Cd38

Summary

Gene Symbol: Cd38
Description: CD38 antigen
Alias: ADPRC 1, Cd38-rs1, I-19, ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1, 2'-phospho-ADP-ribosyl cyclase, 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase, 2'-phospho-cyclic-ADP-ribose transferase, ADP-ribosyl cyclase 1, NIM-R5 antigen, cADPr hydrolase 1, cyclic ADP-ribose hydrolase 1
Species: mouse
Products:     Cd38

Top Publications

  1. Nishina H, Inageda K, Takahashi K, Hoshino S, Ikeda K, Katada T. Cell surface antigen CD38 identified as ecto-enzyme of NAD glycohydrolase has hyaluronate-binding activity. Biochem Biophys Res Commun. 1994;203:1318-23 pubmed
    ..by retinoic acid in human leukemic HL-60 cells is attributed to the molecule of leukocyte cell surface antigen CD38 (Kontani, K., et al. (1993) J. Biol. Chem. 268, 16895-16898)...
  2. Young G, Choleris E, Lund F, Kirkland J. Decreased cADPR and increased NAD+ in the Cd38-/- mouse. Biochem Biophys Res Commun. 2006;346:188-92 pubmed
    b>CD38 is a type II glycoprotein that catalyzes the formation of cyclic ADP-ribose (cADPR), an intracellular calcium signalling molecule, from nicotinamide adenine dinucleotide (NAD(+))...
  3. Sun L, Iqbal J, Dolgilevich S, Yuen T, Wu X, Moonga B, et al. Disordered osteoclast formation and function in a CD38 (ADP-ribosyl cyclase)-deficient mouse establishes an essential role for CD38 in bone resorption. FASEB J. 2003;17:369-75 pubmed
    We have evaluated the role of the ADP-ribosyl cyclase, CD38, in bone remodeling, a process by which the skeleton is being renewed constantly through the coordinated activity of osteoclasts and osteoblasts...
  4. Thai T, Fellner S, Arendshorst W. ADP-ribosyl cyclase and ryanodine receptor activity contribute to basal renal vasomotor tone and agonist-induced renal vasoconstriction in vivo. Am J Physiol Renal Physiol. 2007;293:F1107-14 pubmed
    ..001). RBF studies in rats were extended to mice lacking the predominant form of ADPR cyclase (CD38)...
  5. Chen J, Chen Y, Reifsnyder P, Schott W, Lee C, Osborne M, et al. Targeted disruption of CD38 accelerates autoimmune diabetes in NOD/Lt mice by enhancing autoimmunity in an ADP-ribosyltransferase 2-dependent fashion. J Immunol. 2006;176:4590-9 pubmed
    Ubiquitously expressed CD38 and T cell-expressed ADP-ribosyltransferase 2 (ART2) are ectoenzymes competing for NAD substrate...
  6. Sandoval Montes C, Santos Argumedo L. CD38 is expressed selectively during the activation of a subset of mature T cells with reduced proliferation but improved potential to produce cytokines. J Leukoc Biol. 2005;77:513-21 pubmed
    b>CD38 is an approximately 45-kDa type II transmembrane glycoprotein expressed by hematopoietic and nonhematopoietic cells...
  7. Hubert S, Rissiek B, Klages K, Huehn J, Sparwasser T, Haag F, et al. Extracellular NAD+ shapes the Foxp3+ regulatory T cell compartment through the ART2-P2X7 pathway. J Exp Med. 2010;207:2561-8 pubmed publisher
    ..Moreover, lower T reg cell numbers are found in mice deficient for the NAD-hydrolase CD38 than in wild-type, P2X7-deficient, or ART2-deficient mice, indicating a role for extracellular NAD(+) in T reg cell ..
  8. Kato I, Yamamoto Y, Fujimura M, Noguchi N, Takasawa S, Okamoto H. CD38 disruption impairs glucose-induced increases in cyclic ADP-ribose, [Ca2+]i, and insulin secretion. J Biol Chem. 1999;274:1869-72 pubmed
    ..has been postulated to serve as a second messenger for intracellular Ca2+ mobilization for insulin secretion, and CD38 is thought to be involved in the cADPR accumulation (Takasawa, S., Tohgo, A., Noguchi, N., Koguma, T., Nata, K...
  9. Jin D, Liu H, Hirai H, Torashima T, Nagai T, Lopatina O, et al. CD38 is critical for social behaviour by regulating oxytocin secretion. Nature. 2007;446:41-5 pubmed
    b>CD38, a transmembrane glycoprotein with ADP-ribosyl cyclase activity, catalyses the formation of Ca2+ signalling molecules, but its role in the neuroendocrine system is unknown...

