CD28

Summary

Gene Symbol: CD28
Description: CD28 antigen
Alias: OTTMUSP00000002157, T-cell-specific surface glycoprotein CD28
Species: mouse

Publications

  1. CD28/B7-mediated co-stimulation is critical for early control of murine cytomegalovirus infection
    Charles H Cook
    Department of Surgery, Ohio State University Medical College, Columbus, Ohio 43210, USA
    Viral Immunol 22:91-103
  2. A novel role for CD28 in thymic selection: elimination of CD28/B7 interactions increases positive selection
    Melanie S Vacchio
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, USA
    Eur J Immunol 35:418-27
  3. CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2
    Xuguang Tai
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Immunol 6:152-62
  4. ICOS costimulates invariant NKT cell activation
    Hiroshi Kaneda
    Department of Immunology, Juntendo University School of Medicine, Tokyo 113 8421, Japan
    Biochem Biophys Res Commun 327:201-7
  5. A new role for CD28 in the survival of autoreactive T cells in the periphery after chronic exposure to autoantigen
    Jian Xin Gao
    Division of Cancer Immunology, Department of Pathology, Ohio State University Medical Center, Columbus, OH 43210, USA
    Int Immunol 16:1403-9
  6. CD28 costimulation controls histone hyperacetylation of the interleukin 5 gene locus in developing th2 cells
    Masamichi Inami
    Department of Immunology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana Chuo ku, Chiba 260 8670, Japan
    J Biol Chem 279:23123-33
  7. Distinct regions in the CD28 cytoplasmic domain are required for T helper type 2 differentiation
    Pietro G Andres
    Division of Gastroenterology, Department of Medicine, University of California, San Francisco, California 94143, USA
    Nat Immunol 5:435-42
  8. A switch in costimulation from CD28 to 4-1BB during primary versus secondary CD8 T cell response to influenza in vivo
    Edward M Bertram
    Department of Immunology, University of Toronto, Toronto, Ontario, Canada M5S 1A8
    J Immunol 172:981-8
  9. Regulatory functions of CD8+CD28- T cells in an autoimmune disease model
    Nader Najafian
    Brigham and Women s Hospital, Boston, Massachusetts, USA
    J Clin Invest 112:1037-48
  10. Islet allograft rejection in nonobese diabetic mice involves the common gamma-chain and CD28/CD154-dependent and -independent mechanisms
    Gulcin Demirci
    Department of Medicine, Harvard Medical School, Division of Immunology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Immunol 171:3878-85

Scientific Experts

Detail Information

Publications62

  1. CD28/B7-mediated co-stimulation is critical for early control of murine cytomegalovirus infection
    Charles H Cook
    Department of Surgery, Ohio State University Medical College, Columbus, Ohio 43210, USA
    Viral Immunol 22:91-103
    ..Although CD28/B7 plays a clear role in T-cell responses in many antigen systems including some viral infections, the importance ..
  2. A novel role for CD28 in thymic selection: elimination of CD28/B7 interactions increases positive selection
    Melanie S Vacchio
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, USA
    Eur J Immunol 35:418-27
    While the importance of the CD28/B7 costimulation pathway is well established for mature T cells, the role of CD28 in thymocyte selection is less well defined...
  3. CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2
    Xuguang Tai
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Immunol 6:152-62
    Efficient generation of regulatory T cells (T(reg) cells) in the thymus requires CD28 costimulation, but it is not known why...
  4. ICOS costimulates invariant NKT cell activation
    Hiroshi Kaneda
    Department of Immunology, Juntendo University School of Medicine, Tokyo 113 8421, Japan
    Biochem Biophys Res Commun 327:201-7
    It has been reported that costimulatory molecules, CD80/86-CD28 and CD154-CD40, critically contribute to activation of CD1d-restricted invariant NKT (iNKT) cells...
  5. A new role for CD28 in the survival of autoreactive T cells in the periphery after chronic exposure to autoantigen
    Jian Xin Gao
    Division of Cancer Immunology, Department of Pathology, Ohio State University Medical Center, Columbus, OH 43210, USA
    Int Immunol 16:1403-9
    ..The role of CD28 in the survival of autoreactive T cells in the periphery, however, has not been reported...
  6. CD28 costimulation controls histone hyperacetylation of the interleukin 5 gene locus in developing th2 cells
    Masamichi Inami
    Department of Immunology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana Chuo ku, Chiba 260 8670, Japan
    J Biol Chem 279:23123-33
    ..Here we studied the role of CD28 costimulation in the generation of IL-5-producing cells and the histone hyperacetylation of the IL-5 gene locus...
