Gene Symbol: Cd1d1
Description: CD1d1 antigen
Alias: AI747460, CD1.1, Cd1a, Cd1d, Ly-38, antigen-presenting glycoprotein CD1d1, T-cell surface glycoprotein CD1d1
Species: mouse
Products:     Cd1d1

Top Publications

  1. Tyznik A, Tupin E, Nagarajan N, Her M, Benedict C, Kronenberg M. Cutting edge: the mechanism of invariant NKT cell responses to viral danger signals. J Immunol. 2008;181:4452-6 pubmed
    ..This requires TLR9 signaling and IL-12 secretion by the activated DCs, but it does not require CD1d expression. iNKT cells also produce IFN-gamma in response to mouse CMV infection...
  2. Chen Y, Chiu N, Mandal M, Wang N, Wang C. Impaired NK1+ T cell development and early IL-4 production in CD1-deficient mice. Immunity. 1997;6:459-67 pubmed
    ..The rapid effector cytokine secretion of these T cells suggests that CD1 educates adaptive immune cells to subserve functions of innate immunity. ..
  3. Jahng A, Maricic I, Aguilera C, Cardell S, Halder R, Kumar V. Prevention of autoimmunity by targeting a distinct, noninvariant CD1d-reactive T cell population reactive to sulfatide. J Exp Med. 2004;199:947-57 pubmed
    ..It is not yet known whether CD1d-restricted T cells reactive to myelin-derived lipids are present in the CNS and might be targeted to influence the ..
  4. Wang B, Geng Y, Wang C. CD1-restricted NK T cells protect nonobese diabetic mice from developing diabetes. J Exp Med. 2001;194:313-20 pubmed
    NK T cells are a unique subset of T cells that recognize lipid antigens presented by CD1d. After activation, NK T cells promptly produce large amounts of cytokines, which may modulate the upcoming immune responses...
  5. Matsuda J, Gapin L, Sidobre S, Kieper W, Tan J, Ceredig R, et al. Homeostasis of V alpha 14i NKT cells. Nat Immunol. 2002;3:966-74 pubmed
    b>CD1d-reactive natural killer T (NKT) cells with an invariant V alpha 14 rearrangement (V alpha 14i) are a distinct subset of T lymphocytes that likely have important immune-regulatory functions...
  6. Blomqvist M, Rhost S, Teneberg S, Löfbom L, Osterbye T, Brigl M, et al. Multiple tissue-specific isoforms of sulfatide activate CD1d-restricted type II NKT cells. Eur J Immunol. 2009;39:1726-35 pubmed publisher
    The glycosphingolipid sulfatide (SO(3)-3Galbeta1Cer) is a demonstrated ligand for a subset of CD1d-restricted NKT cells, which could regulate experimental autoimmune encephalomyelitis, a murine model for multiple sclerosis, as well as ..
  7. Fiedler T, Walter W, Reichert T, Maeurer M. Regulation of CD1d expression by murine tumor cells: escape from immunosurveillance or alternate target molecules?. Int J Cancer. 2002;98:389-97 pubmed
    ..e., the group II CD1 antigens, which are split into CD1D1 and CD1d2...
  8. Bai L, Constantinides M, Thomas S, Reboulet R, Meng F, Koentgen F, et al. Distinct APCs explain the cytokine bias of ?-galactosylceramide variants in vivo. J Immunol. 2012;188:3053-61 pubmed publisher
    ..Using cd1d1(fl/fl) mice, we demonstrated that distinct APC types explained the cytokine bias in vivo...
  9. Pichavant M, Goya S, Meyer E, Johnston R, Kim H, Matangkasombut P, et al. Ozone exposure in a mouse model induces airway hyperreactivity that requires the presence of natural killer T cells and IL-17. J Exp Med. 2008;205:385-93 pubmed publisher
    ..Surprisingly, NKT cell-deficient (CD1d(-/-) and Jalpha18(-/-)) mice failed to develop ozone-induced AHR...

More Information


  1. Tupin E, Nicoletti A, Elhage R, Rudling M, Ljunggren H, Hansson G, et al. CD1d-dependent activation of NKT cells aggravates atherosclerosis. J Exp Med. 2004;199:417-22 pubmed
    ..Natural killer T (NKT) cells can recognize lipid antigens presented by CD1 molecules. We have explored the role of CD1d-restricted NKT cells in atherosclerosis by using apolipoprotein E-deficient (apoE-/-) mice, a hypercholesterolemic ..