More Information

Publications83

  1. Cosker F, Cheviron N, Yamasaki M, Menteyne A, Lund F, Moutin M, et al. The ecto-enzyme CD38 is a nicotinic acid adenine dinucleotide phosphate (NAADP) synthase that couples receptor activation to Ca2+ mobilization from lysosomes in pancreatic acinar cells. J Biol Chem. 2010;285:38251-9 pubmed publisher
    ..The ecto-enzyme CD38, involved in many functions as diverse as cell proliferation and social behavior, represents an important ..
  2. Higashida H, Yokoyama S, Kikuchi M, Munesue T. CD38 and its role in oxytocin secretion and social behavior. Horm Behav. 2012;61:351-8 pubmed publisher
    Here, we review the functional roles of cyclic ADP-ribose and CD38, a transmembrane protein with ADP-ribosyl cyclase activity, in mouse social behavior via the regulation of oxytocin (OXT) release, an essential component of social ..
  3. Boini K, Xia M, Xiong J, Li C, Payne L, Li P. Implication of CD38 gene in podocyte epithelial-to-mesenchymal transition and glomerular sclerosis. J Cell Mol Med. 2012;16:1674-85 pubmed publisher
    b>CD38 is a multifunctional protein involving in a number of signalling pathways...
  4. Zhang F, Xia M, Li P. Lysosome-dependent Ca(2+) release response to Fas activation in coronary arterial myocytes through NAADP: evidence from CD38 gene knockouts. Am J Physiol Cell Physiol. 2010;298:C1209-16 pubmed publisher
    ..The hypothesis being tested is that CD38 signaling pathway mediates FasL-induced intracellular Ca(2+) release through nicotinic acid adenine dinucleotide ..
  5. Barbosa M, Soares S, Novak C, Sinclair D, Levine J, Aksoy P, et al. The enzyme CD38 (a NAD glycohydrolase, EC 3.2.2.5) is necessary for the development of diet-induced obesity. FASEB J. 2007;21:3629-39 pubmed
    ..Here, we demonstrate a novel role for protein CD38 as a regulator of body weight during a high-fat diet...
  6. Mayo L, Jacob Hirsch J, Amariglio N, Rechavi G, Moutin M, Lund F, et al. Dual role of CD38 in microglial activation and activation-induced cell death. J Immunol. 2008;181:92-103 pubmed
    ..Using mouse primary microglial cultures, we show that the ectoenzyme CD38, via its calcium-mobilizing metabolite cyclic-ADP-ribose (cADPR), helps promote microglial activation and AICD ..
  7. Cockayne D, Muchamuel T, Grimaldi J, Muller Steffner H, Randall T, Lund F, et al. Mice deficient for the ecto-nicotinamide adenine dinucleotide glycohydrolase CD38 exhibit altered humoral immune responses. Blood. 1998;92:1324-33 pubmed
    b>CD38 is a membrane-associated ecto-nicotinamide adenine dinucleotide (NAD+) glycohydrolase that is expressed on multiple hematopoietic cells...
  8. Takahashi J, Kagaya Y, Kato I, Ohta J, Isoyama S, Miura M, et al. Deficit of CD38/cyclic ADP-ribose is differentially compensated in hearts by gender. Biochem Biophys Res Commun. 2003;312:434-40 pubmed
    To elucidate whether myocardial CD38/cyclic ADP-ribose (cADPR) signaling plays a physiological role, we investigated the heart of CD38 knockout mice (CD38KO)...
  9. Guedes A, Jude J, Paulin J, Kita H, Lund F, Kannan M. Role of CD38 in TNF-alpha-induced airway hyperresponsiveness. Am J Physiol Lung Cell Mol Physiol. 2008;294:L290-9 pubmed
    b>CD38 is involved in normal airway function, IL-13-induced airway hyperresponsiveness (AHR), and is also regulated by tumor necrosis factor (TNF)-alpha in airway smooth muscle (ASM) cells...
  10. Aksoy P, White T, Thompson M, Chini E. Regulation of intracellular levels of NAD: a novel role for CD38. Biochem Biophys Res Commun. 2006;345:1386-92 pubmed
    ..However, to date, the mechanisms that regulate intracellular levels of NAD have not been completely elucidated. CD38 is a multifunctional enzyme ubiquitously distributed in mammalian tissues...
  11. Choe C, Lardong K, Gelderblom M, Ludewig P, Leypoldt F, Koch Nolte F, et al. CD38 exacerbates focal cytokine production, postischemic inflammation and brain injury after focal cerebral ischemia. PLoS ONE. 2011;6:e19046 pubmed publisher
    ..e., macrophages and microglia. The bifunctional receptor and ectoenzyme CD38 synthesizes calcium-mobilizing second messengers (e.g...
