Cd40

Summary

Gene Symbol: Cd40
Description: CD40 antigen
Alias: AI326936, Bp50, GP39, HIGM1, IGM, IMD3, T-BAM, TRAP, Tnfrsf5, p50, tumor necrosis factor receptor superfamily member 5, B-cell surface antigen CD40, CD40L receptor, T-cell differentiation antigen
Species: mouse
Products:     Cd40

Top Publications

  1. Lu L, Ahonen C, Lind E, Raman V, Cook W, Lin L, et al. The in vivo function of a noncanonical TRAF2-binding domain in the C-terminus of CD40 in driving B-cell growth and differentiation. Blood. 2007;110:193-200 pubmed
    The recruitment of tumor necrosis factor receptor-associated factors (TRAFs) 1, 2, 3, 5, and 6 to the CD40 cytoplasmic tail upon CD40 trimerization results in downstream signaling events that ultimately lead to CD40-dependent, thymus-..
  2. Yanaba K, Bouaziz J, Matsushita T, Tsubata T, Tedder T. The development and function of regulatory B cells expressing IL-10 (B10 cells) requires antigen receptor diversity and TLR signals. J Immunol. 2009;182:7459-72 pubmed publisher
    ..However, prolonged LPS or CD40 stimulation (48 h) induced additional adult spleen CD1d(high)CD5(+) B cells to express IL-10 following PMA plus ..
  3. Mathur R, Awasthi A, Wadhone P, Ramanamurthy B, Saha B. Reciprocal CD40 signals through p38MAPK and ERK-1/2 induce counteracting immune responses. Nat Med. 2004;10:540-4 pubmed
    ..Macrophage-expressed CD40, a costimulatory molecule, induces interleukin-12 (IL-12)-dependent and interferon-gamma (IFN-gamma)-dependent host-..
  4. Higuchi T, Aiba Y, Nomura T, Matsuda J, Mochida K, Suzuki M, et al. Cutting Edge: Ectopic expression of CD40 ligand on B cells induces lupus-like autoimmune disease. J Immunol. 2002;168:9-12 pubmed
    b>CD40 ligand (CD40L) is ectopically expressed on B cells in patients with systemic lupus erythematosus (SLE) and lupus-prone BXSB mice...
  5. Munroe M, Bishop G. A costimulatory function for T cell CD40. J Immunol. 2007;178:671-82 pubmed
    b>CD40 plays a significant role in the pathogenesis of inflammation and autoimmunity. B cell CD40 directly activates cells, which can result in autoantibody production...
  6. Koschella M, Voehringer D, Pircher H. CD40 ligation in vivo induces bystander proliferation of memory phenotype CD8 T cells. J Immunol. 2004;172:4804-11 pubmed
    Injection of agonistic anti-CD40 Abs into mice has been shown to amplify weak CD8 T cell responses to poorly immunogenic compounds and to convert T cell tolerance to T cell priming...
  7. Lazarevic V, Myers A, Scanga C, Flynn J. CD40, but not CD40L, is required for the optimal priming of T cells and control of aerosol M. tuberculosis infection. Immunity. 2003;19:823-35 pubmed
    b>CD40(-/-) mice succumbed to low-dose aerosol infection with M. tuberculosis due to deficient IL-12 production leading to impaired priming of IFN-gamma T cell responses. In contrast, CD40L(-/-) mice were resistant to M. tuberculosis...
  8. Ishida T, Mizushima S, Azuma S, Kobayashi N, Tojo T, Suzuki K, et al. Identification of TRAF6, a novel tumor necrosis factor receptor-associated factor protein that mediates signaling from an amino-terminal domain of the CD40 cytoplasmic region. J Biol Chem. 1996;271:28745-8 pubmed
    b>CD40 signalings play crucial roles in B-cell function. To identify molecules which transduce CD40 signalings, we have utilized the yeast two-hybrid system to clone cDNAs encoding proteins that bind the cytoplasmic tail of CD40...
  9. Sudan R, Srivastava N, Pandey S, Majumdar S, Saha B. Reciprocal regulation of protein kinase C isoforms results in differential cellular responsiveness. J Immunol. 2012;188:2328-37 pubmed publisher
    ..As CD40 is the only receptor characterized to trigger counteractive functions, we examined the relative role of PKC ..

