CD24

Summary

Gene Symbol: CD24
Description: CD24a antigen
Alias: Cd24, HSA, Ly-52, nectadrin, signal transducer CD24, M1/69-J11D heat stable antigen, R13-Ag, X62 heat stable antigen, cluster of differentiation 24, heat stable antigen, lymphocyte antigen 52
Species: mouse
Products:     CD24

Top Publications

  1. Wu Y, Zhou Q, Zheng P, Liu Y. CD28-independent induction of T helper cells and immunoglobulin class switches requires costimulation by the heat-stable antigen. J Exp Med. 1998;187:1151-6 pubmed
    ..test whether the CD28-independent induction of Ig class switches requires costimulation by the heat-stable antigen (HSA), we compared T helper cell induction and antibody response in mice deficient for either HSA, CD28, or both genes...
  2. Bai X, Liu J, Liu X, Guo Y, Cox K, Wen J, et al. The heat-stable antigen determines pathogenicity of self-reactive T cells in experimental autoimmune encephalomyelitis. J Clin Invest. 2000;105:1227-32 pubmed
    ..We report here that targeted mutation of the heat-stable antigen (HSA) abrogates development of EAE despite a complete lack of effect on induction of autoimmune T cells...
  3. Lu L, Chappel M, Humphries R, Osmond D. Regulation of cell survival during B lymphopoiesis: increased pre-B cell apoptosis in CD24-transgenic mouse bone marrow. Eur J Immunol. 2000;30:2686-91 pubmed
    b>CD24 (heat-stable antigen) is expressed in a developmentally regulated fashion by B cell precursors in mouse bone marrow (BM), but its role in B lymphopoiesis remains obscure...
  4. Salamone M, Rosselot C, Salamone G, Barboza M, Kado M, Fainboim L. Antibodies recognizing CD24 LAP epitope on human T cells enhance CD28 and IL-2 T cell proliferation. J Leukoc Biol. 2001;69:215-23 pubmed
    Membrane expression of the CD24 molecule on activated T lymphocytes is not elucidated fully...
  5. Kleene R, Yang H, Kutsche M, Schachner M. The neural recognition molecule L1 is a sialic acid-binding lectin for CD24, which induces promotion and inhibition of neurite outgrowth. J Biol Chem. 2001;276:21656-63 pubmed
    Among the recognition molecules that determine a neuron's interaction with other cells, L1 and CD24 have been suggested to cooperate with each other in neurite outgrowth and signal transduction...
  6. Aigner S, Ruppert M, Hubbe M, Sammar M, Sthoeger Z, Butcher E, et al. Heat stable antigen (mouse CD24) supports myeloid cell binding to endothelial and platelet P-selectin. Int Immunol. 1995;7:1557-65 pubmed
    ..Previously, we suggested that heat stable antigen (HSA/mouse CD24), an extensively glycosylated cell surface molecule on many mouse cells, is a ligand for P-..
  7. Kay R, Takei F, Humphries R. Expression cloning of a cDNA encoding M1/69-J11d heat-stable antigens. J Immunol. 1990;145:1952-9 pubmed
    ..These carbohydrates are likely to execute the functions of M1/69-J11d Ag, which could be specialized to each cell type as a consequence of differential glycosylation. ..
  8. Zhou Q, Rammohan K, Lin S, Robinson N, Li O, Liu X, et al. CD24 is a genetic modifier for risk and progression of multiple sclerosis. Proc Natl Acad Sci U S A. 2003;100:15041-6 pubmed
    ..We have reported that CD24 is required for the pathogenicity of autoreactive T cells in experimental autoimmune encephalomyelitis, the mouse ..
  9. Wang Y, Zhu L, McHugh R, Sell K, Selvaraj P. Expression of heat-stable antigen on tumor cells provides co-stimulation for tumor-specific T cell proliferation and cytotoxicity in mice. Eur J Immunol. 1995;25:1163-7 pubmed
    Heat-stable antigen (HSA/J11d/possibly homologous to CD24), a cell adhesion molecule capable of providing a co-stimulatory signal for T cell proliferation, is expressed on B cells, activated T cells, monocytes, granulocytes, Langerhans ..

More Information

Publications89

  1. Liu Y, Wenger R, Zhao M, Nielsen P. Distinct costimulatory molecules are required for the induction of effector and memory cytotoxic T lymphocytes. J Exp Med. 1997;185:251-62 pubmed
    ..To address this issue, we have produced mice with targeted mutations of either the heat-stable antigen (HSA), or both HSA and CD28...
