Cd55

Summary

Gene Symbol: Cd55
Description: CD55 molecule, decay accelerating factor for complement
Alias: Daf, Daf-GPI, Daf1, GPI-DAF, complement decay-accelerating factor, GPI-anchored, CD55 antigen, Cromer blood group, GPI anchor addition signal, complement-glycosylphosphatidylinositol, decay accelerating factor 1
Species: mouse
Products:     Cd55

Top Publications

  1. Solana M, Ferrer M, Novoa M, Song W, Gomez R. Decay-accelerating factor 1 deficiency exacerbates Trypanosoma cruzi-induced murine chronic myositis. Muscle Nerve. 2012;46:582-7 pubmed publisher
    ..Absence of decay-accelerating factor 1 (Daf1) has been shown to enhance murine T-cell responses and autoimmunity.
  2. Fang C, Miwa T, Shen H, Song W. Complement-dependent enhancement of CD8+ T cell immunity to lymphocytic choriomeningitis virus infection in decay-accelerating factor-deficient mice. J Immunol. 2007;179:3178-86 pubmed
    Decay-accelerating factor (DAF, CD55) is a GPI-anchored membrane protein that regulates complement activation on autologous cells...
  3. Leung V, Yun S, Botto M, Mason J, Malik T, Song W, et al. Decay-accelerating factor suppresses complement C3 activation and retards atherosclerosis in low-density lipoprotein receptor-deficient mice. Am J Pathol. 2009;175:1757-67 pubmed publisher
    Decay-accelerating factor (DAF; CD55) is a membrane protein that regulates complement pathway activity at the level of C3...
  4. Lin F, Spencer D, Hatala D, Levine A, Medof M. Decay-accelerating factor deficiency increases susceptibility to dextran sulfate sodium-induced colitis: role for complement in inflammatory bowel disease. J Immunol. 2004;172:3836-41 pubmed
    ..thus could play a role in IBD pathogenesis, we compared the severity of dextran sulfate sodium-induced colitis in Daf1 gene-targeted and control mice...
  5. Lin F, Salant D, Meyerson H, Emancipator S, Morgan B, Medof M. Respective roles of decay-accelerating factor and CD59 in circumventing glomerular injury in acute nephrotoxic serum nephritis. J Immunol. 2004;172:2636-42 pubmed
    Decay-accelerating factor (DAF or CD55) and CD59 are regulators that protect self cells from C3b deposition and C5b-9 assembly on their surfaces...
  6. Harris C, Rushmere N, Morgan B. Molecular and functional analysis of mouse decay accelerating factor (CD55). Biochem J. 1999;341 ( Pt 3):821-9 pubmed
    Molecular cloning of mouse decay accelerating factor (DAF; CD55) predicted two forms of the molecule, one transmembrane (TM) and the other glycosylphosphatidylinositol (GPI)-anchored; these are encoded by separate genes termed Daf-GPI and ..
  7. Veninga H, Hoek R, de Vos A, de Bruin A, An F, van der Poll T, et al. A novel role for CD55 in granulocyte homeostasis and anti-bacterial host defense. PLoS ONE. 2011;6:e24431 pubmed publisher
    In addition to its complement-regulating activity, CD55 is a ligand of the adhesion class G protein-coupled receptor CD97; however, the relevance of this interaction has remained elusive...
  8. Sogabe H, Nangaku M, Ishibashi Y, Wada T, Fujita T, Sun X, et al. Increased susceptibility of decay-accelerating factor deficient mice to anti-glomerular basement membrane glomerulonephritis. J Immunol. 2001;167:2791-7 pubmed
    ..Decay-accelerating factor (DAF, CD55) is a GPI-linked membrane complement regulator that is widely expressed in mammalian tissues including the kidney...
  9. An G, Miwa T, Song W, Lawson J, Rader D, Zhang Y, et al. CD59 but not DAF deficiency accelerates atherosclerosis in female ApoE knockout mice. Mol Immunol. 2009;46:1702-9 pubmed publisher
    ..We studied the role of two membrane complement regulators, decay-accelerating factor (DAF) and CD59, in a murine model of atherosclerosis...

