Cd22

Summary

Gene Symbol: Cd22
Description: CD22 antigen
Alias: A530093D23, Lyb-8, Lyb8, B-cell receptor CD22, B-lymphocyte cell adhesion molecule, BL-CAM, T-cell surface antigen Leu-14, sialic acid-binding Ig-like lectin 2, siglec-2
Species: mouse
Products:     Cd22

Top Publications

  1. Mary C, Laporte C, Parzy D, Santiago M, Stefani F, Lajaunias F, et al. Dysregulated expression of the Cd22 gene as a result of a short interspersed nucleotide element insertion in Cd22a lupus-prone mice. J Immunol. 2000;165:2987-96 pubmed
    The Cd22 gene encodes a B cell-specific adhesion molecule that modulates B cell Ag receptor-mediated signal transduction, and is allelic to a lupus-susceptibility locus in New Zealand White (NZW) mice...
  2. Tedder T, Poe J, Haas K. CD22: a multifunctional receptor that regulates B lymphocyte survival and signal transduction. Adv Immunol. 2005;88:1-50 pubmed
    Recent advances in the study of CD22 indicate a complex role for this transmembrane glycoprotein member of the immunoglobulin superfamily in the regulation of B lymphocyte survival and proliferation...
  3. Otipoby K, Draves K, Clark E. CD22 regulates B cell receptor-mediated signals via two domains that independently recruit Grb2 and SHP-1. J Biol Chem. 2001;276:44315-22 pubmed
    ..b>CD22 is a B cell-restricted coreceptor that gets rapidly tyrosyl-phosphorylated and recruits various signaling molecules ..
  4. Yanaba K, Bouaziz J, Matsushita T, Tsubata T, Tedder T. The development and function of regulatory B cells expressing IL-10 (B10 cells) requires antigen receptor diversity and TLR signals. J Immunol. 2009;182:7459-72 pubmed publisher
    ..Thereby, both adaptive and innate signals regulate B10 cell development, maturation, CD5 expression, and competence for IL-10 production. ..
  5. Ferry H, Crockford T, Cockford T, Silver K, Rust N, Goodnow C, et al. Analysis of Lyn/CD22 double-deficient B cells in vivo demonstrates Lyn- and CD22-independent pathways affecting BCR regulation and B cell survival. Eur J Immunol. 2005;35:3655-63 pubmed
    ..These co-receptors have been broadly classified into inhibitory and enhancing groups, yet some, such as CD22, may have dual effects...
  6. Nitschke L, Carsetti R, Ocker B, Kohler G, Lamers M. CD22 is a negative regulator of B-cell receptor signalling. Curr Biol. 1997;7:133-43 pubmed
    ..b>CD22 is a BCR-associated transmembrane protein, the cytoplasmic tail of which contains three immunoreceptor tyrosine-..
  7. Cyster J, Goodnow C. Tuning antigen receptor signaling by CD22: integrating cues from antigens and the microenvironment. Immunity. 1997;6:509-17 pubmed
  8. Cornall R, Cyster J, Hibbs M, Dunn A, Otipoby K, Clark E, et al. Polygenic autoimmune traits: Lyn, CD22, and SHP-1 are limiting elements of a biochemical pathway regulating BCR signaling and selection. Immunity. 1998;8:497-508 pubmed
    ..demonstrating that negative regulation of the BCR is a complex quantitative trait in which Lyn, the coreceptor CD22, and the tyrosine phosphatase SHP-1 are each limiting elements...
  9. O Keefe T, Williams G, Batista F, Neuberger M. Deficiency in CD22, a B cell-specific inhibitory receptor, is sufficient to predispose to development of high affinity autoantibodies. J Exp Med. 1999;189:1307-13 pubmed
    b>CD22 is a B cell-specific transmembrane glycoprotein that acts to dampen signals generated through the B cell antigen receptor (BCR): B cells from CD22-deficient mice give increased Ca2+ fluxes on BCR ligation...

