Cd14

Summary

Gene Symbol: Cd14
Description: CD14 antigen
Alias: monocyte differentiation antigen CD14, myeloid cell-specific leucine-rich glycoprotein
Species: mouse
Products:     Cd14

Top Publications

  1. Takakuwa T, Knopf H, Sing A, Carsetti R, Galanos C, Freudenberg M. Induction of CD14 expression in Lpsn, Lpsd and tumor necrosis factor receptor-deficient mice. Eur J Immunol. 1996;26:2686-92 pubmed
    The involvement of CD14 in lipopolysaccharide (LPS) recognition and signaling has been demonstrated in several studies...
  2. Metkar S, Awasthi S, Denamur E, Kim K, Gangloff S, Teichberg S, et al. Role of CD14 in responses to clinical isolates of Escherichia coli: effects of K1 capsule expression. Infect Immun. 2007;75:5415-24 pubmed
    ..To determine the role of the CD14 LPS receptor in the pathogenic effects of naturally occurring E...
  3. Kim J, Lee C, Jin M, Lee C, Paik S, Lee H, et al. Crystal structure of CD14 and its implications for lipopolysaccharide signaling. J Biol Chem. 2005;280:11347-51 pubmed
    ..The core receptors recognizing lipopolysaccharide are CD14, TLR4, and MD-2...
  4. Jiang Z, Georgel P, Du X, Shamel L, Sovath S, Mudd S, et al. CD14 is required for MyD88-independent LPS signaling. Nat Immunol. 2005;6:565-70 pubmed
    ..The Heedless phenotype was positionally ascribed to a premature stop codon in Cd14. Our data suggest that the TLR4-MD-2 complex distinguishes LPS chemotypes, but CD14 nullifies this distinction...
  5. Janot L, Secher T, Torres D, Maillet I, Pfeilschifter J, Quesniaux V, et al. CD14 works with toll-like receptor 2 to contribute to recognition and control of Listeria monocytogenes infection. J Infect Dis. 2008;198:115-24 pubmed publisher
    ..Because CD14 may associate with TLR2, we investigated the role of CD14 in Listeria responses...
  6. Akashi S, Saitoh S, Wakabayashi Y, Kikuchi T, Takamura N, Nagai Y, et al. Lipopolysaccharide interaction with cell surface Toll-like receptor 4-MD-2: higher affinity than that with MD-2 or CD14. J Exp Med. 2003;198:1035-42 pubmed
    ..Here, we demonstrate cell surface LPS-TLR4-MD-2 complexes. CD14 greatly enhances the formation of LPS-TLR4-MD-2 complexes, but is not coprecipitated with LPS-TLR4-MD-2 complexes, ..
  7. Pugin J, Heumann I, Tomasz A, Kravchenko V, Akamatsu Y, Nishijima M, et al. CD14 is a pattern recognition receptor. Immunity. 1994;1:509-16 pubmed
    ..Here we show that CD14 plays a key role in initiating cell activation by a group of bacterial envelope components from Gram-negative and ..
  8. Knuefermann P, Nemoto S, Misra A, Nozaki N, Defreitas G, Goyert S, et al. CD14-deficient mice are protected against lipopolysaccharide-induced cardiac inflammation and left ventricular dysfunction. Circulation. 2002;106:2608-15 pubmed
    The molecular mechanisms responsible for sepsis-induced myocardial dysfunction remain undefined. CD14 mediates the inflammatory response to lipopolysaccharide (LPS) in various organs including the heart...
  9. Muroi M, Ohnishi T, Tanamoto K. Regions of the mouse CD14 molecule required for toll-like receptor 2- and 4-mediated activation of NF-kappa B. J Biol Chem. 2002;277:42372-9 pubmed
    Regions of mouse CD14 required for Toll-like receptor 2 (TLR2)- and TLR4-mediated activation of NF-kappaB were studied in transiently transfected 293 cells...