  2. Bai X, Li O, Zhou Q, Zhang H, Joshi P, Zheng X, et al. CD24 controls expansion and persistence of autoreactive T cells in the central nervous system during experimental autoimmune encephalomyelitis. J Exp Med. 2004;200:447-58 pubmed
    ..We have demonstrated previously that expression by the host cells of the heat-stable antigen (CD24), which was recently identified as a genetic modifier for MS, is essential for their susceptibility to EAE...
  3. Belvindrah R, Rougon G, Chazal G. Increased neurogenesis in adult mCD24-deficient mice. J Neurosci. 2002;22:3594-607 pubmed
    ..Altogether, our data suggest that mCD24 regulates negatively cell proliferation in zones of secondary neurogenesis. ..
  4. Hubbe M, Altevogt P. Heat-stable antigen/CD24 on mouse T lymphocytes: evidence for a costimulatory function. Eur J Immunol. 1994;24:731-7 pubmed
    Heat-stable antigen (HSA)/mouse CD24 (formerly termed Nectadrin) is a membrane glycoprotein with an unusual structure consisting of a small protein core and extensive glycosylation...
  5. Nielsen P, Lorenz B, Muller A, Wenger R, Brombacher F, Simon M, et al. Altered erythrocytes and a leaky block in B-cell development in CD24/HSA-deficient mice. Blood. 1997;89:1058-67 pubmed
    The heat stable antigen (HSA, or murine CD24) is a glycosyl phosphatidylinositol-linked surface glycoprotein expressed on immature cells of most, if not all, major hematopoietic lineages, as well as in developing neural and epithelial ..
  6. Calaora V, Chazal G, Nielsen P, Rougon G, Moreau H. mCD24 expression in the developing mouse brain and in zones of secondary neurogenesis in the adult. Neuroscience. 1996;73:581-94 pubmed
    ..Its spatiotemporal expression, both during development and in the adult, is compatible with a role for this glycoprotein in cell surface recognition and in signalling events occurring during neuronal migration and axonal growth. ..
  7. Liu Y, Jones B, Aruffo A, Sullivan K, Linsley P, Janeway C. Heat-stable antigen is a costimulatory molecule for CD4 T cell growth. J Exp Med. 1992;175:437-45 pubmed
    ..Gene transfer experiments directly demonstrate that this protein has costimulatory activity. Thus, heat-stable antigen meets the criteria for a costimulator of T cell clonal expansion. ..
  8. Zhou Q, Wu Y, Nielsen P, Liu Y. Homotypic interaction of the heat-stable antigen is not responsible for its co-stimulatory activity for T cell clonal expansion. Eur J Immunol. 1997;27:2524-8 pubmed
    The heat-stable antigen (HSA) is an important co-stimulatory molecule on antigen-presenting cells (APC). However, the receptor on T cells that receives the co-stimulatory signal from HSA has not been identified...
  9. Liu Y, Jones B, Brady W, Janeway C, Linsley P, Linley P. Co-stimulation of murine CD4 T cell growth: cooperation between B7 and heat-stable antigen. Eur J Immunol. 1992;22:2855-9 pubmed
    ..In mice, the heat-stable antigen (HSA) has also been shown to act as a co-stimulator for T cell growth...
  10. Li O, Zheng P, Liu Y. CD24 expression on T cells is required for optimal T cell proliferation in lymphopenic host. J Exp Med. 2004;200:1083-9 pubmed
    ..Here, we report that T cells from mice with a targeted mutation of CD24 have a remarkably reduced rate of proliferation when adoptively transferred into syngeneic lymphopenic hosts...
  11. Chen G, Tang J, Zheng P, Liu Y. CD24 and Siglec-10 selectively repress tissue damage-induced immune responses. Science. 2009;323:1722-5 pubmed publisher
    ..We report that CD24-deficient mice exhibit increased susceptibility to danger- but not pathogen-associated molecular patterns...
  12. Wenger R, Ayane M, Bose R, Kohler G, Nielsen P. The genes for a mouse hematopoietic differentiation marker called the heat-stable antigen. Eur J Immunol. 1991;21:1039-46 pubmed
    ..by several antibodies against the murine hematopoietic differentiation marker called heat-stable antigen (HSA)...
  13. Zarn J, Zimmermann S, Pass M, Waibel R, Stahel R. Association of CD24 with the kinase c-fgr in a small cell lung cancer cell line and with the kinase lyn in an erythroleukemia cell line. Biochem Biophys Res Commun. 1996;225:384-91 pubmed
    Human CD24 is a highly glycosylated glycosylphosphatidylinositol-linked (GPI-linked) cell surface protein. GPI-linked proteins are involved in signal transduction mediated by members of the protein tyrosine kinase (PTK) family...