More Information

Publications80

  1. O Keefe T, Williams G, Davies S, Neuberger M. Hyperresponsive B cells in CD22-deficient mice. Science. 1996;274:798-801 pubmed
    b>CD22 is a surface glycoprotein of B lymphocytes that is rapidly phosphorylated on cytoplasmic tyrosines after antigen receptor cross-linking...
  2. Onodera T, Poe J, Tedder T, Tsubata T. CD22 regulates time course of both B cell division and antibody response. J Immunol. 2008;180:907-13 pubmed
    ..In this study, we demonstrate that B cells deficient in the inhibitory coreceptor CD22 undergo accelerated cell division after Ag stimulation, resulting in rapid generation of plasma cells and Ab ..
  3. Waisman A, Kraus M, Seagal J, Ghosh S, Melamed D, Song J, et al. IgG1 B cell receptor signaling is inhibited by CD22 and promotes the development of B cells whose survival is less dependent on Ig alpha/beta. J Exp Med. 2007;204:747-58 pubmed
    ..showed an enhanced Ca(2+) response upon B cell receptor cross-linking, which was not due to a lack of inhibition by CD22. The enhanced Ca(2+) response was also observed in mature B cells that had been switched from IgM to IgG1 ..
  4. Smith K, Tarlinton D, Doody G, Hibbs M, Fearon D. Inhibition of the B cell by CD22: a requirement for Lyn. J Exp Med. 1998;187:807-11 pubmed
    Mice in which the Lyn, Cd22, or Shp-1 gene has been disrupted have hyperactive B cells and autoantibodies...
  5. Grewal P, Boton M, Ramirez K, Collins B, Saito A, Green R, et al. ST6Gal-I restrains CD22-dependent antigen receptor endocytosis and Shp-1 recruitment in normal and pathogenic immune signaling. Mol Cell Biol. 2006;26:4970-81 pubmed
    The ST6Gal-I sialyltransferase produces Siglec ligands for the B-cell-specific CD22 lectin and sustains humoral immune responses...
  6. Lajaunias F, Nitschke L, Moll T, Martinez Soria E, Semac I, Chicheportiche Y, et al. Differentially regulated expression and function of CD22 in activated B-1 and B-2 lymphocytes. J Immunol. 2002;168:6078-83 pubmed
    b>CD22 is a B cell-restricted transmembrane protein that apparently controls signal transduction thresholds initiated through the B cell Ag receptor (BCR) in response to Ag...
  7. Sato S, Miller A, Inaoki M, Bock C, Jansen P, Tang M, et al. CD22 is both a positive and negative regulator of B lymphocyte antigen receptor signal transduction: altered signaling in CD22-deficient mice. Immunity. 1996;5:551-62 pubmed
    B cell activation following antigen receptor cross-linking can be augmented in vitro by ligation of cell surface CD22, which associates with the SHP1 protein tyrosine phosphatase...
  8. Otipoby K, Andersson K, Draves K, Klaus S, Farr A, Kerner J, et al. CD22 regulates thymus-independent responses and the lifespan of B cells. Nature. 1996;384:634-7 pubmed
    The B-lymphocyte-restricted glycoprotein CD22 is expressed on mature IgM+IgD+ B cells, and is capable of binding to ligands on T and B cells...
  9. Poe J, Smith S, Haas K, Yanaba K, Tsubata T, Matsushita T, et al. Amplified B lymphocyte CD40 signaling drives regulatory B10 cell expansion in mice. PLoS ONE. 2011;6:e22464 pubmed publisher
    ..b>CD22 deficient (CD22(-/-)) mice also produce autoAbs, and importantly, their B cells are hyper-proliferative following ..
  10. Smith S, Haas K, Poe J, Yanaba K, Ward C, Migone T, et al. B-cell homeostasis requires complementary CD22 and BLyS/BR3 survival signals. Int Immunol. 2010;22:681-91 pubmed publisher
    ..plays a key role in regulating peripheral B-cell homeostasis. CD22 also promotes peripheral B-cell survival through ligand-dependent mechanisms...
  11. Fujimoto M, Bradney A, Poe J, Steeber D, Tedder T. Modulation of B lymphocyte antigen receptor signal transduction by a CD19/CD22 regulatory loop. Immunity. 1999;11:191-200 pubmed
    CD19 and CD22 are B lymphocyte cell-surface molecules that positively and negatively regulate antigen receptor signal transduction, respectively...
