Cd40lg

Summary

Gene Symbol: Cd40lg
Description: CD40 ligand
Alias: CD154, CD40-L, Cd40l, HIGM1, IGM, IMD3, Ly-62, Ly62, T-BAM, TRAP, Tnfsf5, Tnlg8b, gp39, CD40 ligand, T-cell antigen Gp39, TNF-related activation protein, tumor necrosis factor ligand 8b, tumor necrosis factor ligand superfamily member 5
Species: mouse
Products:     Cd40lg

Top Publications

  1. Jain A, Kovacs J, Nelson D, Migueles S, Pittaluga S, Fanslow W, et al. Partial immune reconstitution of X-linked hyper IgM syndrome with recombinant CD40 ligand. Blood. 2011;118:3811-7 pubmed publisher
    X-linked hyper IgM syndrome (XHM) is a combined immune deficiency disorder caused by genetic alterations in CD40 ligand. The purpose of this study was to investigate the safety and efficacy of recombinant CD40 ligand (rCD40L) in the ..
  2. Ryu S, Jung K, Yoo H, Kim T, Kim S, Chang J, et al. Cognate CD4 help is essential for the reactivation and expansion of CD8 memory T cells directed against the hematopoietic cell-specific dominant minor histocompatibility antigen, H60. Blood. 2009;113:4273-80 pubmed publisher
    ..Adoptively transferred memory CD8 T cells did not proliferate in CD40L(-/-) hosts...
  3. Mach F, Schonbeck U, Sukhova G, Atkinson E, Libby P. Reduction of atherosclerosis in mice by inhibition of CD40 signalling. Nature. 1998;394:200-3 pubmed
    ..Cells in human atherosclerotic lesions express the immune mediator CD40 and its ligand CD40L (also known as CD154 or gp39)...
  4. Wiesel M, Joller N, Ehlert A, Crouse J, Spörri R, Bachmann M, et al. Th cells act via two synergistic pathways to promote antiviral CD8+ T cell responses. J Immunol. 2010;185:5188-97 pubmed publisher
    ..cells promote vaccinia virus-specific CD8(+) T cell responses via two interconnected synergistic pathways: First, CD40L expressed by activated CD4(+) T cells instructs dendritic cells to produce bioactive IL-12p70, which is directly ..
  5. Hernandez M, Shen L, Rock K. CD40-CD40 ligand interaction between dendritic cells and CD8+ T cells is needed to stimulate maximal T cell responses in the absence of CD4+ T cell help. J Immunol. 2007;178:2844-52 pubmed
    Stimulation of CD40 on APCs through CD40L expressed on helper CD4+ T cells activates and "licenses" the APCs to prime CD8+ T cell responses...
  6. Lee B, Moyron Quiroz J, Rangel Moreno J, Kusser K, Hartson L, Sprague F, et al. CD40, but not CD154, expression on B cells is necessary for optimal primary B cell responses. J Immunol. 2003;171:5707-17 pubmed
    ..The ligand for CD40, CD154, is expressed on activated T cells, NK cells, mast cells, basophils, and even activated B cells...
  7. Andre P, Prasad K, Denis C, He M, Papalia J, Hynes R, et al. CD40L stabilizes arterial thrombi by a beta3 integrin--dependent mechanism. Nat Med. 2002;8:247-52 pubmed
    b>CD40L, a member of the tumor necrosis factor family of ligands, plays a major role in immune responses via its receptor, CD40. Recently, CD40L has been detected on the surfaces of activated platelets and shown to activate endothelium...
  8. Sharma M, Hou D, Baban B, Koni P, He Y, Chandler P, et al. Reprogrammed foxp3(+) regulatory T cells provide essential help to support cross-presentation and CD8(+) T cell priming in naive mice. Immunity. 2010;33:942-54 pubmed publisher
    ..Help from Treg cells was dependent on CD40L, and (unlike help from conventional non-Treg CD4(+) cells) did not require preactivation or prior exposure to ..
  9. Li G, Sanders J, Bevard M, Sun Z, Chumley J, Galkina E, et al. CD40 ligand promotes Mac-1 expression, leukocyte recruitment, and neointima formation after vascular injury. Am J Pathol. 2008;172:1141-52 pubmed publisher
    High levels of circulating soluble CD40 ligand (sCD40L) are frequently found in patients with hypercholesterolemia, diabetes, ischemic stroke, or acute coronary syndromes, predicting an increased rate of atherosclerotic plaque rupture ..

