Cd2ap

Summary

Gene Symbol: Cd2ap
Description: CD2-associated protein
Alias: AL024079, C78928, METS-1, Mets1, CD2-associated protein, SH3 domain-containing adapter protein, SH3 domain-containing adaptor protein METS-1, mesenchyme to epithelium transition protein, SH3 domains, mesenchyme-to-epithelium transition protein with SH3 domains 1
Species: mouse
Products:     Cd2ap

Top Publications

  1. Grunkemeyer J, Kwoh C, Huber T, Shaw A. CD2-associated protein (CD2AP) expression in podocytes rescues lethality of CD2AP deficiency. J Biol Chem. 2005;280:29677-81 pubmed
    Mice born without CD2-associated protein (CD2AP) develop renal failure and nephrotic syndrome about 4 weeks after birth and die around 6 weeks of age...
  2. Kim E, Lee C, Hyun B, Suh J, Oh Y, Namikawa T, et al. Quantitative trait loci for proteinuria in the focal glomerulosclerosis mouse model. Mamm Genome. 2005;16:242-50 pubmed
    ..These results indicated that the genetic control of proteinuria is complex and the identified QTLs may provide new insights into the pathogenesis of FGS in mice as well as in humans. ..
  3. Shih N, Li J, Cotran R, Mundel P, Miner J, Shaw A. CD2AP localizes to the slit diaphragm and binds to nephrin via a novel C-terminal domain. Am J Pathol. 2001;159:2303-8 pubmed
    b>CD2AP, an adapter protein containing multiple SH3 domains, plays a critical role in kidney function. Mice lacking CD2AP die soon after birth because of kidney failure...
  4. Yaddanapudi S, Altintas M, Kistler A, Fernandez I, Möller C, Wei C, et al. CD2AP in mouse and human podocytes controls a proteolytic program that regulates cytoskeletal structure and cellular survival. J Clin Invest. 2011;121:3965-80 pubmed publisher
    ..injury results in proteinuric kidney disease, and genetic deletion of SD-associated CD2-associated protein (CD2AP) leads to progressive renal failure in mice and humans...
  5. Cormont M, Metón I, Mari M, Monzo P, Keslair F, Gaskin C, et al. CD2AP/CMS regulates endosome morphology and traffic to the degradative pathway through its interaction with Rab4 and c-Cbl. Traffic. 2003;4:97-112 pubmed
    ..We cloned an ubiquitous 80-kDa protein, identical to CD2-associated protein/Cas ligand with multiple SH3 domains (CD2AP/CMS), that interacts with Rab4-Q67L in the yeast two-hybrid system and in vitro...
  6. Lehtonen S, Lehtonen E, Kudlicka K, Holthofer H, Farquhar M. Nephrin forms a complex with adherens junction proteins and CASK in podocytes and in Madin-Darby canine kidney cells expressing nephrin. Am J Pathol. 2004;165:923-36 pubmed
    ..nephrin forms a multiprotein complex with cadherins and p120 catenin and with three scaffolding proteins, ZO-1, CD2AP, and CASK, in kidney glomeruli and when expressed in Madin-Darby canine kidney cells...
  7. Wasik A, Polianskyte Prause Z, Dong M, Shaw A, Yates J, Farquhar M, et al. Septin 7 forms a complex with CD2AP and nephrin and regulates glucose transporter trafficking. Mol Biol Cell. 2012;23:3370-9 pubmed publisher
    ..that the filament-forming GTPase septin 7 is expressed in podocytes and associates with CD2-associated protein (CD2AP) and nephrin, both essential for glomerular ultrafiltration. In addition, septin 7 coimmunoprecipitates with VAMP2...
  8. Shih N, Li J, Karpitskii V, Nguyen A, Dustin M, Kanagawa O, et al. Congenital nephrotic syndrome in mice lacking CD2-associated protein. Science. 1999;286:312-5 pubmed
    CD2-associated protein (CD2AP) is an 80-kilodalton protein that is critical for stabilizing contacts between T cells and antigen-presenting cells...