More Information

Publications76

  1. Molina H, Miwa T, Zhou L, Hilliard B, Mastellos D, Maldonado M, et al. Complement-mediated clearance of erythrocytes: mechanism and delineation of the regulatory roles of Crry and DAF. Decay-accelerating factor. Blood. 2002;100:4544-9 pubmed
    ..C3 regulatory protein, complement receptor 1-related gene/protein y (Crry), but not decay-accelerating factor (DAF), were spontaneously eliminated in vivo by complement...
  2. Miwa T, Sun X, Ohta R, Okada N, Harris C, Morgan B, et al. Characterization of glycosylphosphatidylinositol-anchored decay accelerating factor (GPI-DAF) and transmembrane DAF gene expression in wild-type and GPI-DAF gene knockout mice using polyclonal and monoclonal antibodies with dual or single specificity. Immunology. 2001;104:207-14 pubmed
    Decay-accelerating factor (DAF, CD55) is a glycosylphosphatidylinositol (GPI)-linked membrane inhibitor of complement activation...
  3. Shiraki N, Harada S, Ogaki S, Kume K, Kume S. Identification of DAF1/CD55, a novel definitive endoderm marker. Cell Struct Funct. 2010;35:73-80 pubmed
    ..However, CXCR4 expression decreases in late gut epithelium. Here we report a gene, Decay Accelerating Factor (DAF1/CD55), as a candidate surface marker for the identification of the early and late definitive endoderm...
  4. Lalli P, Strainic M, Lin F, Medof M, Heeger P. Decay accelerating factor can control T cell differentiation into IFN-gamma-producing effector cells via regulating local C5a-induced IL-12 production. J Immunol. 2007;179:5793-802 pubmed
    ..Extending these results, we show that cultures of Marilyn TCR-transgenic T cells stimulated with DAF-deficient (Daf1(-/-)) APCs produce significantly more IL-12, C5a, and IFN-gamma compared with cultures containing wild-type APCs...
  5. Bani Ahmad M, El Amouri I, Ko C, Lin F, Tang Feldman Y, Oakley O. The role of decay accelerating factor in the immunopathogenesis of cytomegalovirus infection. Clin Exp Immunol. 2011;163:199-206 pubmed publisher
    ..Decay accelerating factor (DAF/CD55) is a membrane-bound complement regulatory protein that inhibits the formation and accelerates the decay of C3-..
  6. Sun X, Funk C, Deng C, Sahu A, Lambris J, Song W. Role of decay-accelerating factor in regulating complement activation on the erythrocyte surface as revealed by gene targeting. Proc Natl Acad Sci U S A. 1999;96:628-33 pubmed
    Decay-accelerating factor (DAF) is a glycosylphosphatidylinositol (GPI)-anchored membrane protein that inhibits both the classical and the alternative pathways of complement activation...
  7. Spicer A, Seldin M, Gendler S. Molecular cloning and chromosomal localization of the mouse decay-accelerating factor genes. Duplicated genes encode glycosylphosphatidylinositol-anchored and transmembrane forms. J Immunol. 1995;155:3079-91 pubmed
    ..molecule involved in this regulation is a 70-kDa glycoprotein that has been designated decay-accelerating factor (DAF)...
  8. An F, Li Q, Tu Z, Bu H, Chan C, Caspi R, et al. Role of DAF in protecting against T-cell autoreactivity that leads to experimental autoimmune uveitis. Invest Ophthalmol Vis Sci. 2009;50:3778-82 pubmed publisher
    ..EAU was induced in wild-type (WT) and Daf1(-/-) mice, and their disease severities, IRBP specific Th1/Th17 responses, and cytokine expression profiles were ..
  9. Bao L, Haas M, Pippin J, Wang Y, Miwa T, Chang A, et al. Focal and segmental glomerulosclerosis induced in mice lacking decay-accelerating factor in T cells. J Clin Invest. 2009;119:1264-74 pubmed publisher
    ..BALB/c mice deficient in the key complement regulator, decay-accelerating factor (DAF), but not WT or CD59-deficient BALB/c mice developed histological and ultrastructural features of FSGS, marked ..
