Cd59a

Summary

Gene Symbol: Cd59a
Description: CD59a antigen
Alias: AA987121, Cd59, protectin, CD59A glycoprotein, CD59 antigen, MAC-IP, MAC-inhibitory protein, MACIF, membrane attack complex inhibition factor
Species: mouse
Products:     Cd59a

Top Publications

  1. An G, Miwa T, Song W, Lawson J, Rader D, Zhang Y, et al. CD59 but not DAF deficiency accelerates atherosclerosis in female ApoE knockout mice. Mol Immunol. 2009;46:1702-9 pubmed publisher
    ..We studied the role of two membrane complement regulators, decay-accelerating factor (DAF) and CD59, in a murine model of atherosclerosis...
  2. Stahel P, Flierl M, Morgan B, Persigehl I, Stoll C, Conrad C, et al. Absence of the complement regulatory molecule CD59a leads to exacerbated neuropathology after traumatic brain injury in mice. J Neuroinflammation. 2009;6:2 pubmed publisher
    ..Mice deleted in the Cd59a gene (CD59a-/-) and wild-type littermates (n = 60) were subjected to focal closed head injury...
  3. Mead R, Neal J, Griffiths M, Linington C, Botto M, Lassmann H, et al. Deficiency of the complement regulator CD59a enhances disease severity, demyelination and axonal injury in murine acute experimental allergic encephalomyelitis. Lab Invest. 2004;84:21-8 pubmed
    ..we examined the disease course and pathological changes in mice deficient in the major regulator of MAC assembly, CD59a, during the course of acute experimental allergic encephalomyelitis induced by immunisation with recombinant ..
  4. Longhi M, Sivasankar B, Omidvar N, Morgan B, Gallimore A. Cutting edge: murine CD59a modulates antiviral CD4+ T cell activity in a complement-independent manner. J Immunol. 2005;175:7098-102 pubmed
    ..To investigate a role for CD59 in promoting T cell responses, we compared T cell activation in CD59a-deficient (Cd59a-/-) and wild-type (WT) mice after in vitro stimulation and after infection with rVV...
  5. Yun S, Leung V, Botto M, Boyle J, Haskard D. Brief report: accelerated atherosclerosis in low-density lipoprotein receptor-deficient mice lacking the membrane-bound complement regulator CD59. Arterioscler Thromb Vasc Biol. 2008;28:1714-6 pubmed publisher
    ..CD59 gene targeted mice (CD59a(-/-)) mice were crossed with low-density lipoprotein receptor-deficient (Ldlr(-/-)) mice...
  6. Turnberg D, Botto M, Lewis M, Zhou W, Sacks S, Morgan B, et al. CD59a deficiency exacerbates ischemia-reperfusion injury in mice. Am J Pathol. 2004;165:825-32 pubmed
    ..CD59 is the major regulator of membrane attack complex formation. Mice deficient in the Cd59a gene (mCd59a-/-) were used to investigate the role of CD59 in renal ischemia-reperfusion injury...
  7. Ramaglia V, King R, Morgan B, Baas F. Deficiency of the complement regulator CD59a exacerbates Wallerian degeneration. Mol Immunol. 2009;46:1892-6 pubmed publisher
    ..In this study we analyzed the contribution of CD59a, a cell membrane negative regulator of the MAC, to WD...
  8. Zhang J, Hu W, Xing W, You T, Xu J, Qin X, et al. The protective role of CD59 and pathogenic role of complement in hepatic ischemia and reperfusion injury. Am J Pathol. 2011;179:2876-84 pubmed publisher
    ..b>CD59-deficient mice had more severe liver dysfunction, evidenced by increased aspartate aminotransferase levels and ..
  9. Yamada K, Miwa T, Liu J, Nangaku M, Song W. Critical protection from renal ischemia reperfusion injury by CD55 and CD59. J Immunol. 2004;172:3869-75 pubmed
    ..We engineered mice deficient in two membrane complement regulatory proteins, CD55 and CD59, and used them to investigate the role of these endogenous complement inhibitors in renal IRI...