More Information

Publications62

  1. Deenick E, Chan A, Ma C, Gatto D, Schwartzberg P, Brink R, et al. Follicular helper T cell differentiation requires continuous antigen presentation that is independent of unique B cell signaling. Immunity. 2010;33:241-53 pubmed publisher
  2. Wong K, Lew F, Macary P, Kemeny D. CD40L-expressing CD8 T cells prime CD8alpha(+) DC for IL-12p70 production. Eur J Immunol. 2008;38:2251-62 pubmed publisher
    ..Our results suggest that the interaction between CD8alpha(+) DC and antigen-primed CD8 T cells may form an important component of Th1-mediated immunity through the induction of IL-12p70. ..
  3. Mizuno T, Rothstein T. B cell receptor (BCR) cross-talk: CD40 engagement enhances BCR-induced ERK activation. J Immunol. 2005;174:3369-76 pubmed
    Bystander B cells may be initially stimulated through CD40, which enhances susceptibility to Fas-mediated apoptosis, before encountering Ag, which produces Fas resistance...
  4. Erickson L, Durell B, Vogel L, O Connor B, Cascalho M, Yasui T, et al. Short-circuiting long-lived humoral immunity by the heightened engagement of CD40. J Clin Invest. 2002;109:613-20 pubmed
    Agonistic alpha CD40 Ab's have been shown to be potent immune adjuvants for both cell- and humoral-mediated immunity...
  5. Hollander G, Castigli E, Kulbacki R, Su M, Burakoff S, Gutierrez Ramos J, et al. Induction of alloantigen-specific tolerance by B cells from CD40-deficient mice. Proc Natl Acad Sci U S A. 1996;93:4994-8 pubmed
    Interaction between CD40 on B cells and CD40 ligand molecules on T cells is pivotal for the generation of a thymus-dependent antibody response...
  6. Hostager B, Bishop G. Cutting edge: contrasting roles of TNF receptor-associated factor 2 (TRAF2) and TRAF3 in CD40-activated B lymphocyte differentiation. J Immunol. 1999;162:6307-11 pubmed
    In B lymphocytes, CD40 signals contribute to the activation of Ab secretion, isotype switching, T cell costimulation, and immunological memory...
  7. Wykes M, MacPherson G. Dendritic cell-B-cell interaction: dendritic cells provide B cells with CD40-independent proliferation signals and CD40-dependent survival signals. Immunology. 2000;100:1-3 pubmed
    ..In this study, using B cells and DC from wild type (WT) and CD40 knockout (CD40KO) mice we show that DC initiate proliferation of B cells independently of CD40, because WT or ..
  8. Andrade R, Wessendarp M, Gubbels M, Striepen B, Subauste C. CD40 induces macrophage anti-Toxoplasma gondii activity by triggering autophagy-dependent fusion of pathogen-containing vacuoles and lysosomes. J Clin Invest. 2006;116:2366-77 pubmed
    ..We report that CD40 stimulation of human and mouse macrophages infected with T...
  9. Bolduc A, Long E, Stapler D, Cascalho M, Tsubata T, Koni P, et al. Constitutive CD40L expression on B cells prematurely terminates germinal center response and leads to augmented plasma cell production in T cell areas. J Immunol. 2010;185:220-30 pubmed publisher
    b>CD40/CD40L engagement is essential to T cell-dependent B cell proliferation and differentiation...
  10. Skok J, Poudrier J, Gray D. Dendritic cell-derived IL-12 promotes B cell induction of Th2 differentiation: a feedback regulation of Th1 development. J Immunol. 1999;163:4284-91 pubmed
    ..This capacity is dependent on CD40 as B cells from CD40-/- mice do not elicit Th2 differentiation...
  11. Rowland S, Tremblay M, Ellison J, Stunz L, Bishop G, Hostager B. A novel mechanism for TNFR-associated factor 6-dependent CD40 signaling. J Immunol. 2007;179:4645-53 pubmed
    ..One member of the family critical for efficient activation of T-dependent humoral immune responses is CD40, a cell surface protein expressed by B cells and other APC...
  12. Suzuki M, Zheng X, Zhang X, Ichim T, Sun H, Kubo N, et al. Inhibition of allergic responses by CD40 gene silencing. Allergy. 2009;64:387-97 pubmed publisher
    ..The aim of this study was to evaluate therapeutic effects of CD40 siRNA on inhibition of allergic responses...