  9. Lehtonen S, Zhao F, Lehtonen E. CD2-associated protein directly interacts with the actin cytoskeleton. Am J Physiol Renal Physiol. 2002;283:F734-43 pubmed
    CD2-associated protein (CD2AP) is an adapter protein associating with several membrane proteins, including nephrin, mutated in congenital nephrotic syndrome of the Finnish type, and polycystin-2, mutated in type 2 autosomal dominant ..

More Information

Publications65

  1. Dustin M, Olszowy M, Holdorf A, Li J, Bromley S, Desai N, et al. A novel adaptor protein orchestrates receptor patterning and cytoskeletal polarity in T-cell contacts. Cell. 1998;94:667-77 pubmed
    ..This novel protein, called CD2AP, is likely to facilitate receptor patterning in the contact area by linking specific adhesion receptors to the ..
  2. Lehtonen S, Ora A, Olkkonen V, Geng L, Zerial M, Somlo S, et al. In vivo interaction of the adapter protein CD2-associated protein with the type 2 polycystic kidney disease protein, polycystin-2. J Biol Chem. 2000;275:32888-93 pubmed
    ..mesenchyme-to-epithelium transition protein with SH3 domains), has since been cloned as a CD2-associated protein (CD2AP)...
  3. Lehtonen S, Tienari J, Londesborough A, Pirvola U, Ora A, Reima I, et al. CD2-associated protein is widely expressed and differentially regulated during embryonic development. Differentiation. 2008;76:506-17 pubmed publisher
    CD2-associated protein (CD2AP) is an adapter protein that is involved in various signaling and vesicular trafficking processes and also functions as a linker between plasma membrane proteins and the actin cytoskeleton...
  4. Schiffer M, Mundel P, Shaw A, Bottinger E. A novel role for the adaptor molecule CD2-associated protein in transforming growth factor-beta-induced apoptosis. J Biol Chem. 2004;279:37004-12 pubmed
    CD2-associated protein (CD2AP) is an adaptor molecule involved in T cell receptor signaling and podocyte homeostasis. CD2AP-deficient mice develop nephrotic syndrome and renal failure caused by glomerulosclerosis...
  5. Weins A, Wong J, Basgen J, Gupta R, Daehn I, Casagrande L, et al. Dendrin ablation prolongs life span by delaying kidney failure. Am J Pathol. 2015;185:2143-57 pubmed publisher
    ..protein dendrin delays the onset of ESKD, thereby expanding the life span of mice lacking the adapter protein CD2AP. Ablation of dendrin delays onset and severity of proteinuria and podocyte loss...
  6. Kobayashi S, Sawano A, Nojima Y, Shibuya M, Maru Y. The c-Cbl/CD2AP complex regulates VEGF-induced endocytosis and degradation of Flt-1 (VEGFR-1). FASEB J. 2004;18:929-31 pubmed
    ..VEGF stimulation induced a ternary complex of Flt-1, c-Cbl, and CD2AP. Substitution of tyrosine 1333 in Flt-1 with phenylalanine (Y1333F) impaired its binding to c-Cbl...
  7. Zhang C, Jiang H, Chang Y, Fang Z, Sun X, Liu J, et al. Downregulation of CD2-associated protein impaired the physiological functions of podocytes. Cell Biol Int. 2009;33:632-9 pubmed publisher
    Emerging evidences show that CD2-associated protein (CD2AP) is involved in podocyte injury and the pathogenesis of proteinuria. However, the exact molecular mechanism by which CD2AP exerts its biological function is elusive...
  8. Russo L, Srivatsan S, Seaman M, Suleiman H, Shaw A, Comper W. Albuminuria associated with CD2AP knockout mice is primarily due to dysfunction of the renal degradation pathway processing of filtered albumin. FEBS Lett. 2013;587:3738-41 pubmed publisher
    ..The increase in intact albumin excretion rate in Cd2ap knockout mice by >100-fold was not accompanied by equivalent changes in urine flow rate, glomerular filtration ..