More Information

Publications79

  1. Zanoni I, Ostuni R, Capuano G, Collini M, Caccia M, Ronchi A, et al. CD14 regulates the dendritic cell life cycle after LPS exposure through NFAT activation. Nature. 2009;460:264-8 pubmed publisher
    ..The initiation of this pathway is independent of TLR4 engagement, and dependent exclusively on CD14. We also show that LPS-induced NFAT activation via CD14 is necessary to cause the apoptotic death of terminally ..
  2. Cani P, Amar J, Iglesias M, Poggi M, Knauf C, Bastelica D, et al. Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes. 2007;56:1761-72 pubmed
    ..Furthermore, liver, but not whole-body, insulin resistance was detected in LPS-infused mice. CD14 mutant mice resisted most of the LPS and high-fat diet-induced features of metabolic diseases...
  3. Lee H, Dunzendorfer S, Soldau K, Tobias P. Double-stranded RNA-mediated TLR3 activation is enhanced by CD14. Immunity. 2006;24:153-63 pubmed
    b>CD14 is a well-known pattern-recognition receptor in the innate immune system. Here, we show that CD14 enhances double-stranded RNA (dsRNA)-mediated Toll-like receptor 3 (TLR3) activation...
  4. Ulevitch R, Tobias P. Recognition of gram-negative bacteria and endotoxin by the innate immune system. Curr Opin Immunol. 1999;11:19-22 pubmed
    ..as LPS-binding protein; the LPS in this complex is subsequently transferred to another protein which binds LPS, CD14. The latter is found on the plasma membrane of most cell types of the myeloid lineage as well as in the serum in ..
  5. Seimon T, Obstfeld A, Moore K, Golenbock D, Tabas I. Combinatorial pattern recognition receptor signaling alters the balance of life and death in macrophages. Proc Natl Acad Sci U S A. 2006;103:19794-9 pubmed
    ..PRR-induced macrophage death may play important roles in advanced atherosclerosis and in other innate immunity-related processes in which the balance between macrophage survival and death is critical. ..
  6. Gangloff S, Zahringer U, Blondin C, Guenounou M, Silver J, Goyert S. Influence of CD14 on ligand interactions between lipopolysaccharide and its receptor complex. J Immunol. 2005;175:3940-5 pubmed
    The interaction of LPS (endotoxin) with the CD14-TLR4 receptor complex modulates the host innate immune response...
  7. Knapp S, Wieland C, Florquin S, Pantophlet R, Dijkshoorn L, Tshimbalanga N, et al. Differential roles of CD14 and toll-like receptors 4 and 2 in murine Acinetobacter pneumonia. Am J Respir Crit Care Med. 2006;173:122-9 pubmed
    ..baumannii infection have not been elucidated. To gain first insight into the role of CD14 and Toll-like receptors 4 and 2 in host response to A. baumannii pneumonia...
  8. Isayama F, Hines I, Kremer M, Milton R, Byrd C, Perry A, et al. LPS signaling enhances hepatic fibrogenesis caused by experimental cholestasis in mice. Am J Physiol Gastrointest Liver Physiol. 2006;290:G1318-28 pubmed
    ..a key activator of hepatic macrophages, this study was designed to test the hypothesis that LPS signaling through CD14 contributes to hepatic fibrosis caused by experimental cholestasis...
  9. Perera P, Vogel S, Detore G, Haziot A, Goyert S. CD14-dependent and CD14-independent signaling pathways in murine macrophages from normal and CD14 knockout mice stimulated with lipopolysaccharide or taxol. J Immunol. 1997;158:4422-9 pubmed
    ..Since CD14 is central to the recognition of LPS by macrophages, we sought to examine a role for CD14 in the response to Taxol ..
  10. Tasaka S, Ishizaka A, Yamada W, Shimizu M, Koh H, Hasegawa N, et al. Effect of CD14 blockade on endotoxin-induced acute lung injury in mice. Am J Respir Cell Mol Biol. 2003;29:252-8 pubmed
    b>CD14 functions as a cell surface receptor for endotoxin (lipopolysaccharide [LPS]) and is thought to have an essential role in innate immune responses to infection...