  13. Kishi Y, Aiba Y, Higuchi T, Furukawa K, Tokuhisa T, Takemori T, et al. Augmented antibody response with premature germinal center regression in CD40L transgenic mice. J Immunol. 2010;185:211-9 pubmed publisher
    Although CD40 signaling is required for activation and differentiation of B cells, including germinal center (GC) formation and generation of memory B cells, in vivo generation of CD40 signaling augments plasma cell differentiation but ..
  14. Taylor P, Friedman T, Korngold R, Noelle R, Blazar B. Tolerance induction of alloreactive T cells via ex vivo blockade of the CD40:CD40L costimulatory pathway results in the generation of a potent immune regulatory cell. Blood. 2002;99:4601-9 pubmed
    We previously reported that ex vivo blockade of the CD40:CD40L costimulatory pathway in primary mixed lymphocyte reaction cultures resulted in profound in vitro secondary hyporesponsiveness and 30-fold or greater protection from graft-..
  15. Nguyen V, Benveniste E. Critical role of tumor necrosis factor-alpha and NF-kappa B in interferon-gamma -induced CD40 expression in microglia/macrophages. J Biol Chem. 2002;277:13796-803 pubmed
    b>CD40 is a member of the tumor necrosis factor (TNF) receptor superfamily. CD40 expression on antigen-presenting cells (including macrophages and microglia) is crucial for T-cell activation...
  16. Ryu S, Jung K, Yoo H, Kim T, Kim S, Chang J, et al. Cognate CD4 help is essential for the reactivation and expansion of CD8 memory T cells directed against the hematopoietic cell-specific dominant minor histocompatibility antigen, H60. Blood. 2009;113:4273-80 pubmed publisher
    ..Adoptively transferred memory CD8 T cells did not proliferate in CD40L(-/-) hosts. In the CD40(-/-) hosts, marginal memory expansion was detected after priming with male H60 cells but was completely abolished ..
  17. Perona Wright G, Jenkins S, O Connor R, Zienkiewicz D, McSorley H, Maizels R, et al. A pivotal role for CD40-mediated IL-6 production by dendritic cells during IL-17 induction in vivo. J Immunol. 2009;182:2808-15 pubmed publisher
    The costimulatory requirements for Th17 development remain to be defined. In this study, we show that CD40-deficient animals immunized with the gram-positive bacterium Propionibacterium acnes were specifically impaired in their ability to ..
  18. Poe J, Smith S, Haas K, Yanaba K, Tsubata T, Matsushita T, et al. Amplified B lymphocyte CD40 signaling drives regulatory B10 cell expansion in mice. PLoS ONE. 2011;6:e22464 pubmed publisher
    Aberrant CD40 ligand (CD154) expression occurs on both T cells and B cells in human lupus patients, which is suggested to enhance B cell CD40 signaling and play a role in disease pathogenesis...
  19. Andre P, Prasad K, Denis C, He M, Papalia J, Hynes R, et al. CD40L stabilizes arterial thrombi by a beta3 integrin--dependent mechanism. Nat Med. 2002;8:247-52 pubmed
    ..a member of the tumor necrosis factor family of ligands, plays a major role in immune responses via its receptor, CD40. Recently, CD40L has been detected on the surfaces of activated platelets and shown to activate endothelium...
  20. Xie P, Hostager B, Munroe M, Moore C, Bishop G. Cooperation between TNF receptor-associated factors 1 and 2 in CD40 signaling. J Immunol. 2006;176:5388-400 pubmed
    ..a new method for gene targeting by homologous recombination in somatic cells, we produced and studied signaling by CD40 and its viral oncogenic mimic, latent membrane protein 1 (LMP1) in mouse B cell lines lacking TRAF1, TRAF2, or both ..
  21. Bachmann M, Wong B, Josien R, Steinman R, Oxenius A, Choi Y. TRANCE, a tumor necrosis factor family member critical for CD40 ligand-independent T helper cell activation. J Exp Med. 1999;189:1025-31 pubmed
    b>CD40 ligand (CD40L), a tumor necrosis factor (TNF) family member, plays a critical role in antigen-specific T cell responses in vivo...
  22. Mach F, Schonbeck U, Sukhova G, Atkinson E, Libby P. Reduction of atherosclerosis in mice by inhibition of CD40 signalling. Nature. 1998;394:200-3 pubmed
    ..Cells in human atherosclerotic lesions express the immune mediator CD40 and its ligand CD40L (also known as CD154 or gp39)...