  9. Saarikangas J, Mattila P, Varjosalo M, Bovellan M, Hakanen J, Calzada Wack J, et al. Missing-in-metastasis MIM/MTSS1 promotes actin assembly at intercellular junctions and is required for integrity of kidney epithelia. J Cell Sci. 2011;124:1245-55 pubmed publisher
    ..Collectively, these data demonstrate that MIM modulates interplay between the actin cytoskeleton and plasma membrane to promote the maintenance of intercellular contacts in kidney epithelia...
  10. Yu H, Artomov M, Brähler S, Stander M, Shamsan G, Sampson M, et al. A role for genetic susceptibility in sporadic focal segmental glomerulosclerosis. J Clin Invest. 2016;126:1067-78 pubmed publisher
    ..Our analysis supports a broader role for genetic susceptibility of both sporadic and familial cases of FSGS and provides a tool to rapidly evaluate candidate FSGS-associated genes. ..
  11. Ubelmann F, Burrinha T, Salavessa L, Gomes R, Ferreira C, Moreno N, et al. Bin1 and CD2AP polarise the endocytic generation of beta-amyloid. EMBO Rep. 2017;18:102-122 pubmed publisher
    ..Two late-onset AD risk factors, Bin1 and CD2AP, are regulators of endocytic trafficking, but it is unclear how their endocytic function regulates A? generation ..
  12. Doné S, Takemoto M, He L, Sun Y, Hultenby K, Betsholtz C, et al. Nephrin is involved in podocyte maturation but not survival during glomerular development. Kidney Int. 2008;73:697-704 pubmed
    ..Nephrin does not seem to have a primary role in cell survival but has a small impact on gene regulation during glomerular development. ..
  13. Tsuji K, Suleiman H, Miner J, Daley J, Capen D, Paunescu T, et al. Ultrastructural Characterization of the Glomerulopathy in Alport Mice by Helium Ion Scanning Microscopy (HIM). Sci Rep. 2017;7:11696 pubmed publisher
    ..Our study demonstrates that HIM provides nanometer resolution to uncover and rediscover critical ultrastructural characteristics of the glomerulopathy in Col4a3 mutant mice. ..
  14. Fukusumi Y, Wakamatsu A, Takashima N, Hasegawa E, Miyauchi N, Tomita M, et al. SV2B is essential for the integrity of the glomerular filtration barrier. Lab Invest. 2015;95:534-45 pubmed publisher
    ..It was also found that the expression of CD2AP, nephrin, and NEPH1, the functional molecules of the slit diaphragm, and laminin, a critical component of the GBM, ..
  15. Tossidou I, Niedenthal R, Klaus M, Teng B, Worthmann K, King B, et al. CD2AP regulates SUMOylation of CIN85 in podocytes. Mol Cell Biol. 2012;32:1068-79 pubmed publisher
    ..Disruption of the slit diaphragm can lead to massive proteinuria and nephrotic syndrome in mice and humans. CD2AP is an adaptor protein that is important for the maintenance of the slit diaphragm...
  16. Tolvanen T, Dash S, Polianskyte Prause Z, Dumont V, Lehtonen S. Lack of CD2AP disrupts Glut4 trafficking and attenuates glucose uptake in podocytes. J Cell Sci. 2015;128:4588-600 pubmed publisher
    The adapter protein CD2-associated protein (CD2AP) functions in various signaling and vesicle trafficking pathways, including endosomal sorting and/or trafficking and degradation pathways...
  17. Tsui C, Pierchala B. CD2AP and Cbl-3/Cbl-c constitute a critical checkpoint in the regulation of ret signal transduction. J Neurosci. 2008;28:8789-800 pubmed publisher
    ..that control the half-life of Ret, we have identified two novel Ret interactors, CD2-associated protein (CD2AP) and Cbl-3...
