Cd36

Summary

Gene Symbol: Cd36
Description: CD36 molecule
Alias: FAT, GPIV, Scarb3, platelet glycoprotein 4, CD36 antigen, GPIIIB, PAS IV, PAS-4, fatty acid translocase, glycoprotein IIIb, platelet glycoprotein IV
Species: mouse
Products:     Cd36

Top Publications

  1. Fonager J, Pasini E, Braks J, Klop O, Ramesar J, Remarque E, et al. Reduced CD36-dependent tissue sequestration of Plasmodium-infected erythrocytes is detrimental to malaria parasite growth in vivo. J Exp Med. 2012;209:93-107 pubmed publisher
    ..falciparum by adhering to the host receptor CD36. To experimentally determine the significance of sequestration for parasite growth, we generated a mutant P...
  2. Court N, Vasseur V, Vacher R, Fremond C, Shebzukhov Y, Yeremeev V, et al. Partial redundancy of the pattern recognition receptors, scavenger receptors, and C-type lectins for the long-term control of Mycobacterium tuberculosis infection. J Immunol. 2010;184:7057-70 pubmed publisher
    ..We show that a single deficiency in the class A SR, macrophage receptor with collagenous structure, CD36, mannose receptor, specific ICAM-3 grabbing nonintegrin-related, or F4/80 did not impair the host resistance to ..
  3. Nahle Z, Hsieh M, Pietka T, Coburn C, Grimaldi P, Zhang M, et al. CD36-dependent regulation of muscle FoxO1 and PDK4 in the PPAR delta/beta-mediated adaptation to metabolic stress. J Biol Chem. 2008;283:14317-26 pubmed publisher
    ..Previously, we reported that FoxO1 activation in C(2)C(12) muscle cells recruits the fatty acid translocase CD36 to the plasma membrane and increases fatty acid uptake and oxidation...
  4. Patel S, Lu Z, Ayi K, Serghides L, Gowda D, Kain K. Disruption of CD36 impairs cytokine response to Plasmodium falciparum glycosylphosphatidylinositol and confers susceptibility to severe and fatal malaria in vivo. J Immunol. 2007;178:3954-61 pubmed
    b>CD36 is a scavenger receptor that has been implicated in malaria pathogenesis as well as innate defense against blood-stage infection...
  5. Nassir F, Wilson B, Han X, Gross R, Abumrad N. CD36 is important for fatty acid and cholesterol uptake by the proximal but not distal intestine. J Biol Chem. 2007;282:19493-501 pubmed
    b>CD36, a membrane protein that facilitates fatty acid uptake, is highly expressed in the intestine on the luminal surface of enterocytes...
  6. Goudriaan J, den Boer M, Rensen P, Febbraio M, Kuipers F, Romijn J, et al. CD36 deficiency in mice impairs lipoprotein lipase-mediated triglyceride clearance. J Lipid Res. 2005;46:2175-81 pubmed
    b>CD36 is involved in high-affinity peripheral FFA uptake. CD36-deficient (cd36(-)(/)(-)) mice exhibit increased plasma FFA and triglyceride (TG) levels...
  7. Glezer I, Bittencourt J, Rivest S. Neuronal expression of Cd36, Cd44, and Cd83 antigen transcripts maps to distinct and specific murine brain circuits. J Comp Neurol. 2009;517:906-24 pubmed publisher
    ..Surprisingly, we verified that the genes that encode Cd36 and Cd83 are constitutively expressed in specific neuronal cells...
  8. Jimenez Dalmaroni M, Xiao N, Corper A, Verdino P, Ainge G, Larsen D, et al. Soluble CD36 ectodomain binds negatively charged diacylglycerol ligands and acts as a co-receptor for TLR2. PLoS ONE. 2009;4:e7411 pubmed publisher
    Cluster of differentiation 36 (CD36) is a transmembrane glycoprotein involved in many biological processes, such as platelet biology, angiogenesis and in the aetiopathology of atherosclerosis and cardiovascular diseases...
  9. Nauli A, Nassir F, Zheng S, Yang Q, Lo C, Vonlehmden S, et al. CD36 is important for chylomicron formation and secretion and may mediate cholesterol uptake in the proximal intestine. Gastroenterology. 2006;131:1197-207 pubmed
    Studies are aimed to determine the role of CD36 in intestinal lipid absorption. Knock-out (KO) and wild-type (WT) lymph fistula mice were used to study fatty acids (FA) and cholesterol uptake, and chylomicron formation and secretion...
  10. Hale J, Li M, Sinyuk M, Jahnen Dechent W, LATHIA J, Silverstein R. Context dependent role of the CD36--thrombospondin--histidine-rich glycoprotein axis in tumor angiogenesis and growth. PLoS ONE. 2012;7:e40033 pubmed publisher
    ..our laboratory and others has described an important endogenous anti-angiogenic pathway mediated by interactions of CD36, a receptor on microvascular endothelial cells, with proteins containing thrombospondin (TSP) type I repeat domains ..