  2. Walunas T, Wang B, Wang C, Leiden J. Cutting edge: the Ets1 transcription factor is required for the development of NK T cells in mice. J Immunol. 2000;164:2857-60 pubmed
    ..We conclude that Ets1 defines a novel transcriptional regulatory pathway that is required for the development of both the NK and NK T cell lineages. ..
  3. Wiethe C, Schiemann M, Busch D, Haeberle L, Kopf M, Schuler G, et al. Interdependency of MHC class II/self-peptide and CD1d/self-glycolipid presentation by TNF-matured dendritic cells for protection from autoimmunity. J Immunol. 2007;178:4908-16 pubmed
    ..the nature of the DC directing T and NKT cell activation and polarization as well as the role of the respective CD1d Ags presented is still unclear...
  4. Bezbradica J, Gordy L, Stanic A, Dragovic S, Hill T, Hawiger J, et al. Granulocyte-macrophage colony-stimulating factor regulates effector differentiation of invariant natural killer T cells during thymic ontogeny. Immunity. 2006;25:487-97 pubmed
    ..Thus, we ascribe a unique function to Csf-2, which regulates iNKT cell effector differentiation during development by a mechanism that renders them competent for cytokine secretion. ..
  5. De Santo C, Salio M, Masri S, Lee L, Dong T, Speak A, et al. Invariant NKT cells reduce the immunosuppressive activity of influenza A virus-induced myeloid-derived suppressor cells in mice and humans. J Clin Invest. 2008;118:4036-48 pubmed publisher
    ..The crosstalk between iNKT and MDSCs was CD1d- and CD40-dependent...
  6. Parekh V, Singh A, Wilson M, Olivares Villagómez D, Bezbradica J, Inazawa H, et al. Quantitative and qualitative differences in the in vivo response of NKT cells to distinct alpha- and beta-anomeric glycolipids. J Immunol. 2004;173:3693-706 pubmed
    ..unique subset of immunoregulatory T cells that recognize glycolipid Ags presented by the MHC class I-like molecule CD1d. Because of their immunoregulatory properties, NKT cells are attractive targets for the development of ..
  7. Zhou D, Cantu C, Sagiv Y, Schrantz N, Kulkarni A, Qi X, et al. Editing of CD1d-bound lipid antigens by endosomal lipid transfer proteins. Science. 2004;303:523-7 pubmed prosaposin, the precursor to a family of endosomal lipid transfer proteins (LTP), exhibit specific defects in CD1d-mediated antigen presentation and lack Valpha14 NKT cells...
  8. Hong C, Lee H, Park Y, Shin J, Jung S, Kim H, et al. Regulation of secondary antigen-specific CD8(+) T-cell responses by natural killer T cells. Cancer Res. 2009;69:4301-8 pubmed publisher
    ..Taken together, our findings strongly emphasize the importance of NKT cells in secondary CD8(+) T-cell immune responses. ..
  9. Yue S, Nowak M, Shaulov Kask A, Wang R, Yue D, Balk S, et al. Direct CD1d-mediated stimulation of APC IL-12 production and protective immune response to virus infection in vivo. J Immunol. 2010;184:268-76 pubmed publisher
    b>CD1d-restricted NKT cells rapidly stimulate innate and adaptive immunity through production of Th1 and/or Th2 cytokines and induction of CD1d(+) APC maturation...
  10. Kim P, Pai S, Brigl M, Besra G, Gumperz J, Ho I. GATA-3 regulates the development and function of invariant NKT cells. J Immunol. 2006;177:6650-9 pubmed
    ..In addition, GATA-3 is also required for survival, activation, and effector functions of this unique population of T cells. Our data also reveal a previously unidentified peripheral maturation step that is GATA-3 dependent. ..
  11. Pasquier B, Yin L, Fondaneche M, Relouzat F, Bloch Queyrat C, Lambert N, et al. Defective NKT cell development in mice and humans lacking the adapter SAP, the X-linked lymphoproliferative syndrome gene product. J Exp Med. 2005;201:695-701 pubmed
    ..They also identify for the first time a defect in NKT cells associated with a human primary immunodeficiency, revealing a potential role of NKT cells in the immune response to EBV. ..