  18. Sadl V, Jin F, Yu J, Cui S, Holmyard D, Quaggin S, et al. The mouse Kreisler (Krml1/MafB) segmentation gene is required for differentiation of glomerular visceral epithelial cells. Dev Biol. 2002;249:16-29 pubmed
    ..However, these observations alone are unlikely to account for the aberrant podocyte foot process formation. Thus, Kreisler must regulate other unknown genes required for podocyte function and with possible roles in kidney disease. ..
  19. Tossidou I, Kardinal C, Peters I, Kriz W, Shaw A, Dikic I, et al. CD2AP/CIN85 balance determines receptor tyrosine kinase signaling response in podocytes. J Biol Chem. 2007;282:7457-64 pubmed
    ..CD2-associated protein (CD2AP) is highly expressed in podocytes and is considered to play an important role in the maintenance of the glomerular ..
  20. Srivatsan S, Swiecki M, Otero K, Cella M, Shaw A. CD2-associated protein regulates plasmacytoid dendritic cell migration, but is dispensable for their development and cytokine production. J Immunol. 2013;191:5933-40 pubmed publisher
    ..The scaffold protein, CD2-associated protein (CD2AP), is a marker of human pDCs as it is highly expressed in this cell type...
  21. Xiao Z, Rodriguez P, He L, Betsholtz C, Tryggvason K, Patrakka J. Wtip- and gadd45a-interacting protein dendrin is not crucial for the development or maintenance of the glomerular filtration barrier. PLoS ONE. 2013;8:e83133 pubmed publisher
    ..fact that mutations in molecular components of the slit diaphragm, including nephrin and Cd2-associated protein (Cd2ap), result in proteinuric diseases in man...
  22. Brunskill E, Potter S. Pathogenic pathways are activated in each major cell type of the glomerulus in the Cd2ap mutant mouse model of focal segmental glomerulosclerosis. BMC Nephrol. 2015;16:71 pubmed publisher
    Mutations in several genes expressed in podocytes, including Cd2ap, have been associated with focal segmental glomerulosclerosis in humans...
  23. Roselli S, Heidet L, Sich M, Henger A, Kretzler M, Gubler M, et al. Early glomerular filtration defect and severe renal disease in podocin-deficient mice. Mol Cell Biol. 2004;24:550-60 pubmed
    ..modified in Nphs2-/- kidneys: the expression of the nephrin gene was downregulated, whereas that of the ZO1 and CD2AP genes appeared to be upregulated...
  24. Welsch T, Endlich N, Gökce G, Doroshenko E, Simpson J, Kriz W, et al. Association of CD2AP with dynamic actin on vesicles in podocytes. Am J Physiol Renal Physiol. 2005;289:F1134-43 pubmed
    The docking protein CD2AP (CD2-associated protein) serves a nonredundant function in podocytes as CD2AP knockout mice die of renal failure at the age of 6-7 wk...
  25. Tossidou I, Teng B, Drobot L, Meyer Schwesinger C, Worthmann K, Haller H, et al. CIN85/RukL is a novel binding partner of nephrin and podocin and mediates slit diaphragm turnover in podocytes. J Biol Chem. 2010;285:25285-95 pubmed publisher
    ..We can demonstrate that the loss of nephrin expression and onset of the proteinuria in CD2AP(-/-) mice correlates with an increased accumulation of ubiquitinated proteins and expression of CIN85/Ruk(L) in ..
  26. Park H, Seong S, Min S, Ha T. CD2-associated protein/phosphoinositide 3-kinase signaling has a preventive role in angiotensin II-induced podocyte apoptosis. Int J Biochem Cell Biol. 2016;79:370-381 pubmed publisher
    ..barrier and is linked to the actin-based cytoskeleton by adaptor proteins, including CD2-associated protein (CD2AP)...