Detail Information

Publications79

  1. Fonager J, Pasini E, Braks J, Klop O, Ramesar J, Remarque E, et al. Reduced CD36-dependent tissue sequestration of Plasmodium-infected erythrocytes is detrimental to malaria parasite growth in vivo. J Exp Med. 2012;209:93-107 pubmed publisher
    ..falciparum by adhering to the host receptor CD36. To experimentally determine the significance of sequestration for parasite growth, we generated a mutant P...
  2. Court N, Vasseur V, Vacher R, Fremond C, Shebzukhov Y, Yeremeev V, et al. Partial redundancy of the pattern recognition receptors, scavenger receptors, and C-type lectins for the long-term control of Mycobacterium tuberculosis infection. J Immunol. 2010;184:7057-70 pubmed publisher
    ..We show that a single deficiency in the class A SR, macrophage receptor with collagenous structure, CD36, mannose receptor, specific ICAM-3 grabbing nonintegrin-related, or F4/80 did not impair the host resistance to ..
  3. Nahle Z, Hsieh M, Pietka T, Coburn C, Grimaldi P, Zhang M, et al. CD36-dependent regulation of muscle FoxO1 and PDK4 in the PPAR delta/beta-mediated adaptation to metabolic stress. J Biol Chem. 2008;283:14317-26 pubmed publisher
    ..Previously, we reported that FoxO1 activation in C(2)C(12) muscle cells recruits the fatty acid translocase CD36 to the plasma membrane and increases fatty acid uptake and oxidation...
  4. Patel S, Lu Z, Ayi K, Serghides L, Gowda D, Kain K. Disruption of CD36 impairs cytokine response to Plasmodium falciparum glycosylphosphatidylinositol and confers susceptibility to severe and fatal malaria in vivo. J Immunol. 2007;178:3954-61 pubmed
    b>CD36 is a scavenger receptor that has been implicated in malaria pathogenesis as well as innate defense against blood-stage infection...
  5. Nassir F, Wilson B, Han X, Gross R, Abumrad N. CD36 is important for fatty acid and cholesterol uptake by the proximal but not distal intestine. J Biol Chem. 2007;282:19493-501 pubmed
    b>CD36, a membrane protein that facilitates fatty acid uptake, is highly expressed in the intestine on the luminal surface of enterocytes...
  6. Goudriaan J, den Boer M, Rensen P, Febbraio M, Kuipers F, Romijn J, et al. CD36 deficiency in mice impairs lipoprotein lipase-mediated triglyceride clearance. J Lipid Res. 2005;46:2175-81 pubmed
    b>CD36 is involved in high-affinity peripheral FFA uptake. CD36-deficient (cd36(-)(/)(-)) mice exhibit increased plasma FFA and triglyceride (TG) levels...
  7. Glezer I, Bittencourt J, Rivest S. Neuronal expression of Cd36, Cd44, and Cd83 antigen transcripts maps to distinct and specific murine brain circuits. J Comp Neurol. 2009;517:906-24 pubmed publisher
    ..Surprisingly, we verified that the genes that encode Cd36 and Cd83 are constitutively expressed in specific neuronal cells...
  8. Jimenez Dalmaroni M, Xiao N, Corper A, Verdino P, Ainge G, Larsen D, et al. Soluble CD36 ectodomain binds negatively charged diacylglycerol ligands and acts as a co-receptor for TLR2. PLoS ONE. 2009;4:e7411 pubmed publisher
    Cluster of differentiation 36 (CD36) is a transmembrane glycoprotein involved in many biological processes, such as platelet biology, angiogenesis and in the aetiopathology of atherosclerosis and cardiovascular diseases...
  9. Nauli A, Nassir F, Zheng S, Yang Q, Lo C, Vonlehmden S, et al. CD36 is important for chylomicron formation and secretion and may mediate cholesterol uptake in the proximal intestine. Gastroenterology. 2006;131:1197-207 pubmed
    Studies are aimed to determine the role of CD36 in intestinal lipid absorption. Knock-out (KO) and wild-type (WT) lymph fistula mice were used to study fatty acids (FA) and cholesterol uptake, and chylomicron formation and secretion...
  10. Hale J, Li M, Sinyuk M, Jahnen Dechent W, LATHIA J, Silverstein R. Context dependent role of the CD36--thrombospondin--histidine-rich glycoprotein axis in tumor angiogenesis and growth. PLoS ONE. 2012;7:e40033 pubmed publisher
    ..our laboratory and others has described an important endogenous anti-angiogenic pathway mediated by interactions of CD36, a receptor on microvascular endothelial cells, with proteins containing thrombospondin (TSP) type I repeat domains ..