More Information

Publications66

  1. Baalasubramanian S, Harris C, Donev R, Mizuno M, Omidvar N, Song W, et al. CD59a is the primary regulator of membrane attack complex assembly in the mouse. J Immunol. 2004;173:3684-92 pubmed
    ..The first described form of CD59, CD59a, is broadly distributed and deletion of the cd59a gene causes a mild hemolytic phenotype with increased ..
  2. Williams A, Mizuno M, Richards P, Holt D, Morgan B. Deletion of the gene encoding CD59a in mice increases disease severity in a murine model of rheumatoid arthritis. Arthritis Rheum. 2004;50:3035-44 pubmed
    To investigate the roles of CD59a in the protection of joint tissue in the context of murine antigen-induced arthritis (AIA)...
  3. Qin X, Ferris S, Hu W, Guo F, Ziegeler G, Halperin J. Analysis of the promoters and 5'-UTR of mouse Cd59 genes, and of their functional activity in erythrocytes. Genes Immun. 2006;7:287-97 pubmed
    The complement regulatory protein CD59 inhibits formation of the membrane attack complex (MAC), the terminal effector of the complement system. There are two mouse Cd59 genes in mice but only one in humans...
  4. Wu G, Hu W, Shahsafaei A, Song W, Dobarro M, Sukhova G, et al. Complement regulator CD59 protects against atherosclerosis by restricting the formation of complement membrane attack complex. Circ Res. 2009;104:550-8 pubmed publisher
    ..b>CD59 is a key regulator of complement membrane attack complex (MAC) assembly...
  5. Holt D, Botto M, Bygrave A, Hanna S, Walport M, Morgan B. Targeted deletion of the CD59 gene causes spontaneous intravascular hemolysis and hemoglobinuria. Blood. 2001;98:442-9 pubmed
    The glycolipid-anchored glycoprotein CD59 inhibits assembly of the lytic membrane attack complex of complement by incorporation into the forming complex...
  6. Lewis R, Jackson C, Morgan B, Hughes T. The membrane attack complex of complement drives the progression of atherosclerosis in apolipoprotein E knockout mice. Mol Immunol. 2010;47:1098-105 pubmed publisher
    ..C6 (C6(-/-)) deficient and CD59a (Cd59a(-/-)) knockout mice were separately crossed onto the apolipoprotein E knockout (apoE(-/-)) background...
  7. Qin X, Hu W, Song W, Blair P, Wu G, Hu X, et al. Balancing role of nitric oxide in complement-mediated activation of platelets from mCd59a and mCd59b double-knockout mice. Am J Hematol. 2009;84:221-7 pubmed publisher
    b>CD59 is a membrane protein inhibitor of the membrane attack complex (MAC) of complement. mCd59 knockout mice reportedly exhibit hemolytic anemia and platelet activation...
  8. Kent J, Lee M, Schedl A, Boyle S, Fantes J, Powell M, et al. The reticulocalbin gene maps to the WAGR region in human and to the Small eye Harwell deletion in mouse. Genomics. 1997;42:260-7 pubmed
    ..Loss of the reticulocalbin gene could contribute to the early lethality of SeyH and SeyDey homozygotes. ..
  9. Lin F, Salant D, Meyerson H, Emancipator S, Morgan B, Medof M. Respective roles of decay-accelerating factor and CD59 in circumventing glomerular injury in acute nephrotoxic serum nephritis. J Immunol. 2004;172:2636-42 pubmed
    ..We induced nephrotoxic serum (NTS) nephritis in Daf1(-/-), CD59a(-/-), Daf1(-/-)CD59a(-/-), and wild-type (WT) mice by administering NTS IgG...
  10. Qian Y, Qin X, Miwa T, Sun X, Halperin J, Song W. Identification and functional characterization of a new gene encoding the mouse terminal complement inhibitor CD59. J Immunol. 2000;165:2528-34 pubmed
    ..of a separate cd59 gene in the mouse (referred to as cd59b, the previously characterized mouse cd59 gene as cd59a). Mouse cd59b is 85% and 63% identical to cd59a at the nucleotide and amino acid level, respectively...