  12. Samardzic T, Marinkovic D, Danzer C, Gerlach J, Nitschke L, Wirth T. Reduction of marginal zone B cells in CD22-deficient mice. Eur J Immunol. 2002;32:561-7 pubmed
    b>CD22 is a B cell-specific member of the immunoglobulin superfamily and binds to sialic acid. CD22 inhibits B cell receptor signaling. Mice deficient for CD22 show a largely normal B cell development...
  13. Poe J, Fujimoto Y, Hasegawa M, Haas K, Miller A, Sanford I, et al. CD22 regulates B lymphocyte function in vivo through both ligand-dependent and ligand-independent mechanisms. Nat Immunol. 2004;5:1078-87 pubmed
    The interaction of CD22 with alpha2,6-linked sialic acid ligands has been widely proposed to regulate B lymphocyte function and migration...
  14. Horikawa K, Martin S, Pogue S, Silver K, Peng K, Takatsu K, et al. Enhancement and suppression of signaling by the conserved tail of IgG memory-type B cell antigen receptors. J Exp Med. 2007;204:759-69 pubmed
    ..Biochemical analysis and crosses to CD22-deficient mice established that IgG tail enhancement of calcium and antibody responses, as well as marginal zone B ..
  15. Law C, Aruffo A, Chandran K, Doty R, Clark E. Ig domains 1 and 2 of murine CD22 constitute the ligand-binding domain and bind multiple sialylated ligands expressed on B and T cells. J Immunol. 1995;155:3368-76 pubmed
    Baby hamster kidney cells transfected with murine CD22 (mCD22) mediate adhesion to B- and T-lineage cells...
  16. Poe J, Fujimoto M, Jansen P, Miller A, Tedder T. CD22 forms a quaternary complex with SHIP, Grb2, and Shc. A pathway for regulation of B lymphocyte antigen receptor-induced calcium flux. J Biol Chem. 2000;275:17420-7 pubmed
    b>CD22 is a cell surface molecule that regulates signal transduction in B lymphocytes...
  17. Jin L, McLean P, Neel B, Wortis H. Sialic acid binding domains of CD22 are required for negative regulation of B cell receptor signaling. J Exp Med. 2002;195:1199-205 pubmed
    b>CD22, a negative regulator of B cell antigen receptor signaling, binds glycoconjugates terminating in alpha2, 6 sialic acid. The physiological ligand(s) for CD22 remain unknown...
  18. Haas K, Sen S, Sanford I, Miller A, Poe J, Tedder T. CD22 ligand binding regulates normal and malignant B lymphocyte survival in vivo. J Immunol. 2006;177:3063-73 pubmed
    The CD22 extracellular domain regulates B lymphocyte function by interacting with alpha2,6-linked sialic acid-bearing ligands...
  19. Ghosh S, Bandulet C, Nitschke L. Regulation of B cell development and B cell signalling by CD22 and its ligands alpha2,6-linked sialic acids. Int Immunol. 2006;18:603-11 pubmed
    b>CD22 is an inhibitory co-receptor of B cell receptor (BCR)-mediated signalling which binds specifically to glycan ligands containing alpha2,6-linked sialic acids. This interaction modulates the CD22 activity by an unknown mechanism...
  20. Collins B, Smith B, Bengtson P, Paulson J. Ablation of CD22 in ligand-deficient mice restores B cell receptor signaling. Nat Immunol. 2006;7:199-206 pubmed
    b>CD22 is a negative regulator of B cell signaling, an activity modulated by its interaction with glycan ligands containing alpha2-6-linked sialic acids...
  21. Kelm S, Pelz A, Schauer R, Filbin M, Tang S, de Bellard M, et al. Sialoadhesin, myelin-associated glycoprotein and CD22 define a new family of sialic acid-dependent adhesion molecules of the immunoglobulin superfamily. Curr Biol. 1994;4:965-72 pubmed
    ..Apart from the selectins, the only well-characterized vertebrate sialic acid-dependent adhesion molecules are CD22 and sialoadhesin; CD22 is a member of the immunoglobulin superfamily that is expressed by B lymphocytes and ..