  11. Febbraio M, Podrez E, Smith J, Hajjar D, Hazen S, Hoff H, et al. Targeted disruption of the class B scavenger receptor CD36 protects against atherosclerotic lesion development in mice. J Clin Invest. 2000;105:1049-56 pubmed
    ..To assess the role of the class B scavenger receptor CD36 in atherogenesis, we crossed a CD36-null strain with the atherogenic apo E-null strain and quantified lesion ..
  12. Tran T, Poirier H, Clément L, Nassir F, Pelsers M, Petit V, et al. Luminal lipid regulates CD36 levels and downstream signaling to stimulate chylomicron synthesis. J Biol Chem. 2011;286:25201-10 pubmed publisher
    The membrane glycoprotein CD36 binds nanomolar concentrations of long chain fatty acids (LCFA) and is highly expressed on the luminal surface of enterocytes. CD36 deficiency reduces chylomicron production through unknown mechanisms...
  13. Smith T, Serghides L, Patel S, Febbraio M, Silverstein R, Kain K. CD36-mediated nonopsonic phagocytosis of erythrocytes infected with stage I and IIA gametocytes of Plasmodium falciparum. Infect Immun. 2003;71:393-400 pubmed
    ..Using a number of experimental strategies, we found that the scavenger receptor CD36 mediates the uptake of nonopsonized erythrocytes infected with stage I and IIA gametocytes of Plasmodium falciparum ..
  14. Moore K, El Khoury J, Medeiros L, Terada K, Geula C, Luster A, et al. A CD36-initiated signaling cascade mediates inflammatory effects of beta-amyloid. J Biol Chem. 2002;277:47373-9 pubmed
    ..The class B scavenger receptor, CD36, mediates binding of fibrillar beta-amyloid to cells of the monocyte/macrophage lineage, including brain ..
  15. Greenberg M, Sun M, Zhang R, Febbraio M, Silverstein R, Hazen S. Oxidized phosphatidylserine-CD36 interactions play an essential role in macrophage-dependent phagocytosis of apoptotic cells. J Exp Med. 2006;203:2613-25 pubmed
    ..We show that the class B scavenger receptor CD36 plays an essential role in macrophage clearance of apoptotic cells in vivo...
  16. Bieghs V, Verheyen F, van Gorp P, Hendrikx T, Wouters K, Lutjohann D, et al. Internalization of modified lipids by CD36 and SR-A leads to hepatic inflammation and lysosomal cholesterol storage in Kupffer cells. PLoS ONE. 2012;7:e34378 pubmed publisher
    ..Recently, we demonstrated that combined deletion of the two main scavenger receptors, CD36 and macrophage scavenger receptor 1 (MSR1), which are important for modified cholesterol-rich lipoprotein uptake, ..
  17. Mäkinen P, Lappalainen J, Heinonen S, Leppänen P, Lähteenvuo M, Aarnio J, et al. Silencing of either SR-A or CD36 reduces atherosclerosis in hyperlipidaemic mice and reveals reciprocal upregulation of these receptors. Cardiovasc Res. 2010;88:530-8 pubmed publisher
    Macrophage scavenger receptor A (SR-A) and class B scavenger receptor CD36 (CD36) contribute to foam cell formation and atherogenesis via uptake of modified lipoproteins...
  18. Guest C, Hartman M, O Connor J, Chakour K, Sovari A, Freund G. Phagocytosis of cholesteryl ester is amplified in diabetic mouse macrophages and is largely mediated by CD36 and SR-A. PLoS ONE. 2007;2:e511 pubmed
    ..However, IP administration of CD36 and SR-A blocking antibodies led to 37% and 25% reductions in cholesteryl ester accumulation in PerMPhi...
  19. Podrez E, Byzova T, Febbraio M, Salomon R, Ma Y, Valiyaveettil M, et al. Platelet CD36 links hyperlipidemia, oxidant stress and a prothrombotic phenotype. Nat Med. 2007;13:1086-95 pubmed
    ..and the generation of biologically active oxidized lipids, including potential ligands for the scavenger receptor CD36, a major platelet glycoprotein...
  20. Hajri T, Han X, Bonen A, Abumrad N. Defective fatty acid uptake modulates insulin responsiveness and metabolic responses to diet in CD36-null mice. J Clin Invest. 2002;109:1381-9 pubmed
    Deficiency of the membrane protein FAT/CD36 causes a marked defect in fatty acid uptake by various tissues and is genetically linked to insulin resistance in rats and humans. Here, we examined insulin responsiveness of CD36-/- mice...