  11. Zanoni I, Ostuni R, Marek L, Barresi S, Barbalat R, Barton G, et al. CD14 controls the LPS-induced endocytosis of Toll-like receptor 4. Cell. 2011;147:868-80 pubmed publisher
    ..Here, we report that the plasma membrane localized Pattern Recognition Receptor (PRR) CD14 is required for the microbe-induced endocytosis of TLR4...
  12. Johnson G, Riggs B, Platt J. A genetic basis for the "Adonis" phenotype of low adiposity and strong bones. FASEB J. 2004;18:1282-4 pubmed
    ..Here, we report that mice harboring mutations in TLR4 or in CD14, a co-receptor for TLR4, have an "ideal" body plan consisting of increased bone mineral content, density, ..
  13. Muthu K, He L, Szilagyi A, Strotmon P, Gamelli R, Shankar R. ß-adrenergic stimulation increases macrophage CD14 expression and E. coli phagocytosis through PKA signaling mechanisms. J Leukoc Biol. 2010;88:715-24 pubmed publisher
    b>CD14 is a glycoprotein that binds bacterial LPS in MØ. It is an essential component of the phagocytic system and is increased in septic shock. Critical injury and sepsis result in elevated endogenous CA levels...
  14. Wieland C, Florquin S, Maris N, Hoebe K, Beutler B, Takeda K, et al. The MyD88-dependent, but not the MyD88-independent, pathway of TLR4 signaling is important in clearing nontypeable haemophilus influenzae from the mouse lung. J Immunol. 2005;175:6042-9 pubmed
    ..TLR4 is the signaling receptor for LPS, the major proinflammatory component of the Gram-negative cell wall, whereas CD14 serves as the ligand-binding part of the LPS receptor complex...
  15. Togbe D, Schofield L, Grau G, Schnyder B, Boissay V, Charron S, et al. Murine cerebral malaria development is independent of toll-like receptor signaling. Am J Pathol. 2007;170:1640-8 pubmed
    ..However, TLR-dependent activation of innate immunity is unlikely to contribute significantly to the proinflammatory response to PbA infection and the development of fatal CM. ..
  16. Moore K, El Khoury J, Medeiros L, Terada K, Geula C, Luster A, et al. A CD36-initiated signaling cascade mediates inflammatory effects of beta-amyloid. J Biol Chem. 2002;277:47373-9 pubmed
  17. Yin M, Bradford B, Wheeler M, Uesugi T, Froh M, Goyert S, et al. Reduced early alcohol-induced liver injury in CD14-deficient mice. J Immunol. 2001;166:4737-42 pubmed
    ..Recently, it was shown that CD14-deficient mice are more resistant to endotoxin-induced shock than wild-type controls...
  18. Haziot A, Hijiya N, Gangloff S, Silver J, Goyert S. Induction of a novel mechanism of accelerated bacterial clearance by lipopolysaccharide in CD14-deficient and Toll-like receptor 4-deficient mice. J Immunol. 2001;166:1075-8 pubmed
    Despite the lack of a proinflammatory response to LPS, CD14-deficient mice clear Gram-negative bacteria (Escherichia coli 0111) at least 10 times more efficiently than normal mice...
  19. Perera P, Mayadas T, Takeuchi O, Akira S, Zaks Zilberman M, Goyert S, et al. CD11b/CD18 acts in concert with CD14 and Toll-like receptor (TLR) 4 to elicit full lipopolysaccharide and taxol-inducible gene expression. J Immunol. 2001;166:574-81 pubmed
    ..Recent reports indicate that three membrane-associated proteins, CD14, CD11b/CD18, and Toll-like receptor (TLR) 4, may serve as LPS recognition and/or signaling receptors in murine ..
  20. Fearns C, Kravchenko V, Ulevitch R, Loskutoff D. Murine CD14 gene expression in vivo: extramyeloid synthesis and regulation by lipopolysaccharide. J Exp Med. 1995;181:857-66 pubmed
    A murine model system was used to study the distribution and regulation of CD14 gene expression in vivo...