  14. Wenger R, Kopf M, Nitschke L, Lamers M, Kohler G, Nielsen P. B-cell maturation in chimaeric mice deficient for the heat stable antigen (HSA/mouse CD24). Transgenic Res. 1995;4:173-83 pubmed
    The murine differentiation marker heat stable antigen (HSA) is a GPI-anchored surface glycoprotein showing strong expression on immature B- and T-lymphocytes and gradually reduced expression during maturation...
  15. Enk A, Katz S. Heat-stable antigen is an important costimulatory molecule on epidermal Langerhans' cells. J Immunol. 1994;152:3264-70 pubmed
    Heat-stable antigen (HSA), expressed by activated B cells, has been described as a costimulatory molecule for CD4+ T cells...
  16. Hahne M, Wenger R, Vestweber D, Nielsen P. The heat-stable antigen can alter very late antigen 4-mediated adhesion. J Exp Med. 1994;179:1391-5 pubmed
    ..We have analyzed whether heat-stable antigen (HSA), a marker for immature leukocytes, is involved in such cell adhesion phenomena...
  17. Liu W, Monahan K, Pfefferle A, Shimamura T, Sorrentino J, Chan K, et al. LKB1/STK11 inactivation leads to expansion of a prometastatic tumor subpopulation in melanoma. Cancer Cell. 2012;21:751-64 pubmed publisher
    ..phosphorylation of the SRC family kinase (SFK) YES, increased expression of WNT target genes, and expansion of a CD24(+) cell population, which showed increased metastatic behavior in vitro and in vivo relative to isogenic CD24(..
  18. Wang L, Wildt K, Zhu J, Zhang X, Feigenbaum L, Tessarollo L, et al. Distinct functions for the transcription factors GATA-3 and ThPOK during intrathymic differentiation of CD4(+) T cells. Nat Immunol. 2008;9:1122-30 pubmed publisher
    ..We propose that GATA-3 acts as a specification factor for the CD4(+) lineage 'upstream' of the ThPOK-controlled CD4(+) commitment checkpoint. ..
  19. Chen C, He Z, Sai P, Faridi A, Aziz A, Kalavar M, et al. Inhibition of human CD24 binding to platelet-bound P-selectin by monoclonal antibody. Proc West Pharmacol Soc. 2004;47:28-9 pubmed
    ..b>CD24, one of the mucin-type ligands of P-selectin, is expressed in various adenocarcinomas and may mediate the ..
  20. Gerth A, Lin L, Peng S. T-bet regulates T-independent IgG2a class switching. Int Immunol. 2003;15:937-44 pubmed
    ..T-bet-deficient B cells therefore represent a novel paradigm by which to investigate the regulation of humoral immune responses. ..
  21. Li O, Chang X, Zhang H, Kocak E, Ding C, Zheng P, et al. Massive and destructive T cell response to homeostatic cue in CD24-deficient lymphopenic hosts. J Exp Med. 2006;203:1713-20 pubmed
    ..In this study, we report that in lymphopenic CD24-deficient mice, T cells launch a massive proliferation that results in the rapid death of the recipient mice...
  22. Kilger G, Needham L, Nielsen P, Clements J, Vestweber D, Holzmann B. Differential regulation of alpha 4 integrin-dependent binding to domains 1 and 4 of vascular cell adhesion molecule-1. J Biol Chem. 1995;270:5979-84 pubmed
    ..Instead, the activity level of integrin alpha 4 beta 1 for domain 1 binding was regulated by CD24 expression. Binding to seven domain VCAM-1 was not altered significantly by beta 1 and beta 7 subunits or CD24...
  23. Bretz N, Salnikov A, Doberstein K, Garbi N, Kloess V, Joumaa S, et al. Lack of CD24 expression in mice reduces the number of leukocytes in the colon. Immunol Lett. 2014;161:140-8 pubmed publisher
    b>CD24 is an extensively glycosylated membrane protein that is linked to the membrane via a glycosyl-phosphatidylinositol (GPI)-anchor. In mice, CD24 is expressed by hematopoietic and non-hematopoietic cells...
  24. Cremers N, Deugnier M, Sleeman J. Loss of CD24 expression promotes ductal branching in the murine mammary gland. Cell Mol Life Sci. 2010;67:2311-22 pubmed publisher
    b>CD24 is expressed on mammary stem cells and is used as a marker for their isolation, yet its function in the mammary gland still needs to be examined...