  21. Ip W, Takahashi K, Moore K, Stuart L, Ezekowitz R. Mannose-binding lectin enhances Toll-like receptors 2 and 6 signaling from the phagosome. J Exp Med. 2008;205:169-81 pubmed publisher
    ..Furthermore, we demonstrate that this cooperation occurs within the phagosome, emphasizing the importance of engulfment in providing the appropriate cellular environment to facilitate the synergy between these defense pathways. ..
  22. Harb D, Bujold K, Febbraio M, Sirois M, Ong H, Marleau S. The role of the scavenger receptor CD36 in regulating mononuclear phagocyte trafficking to atherosclerotic lesions and vascular inflammation. Cardiovasc Res. 2009;83:42-51 pubmed publisher
    b>CD36 has been shown to associate with non-receptor Src kinases to activate mitogen-activated protein kinases and trigger cytoskeletal remodelling, important events in foam cell formation and macrophage migration...
  23. Nguyen D, Drover V, Knopfel M, Dhanasekaran P, Hauser H, Phillips M. Influence of class B scavenger receptors on cholesterol flux across the brush border membrane and intestinal absorption. J Lipid Res. 2009;50:2235-44 pubmed publisher
    ..of radioactive cholesterol in mice with scavenger receptor class B, type 1 (SR-BI) and/or cluster determinant 36 (CD36) deleted. The cholesterol absorption efficiency is unaltered by deletion of either one or both of the receptors...
  24. Kennedy D, Kuchibhotla S, Guy E, Park Y, Nimako G, Vanegas D, et al. Dietary cholesterol plays a role in CD36-mediated atherogenesis in LDLR-knockout mice. Arterioscler Thromb Vasc Biol. 2009;29:1481-7 pubmed publisher
    b>CD36 has been shown to play a role in atherosclerosis in the apolipoprotein E-knockout (apoE(o)) mouse. We observed no difference in aortic lesion area between Western diet (WD)-fed LDLR(o) and LDLR(o)/CD36(o) mice...
  25. Bharadwaj K, Hiyama Y, Hu Y, Huggins L, Ramakrishnan R, Abumrad N, et al. Chylomicron- and VLDL-derived lipids enter the heart through different pathways: in vivo evidence for receptor- and non-receptor-mediated fatty acid uptake. J Biol Chem. 2010;285:37976-86 pubmed publisher
    ..lipids, lipoprotein lipid uptake, and gene expression in heart-specific lipoprotein lipase (LpL) knock-out (hLpL0), CD36 knock-out (Cd36(-/-)), and double knock-out (hLpL0/Cd36(-/-)-DKO) mice...
  26. Zhou J, Febbraio M, Wada T, Zhai Y, Kuruba R, He J, et al. Hepatic fatty acid transporter Cd36 is a common target of LXR, PXR, and PPARgamma in promoting steatosis. Gastroenterology. 2008;134:556-67 pubmed publisher
    ..could mediate a Srebp-independent lipogenic pathway by activating the free fatty acid uptake transporter Cd36. The goal of this study is to investigate further the role of Cd36 in hepatic steatosis...
  27. Chung E, Liu J, Homma Y, Zhang Y, Brendolan A, Saggese M, et al. Interleukin-10 expression in macrophages during phagocytosis of apoptotic cells is mediated by homeodomain proteins Pbx1 and Prep-1. Immunity. 2007;27:952-64 pubmed
    ..of transcription in a manner dependent on p38 mitogen-activated protein kinase, partially on the scavenger receptor CD36, and required cell-cell contact but not phagocytosis...
  28. Rahaman S, Lennon D, Febbraio M, Podrez E, Hazen S, Silverstein R. A CD36-dependent signaling cascade is necessary for macrophage foam cell formation. Cell Metab. 2006;4:211-21 pubmed
    ..We demonstrated by coimmunoprecipitation and pull-down assays that the macrophage scavenger receptor CD36 associates with a signaling complex containing Lyn and MEKK2...
  29. Medeiros L, Khan T, El Khoury J, Pham C, Hatters D, Howlett G, et al. Fibrillar amyloid protein present in atheroma activates CD36 signal transduction. J Biol Chem. 2004;279:10643-8 pubmed
    ..We recently reported that the myeloid scavenger receptor CD36 initiates a signaling cascade upon binding to fibrillar beta-amyloid that stimulates recruitment of microglia in ..
  30. Febbraio M, Abumrad N, Hajjar D, Sharma K, Cheng W, Pearce S, et al. A null mutation in murine CD36 reveals an important role in fatty acid and lipoprotein metabolism. J Biol Chem. 1999;274:19055-62 pubmed
    A null mutation in the scavenger receptor gene CD36 was created in mice by targeted homologous recombination. These mice produced no detectable CD36 protein, were viable, and bred normally...
  31. Laugerette F, Passilly Degrace P, Patris B, Niot I, Febbraio M, Montmayeur J, et al. CD36 involvement in orosensory detection of dietary lipids, spontaneous fat preference, and digestive secretions. J Clin Invest. 2005;115:3177-84 pubmed
    ..The fatty acid transporter CD36 appears to be a plausible candidate for this function since it has a high affinity for long-chain fatty acids (..