  22. Chen J, McLean P, Neel B, Okunade G, Shull G, Wortis H. CD22 attenuates calcium signaling by potentiating plasma membrane calcium-ATPase activity. Nat Immunol. 2004;5:651-7 pubmed
    ..b>CD22, a B cell surface protein, inhibits this signal through mechanisms that have been obscure...
  23. Collins B, Blixt O, DeSieno A, Bovin N, Marth J, Paulson J. Masking of CD22 by cis ligands does not prevent redistribution of CD22 to sites of cell contact. Proc Natl Acad Sci U S A. 2004;101:6104-9 pubmed
    b>CD22, a negative regulator of B cell signaling, is a member of the siglec family that binds to alpha2-6-linked sialic acids on glycoproteins...
  24. Poe J, Haas K, Uchida J, Lee Y, Fujimoto M, Tedder T. Severely impaired B lymphocyte proliferation, survival, and induction of the c-Myc:Cullin 1 ubiquitin ligase pathway resulting from CD22 deficiency on the C57BL/6 genetic background. J Immunol. 2004;172:2100-10 pubmed
    Understanding the molecular mechanisms through which CD22 regulates B lymphocyte homeostasis, signal transduction, and tolerance is critical to defining normal B cell function and understanding the role of CD22 in autoimmunity...
  25. Alborzian Deh Sheikh A, Akatsu C, Imamura A, Abdu Allah H, Takematsu H, Ando H, et al. Proximity labeling of cis-ligands of CD22/Siglec-2 reveals stepwise ?2,6 sialic acid-dependent and -independent interactions. Biochem Biophys Res Commun. 2018;495:854-859 pubmed publisher
    ..Cis-ligands are most extensively studied in CD22 (also known as Siglec-2), an inhibitory B lymphocyte receptor specifically recognizing ?2,6 sialic acids...
  26. Schwab I, Seeling M, Biburger M, Aschermann S, Nitschke L, Nimmerjahn F. B cells and CD22 are dispensable for the immediate antiinflammatory activity of intravenous immunoglobulins in vivo. Eur J Immunol. 2012;42:3302-9 pubmed publisher
    ..More recently, B cells and the sialic acid-binding protein CD22 were suggested to be involved in this IVIg-dependent immunomodulatory pathway...
  27. Poe J, Kountikov E, Lykken J, Natarajan A, Marchuk D, Tedder T. EndoU is a novel regulator of AICD during peripheral B cell selection. J Exp Med. 2014;211:57-69 pubmed publisher
    ..B cell survival and tolerance to self-antigens (Ags), a gene modifier screen was performed with B cells from CD22-deficient C57BL/6 (CD22(-/-[B6])) mice that undergo activation-induced cell death (AICD) and fail to up-regulate c-..
  28. Torres R, Law C, Santos Argumedo L, Kirkham P, Grabstein K, Parkhouse R, et al. Identification and characterization of the murine homologue of CD22, a B lymphocyte-restricted adhesion molecule. J Immunol. 1992;149:2641-9 pubmed
    The human B lymphocyte-specific Ag, CD22, is a cell adhesion molecule expressed on the surface during a narrow window of B cell development, coincident with surface IgD...
  29. Horikawa M, Weimer E, DiLillo D, Venturi G, Spolski R, Leonard W, et al. Regulatory B cell (B10 Cell) expansion during Listeria infection governs innate and cellular immune responses in mice. J Immunol. 2013;190:1158-68 pubmed publisher
    ..92-97% lower in B10 cell-deficient CD19(-/-) mice, in mice depleted of mature B cells, and in mice treated with CD22 mAb to preferentially deplete B10 cells before infection...