  27. Jansson S, Olkkonen V, Martin Parras L, Chavrier P, Stapleton M, Zerial M, et al. Mouse metanephric kidney as a model system for identifying developmentally regulated genes. J Cell Physiol. 1997;173:147-51 pubmed
  28. Xavier S, Niranjan T, Krick S, Zhang T, Ju W, Shaw A, et al. TbetaRI independently activates Smad- and CD2AP-dependent pathways in podocytes. J Am Soc Nephrol. 2009;20:2127-37 pubmed publisher
    ..pathways such as phosphoinositide-3 kinase (PI3K)/AKT; the latter requires the CD2-associated adaptor protein (CD2AP) in podocytes...
  29. Kim J, Wu H, Green G, Winkler C, Kopp J, Miner J, et al. CD2-associated protein haploinsufficiency is linked to glomerular disease susceptibility. Science. 2003;300:1298-300 pubmed
    Loss of CD2-associated protein (CD2AP), a component of the filtration complex in the kidney, causes death in mice at 6 weeks of age...
  30. Harrison B, Venkat G, Lamb J, Hutson T, Drury C, Rau K, et al. The Adaptor Protein CD2AP Is a Coordinator of Neurotrophin Signaling-Mediated Axon Arbor Plasticity. J Neurosci. 2016;36:4259-75 pubmed publisher
    ..rat in vivo spared dermatome model of collateral sprouting identified the adaptor protein CD2-associated protein (CD2AP; human CMS) as a positive regulator of axon growth...
  31. Schwarz K, Simons M, Reiser J, Saleem M, Faul C, Kriz W, et al. Podocin, a raft-associated component of the glomerular slit diaphragm, interacts with CD2AP and nephrin. J Clin Invest. 2001;108:1621-9 pubmed
    ..Moreover, GST pull-down experiments reveal that podocin associates via its COOH-terminal domain with CD2AP, a cytoplasmic binding partner of nephrin, and with nephrin itself...
  32. Jarad G, Cunningham J, Shaw A, Miner J. Proteinuria precedes podocyte abnormalities inLamb2-/- mice, implicating the glomerular basement membrane as an albumin barrier. J Clin Invest. 2006;116:2272-9 pubmed
    ..Increased ferritin permeability was not observed in nephrotic CD2-associated protein-null (Cd2ap-/-) mice, which have a primary podocyte defect...
  33. Liu G, Clement L, Kanwar Y, Avila Casado C, Chugh S. ZHX proteins regulate podocyte gene expression during the development of nephrotic syndrome. J Biol Chem. 2006;281:39681-92 pubmed
    ..In summary, ZHX proteins are major transcriptional mediators of podocyte disease. ..
  34. Casalena G, Krick S, Daehn I, Yu L, Ju W, Shi S, et al. Mpv17 in mitochondria protects podocytes against mitochondrial dysfunction and apoptosis in vivo and in vitro. Am J Physiol Renal Physiol. 2014;306:F1372-80 pubmed publisher
    ..In summary, the inner mitochondrial membrane protein Mpv17 in podocytes is essential for the maintenance of mitochondrial homeostasis and protects podocytes against oxidative stress-induced injury both in vitro and in vivo. ..
  35. Gaidos G, Soni S, Oswald D, Toselli P, Kirsch K. Structure and function analysis of the CMS/CIN85 protein family identifies actin-bundling properties and heterotypic-complex formation. J Cell Sci. 2007;120:2366-77 pubmed
  36. Peters I, Tossidou I, Achenbach J, Woroniecki R, Mengel M, Park J, et al. IGF-binding protein-3 modulates TGF-beta/BMP-signaling in glomerular podocytes. J Am Soc Nephrol. 2006;17:1644-56 pubmed
    Podocyte apoptosis initiates progressive glomerulosclerosis in TGF-beta1 transgenic and CD2AP-knockout (CD2AP-/-) mice...
  37. Fan Q, Xing Y, Ding J, Guan N, Zhang J. The relationship among nephrin, podocin, CD2AP, and alpha-actinin might not be a true 'interaction' in podocyte. Kidney Int. 2006;69:1207-15 pubmed
    The abnormality of a single podocyte molecule, caused by a single gene mutation, such as NPHS1, NPHS2, CD2AP, and ACTN4, can lead to the hereditary/congenital nephrotic syndromes (NS)...