  21. Meng J, Parroche P, Golenbock D, McKnight C. The differential impact of disulfide bonds and N-linked glycosylation on the stability and function of CD14. J Biol Chem. 2008;283:3376-84 pubmed
    ..This recognition can be enhanced 100-1000-fold by CD14. However, the beneficial role provided by CD14 becomes detrimental in the context of sepsis and septic shock...
  22. Haziot A, Ferrero E, Kontgen F, Hijiya N, Yamamoto S, Silver J, et al. Resistance to endotoxin shock and reduced dissemination of gram-negative bacteria in CD14-deficient mice. Immunity. 1996;4:407-14 pubmed
    ..b>CD14, a GPI-anchored glycoprotein expressed strongly by monocyte/macrophages, is one of several receptors for endotoxin/..
  23. Benhnia M, Wroblewski D, Akhtar M, Patel R, Lavezzi W, Gangloff S, et al. Signaling through CD14 attenuates the inflammatory response to Borrelia burgdorferi, the agent of Lyme disease. J Immunol. 2005;174:1539-48 pubmed
    ..In vitro evidence suggests that binding of spirochetal lipoproteins to CD14, a pattern recognition receptor expressed on monocytes/macrophages and polymorphonuclear cells, is a critical ..
  24. Shamsul H, Hasebe A, Iyori M, Ohtani M, Kiura K, Zhang D, et al. The Toll-like receptor 2 (TLR2) ligand FSL-1 is internalized via the clathrin-dependent endocytic pathway triggered by CD14 and CD36 but not by TLR2. Immunology. 2010;130:262-72 pubmed publisher
    ..FSL-1 was internalized by human embryonic kidney 293 cells transfected with CD14 or CD36 but not by the non-transfected cells...
  25. Gregory C. CD14-dependent clearance of apoptotic cells: relevance to the immune system. Curr Opin Immunol. 2000;12:27-34 pubmed
    Until very recently, the function of CD14 was thought to be limited to innate immune responses to bacterial and other microbial structures...
  26. Bjorkbacka H, Kunjathoor V, Moore K, Koehn S, Ordija C, Lee M, et al. Reduced atherosclerosis in MyD88-null mice links elevated serum cholesterol levels to activation of innate immunity signaling pathways. Nat Med. 2004;10:416-21 pubmed
    ..development in uninfected, hyperlipidemic mice lacking expression of either lipopolysaccharide (LPS) receptor CD14 or myeloid differentiation protein-88 (MyD88), which transduces cell signaling events downstream of the Toll-like ..
  27. Fearns C, Loskutoff D. Role of tumor necrosis factor alpha in induction of murine CD14 gene expression by lipopolysaccharide. Infect Immun. 1997;65:4822-31 pubmed
    We previously demonstrated CD14 gene expression in myeloid and epithelial cells of the mouse and showed that expression of the CD14 gene in both is modulated by lipopolysaccharide (LPS)...
  28. Moore K, Andersson L, Ingalls R, Monks B, Li R, Arnaout M, et al. Divergent response to LPS and bacteria in CD14-deficient murine macrophages. J Immunol. 2000;165:4272-80 pubmed
    ..The GPI-linked membrane protein, CD14, initiates the signaling cascade responsible for the induction of this inflammatory response by LPS...
  29. Cai S, Zemans R, Young S, Worthen G, Jeyaseelan S. Myeloid differentiation protein-2-dependent and -independent neutrophil accumulation during Escherichia coli pneumonia. Am J Respir Cell Mol Biol. 2009;40:701-9 pubmed publisher
    ..coli-induced pneumonia. LPS-induced CD14-independent neutrophil accumulation was abolished in CD14/MD-2(-/-) mice...
  30. Cani P, Bibiloni R, Knauf C, Waget A, Neyrinck A, Delzenne N, et al. Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice. Diabetes. 2008;57:1470-81 pubmed publisher
    ..e., metabolic endotoxemia. Therefore, it remained to demonstrate whether changes in gut microbiota control the occurrence of metabolic diseases...