  30. Blasioli J, Goodnow C. Lyn/CD22/SHP-1 and their importance in autoimmunity. Curr Dir Autoimmun. 2002;5:151-60 pubmed
  31. Tsubata T, Onodera T. [Regulation of B lymphocyte signaling by Siglecs]. Tanpakushitsu Kakusan Koso. 2008;53:1636-40 pubmed
  32. Arnold C, Pirie E, Dosenovic P, McInerney G, Xia Y, Wang N, et al. A forward genetic screen reveals roles for Nfkbid, Zeb1, and Ruvbl2 in humoral immunity. Proc Natl Acad Sci U S A. 2012;109:12286-93 pubmed publisher
    ..All of the mutations identified to date directly affect lymphocyte development or function; none have an exclusive effect on cells of the innate immune system. ..
  33. Ostrakhovitch E, Wang Y, Li S. SAP binds to CD22 and regulates B cell inhibitory signaling and calcium flux. Cell Signal. 2009;21:540-50 pubmed publisher
    ..in mouse splenic B cells, is inducibly expressed in the human BJAB cells, and co-localizes and interacts with CD22. We also show that SAP binding to the inhibitory immunoreceptor CD22 regulates calcium mobilization in B cells...
  34. Gasparrini F, Feest C, Bruckbauer A, Mattila P, Müller J, Nitschke L, et al. Nanoscale organization and dynamics of the siglec CD22 cooperate with the cytoskeleton in restraining BCR signalling. EMBO J. 2016;35:258-80 pubmed publisher
    ..Using super-resolution microscopy and single-particle tracking, we show how the negative coreceptor CD22 works with the cortical cytoskeleton in restraining BCR signalling...
  35. Gerlach J, Ghosh S, Jumaa H, Reth M, Wienands J, Chan A, et al. B cell defects in SLP65/BLNK-deficient mice can be partially corrected by the absence of CD22, an inhibitory coreceptor for BCR signaling. Eur J Immunol. 2003;33:3418-26 pubmed
    b>CD22 is an inhibitory coreceptor for B cell receptor (BCR) signaling. The inhibition is most likely mediated by activation of SHP-1...
  36. Satterthwaite A, Willis F, Kanchanastit P, Fruman D, Cantley L, Helgason C, et al. A sensitized genetic system for the analysis of murine B lymphocyte signal transduction pathways dependent on Bruton's tyrosine kinase. Proc Natl Acad Sci U S A. 2000;97:6687-92 pubmed
    ..Haploinsufficiency or complete deficiency of protein kinase C beta, Fyn, CD22, Galphaq, or Galpha11 had no detectable effect on the function of Btk(lo) B cells...
  37. Sathish J, Walters J, Luo J, Johnson K, Leroy F, Brennan P, et al. CD22 is a functional ligand for SH2 domain-containing protein-tyrosine phosphatase-1 in primary T cells. J Biol Chem. 2004;279:47783-91 pubmed
    ..Here we present a combination of biochemical and yeast genetic analyses indicating CD22 to be a T cell ligand for the SHP-1 SH2 domains...
  38. Yarkoni Y, Fischel R, Kat I, Yachimovich Cohen N, Eilat D. Peripheral B cell receptor editing may promote the production of high-affinity autoantibodies in CD22-deficient mice. Eur J Immunol. 2006;36:2755-67 pubmed
    b>CD22-deficient mice are characterized by B cell hyperactivity and autoimmunity...
  39. Macauley M, Paulson J. Siglecs induce tolerance to cell surface antigens by BIM-dependent deletion of the antigen-reactive B cells. J Immunol. 2014;193:4312-21 pubmed publisher
    ..Based on recent findings showing that the B cell siglecs, CD22 and Siglec-G, can promote tolerance to Ags presented on the same surface as their ligands, we speculated that the B ..
  40. COUGHLIN S, Noviski M, Mueller J, Chuwonpad A, Raschke W, Weiss A, et al. An extracatalytic function of CD45 in B cells is mediated by CD22. Proc Natl Acad Sci U S A. 2015;112:E6515-24 pubmed publisher
    ..B-cell antigen receptor (BCR) signaling through modulation of the function of the inhibitory coreceptor CD22. This finding has important implications for understanding how naïve B cells maintain tonic BCR signaling while ..