  11. Powell M, Marchbank K, Rushmere N, van den Berg C, Morgan B. Molecular cloning, chromosomal localization, expression, and functional characterization of the mouse analogue of human CD59. J Immunol. 1997;158:1692-702 pubmed
    We have previously described the isolation and cloning of the rat analogue of the human complement inhibitor CD59 (hCD59). Using the rat CD59 (rCD59) coding region as probe, we have isolated positive cDNAs from a mouse kidney cDNA library...
  12. Hu W, Ge X, You T, Xu T, Zhang J, Wu G, et al. Human CD59 inhibitor sensitizes rituximab-resistant lymphoma cells to complement-mediated cytolysis. Cancer Res. 2011;71:2298-307 pubmed publisher
    Rituximab efficacy in cancer therapy depends in part on induction of complement-dependent cytotoxicity (CDC). Human CD59 (hCD59) is a key complement regulatory protein that restricts the formation of the membrane attack complex, thereby ..
  13. Li Q, Nacion K, Bu H, Lin F. Mouse CD4+ CD25+ T regulatory cells are protected from autologous complement mediated injury by Crry and CD59. Biochem Biophys Res Commun. 2009;382:223-6 pubmed publisher
    ..Instead, all of them express Crry and approximately half of them express CD59. Both Crry(-/-) and CD59(-/-) Treg cells exhibit greater complement mediated injury than WT Treg cells...
  14. Elvington A, Atkinson C, Zhu H, Yu J, Takahashi K, Stahl G, et al. The alternative complement pathway propagates inflammation and injury in murine ischemic stroke. J Immunol. 2012;189:4640-7 pubmed publisher
    ..We additionally show that the protective effect of factor B deficiency and CR2-fH treatment is sustained in the subacute stage of infarct development, adding to the clinical relevance of these findings. ..
  15. Qin X, Miwa T, Aktas H, Gao M, Lee C, Qian Y, et al. Genomic structure, functional comparison, and tissue distribution of mouse Cd59a and Cd59b. Mamm Genome. 2001;12:582-9 pubmed
    ..describe the genomic structure, comparative activity, and tissue distribution of these two mouse genes, designated Cd59a and Cd59b. The mouse Cd59 genes encompass a total of 45.6 kb with each gene having four exons...
  16. Song D, Wilson B, Zhao L, Bhuyan R, Bandyopadhyay M, Lyubarsky A, et al. Retinal Pre-Conditioning by CD59a Knockout Protects against Light-Induced Photoreceptor Degeneration. PLoS ONE. 2016;11:e0166348 pubmed publisher
    ..To test the retinal function of CD59a, a complement inhibitor, CD59a knockout (KO) mice were used for light damage (LD) experiments...
  17. Soltys J, Halperin J, Xuebin Q. DAF/CD55 and Protectin/CD59 modulate adaptive immunity and disease outcome in experimental autoimmune myasthenia gravis. J Neuroimmunol. 2012;244:63-9 pubmed publisher
    The role of regulators of complement activity (RCA) involving CD55 and CD59 in the pathogenesis of experimental autoimmune myasthenia gravis (EAMG) remains unclear...
  18. Wu G, Chen T, Shahsafaei A, Hu W, Bronson R, Shi G, et al. Complement regulator CD59 protects against angiotensin II-induced abdominal aortic aneurysms in mice. Circulation. 2010;121:1338-46 pubmed publisher
    ..Here, we evaluated the pathogenic roles of complement membrane attack complex and CD59, a key regulator that inhibits the membrane attack complex, in the development of abdominal aortic aneurysm...
  19. Miwa T, Zhou L, Hilliard B, Molina H, Song W. Crry, but not CD59 and DAF, is indispensable for murine erythrocyte protection in vivo from spontaneous complement attack. Blood. 2002;99:3707-16 pubmed
    Decay-accelerating factor (DAF) and CD59 are 2 glycosylphosphatidylinositol-anchored membrane proteins that inhibit complement activation at the C3 and C5b-9 step, respectively...