  7. Distinct regions in the CD28 cytoplasmic domain are required for T helper type 2 differentiation
    Pietro G Andres
    Division of Gastroenterology, Department of Medicine, University of California, San Francisco, California 94143, USA
    Nat Immunol 5:435-42
    b>CD28 costimulation is essential for CD4(+) T cell proliferation, survival, interleukin 2 (IL-2) production and T helper type 2 development...
  8. A switch in costimulation from CD28 to 4-1BB during primary versus secondary CD8 T cell response to influenza in vivo
    Edward M Bertram
    Department of Immunology, University of Toronto, Toronto, Ontario, Canada M5S 1A8
    J Immunol 172:981-8
    ..In contrast, CD28(-/-) mice are defective in initial CD8 T cell expansion...
  9. Regulatory functions of CD8+CD28- T cells in an autoimmune disease model
    Nader Najafian
    Brigham and Women s Hospital, Boston, Massachusetts, USA
    J Clin Invest 112:1037-48
    CD8+ T cell depletion renders CD28-deficient mice susceptible to experimental autoimmune encephalomyelitis (EAE). In addition, CD8-/-CD28-/- double-knockout mice are susceptible to EAE...
  10. Islet allograft rejection in nonobese diabetic mice involves the common gamma-chain and CD28/CD154-dependent and -independent mechanisms
    Gulcin Demirci
    Department of Medicine, Harvard Medical School, Division of Immunology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Immunol 171:3878-85
    ..NOD mouse is determined by the interplay of diverse islet-specific T cell subsets whose activation is regulated by CD28/CD154 costimulatory signals and the common gamma-chain (gammac; a shared signaling element by receptors for IL-2, ..
  11. Constitutive expression of a costimulatory ligand on antigen-presenting cells in the nervous system drives demyelinating disease
    Simone P Zehntner
    Neuroimmunology Unit, Montreal Neurological Institute, Montreal, Quebec, Canada
    FASEB J 17:1910-2
    ..2 transgenic recipients but not into non-transgenic recipients. These data provide evidence that B7/CD28 interactions within the nervous tissue are critical determinants of disease development...
  12. Role of CD4 T cell help and costimulation in CD8 T cell responses during Listeria monocytogenes infection
    Devon J Shedlock
    Department of Microbiology, School of Medicine, University of Pennsylvania, 3610 Hamilton Walk, Philadelphia, PA 19104 6076, USA
    J Immunol 170:2053-63
    ..The CD8 T cell response to L. monocytogenes was normal in CD40L(-/-) mice but defective in CD28(-/-) and CD137L(-/-) mice...
  13. CD70 signaling is critical for CD28-independent CD8+ T cell-mediated alloimmune responses in vivo
    Akira Yamada
    Transplantation Research Center, Brigham and Women s Hospital and Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 174:1357-64
    The inability to reproducibly induce robust and durable transplant tolerance using CD28-B7 pathway blockade is in part related to the persistence of alloreactive effector/memory CD8(+) T cells that are less dependent on this pathway for ..
  14. Costimulation through NKG2D enhances murine CD8+ CTL function: similarities and differences between NKG2D and CD28 costimulation
    Mary A Markiewicz
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 175:2825-33
    ..We found that NKG2D was able to costimulate DUC CTL responses and did so in a manner similar to CD28 costimulation...
  15. B7+ iris pigment epithelium induce CD8+ T regulatory cells; both suppress CTLA-4+ T cells
    Sunao Sugita
    Department of Ophthalmology, Schepens Eye Research Institute, Harvard Medical School, Boston, MA 02114, USA
    J Immunol 176:118-27
    ....
  16. Functional hierarchy and relative contribution of the CD28/B7 and ICOS/B7-H2 costimulatory pathways to T cell-mediated delayed-type hypersensitivity
    Siew Cheng Wong
    Bioprocessing Technology Institute, Agency for Science, Technology and Research, Singapore, Singapore
    Cell Immunol 256:64-71
    The CD28/B7 and ICOS/B7-H2 pathways are both critical for costimulating T cell immune responses. Deficiency in either pathway results in defective T cell activation, cytokine production and germinal center formation...