  41. Amano H, Amano E, Moll T, Marinkovic D, Ibnou Zekri N, Martinez Soria E, et al. The Yaa mutation promoting murine lupus causes defective development of marginal zone B cells. J Immunol. 2003;170:2293-301 pubmed
    ..Furthermore, a comparative analysis with mice deficient in CD22 or expressing an IgM anti-trinitrophenyl/DNA transgene suggests that the hyperreactive phenotype of Yaa B cells, as ..
  42. Fujimoto M, Kuwano Y, Watanabe R, Asashima N, Nakashima H, Yoshitake S, et al. B cell antigen receptor and CD40 differentially regulate CD22 tyrosine phosphorylation. J Immunol. 2006;176:873-9 pubmed
    ..b>CD22 is a B cell-specific cell surface protein that contains multiple ITIMs in the cytoplasmic tail, and critically ..
  43. Moll T, Nitschke L, Carroll M, Ravetch J, Izui S. A critical role for Fc gamma RIIB in the induction of rheumatoid factors. J Immunol. 2004;173:4724-8 pubmed
    ..In contrast to FcgammaRIIB, the deficiency in another BCR negative regulator, CD22, was unable to promote RF and anti-DNA autoimmune responses in B6 mice...
  44. Sindhava V, Tuna H, Gachuki B, DiLillo D, Avdiushko M, Onami T, et al. Bone marrow dendritic cell-mediated regulation of TLR and B cell receptor signaling in B cells. J Immunol. 2012;189:3355-67 pubmed
    ..Optimal suppression of B cell activation by iBMDCs required cell contact via the CD22 receptor on B cells...
  45. Zhu C, Sato M, Yanagisawa T, Fujimoto M, Adachi T, Tsubata T. Novel binding site for Src homology 2-containing protein-tyrosine phosphatase-1 in CD22 activated by B lymphocyte stimulation with antigen. J Biol Chem. 2008;283:1653-9 pubmed
    b>CD22, a B lymphocyte membrane glycoprotein, contains immunoreceptor tyrosine-based inhibition motifs (ITIMs) in the cytoplasmic region and recruits Src homology 2-containing protein-tyrosine phosphatase-1 (SHP-1) to the phosphorylated ..
  46. Wen T, Mingler M, Blanchard C, Wahl B, Pabst O, Rothenberg M. The pan-B cell marker CD22 is expressed on gastrointestinal eosinophils and negatively regulates tissue eosinophilia. J Immunol. 2012;188:1075-82 pubmed publisher
    b>CD22 is currently recognized as a B cell-specific Siglec and has been exploited therapeutically with humanized anti-CD22 mAb having been used against B cell leukemia...
  47. Gjertsson I, Nitschke L, Tarkowski A. The role of B cell CD22 expression in Staphylococcus aureus arthritis and sepsis. Microbes Infect. 2004;6:377-82 pubmed
    ..aureus infections. CD22 is a B-cell-specific inhibitory receptor binding to alpha2,6-linked sialic acids, and deficiency in CD22 leads to a ..
  48. O Reilly M, Tian H, Paulson J. CD22 is a recycling receptor that can shuttle cargo between the cell surface and endosomal compartments of B cells. J Immunol. 2011;186:1554-63 pubmed publisher
    b>CD22 is a member of the sialic acid-binding Ig-like lectin (Siglec) family that is known to be a regulator of B cell signaling...
  49. Haas K, Johnson K, Phipps J, Do C. CD22 Promotes B-1b Cell Responses to T Cell-Independent Type 2 Antigens. J Immunol. 2018;200:1671-1681 pubmed publisher
    b>CD22 (Siglec-2) is a critical regulator of B cell activation and survival...
  50. Roes J, Rajewsky K. Immunoglobulin D (IgD)-deficient mice reveal an auxiliary receptor function for IgD in antigen-mediated recruitment of B cells. J Exp Med. 1993;177:45-55 pubmed
    ..conventional and CD5-positive (B1) B cells are present in normal numbers, and the expression of the surface markers CD22 and CD23 in the compartment of conventional B cells indicates acquisition of a mature phenotype...