  25. Taguchi T, Kiyokawa N, Mimori K, Suzuki T, Sekino T, Nakajima H, et al. Pre-B cell antigen receptor-mediated signal inhibits CD24-induced apoptosis in human pre-B cells. J Immunol. 2003;170:252-60 pubmed
    ..In this study, we extend our previous observation and report that CD24 also mediated apoptosis in human precursor-B acute lymphoblastic leukemia cell lines in the pro-B and pre-B stages ..
  26. Schievenbusch S, Sauer E, Curth H, Schulte S, Demir M, Toex U, et al. Neighbor of Punc E 11: expression pattern of the new hepatic stem/progenitor cell marker during murine liver development. Stem Cells Dev. 2012;21:2656-66 pubmed publisher
    ..activated stem/progenitor (oval) cells clearly coexpress Nope together with the common markers A6, EpCAM, and CD24 in the 3,5-diethoxycarbonyl-1,4-dihydrocollidine mouse model...
  27. Burgos Ojeda D, Wu R, McLean K, Chen Y, Talpaz M, Yoon E, et al. CD24+ Ovarian Cancer Cells Are Enriched for Cancer-Initiating Cells and Dependent on JAK2 Signaling for Growth and Metastasis. Mol Cancer Ther. 2015;14:1717-27 pubmed publisher
    ..Cell lines derived from these murine tumors express numerous putative stem cell markers, including CD24, CD44, CD90, CD117, CD133, and ALDH...
  28. Hough M, Chappel M, Sauvageau G, Takei F, Kay R, Humphries R. Reduction of early B lymphocyte precursors in transgenic mice overexpressing the murine heat-stable antigen. J Immunol. 1996;156:479-88 pubmed
    To study the role of the murine heat-stable Ag (HSA) in lymphocyte maturation, we generated transgenic mice in which the HSA cDNA was under the transcriptional control of the TCR V beta promoter and Ig mu enhancer...
  29. Jonk L, de Jonge M, Vervaart J, Wissink S, Kruijer W. Isolation and developmental expression of retinoic-acid-induced genes. Dev Biol. 1994;161:604-14 pubmed
    ..In addition to the previously recognized genes encoding vimentin, heat stable antigen, neural cadherin, Hox-B2, F52/MacMARCKS, thymosin beta 4b, and the murine homolog of COUP-TF1, we ..
  30. Suzuki T, Kiyokawa N, Taguchi T, Sekino T, Katagiri Y, Fujimoto J. CD24 induces apoptosis in human B cells via the glycolipid-enriched membrane domains/rafts-mediated signaling system. J Immunol. 2001;166:5567-77 pubmed
    The glycosylphosphatidylinositol-anchored CD24 protein is a B cell differentiation Ag that is expressed on mature resting B cells but disappears upon Ag stimulation...
  31. Kadmon G, Imhof B, Altevogt P, Schachner M. Adhesive hierarchy involving the cell adhesion molecules L1, CD24, and alpha 6 integrin in murine neuroblastoma N2A cells. Biochem Biophys Res Commun. 1995;214:94-101 pubmed
    ..CD24 (nectadrin) antibodies did not affect the aggregation of isolated or confluent cells but stimulated the aggregation of ..
  32. Li W, Ling H, You W, Liu H, Sun Q, Zhou M, et al. Elevated cerebral cortical CD24 levels in patients and mice with traumatic brain injury: a potential negative role in nuclear factor ?b/inflammatory factor pathway. Mol Neurobiol. 2014;49:187-98 pubmed publisher
    ..However, the specific mechanisms remain largely unknown, as is whether CD24, known as an important regulator in the non-infectious inflammatory response, plays a role in secondary brain ..
  33. Hitsumoto Y, Nakano A, Ohnishi H, Hamada F, Saheki S, Takeuchi N. Purification of the murine heat-stable antigen from erythrocytes. Biochem Biophys Res Commun. 1992;187:773-7 pubmed
    ..The amino acid sequence of the affinity-purified R13-Ag corresponded to that predicted from the cDNA for the murine heat-stable antigen. It was revealed that the actual heat-stable antigen was composed of 27 amino acids. ..
  34. Carlyle J, Jamieson A, Gasser S, Clingan C, Arase H, Raulet D. Missing self-recognition of Ocil/Clr-b by inhibitory NKR-P1 natural killer cell receptors. Proc Natl Acad Sci U S A. 2004;101:3527-32 pubmed
    ..Remarkably, Ocil/Clr-b is frequently down-regulated on mouse tumor cell lines, indicating a role for this receptor-ligand system in a new form of "missing self-recognition" of tumor cells. ..
  35. Zhou Q, Toivola D, Feng N, Greenberg H, Franke W, Omary M. Keratin 20 helps maintain intermediate filament organization in intestinal epithelia. Mol Biol Cell. 2003;14:2959-71 pubmed
    ..Our data suggest the presence of unique regulatory domains for pancreatic and gastric K20 expression and support a significant role for K20 in maintaining keratin filaments in intestinal epithelia. ..