  12. Aksoy P, Escande C, White T, Thompson M, Soares S, Benech J, et al. Regulation of SIRT 1 mediated NAD dependent deacetylation: a novel role for the multifunctional enzyme CD38. Biochem Biophys Res Commun. 2006;349:353-9 pubmed
    ..How the endogenous activity of SIRT 1 is modulated is not known. The enzyme CD38 is a multifunctional enzyme capable of synthesis of the second messenger, cADPR, NAADP, and ADPR...
  13. Lund F. Signaling properties of CD38 in the mouse immune system: enzyme-dependent and -independent roles in immunity. Mol Med. 2006;12:328-33 pubmed
    The 5th international CD38 meeting, held in Torino, Italy, spanned a range of topics from the role of CD38 as a signaling receptor in lymphocytic tumors to the importance of CD38-derived metabolites in NAD(+) metabolism, calcium signaling,..
  14. Partida Sanchez S, Cockayne D, Monard S, Jacobson E, Oppenheimer N, Garvy B, et al. Cyclic ADP-ribose production by CD38 regulates intracellular calcium release, extracellular calcium influx and chemotaxis in neutrophils and is required for bacterial clearance in vivo. Nat Med. 2001;7:1209-16 pubmed
    ..b>CD38, the best-characterized mammalian ADP-ribosyl cyclase, is postulated to be an important source of cyclic ADP-ribose ..
  15. Krebs C, Adriouch S, Braasch F, Koestner W, Leiter E, Seman M, et al. CD38 controls ADP-ribosyltransferase-2-catalyzed ADP-ribosylation of T cell surface proteins. J Immunol. 2005;174:3298-305 pubmed
    ..This in turn activates P2X7 and induces exposure of phosphatidylserine and shedding of CD62L. CD38, a potent ecto-NAD-glycohydrolase, is strongly expressed by most B cells but only weakly by T cells...
  16. Thai T, Arendshorst W. Mice lacking the ADP ribosyl cyclase CD38 exhibit attenuated renal vasoconstriction to angiotensin II, endothelin-1, and norepinephrine. Am J Physiol Renal Physiol. 2009;297:F169-76 pubmed publisher
    ..At least two ADPR cyclase family members have been identified in mammals: CD38 and CD157...
  17. Higashida H, Yokoyama S, Huang J, Liu L, Ma W, Akther S, et al. Social memory, amnesia, and autism: brain oxytocin secretion is regulated by NAD+ metabolites and single nucleotide polymorphisms of CD38. Neurochem Int. 2012;61:828-38 pubmed publisher
    Previously, we demonstrated that CD38, a transmembrane protein with ADP-ribosyl cyclase activity, plays a critical role in mouse social behavior by regulating the release of oxytocin (OXT), which is essential for mutual recognition...
  18. Partida Sanchez S, Goodrich S, Kusser K, Oppenheimer N, Randall T, Lund F. Regulation of dendritic cell trafficking by the ADP-ribosyl cyclase CD38: impact on the development of humoral immunity. Immunity. 2004;20:279-91 pubmed
    Mice lacking CD38, an ectoenzyme that generates the calcium-mobilizing metabolite cADPR, make reduced T cell-dependent antibody responses...
  19. Adriouch S, Hubert S, Pechberty S, Koch Nolte F, Haag F, Seman M. NAD+ released during inflammation participates in T cell homeostasis by inducing ART2-mediated death of naive T cells in vivo. J Immunol. 2007;179:186-94 pubmed
    ..This leads to T cell depletion in the draining lymph nodes from wild-type and, more severely, from mice lacking the CD38 NAD(+) glycohydrolase, whereas no effect is observed in ART2-deficient animals...
  20. Partida Sanchez S, Rivero Nava L, Shi G, Lund F. CD38: an ecto-enzyme at the crossroads of innate and adaptive immune responses. Adv Exp Med Biol. 2007;590:171-83 pubmed
  21. Xu M, Zhang Y, Xia M, Li X, Ritter J, Zhang F, et al. NAD(P)H oxidase-dependent intracellular and extracellular O2•- production in coronary arterial myocytes from CD38 knockout mice. Free Radic Biol Med. 2012;52:357-65 pubmed publisher
    ..However, it remains unknown how the activity of NAD(P)H oxidase is regulated in arterial myocytes. Recently, CD38-associated ADP-ribosylcyclase has been reported to use an NAD(P)H oxidase product, NAD(+) or NADP(+), to produce ..