  38. Kuusela S, Wang H, Wasik A, Suleiman H, Lehtonen S. Tankyrase inhibition aggravates kidney injury in the absence of CD2AP. Cell Death Dis. 2016;7:e2302 pubmed publisher
    ..We found that tankyrases interact with CD2-associated protein (CD2AP), a protein essential for kidney ultrafiltration as CD2AP-knockout (CD2AP-/-) mice die of kidney failure at the ..
  39. Pozzi A, Jarad G, Moeckel G, Coffa S, Zhang X, Gewin L, et al. Beta1 integrin expression by podocytes is required to maintain glomerular structural integrity. Dev Biol. 2008;316:288-301 pubmed publisher
    ..Thus, expression of beta1 containing integrins by the podocyte is critical for maintaining the structural integrity of the glomerulus. ..
  40. Bredemeyer A, Geahlen J, Weis V, Huh W, Zinselmeyer B, Srivatsan S, et al. The gastric epithelial progenitor cell niche and differentiation of the zymogenic (chief) cell lineage. Dev Biol. 2009;325:211-24 pubmed publisher
    ..We induced this PC mislocalization by knocking out the cytoskeleton-regulating gene Cd2ap in Mist1(-/-) mice, which led to aberrant E-cadherin localization in ZCs, irregular ZC-ZC junctions, and ..
  41. Liao F, Jiang H, Srivatsan S, Xiao Q, Lefton K, Yamada K, et al. Effects of CD2-associated protein deficiency on amyloid-β in neuroblastoma cells and in an APP transgenic mouse model. Mol Neurodegener. 2015;10:12 pubmed publisher
    CD2-associated protein (CD2AP) is an SH3-containing scaffold adaptor protein which regulates the actin cytoskeleton...
  42. Kato T, Mizuno Horikawa Y, Mizuno S. Decreases in podocin, CD2-associated protein (CD2AP) and tensin2 may be involved in albuminuria during septic acute renal failure. J Vet Med Sci. 2011;73:1579-84 pubmed
    ..There is now ample evidence that SD- and FP-associated molecules, such as podocin and CD2-associated protein (CD2AP), are down-regulated during albuminuria of chronic kidney disease...
  43. Schiffer M, Teng B, Gu C, Shchedrina V, Kasaikina M, Pham V, et al. Pharmacological targeting of actin-dependent dynamin oligomerization ameliorates chronic kidney disease in diverse animal models. Nat Med. 2015;21:601-9 pubmed publisher
  44. Zhao J, Bruck S, Cemerski S, Zhang L, Butler B, Dani A, et al. CD2AP links cortactin and capping protein at the cell periphery to facilitate formation of lamellipodia. Mol Cell Biol. 2013;33:38-47 pubmed publisher
    ..b>CD2AP is a membrane scaffold protein implicated in a variety of physiological and disease processes...
  45. Wu F, Saleem M, Kampik N, Satchwell T, Williamson R, Blattner S, et al. Anion exchanger 1 interacts with nephrin in podocytes. J Am Soc Nephrol. 2010;21:1456-67 pubmed publisher
    ..These data suggest that the podocyte protein kAE1 interacts with nephrin and ILK to maintain the structure and function of the glomerular basement membrane. ..
  46. Schell C, Kretz O, Bregenzer A, Rogg M, Helmstädter M, Lisewski U, et al. Podocyte-Specific Deletion of Murine CXADR Does Not Impair Podocyte Development, Function or Stress Response. PLoS ONE. 2015;10:e0129424 pubmed publisher
    ..Thus these data indicate that in contrast to lower vertebrate models, mammalian podocytes have acquired molecular programs to compensate for the loss of Cxadr. ..
  47. Teng B, Schroder P, Müller Deile J, Schenk H, Staggs L, Tossidou I, et al. CIN85 Deficiency Prevents Nephrin Endocytosis and Proteinuria in Diabetes. Diabetes. 2016;65:3667-3679 pubmed
    ..CIN85/RukL expression therefore shows potential to be a novel target for antiproteinuric therapy in diabetes. ..