  32. Bieghs V, Wouters K, van Gorp P, Gijbels M, de Winther M, Binder C, et al. Role of scavenger receptor A and CD36 in diet-induced nonalcoholic steatohepatitis in hyperlipidemic mice. Gastroenterology. 2010;138:2477-86, 2486.e1-3 pubmed publisher
    ..Scavenging of modified lipoproteins mainly depends on CD36 and macrophage scavenger receptor 1...
  33. Endemann G, Stanton L, Madden K, Bryant C, White R, Protter A. CD36 is a receptor for oxidized low density lipoprotein. J Biol Chem. 1993;268:11811-6 pubmed
    ..We have utilized cloning by expression to identify CD36 as a macrophage receptor for OxLDL...
  34. Hoebe K, Georgel P, Rutschmann S, Du X, Mudd S, Crozat K, et al. CD36 is a sensor of diacylglycerides. Nature. 2005;433:523-7 pubmed
    ..Here we show that an N-ethyl-N-nitrosourea-induced nonsense mutation of Cd36 (oblivious) causes a recessive immunodeficiency phenotype in which macrophages are insensitive to the R-enantiomer ..
  35. Podrez E, Poliakov E, Shen Z, Zhang R, Deng Y, Sun M, et al. A novel family of atherogenic oxidized phospholipids promotes macrophage foam cell formation via the scavenger receptor CD36 and is enriched in atherosclerotic lesions. J Biol Chem. 2002;277:38517-23 pubmed
    The macrophage scavenger receptor CD36 plays an important role in binding and uptake of oxidized forms of low-density lipoprotein (LDL), foam cell formation, and lesion development during atherosclerosis...
  36. Kunjathoor V, Febbraio M, Podrez E, Moore K, Andersson L, Koehn S, et al. Scavenger receptors class A-I/II and CD36 are the principal receptors responsible for the uptake of modified low density lipoprotein leading to lipid loading in macrophages. J Biol Chem. 2002;277:49982-8 pubmed
    ..The genetic inactivation of either of two SR family members, SR-A or CD36, has been shown previously to reduce oxidized LDL uptake in vitro and atherosclerotic lesions in mice...
  37. Kennedy D, Kuchibhotla S, Westfall K, Silverstein R, Morton R, Febbraio M. A CD36-dependent pathway enhances macrophage and adipose tissue inflammation and impairs insulin signalling. Cardiovasc Res. 2011;89:604-13 pubmed publisher
    ..by inflammation, oxidant stress, and pathophysiologic oxidized lipids, including ligands for the scavenger receptor CD36. Here we tested the hypothesis that the absence of CD36 protects mice from IR associated with diet-induced obesity ..
  38. Seimon T, Nadolski M, Liao X, Magallon J, Nguyen M, Feric N, et al. Atherogenic lipids and lipoproteins trigger CD36-TLR2-dependent apoptosis in macrophages undergoing endoplasmic reticulum stress. Cell Metab. 2010;12:467-82 pubmed publisher
    ..acids (SFAs), and lipoprotein(a) trigger apoptosis in ER-stressed macrophages through a mechanism requiring both CD36 and Toll-like receptor 2 (TLR2)...
  39. Lovegrove F, Gharib S, Pena Castillo L, Patel S, Ruzinski J, Hughes T, et al. Parasite burden and CD36-mediated sequestration are determinants of acute lung injury in an experimental malaria model. PLoS Pathog. 2008;4:e1000068 pubmed publisher
    ..b>Cd36(-/-) mice, which have decreased parasite lung sequestration, were relatively protected from ALI...
  40. Gaillard D, Laugerette F, Darcel N, El Yassimi A, Passilly Degrace P, Hichami A, et al. The gustatory pathway is involved in CD36-mediated orosensory perception of long-chain fatty acids in the mouse. FASEB J. 2008;22:1458-68 pubmed
    ..We have recently shown that lingual CD36 contributes to fat preference and early digestive secretions in the mouse...
  41. Bao Y, Qin L, Kim E, Bhosle S, Guo H, Febbraio M, et al. CD36 is involved in astrocyte activation and astroglial scar formation. J Cereb Blood Flow Metab. 2012;32:1567-77 pubmed publisher
    ..Previously, we showed that the expression of CD36, an inflammatory mediator, occurs in a subset of astcotyes in the peri-infarct area where the glial scar forms...
  42. Teboul L, Febbraio M, Gaillard D, Amri E, Silverstein R, Grimaldi P. Structural and functional characterization of the mouse fatty acid translocase promoter: activation during adipose differentiation. Biochem J. 2001;360:305-12 pubmed
    b>Fatty acid translocase (FAT/CD36) is a cell-surface glycoprotein that functions as a receptor/transporter for long-chain fatty acids (LCFAs), and interacts with other protein and lipid ligands...