  36. Zhang X, Liu J, Shi Y, Reid H, Boyd R, Khattabi M, et al. CD24 on thymic APCs regulates negative selection of myelin antigen-specific T lymphocytes. Eur J Immunol. 2012;42:924-35 pubmed publisher
    ..In this regard, we previously reported that CD24, a GPI-anchored glycoprotein, is required for thymic generation of autoreactive T lymphocytes...
  37. Lubeseder Martellato C, Hidalgo Sastre A, Hartmann C, Alexandrow K, Kamyabi Moghaddam Z, Sipos B, et al. Membranous CD24 drives the epithelial phenotype of pancreatic cancer. Oncotarget. 2016;7:49156-49168 pubmed publisher
    Surface CD24 has previously been described, together with CD44 and ESA, for the characterization of putative cancer stem cells in pancreatic ductal adenocarcinoma (PDAC), the most fatal of all solid tumors...
  38. Shapira S, Ben Amotz O, Sher O, Kazanov D, Mashiah J, Kraus S, et al. Delayed Wound Healing in Heat Stable Antigen (HSA/CD24)-Deficient Mice. PLoS ONE. 2015;10:e0139787 pubmed publisher
    ..An excisional model of wound healing was used and delayed wound healing was studied in genetically modified heat stable antigen (HSA/CD24)-deficient mice (HSA-/-) compared to wild-type (WT) mice...
  39. Carl J, Liu J, Joshi P, El Omrani H, Yin L, Zheng X, et al. Autoreactive T cells escape clonal deletion in the thymus by a CD24-dependent pathway. J Immunol. 2008;181:320-8 pubmed
    ..It is largely unknown how these T cells escape clonal deletion. In this study, we report that CD24 deficiency caused deletion of autoreactive T cells that normally escape negative selection...
  40. Thaxton J, Liu B, Zheng P, Liu Y, Li Z. Deletion of CD24 impairs development of heat shock protein gp96-driven autoimmune disease through expansion of myeloid-derived suppressor cells. J Immunol. 2014;192:5679-86 pubmed publisher
    b>CD24 binds to and suppresses inflammation triggered by danger-associated molecular patterns such as heat shock proteins (HSPs) and high-mobility group box 1. Paradoxically, CD24 has been shown to enhance autoimmune disease...
  41. Lund Johansen F, Olweus J, Symington F, Arli A, Thompson J, Vilella R, et al. Activation of human monocytes and granulocytes by monoclonal antibodies to glycosylphosphatidylinositol-anchored antigens. Eur J Immunol. 1993;23:2782-91 pubmed
    ..In granulocytes primed with 200 mM N-formyl-Met-Leu-Phe (FMLP), cross-linking of cell-bound anti-CD16, -CD24, -CD59 and -CD67 led to calcium fluxes and activation of the oxidative burst...
  42. Bensimon J, Biard D, Paget V, Goislard M, Morel Altmeyer S, Konge J, et al. Forced extinction of CD24 stem-like breast cancer marker alone promotes radiation resistance through the control of oxidative stress. Mol Carcinog. 2016;55:245-54 pubmed publisher
    Along with CD44, CD24 is a key marker of breast cancer stem cells (CSCs), frequently defined by CD24(-)/CD44(+) labeling...
  43. Fischer G, Majdic O, Gadd S, Knapp W. Signal transduction in lymphocytic and myeloid cells via CD24, a new member of phosphoinositol-anchored membrane molecules. J Immunol. 1990;144:638-41 pubmed
    The CD24 Ag is present on human B cells from the earliest stages of B lineage development and is lost on terminal B cell maturation to plasma cells. This Ag is also expressed on mature forms of granulocytes...
  44. Kim T, Gorski S, Hahn S, Murphy K, Braciale T. Distinct dendritic cell subsets dictate the fate decision between effector and memory CD8(+) T cell differentiation by a CD24-dependent mechanism. Immunity. 2014;40:400-13 pubmed publisher
    ..CD103(+) RDCs expressed CD24 at an elevated level, contributing to the propensity of this DC subpopulation to support CD8(+) Teff cell ..
  45. Gracz A, Ramalingam S, Magness S. Sox9 expression marks a subset of CD24-expressing small intestine epithelial stem cells that form organoids in vitro. Am J Physiol Gastrointest Liver Physiol. 2010;298:G590-600 pubmed publisher
    ..A prospective search revealed that CD24 is expressed in the Sox9(EGFPlo) population and marks IESCs that form organoids in culture...