  12. Lee Y, Holzapfel K, Zhu J, Jameson S, Hogquist K. Steady-state production of IL-4 modulates immunity in mouse strains and is determined by lineage diversity of iNKT cells. Nat Immunol. 2013;14:1146-54 pubmed publisher
    ..Thus, iNKT cell-derived IL-4 altered immunological properties under normal steady-state conditions. ..
  13. Lee I, van den Elzen P, Tan R, Priatel J. NKT cells are required for complete Freund's adjuvant-mediated protection from autoimmune diabetes. J Immunol. 2011;187:2898-904 pubmed publisher
    ..In this study, we report that CFA-mediated NK cell activation and mobilization is dependent on CD1d expression. The administration of M...
  14. Elewaut D, Lawton A, Nagarajan N, Maverakis E, Khurana A, Honing S, et al. The adaptor protein AP-3 is required for CD1d-mediated antigen presentation of glycosphingolipids and development of Valpha14i NKT cells. J Exp Med. 2003;198:1133-46 pubmed
    ..AP-3 interacts with mouse CD1d, and cells from mice deficient for AP-3 have increased cell surface levels of CD1d and decreased expression in late ..
  15. Park Y, Kim H, Ahn J, Yun D, Cho M, Hong S, et al. IL-12p35 promotes antibody-induced joint inflammation by activating NKT cells and suppressing TGF-beta. J Immunol. 2010;185:1476-84 pubmed publisher
  16. Mallevaey T, Fontaine J, Breuilh L, Paget C, Castro Keller A, Vendeville C, et al. Invariant and noninvariant natural killer T cells exert opposite regulatory functions on the immune response during murine schistosomiasis. Infect Immun. 2007;75:2171-80 pubmed
    b>CD1d-restricted natural killer T (NKT) cells represent a heterogeneous population of innate memory immune cells expressing both NK and T-cell markers distributed into two major subsets, i.e...
  17. Yu E, Girardi E, Wang J, Zajonc D. Cutting edge: structural basis for the recognition of ?-linked glycolipid antigens by invariant NKT cells. J Immunol. 2011;187:2079-83 pubmed publisher
    ..a semi-invariant V?14 TCR recognize self and foreign lipid Ags when presented by the nonclassical MHCI homolog CD1d. Whereas the majority of known iNKT cell Ags are characterized by the presence of a single ?-linked sugar, ..
  18. Nieuwenhuis E, Matsumoto T, Exley M, Schleipman R, Glickman J, Bailey D, et al. CD1d-dependent macrophage-mediated clearance of Pseudomonas aeruginosa from lung. Nat Med. 2002;8:588-93 pubmed
    b>CD1d-restricted T cells are implicated as key players in host defense against various microbial infections...
  19. Im J, Arora P, Bricard G, Molano A, Venkataswamy M, Baine I, et al. Kinetics and cellular site of glycolipid loading control the outcome of natural killer T cell activation. Immunity. 2009;30:888-98 pubmed publisher
    b>CD1d-restricted natural killer T cells (NKT cells) possess a wide range of effector and regulatory activities that are related to their ability to secrete both T helper 1 (Th1) cell- and Th2 cell-type cytokines...
  20. Zajonc D, Maricic I, Wu D, Halder R, Roy K, Wong C, et al. Structural basis for CD1d presentation of a sulfatide derived from myelin and its implications for autoimmunity. J Exp Med. 2005;202:1517-26 pubmed
    Sulfatide derived from the myelin stimulates a distinct population of CD1d-restricted natural killer T (NKT) cells...
  21. D Souza C, Cooper A, Frank A, Ehlers S, Turner J, Bendelac A, et al. A novel nonclassic beta2-microglobulin-restricted mechanism influencing early lymphocyte accumulation and subsequent resistance to tuberculosis in the lung. Am J Respir Cell Mol Biol. 2000;23:188-93 pubmed
  22. Sagiv Y, Bai L, Wei D, Agami R, Savage P, Teyton L, et al. A distal effect of microsomal triglyceride transfer protein deficiency on the lysosomal recycling of CD1d. J Exp Med. 2007;204:921-8 pubmed
    ..was recently suggested to directly regulate the biosynthesis of the MHC I-like, lipid antigen presenting molecule CD1d, based on coprecipitation experiments and lipid loading assays...
