Gene Symbol: Cct7
Description: chaperonin containing Tcp1, subunit 7 (eta)
Alias: AA408524, AL022769, Ccth, Cctz, T-complex protein 1 subunit eta, CCT-eta, TCP-1-eta, chaperonin containing t-complex subunit eta, chaperonin subunit 7 (eta)
Species: mouse
Products:     Cct7

Top Publications

  1. Hynes G, Kubota H, Willison K. Antibody characterisation of two distinct conformations of the chaperonin-containing TCP-1 from mouse testis. FEBS Lett. 1995;358:129-32 pubmed
  2. Hanafy K, Martin E, Murad F. CCTeta, a novel soluble guanylyl cyclase-interacting protein. J Biol Chem. 2004;279:46946-53 pubmed
    ..These data suggest that CCTeta binds to sGC and, in cooperation with some other factor, inhibits its activity by modifying the binding of NO to the heme group or the subsequent conformational changes. ..
  3. Kubota H, Hynes G, Carne A, Ashworth A, Willison K. Identification of six Tcp-1-related genes encoding divergent subunits of the TCP-1-containing chaperonin. Curr Biol. 1994;4:89-99 pubmed
    ..Cctb, Cctg, Cctd, Ccte, Cctz and Ccth, which encode the CCT beta, CCT gamma, CCT delta, CCT epsilon, CCT zeta and CCT eta subunits, respectively, of the 'Chaperonin Containing TCP-1' (CCT)...
  4. Lu K, Ramos K. Identification of genes differentially expressed in vascular smooth muscle cells following benzo[a]pyrene challenge: implications for chemical atherogenesis. Biochem Biophys Res Commun. 1998;253:828-33 pubmed
    ..Of particular interest is the modulation of retrotransposon mRNAs which coupled to other genetic events, may play a significant role in the atherogenic response to this carcinogen. ..
  5. Kubota H, Yokota S, Yanagi H, Yura T. Structures and co-regulated expression of the genes encoding mouse cytosolic chaperonin CCT subunits. Eur J Biochem. 1999;262:492-500 pubmed
    ..We have cloned seven CCT subunit genes, Cctb, Cctd, Ccte, Cctz-1, Cctz-2 (testis specific), Ccth and Cctq, from mouse genomic DNA libraries, in addition to the Ccta and Cctg ..
  6. Hynes G, Willison K. Individual subunits of the eukaryotic cytosolic chaperonin mediate interactions with binding sites located on subdomains of beta-actin. J Biol Chem. 2000;275:18985-94 pubmed
    ..A model is proposed in which actin interacts with several CCT subunits during its CCT-mediated folding cycle. ..
  7. Yokota S, Yanagi H, Yura T, Kubota H. Cytosolic chaperonin-containing t-complex polypeptide 1 changes the content of a particular subunit species concomitant with substrate binding and folding activities during the cell cycle. Eur J Biochem. 2001;268:4664-73 pubmed
    ..These results suggest that the content of alpha and delta subunits of CCT reduces from the complete active complex in S phase cells to incomplete inactive complex in M phase cells. ..
  8. Dun M, Smith N, Baker M, Lin M, Aitken R, Nixon B. The chaperonin containing TCP1 complex (CCT/TRiC) is involved in mediating sperm-oocyte interaction. J Biol Chem. 2011;286:36875-87 pubmed publisher
    ..Collectively, these data provide an important biochemical insight into the molecular basis of sperm-zona pellucida interaction and a plausible explanation for how spermatozoa gain their ability to fertilize. ..
  9. O Bryan J, Frye R, Cogswell P, Neubauer A, Kitch B, Prokop C, et al. axl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase. Mol Cell Biol. 1991;11:5016-31 pubmed

More Information


  1. Kubota H, Hynes G, Willison K. The chaperonin containing t-complex polypeptide 1 (TCP-1). Multisubunit machinery assisting in protein folding and assembly in the eukaryotic cytosol. Eur J Biochem. 1995;230:3-16 pubmed
    ..This complex behaviour of CCT may have evolved to cope with the folding and assembly of certain highly evolved proteins in eukaryotic cells. ..
  2. Liou A, Willison K. Elucidation of the subunit orientation in CCT (chaperonin containing TCP1) from the subunit composition of CCT micro-complexes. EMBO J. 1997;16:4311-6 pubmed