  31. Haziot A, Hijiya N, Schultz K, Zhang F, Gangloff S, Goyert S. CD14 plays no major role in shock induced by Staphylococcus aureus but down-regulates TNF-alpha production. J Immunol. 1999;162:4801-5 pubmed
    Recent in vitro studies have suggested that CD14, a major receptor for LPS, may also be a receptor for cell wall components of Gram-positive bacteria and thus play a role in Gram-positive shock...
  32. Brass D, Hollingsworth J, McElvania TeKippe E, Garantziotis S, Hossain I, Schwartz D. CD14 is an essential mediator of LPS-induced airway disease. Am J Physiol Lung Cell Mol Physiol. 2007;293:L77-83 pubmed
    ..b>CD14-deficient mice (C57BL/6(CD14-/-)) have an altered response to systemic LPS, and yet the role of CD14 in the ..
  33. Baumann C, Aspalter I, Sharif O, Pichlmair A, Blüml S, Grebien F, et al. CD14 is a coreceptor of Toll-like receptors 7 and 9. J Exp Med. 2010;207:2689-701 pubmed publisher
    ..In this study, we show that CD14 (cluster of differentiation 14) constitutively interacts with the MyD88-dependent TLR7 and TLR9...
  34. Dunzendorfer S, Lee H, Soldau K, Tobias P. TLR4 is the signaling but not the lipopolysaccharide uptake receptor. J Immunol. 2004;173:1166-70 pubmed
    ..LPS uptake was investigated in primary monocytes and endothelial cells derived from TLR4 and CD14 knockout C57BL/6 mice using tritiated and fluorescein-labeled LPS...
  35. Jeyaseelan S, Chu H, Young S, Freeman M, Worthen G. Distinct roles of pattern recognition receptors CD14 and Toll-like receptor 4 in acute lung injury. Infect Immun. 2005;73:1754-63 pubmed
    ..LPS binding and signaling involves CD14 and Toll-like receptor 4 (TLR4)...
  36. Drennan M, Stijlemans B, Van den Abbeele J, Quesniaux V, Barkhuizen M, Brombacher F, et al. The induction of a type 1 immune response following a Trypanosoma brucei infection is MyD88 dependent. J Immunol. 2005;175:2501-9 pubmed
    ..brucei infections. These results implicate the mammalian TLR family and MyD88 signaling in the innate immune recognition of T. brucei. ..
  37. Chun K, Seong S. CD14 but not MD2 transmit signals from DAMP. Int Immunopharmacol. 2010;10:98-106 pubmed publisher
    ..The TLR4-CD14-MD2 and TLR2-CD14 complexes have been shown to play a role in the recognition of lipopolysaccharide (LPS) and ..
  38. Bate C, Boshuizen R, Williams A. Microglial cells kill prion-damaged neurons in vitro by a CD14-dependent process. J Neuroimmunol. 2005;170:62-70 pubmed
    ..The survival of HuPrP106-126-damaged neurons was increased by pre-treating microglial cells with anti-CD14 antibodies, while microglial cells from CD14 knockout mice failed to kill HuPrP106-126-damaged neurons...
  39. Metkar S, Kim K, Silver J, Goyert S. Differential expression of CD14-dependent and independent pathways for chemokine induction regulates neutrophil trafficking in infection. J Leukoc Biol. 2012;92:389-96 pubmed publisher
    Previous studies have shown that CD14(-/-) mice are resistant to peritoneal infection with some clinical isolates of Escherichia coli and that this resistance is accompanied by an enhanced ability to clear the bacteria; in contrast, ..
  40. Kim S, Kim S, Pribis J, LOTZE M, Mollen K, Shapiro R, et al. Signaling of high mobility group box 1 (HMGB1) through toll-like receptor 4 in macrophages requires CD14. Mol Med. 2013;19:88-98 pubmed publisher
    ..We demonstrate that optimal HMGB1-dependent TLR4 activation in vitro requires the coreceptor CD14. TLR4 and MD2 are recruited into CD14-containing lipid rafts of RAW264...