  23. Shin J, Park J, Shin Y, Lee H, Park Y, Jung S, et al. Mutation of a positively charged cytoplasmic motif within CD1d results in multiple defects in antigen presentation to NKT cells. J Immunol. 2012;188:2235-43 pubmed publisher
    b>CD1d is an MHC class I-like molecule that presents glycolipid Ags to types I and II NKT cells...
  24. Zeng Z, Castaño A, Segelke B, Stura E, Peterson P, Wilson I. Crystal structure of mouse CD1: An MHC-like fold with a large hydrophobic binding groove. Science. 1997;277:339-45 pubmed
    ..The crystal structure of mouse CD1d1, corresponding to human CD1d, at 2...
  25. Stanic A, Bezbradica J, Park J, Matsuki N, Mora A, Van Kaer L, et al. NF-kappa B controls cell fate specification, survival, and molecular differentiation of immunoregulatory natural T lymphocytes. J Immunol. 2004;172:2265-73 pubmed
    ..Thus, antiapoptotic signals relayed by NF-kappaB critically control cell fate specification and molecular differentiation of iNKT cells and, hence, reveal a novel role for such signals within the immune system. ..
  26. Stanic A, De Silva A, Park J, Sriram V, Ichikawa S, Hirabyashi Y, et al. Defective presentation of the CD1d1-restricted natural Va14Ja18 NKT lymphocyte antigen caused by beta-D-glucosylceramide synthase deficiency. Proc Natl Acad Sci U S A. 2003;100:1849-54 pubmed
    ..In striking contrast, the same hybridomas fail to react to CD1d1 expressed by a beta-D-GlcCer-deficient cell line...
  27. Paget C, Mallevaey T, Speak A, Torres D, Fontaine J, Sheehan K, et al. Activation of invariant NKT cells by toll-like receptor 9-stimulated dendritic cells requires type I interferon and charged glycosphingolipids. Immunity. 2007;27:597-609 pubmed
    ..natural killer T (iNKT) cells are a subset of innate lymphocytes that recognize lipid antigens in the context of CD1d and mediate potent immune regulatory functions via the rapid production of interferon-gamma (IFN-gamma) and ..
  28. Miyagi T, Takehara T, Tatsumi T, Kanto T, Suzuki T, Jinushi M, et al. CD1d-mediated stimulation of natural killer T cells selectively activates hepatic natural killer cells to eliminate experimentally disseminated hepatoma cells in murine liver. Int J Cancer. 2003;106:81-9 pubmed
    ..including natural killer (NK) cells and natural killer T (NKT) cells, the latter of which become activated in a CD1d-restricted manner by alpha-galactosylceramide (alpha-GalCer)...
  29. Wei D, Curran S, Savage P, Teyton L, Bendelac A. Mechanisms imposing the Vbeta bias of Valpha14 natural killer T cells and consequences for microbial glycolipid recognition. J Exp Med. 2006;203:1197-207 pubmed
    Mouse and human natural killer T (NKT) cells recognize a restricted set of glycosphingolipids presented by CD1d molecules, including self iGb3 and microbial alpha-glycuronosylceramides...
  30. McNab F, Berzins S, Pellicci D, Kyparissoudis K, Field K, Smyth M, et al. The influence of CD1d in postselection NKT cell maturation and homeostasis. J Immunol. 2005;175:3762-8 pubmed
    After being positively selected on CD1d-expressing thymocytes, NKT cells undergo a series of developmental changes that can take place inside or outside the thymus...
  31. Wang B, Chun T, Wang C. Comparative contribution of CD1 on the development of CD4+ and CD8+ T cell compartments. J Immunol. 2000;164:739-45 pubmed
    ..Our data suggest that, unlike other MHC class I molecules, CD1 does not contribute in a major way to the development of CD8+ T cells...
  32. Hager E, Hawwari A, Matsuda J, Krangel M, Gapin L. Multiple constraints at the level of TCRalpha rearrangement impact Valpha14i NKT cell development. J Immunol. 2007;179:2228-34 pubmed
    b>CD1d-restricted NKT cells that express an invariant Valpha14 TCR represent a subset of T cells implicated in the regulation of several immune responses, including autoimmunity, infectious disease, and cancer...