  43. Erdman L, Cosio G, Helmers A, Gowda D, Grinstein S, Kain K. CD36 and TLR interactions in inflammation and phagocytosis: implications for malaria. J Immunol. 2009;183:6452-9 pubmed publisher
    b>CD36 participates in macrophage internalization of a variety of particles, and has been implicated in inflammatory responses to many of these ligands...
  44. Wilkinson K, Boyd J, Glicksman M, Moore K, El Khoury J. A high content drug screen identifies ursolic acid as an inhibitor of amyloid beta protein interactions with its receptor CD36. J Biol Chem. 2011;286:34914-22 pubmed publisher
    ..A? binds to microglia via a receptor complex that includes CD36 leading to production of proinflammatory cytokines and neurotoxic reactive oxygen species and subsequent ..
  45. Moore K, Kunjathoor V, Koehn S, Manning J, Tseng A, Silver J, et al. Loss of receptor-mediated lipid uptake via scavenger receptor A or CD36 pathways does not ameliorate atherosclerosis in hyperlipidemic mice. J Clin Invest. 2005;115:2192-201 pubmed
    ..Two scavenger receptors, scavenger receptor A (SR-A) and CD36, have been centrally implicated in this lipid uptake process...
  46. Nicholls H, Kowalski G, Kennedy D, Risis S, Zaffino L, Watson N, et al. Hematopoietic cell-restricted deletion of CD36 reduces high-fat diet-induced macrophage infiltration and improves insulin signaling in adipose tissue. Diabetes. 2011;60:1100-10 pubmed publisher
    The fatty acid translocase and scavenger receptor CD36 is important in the recognition and uptake of lipids...
  47. Rahaman S, Swat W, Febbraio M, Silverstein R. Vav family Rho guanine nucleotide exchange factors regulate CD36-mediated macrophage foam cell formation. J Biol Chem. 2011;286:7010-7 pubmed publisher
    ..factors impact processes highly relevant to atherogenesis and are involved in pathways common to scavenger receptor CD36 signaling, their role in CD36-dependent macrophage foam cell formation remains unknown...
  48. Stuart L, Deng J, Silver J, Takahashi K, Tseng A, Hennessy E, et al. Response to Staphylococcus aureus requires CD36-mediated phagocytosis triggered by the COOH-terminal cytoplasmic domain. J Cell Biol. 2005;170:477-85 pubmed
    ..scavenger receptor Croquemort as a receptor for Staphylococcus aureus, implicating for the first time the CD36 family as phagocytic receptors for bacteria...
  49. Bonen A, Han X, Habets D, Febbraio M, Glatz J, Luiken J. A null mutation in skeletal muscle FAT/CD36 reveals its essential role in insulin- and AICAR-stimulated fatty acid metabolism. Am J Physiol Endocrinol Metab. 2007;292:E1740-9 pubmed
    b>Fatty acid translocase (FAT)/CD36 is involved in regulating the uptake of long-chain fatty acids into muscle cells. However, the contribution of FAT/CD36 to fatty acid metabolism remains unknown...
  50. Cunha Rodrigues M, Portugal S, Febbraio M, Mota M. Bone marrow chimeric mice reveal a dual role for CD36 in Plasmodium berghei ANKA infection. Malar J. 2007;6:32 pubmed
    ..In vitro studies have shown the relevance of CD36 for adhesion phenotypes of Plasmodium falciparum iRBC such as sequestration, platelet mediated clumping and non-..
  51. Simantov R, Febbraio M, Silverstein R. The antiangiogenic effect of thrombospondin-2 is mediated by CD36 and modulated by histidine-rich glycoprotein. Matrix Biol. 2005;24:27-34 pubmed
    ..the antiangiogenic activity of TSP-1 is mediated by the interaction of the type I repeats (TSR) with the receptor CD36, although other domains of TSP-1 have also been implicated...
  52. Kuchibhotla S, Vanegas D, Kennedy D, Guy E, Nimako G, Morton R, et al. Absence of CD36 protects against atherosclerosis in ApoE knock-out mice with no additional protection provided by absence of scavenger receptor A I/II. Cardiovasc Res. 2008;78:185-96 pubmed
    ..This study addresses the effect of combined absence of scavenger receptors CD36 and SRA I/II on atherosclerosis lesion development in the apolipoprotein E knock-out (apoE degrees ) model...
  53. Stewart C, Stuart L, Wilkinson K, van Gils J, Deng J, Halle A, et al. CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer. Nat Immunol. 2010;11:155-61 pubmed publisher
    ..Assembly of this newly identified heterodimer is regulated by signals from the scavenger receptor CD36, a common receptor for these disparate ligands...