  23. Lee B, Moyron Quiroz J, Rangel Moreno J, Kusser K, Hartson L, Sprague F, et al. CD40, but not CD154, expression on B cells is necessary for optimal primary B cell responses. J Immunol. 2003;171:5707-17 pubmed
    b>CD40 is an important costimulatory molecule for B cells as well as dendritic cells, monocytes, and other APCs. The ligand for CD40, CD154, is expressed on activated T cells, NK cells, mast cells, basophils, and even activated B cells...
  24. Guiducci C, Valzasina B, Dislich H, Colombo M. CD40/CD40L interaction regulates CD4+CD25+ T reg homeostasis through dendritic cell-produced IL-2. Eur J Immunol. 2005;35:557-67 pubmed
    ..Treatment of wt mice with Ab blocking CD40/CD40L interaction results in a fast decrease in T reg number that rapidly recovers upon Ab withdrawal...
  25. Kumanogoh A, Wang X, Lee I, Watanabe C, Kamanaka M, Shi W, et al. Increased T cell autoreactivity in the absence of CD40-CD40 ligand interactions: a role of CD40 in regulatory T cell development. J Immunol. 2001;166:353-60 pubmed
    Mutations in the CD40 ligand (CD40L) gene lead to X-linked immunodeficiency with hyper-IgM, which is often associated with autoimmune diseases...
  26. Hollmann A, Gong Q, Owens T. CD40-mediated apoptosis in murine B-lymphoma lines containing mutated p53. Exp Cell Res. 2002;280:201-11 pubmed
    Crosslinking CD40 induces normal B-cells to proliferate and differentiate but causes many tumor cell lines to undergo apoptosis...
  27. Lutgens E, Lievens D, Beckers L, Wijnands E, Soehnlein O, Zernecke A, et al. Deficient CD40-TRAF6 signaling in leukocytes prevents atherosclerosis by skewing the immune response toward an antiinflammatory profile. J Exp Med. 2010;207:391-404 pubmed publisher
    The CD40-CD40 ligand (CD40L) signaling axis plays an important role in immunological pathways. Consequently, this dyad is involved in chronic inflammatory diseases, including atherosclerosis...
  28. Kawamura T, Kanai T, Dohi T, Uraushihara K, Totsuka T, Iiyama R, et al. Ectopic CD40 ligand expression on B cells triggers intestinal inflammation. J Immunol. 2004;172:6388-97 pubmed
    ..study we present evidence that B cells can trigger intestinal inflammation using transgenic (Tg) mice expressing CD40 ligand (CD40L) ectopically on B cells (CD40L/B Tg)...
  29. Hostager B, Fox D, Whitten D, Wilkerson C, Eipper B, Francone V, et al. HOIL-1L interacting protein (HOIP) as an NF-kappaB regulating component of the CD40 signaling complex. PLoS ONE. 2010;5:e11380 pubmed publisher
    ..One family member, CD40, is important for the efficient activation of antibody-producing B cells and other antigen-presenting cells...
  30. Boonstra A, Rajsbaum R, Holman M, Marques R, Asselin Paturel C, Pereira J, et al. Macrophages and myeloid dendritic cells, but not plasmacytoid dendritic cells, produce IL-10 in response to MyD88- and TRIF-dependent TLR signals, and TLR-independent signals. J Immunol. 2006;177:7551-8 pubmed
    ..Toll/IL-1 receptor domain-containing adaptor-dependent TLR signals (TLR3, 4 ligation) as well as non-TLR signals (CD40 ligation) induced macrophages and myeloid DC to produce IL-10 in addition to proinflammatory cytokines...
  31. Hernandez M, Shen L, Rock K. CD40-CD40 ligand interaction between dendritic cells and CD8+ T cells is needed to stimulate maximal T cell responses in the absence of CD4+ T cell help. J Immunol. 2007;178:2844-52 pubmed
    Stimulation of CD40 on APCs through CD40L expressed on helper CD4+ T cells activates and "licenses" the APCs to prime CD8+ T cell responses...
  32. Iezzi G, Sonderegger I, Ampenberger F, Schmitz N, Marsland B, Kopf M. CD40-CD40L cross-talk integrates strong antigenic signals and microbial stimuli to induce development of IL-17-producing CD4+ T cells. Proc Natl Acad Sci U S A. 2009;106:876-81 pubmed publisher
    ..and in vitro systems, we have investigated the role of antigen dose, pathogen-associated molecular patterns, and CD40-CD40 ligand (CD40L) cross-talk in Th17 differentiation...