  51. Santiago M, Mary C, Parzy D, Jacquet C, Montagutelli X, Parkhouse R, et al. Linkage of a major quantitative trait locus to Yaa gene-induced lupus-like nephritis in (NZW x C57BL/6)F1 mice. Eur J Immunol. 1998;28:4257-67 pubmed
    ..Our study thus provides a model to dissect the complex genetic interactions that result in manifestations of murine lupus-like disease. ..
  52. Mills D, Stolpa J, Cambier J. Cognate B cell signaling via MHC class II: differential regulation of B cell antigen receptor and MHC class II/Ig-alpha beta signaling by CD22. J Immunol. 2004;172:195-201 pubmed
    ..In this study, we demonstrate that CD22, an inhibitory BCR coreceptor, neither associates with nor functions in MHC class II/Ig-alphabeta signaling...
  53. Bhattacharyya S, Deb J, Patra A, Thuy Pham D, Chen W, Vaeth M, et al. NFATc1 affects mouse splenic B cell function by controlling the calcineurin--NFAT signaling network. J Exp Med. 2011;208:823-39 pubmed publisher
    ..By affecting CD22, Rcan1, CnA, and NFATc1/?A expression, NFATc1 controls the Ca(2+)-dependent Cn-NFAT signaling network and, thereby, ..
  54. Duong B, Tian H, Ota T, Completo G, Han S, VELA J, et al. Decoration of T-independent antigen with ligands for CD22 and Siglec-G can suppress immunity and induce B cell tolerance in vivo. J Exp Med. 2010;207:173-87 pubmed publisher
    ..Two siglecs, CD22 and Siglec-G, contributed to tolerance induction, preventing plasma cell differentiation or survival...
  55. Macauley M, Kawasaki N, Peng W, Wang S, He Y, Arlian B, et al. Unmasking of CD22 Co-receptor on Germinal Center B-cells Occurs by Alternative Mechanisms in Mouse and Man. J Biol Chem. 2015;290:30066-77 pubmed publisher
    b>CD22 is an inhibitory B-cell co-receptor whose function is modulated by sialic acid (Sia)-bearing glycan ligands. Glycan remodeling in the germinal center (GC) alters CD22 ligands, with as yet no ascribed biological consequence...
  56. Layseca Espinosa E, Korniotis S, Montandon R, Gras C, Bouillié M, Gonzalez Amaro R, et al. CCL22-producing CD8?- myeloid dendritic cells mediate regulatory T cell recruitment in response to G-CSF treatment. J Immunol. 2013;191:2266-72 pubmed publisher
    ..These data assign a key role to CD8?(-) DCs and CCL22 in Treg recruitment in the protection of NOD mice against type 1 diabetes following the treatment with G-CSF. ..
  57. Naito Matsui Y, Takada S, Kano Y, Iyoda T, Sugai M, Shimizu A, et al. Functional evaluation of activation-dependent alterations in the sialoglycan composition of T cells. J Biol Chem. 2014;289:1564-79 pubmed publisher
    ..Expression of sialoadhesin and Siglec-F ligands increased, and that of CD22 ligands decreased...
  58. Nitschke L, Floyd H, Ferguson D, Crocker P. Identification of CD22 ligands on bone marrow sinusoidal endothelium implicated in CD22-dependent homing of recirculating B cells. J Exp Med. 1999;189:1513-8 pubmed
    b>CD22 is a B cell-specific transmembrane protein known to function as a negative regulator of B cell signaling. It has also been implicated in cell adhesion through recognition of alpha2,6-linked sialic acids on glycans of target cells...
  59. Gross A, Lyandres J, Panigrahi A, Prak E, DeFranco A. Developmental acquisition of the Lyn-CD22-SHP-1 inhibitory pathway promotes B cell tolerance. J Immunol. 2009;182:5382-92 pubmed publisher
    ..The effects of CD22 deficiency on BCR signaling were very similar in B cells at different stages of maturation...
  60. Santos L, Draves K, Boton M, Grewal P, Marth J, Clark E. Dendritic cell-dependent inhibition of B cell proliferation requires CD22. J Immunol. 2008;180:4561-9 pubmed
    ..This inhibition is overcome by treatment with BAFF and is dependent on the BCR coreceptor CD22; however, it is not dependent on expression of the CD22 glycan ligand(s) produced by ST6Gal-I sialyltransferase...