  33. Shi F, Flodstrom M, Balasa B, Kim S, Van Gunst K, Strominger J, et al. Germ line deletion of the CD1 locus exacerbates diabetes in the NOD mouse. Proc Natl Acad Sci U S A. 2001;98:6777-82 pubmed
    ..Here we demonstrate that both CD1d-null NOD and CD1d-null NOD/BDC2...
  34. Chiu Y, Park S, Benlagha K, Forestier C, Jayawardena Wolf J, Savage P, et al. Multiple defects in antigen presentation and T cell development by mice expressing cytoplasmic tail-truncated CD1d. Nat Immunol. 2002;3:55-60 pubmed
    ..the germ line, and through homologous recombination in embryonic stem cells, we now describe knock-in mice with the CD1d cytoplasmic tail deleted...
  35. Xu H, Chun T, Colmone A, Nguyen H, Wang C. Expression of CD1d under the control of a MHC class Ia promoter skews the development of NKT cells, but not CD8+ T cells. J Immunol. 2003;171:4105-12 pubmed
    ..While the expression of CD1d1 is known to be essential for the development of NKT cells, the contribution of CD1d1 to the development of CD8(+) ..
  36. Mattarollo S, Rahimpour A, Choyce A, Godfrey D, Leggatt G, Frazer I. Invariant NKT cells in hyperplastic skin induce a local immune suppressive environment by IFN-gamma production. J Immunol. 2010;184:1242-50 pubmed publisher
    ..In this study, we show, in a mouse model, that skin-infiltrating CD1d-restricted NKT cells in HPV16-E7 transgenic hyperplastic skin produce IFN-gamma, which can prevent rejection of ..
  37. Wei D, Lee H, Park S, Beaudoin L, Teyton L, Lehuen A, et al. Expansion and long-range differentiation of the NKT cell lineage in mice expressing CD1d exclusively on cortical thymocytes. J Exp Med. 2005;202:239-48 pubmed
    ..After positive selection mediated by CD1d-expressing cortical thymocytes, the mature NKT cell lineage undergoes a series of changes suggesting antigen ..
  38. Barral P, Polzella P, Bruckbauer A, Van Rooijen N, Besra G, Cerundolo V, et al. CD169(+) macrophages present lipid antigens to mediate early activation of iNKT cells in lymph nodes. Nat Immunol. 2010;11:303-12 pubmed publisher
    ..Although it is known that iNKT cells recognize glycolipids presented by CD1d, how and where they encounter antigen in vivo remains unclear...
  39. Brennan P, Tatituri R, Brigl M, Kim E, Tuli A, Sanderson J, et al. Invariant natural killer T cells recognize lipid self antigen induced by microbial danger signals. Nat Immunol. 2011;12:1202-11 pubmed publisher
    ..Thus, we propose that recognition of ?-GlcCer by the invariant T cell antigen receptor translates innate danger signals into iNKT cell activation. ..
  40. Liao C, Zimmer M, Shanmuganad S, Yu H, Cardell S, Wang C. dysregulation of CD1d-restricted type ii natural killer T cells leads to spontaneous development of colitis in mice. Gastroenterology. 2012;142:326-34.e1-2 pubmed publisher
    b>CD1d-restricted natural killer (NK) T cells are a subset of immunoregulatory T cells that comprise type I (express the semi-invariant T-cell receptor [TCR] and can be detected using the ?-galactosylceramide/CD1d tetramer) and type II (..
  41. Park J, Kang S, De Silva A, Stanic A, Casorati G, Hachey D, et al. Lipid-protein interactions: biosynthetic assembly of CD1 with lipids in the endoplasmic reticulum is evolutionarily conserved. Proc Natl Acad Sci U S A. 2004;101:1022-6 pubmed
    ..of lipid antigen presentation by CD1 molecules, we have characterized the natural ligands associated with mouse CD1d1 as well as human CD1b and CD1d molecules...
  42. Teng M, Yue S, Sharkey J, Exley M, Smyth M. CD1d activation and blockade: a new antitumor strategy. J Immunol. 2009;182:3366-71 pubmed publisher
    b>CD1d is expressed on APCs and presents glycolipids to CD1d-restricted NKT cells. For the first time, we demonstrate the ability of anti-CD1d mAbs to inhibit the growth of different CD1d-negative experimental carcinomas in mice...