  10. Hoek R, de Launay D, Kop E, Yilmaz Elis A, Lin F, Reedquist K, et al. Deletion of either CD55 or CD97 ameliorates arthritis in mouse models. Arthritis Rheum. 2010;62:1036-42 pubmed publisher
    b>CD55 (decay-accelerating factor) is best known for its role in the negative regulation of the complement system. Indeed, lack of this molecule leads to disease aggravation in many autoimmune disease models...
  11. Zhang X, Kimura Y, Fang C, Zhou L, Sfyroera G, Lambris J, et al. Regulation of Toll-like receptor-mediated inflammatory response by complement in vivo. Blood. 2007;110:228-36 pubmed
    ..decreased plasma IL-12 levels in mice deficient in the membrane complement inhibitor decay-accelerating factor (DAF)...
  12. Miwa T, Zhou L, Hilliard B, Molina H, Song W. Crry, but not CD59 and DAF, is indispensable for murine erythrocyte protection in vivo from spontaneous complement attack. Blood. 2002;99:3707-16 pubmed
    Decay-accelerating factor (DAF) and CD59 are 2 glycosylphosphatidylinositol-anchored membrane proteins that inhibit complement activation at the C3 and C5b-9 step, respectively...
  13. Lin F, Fukuoka Y, Spicer A, Ohta R, Okada N, Harris C, et al. Tissue distribution of products of the mouse decay-accelerating factor (DAF) genes. Exploitation of a Daf1 knock-out mouse and site-specific monoclonal antibodies. Immunology. 2001;104:215-25 pubmed
    ..and transmembrane-anchored DAF proteins are produced, each of which can be derived from two different genes (Daf1 and Daf2)...
  14. Miwa T, Maldonado M, Zhou L, Sun X, Luo H, Cai D, et al. Deletion of decay-accelerating factor (CD55) exacerbates autoimmune disease development in MRL/lpr mice. Am J Pathol. 2002;161:1077-86 pubmed
    Decay-accelerating factor (DAF, CD55) is a glycosylphosphatidylinositol-anchored membrane protein that restricts complement activation on autologous cells...
  15. Lin F, Kaminski H, Conti Fine B, Wang W, Richmonds C, Medof M. Markedly enhanced susceptibility to experimental autoimmune myasthenia gravis in the absence of decay-accelerating factor protection. J Clin Invest. 2002;110:1269-74 pubmed
    ..In this study we investigated whether the presence of decay-accelerating factor (DAF or CD55), an intrinsic complement regulator, protects against the development of disease...
  16. Miwa T, Maldonado M, Zhou L, Yamada K, Gilkeson G, Eisenberg R, et al. Decay-accelerating factor ameliorates systemic autoimmune disease in MRL/lpr mice via both complement-dependent and -independent mechanisms. Am J Pathol. 2007;170:1258-66 pubmed
    Decay-accelerating factor (DAF) is a glycosylphosphatidylinositol-anchored membrane protein that restricts complement activation on autologous cells...
  17. Heeger P, Lalli P, Lin F, Valujskikh A, Liu J, Muqim N, et al. Decay-accelerating factor modulates induction of T cell immunity. J Exp Med. 2005;201:1523-30 pubmed
    Decay-accelerating factor (Daf) dissociates C3/C5 convertases that assemble on host cells and thereby prevents complement activation on their surfaces...
  18. Fang C, Zhang X, Miwa T, Song W. Complement promotes the development of inflammatory T-helper 17 cells through synergistic interaction with Toll-like receptor signaling and interleukin-6 production. Blood. 2009;114:1005-15 pubmed publisher
    ..Collectively, these data establish a link between complement/TLR interaction and Th17-cell differentiation and provide new insight into the mechanism of action of complement in autoimmunity. ..
  19. Liu J, Miwa T, Hilliard B, Chen Y, Lambris J, Wells A, et al. The complement inhibitory protein DAF (CD55) suppresses T cell immunity in vivo. J Exp Med. 2005;201:567-77 pubmed
    ..In both C57BL/6 and BALB/c mice, deficiency of the Daf1 gene, which encodes the murine homologue of human DAF, significantly enhanced T cell responses to active ..