  61. Yu J, Sawada T, Adachi T, Gao X, Takematsu H, Kozutsumi Y, et al. Synthetic glycan ligand excludes CD22 from antigen receptor-containing lipid rafts. Biochem Biophys Res Commun. 2007;360:759-64 pubmed
    b>CD22/Siglec-2 is a B cell membrane-bound lectin that recognizes glycan ligands containing alpha2,6-linked sialic acid, and negatively regulates signaling through the B cell antigen receptor (BCR)...
  62. John B, Herrin B, Raman C, Wang Y, Bobbitt K, Brody B, et al. The B cell coreceptor CD22 associates with AP50, a clathrin-coated pit adapter protein, via tyrosine-dependent interaction. J Immunol. 2003;170:3534-43 pubmed
    The B cell coreceptor CD22 plays an important role in regulating signal transduction via the B cell Ag receptor. Studies have shown that surface expression of CD22 can be modulated in response to binding of ligand (i.e., mAb)...
  63. Qian Y, Santiago C, Borrero M, Tedder T, Clarke S. Lupus-specific antiribonucleoprotein B cell tolerance in nonautoimmune mice is maintained by differentiation to B-1 and governed by B cell receptor signaling thresholds. J Immunol. 2001;166:2412-9 pubmed
    ..by the strength of B cell receptor signaling, since manipulations of the B cell receptor coreceptors CD19 and CD22 affect anti-Sm B cell differentiation and autoantibody production...
  64. Erickson L, Tygrett L, Bhatia S, Grabstein K, Waldschmidt T. Differential expression of CD22 (Lyb8) on murine B cells. Int Immunol. 1996;8:1121-9 pubmed
    Previous studies have established the distribution, biochemistry and functional attributes of human CD22, a B cell-restricted glycoprotein...
  65. Andersson K, Draves K, Magaletti D, Fujioka S, Holmes K, Law C, et al. Characterization of the expression and gene promoter of CD22 in murine B cells. Eur J Immunol. 1996;26:3170-8 pubmed
    b>CD22 is a B cell-restricted surface molecule which may play an important role in interactions between B cells and other cells and in regulating signals through the B cell receptor (BCR) complex...
  66. Lajaunias F, Ibnou Zekri N, Fossati Jimack L, Chicheportiche Y, Parkhouse R, Mary C, et al. Polymorphisms in the Cd22 gene of inbred mouse strains. Immunogenetics. 1999;49:991-5 pubmed
  67. Ma D, Suthar M, Kasahara S, Gale M, Clark E. CD22 is required for protection against West Nile virus Infection. J Virol. 2013;87:3361-75 pubmed publisher
    ..b>CD22 (Siglec-2) is expressed on B cells and regulates B cell receptor signaling, cell survival, proliferation, and ..
  68. Nitschke L, Lajaunias F, Moll T, Ho L, Martinez Soria E, Kikuchi S, et al. Expression of aberrant forms of CD22 on B lymphocytes in Cd22a lupus-prone mice affects ligand binding. Int Immunol. 2006;18:59-68 pubmed
    b>CD22 functions primarily as a negative regulator of B-cell receptor signaling. The Cd22a allele has been proposed as a candidate allele for murine systemic lupus erythematosus...
  69. von Poser Klein C, Flechsig E, Hoffmann T, Schwarz P, Harms H, Bujdoso R, et al. Alteration of B-cell subsets enhances neuroinvasion in mouse scrapie infection. J Virol. 2008;82:3791-5 pubmed publisher
    ..This appears to be due to an alteration of the follicular dendritic cell (FDC) network within the lymphoid tissue, thereby reducing the distance between FDCs and adjacent nerve fibers that mediate prion neuroinvasion. ..
  70. Odaka M, Hasegawa M, Hamaguchi Y, Ishiura N, Kumada S, Matsushita T, et al. Autoantibody-mediated regulation of B cell responses by functional anti-CD22 autoantibodies in patients with systemic sclerosis. Clin Exp Immunol. 2010;159:176-84 pubmed publisher
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