  46. Scheurer S, Rybak J, Rösli C, Neri D, Elia G. Modulation of gene expression by hypoxia in human umbilical cord vein endothelial cells: A transcriptomic and proteomic study. Proteomics. 2004;4:1737-60 pubmed
    ..g., CXCR4, claudin 3, CD24, tetranectin, Del-1, procollagen lysyl hydroxylase 1 and 2) which are transcriptionally upregulated in hypoxic ..
  47. Shakiba N, White C, Lipsitz Y, Yachie Kinoshita A, Tonge P, Hussein S, et al. CD24 tracks divergent pluripotent states in mouse and human cells. Nat Commun. 2015;6:7329 pubmed publisher
    ..Here we use cell surface proteomics to interrogate mouse cell reprogramming dynamics and discover CD24 as a marker that tracks the emergence of reprogramming-responsive cells, while enabling the analysis and enrichment ..
  48. Ruppert M, Aigner S, Hubbe M, Yagita H, Altevogt P. The L1 adhesion molecule is a cellular ligand for VLA-5. J Cell Biol. 1995;131:1881-91 pubmed
    ..Mouse ESb-MP cells expressing VLA-5 and L1 could be induced to aggregate in the presence of specific mAbs to CD24 (heat-stable antigen), a highly and heterogeneously glycosylated glycophosphatidylinositol-linked differentiation ..
  49. Lieberoth A, Splittstoesser F, Katagihallimath N, Jakovcevski I, Loers G, Ranscht B, et al. Lewis(x) and alpha2,3-sialyl glycans and their receptors TAG-1, Contactin, and L1 mediate CD24-dependent neurite outgrowth. J Neurosci. 2009;29:6677-90 pubmed publisher
    ..outgrowth of cerebellar or dorsal root ganglion neurons, respectively, induced by the mucin-type adhesion molecule CD24 depends on alpha2,3-linked sialic acid and Lewis(x) present on glia-specific CD24 glycoforms...
  50. Rostoker R, Ben Shmuel S, Rashed R, Shen Orr Z, LeRoith D. CD24 cell surface expression in Mvt1 mammary cancer cells serves as a biomarker for sensitivity to anti-IGF1R therapy. Breast Cancer Res. 2016;18:51 pubmed publisher
    ..Based on CD24 cell surface expression, control and IGF1R-knockdown (IGF1R-KD) cells were FACS sorted into CD24(-) and CD24(+) ..
  51. Duckworth C, Clyde D, Pritchard D. CD24 is expressed in gastric parietal cells and regulates apoptosis and the response to Helicobacter felis infection in the murine stomach. Am J Physiol Gastrointest Liver Physiol. 2012;303:G915-26 pubmed publisher
    b>CD24 is expressed in the putative stem cells within several tissues and is overexpressed in gastric and colonic adenocarcinomas...
  52. Wang L, Liu R, Ye P, Wong C, Chen G, Zhou P, et al. Intracellular CD24 disrupts the ARF-NPM interaction and enables mutational and viral oncogene-mediated p53 inactivation. Nat Commun. 2015;6:5909 pubmed publisher
    b>CD24 is overexpressed in nearly 70% human cancers, whereas TP53 is the most frequently mutated tumour-suppressor gene that functions in a context-dependent manner...
  53. Nakamichi R, Ito Y, Inui M, Onizuka N, Kayama T, Kataoka K, et al. Mohawk promotes the maintenance and regeneration of the outer annulus fibrosus of intervertebral discs. Nat Commun. 2016;7:12503 pubmed publisher
    ..Mesenchymal stem cells overexpressing Mkx promote functional AF regeneration in a mouse AF defect model, with abundant collagen fibril formation. Our results indicate a therapeutic strategy for AF regeneration. ..
  54. Avivi Arber L, Avivi D, Perez M, Arber N, Shapira S. Impaired bone healing at tooth extraction sites in CD24-deficient mice: A pilot study. PLoS ONE. 2018;13:e0191665 pubmed publisher
    ..bone healing at maxillary first molar extraction sites, and test the hypothesis that bone healing is impaired in CD24-knockout mice as compared with wild-type C57BL/6J mice...
  55. Jia J, Dai M, Zhuang Y. E proteins are required to activate germline transcription of the TCR Vbeta8.2 gene. Eur J Immunol. 2008;38:2806-20 pubmed publisher
    ..2 germline transcription. We provide evidence that IL-7R expression is only partially controlled by E2A, suggesting a role for E2A in driving Vbeta8.2 germline transcription independent of IL-7R activation. ..