  20. Miwa T, Zhou L, Maldonado M, Madaio M, Eisenberg R, Song W. Absence of CD59 exacerbates systemic autoimmunity in MRL/lpr mice. J Immunol. 2012;189:5434-41 pubmed publisher
    ..We backcrossed the Cd59a knockout (Cd59a(-/-)) mouse onto the MRL/lpr background and compared Cd59a(+/+)-MRL/lpr and Cd59a(-/-)-MRL/lpr ..
  21. Bao L, Haas M, Minto A, Quigg R. Decay-accelerating factor but not CD59 limits experimental immune-complex glomerulonephritis. Lab Invest. 2007;87:357-64 pubmed
    ..Key complement regulatory proteins include decay accelerating factor (DAF) and CD59, which inhibit C3 activation and C5b-9 generation, respectively...
  22. Bora N, Jha P, Lyzogubov V, Kaliappan S, Liu J, Tytarenko R, et al. Recombinant membrane-targeted form of CD59 inhibits the growth of choroidal neovascular complex in mice. J Biol Chem. 2010;285:33826-33 pubmed publisher
    This study was designed to explore the effect of recombinant, membrane-targeted CD59 (rCD59-APT542) on the growth and size of fully developed neovascular complex using the murine model of laser-induced choroidal neovascularization (CNV)...
  23. Bloom A, Collins F, van t Hof R, Ryan E, Jones E, Hughes T, et al. Deletion of the membrane complement inhibitor CD59a drives age and gender-dependent alterations to bone phenotype in mice. Bone. 2016;84:253-261 pubmed publisher
    ..Since CD59a is the principal regulator of the membrane attack complex in mice, we evaluated the impact of CD59a gene deletion ..
  24. Holt D, Powell M, Rushmere N, Morgan B. Genomic structure and chromosome location of the gene encoding mouse CD59. Cytogenet Cell Genet. 2000;89:264-7 pubmed
    The gene encoding the mouse analogue of the human complement regulator CD59 was cloned using a combination of long range PCR and genomic library screening...
  25. Morgan B, Chamberlain Banoub J, Neal J, Song W, Mizuno M, Harris C. The membrane attack pathway of complement drives pathology in passively induced experimental autoimmune myasthenia gravis in mice. Clin Exp Immunol. 2006;146:294-302 pubmed
    ..Mice deficient in the C regulators Daf1 and/or Cd59a were tested in the model...
  26. Wang W, Wang X, Yang L, Fu W, Pan D, Liu J, et al. Modulation of host CD59 expression by varicella-zoster virus in human xenografts in vivo. Virology. 2016;491:96-105 pubmed publisher
    ..Here, we show that expression of CD59, which is a key member of host regulators of complement activation (RCA), is significantly upregulated in response ..
  27. Yang P, Tyrrell J, Han I, Jaffe G. Expression and modulation of RPE cell membrane complement regulatory proteins. Invest Ophthalmol Vis Sci. 2009;50:3473-81 pubmed publisher
    ..Cultured hRPE cell mCRP expression was upregulated by TNF-alpha, IL-1beta, and a repetitive nonlethal dose of HQ. CD59a levels were higher in mouse eyecups than in nonocular tissues...
  28. Marshall K, He S, Zhong Z, Atkinson C, Tomlinson S. Dissecting the complement pathway in hepatic injury and regeneration with a novel protective strategy. J Exp Med. 2014;211:1793-805 pubmed publisher
    ..We describe a novel site-targeted murine complement inhibitor, CR2-CD59, which specifically inhibits the terminal membrane attack complex (MAC), and we use this protein to investigate the ..
  29. Kaminski H, Kusner L, Richmonds C, Medof M, Lin F. Deficiency of decay accelerating factor and CD59 leads to crisis in experimental myasthenia. Exp Neurol. 2006;202:287-93 pubmed
    ..Twenty-four hours after anti-AChR injection, we found that CD59a-/- mice did not significantly differ from WTs, all Daf1-/- CD59a-/- mice either died or required euthanasia...