  20. Song W, Deng C, Raszmann K, Moore R, Newbold R, McLachlan J, et al. Mouse decay-accelerating factor: selective and tissue-specific induction by estrogen of the gene encoding the glycosylphosphatidylinositol-anchored form. J Immunol. 1996;157:4166-72 pubmed
    ..with the recently reported mouse DAF cDNAs confirmed that the estrogen-inducible gene corresponds to the mouse GPI DAF gene. The induction of mouse DAF by estrogen is tissue specific and can be mimicked by the antiestrogen tamoxifen...
  21. Yamada K, Miwa T, Liu J, Nangaku M, Song W. Critical protection from renal ischemia reperfusion injury by CD55 and CD59. J Immunol. 2004;172:3869-75 pubmed
    ..We engineered mice deficient in two membrane complement regulatory proteins, CD55 and CD59, and used them to investigate the role of these endogenous complement inhibitors in renal IRI...
  22. Cauvi D, Cauvi G, Pollard K. Reduced expression of decay-accelerating factor 1 on CD4+ T cells in murine systemic autoimmune disease. Arthritis Rheum. 2007;56:1934-44 pubmed
    Deficiency of decay-accelerating factor 1 (termed Daf1 in mice) has been shown to exacerbate autoimmunity, and recent studies have suggested that this may be explained by Daf1 acting as a regulator of T cell immunity...
  23. Shimizu I, Smith N, Zhao G, Medof E, Sykes M. Decay-accelerating factor prevents acute humoral rejection induced by low levels of anti-alphaGal natural antibodies. Transplantation. 2006;81:95-100 pubmed
    ..b>DAF1-deficient (DAF KO; B6129F2 H-2) mice were used as heart graft donors to alpha1,3-galactosyltransferase deficient (..
  24. Toomey C, Cauvi D, Song W, Pollard K. Decay-accelerating factor 1 (Daf1) deficiency exacerbates xenobiotic-induced autoimmunity. Immunology. 2010;131:99-106 pubmed publisher
    Absence of decay-accelerating factor 1 (Daf1) has been shown to enhance T-cell responses and autoimmunity via increased expression of specific cytokines, most notably interferon (IFN)-gamma...
  25. Pavlov V, Raedler H, Yuan S, Leisman S, Kwan W, Lalli P, et al. Donor deficiency of decay-accelerating factor accelerates murine T cell-mediated cardiac allograft rejection. J Immunol. 2008;181:4580-9 pubmed
    ..Based on our previously delineated link between DAF and CD4 T cell responses, we evaluated the effects of donor Daf1 (the murine homolog of human DAF) deficiency on CD8 T cell-mediated cardiac allograft rejection...
  26. Bao L, Haas M, Minto A, Quigg R. Decay-accelerating factor but not CD59 limits experimental immune-complex glomerulonephritis. Lab Invest. 2007;87:357-64 pubmed
    ..Key complement regulatory proteins include decay accelerating factor (DAF) and CD59, which inhibit C3 activation and C5b-9 generation, respectively...
  27. Miwa T, Zhou L, Tudoran R, Lambris J, Madaio M, Nangaku M, et al. DAF/Crry double deficiency in mice exacerbates nephrotoxic serum-induced proteinuria despite markedly reduced systemic complement activity. Mol Immunol. 2007;44:139-46 pubmed
    Decay-accelerating factor (DAF) and complement receptor 1-related gene/protein y (Crry) are two membrane-anchored complement regulatory proteins in rodent...
  28. Kaminski H, Kusner L, Richmonds C, Medof M, Lin F. Deficiency of decay accelerating factor and CD59 leads to crisis in experimental myasthenia. Exp Neurol. 2006;202:287-93 pubmed
    ..Twenty-four hours after anti-AChR injection, we found that CD59a-/- mice did not significantly differ from WTs, all Daf1-/- CD59a-/- mice either died or required euthanasia...