  54. Helming L, Winter J, Gordon S. The scavenger receptor CD36 plays a role in cytokine-induced macrophage fusion. J Cell Sci. 2009;122:453-9 pubmed publisher
    ..Using an antibody screening strategy we found that the scavenger receptor CD36 participates in macrophage fusion induced by the cytokines IL-4 and GM-CSF...
  55. Ghosh A, Li W, Febbraio M, Espinola R, McCrae K, Cockrell E, et al. Platelet CD36 mediates interactions with endothelial cell-derived microparticles and contributes to thrombosis in mice. J Clin Invest. 2008;118:1934-43 pubmed publisher
    b>CD36 is a scavenger receptor that binds multiple ligands, including phosphatidyl serine (PS)...
  56. Liang C, Han S, Okamoto H, Carnemolla R, Tabas I, Accili D, et al. Increased CD36 protein as a response to defective insulin signaling in macrophages. J Clin Invest. 2004;113:764-73 pubmed
    ..ob/ob) mice have increased binding and uptake of oxidized LDL, in part due to a post-transcriptional increase in CD36 protein...
  57. El Yassimi A, Hichami A, Besnard P, Khan N. Linoleic acid induces calcium signaling, Src kinase phosphorylation, and neurotransmitter release in mouse CD36-positive gustatory cells. J Biol Chem. 2008;283:12949-59 pubmed publisher
    We have recently demonstrated that the cells expressing CD36, localized apically on the taste buds of mouse lingual circumvallate papillae, act as gustatory cells...
  58. Koonen D, Sung M, Kao C, Dolinsky V, Koves T, Ilkayeva O, et al. Alterations in skeletal muscle fatty acid handling predisposes middle-aged mice to diet-induced insulin resistance. Diabetes. 2010;59:1366-75 pubmed publisher
    ..Whole-body and skeletal muscle insulin resistance were studied in young and middle-aged wild-type and CD36 knockout (KO) mice fed either a standard or a high-fat diet for 12 weeks...
  59. Goudriaan J, Dahlmans V, Febbraio M, Teusink B, Romijn J, Havekes L, et al. Intestinal lipid absorption is not affected in CD36 deficient mice. Mol Cell Biochem. 2002;239:199-202 pubmed
    Increasing evidence has implicated the membrane protein CD36 (or fatty acid translocase, FAT) to be involved in high affinity fatty acid uptake...
  60. Means T, Mylonakis E, Tampakakis E, Colvin R, Seung E, Puckett L, et al. Evolutionarily conserved recognition and innate immunity to fungal pathogens by the scavenger receptors SCARF1 and CD36. J Exp Med. 2009;206:637-53 pubmed publisher
    ..3, and their mammalian orthologues, the scavenger receptors SCARF1 and CD36, mediate host defense against two prototypic fungal pathogens, Cryptococcus neoformans and Candida albicans...
  61. Manning Tobin J, Moore K, Seimon T, Bell S, Sharuk M, Alvarez Leite J, et al. Loss of SR-A and CD36 activity reduces atherosclerotic lesion complexity without abrogating foam cell formation in hyperlipidemic mice. Arterioscler Thromb Vasc Biol. 2009;29:19-26 pubmed publisher
    The scavenger receptors SR-A and CD36 have been implicated in macrophage foam cell formation during atherogenesis and in the regulation of inflammatory signaling pathways, including those leading to lesional macrophage apoptosis and ..
  62. Drover V, Nguyen D, Bastie C, Darlington Y, Abumrad N, Pessin J, et al. CD36 mediates both cellular uptake of very long chain fatty acids and their intestinal absorption in mice. J Biol Chem. 2008;283:13108-15 pubmed publisher
    ..Here we show that the scavenger receptor CD36 is required both for the uptake of very long chain FAs (VLCFAs) in cultured cells and the absorption of dietary ..
  63. Bodart V, Febbraio M, Demers A, McNicoll N, Pohankova P, Perreault A, et al. CD36 mediates the cardiovascular action of growth hormone-releasing peptides in the heart. Circ Res. 2002;90:844-9 pubmed
    ..The N-terminal sequence determination of the deglycosylated protein was identical to rat CD36, a multifunctional glycoprotein, which was expressed in cardiomyocytes and microvascular endothelial cells...
  64. Kuang M, Febbraio M, Wagg C, Lopaschuk G, Dyck J. Fatty acid translocase/CD36 deficiency does not energetically or functionally compromise hearts before or after ischemia. Circulation. 2004;109:1550-7 pubmed
    Evidence from humans suggests that fatty acid translocase (FAT)/CD36 deficiency can lead to functionally and/or energetically compromised hearts, but the data are equivocal, and the subject remains controversial...