  22. Rodríguez Alba J, Moreno Garcia M, Sandoval Montes C, Rosales Garcia V, Santos Argumedo L. CD38 induces differentiation of immature transitional 2 B lymphocytes in the spleen. Blood. 2008;111:3644-52 pubmed publisher
    b>CD38 is a surface receptor able to induce activation, proliferation, and survival of human and mouse lymphocytes; this molecule is expressed on the surface of both mature and immature B cells...
  23. Chen Y, Chen J, Osborne M, Chapman H, Besra G, Porcelli S, et al. CD38 is required for the peripheral survival of immunotolerogenic CD4+ invariant NK T cells in nonobese diabetic mice. J Immunol. 2006;177:2939-47 pubmed
    ..Conversely, T1D is accelerated in NOD mice lacking CD38 molecules that play a role in dendritic cell migration to inflamed tissues...
  24. Kim S, Cho B, Kim U. CD38-mediated Ca2+ signaling contributes to angiotensin II-induced activation of hepatic stellate cells: attenuation of hepatic fibrosis by CD38 ablation. J Biol Chem. 2010;285:576-82 pubmed publisher
    b>CD38 is a type II glycoprotein that is responsible for the synthesis and hydrolysis of cyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP), Ca(2+)-mobilizing second messengers...
  25. Young L. Regulating the social brain: a new role for CD38. Neuron. 2007;54:353-6 pubmed
    ..A recent paper by Jin et al. published in Nature demonstrates that the transmembrane receptor CD38 plays a critical role in regulating social behaviors by regulating the release of OT from hypothalamic neurons.
  26. Durnin L, Mutafova Yambolieva V. Cyclic ADP-ribose requires CD38 to regulate the release of ATP in visceral smooth muscle. FEBS J. 2011;278:3095-108 pubmed publisher
    ..b>CD38 is a multifunctional enzyme involved in the formation of cADPR in mammals...
  27. Iqbal J, Zaidi M. CD38 is required for priming by TNF-alpha: a mechanism for extracellular coordination of cell fate. Am J Physiol Renal Physiol. 2007;292:F1283-90 pubmed
    ..it is shown that the cytokine TNF-alpha is capable of affecting the fate of macrophages by upregulating the NADase CD38. CD38 upregulation primes macrophages, such that signals induced by inflammatory stimuli are augmented, while those ..
  28. Iqbal J, Kumar K, Sun L, Zaidi M. Selective upregulation of the ADP-ribosyl cyclases CD38 and CD157 by TNF but not by RANK-L reveals differences in downstream signaling. Am J Physiol Renal Physiol. 2006;291:F557-66 pubmed
    ..TNF but not RANK-L led to the sustained upregulation of both CD38 and CD157 as demonstrated by real-time PCR and flow cytometry...
  29. Akther S, Korshnova N, Zhong J, Liang M, Cherepanov S, Lopatina O, et al. CD38 in the nucleus accumbens and oxytocin are related to paternal behavior in mice. Mol Brain. 2013;6:41 pubmed publisher
    ..The neural circuitry and hormones that control paternal behavior are not well-understood. CD38, a membrane glycoprotein, catalyzes synthesis of cyclic ADP-ribose and facilitates oxytocin (OT) secretion due to ..
  30. Levy A, Blacher E, Vaknine H, Lund F, Stein R, Mayo L. CD38 deficiency in the tumor microenvironment attenuates glioma progression and modulates features of tumor-associated microglia/macrophages. Neuro Oncol. 2012;14:1037-49 pubmed publisher
    ..There is increasing evidence that the tumor-associated MM support glioma expansion. CD38 is a multifunctional ectoenzyme that uses nicotinamide adenine dinucleotide as a substrate to generate second ..
  31. Romero Ramirez H, Morales Guadarrama M, Pelayo R, López Santiago R, Santos Argumedo L. CD38 expression in early B-cell precursors contributes to extracellular signal-regulated kinase-mediated apoptosis. Immunology. 2015;144:271-81 pubmed publisher
    b>CD38 is a 45,000 molecular weight transmembrane protein that is expressed in immature and mature lymphocytes. However, the expression and function of CD38 during B-cell differentiation in mice is poorly understood...
  32. Mitsui Saito M, Kato I, Takasawa S, Okamoto H, Yanagisawa T. CD38 gene disruption inhibits the contraction induced by alpha-adrenoceptor stimulation in mouse aorta. J Vet Med Sci. 2003;65:1325-30 pubmed
    b>CD38 is an ectoenzyme with ADP-ribosyl cyclase and hydrolase activities, which synthesizes cyclic ADP-ribose from NAD and hydrolyzes cyclic ADP-ribose to ADP-ribose...