  41. Drage M, Pecora N, Hise A, Febbraio M, Silverstein R, Golenbock D, et al. TLR2 and its co-receptors determine responses of macrophages and dendritic cells to lipoproteins of Mycobacterium tuberculosis. Cell Immunol. 2009;258:29-37 pubmed publisher
    ..We studied Mtb lipoprotein-induced responses in TLR2(-/-), TLR1(-/-), TLR6(-/-), CD14(-/-) and CD36(-/-) macrophages. Responses to LprA, LprG, LpqH and PhoS1 were completely dependent on TLR2...
  42. von Meyenburg C, Hrupka B, Arsenijevic D, Schwartz G, Landmann R, Langhans W. Role for CD14, TLR2, and TLR4 in bacterial product-induced anorexia. Am J Physiol Regul Integr Comp Physiol. 2004;287:R298-305 pubmed
    The cell surface component CD14 and the toll-like receptors 2 and 4 (TLR2 and TLR4) are important in mediating the immune responses to bacterial products in mammals...
  43. Oakley M, Majam V, Mahajan B, Gerald N, Anantharaman V, Ward J, et al. Pathogenic roles of CD14, galectin-3, and OX40 during experimental cerebral malaria in mice. PLoS ONE. 2009;4:e6793 pubmed publisher
    ..of individual genes to the pathogenesis of ECM, we examined the biological relevance of three molecules -- CD14, galectin-3, and OX40 that were previously shown to be overexpressed during ECM...
  44. Leendertse M, Willems R, Giebelen I, van den Pangaart P, Wiersinga W, de Vos A, et al. TLR2-dependent MyD88 signaling contributes to early host defense in murine Enterococcus faecium peritonitis. J Immunol. 2008;180:4865-74 pubmed
    ..here sought to determine the roles of MyD88, the common adaptor protein involved in TLR signaling, TLR2, TLR4, and CD14 in host defense against E. faecium peritonitis...
  45. Merlin T, Woelky Bruggmann R, Fearns C, Freudenberg M, Landmann R. Expression and role of CD14 in mice sensitized to lipopolysaccharide by Propionibacterium acnes. Eur J Immunol. 2002;32:761-72 pubmed
    Propionibacterium acnes-primed mice develop an IFN-gamma-dependent hypersensitivity towards LPS. Since CD14 plays a key role in LPS-induced cell activation the regulation and function of CD14 in this sensitization process were studied in ..
  46. Wieland C, van der Windt G, Wiersinga W, Florquin S, van der Poll T. CD14 contributes to pulmonary inflammation and mortality during murine tuberculosis. Immunology. 2008;125:272-9 pubmed publisher
    Toll-like receptors play an essential role in the innate recognition of micro-organisms by the host. CD14 is one of the extracellular adaptor proteins required for recognition of Gram-negative bacteria and possibly also Mycobacterium ..
  47. Barber R, Maass D, White D, Chang L, Horton J. Molecular or pharmacologic inhibition of the CD14 signaling pathway protects against burn-related myocardial inflammation and dysfunction. Shock. 2008;30:705-13 pubmed publisher
    ..We hypothesized that signaling through CD14, a cellular receptor for endotoxin that lacks a transmembrane domain but is coupled to TLR4, also plays a role in ..
  48. Du L, Rong H, Cheng Y, Guo S, Shi Q, Jia X, et al. Identification of microRNAs dysregulated in CD14 gene silencing RAW264.7 macrophage cells. Inflammation. 2014;37:287-94 pubmed publisher
    A cluster of differentiation antigen 14 (CD14) is involved in lipopolysaccharide (LPS)-induced proinflammatory cytokine release and LPS-induced septic shock...
  49. Viriyakosol S, Matthias M, Swancutt M, Kirkland T, Vinetz J. Toll-like receptor 4 protects against lethal Leptospira interrogans serovar icterohaemorrhagiae infection and contributes to in vivo control of leptospiral burden. Infect Immun. 2006;74:887-95 pubmed
    ..Anti-TLR4 and anti-MD-2 but not anti-CD14 monoclonal antibodies inhibited cytokine production...