  30. Turnberg D, Botto M. The regulation of the complement system: insights from genetically-engineered mice. Mol Immunol. 2003;40:145-53 pubmed
    ..The advantages and disadvantages of this type of approach are discussed and the insights gained from the investigation of these animals are reviewed. ..
  31. Ruseva M, Hughes T, Donev R, Sivasankar B, Pickering M, Wu X, et al. Crry deficiency in complement sufficient mice: C3 consumption occurs without associated renal injury. Mol Immunol. 2009;46:803-11 pubmed publisher
  32. Zhang H, Verkman A. Longitudinally extensive NMO spinal cord pathology produced by passive transfer of NMO-IgG in mice lacking complement inhibitor CD59. J Autoimmun. 2014;53:67-77 pubmed publisher
    ..We investigated the involvement of CD59, a glycophosphoinositol (GPI)-anchored membrane protein on astrocytes that inhibits formation of the terminal C5b-9 ..
  33. Longhi M, Williams A, Wise M, Morgan B, Gallimore A. CD59a deficiency exacerbates influenza-induced lung inflammation through complement-dependent and -independent mechanisms. Eur J Immunol. 2007;37:1266-74 pubmed
    ..adaptive immune systems and has been implicated in defence against influenza, the role of the complement regulator CD59a in modulating the response to influenza was explored...
  34. Yin X, Zhou J. [Hepatitis B virus X protein upregulates the expression of CD59 and Crry in mouse podocytes]. Zhonghua Er Ke Za Zhi. 2010;48:934-8 pubmed
    ..The aim of this study was to investigate the influence of hepatitis B x protein (HBx) on the expression of CD59 and Crry in mouse podocytes...
  35. Coles B, Lewis R, Anning P, Morton J, Baalasubramanian S, Morgan B, et al. CD59 or C3 are not requred for angiotensin II-dependent hypertension or hypertrophy in mice. Immunology. 2007;121:518-25 pubmed
    ..Herein, in vivo responses to angiotensin (ang) II were characterized in mice deficient in CD59a or C3. CD59a(-/-) mice had slightly but significantly elevated systolic blood pressure (107.2 +/- 1...
  36. Turnberg D, Lewis M, Moss J, Xu Y, Botto M, Cook H. Complement activation contributes to both glomerular and tubulointerstitial damage in adriamycin nephropathy in mice. J Immunol. 2006;177:4094-102 pubmed
    ..We used mice deficient in C1q, factor D, C3, and CD59, and compared them with strain-matched controls...
  37. Herrmann P, Cowing J, Cristante E, Liyanage S, Ribeiro J, Duran Y, et al. Cd59a deficiency in mice leads to preferential innate immune activation in the retinal pigment epithelium-choroid with age. Neurobiol Aging. 2015;36:2637-48 pubmed publisher
    ..To investigate consequences of altered complement regulation in the eye with age, we examined Cd59a complement regulator deficient (Cd59a(-/-)) mice between 4 and 15 months...
  38. Kinderlerer A, Ali F, Johns M, Lidington E, Leung V, Boyle J, et al. KLF2-dependent, shear stress-induced expression of CD59: a novel cytoprotective mechanism against complement-mediated injury in the vasculature. J Biol Chem. 2008;283:14636-44 pubmed publisher
    ..shear stress led us to explore its influence on endothelial cell expression of complement inhibitory proteins CD59 and decay-accelerating factor...
  39. Harhausen D, Khojasteh U, Stahel P, Morgan B, Nietfeld W, Dirnagl U, et al. Membrane attack complex inhibitor CD59a protects against focal cerebral ischemia in mice. J Neuroinflammation. 2010;7:15 pubmed publisher
    ..Transient focal cerebral ischemia was induced by middle cerebral artery occlusion (MCAO) in young male and female CD59a knockout and wild-type mice...