  43. Wang J, Li Y, Kinjo Y, Mac T, Gibson D, Painter G, et al. Lipid binding orientation within CD1d affects recognition of Borrelia burgorferi antigens by NKT cells. Proc Natl Acad Sci U S A. 2010;107:1535-40 pubmed publisher
    Invariant natural killer T cells (iNKT cells) respond to CD1d-presented glycolipids from Borrelia burgdorferi, the causative agent of Lyme disease...
  44. Hayakawa Y, Takeda K, Yagita H, van Kaer L, Saiki I, Okumura K. Differential regulation of Th1 and Th2 functions of NKT cells by CD28 and CD40 costimulatory pathways. J Immunol. 2001;166:6012-8 pubmed
    ..These results indicate that CD28-CD80/CD86 and CD40-CD154 costimulatory pathways differentially contribute to the regulation of Th1 and Th2 functions of Valpha14 NKT cells in vivo. ..
  45. Ambrosino E, Terabe M, Halder R, Peng J, Takaku S, Miyake S, et al. Cross-regulation between type I and type II NKT cells in regulating tumor immunity: a new immunoregulatory axis. J Immunol. 2007;179:5126-36 pubmed
    ..Alteration of the balance between the protective type I and the suppressive type II NKT cell may be exploited for therapeutic intervention in cancer. ..
  46. Lappas C, Day Y, Marshall M, Engelhard V, Linden J. Adenosine A2A receptor activation reduces hepatic ischemia reperfusion injury by inhibiting CD1d-dependent NKT cell activation. J Exp Med. 2006;203:2639-48 pubmed
    ..1-positive cells (NK and NKT) or to block CD1d-mediated glycolipid presentation to NKT cells replicates, but is not additive to, the protection afforded by ..
  47. Ikarashi Y, Mikami R, Bendelac A, Terme M, Chaput N, Terada M, et al. Dendritic cell maturation overrules H-2D-mediated natural killer T (NKT) cell inhibition: critical role for B7 in CD1d-dependent NKT cell interferon gamma production. J Exp Med. 2001;194:1179-86 pubmed
    Given the broad expression of H-2 class Ib molecules on hematopoietic cells, antigen presentation pathways among CD1d expressing cells might tightly regulate CD1d-restricted natural killer T (NKT) cells...
  48. Motomura Y, Kitamura H, Hijikata A, Matsunaga Y, Matsumoto K, Inoue H, et al. The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells. Nat Immunol. 2011;12:450-9 pubmed publisher
    ..Our results indicate that E4BP4 has multiple functions in controlling the plasticity of IL-13 in T(H)1 cells and IL-10 in T(H)1 cells, T(H)2 cells, T(reg) cells and NKT cells. ..
  49. Chiba A, Cohen N, Brigl M, Brennan P, Besra G, Brenner M. Rapid and reliable generation of invariant natural killer T-cell lines in vitro. Immunology. 2009;128:324-33 pubmed publisher
    Several tools have proved useful in the study of invariant natural killer T (iNKT) cells, including CD1d-deficient mice, J alpha281-deficient mice, synthetic lipid antigens and antigen-loaded CD1d tetramers...
  50. Gadola S, Silk J, Jeans A, Illarionov P, Salio M, Besra G, et al. Impaired selection of invariant natural killer T cells in diverse mouse models of glycosphingolipid lysosomal storage diseases. J Exp Med. 2006;203:2293-303 pubmed
    Glycolipid ligands for invariant natural killer T cells (iNKT cells) are loaded onto CD1d molecules in the late endosome/lysosome...
  51. Zimmer M, Nguyen H, Wang B, Xu H, Colmone A, Felio K, et al. Polymorphisms in CD1d affect antigen presentation and the activation of CD1d-restricted T cells. Proc Natl Acad Sci U S A. 2009;106:1909-14 pubmed publisher
    ..Here, we describe the identification and characterization of CD1d alleles in wild-derived mouse strains...
  52. Rymarchyk S, Lowenstein H, Mayette J, Foster S, Damby D, Howe I, et al. Widespread natural variation in murine natural killer T-cell number and function. Immunology. 2008;125:331-43 pubmed publisher
  53. Renukaradhya G, Khan M, Vieira M, Du W, Gervay Hague J, Brutkiewicz R. Type I NKT cells protect (and type II NKT cells suppress) the host's innate antitumor immune response to a B-cell lymphoma. Blood. 2008;111:5637-45 pubmed publisher
    Natural killer T (NKT) cells are a T-cell subpopulation known to possess immunoregulatory functions and recognize CD1d molecules...