  29. Veninga H, de Groot D, McCloskey N, Owens B, Dessing M, Verbeek J, et al. CD97 antibody depletes granulocytes in mice under conditions of acute inflammation via a Fc receptor-dependent mechanism. J Leukoc Biol. 2011;89:413-21 pubmed publisher
    ..Applying sterile models of inflammation, intravital microscopy, and mice deficient for the CD97L CD55, the complement component C3, or the FcR common ?-chain, we show that 1B2 acts in vivo independent of ligand-..
  30. Fukuoka Y, Yasui A, Okada N, Okada H. Molecular cloning of murine decay accelerating factor by immunoscreening. Int Immunol. 1996;8:379-85 pubmed
    Although the cDNA of human decay accelerating factor (DAF) which restricts complement activation on homologous cell membranes was cloned in 1987, all trials to detect the cDNA of mouse DAF by cross-hybridization were unsuccessful...
  31. Kinderlerer A, Pombo Gregoire I, Hamdulay S, Ali F, Steinberg R, Silva G, et al. Heme oxygenase-1 expression enhances vascular endothelial resistance to complement-mediated injury through induction of decay-accelerating factor: a role for increased bilirubin and ferritin. Blood. 2009;113:1598-607 pubmed publisher
    ..action, the regulation of complement activation, mediated via induction of decay-accelerating factor (DAF)...
  32. Lewis R, Perry M, Guschina I, Jackson C, Morgan B, Hughes T. CD55 deficiency protects against atherosclerosis in ApoE-deficient mice via C3a modulation of lipid metabolism. Am J Pathol. 2011;179:1601-7 pubmed publisher
    ..We examined the role of CD55, a membrane inhibitor of the complement component 3 (C3) convertase, which converts C3 into C3a and C3b, in ..
  33. Pandya P, Fisher A, Mickler E, Temm C, Lipking K, Gracon A, et al. Hypoxia-Inducible Factor-1α Regulates CD55 in Airway Epithelium. Am J Respir Cell Mol Biol. 2016;55:889-898 pubmed
    Airway epithelial CD55 down-regulation occurs in several hypoxia-associated pulmonary diseases, but the mechanism is unknown...
  34. Turnberg D, Botto M. The regulation of the complement system: insights from genetically-engineered mice. Mol Immunol. 2003;40:145-53 pubmed
    ..The advantages and disadvantages of this type of approach are discussed and the insights gained from the investigation of these animals are reviewed. ..
  35. Spiller O, Goodfellow I, Evans D, Almond J, Morgan B. Echoviruses and coxsackie B viruses that use human decay-accelerating factor (DAF) as a receptor do not bind the rodent analogues of DAF. J Infect Dis. 2000;181:340-3 pubmed
    Many serotypes of echovirus (EV) and Coxsackie B virus (CBV) bind human decay-accelerating factor (DAF) and use it as a receptor for infection...
  36. Miwa T, Zhou L, Maldonado M, Madaio M, Eisenberg R, Song W. Absence of CD59 exacerbates systemic autoimmunity in MRL/lpr mice. J Immunol. 2012;189:5434-41 pubmed publisher
    ..These results together suggest that CD59a inhibits systemic autoimmunity in MRL/lpr mice through a complement-independent mechanism. ..
  37. Lalli P, Strainic M, Yang M, Lin F, Medof M, Heeger P. Locally produced C5a binds to T cell-expressed C5aR to enhance effector T-cell expansion by limiting antigen-induced apoptosis. Blood. 2008;112:1759-66 pubmed publisher
    ..with antigen-presenting cells (APCs) deficient in the complement regulatory protein, decay accelerating factor (DAF), and/or the complement component C3...
  38. O Brien D, Israel D, Krishna U, Romero Gallo J, Nedrud J, Medof M, et al. The role of decay-accelerating factor as a receptor for Helicobacter pylori and a mediator of gastric inflammation. J Biol Chem. 2006;281:13317-23 pubmed
    ..pylori to gastric epithelial cells is critical. Decay-accelerating factor (DAF), a protein that protects epithelial cells from complement-mediated lysis, also functions as a receptor for several ..