  40. Qu Z, Liang X, Liu Y, Du J, Liu S, Sun W. Hepatitis B virus sensitizes hepatocytes to complement-dependent cytotoxicity through downregulating CD59. Mol Immunol. 2009;47:283-9 pubmed publisher
    ..b>CD59 mRNA, which encodes an important complement regulatory protein (CRP) expressed on cell surface, was found to be ..
  41. Bao L, Haas M, Pippin J, Wang Y, Miwa T, Chang A, et al. Focal and segmental glomerulosclerosis induced in mice lacking decay-accelerating factor in T cells. J Clin Invest. 2009;119:1264-74 pubmed publisher
    ..BALB/c mice deficient in the key complement regulator, decay-accelerating factor (DAF), but not WT or CD59-deficient BALB/c mice developed histological and ultrastructural features of FSGS, marked albuminuria, ..
  42. Trendelenburg M, Fossati Jimack L, Cortes Hernandez J, Turnberg D, Lewis M, Izui S, et al. The role of complement in cryoglobulin-induced immune complex glomerulonephritis. J Immunol. 2005;175:6909-14 pubmed
    ..It did not correlate with C3 deposition, but did correlate with the amount of C6 deposited. Deficiency of CD59a, the membrane inhibitor of the membrane attack complex, did not induce an increase in neutrophil infiltration, ..
  43. Hu W, Ferris S, Tweten R, Wu G, Radaeva S, Gao B, et al. Rapid conditional targeted ablation of cells expressing human CD59 in transgenic mice by intermedilysin. Nat Med. 2008;14:98-103 pubmed
    ..by Streptococcus intermedius that lyses human cells exclusively, owing to its receptor specificity for human CD59. We generated two transgenic mouse strains that express human CD59 either on erythrocytes (strain ThCD59(RBC)) or ..
  44. González Périz A, Horrillo R, Ferre N, Gronert K, Dong B, Morán Salvador E, et al. Obesity-induced insulin resistance and hepatic steatosis are alleviated by omega-3 fatty acids: a role for resolvins and protectins. FASEB J. 2009;23:1946-57 pubmed publisher
    ..Moreover, representative members of these lipid mediators, namely resolvin E1 and protectin D1, mimicked the insulin-sensitizing and antisteatotic effects of omega-3-PUFAs and induced adiponectin ..
  45. Faber C, Williams J, Juel H, Greenwood J, Nissen M, Moss S. Complement factor H deficiency results in decreased neuroretinal expression of Cd59a in aged mice. Invest Ophthalmol Vis Sci. 2012;53:6324-30 pubmed
    ..C1q, C3, and factor B, in the RPE/choroid coincided with increased expression of the negative regulators Cfh and Cd59a in the neuroretina...
  46. Stumpo D, Broxmeyer H, Ward T, Cooper S, Hangoc G, Chung Y, et al. Targeted disruption of Zfp36l2, encoding a CCCH tandem zinc finger RNA-binding protein, results in defective hematopoiesis. Blood. 2009;114:2401-10 pubmed publisher
    ..These data establish Zfp36l2 as a critical modulator of definitive hematopoiesis and suggest a novel regulatory pathway involving control of mRNA stability in the life cycle of hematopoietic stem and progenitor cells. ..
  47. Qiao F, Atkinson C, Kindy M, Shunmugavel A, Morgan B, Song H, et al. The alternative and terminal pathways of complement mediate post-traumatic spinal cord inflammation and injury. Am J Pathol. 2010;177:3061-70 pubmed publisher
    ..These improvements were associated with decreased C3 and fB deposition. On the other hand, deficiency of CD59, an inhibitor of the membrane attack complex, resulted in significantly increased injury and impaired functional ..
  48. Qin X, Hu W, Song W, Grubissich L, Hu X, Wu G, et al. Generation and phenotyping of mCd59a and mCd59b double-knockout mice. Am J Hematol. 2009;84:65-70 pubmed publisher
    b>CD59 is a membrane protein inhibitor of the membrane attack complex (MAC) of complement. Humans express only one, whereas mice express two CD59 genes...