  54. Winau F, Hegasy G, Weiskirchen R, Weber S, Cassan C, Sieling P, et al. Ito cells are liver-resident antigen-presenting cells for activating T cell responses. Immunity. 2007;26:117-29 pubmed
  55. Germanov E, Veinotte L, Cullen R, Chamberlain E, Butcher E, Johnston B. Critical role for the chemokine receptor CXCR6 in homeostasis and activation of CD1d-restricted NKT cells. J Immunol. 2008;181:81-91 pubmed
    ..Preformed transcripts for IL-4, but not IFN-gamma, were reduced in CXCR6-/- liver NKT cells. These data identify critical roles for CXCR6/CXCL16 in NKT cell activation and the regulation of NKT cell homeostasis. ..
  56. Sonoda K, Stein Streilein J. CD1d on antigen-transporting APC and splenic marginal zone B cells promotes NKT cell-dependent tolerance. Eur J Immunol. 2002;32:848-57 pubmed
    b>CD1d-reactive NKT cells are required for the development of antigen-specific T regulatory (Tr) cells responsible for mediating systemic tolerance induced through an immune privileged site such as the eye...
  57. Kitamura H, Iwakabe K, Yahata T, Nishimura S, Ohta A, Ohmi Y, et al. The natural killer T (NKT) cell ligand alpha-galactosylceramide demonstrates its immunopotentiating effect by inducing interleukin (IL)-12 production by dendritic cells and IL-12 receptor expression on NKT cells. J Exp Med. 1999;189:1121-8 pubmed
    ..Our results also suggest a novel approach for immunotherapy of cancer. ..
  58. Yang J, Singh A, Wilson M, Satoh M, Stanic A, Park J, et al. Immunoregulatory role of CD1d in the hydrocarbon oil-induced model of lupus nephritis. J Immunol. 2003;171:2142-53 pubmed
    ..Humans and mice with SLE have reduced numbers of CD1d-restricted NK T cells, suggesting a role for these cells in the regulation of SLE...
  59. Zhou D, Mattner J, Cantu C, Schrantz N, Yin N, Gao Y, et al. Lysosomal glycosphingolipid recognition by NKT cells. Science. 2004;306:1786-9 pubmed
    ..Although the TCR of NKT cells is characteristically autoreactive to CD1d, a lipid-presenting molecule, endogenous ligands for these cells have not been identified...
  60. Arrunategui Correa V, Kim H. The role of CD1d in the immune response against Listeria infection. Cell Immunol. 2004;227:109-20 pubmed
    To address the role of CD1d in mucosal immune regulation in bacterial infection, we infected CD1d KO mice with Listeria monocytogenes (Lm)...
  61. Brozovic S, Nagaishi T, Yoshida M, Betz S, Salas A, Chen D, et al. CD1d function is regulated by microsomal triglyceride transfer protein. Nat Med. 2004;10:535-9 pubmed
    b>CD1d is a major histocompatibility complex (MHC) class I-related molecule that functions in glycolipid antigen presentation to distinct subsets of T cells that express natural killer receptors and an invariant T-cell receptor-alpha chain (..
  62. Benlagha K, Wei D, Veiga J, Teyton L, Bendelac A. Characterization of the early stages of thymic NKT cell development. J Exp Med. 2005;202:485-92 pubmed
    Upon reaching the mature heat stable antigen (HSA)low thymic developmental stage, CD1d-restricted Valpha14-Jalpha18 thymocytes undergo a well-characterized sequence of expansion and differentiation steps that lead to the peripheral ..
  63. Grubor Bauk B, Simmons A, Mayrhofer G, Speck P. Impaired clearance of herpes simplex virus type 1 from mice lacking CD1d or NKT cells expressing the semivariant V alpha 14-J alpha 281 TCR. J Immunol. 2003;170:1430-4 pubmed
    ..In J alpha 281 GKO mice there was also impairment of virus clearance, resembling that seen in CD1 GKO mice. These results imply roles for the V alpha 14-J alpha 281 subset of NKT cells and for CD1d in control of HSV infection.