  17. CTLA-4 on alloreactive CD4 T cells interacts with recipient CD80/86 to promote tolerance
    Josef Kurtz
    Bone Marrow Transplantation Section, Transplantation Biology Research Center, Massachusetts General Hospital Harvard Medical School, Boston, MA 02129, USA
    Blood 113:3475-84
    ..Animals lacking CD80 and CD86 failed to achieve chimerism. We detected no T cell-intrinsic requirement for CD28 for chimerism induction...
  18. Gold- and silver-induced murine autoimmunity--requirement for cytokines and CD28 in murine heavy metal-induced autoimmunity
    S Havarinasab
    Molecular and Immunological Pathology, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden
    Clin Exp Immunol 155:567-76
    ..study we have examined the effect of single-gene deletions for interferon (IFN)-gamma, interleukin (IL)-4, IL-6 or CD28 in B10.S (H-2(s)) mice on heavy metal-induced autoimmunity...
  19. Locally produced complement fragments C5a and C3a provide both costimulatory and survival signals to naive CD4+ T cells
    Michael G Strainic
    Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA
    Immunity 28:425-35
    ..with their G protein-coupled receptors (GPCRs), C5aR and C3aR, on APCs and T cells both upstream and downstream of CD28 and CD40L signaling are integrally involved in T cell proliferation and differentiation...
  20. T cell receptor-induced phosphoinositide-3-kinase p110delta activity is required for T cell localization to antigenic tissue in mice
    Sarah J Jarmin
    Department of Immunology, Division of Medicine, Imperial College London, Hammersmith Campus, London, United Kingdom
    J Clin Invest 118:1154-64
    ..These observations suggest that pharmacological targeting of p110delta activity is a viable strategy for the therapy of T cell-mediated pathology...
  21. Importance of CD80/CD86-CD28 interactions in the recognition of target cells by CD8+CD122+ regulatory T cells
    Zhe Shi
    Department of Immunology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Immunology 124:121-8
    ..produced IL-10 and suppressed the IFN-gamma production of target cells when stimulated by anti-CD3 plus anti-CD28-coated beads...
  22. Requirements for selection of conventional and innate T lymphocyte lineages
    Reiko Horai
    National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 27:775-85
    ..Acquisition of their innate characteristics, however, required CD28. Our results suggest that SAP and Itk reciprocally regulate selection of innate and conventional CD8(+) T cells on ..
  23. Glucocorticoid-induced TNFR-related protein lowers the threshold of CD28 costimulation in CD8+ T cells
    Simona Ronchetti
    Dipartimento di Medicina Clinica e Sperimentale, Sezione di Farmacologia, Tossicologia e Chemioterapia, Università di Perugia, and IBiT Foundation, Perugia, Italy
    J Immunol 179:5916-26
    b>CD28 is well characterized as a costimulatory molecule in T cell activation. Recent evidences indicate that TNFR superfamily members, including glucocorticoid-induced TNFR-related protein (GITR), act as costimulatory molecules...
  24. The CD28/CTLA-4-B7 signaling pathway is involved in both allergic sensitization and tolerance induction to orally administered peanut proteins
    Femke van Wijk
    Utrecht University, Institute for Risk Assessment Sciences, Department of Immunotoxicology, Utrecht, The Netherlands
    J Immunol 178:6894-900
    ..The CD28/CTLA-4-CD80/CD86 signaling pathway appears to be one of the most important regulators of T cell responses but its ..
  25. Duration of CTL activation regulates IL-2 production required for autonomous clonal expansion
    Diana C J Spierings
    La Jolla Institute for Allergy and Immunology, San Diego, CA, USA
    Eur J Immunol 36:1707-17
    ..These results indicate that the nature and duration of antigenic stimulation regulate the autonomy of CTL expansion via the production of autocrine IL-2...
  26. T-cell tolerance or function is determined by combinatorial costimulatory signals
    Roza Nurieva
    Department of Immunology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    EMBO J 25:2623-33
    Activated in immune responses, T lymphocytes differentiate into effector cells with potent immune function. CD28 is the most prominent costimulatory receptor for T-cell activation...
  27. CD28 is required for induction and maintenance of immunological memory in toxin-reactive CD4+ T cells in vivo
    Kenji Fukada
    Department of Oral and Maxillofacial Surgery, Tokyo Women s Medical University School of Medicine, Tokyo, Japan
    Cell Immunol 238:103-12
    ..In the present study, we followed the fate of Vbeta3+ CD4+ T cells in CD28-/- mice...