  33. Bergthorsdottir S, Gallagher A, Jainandunsing S, Cockayne D, Sutton J, Leanderson T, et al. Signals that initiate somatic hypermutation of B cells in vitro. J Immunol. 2001;166:2228-34 pubmed
    ..three signals are required to allow detection of somatic mutation in vitro; these are anti-Ig, anti-CD40, and anti-CD38. If any one of these is omitted, mutation remains off...
  34. Ma Y, Cao W, Wang L, Jiang J, Nie H, Wang B, et al. Basal CD38/cyclic ADP-ribose-dependent signaling mediates ATP release and survival of microglia by modulating connexin 43 hemichannels. Glia. 2014;62:943-55 pubmed publisher
    ..b>CD38 is an ectoenzyme that consumes NAD(+) to produce cyclic ADP-ribose (cADPR), a potent agonist of ryanodine receptors...
  35. Xu X, Yuan X, Li N, Dewey W, Li P, Zhang F. Lysosomal cholesterol accumulation in macrophages leading to coronary atherosclerosis in CD38(-/-) mice. J Cell Mol Med. 2016;20:1001-13 pubmed publisher
    ..that lysosomal Ca(2+) messenger of nicotinic acid adenine dinucleotide phosphate (NAADP), an enzymatic product of CD38 ADP-ribosylcyclase (CD38), promoted lipid endocytic trafficking in human fibroblast cells...
  36. Guan X, Liu X, Hong X, Zhao N, Xiao Y, Wang L, et al. CD38 Deficiency Protects the Heart from Ischemia/Reperfusion Injury through Activating SIRT1/FOXOs-Mediated Antioxidative Stress Pathway. Oxid Med Cell Longev. 2016;2016:7410257 pubmed publisher
    ..We previously observed that CD38 deficiency remarkably protects mouse embryonic fibroblasts (MEFs) from oxidative stress-induced injury...
  37. Santos Argumedo L, Lund F, Heath A, Solvason N, Wu W, Grimaldi J, et al. CD38 unresponsiveness of xid B cells implicates Bruton's tyrosine kinase (btk) as a regular of CD38 induced signal transduction. Int Immunol. 1995;7:163-70 pubmed
    b>CD38 is a 42 kDa membrane-associated ectoenzyme expressed by a large proportion of human and mouse lymphocytes...
  38. Chatterjee S, Daenthanasanmak A, Chakraborty P, Wyatt M, Dhar P, Selvam S, et al. CD38-NAD+Axis Regulates Immunotherapeutic Anti-Tumor T Cell Response. Cell Metab. 2018;27:85-100.e8 pubmed publisher
    ..Importantly, T cells with reduced surface expression of the NADase CD38 exhibited intrinsically higher NAD+, enhanced oxidative phosphorylation, higher glutaminolysis, and ..
  39. Schenten D, Egert A, Pasparakis M, Rajewsky K. M17, a gene specific for germinal center (GC) B cells and a prognostic marker for GC B-cell lymphomas, is dispensable for the GC reaction in mice. Blood. 2006;107:4849-56 pubmed
    ..Thus, M17 is dispensable for the GC reaction, and its potential function in the pathogenesis of DLBCL remains elusive. ..
  40. Vaisitti T, Aydin S, Rossi D, Cottino F, Bergui L, D Arena G, et al. CD38 increases CXCL12-mediated signals and homing of chronic lymphocytic leukemia cells. Leukemia. 2010;24:958-69 pubmed publisher
    ..0002). CD38 expression was the parameter most strongly associated with heightened CXCL12 signaling (P<0...
  41. Gally F, Hartney J, Janssen W, Perraud A. CD38 plays a dual role in allergen-induced airway hyperresponsiveness. Am J Respir Cell Mol Biol. 2009;40:433-42 pubmed publisher
    The multifunctional surface protein CD38 acts as a receptor with ecto-enzymatic activity, hydrolyzing NAD to generate several products known to exhibit Ca2+-mobilizing properties...
  42. Thai T, Arendshorst W. ADP-ribosyl cyclase and ryanodine receptors mediate endothelin ETA and ETB receptor-induced renal vasoconstriction in vivo. Am J Physiol Renal Physiol. 2008;295:F360-8 pubmed publisher
    ..04 for both) in Sprague-Dawley rats. Mice lacking the predominant form of ADPR cyclase (CD38-/-) had RBF responses to ET-1 that were 47% weaker than those seen in wild-type mice (P = 0.01)...