  65. Mwaikambo B, Sennlaub F, Ong H, Chemtob S, Hardy P. Genetic ablation of CD36 induces age-related corneal neovascularization. Cornea. 2008;27:1037-41 pubmed publisher
    ..In the current study, we tested the hypothesis that the CD36+/+ antiangiogenic receptor contributes toward the maintenance of corneal avascularity...
  66. Sclafani A, Ackroff K, Abumrad N. CD36 gene deletion reduces fat preference and intake but not post-oral fat conditioning in mice. Am J Physiol Regul Integr Comp Physiol. 2007;293:R1823-32 pubmed
    Several findings suggest the existence of a "fatty" taste, and the CD36 fatty acid translocase is a candidate taste receptor...
  67. Chen K, Febbraio M, Li W, Silverstein R. A specific CD36-dependent signaling pathway is required for platelet activation by oxidized low-density lipoprotein. Circ Res. 2008;102:1512-9 pubmed publisher
    ..lipoprotein (oxLDL) formed in the setting of hyperlipidemia and atherosclerosis activated platelets in a CD36-dependent manner...
  68. Koonen D, Febbraio M, Bonnet S, Nagendran J, Young M, Michelakis E, et al. CD36 expression contributes to age-induced cardiomyopathy in mice. Circulation. 2007;116:2139-47 pubmed
    ..Associated with this is a dramatic increase in the fatty acid transport protein CD36 in aged hearts compared with young hearts, which suggests that CD36 is a mediator of these multiple metabolic, ..
  69. Goudriaan J, Dahlmans V, Teusink B, Ouwens D, Febbraio M, Maassen J, et al. CD36 deficiency increases insulin sensitivity in muscle, but induces insulin resistance in the liver in mice. J Lipid Res. 2003;44:2270-7 pubmed
    CD36 (fatty acid translocase) is involved in high-affinity peripheral fatty acid uptake. Mice lacking CD36 exhibit increased plasma free fatty acid and triglyceride (TG) levels and decreased glucose levels...
  70. Pohl J, Ring A, Korkmaz U, Ehehalt R, Stremmel W. FAT/CD36-mediated long-chain fatty acid uptake in adipocytes requires plasma membrane rafts. Mol Biol Cell. 2005;16:24-31 pubmed
    ..Indeed, subcellular fractionation demonstrated that plasma membrane fatty acid translocase (FAT/CD36) is exclusively located in lipid rafts, whereas intracellular FAT/CD36 cofractionated with DSMs...
  71. Koonen D, Jacobs R, Febbraio M, Young M, Soltys C, Ong H, et al. Increased hepatic CD36 expression contributes to dyslipidemia associated with diet-induced obesity. Diabetes. 2007;56:2863-71 pubmed
    ..acid uptake may contribute to this, we investigated whether increased expression of a fatty acid transport protein (CD36) in the liver during DIO contributes to the dyslipidemia that precedes development of type 2 diabetes...
  72. Luangrath V, Brodeur M, Rhainds D, Brissette L. Mouse CD36 has opposite effects on LDL and oxidized LDL metabolism in vivo. Arterioscler Thromb Vasc Biol. 2008;28:1290-5 pubmed publisher
    The cluster of differentiation-36 (CD36) is a multifunctional protein which is recognized for its in vitro ability to take up oxidized low-density lipoproteins (oxLDL) in macrophages and is therefore considered atherogenic...
  73. Martin C, Passilly Degrace P, Gaillard D, Merlin J, Chevrot M, Besnard P. The lipid-sensor candidates CD36 and GPR120 are differentially regulated by dietary lipids in mouse taste buds: impact on spontaneous fat preference. PLoS ONE. 2011;6:e24014 pubmed publisher
    ..b>CD36 and GPR120 are LCFA receptors identified in rodent taste bud cells...
  74. El Khoury J, Moore K, Means T, Leung J, Terada K, Toft M, et al. CD36 mediates the innate host response to beta-amyloid. J Exp Med. 2003;197:1657-66 pubmed
    ..b>CD36, a class B scavenger receptor, is expressed on microglia in normal and AD brains and binds to beta-amyloid fibrils ..
  75. Hajri T, Hall A, Jensen D, Pietka T, Drover V, Tao H, et al. CD36-facilitated fatty acid uptake inhibits leptin production and signaling in adipose tissue. Diabetes. 2007;56:1872-80 pubmed
    ..Leptin levels are doubled in the CD36-null mouse, which has impaired cellular fatty acid uptake despite a 40% decrease in fat mass...
  76. Christiaens V, Van Hul M, Lijnen H, Scroyen I. CD36 promotes adipocyte differentiation and adipogenesis. Biochim Biophys Acta. 2012;1820:949-56 pubmed publisher
    b>CD36 is a membrane glycoprotein, contributing to the pathogenesis of metabolic disorders, like obesity, which has become a major health concern worldwide...