  33. Tamada K, Tamura H, Flies D, Fu Y, Celis E, Pease L, et al. Blockade of LIGHT/LTbeta and CD40 signaling induces allospecific T cell anergy, preventing graft-versus-host disease. J Clin Invest. 2002;109:549-57 pubmed
    ..Here, we demonstrate that infusion of an mAb against CD40 ligand (CD40L) further increases the efficacy of LTbetaR-Ig, leading to complete prevention of GVHD...
  34. Tomura M, Yu W, Ahn H, Yamashita M, Yang Y, Ono S, et al. A novel function of Valpha14+CD4+NKT cells: stimulation of IL-12 production by antigen-presenting cells in the innate immune system. J Immunol. 1999;163:93-101 pubmed
    ..This study demonstrates that Ag-activated CD4+ NKT cells express CD40 ligand (CD40L) (CD154), which engages CD40 on APC and stimulates them to produce IL-12...
  35. Lee B, Hartson L, Randall T. CD40-deficient, influenza-specific CD8 memory T cells develop and function normally in a CD40-sufficient environment. J Exp Med. 2003;198:1759-64 pubmed
    Two models have been proposed to explain the requirement for CD40 signaling in CD8 T cell responses. The first model suggests that CD4 T cells activate antigen-presenting cells (APCs) through CD40 signaling (APC licensing)...
  36. Kaji T, Ishige A, Hikida M, Taka J, Hijikata A, Kubo M, et al. Distinct cellular pathways select germline-encoded and somatically mutated antibodies into immunological memory. J Exp Med. 2012;209:2079-97 pubmed publisher
  37. Jabara H, Laouini D, Tsitsikov E, Mizoguchi E, Bhan A, Castigli E, et al. The binding site for TRAF2 and TRAF3 but not for TRAF6 is essential for CD40-mediated immunoglobulin class switching. Immunity. 2002;17:265-76 pubmed
    To define the role of TRAF proteins in CD40-dependent isotype switching in B cells, we introduced wild-type (WT) and mutant CD40 transgenes that lacked the binding motifs for TRAF6 (CD40deltaTRAF6), TRAF2 and TRAF3 (CD40deltaTRAF2/3), or ..
  38. Rolink A, Melchers F, Andersson J. The SCID but not the RAG-2 gene product is required for S mu-S epsilon heavy chain class switching. Immunity. 1996;5:319-30 pubmed
    ..B cells from normal (BDF1) and V(D)J recombinase-deficient (RAG-27) or defective (SCID) mice to be induced by a CD40-specific monoclonal antibody and IL-4 to epsilon H chain gene transcription and to S mu-S epsilon switch ..
  39. Ahonen C, Manning E, Erickson L, O CONNOR B, Lind E, Pullen S, et al. The CD40-TRAF6 axis controls affinity maturation and the generation of long-lived plasma cells. Nat Immunol. 2002;3:451-6 pubmed
    ..maturation of the immune response and the generation of long-lived bone marrow (BM) plasma cells are hallmarks of CD40-dependent, thymus-dependent (TD) humoral immunity...
  40. Andrade R, Portillo J, Wessendarp M, Subauste C. CD40 signaling in macrophages induces activity against an intracellular pathogen independently of gamma interferon and reactive nitrogen intermediates. Infect Immun. 2005;73:3115-23 pubmed
    ..Using Toxoplasma gondii as a model, we investigated if CD40 signaling generates mouse macrophages with effector function against an intracellular pathogen despite the absence ..
  41. Vowinkel T, Anthoni C, Wood K, Stokes K, Russell J, Gray L, et al. CD40-CD40 ligand mediates the recruitment of leukocytes and platelets in the inflamed murine colon. Gastroenterology. 2007;132:955-65 pubmed
    Although the CD40-CD40 ligand (CD40L) signaling pathway has been implicated in the pathogenesis of a variety of diseases, including inflammatory bowel disease, the nature of its contribution to intestinal inflammation remains poorly ..
  42. Lu Z, Yuan L, Zhou X, Sotomayor E, Levitsky H, Pardoll D. CD40-independent pathways of T cell help for priming of CD8(+) cytotoxic T lymphocytes. J Exp Med. 2000;191:541-50 pubmed
    ..shown that a dominant pathway of CD4(+) help is via antigen-presenting cell (APC) activation through engagement of CD40 by CD40 ligand on CD4(+) T cells...