  43. Mihara K, Yanagihara K, Takigahira M, Imai C, Kitanaka A, Takihara Y, et al. Activated T-cell-mediated immunotherapy with a chimeric receptor against CD38 in B-cell non-Hodgkin lymphoma. J Immunother. 2009;32:737-43 pubmed publisher
    ..b>CD38, highly expressed in B-cell non-Hodgkin lymphoma (B-NHL) cells, is an attractive target in immunotherapy for B-NHL...
  44. Thompson M, Barata da Silva H, Zielinska W, White T, Bailey J, Lund F, et al. Role of CD38 in myometrial Ca2+ transients: modulation by progesterone. Am J Physiol Endocrinol Metab. 2004;287:E1142-8 pubmed
    ..Here, using a knockout model, we found that the enzyme CD38, responsible for the synthesis of the second messenger cyclic ADP-ribose (cADPR), plays an important role in the ..
  45. Bao J, Zhang Q, Wang M, Xia M, Boini K, Gulbins E, et al. Implication of CD38 gene in autophagic degradation of collagen I in mouse coronary arterial myocytes. Front Biosci (Landmark Ed). 2017;22:558-569 pubmed
    ..Thus, we determined the role of CD38, an enzyme involved in cellular calcium modulation and autophagic flux, in the regulation of collagen I degradation ..
  46. Jain D, Keslacy S, Tliba O, Cao Y, Kierstein S, Amin K, et al. Essential role of IFNbeta and CD38 in TNFalpha-induced airway smooth muscle hyper-responsiveness. Immunobiology. 2008;213:499-509 pubmed publisher
    ..necrosis factor (TNF)alpha-induced expression of inflammatory genes in airway smooth muscle (ASM) cells, including CD38, known to regulate calcium signaling...
  47. Rah S, Kim U. CD38-mediated Ca(2+) signaling contributes to glucagon-induced hepatic gluconeogenesis. Sci Rep. 2015;5:10741 pubmed publisher
    b>CD38 is a multifunctional enzyme for the synthesis of Ca(2+) second messengers. Glucagon promotes hepatic glucose production through Ca(2+) signaling in the fasting condition...
  48. Shawl A, Park K, Kim U. Insulin receptor signaling for the proliferation of pancreatic ?-cells: involvement of Ca2+ second messengers, IP3, NAADP and cADPR. Islets. 2009;1:216-23 pubmed publisher
    ..Herein, we show the insulin receptor signaling pathway underlying CD38/ADPR-cyclase activation for NAADP/cADPR formation to induce Ca2+ rise, ultimately resulting in ?-cell proliferation...
  49. Ma Y, Jiang J, Wang L, Nie H, Xia W, Liu J, et al. CD38 is a key enzyme for the survival of mouse microglial BV2 cells. Biochem Biophys Res Commun. 2012;418:714-9 pubmed publisher
    b>CD38 is a multifunctional enzyme that can not only generate cyclic adenosine diphosphate-ribose (cADPR) - a key Ca(2+) -mobilizing second messenger - by consuming NAD(+), but also hydrolyze extracellular NAD(+)...
  50. Moreno Garcia M, Partida Sanchez S, Primack J, Sumoza Toledo A, Muller Steffner H, Schuber F, et al. CD38 is expressed as noncovalently associated homodimers on the surface of murine B lymphocytes. Eur J Biochem. 2004;271:1025-34 pubmed
    b>CD38 is a transmembrane glycoprotein that functions as an ectoenzyme and as a receptor...
  51. Rah S, Mushtaq M, Nam T, Kim S, Kim U. Generation of cyclic ADP-ribose and nicotinic acid adenine dinucleotide phosphate by CD38 for Ca2+ signaling in interleukin-8-treated lymphokine-activated killer cells. J Biol Chem. 2010;285:21877-87 pubmed publisher
    ..In this study we examined the possibility that IL-8 activates CD38 to produce another messenger, nicotinic acid adenine dinucleotide phosphate (NAADP), in LAK cells, and we showed ..
  52. Blacher E, Dadali T, Bespalko A, Haupenthal V, Grimm M, Hartmann T, et al. Alzheimer's disease pathology is attenuated in a CD38-deficient mouse model. Ann Neurol. 2015;78:88-103 pubmed publisher
    ..The nicotinamide adenine dinucleotide (NAD) glycohydrolase CD38, which is expressed by neurons, astrocytes, and microglial cells, regulates inflammatory and repair processes in ..
  53. Cho Y, Han M, Choi Y, Yun Y, Shin J, Kim U. Direct interaction of the CD38 cytoplasmic tail and the Lck SH2 domain. Cd38 transduces T cell activation signals through associated Lck. J Biol Chem. 2000;275:1685-90 pubmed
    b>CD38 ligation has been shown to induce activation of intracellular signaling cascade in T lymphocytes through a Lck-dependent pathway. However, it is not clear how Lck initiates the CD38-mediated signaling process...