  39. Kim J, Oh S, Ahn S, Chung D. IFN-?-producing NKT cells exacerbate sepsis by enhancing C5a generation via IL-10-mediated inhibition of CD55 expression on neutrophils. Eur J Immunol. 2014;44:2025-35 pubmed publisher
    ..Meanwhile, CD1d(-/-) mice exhibited high CD55 expression on neutrophils during sepsis, whereas those cells from WT mice expressed minimal levels of CD55...
  40. Loberg R, Day L, Dunn R, Kalikin L, Pienta K. Inhibition of decay-accelerating factor (CD55) attenuates prostate cancer growth and survival in vivo. Neoplasia. 2006;8:69-78 pubmed
    Decay-accelerating factor (CD55) is a member of membrane-bound complement-regulatory proteins...
  41. Pritchard M, McMullen M, Stavitsky A, Cohen J, Lin F, Edward Medof M, et al. Differential contributions of C3, C5, and decay-accelerating factor to ethanol-induced fatty liver in mice. Gastroenterology. 2007;132:1117-1126 pubmed publisher
    ..or fifth (C5) components of the complement activation pathway, as well as mice lacking decay-accelerating factor (CD55/DAF), a complement regulatory protein, were fed Lieber-DeCarli ethanol-containing diets for 6 weeks or pair-fed ..
  42. Kim D, Miwa T, Song W. Retrovirus-mediated over-expression of decay-accelerating factor rescues Crry-deficient erythrocytes from acute alternative pathway complement attack. J Immunol. 2006;177:5558-66 pubmed
    Decay-accelerating factor (DAF) and complement receptor 1-related gene/protein y (Crry) are two membrane-bound complement regulators on murine erythrocytes that inhibit C3/C5 convertases...
  43. Hillian A, McMullen M, Sebastian B, Roychowdhury S, Rowchowdhury S, Kashyap S, et al. Mice lacking C1q are protected from high fat diet-induced hepatic insulin resistance and impaired glucose homeostasis. J Biol Chem. 2013;288:22565-75 pubmed publisher
    ..early high fat diet-induced hepatic insulin resistance, whereas mice deficient in the negative complement regulator CD55/DAF were more sensitive to the high fat diet...
  44. Soltys J, Halperin J, Xuebin Q. DAF/CD55 and Protectin/CD59 modulate adaptive immunity and disease outcome in experimental autoimmune myasthenia gravis. J Neuroimmunol. 2012;244:63-9 pubmed publisher
    The role of regulators of complement activity (RCA) involving CD55 and CD59 in the pathogenesis of experimental autoimmune myasthenia gravis (EAMG) remains unclear...
  45. Liu J, Lin F, Strainic M, An F, Miller R, Altuntas C, et al. IFN-gamma and IL-17 production in experimental autoimmune encephalomyelitis depends on local APC-T cell complement production. J Immunol. 2008;180:5882-9 pubmed
    ..The results apply to initial generation of the IL-17 phenotype because naive CD62L(high) Daf1(-/-) T cells produce 3-fold more IL-17 in response to TGF-beta and IL-6, whereas CD62L(high) Daf1(-/-)C5aR(-/-)C3aR(..
  46. Karpus O, Veninga H, Hoek R, Flierman D, van Buul J, Vandenakker C, et al. Shear stress-dependent downregulation of the adhesion-G protein-coupled receptor CD97 on circulating leukocytes upon contact with its ligand CD55. J Immunol. 2013;190:3740-8 pubmed publisher
    ..In this study, we investigated the interaction between the pan-leukocyte aGPCR CD97 and its ligand CD55. We found that leukocytes from CD55-deficient mice express significantly increased levels of cell surface CD97 that ..
  47. Nonaka M, Takenaka O, Okada N, Okada H. A new repetitive sequence uniquely present in the decay-accelerating factor genes. Immunogenetics. 1998;47:246-55 pubmed
    The decay-accelerating factor (DAF, CD55) protects cells from autologous complement attack on self cell membranes...