  43. Hernandez M, Shen L, Rock K. CD40 on APCs is needed for optimal programming, maintenance, and recall of CD8+ T cell memory even in the absence of CD4+ T cell help. J Immunol. 2008;180:4382-90 pubmed
    b>CD40 stimulation is one of the many signals that can activate APCs and we have recently shown it to have a unique function in generating maximum primary CD8(+) T cell responses...
  44. Zhao Y, Wilson D, Matthews S, Yap G. Rapid elimination of Toxoplasma gondii by gamma interferon-primed mouse macrophages is independent of CD40 signaling. Infect Immun. 2007;75:4799-803 pubmed
    ..b>CD40 ligation has also been shown to trigger autophagic elimination of T...
  45. Hochweller K, Anderton S. Systemic administration of antigen-loaded CD40-deficient dendritic cells mimics soluble antigen administration. Eur J Immunol. 2004;34:990-8 pubmed
    ..We show here that CD40 plays an important rolein this decision...
  46. Xie P, Hostager B, Bishop G. Requirement for TRAF3 in signaling by LMP1 but not CD40 in B lymphocytes. J Exp Med. 2004;199:661-71 pubmed
    b>CD40, a member of the tumor necrosis factor receptor family, and the Epstein-Barr virus-encoded oncoprotein latent membrane protein 1 (LMP1) share several tumor necrosis factor receptor-associated factor (TRAF) adaptor proteins for ..
  47. Calzascia T, Pellegrini M, Lin A, Garza K, Elford A, Shahinian A, et al. CD4 T cells, lymphopenia, and IL-7 in a multistep pathway to autoimmunity. Proc Natl Acad Sci U S A. 2008;105:2999-3004 pubmed publisher
    ..of activated autoreactive CD4 T cells can prime and expand endogenous autoreactive CD8 T cells in a CD28- and CD40-dependent manner through the licensing of dendritic cells. Despite this, mice do not develop diabetes...
  48. Nguyen V, Benveniste E. Involvement of STAT-1 and ets family members in interferon-gamma induction of CD40 transcription in microglia/macrophages. J Biol Chem. 2000;275:23674-84 pubmed
    ..We have previously shown that the cytokine interferon (IFN)-gamma induces CD40 expression in microglia...
  49. Lee B, Haynes L, Eaton S, Swain S, Randall T. The biological outcome of CD40 signaling is dependent on the duration of CD40 ligand expression: reciprocal regulation by interleukin (IL)-4 and IL-12. J Exp Med. 2002;196:693-704 pubmed
    b>CD40 ligand (CD154) expression on activated T cells can be separated into an early TCR-dependent phase, which occurs between 0 and 24 h after activation, and a later extended phase, which occurs after 24 h and is reciprocally regulated by ..
  50. Donners M, Beckers L, Lievens D, Munnix I, Heemskerk J, Janssen B, et al. The CD40-TRAF6 axis is the key regulator of the CD40/CD40L system in neointima formation and arterial remodeling. Blood. 2008;111:4596-604 pubmed publisher
    We investigated the role of CD40 and CD40L in neointima formation and identified the downstream CD40-signaling intermediates (tumor necrosis factor [TNF]-receptor associated factors [TRAF]) involved...
  51. Yasui T, Muraoka M, Takaoka Shichijo Y, Ishida I, Takegahara N, Uchida J, et al. Dissection of B cell differentiation during primary immune responses in mice with altered CD40 signals. Int Immunol. 2002;14:319-29 pubmed
    b>CD40 is essential for efficient humoral immune responses. CD40 has two cytoplasmic domains required for binding of tumor necrosis factor receptor-associated factors (TRAF)...
  52. Moodycliffe A, Shreedhar V, Ullrich S, Walterscheid J, Bucana C, Kripke M, et al. CD40-CD40 ligand interactions in vivo regulate migration of antigen-bearing dendritic cells from the skin to draining lymph nodes. J Exp Med. 2000;191:2011-20 pubmed
    Whereas CD40-CD40 ligand interactions are important for various dendritic cell (DC) functions in vitro, their in vivo relevance is unknown...
  53. Srivastava N, Sudan R, Saha B. CD40-modulated dual-specificity phosphatases MAPK phosphatase (MKP)-1 and MKP-3 reciprocally regulate Leishmania major infection. J Immunol. 2011;186:5863-72 pubmed publisher
    The macrophage-expressed CD40 regulates immune responses to Leishmania major infection by reciprocal signaling through p38 MAPK and ERK1/2. CD40-induced IL-10 or IL-12 plays crucial roles in the promotion or protection from L...