  28. Engagement of CD28 outside of the immunological synapse results in up-regulation of IL-2 mRNA stability but not IL-2 transcription
    Mariano Sanchez Lockhart
    David H Smith Center for Vaccine Biology and Immunology, Aab Institute of Biomedical Sciences and the Department of Microbiology and Immunology, University of Rochester, Rochester, NY 14642, USA
    J Immunol 176:4778-84
    During T cell activation by APC, CD28 is colocalized with TCR in the central supramolecular activation cluster (cSMAC) region of the immunological synapse...
  29. A single amino acid alteration in cytoplasmic domain determines IL-2 promoter activation by ligation of CD28 but not inducible costimulator (ICOS)
    Yohsuke Harada
    Research Institute for Biological Sciences, Faculty of Science and Technology, Tokyo University of Science, 2669 Yamazaki, Noda, Chiba 278 0022, Japan
    J Exp Med 197:257-62
    The CD28 family molecules, CD28, and inducible costimulator (ICOS) all provide positive costimulatory signals. However, unlike CD28, ICOS does not costimulate IL-2 secretion...
  30. Expression of CD28 by bone marrow stromal cells and its involvement in B lymphopoiesis
    Kirstin Gray Parkin
    Program for Immunology and Aging, Department of Cell Biology, Neurobiology, and Anatomy, Loyola University Medical Center, Maywood, IL 60153, USA
    J Immunol 169:2292-302
    Young mice lacking CD28 have normal numbers of peripheral B cells; however, abnormalities exist in the humoral immune response that may result from an intrinsic defect in the B cells...
  31. The role of B7 costimulation in CD4/CD8 T cell homeostasis
    X Yu
    Experimental Immunology Branch, National Cancer Institute, and National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 164:3543-53
    ..B7-induced T cell expansion was dependent on both CD28 and TCR expression...
  32. Role of CD28 in the generation of effector and memory responses required for resistance to Toxoplasma gondii
    E N Villegas
    Department of Pathobiology, University of Pennsylvania, Philadelphia 19104, USA
    J Immunol 163:3344-53
    b>CD28 deficient (CD28-/-) mice were used to study the role of costimulation in the T cell-mediated, IFN-gamma-dependent mechanism of resistance to Toxoplasma gondii. These mice were resistant to infection with the ME49 strain of T. gondii...
  33. Several different cell surface molecules control negative selection of medullary thymocytes
    H Kishimoto
    Department of Immunology, Scripps Research Institute, La Jolla, California 92037, USA
    J Exp Med 190:65-73
    ..In support of this idea, we show here that at least three cell surface molecules, namely CD28, CD5, and CD43, contribute to Fas-independent negative selection of the tolerance-susceptible population of heat-..
  34. Synergy between CD28 and CD9 costimulation for naive T-cell activation
    K Toyo oka
    Biomedical Research Center, Osaka University Medical School, Japan
    Immunol Lett 58:19-23
    ..expressed on most mature naive T-cells and delivers a potent costimulatory signal that functions independently of CD28. Here, we investigated whether this CD9-mediated signal is different from the CD28-mediated signal in the mode of ..
  35. Interleukin-12-activated natural killer cells recognize B7 costimulatory molecules on tumor cells and autologous dendritic cells
    A B Geldhof
    Laboratory of Cellular Immunology, Flanders Interuniversity Institute for Biotechnology, Vrije Universiteit Brussel VUB, Brussels
    Blood 91:196-206
    ..b>CD28 is functionally involved in the recognition of B7 on target cells since IL-2/IL-12-activated NK cells derived from ..
  36. Contribution of the CD28 molecule to allergic and irritant-induced skin reactions in CD28 -/- mice
    S Kondo
    Division of Dermatology, Sunnybrook Health Science Center, University of Toronto, Canada
    J Immunol 157:4822-9
    The CD28 molecule is thought to be essential for the costimulatory signals and is required for mitogenic activation of T cells...
  37. CD28-deficient mice generate an impaired Th2 response to Schistosoma mansoni infection
    C L King
    Division of Geographic Medicine, Case Western Reserve University, Cleveland, OH 44106 4983, USA
    Eur J Immunol 26:2448-55
    Engagement of CD28 on T cells provides a co-stimulatory signal necessary for T cell activation and differentiation. Recent findings suggest that priming of T helper (Th)2 cells is more dependent on CD28 activation that Th1 cells...