  48. Karpus O, Kiener H, Niederreiter B, Yilmaz Elis A, van der Kaa J, Ramaglia V, et al. CD55 deposited on synovial collagen fibers protects from immune complex-mediated arthritis. Arthritis Res Ther. 2015;17:6 pubmed publisher
    b>CD55, a glycosylphosphatidylinositol-anchored, complement-regulating protein (decay-accelerating factor), is expressed by fibroblast-like synoviocytes (FLS) with high local abundance in the intimal lining layer...
  49. Yu M, Kang K, Bu P, Bell B, Kaul C, Qiao J, et al. Deficiency of CC chemokine ligand 2 and decay-accelerating factor causes retinal degeneration in mice. Exp Eye Res. 2015;138:126-33 pubmed publisher
    ..genes and retinal diseases, we evaluated the retinal phenotype of C57BL/6J mice and mice lacking Ccl2 and/or Daf1 at 12 months of age, using scanning laser ophthalmoscopic imaging, electroretinography (ERG), histology, ..
  50. Irie J, Reck B, Wu Y, Wicker L, Howlett S, Rainbow D, et al. Genome-wide microarray expression analysis of CD4+ T Cells from nonobese diabetic congenic mice identifies Cd55 (Daf1) and Acadl as candidate genes for type 1 diabetes. J Immunol. 2008;180:1071-9 pubmed
    ..differential RNA expression on chromosome 1 were those encoding decay-accelerating factor (DAF, also known as CD55) and acyl-coenzyme A dehydrogenase, long chain, which are located in the Idd5.4 and Idd5.3 regions, respectively...
  51. Esposito A, Suedekum B, Liu J, An F, Lass J, Strainic M, et al. Decay accelerating factor is essential for successful corneal engraftment. Am J Transplant. 2010;10:527-34 pubmed publisher
    ..Here we show that recipient and donor expression of decay accelerating factor (DAF or CD55), a cell surface C3/C5 convertase regulator recently shown to modulate T-cell responses, is essential to sustain ..
  52. Ruseva M, Hughes T, Donev R, Sivasankar B, Pickering M, Wu X, et al. Crry deficiency in complement sufficient mice: C3 consumption occurs without associated renal injury. Mol Immunol. 2009;46:803-11 pubmed publisher
  53. Ji H, Gauguier D, Ohmura K, Gonzalez A, Duchatelle V, Danoy P, et al. Genetic influences on the end-stage effector phase of arthritis. J Exp Med. 2001;194:321-30 pubmed
    ..The clarity of these results argues that our focus on the terminal effector phase of arthritis in the K/BxN model will bear fruit. ..
  54. Lin F, Emancipator S, Salant D, Medof M. Decay-accelerating factor confers protection against complement-mediated podocyte injury in acute nephrotoxic nephritis. Lab Invest. 2002;82:563-9 pubmed
    Decay-accelerating factor (DAF or CD55) is one of a set of regulators that function to protect self cells from deposition of autologous C3b on their surfaces. Its relative importance in vivo, however, is incompletely understood...
  55. Mao D, Wu X, Deppong C, Friend L, Dolecki G, Nelson D, et al. Negligible role of antibodies and C5 in pregnancy loss associated exclusively with C3-dependent mechanisms through complement alternative pathway. Immunity. 2003;19:813-22 pubmed
    ..These findings provide significant insight into the role of the innate immune system in human pregnancy failure, a frequent clinical outcome. ..
  56. Kim D, Miwa T, Kimura Y, Schwendener R, van Lookeren Campagne M, Song W. Deficiency of decay-accelerating factor and complement receptor 1-related gene/protein y on murine platelets leads to complement-dependent clearance by the macrophage phagocytic receptor CRIg. Blood. 2008;112:1109-19 pubmed publisher
    ..We show here that deficiency of either decay-accelerating factor (DAF) or complement receptor 1-related gene/protein y (Crry) on murine platelets was inconsequential, whereas DAF and ..