More Information

Publications62

  1. Grewal I, Xu J, Flavell R. Impairment of antigen-specific T-cell priming in mice lacking CD40 ligand. Nature. 1995;378:617-20 pubmed
    Lack of functional expression of CD40 ligand (CD40L) on T cells results in hyper-IgM syndrome (HIGM1), a human immunodeficiency associated with a severely impaired humoral immune response that is consistent with defects in B-cell ..
  2. Sun J, Bevan M. Cutting edge: long-lived CD8 memory and protective immunity in the absence of CD40 expression on CD8 T cells. J Immunol. 2004;172:3385-9 pubmed
    ..Listeria monocytogenes and lymphocytic choriomeningitis virus, we found no evidence of any requirement for CD40-CD40 ligand interaction at this level...
  3. Tan J, Town T, Crawford F, Mori T, DelleDonne A, Crescentini R, et al. Role of CD40 ligand in amyloidosis in transgenic Alzheimer's mice. Nat Neurosci. 2002;5:1288-93 pubmed
    We have shown that interaction of CD40 with CD40L enables microglial activation in response to amyloid-beta peptide (Abeta), which is associated with Alzheimer's disease (AD)-like neuronal tau hyperphosphorylation in vivo...
  4. Kennedy M, Mohler K, Shanebeck K, Baum P, Picha K, Otten Evans C, et al. Induction of B cell costimulatory function by recombinant murine CD40 ligand. Eur J Immunol. 1994;24:116-23 pubmed
    ..of B cell growth and differentiation involves an interaction between CD40, a B cell surface molecule, and the CD40 ligand (CD40L) which is expressed on activated CD4+ T cells...
  5. Koguchi Y, Thauland T, Slifka M, Parker D. Preformed CD40 ligand exists in secretory lysosomes in effector and memory CD4+ T cells and is quickly expressed on the cell surface in an antigen-specific manner. Blood. 2007;110:2520-7 pubmed
    b>CD40 ligand (CD40L) is an essential effector cytokine for macrophage activation, dendritic cell licensing, and T-cell-dependent antibody responses...
  6. Bavendiek U, Zirlik A, LaClair S, MacFarlane L, Libby P, Schonbeck U. Atherogenesis in mice does not require CD40 ligand from bone marrow-derived cells. Arterioscler Thromb Vasc Biol. 2005;25:1244-9 pubmed
    Recent research suggests a central role for CD40 ligand (CD40L) in atherogenesis. However, the relevant cellular source of this proinflammatory cytokine remains unknown...
  7. Jaiswal A, Dubey C, Swain S, Croft M. Regulation of CD40 ligand expression on naive CD4 T cells: a role for TCR but not co-stimulatory signals. Int Immunol. 1996;8:275-85 pubmed
    We have investigated the roles of TCR and accessory co-stimulatory signals in the induction of CD40 ligand (CD40L) on CD4 cells...
  8. Yang Y, Wilson J. CD40 ligand-dependent T cell activation: requirement of B7-CD28 signaling through CD40. Science. 1996;273:1862-4 pubmed
    The role of CD40 ligand (CD40L) in the primary activation of T cells is not clear...
  9. Kweon M, Fujihashi K, Wakatsuki Y, Koga T, Yamamoto M, McGhee J, et al. Mucosally induced systemic T cell unresponsiveness to ovalbumin requires CD40 ligand-CD40 interactions. J Immunol. 1999;162:1904-9 pubmed
    b>CD40 ligand (CD40L) gene-disrupted (CD40L-/-) mice were employed to examine the role of costimulatory signals via CD40L-CD40 interactions in mucosally induced tolerance...
  10. Thomsen A, Nansen A, Christensen J, Andreasen S, Marker O. CD40 ligand is pivotal to efficient control of virus replication in mice infected with lymphocytic choriomeningitis virus. J Immunol. 1998;161:4583-90 pubmed
    b>CD40 ligand (CD40L) is an important molecule that is known to be involved in T-B collaboration and certain aspects of cell-mediated immunity. However, its role in antiviral immunity has not been clearly defined as of yet...
  11. Lesley R, Kelly L, Xu Y, Cyster J. Naive CD4 T cells constitutively express CD40L and augment autoreactive B cell survival. Proc Natl Acad Sci U S A. 2006;103:10717-22 pubmed
    ..Mixed bone marrow chimera experiments reveal that, under homeostatic conditions, the CD40L-CD40 pathway can augment autoreactive B cell survival in a non-cell-autonomous manner...