  54. Dewitt S, Laffafian I, Hallett M. Does neutrophil CD38 have a role in Ca++ signaling triggered by beta2 integrin?. Nat Med. 2002;8:307; author reply 307-8 pubmed
  55. Lischke T, Schumacher V, Wesolowski J, Hurwitz R, Haag F, Koch Nolte F, et al. CD8-? ADP-ribosylation affects CD8(+) T-cell function. Eur J Immunol. 2013;43:1828-38 pubmed publisher
    ..ADP-ribosylation of CD8-? occurred during cell isolation, particularly when cells were isolated from CD38-deficient mice...
  56. Wei W, Sun H, Ting K, Zhang L, Lee H, Li G, et al. Inhibition of cardiomyocytes differentiation of mouse embryonic stem cells by CD38/cADPR/Ca2+ signaling pathway. J Biol Chem. 2012;287:35599-611 pubmed publisher
    ..The main ADP-ribosyl cyclase in mammals is CD38, a multi-functional enzyme and a type II membrane protein...
  57. Guan X, Hong X, Zhao N, Liu X, Xiao Y, Chen T, et al. CD38 promotes angiotensin II-induced cardiac hypertrophy. J Cell Mol Med. 2017;21:1492-1502 pubmed publisher
    ..Recently, we observed that mouse embryonic fibroblasts from CD38 knockout mice were significantly resistant to oxidative stress such as H2 O2 -induced injury ..
  58. Deshpande D, White T, Guedes A, Milla C, Walseth T, Lund F, et al. Altered airway responsiveness in CD38-deficient mice. Am J Respir Cell Mol Biol. 2005;32:149-56 pubmed
    ..In this study we determined the functional role of CD38/cADPR signaling in the regulation of airway tone using CD38 deficient (cd38(-/-)) mice...
  59. Yasue T, Nishizumi H, Aizawa S, Yamamoto T, Miyake K, Mizoguchi C, et al. A critical role of Lyn and Fyn for B cell responses to CD38 ligation and interleukin 5. Proc Natl Acad Sci U S A. 1997;94:10307-12 pubmed
    b>CD38 ligation on mouse B cells by CS/2, an anti-mouse CD38 mAb, induced proliferation, interleukin 5 (IL-5) receptor alpha chain expression, and tyrosine phosphorylation of Bruton tyrosine kinase (Btk) from wild-type, but not from X ..
  60. Blacher E, Ben Baruch B, Levy A, Geva N, Green K, Garneau Tsodikova S, et al. Inhibition of glioma progression by a newly discovered CD38 inhibitor. Int J Cancer. 2015;136:1422-33 pubmed publisher
    ..Recently, using a syngeneic mouse glioma progression model, we showed that the ectoenzyme CD38 regulated microglia activation and, in addition, that the loss of CD38 from the tumor microenvironment attenuated ..
  61. Manjarrez Orduno N, Moreno Garcia M, Fink K, Santos Argumedo L. CD38 cross-linking enhances TLR-induced B cell proliferation but decreases IgM plasma cell differentiation. Eur J Immunol. 2007;37:358-67 pubmed
    ..The cross-linking of the surface molecule CD38 induces calcium mobilization, protein phosphorylation and NF-kappaB translocation into the nucleus, ultimately ..
  62. Wu Y, Liang L, Shi G. [CD38 protein reduces LPS/D-galactosamine-induced acute damage of liver tissues via down-regulating inflammatory cytokine expressions]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2014;30:1009-12 pubmed
    To investigate the role of CD38 in lipopolysaccharide (LPS)/D-galactosamine (D-GalN)-induced acute hepatic injury in mice and explore the potential mechanism...
  63. Liu S, Madiai F, Hackshaw K, Allen C, Carl J, Huschart E, et al. The large zinc finger protein ZAS3 is a critical modulator of osteoclastogenesis. PLoS ONE. 2011;6:e17161 pubmed publisher
  64. Harada N, Santos Argumedo L, Chang R, Grimaldi J, Lund F, Brannan C, et al. Expression cloning of a cDNA encoding a novel murine B cell activation marker. Homology to human CD38. J Immunol. 1993;151:3111-8 pubmed
    ..and deduced amino acid sequence show approximately 70% homology to the previously reported sequence of human CD38, suggesting that I-19 cDNA encodes either the mouse homologue of CD38 or a closely related protein...