  49. Kim D, Miwa T, Kimura Y, Schwendener R, van Lookeren Campagne M, Song W. Deficiency of decay-accelerating factor and complement receptor 1-related gene/protein y on murine platelets leads to complement-dependent clearance by the macrophage phagocytic receptor CRIg. Blood. 2008;112:1109-19 pubmed publisher
    ..These results show a critical but redundant role of DAF and Crry in platelet survival and suggest that complement-opsonized platelets and erythrocytes engage different complement receptors on tissue macrophages in vivo. ..
  50. Li B, Chu X, Xu Y, Yang F, Lv C, Nie S. CD59 underlines the antiatherosclerotic effects of C-phycocyanin on mice. Biomed Res Int. 2013;2013:729413 pubmed publisher
    The effects of C-phycocyanin (C-PC) on atherosclerosis and the regulatory effects of CD59 gene on anti-atherosclerotic roles of C-PC were investigated...
  51. Schnabolk G, Tomlinson S, Rohrer B. The complement regulatory protein CD59: insights into attenuation of choroidal neovascularization. Adv Exp Med Biol. 2014;801:435-40 pubmed publisher
    ..membrane attack complex (MAC), the terminal step in the complement cascade, as well as diminished RPE expression of CD59, a membrane-bound regulatory protein of MAC formation...
  52. Sivasankar B, Donev R, Longhi M, Hughes T, Davies R, Cole D, et al. CD59a deficient mice display reduced B cell activity and antibody production in response to T-dependent antigens. Mol Immunol. 2007;44:2978-87 pubmed
    b>CD59a is the primary regulator of membrane attack complex in mice. Recently, we have shown that CD59a-deficient (Cd59a-/-) mice exhibit enhanced CD4+ T cell responses...
  53. Bora N, Kaliappan S, Jha P, Xu Q, Sivasankar B, Harris C, et al. CD59, a complement regulatory protein, controls choroidal neovascularization in a mouse model of wet-type age-related macular degeneration. J Immunol. 2007;178:1783-90 pubmed
    ..CNV was induced by laser photocoagulation in C57BL/6 and Cd59a(-/-) mice using an argon laser. Animals from each group were sacrificed on day 1, 3, 5, and 7 postlaser...
  54. Zhang X, Kimura Y, Fang C, Zhou L, Sfyroera G, Lambris J, et al. Regulation of Toll-like receptor-mediated inflammatory response by complement in vivo. Blood. 2007;110:228-36 pubmed
    ..These results reveal a strong interaction between complement and TLR signaling in vivo and suggest a novel mechanism by which complement promotes inflammation and modulates adaptive immunity. ..
  55. Hitzemann R, Reed C, Malmanger B, Lawler M, Hitzemann B, Cunningham B, et al. On the integration of alcohol-related quantitative trait loci and gene expression analyses. Alcohol Clin Exp Res. 2004;28:1437-48 pubmed
    ..Although improvements are needed in the expression databases, the integration of QTL and gene expression analyses seems to have potential as a high-throughput strategy for moving from QTL to QTG. ..
  56. Miwa T, Sato S, Gullipalli D, Nangaku M, Song W. Blocking properdin, the alternative pathway, and anaphylatoxin receptors ameliorates renal ischemia-reperfusion injury in decay-accelerating factor and CD59 double-knockout mice. J Immunol. 2013;190:3552-9 pubmed publisher
    ..We previously developed a renal IRI model in decay-accelerating factor (DAF) and CD59 double-knockout (DAF(-/-)CD59(-/-)) mice...
  57. Liu F, Sahoo R, Ge X, Wu L, Ghosh P, Qin X, et al. Deficiency of the complement regulatory protein CD59 accelerates the development of diabetes-induced atherosclerosis in mice. J Diabetes Complications. 2017;31:311-317 pubmed publisher
    ..We previously reported that the complement regulatory protein CD59 is inactivated by glycation in humans with diabetes...