  50. Hoebe K, Du X, Goode J, Mann N, Beutler B. Lps2: a new locus required for responses to lipopolysaccharide, revealed by germline mutagenesis and phenotypic screening. J Endotoxin Res. 2003;9:250-5 pubmed
    ..Gene knockout work has also established that LPS signal transduction requires the integrity of CD14, MD-2, and, in part, MyD88, IRAK4, and TRAF-6...
  51. Cho K, Adamson L, Jeong J, Crivello S, Vanhook T, Palmieri T, et al. CD14-dependent alterations in c-Jun expression in the liver after burn injury. J Surg Res. 2004;122:36-42 pubmed
    Burn injury-triggered activation of lipopolysaccharide signaling via the CD14 pathway alters the expression of a variety of downstream genes contributing to pathogenic changes in distant organs...
  52. Knapp S, Matt U, Leitinger N, van der Poll T. Oxidized phospholipids inhibit phagocytosis and impair outcome in gram-negative sepsis in vivo. J Immunol. 2007;178:993-1001 pubmed
    ..OxPAPC) inhibits the interaction of LPS with LPS-binding protein and CD14. In this study, we determined the functional properties of OxPAPC and potential interference with CD14 during ..
  53. Kuo W, Lee T, Yang H, Chen C, Au Y, Lu Y, et al. LPS receptor subunits have antagonistic roles in epithelial apoptosis and colonic carcinogenesis. Cell Death Differ. 2015;22:1590-604 pubmed publisher
    ..is involved in both epithelial homeostasis and tumorigenesis, but the relative roles had by LPS receptor subunits CD14 and Toll-like receptor 4 (TLR4) are poorly understood...
  54. Mendel I, Feige E, Yacov N, Salem Y, Levi I, Propheta Meiran O, et al. VB-201, an oxidized phospholipid small molecule, inhibits CD14- and Toll-like receptor-2-dependent innate cell activation and constrains atherosclerosis. Clin Exp Immunol. 2014;175:126-37 pubmed publisher
    ..Mechanistically, we show that VB-201 binds directly to TLR-2 and CD14, the TLR-4 co-receptor, to impair downstream cues and cytokine production...
  55. Fejer G, Wegner M, Gyory I, Cohen I, Engelhard P, Voronov E, et al. Nontransformed, GM-CSF-dependent macrophage lines are a unique model to study tissue macrophage functions. Proc Natl Acad Sci U S A. 2013;110:E2191-8 pubmed publisher
    ..In conclusion, Max Planck Institute cells offer an useful tool to study macrophage biology and for biomedical science...
  56. Nagayasu E, Nagakura K, Akaki M, Tamiya G, Makino S, Nakano Y, et al. Association of a determinant on mouse chromosome 18 with experimental severe Plasmodium berghei malaria. Infect Immun. 2002;70:512-6 pubmed
    ..A region of mid-chromosome 18 was found to be a major determinant of resistance to ESM. ..
  57. Bate C, Veerhuis R, Eikelenboom P, Williams A. Microglia kill amyloid-beta1-42 damaged neurons by a CD14-dependent process. Neuroreport. 2004;15:1427-30 pubmed
    ..Pre-treating microglia with polyclonal antibodies to the CD14 protein, or treating neurons exposed to amyloid-beta1-42 with a CD14-IgG chimera, prevented the killing of amyloid-..
  58. Yauch L, Mansour M, Shoham S, Rottman J, Levitz S. Involvement of CD14, toll-like receptors 2 and 4, and MyD88 in the host response to the fungal pathogen Cryptococcus neoformans in vivo. Infect Immun. 2004;72:5373-82 pubmed
    ..of Cryptococcus neoformans, glucuronoxylomannan (GXM), is recognized by Toll-like receptor 2 (TLR2), TLR4, and CD14. In these studies, mice deficient in CD14, TLR2, TLR4, and the TLR-associated adaptor protein, MyD88, were utilized ..
  59. de Buhr M, Mahler M, Geffers R, Hansen W, Westendorf A, Lauber J, et al. Cd14, Gbp1, and Pla2g2a: three major candidate genes for experimental IBD identified by combining QTL and microarray analyses. Physiol Genomics. 2006;25:426-34 pubmed
    ..Three major candidate genes (Cd14, Gbp1, Pla2g2a) showed prominent expression differences between B6- and C3-Il10(-/-) as well as between B6 and C3 ..