  38. CD28/B7 regulation of Th1 and Th2 subsets in the development of autoimmune diabetes
    D J Lenschow
    Ben May Institute for Cancer Research, Department of Pathology, University of Chicago, Illinois 60637, USA
    Immunity 5:285-93
    b>CD28 ligation delivers a costimulatory signal important in T cell activation...
  39. Protection against lethal toxic shock by targeted disruption of the CD28 gene
    B Saha
    Naval Medical Research Institute, Bethesda, Maryland 20889, USA
    J Exp Med 183:2675-80
    ..Here we report that CD28-deficient mice (CD28-/-) are completely resistant to TSST-1-induced lethal TSS while CD28 (+/-) littermate mice ..
  40. Skin allograft rejection in CD28-deficient mice
    K Kawai
    Ontario Cancer Institute, Department of Medical Biophysics, University of Toronto, Canada
    Transplantation 61:352-5
    Costimulatory interactions between CD28 and the B7 family have been shown to augment T cell responses in general...
  41. Naive CD28-deficient T cells can initiate but not sustain an in vitro antigen-specific immune response
    P J Lucas
    Howard Hughes Medical Institute, Washington School of Medicine, St Louis, MO 63110, USA
    J Immunol 154:5757-68
    ..We have generated a CD28-deficient mouse that has been bred to a TCR transgenic (Tg) mouse to better study the function of CD28 during CD4+ ..
  42. In vivo blockade of CD28/CTLA4: B7/BB1 interaction with CTLA4-Ig reduces lethal murine graft-versus-host disease across the major histocompatibility complex barrier in mice
    B R Blazar
    Department of Pediatrics, University of Minnesota Hospital and Clinic, Minneapolis
    Blood 83:3815-25
    ..the in vivo infusion of recombinant, soluble CTLA4 fused with Ig heavy chains, as a surrogate ligand used to block CD28/CTLA4 T-cell costimulation, could prevent efficient T-cell activation and thereby reduce graft-versus-host disease (..
  43. Coordinate regulation of T cell activation by CD2 and CD28
    J M Green
    Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 164:3591-5
    ..However, the exact mechanism of costimulatory function is unknown. Mice lacking CD2 or CD28 show only mild deficits, demonstrating that neither protein is essential for T cell activation...
  44. The tyrosine kinase p56lck is essential in coxsackievirus B3-mediated heart disease
    P Liu
    Heart and Stroke Lewar Centre of Excellence in Cardiovascular Research, University of Toronto, University Health Network, 200 Elizabeth Street, Toronto, Ontario, Canada M5G 2C4
    Nat Med 6:429-34
    ..These data identify a previously unknown function of Src family kinases and indicate that p56lck is the essential host factor that controls the replication and pathogenicity of CVB3...
  45. Role of TNF receptor-associated factor 2 and p38 mitogen-activated protein kinase activation during 4-1BB-dependent immune response
    J L Cannons
    Department of Immunology, University of Toronto, Toronto, Ontario, Canada Howard Hughes Medical Institute and Rockefeller University, New York, NY 10021, USA
    J Immunol 165:6193-204
    ..Previous results showed that 4-1BB-mediated T cell costimulation is CD28-independent and involves recruitment of TNFR-associated factor 2 (TRAF2) and activation of the stress-activated ..
  46. Cutting edge: regulation of T cell activation threshold by CD28 costimulation through targeting Cbl-b for ubiquitination
    Jian Zhang
    Section of Molecular Medicine, Department of Orthopedic Surgery, Rush Medical College at Rush Presbyterian St Luke s Medical Center, Chicago, IL 60612, USA
    J Immunol 169:2236-40
    Optimal T cell activation requires signaling through the TCR and CD28 costimulatory receptor. CD28 costimulation is believed to set the threshold for T cell activation...
  47. Therapeutic effects of tumor reactive CD4+ cells generated from tumor-primed lymph nodes using anti-CD3/anti-CD28 monoclonal antibodies
    Qiao Li
    The Division of Surgical Oncology, University of Michigan Comprehensive Cancer Center, Ann Arbor 48109 0666, USA
    J Immunother 25:304-13
    ..in vitro and in vivo immune function analysis of tumor-draining lymph node (TDLN) cells after anti-CD3/anti-CD28 activation versus anti-CD3 activation alone in a murine tumor model...
  48. Impaired germinal centre formation and humoral immune response in the absence of CD28 and interleukin-4
    Rudolph Reiter
    Institute of Medical Microbiology, Immunology and Hygiene, Technical University of Munich, Munich, Germany
    Immunology 106:222-8
    ..dependent one via the T cell receptor, the second one is a costimulatory signal which can be delivered by the CD28 molecule after binding to CD80 (B7.1) or CD86 (B7.2)...