  12. Howland K, Ausubel L, London C, Abbas A. The roles of CD28 and CD40 ligand in T cell activation and tolerance. J Immunol. 2000;164:4465-70 pubmed
    Costimulation of T cell activation involves both the B7:CD28 as well as the CD40 ligand (CD40L):CD40 pathway...
  13. Moodycliffe A, Shreedhar V, Ullrich S, Walterscheid J, Bucana C, Kripke M, et al. CD40-CD40 ligand interactions in vivo regulate migration of antigen-bearing dendritic cells from the skin to draining lymph nodes. J Exp Med. 2000;191:2011-20 pubmed
    Whereas CD40-CD40 ligand interactions are important for various dendritic cell (DC) functions in vitro, their in vivo relevance is unknown...
  14. Wilson E, Livingstone A. Cutting edge: CD4+ T cell-derived IL-2 is essential for help-dependent primary CD8+ T cell responses. J Immunol. 2008;181:7445-8 pubmed
    ..IL-2-deficient OT-II cells were unable to provide help, although they responded to Ag in vivo and up-regulated CD40 ligand in vitro...
  15. Lee B, Haynes L, Eaton S, Swain S, Randall T. The biological outcome of CD40 signaling is dependent on the duration of CD40 ligand expression: reciprocal regulation by interleukin (IL)-4 and IL-12. J Exp Med. 2002;196:693-704 pubmed
    b>CD40 ligand (CD154) expression on activated T cells can be separated into an early TCR-dependent phase, which occurs between 0 and 24 h after activation, and a later extended phase, which occurs after 24 h and is reciprocally regulated ..
  16. Serra P, Amrani A, Yamanouchi J, Han B, Thiessen S, Utsugi T, et al. CD40 ligation releases immature dendritic cells from the control of regulatory CD4+CD25+ T cells. Immunity. 2003;19:877-89 pubmed
    We report that disruption of CD154 in nonobese diabetic (NOD) mice abrogates the helper function of CD4+CD25- T cells without impairing the regulatory activity of CD4+CD25+ T cells...
  17. Glatman Zaretsky A, Taylor J, King I, Marshall F, Mohrs M, Pearce E. T follicular helper cells differentiate from Th2 cells in response to helminth antigens. J Exp Med. 2009;206:991-9 pubmed publisher
    ..TFH cell development after immunization failed to occur in mice lacking B cells or CD154. The relationship of TFH cells to the Th2 lineage was confirmed when TFH cells were found to develop from CXCR5(-) ..
  18. Vavassori S, Shi Y, Chen C, Ron Y, Covey L. In vivo post-transcriptional regulation of CD154 in mouse CD4+ T cells. Eur J Immunol. 2009;39:2224-32 pubmed publisher
    Interactions between CD40 and its ligand CD154 are involved in the progression of both cell mediated and innate immunity...
  19. Fillatreau S, Gray D. T cell accumulation in B cell follicles is regulated by dendritic cells and is independent of B cell activation. J Exp Med. 2003;197:195-206 pubmed
    ..Crucially, the up-regulation of OX40L (on antigen-presenting cells) and CXCR-5 (on T cells) are CD40-dependent events and we show that T cells do not migrate to follicles in immunized OX40-deficient mice. ..
  20. Martinez Barnetche J, Madrid Marina V, Flavell R, Moreno J. Does CD40 ligation induce B cell negative selection?. J Immunol. 2002;168:1042-9 pubmed
    Binding of CD154 to its receptor, CD40, provides costimulation for mature B cell activation and differentiation in response to Ag receptor signals. In mice, early B cell precursors express CD40, but its function at this stage is unknown...
  21. Armitage R, Fanslow W, Strockbine L, Sato T, Clifford K, Macduff B, et al. Molecular and biological characterization of a murine ligand for CD40. Nature. 1992;357:80-2 pubmed
    ..Here we report the cloning of a ligand for CD40 that is expressed on the cell surface of activated T cells and mediates B-cell proliferation in the absence of co-stimulus, as well as IgE production in the presence of interleukin-4. ..