  48. Reiser J, Polu K, Möller C, Kenlan P, Altintas M, Wei C, et al. TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function. Nat Genet. 2005;37:739-44 pubmed
    ..Two of the TRPC6 mutants had increased current amplitudes. These data show that TRPC6 channel activity at the slit diaphragm is essential for proper regulation of podocyte structure and function. ..
  49. Lee K, Dinner A, Tu C, Campi G, Raychaudhuri S, Varma R, et al. The immunological synapse balances T cell receptor signaling and degradation. Science. 2003;302:1218-22 pubmed
    ..We use in vitro and in silico experiments to determine that the immunological synapse acts as a type of adaptive controller that both boosts T cell receptor triggering and attenuates strong signals. ..
  50. Schiffer M, Schiffer L, Gupta A, Shaw A, Roberts I, Mundel P, et al. Inhibitory smads and tgf-Beta signaling in glomerular cells. J Am Soc Nephrol. 2002;13:2657-66 pubmed
    ..These data indicate an important role for Smad6 and Smad7 in glomerular cells in vivo that could be important for the cell homeostasis in physiologic and pathologic conditions. ..
  51. Tarttelin E, Bellingham J, Hankins M, Foster R, Lucas R. Neuropsin (Opn5): a novel opsin identified in mammalian neural tissue. FEBS Lett. 2003;554:410-6 pubmed
    ..Neuropsin shares 25-30% amino acid identity with all known opsins, making it the founding member of a new opsin family. It is expressed in the eye, brain, testis and spinal cord. ..
  52. Cullen S, Adrain C, Lüthi A, Duriez P, Martin S. Human and murine granzyme B exhibit divergent substrate preferences. J Cell Biol. 2007;176:435-44 pubmed
    ..These data demonstrate that human and murine GzmB are distinct enzymes with different substrate preferences. Our observations also illustrate how subtle differences in enzyme structure can radically affect substrate selection. ..
  53. Cochran J, Rush T, Buckingham S, Roberson E. The Alzheimer's disease risk factor CD2AP maintains blood-brain barrier integrity. Hum Mol Genet. 2015;24:6667-74 pubmed publisher
    CD2-associated protein (CD2AP) is a leading genetic risk factor for Alzheimer's disease, but little is known about the function of CD2AP in the brain. We studied CD2AP(-/-) mice to address this question...
  54. Calco G, Stephens O, Donahue L, Tsui C, Pierchala B. CD2-associated protein (CD2AP) enhances casitas B lineage lymphoma-3/c (Cbl-3/c)-mediated Ret isoform-specific ubiquitination and degradation via its amino-terminal Src homology 3 domains. J Biol Chem. 2014;289:7307-19 pubmed publisher
    ..sympathetic neurons, Ret degradation is induced, at least in part, by a complex consisting of the adaptor protein CD2AP and the E3-ligase Cbl-3/c...
  55. Huber T, Kwoh C, Wu H, Asanuma K, Gödel M, Hartleben B, et al. Bigenic mouse models of focal segmental glomerulosclerosis involving pairwise interaction of CD2AP, Fyn, and synaptopodin. J Clin Invest. 2006;116:1337-45 pubmed
    ..proteins have been implicated in the etiology of FSGS, including podocin, alpha-actinin-4, CD2-associated protein (CD2AP), and TRPC6...
  56. Voisinne G, García Blesa A, Chaoui K, Fiore F, Bergot E, Girard L, et al. Co-recruitment analysis of the CBL and CBLB signalosomes in primary T cells identifies CD5 as a key regulator of TCR-induced ubiquitylation. Mol Syst Biol. 2016;12:876 pubmed publisher
    ..Our results offer an integrated view of the CBL and CBLB signaling complexes induced by TCR stimulation and provide a molecular basis for their negative regulatory function in normal T cells. ..