Genomes and Genes
Gene Symbol: Cd59b
Description: CD59b antigen
Alias: CD59B glycoprotein, MAC-IP, MAC-inhibitory protein, MACIF, membrane attack complex inhibition factor, protectin
- Zhang J, Hu W, Xing W, You T, Xu J, Qin X, et al. The protective role of CD59 and pathogenic role of complement in hepatic ischemia and reperfusion injury. Am J Pathol. 2011;179:2876-84 pubmed publisher..Taken together, these results highlight the protective role of CD59 and pathogenic role of complement, including MAC, in the pathogenesis of hepatic IRI. ..
- Liu F, Sahoo R, Ge X, Wu L, Ghosh P, Qin X, et al. Deficiency of the complement regulatory protein CD59 accelerates the development of diabetes-induced atherosclerosis in mice. J Diabetes Complications. 2017;31:311-317 pubmed publisher..5%±3.7 vs. 16.4%±3.0; p<0.05) in the aortic roots as compared to their diabetic mCD59 sufficient (mCD59ab+/+/ApoE-/-) counterpart. The deficiency of CD59 accelerates the development of diabetic atherosclerosis. ..
- Qian Y, Qin X, Miwa T, Sun X, Halperin J, Song W. Identification and functional characterization of a new gene encoding the mouse terminal complement inhibitor CD59. J Immunol. 2000;165:2528-34 pubmed..we report the discovery and functional characterization of a separate cd59 gene in the mouse (referred to as cd59b, the previously characterized mouse cd59 gene as cd59a)...
- Qin X, Krumrei N, Grubissich L, Dobarro M, Aktas H, Perez G, et al. Deficiency of the mouse complement regulatory protein mCd59b results in spontaneous hemolytic anemia with platelet activation and progressive male infertility. Immunity. 2003;18:217-27 pubmed..This work indicates that mCd59b is a key complement regulator in mice and that CD59 is critical in protecting self cells; it also provides a novel model to study complement regulation in human diseases. ..