  56. Bleckmann C, Geyer H, Lieberoth A, Splittstoesser F, Liu Y, Feizi T, et al. O-glycosylation pattern of CD24 from mouse brain. Biol Chem. 2009;390:627-45 pubmed publisher
    The cell adhesion molecule CD24 is a highly glycosylated glycoprotein that plays important roles in the central nervous system, the immune system and in tumor biology...
  57. Krauss K, Altevogt P. Integrin leukocyte function-associated antigen-1-mediated cell binding can be activated by clustering of membrane rafts. J Biol Chem. 1999;274:36921-7 pubmed
    ..induced by clustering of membrane rafts using antibodies to the glycosylphophatidylinositol-anchored molecule CD24 or cholera toxin (CTx)...
  58. Shaw L, Johnson P, Kimber S. Gene expression profiling of the developing mouse kidney and embryo. In Vitro Cell Dev Biol Anim. 2010;46:155-65 pubmed publisher
    ..Use of a combination of highly expressed and negative markers may aid in the identification and removal of non-renal cells from heterogeneous populations of differentiating stem cells. ..
  59. Mirzadeh Z, Han Y, Soriano Navarro M, Garcia Verdugo J, Alvarez Buylla A. Cilia organize ependymal planar polarity. J Neurosci. 2010;30:2600-10 pubmed publisher
    ..These results suggest that ependymal planar cell polarity is a multistep process initially organized by primary cilia in radial glia and then refined by motile cilia in ependymal cells. ..
  60. Berga Bolaños R, Drews Elger K, Aramburu J, Lopez Rodriguez C. NFAT5 regulates T lymphocyte homeostasis and CD24-dependent T cell expansion under pathologic hypernatremia. J Immunol. 2010;185:6624-35 pubmed publisher
    ..By analyzing surface receptors whose expression might be affected in NFAT5-deficient cells, we identified CD24 as a novel NFAT5 target induced by hypertonicity both in vitro and in vivo, and required to sustain T cell ..
  61. Sammar M, Gulbins E, Hilbert K, Lang F, Altevogt P. Mouse CD24 as a signaling molecule for integrin-mediated cell binding: functional and physical association with src-kinases. Biochem Biophys Res Commun. 1997;234:330-4 pubmed
    b>CD24 is a differentiation antigen expressed by murine hematopoietic and neural cells which is linked to the membrane via a glycosylphosphatidylinositol (GPI) anchor...
  62. Overdevest J, Knubel K, Duex J, Thomas S, Nitz M, Harding M, et al. CD24 expression is important in male urothelial tumorigenesis and metastasis in mice and is androgen regulated. Proc Natl Acad Sci U S A. 2012;109:E3588-96 pubmed publisher
    Overexpression of CD24, a glycosyl phosphatidylinositol-linked sialoglycoprotein, is associated with poor outcome in urothelial carcinoma and contributes to experimental tumor growth and metastasis...
  63. Naumov I, Zilberberg A, Shapira S, Avivi D, Kazanov D, Rosin Arbesfeld R, et al. CD24 knockout prevents colorectal cancer in chemically induced colon carcinogenesis and in APC(Min)/CD24 double knockout transgenic mice. Int J Cancer. 2014;135:1048-59 pubmed publisher
    Increased expression of CD24 is seen in a large variety of solid tumors, including up to 90% of gastrointestinal (GI) tumors...
  64. Fairbridge N, Southall T, Ayre D, Komatsu Y, Raquet P, Brown R, et al. Loss of CD24 in Mice Leads to Metabolic Dysfunctions and a Reduction in White Adipocyte Tissue. PLoS ONE. 2015;10:e0141966 pubmed publisher
    b>CD24 is a glycophosphatidylinositol (GPI)-linked cell surface receptor that is involved in regulating the survival or differentiation of several different cell types...
  65. Cram D, McIntosh A, Oxbrow L, Johnston A, Deaizpurua H. Differential mRNA display analysis of two related but functionally distinct rat insulinoma (RIN) cell lines: identification of CD24 and its expression in the developing pancreas. Differentiation. 1999;64:237-46 pubmed
    ..sequences were determined for these cDNAs and database searches identified one known gene that encoded heat stable antigen CD24...
  66. Lesourne R, Zvezdova E, Song K, El Khoury D, Uehara S, Barr V, et al. Interchangeability of Themis1 and Themis2 in thymocyte development reveals two related proteins with conserved molecular function. J Immunol. 2012;189:1154-61 pubmed publisher
    ..These results suggest that conserved molecular features of the Themis1 and Themis2 proteins are important for their biological activity and predict that Themis1 and Themis2 may perform similar functions in T and B cells, respectively. ..