  22. Seah S, Brady J, Carrington E, Ng W, Sutherland R, Hancock M, et al. Influenza-induced, helper-independent CD8+ T cell responses use CD40 costimulation at the late phase of the primary response. J Leukoc Biol. 2013;93:145-54 pubmed publisher
    The helper-dependent pathway of priming CD8(+) T cells involves "licensing" of DCs by CD40L on CD4(+) T cells...
  23. Whitmire J, Flavell R, Grewal I, Larsen C, Pearson T, Ahmed R. CD40-CD40 ligand costimulation is required for generating antiviral CD4 T cell responses but is dispensable for CD8 T cell responses. J Immunol. 1999;163:3194-201 pubmed
    This study documents a striking dichotomy between CD4 and CD8 T cells in terms of their requirements for CD40-CD40 ligand (CD40L) costimulation...
  24. Graf D, Muller S, Korthauer U, van Kooten C, Weise C, Kroczek R. A soluble form of TRAP (CD40 ligand) is rapidly released after T cell activation. Eur J Immunol. 1995;25:1749-54 pubmed
    b>TRAP is a tumor necrosis factor (TNF)-related, 33-kDa type II transmembrane protein almost exclusively expressed on the surface of activated CD4+ T lymphocytes...
  25. Han S, Hathcock K, Zheng B, Kepler T, Hodes R, Kelsoe G. Cellular interaction in germinal centers. Roles of CD40 ligand and B7-2 in established germinal centers. J Immunol. 1995;155:556-67 pubmed
    ..compared the roles of CD40L and B7-2 in the initiation and maturation of humoral immunity by administering anti-CD40 ligand (L) or anti-B7-2 Ab during the early (days -1 to 3) or late (days 6-10) phases of primary responses to thymus-..
  26. Borrow P, Tishon A, Lee S, Xu J, Grewal I, Oldstone M, et al. CD40L-deficient mice show deficits in antiviral immunity and have an impaired memory CD8+ CTL response. J Exp Med. 1996;183:2129-42 pubmed
    The ligand for CD40 (CD40L) is expressed on the surface of activated CD4+ T cells and its role in T-B cell collaborations and thymus-dependent humoral immunity is well established...
  27. Buhlmann J, Gonzalez M, Ginther B, Panoskaltsis Mortari A, Blazar B, Greiner D, et al. Cutting edge: sustained expansion of CD8+ T cells requires CD154 expression by Th cells in acute graft versus host disease. J Immunol. 1999;162:4373-6 pubmed
    ..We extend these data to show that in the absence of CD154 function, donor T cells are unable to expand or generate high level anti-host CTL activity...
  28. Akiyama T, Shimo Y, Yanai H, Qin J, Ohshima D, Maruyama Y, et al. The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance. Immunity. 2008;29:423-37 pubmed publisher
    ..These results show that developmental-stage-dependent cooperation between RANK and CD40 promotes mTEC development, thereby establishing self-tolerance. ..
  29. Lievens D, Zernecke A, Seijkens T, Soehnlein O, Beckers L, Munnix I, et al. Platelet CD40L mediates thrombotic and inflammatory processes in atherosclerosis. Blood. 2010;116:4317-27 pubmed publisher
    b>CD40 ligand (CD40L), identified as a costimulatory molecule expressed on T cells, is also expressed and functional on platelets. We investigated the thrombotic and inflammatory contributions of platelet CD40L in atherosclerosis...
  30. Grewal I, Foellmer H, Grewal K, Xu J, Hardardottir F, Baron J, et al. Requirement for CD40 ligand in costimulation induction, T cell activation, and experimental allergic encephalomyelitis. Science. 1996;273:1864-7 pubmed
    The mechanism of CD40 ligand (CD40L)-mediated in vivo activation of CD4(+) T cells was examined by investigation of the development of experimental allergic encephalomyelitis (EAE) in CD40L-deficient mice that carried a transgenic T cell ..
  31. Shedlock D, Whitmire J, Tan J, MacDonald A, Ahmed R, Shen H. Role of CD4 T cell help and costimulation in CD8 T cell responses during Listeria monocytogenes infection. J Immunol. 2003;170:2053-63 pubmed
    CD4 T cells are known to assist the CD8 T cell response by activating APC via CD40-CD40 ligand (L) interactions...
  32. Fujii S, Liu K, Smith C, Bonito A, Steinman R. The linkage of innate to adaptive immunity via maturing dendritic cells in vivo requires CD40 ligation in addition to antigen presentation and CD80/86 costimulation. J Exp Med. 2004;199:1607-18 pubmed
    ..Surprisingly, DCs from CD40(-/-) and CD40L(-/-) mice did not elicit CD4(+) and CD8(+) T cell immunity, even though the DCs exhibited presented ovalbumin on ..