  49. Antibody-mediated control of persistent gamma-herpesvirus infection
    In Jeong Kim
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Immunol 168:3958-64
    ..In the current studies, CD28(-/-) mice were used to address the role of Abs in control of persistent murine gamma-herpesvirus-68 infection...
  50. Molecular mechanisms underlying differential contribution of CD28 versus non-CD28 costimulatory molecules to IL-2 promoter activation
    Xu Yu Zhou
    Department of Oncology, Osaka University Graduate School of Medicine, Osaka, Japan
    J Immunol 168:3847-54
    T cell costimulation via CD28 and other (non-CD28) costimulatory molecules induces comparable levels of [(3)H]TdR incorporation, but fundamentally differs in the contribution to IL-2 production...
  51. CD28(-/-) mice show defects in cellular and humoral immunity but are able to control infection with murine gammaherpesvirus 68
    Bong Joo Lee
    La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    J Virol 76:3049-53
    The role of CD28-dependent costimulatory interactions in the development and maintenance of antiviral immune responses was investigated in a mouse model of gammaherpesvirus infection...
  52. The development of a Th1-type response and resistance to Leishmania major infection in the absence of CD40-CD40L costimulation
    U M Padigel
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Immunol 167:5874-9
    ..major infection. In contrast, C57BL/6 mice deficient in CD28 develop a dominant Th1-type response and heal infection...
  53. Homeostatic expansion occurs independently of costimulatory signals
    M Prlic
    Department of Laboratory Medicine and Pathology, Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA
    J Immunol 167:5664-8
    ..that homeostatic expansion of CD4 and CD8 T cells occurs independently of costimulation signals mediated through CD28/B7, CD40L/CD40, or 4-1BB/4-1BBL interactions. Using DO11...
  54. Identification of the CD4(+) T cell as a major pathogenic factor in ischemic acute renal failure
    M J Burne
    Division of Nephrology, Hennepin County Medical Center, University of Minnesota, Minneapolis, Minnesota, USA
    J Clin Invest 108:1283-90
    ..In addition, adoptive transfers of CD4(+) T cells lacking either the costimulatory molecule CD28 or the ability to produce IFN-gamma were inadequate to restore injury phenotype...
  55. OX40 promotes Bcl-xL and Bcl-2 expression and is essential for long-term survival of CD4 T cells
    P R Rogers
    Division of Immunochemistry, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    Immunity 15:445-55
    ..We show that OX40 (CD134) is required with CD28 for the survival of CD4 T cells following antigen-driven expansion...
  56. Comparison of thymocyte development and cytokine production in CD7-deficient, CD28-deficient and CD7/CD28 double-deficient mice
    C S Heinly
    Division of Rheumatology, Allergy and Clinical Immunology, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Int Immunol 13:157-66
    CD7 and CD28 are Ig superfamily molecules expressed on thymocytes and mature T cells that share common signaling 0mechanisms and are co-mitogens for T cell activation...
  57. CD40 signaling replaces CD4+ lymphocytes and its blocking prevents chronic rejection of heart transplants
    M P Fischbein
    Department of Microbiology, Immunology, and Molecular Genetics, Division of Cardiothoracic Surgery, University of California Los Angeles School of Medicine, Los Angeles, CA 90095, USA
    J Immunol 165:7316-22
    ..The CD40 signaling pathway works independently of B7-CD28 costimulation, as indicated by the development of severe chronic rejection in CD28 knockout recipients...
  58. B7 requirements for primary and secondary protein- and polysaccharide-specific Ig isotype responses to Streptococcus pneumoniae
    Z Q Wu
    Departments of Pathology and Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    J Immunol 165:6840-8
    ..These studies demonstrate a critical, but variable, role for B7-dependent costimulation during an Ig response to an extracellular bacteria...
  59. Localization of growth arrest-specific genes on mouse chromosomes 1, 7, 8, 11, 13, and 16
    M P Colombo
    Division of Experimental Oncology D, Istituto Nazionali Tumori, Milano, Italy
    Mamm Genome 2:130-4
    ..The six genes are unlinked. Gas-1 maps to Chromosome (Chr) 13, Gas-2 to Chr 7, Gas-3 to Chr 11, Gas-4 to Chr 16, Gas-6 to Chr 8, and Gas-10 to Chr 1...