  67. Hermans M, Deenen G, De Boer N, Bo W, Kroese F, Opstelten D. Expression of HIS50 Ag: a rat homologue of mouse heat-stable antigen and human CD24 on B lymphoid cells in the rat. Immunology. 1997;90:14-22 pubmed
    ..mAb) HIS50 was cloned and shown to be homologous to cDNA encoding murine heat-stable antigen (HSA) and human CD24. Here we show that, like CD24 and HSA, at least part of HIS50 Ag is inserted into the plasma membrane by a ..
  68. Belluoccio D, Etich J, Rosenbaum S, Frie C, Grskovic I, Stermann J, et al. Sorting of growth plate chondrocytes allows the isolation and characterization of cells of a defined differentiation status. J Bone Miner Res. 2010;25:1267-81 pubmed publisher
    ..This approach provides a novel platform to study cartilage development and characterize mouse growth plate chondrocytes to reveal unique cellular phenotypes of the distinct subpopulations within the growth plate. ..
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    ..These studies demonstrate that SOX2 may meet the requirements of a universal neural stem cell marker and provides a means to identify cells which fulfill the basic criteria of a stem cell: self-renewal and multipotent differentiation. ..
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    ..These interactions of GPA and other glycoproteins may contribute to maintaining the physical strength of the erythrocyte membrane. ..
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    ..This is the first demonstration indicating that isolated cardiac hypothyroidism causes cardiac dysfunction in the absence of changes in the adrenergic or peripheral vascular system. ..
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    ..cytometric analysis of three distinct populations derived from human embryonic stem cells: (1) CD15(+)/CD29(HI)/CD24(LO) surface antigen expression defined neural stem cells; (2) CD15(-)/CD29(HI)/CD24(LO) revealed neural crest-like ..
  74. Longley R, Smith C, Fortin A, Berghout J, McMorran B, Burgio G, et al. Host resistance to malaria: using mouse models to explore the host response. Mamm Genome. 2011;22:32-42 pubmed publisher
    ..Perhaps the lessons learned from the natural variation in both the human populations and experimental mouse models of infection may pave the way for novel resistance-proof antimalarials. ..
  75. Cuevas E, Rybak Wolf A, Rohde A, Nguyen D, Wulczyn F. Lin41/Trim71 is essential for mouse development and specifically expressed in postnatal ependymal cells of the brain. Front Cell Dev Biol. 2015;3:20 pubmed publisher
    ..Our results reveal that terminally differentiated ependymal cells express Lin41, a gene to date associated with self-renewing stem cells. ..
  76. Hitsumoto Y, Song D, Okada M, Hamada F, Saheki S, Takeuchi N. Enhancement of CD3-mediated thymocyte apoptosis by the cross-linkage of heat-stable antigen. Immunology. 1996;89:200-4 pubmed
    Heat-stable antigen (HSA) is a murine differentiating antigen that is expressed on both CD4-CD8- double-negative and CD4+CD8+ double-positive thymocytes but not CD4+ or CD8+ single-positive thymocytes...
  77. Keller S, Rupp C, Stoeck A, Runz S, Fogel M, Lugert S, et al. CD24 is a marker of exosomes secreted into urine and amniotic fluid. Kidney Int. 2007;72:1095-102 pubmed
    ..These vesicles are thought to play a role in cell-cell interactions. CD24 is a small but extensively glycosylated protein linked to the cell surface by means of a glycosyl-..
  78. Liu Y, Chen G, Zheng P. CD24-Siglec G/10 discriminates danger- from pathogen-associated molecular patterns. Trends Immunol. 2009;30:557-61 pubmed publisher
    ..We demonstrated recently that the host response to DAMP is controlled by a DAMP-CD24-Siglec axis. Here we propose a key role for the CD24-Siglec pathway in discriminating between DAMPs and PAMPs.
  79. King J, von Furstenberg R, Smith B, McNaughton K, Galanko J, Henning S. CD24 can be used to isolate Lgr5+ putative colonic epithelial stem cells in mice. Am J Physiol Gastrointest Liver Physiol. 2012;303:G443-52 pubmed publisher
    A growing body of evidence has implicated CD24, a cell-surface protein, as a marker of colorectal cancer stem cells and target for antitumor therapy, although its presence in normal colonic epithelium has not been fully characterized...
  80. Yang G, Ross D, Kuang W, Brown P, Weigel R. Combining SSH and cDNA microarrays for rapid identification of differentially expressed genes. Nucleic Acids Res. 1999;27:1517-23 pubmed
    ..Sequence analysis identified four of these clones as cytokeratin 19, GATA-3, CD24 and glutathione-S-transferase mu-3...