  33. Lineberry N, Su L, Lin J, Coffey G, Seroogy C, Fathman C. Cutting edge: The transmembrane E3 ligase GRAIL ubiquitinates the costimulatory molecule CD40 ligand during the induction of T cell anergy. J Immunol. 2008;181:1622-6 pubmed
    ..ubiquitin ligase GRAIL (gene related to anergy in lymphocytes) regulates expression of the costimulatory molecule CD40L on CD4 T cells...
  34. Koguchi Y, Gardell J, Thauland T, Parker D. Cyclosporine-resistant, Rab27a-independent mobilization of intracellular preformed CD40 ligand mediates antigen-specific T cell help in vitro. J Immunol. 2011;187:626-34 pubmed publisher
    b>CD40L is critically important for the initiation and maintenance of adaptive immune responses. It is generally thought that CD40L expression in CD4(+) T cells is regulated transcriptionally and made from new mRNA following Ag recognition...
  35. Renshaw B, Fanslow W, Armitage R, Campbell K, Liggitt D, Wright B, et al. Humoral immune responses in CD40 ligand-deficient mice. J Exp Med. 1994;180:1889-900 pubmed
    Individuals with X-linked hyper-IgM syndrome fail to express functional CD40 ligand (CD40L) and, as a consequence, are incapable of mounting protective antibody responses to opportunistic bacterial infections...
  36. Villeneuve J, Lepreux S, Mulot A, Berard A, Higa Nishiyama A, Costet P, et al. A protective role for CD154 in hepatic steatosis in mice. Hepatology. 2010;52:1968-79 pubmed publisher
    ..Herein, we studied the role of CD154, a key mediator of inflammation, in hepatic steatosis...
  37. Piguet P, Kan C, Vesin C, Rochat A, Donati Y, Barazzone C. Role of CD40-CVD40L in mouse severe malaria. Am J Pathol. 2001;159:733-42 pubmed
    We explored the role of CD40-CD40L (CD154) in the severe malaria elicited by Plasmodium berghei anka infection in mice...
  38. Soong L, Xu J, Grewal I, Kima P, Sun J, Longley B, et al. Disruption of CD40-CD40 ligand interactions results in an enhanced susceptibility to Leishmania amazonensis infection. Immunity. 1996;4:263-73 pubmed
    To study the role of CD40 ligand (CD40L) in the host immune responses against intracellular pathogens, we infected CD40L knockout (CD40L-/-) mice with Leishmania amazonensis...
  39. Xu J, Foy T, Laman J, Elliott E, Dunn J, Waldschmidt T, et al. Mice deficient for the CD40 ligand. Immunity. 1994;1:423-31 pubmed
    To study the potential roles of CD40L in immune responses, we generated CD40L-deficient mice by gene targeting...
  40. Johnson S, Zhan Y, Sutherland R, Mount A, Bedoui S, Brady J, et al. Selected Toll-like receptor ligands and viruses promote helper-independent cytotoxic T cell priming by upregulating CD40L on dendritic cells. Immunity. 2009;30:218-27 pubmed publisher
    ..CD40L-deficient (Cd40lg(-/-)) DCs are suboptimal both in vivo in bone marrow chimera experiments and in vitro in mixed lymphocyte ..
  41. Vowinkel T, Wood K, Stokes K, Russell J, Krieglstein C, Granger D. Differential expression and regulation of murine CD40 in regional vascular beds. Am J Physiol Heart Circ Physiol. 2006;290:H631-9 pubmed
    There is emerging evidence for a role of the CD40/CD40 ligand (CD40L) dyad as a signaling mechanism in different inflammatory conditions...
  42. Gray D, Seach N, Ueno T, Milton M, Liston A, Lew A, et al. Developmental kinetics, turnover, and stimulatory capacity of thymic epithelial cells. Blood. 2006;108:3777-85 pubmed
    ..Overall, these studies show that the thymic stroma is a surprisingly dynamic population and may have a more direct role in negative selection than previously thought. ..
  43. Lazarevic V, Myers A, Scanga C, Flynn J. CD40, but not CD40L, is required for the optimal priming of T cells and control of aerosol M. tuberculosis infection. Immunity. 2003;19:823-35 pubmed
    ..In contrast, CD40L(-/-) mice were resistant to M. tuberculosis...