  57. van Denderen B, Somerville C, Pearse M, Nottle M, Du Z, Shinkel T, et al. Expression of functional decay-accelerating factor in transgenic mice. Transplant Proc. 1995;27:3567-8 pubmed
  58. Vieyra M, Leisman S, Raedler H, Kwan W, Yang M, Strainic M, et al. Complement regulates CD4 T-cell help to CD8 T cells required for murine allograft rejection. Am J Pathol. 2011;179:766-74 pubmed publisher
    ..In contrast, CD4-deficient chimeric mice possessing decay accelerating factor deficient (Daf1(-/-)) bone marrow, in which DC C3a/C5a production is potentiated, acutely reject transplants through a CD8 cell-..
  59. Ogaki S, Omori H, Morooka M, Shiraki N, Ishida S, Kume S. Late stage definitive endodermal differentiation can be defined by Daf1 expression. BMC Dev Biol. 2016;16:19 pubmed publisher
    ..Sox17 and Cxcr4 are useful markers of the DE. Previously, we identified a novel DE marker, Decay accelerating factor 1(Daf1/CD55), by identifying DE specific genes from the expression profile of DE derived from mouse ..
  60. Morgan B, Chamberlain Banoub J, Neal J, Song W, Mizuno M, Harris C. The membrane attack pathway of complement drives pathology in passively induced experimental autoimmune myasthenia gravis in mice. Clin Exp Immunol. 2006;146:294-302 pubmed
    ..Mice deficient in the C regulators Daf1 and/or Cd59a were tested in the model...
  61. van der Touw W, Cravedi P, Kwan W, Paz Artal E, Merad M, Heeger P. Cutting edge: Receptors for C3a and C5a modulate stability of alloantigen-reactive induced regulatory T cells. J Immunol. 2013;190:5921-5 pubmed publisher
  62. Miwa T, Sato S, Gullipalli D, Nangaku M, Song W. Blocking properdin, the alternative pathway, and anaphylatoxin receptors ameliorates renal ischemia-reperfusion injury in decay-accelerating factor and CD59 double-knockout mice. J Immunol. 2013;190:3552-9 pubmed publisher
    ..We previously developed a renal IRI model in decay-accelerating factor (DAF) and CD59 double-knockout (DAF(-/-)CD59(-/-)) mice...
  63. Yang P, Tyrrell J, Han I, Jaffe G. Expression and modulation of RPE cell membrane complement regulatory proteins. Invest Ophthalmol Vis Sci. 2009;50:3473-81 pubmed publisher
    ..Membrane complement regulatory proteins (mCRPs) such as CD46, CD55, and CD59, protect host cells from complement attack...
  64. Nie F, Su D, Shi Y, Chen J, Wang H, Qin W, et al. A preliminary study on the role of the complement regulatory protein, cluster of differentiation 55, in mice with diabetic neuropathic pain. Mol Med Rep. 2015;11:2076-82 pubmed publisher
    ..The aim of this study was to investigate the role of the complement regulatory protein cluster of differentiation 55 (CD55) in the pathogenesis of diabetic neuropathic pain (DNP)...
  65. Barata L, Miwa T, Sato S, Kim D, Mohammed I, Song W. Deletion of Crry and DAF on murine platelets stimulates thrombopoiesis and increases factor H-dependent resistance of peripheral platelets to complement attack. J Immunol. 2013;190:2886-95 pubmed publisher
    Complement receptor 1-related gene/protein y (Crry) and decay-accelerating factor (DAF) are two murine membrane C3 complement regulators with overlapping functions...
  66. Ikeda J, Morii E, Liu Y, Qiu Y, Nakamichi N, Jokoji R, et al. Prognostic significance of CD55 expression in breast cancer. Clin Cancer Res. 2008;14:4780-6 pubmed publisher
    Our recent study revealed that CD55-high population in breast cancer cell line was resistant to apoptosis and formed colonies in vitro more efficiently than CD55-low population...
  67. Fang C, Miwa T, Song W. Decay-accelerating factor regulates T-cell immunity in the context of inflammation by influencing costimulatory molecule expression on antigen-presenting cells. Blood. 2011;118:1008-14 pubmed publisher
    ..Here we studied mice deficient in decay-accelerating factor (DAF), a key membrane complement regulator whose deficiency led to increased complement-dependent T-cell immune ..