu W, Ge X, You T, Xu T, Zhang J, Wu G, et al. Human CD59 inhibitor sensitizes rituximab-resistant lymphoma cells to complement-mediated cytolysis. Cancer Res. 2011;71:2298-307 pubmed publisher
    ..Furthermore, they suggest that preemptive elimination of CD59-overexpressing subpopulations along with rituximab treatment may be a useful approach to ablate or conquer rituximab resistance. ..

More Information

Publications13

  1. Zhang J, Hu W, Xing W, You T, Xu J, Qin X, et al. The protective role of CD59 and pathogenic role of complement in hepatic ischemia and reperfusion injury. Am J Pathol. 2011;179:2876-84 pubmed publisher
    ..Taken together, these results highlight the protective role of CD59 and pathogenic role of complement, including MAC, in the pathogenesis of hepatic IRI. ..
  2. Liu F, Sahoo R, Ge X, Wu L, Ghosh P, Qin X, et al. Deficiency of the complement regulatory protein CD59 accelerates the development of diabetes-induced atherosclerosis in mice. J Diabetes Complications. 2017;31:311-317 pubmed publisher
    ..5%±3.7 vs. 16.4%±3.0; p<0.05) in the aortic roots as compared to their diabetic mCD59 sufficient (mCD59ab+/+/ApoE-/-) counterpart. The deficiency of CD59 accelerates the development of diabetic atherosclerosis. ..
  3. Qian Y, Qin X, Miwa T, Sun X, Halperin J, Song W. Identification and functional characterization of a new gene encoding the mouse terminal complement inhibitor CD59. J Immunol. 2000;165:2528-34 pubmed
    ..we report the discovery and functional characterization of a separate cd59 gene in the mouse (referred to as cd59b, the previously characterized mouse cd59 gene as cd59a)...
  4. Qin X, Krumrei N, Grubissich L, Dobarro M, Aktas H, Perez G, et al. Deficiency of the mouse complement regulatory protein mCd59b results in spontaneous hemolytic anemia with platelet activation and progressive male infertility. Immunity. 2003;18:217-27 pubmed
    ..This work indicates that mCd59b is a key complement regulator in mice and that CD59 is critical in protecting self cells; it also provides a novel model to study complement regulation in human diseases. ..