  44. Yacoub D, Hachem A, Théorêt J, Gillis M, Mourad W, Merhi Y. Enhanced levels of soluble CD40 ligand exacerbate platelet aggregation and thrombus formation through a CD40-dependent tumor necrosis factor receptor-associated factor-2/Rac1/p38 mitogen-activated protein kinase signaling pathway. Arterioscler Thromb Vasc Biol. 2010;30:2424-33 pubmed publisher
    b>CD40 ligand is a thromboinflammatory molecule that predicts cardiovascular events...
  45. Hristov M, Gümbel D, Lutgens E, Zernecke A, Weber C. Soluble CD40 ligand impairs the function of peripheral blood angiogenic outgrowth cells and increases neointimal formation after arterial injury. Circulation. 2010;121:315-24 pubmed publisher
    Recent work has revealed an essential involvement of soluble CD40 ligand (sCD40L) in inflammation and atherosclerosis...
  46. De Santo C, Salio M, Masri S, Lee L, Dong T, Speak A, et al. Invariant NKT cells reduce the immunosuppressive activity of influenza A virus-induced myeloid-derived suppressor cells in mice and humans. J Clin Invest. 2008;118:4036-48 pubmed publisher
    ..These findings identify what we believe to be a novel immunomodulatory role of iNKT cells, which we suggest could be harnessed to abolish the immunosuppressive activity of MDSCs during IAV infection. ..
  47. Wong K, Lew F, Macary P, Kemeny D. CD40L-expressing CD8 T cells prime CD8alpha(+) DC for IL-12p70 production. Eur J Immunol. 2008;38:2251-62 pubmed publisher
    ..Activated CD8 T cells use a combination of IFN-gamma and CD40L, which is rapidly up-regulated post-stimulation, to prime DC for IL-12p70 production during an antigen-specific ..
  48. Leadbetter E, Brigl M, Illarionov P, Cohen N, Luteran M, Pillai S, et al. NK T cells provide lipid antigen-specific cognate help for B cells. Proc Natl Acad Sci U S A. 2008;105:8339-44 pubmed publisher
    ..B cells is shown to involve cognate help from CD1d-instructed lipid-specific iNK T cells, with help provided via CD40L, B7-1/B7-2, and IFN-gamma, but not IL-4...
  49. Hermans I, Silk J, Gileadi U, Salio M, Mathew B, Ritter G, et al. NKT cells enhance CD4+ and CD8+ T cell responses to soluble antigen in vivo through direct interaction with dendritic cells. J Immunol. 2003;171:5140-7 pubmed
    ..Thus, iNKT cells exert a significant influence on the efficacy of immune responses to soluble Ag by modulating DC function. ..
  50. Gaspal F, McConnell F, Kim M, Gray D, Kosco Vilbois M, Raykundalia C, et al. The generation of thymus-independent germinal centers depends on CD40 but not on CD154, the T cell-derived CD40-ligand. Eur J Immunol. 2006;36:1665-73 pubmed
    ..type 2 antigens in mice depends on intact signals through CD40, but does not depend on T cell-derived CD40-ligand (CD154)...
  51. Li W, Carlson T, Green W. Stimulation-dependent induction of CD154 on a subset of CD4+ FoxP3+ T-regulatory cells. Int Immunopharmacol. 2011;11:1205-10 pubmed publisher
    CD40-ligand/CD154 is predominantly expressed on activated CD4 T cells and plays a central role in regulating CD4 T-cell-dependent responses...
  52. Davidson D, Hirschman M, Sun A, Singh M, Kasischke K, Maggirwar S. Excess soluble CD40L contributes to blood brain barrier permeability in vivo: implications for HIV-associated neurocognitive disorders. PLoS ONE. 2012;7:e51793 pubmed publisher
    ..Consistently, we have previously shown that levels of the inflammatory mediator soluble CD40L (sCD40L) are elevated in the circulation of HIV-infected, cognitively impaired individuals as compared to their ..
  53. Andreasen S, Christensen J, Marker O, Thomsen A. Role of CD40 ligand and CD28 in induction and maintenance of antiviral CD8+ effector T cell responses. J Immunol. 2000;164:3689-97 pubmed
    The primary aim of this report was to evaluate the immune responses of CD40 ligand-deficient (CD40L-/-) mice infected with two viruses known to differ markedly in their capacity to replicate in the host...