  64. Brigl M, van den Elzen P, Chen X, Meyers J, Wu D, Wong C, et al. Conserved and heterogeneous lipid antigen specificities of CD1d-restricted NKT cell receptors. J Immunol. 2006;176:3625-34 pubmed
    b>CD1d-restricted NKT cells use structurally conserved TCRs and recognize both self and foreign glycolipids, but the TCR features that determine these Ag specificities remain unclear...
  65. Jayawardena Wolf J, Benlagha K, Chiu Y, Mehr R, Bendelac A. CD1d endosomal trafficking is independently regulated by an intrinsic CD1d-encoded tyrosine motif and by the invariant chain. Immunity. 2001;15:897-908 pubmed
    ..We demonstrate that CD1d access to endosomal compartments is under dual regulation by an intrinsic tyrosine-based motif, which governs ..
  66. Leadbetter E, Brigl M, Illarionov P, Cohen N, Luteran M, Pillai S, et al. NK T cells provide lipid antigen-specific cognate help for B cells. Proc Natl Acad Sci U S A. 2008;105:8339-44 pubmed publisher
    ..This B cell response is absent in CD1d(-/-) and Jalpha18(-/-) mice but not CD4(-/-) mice...
  67. De Santo C, Arscott R, Booth S, Karydis I, Jones M, Asher R, et al. Invariant NKT cells modulate the suppressive activity of IL-10-secreting neutrophils differentiated with serum amyloid A. Nat Immunol. 2010;11:1039-46 pubmed publisher
  68. Ishikawa S, Ikejima K, Yamagata H, Aoyama T, Kon K, Arai K, et al. CD1d-restricted natural killer T cells contribute to hepatic inflammation and fibrogenesis in mice. J Hepatol. 2011;54:1195-204 pubmed publisher
    ..liver injury and subsequent fibrogenesis in mice lacking mature NKT cells caused by genetic disruption of the CD1d molecule...
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    ..The development and activation of iNKT cells is dependent on self-Ags presented by the CD1d Ag-presenting molecule...
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    We have investigated the potential role of CD1d-restricted natural killer T (NKT) cells in the development of atherosclerosis in mice...
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    ..Thus, although dependent on CD1 for their development, IL-4-secreting NK-like T cells are not required for TH2 responses. ..
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    ..Because iNKTs recognize CD1d, we reasoned that CD1d might play a role in the differential regulation of autoreactive versus nonautoreactive B ..
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    ..Absence or reduction of iNKT cells as well as absence of CD1d-expression on B cells, needed for direct iNKT-B cell interaction, leads to increased autoreactive B cell activation ..
  74. Kim J, Kim H, Kim S, Chung J, Park W, Chung D. Natural killer T (NKT) cells attenuate bleomycin-induced pulmonary fibrosis by producing interferon-gamma. Am J Pathol. 2005;167:1231-41 pubmed
    ..bleomycin, and blockade of TGF-beta1 by neutralizing monoclonal antibody attenuated the pulmonary fibrosis in CD1d-/- mice. In contrast, the production of IFN-gamma was reduced in lungs from CD1d-/- mice...
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    A group of T cells recognizes glycolipids presented by molecules of the CD1 family. The CD1d-restricted natural killer T cells (NKT cells) are primarily considered to be self-reactive...
  76. Giabbai B, Sidobre S, Crispin M, Sanchez Ruiz Y, Bachi A, Kronenberg M, et al. Crystal structure of mouse CD1d bound to the self ligand phosphatidylcholine: a molecular basis for NKT cell activation. J Immunol. 2005;175:977-84 pubmed
    ..immunoregulatory lymphocytes whose activation is triggered by the recognition of lipid Ags in the context of the CD1d molecules by the TCR. In this study we present the crystal structure to 2...
  77. Zajonc D, Cantu C, Mattner J, Zhou D, Savage P, Bendelac A, et al. Structure and function of a potent agonist for the semi-invariant natural killer T cell receptor. Nat Immunol. 2005;6:810-8 pubmed
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    To define the phenotype and T cell receptor (TCR) repertoire of CD1d-dependent T cells, we compared the populations of T cells that persisted in major histocompatibility complex (MHC)-deficient mice, which lack mainstream T cells, with ..