  65. Schmid F, Bruhn S, Weber K, Mittrücker H, Guse A. CD38: a NAADP degrading enzyme. FEBS Lett. 2011;585:3544-8 pubmed publisher
    The role of the multifunctional enzyme CD38 in formation of the Ca(2+)-mobilizing second messenger nicotinic acid adenine dinucleotide phosphate (NAADP) was investigated...
  66. Zhang Y, Xu M, Xia M, Li X, Boini K, Wang M, et al. Defective autophagosome trafficking contributes to impaired autophagic flux in coronary arterial myocytes lacking CD38 gene. Cardiovasc Res. 2014;102:68-78 pubmed publisher
    ..Here, we revealed a previously undefined role of CD38, an enzyme that metabolizes NADP(+) into NAADP, in the regulation of autophagic flux in coronary arterial myocytes (..
  67. Guedes A, Paulin J, Rivero Nava L, Kita H, Lund F, Kannan M. CD38-deficient mice have reduced airway hyperresponsiveness following IL-13 challenge. Am J Physiol Lung Cell Mol Physiol. 2006;291:L1286-93 pubmed
    The transmembrane glycoprotein CD38 in airway smooth muscle is the source of cyclic-ADP ribose, an intracellular calcium-releasing molecule, and is subject to regulatory effects of cytokines such as interleukin (IL)-13, a cytokine ..
  68. Wei W, Lu Y, Hao B, Zhang K, Wang Q, Miller A, et al. CD38 Is Required for Neural Differentiation of Mouse Embryonic Stem Cells by Modulating Reactive Oxygen Species. Stem Cells. 2015;33:2664-73 pubmed publisher
    b>CD38 is a multifunctional membrane enzyme and the main mammalian ADP-ribosyl cyclase, which catalyzes the synthesis and hydrolysis of cADPR, a potent endogenous Ca(2+) mobilizing messenger...
  69. Karakasheva T, Waldron T, Eruslanov E, Kim S, Lee J, O Brien S, et al. CD38-Expressing Myeloid-Derived Suppressor Cells Promote Tumor Growth in a Murine Model of Esophageal Cancer. Cancer Res. 2015;75:4074-85 pubmed publisher
    ..conditional p120-catenin knockout mice (L2-cre;p120ctn(f/f)), a model of oral-esophageal cancer, we have identified CD38 as playing a vital role in MDSC biology, previously unknown...
  70. Ceni C, Pochon N, Villaz M, Muller Steffner H, Schuber F, Baratier J, et al. The CD38-independent ADP-ribosyl cyclase from mouse brain synaptosomes: a comparative study of neonate and adult brain. Biochem J. 2006;395:417-26 pubmed
    ..We also demonstrate, by comparing wild-type and Cd38-/- tissues, that brain cADPR content is independent of the presence of CD38 (the best characterized mammalian ADP-..
  71. Oliver A, Martin F, Kearney J. Mouse CD38 is down-regulated on germinal center B cells and mature plasma cells. J Immunol. 1997;158:1108-15 pubmed
    ..Human CD38 is highly expressed on both germinal center B cells and plasma cells, and is useful in delineating these B cell ..
  72. Guedes A, Rudé E, Kannan M. Potential role of the CD38/cADPR signaling pathway as an underlying mechanism of the effects of medetomidine on insulin and glucose homeostasis. Vet Anaesth Analg. 2013;40:512-6 pubmed publisher
    To investigate the CD38/cADPR signaling pathway as possible underlying mechanism of the effects of medetomidine on insulin and glucose homeostasis. Thirty-two C57BL/6 mice of both sexes...
  73. Reyes L, Boslett J, Varadharaj S, De Pascali F, Hemann C, Druhan L, et al. Depletion of NADP(H) due to CD38 activation triggers endothelial dysfunction in the postischemic heart. Proc Natl Acad Sci U S A. 2015;112:11648-53 pubmed publisher
    ..Profound endothelial NADPH depletion was identified to be due to marked activation of the NAD(P)ase-activity of CD38 and could be prevented by inhibition or specific knockdown of this protein...
  74. Orabi A, Muili K, Javed T, Jin S, Jayaraman T, Lund F, et al. Cluster of differentiation 38 (CD38) mediates bile acid-induced acinar cell injury and pancreatitis through cyclic ADP-ribose and intracellular calcium release. J Biol Chem. 2013;288:27128-37 pubmed publisher
    ..the nucleotide second messenger cyclic ADP-ribose (cADPR), which is generated by an ectoenzyme ADP-ribosyl cyclase, CD38. In this study, we examined the role of CD38 and cADPR in acinar cell Ca(2+) signals and acinar injury due to bile ..