  60. Zivkovic A, Sharif O, Stich K, Doninger B, Biaggio M, Colinge J, et al. TLR 2 and CD14 mediate innate immunity and lung inflammation to staphylococcal Panton-Valentine leukocidin in vivo. J Immunol. 2011;186:1608-17 pubmed publisher
    ..Further studies indicate that PVL directly binds to TLR2 and induces immune responses via NF-?B in a TLR2, CD14, MyD88, IL-1R-associated kinase 1, and TNFR-associated factor 6-dependent manner...
  61. Fernandez Real J, Pérez Del Pulgar S, Luche E, Moreno Navarrete J, Waget A, Serino M, et al. CD14 modulates inflammation-driven insulin resistance. Diabetes. 2011;60:2179-86 pubmed publisher
    The study objective was to evaluate the possible role of the macrophage molecule CD14 in insulin resistance...
  62. Borzęcka K, Płóciennikowska A, Björkelund H, Sobota A, Kwiatkowska K. CD14 mediates binding of high doses of LPS but is dispensable for TNF-? production. Mediators Inflamm. 2013;2013:824919 pubmed publisher
    ..with lipopolysaccharide (LPS) involves a sequential engagement of serum LPS-binding protein (LBP), plasma membrane CD14, and TLR4/MD-2 signaling complex...
  63. Janova H, Böttcher C, Holtman I, Regen T, van Rossum D, Götz A, et al. CD14 is a key organizer of microglial responses to CNS infection and injury. Glia. 2016;64:635-49 pubmed publisher
    ..We show that its co-receptor CD14 serves three non-redundant functions in microglia...
  64. Zhao J, Wei J, Dong S, Bowser R, Zhang L, Jacko A, et al. Destabilization of Lysophosphatidic Acid Receptor 1 Reduces Cytokine Release and Protects Against Lung Injury. EBioMedicine. 2016;10:195-203 pubmed publisher
    ..Knockdown or inhibition of USP11 reduces LPA1 stability, levels of LPA1, and LPA1-CD14 interaction complex; thereby diminishing both LPA- and LPS-induced inflammatory responses and lung injury in ..
  65. Augusto L, Synguelakis M, Johansson J, Pedron T, Girard R, Chaby R. Interaction of pulmonary surfactant protein C with CD14 and lipopolysaccharide. Infect Immun. 2003;71:61-7 pubmed
    ..In this study, we show that SP-C also interacts with CD14. Four observations showed cross talk between the three molecules SP-C, LPS, and CD14...
  66. Shao H, Lee S, Gae Scott S, Nakata C, Chen S, Hamad A, et al. Extracellular matrix lumican promotes bacterial phagocytosis, and Lum-/- mice show increased Pseudomonas aeruginosa lung infection severity. J Biol Chem. 2012;287:35860-72 pubmed publisher
    ..critical role for lumican, the connective tissue extracellular matrix small leucine-rich repeat proteoglycan, in CD14-mediated bacterial phagocytosis...
  67. Narayanan K, Seufzer B, Brockman Schneider R, Gern J, Balakrishnan A, Miyamoto S. CD14-dependent activation of NF-kappaB by filarial parasitic sheath proteins. Cell Biol Int. 2002;26:43-54 pubmed
    ..Herein we provide evidence that FPS activation of NF-kappaB can be augmented by the cell surface expression of CD14. CD14 expression, however, is not sufficient to transduce FPS signals for NF-kappaB activation, since its ..
  68. Du B, Luo W, Li R, Tan B, Han H, Lu X, et al. Lgr4/Gpr48 negatively regulates TLR2/4-associated pattern recognition and innate immunity by targeting CD14 expression. J Biol Chem. 2013;288:15131-41 pubmed publisher
    ..The expression of CD14, a co-receptor for TLR2/4-associated pathogen-associated molecular patterns, is increased significantly in Lgr4-..
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