Ccr9

Summary

Gene Symbol: Ccr9
Description: chemokine (C-C motif) receptor 9
Alias: A130091K22Rik, Cmkbr10, GPR-9-6, C-C chemokine receptor type 9, C-C CKR-9, CC-CKR-9, CCR-9, chemokine C-C receptor 10
Species: mouse
Products:     Ccr9

Top Publications

  1. Wendland M, Czeloth N, Mach N, Malissen B, Kremmer E, Pabst O, et al. CCR9 is a homing receptor for plasmacytoid dendritic cells to the small intestine. Proc Natl Acad Sci U S A. 2007;104:6347-52 pubmed
    ..Furthermore, intestinal pDC carry high levels of CCR9 and are largely absent in the intestine, but not in lung, liver, or secondary lymphoid organs of CCR9-deficient ..
  2. Nakamoto N, Ebinuma H, Kanai T, Chu P, Ono Y, Mikami Y, et al. CCR9+ macrophages are required for acute liver inflammation in mouse models of hepatitis. Gastroenterology. 2012;142:366-76 pubmed publisher
    ..carbon tetrachloride to induce acute liver inflammation in mice and studied the roles of macrophages that express CCR9. After injection of con A, we detected CCR9(+)CD11b(+)CD11c(-) macrophages that express tumor necrosis factor (TNF)-..
  3. Chu P, Nakamoto N, Ebinuma H, Usui S, Saeki K, Matsumoto A, et al. C-C motif chemokine receptor 9 positive macrophages activate hepatic stellate cells and promote liver fibrosis in mice. Hepatology. 2013;58:337-50 pubmed publisher
    ..We confirmed that tumor necrosis factor alpha (TNF-?)-producing CCR9(+) macrophages accumulated during the initiation of carbon tetrachloride (CCl4 )-induced liver injury, and CCR9 ..
  4. Wurbel M, Malissen M, Guy Grand D, Meffre E, Nussenzweig M, Richelme M, et al. Mice lacking the CCR9 CC-chemokine receptor show a mild impairment of early T- and B-cell development and a reduction in T-cell receptor gammadelta(+) gut intraepithelial lymphocytes. Blood. 2001;98:2626-32 pubmed
    ..To study the biologic role of CCR9, a mouse strain was generated in which the CCR9 gene was deleted...
  5. Uehara S, Grinberg A, Farber J, Love P. A role for CCR9 in T lymphocyte development and migration. J Immunol. 2002;168:2811-9 pubmed
    b>CCR9 mediates chemotaxis in response to CCL25/thymus-expressed chemokine and is selectively expressed on T cells in the thymus and small intestine...
  6. Johansson Lindbom B, Svensson M, Wurbel M, Malissen B, Marquez G, Agace W. Selective generation of gut tropic T cells in gut-associated lymphoid tissue (GALT): requirement for GALT dendritic cells and adjuvant. J Exp Med. 2003;198:963-9 pubmed
    ..Thus, DCs from mesenteric LNs (MLNs), but not from spleen, supported expression of the chemokine receptor CCR9 and integrin alpha4beta7 by activated CD8+ T cells...
  7. Zaballos A, Gutierrez J, Varona R, Ardavin C, Marquez G. Cutting edge: identification of the orphan chemokine receptor GPR-9-6 as CCR9, the receptor for the chemokine TECK. J Immunol. 1999;162:5671-5 pubmed
    ..These results confirm that GPR-9-6 is a specific receptor for TECK. According to the established nomenclature system, we propose to rename GPR-9-6 as CC chemokine receptor 9 (CCR9).
  8. Ericsson A, Svensson M, Arya A, Agace W. CCL25/CCR9 promotes the induction and function of CD103 on intestinal intraepithelial lymphocytes. Eur J Immunol. 2004;34:2720-9 pubmed
    The integrin CD103 and the chemokine receptor CCR9 are co-expressed on small intestinal CD8(+) intraepithelial lymphocytes (IEL), naïve murine CD8(+) T cells and by a small population of effector/memory CD8(+) T cells, indicating a ..
  9. Wurbel M, Philippe J, Nguyen C, Victorero G, Freeman T, Wooding P, et al. The chemokine TECK is expressed by thymic and intestinal epithelial cells and attracts double- and single-positive thymocytes expressing the TECK receptor CCR9. Eur J Immunol. 2000;30:262-71 pubmed
    ..differentiation, we have characterized the cDNA coding for the thymus-expressed chemokine (TECK) and its receptor CCR9. The TECK receptor gene was isolated and shown to be localized on the mouse chromosome 9F1-F4...

More Information

Publications60

  1. Svensson M, Marsal J, Ericsson A, Carramolino L, Brodén T, Marquez G, et al. CCL25 mediates the localization of recently activated CD8alphabeta(+) lymphocytes to the small-intestinal mucosa. J Clin Invest. 2002;110:1113-21 pubmed
    ..Here we show that the CC chemokine receptor 9 (CCR9) is selectively and functionally expressed on murine alpha(E)beta(7)(+) naive CD8alphabeta(+) lymphocytes and a ..
  2. Mora J, Bono M, Manjunath N, Weninger W, Cavanagh L, Rosemblatt M, et al. Selective imprinting of gut-homing T cells by Peyer's patch dendritic cells. Nature. 2003;424:88-93 pubmed
    ..effector/memory cells that express essential receptors for intestinal homing, namely the integrin alpha4beta7 and CCR9, the receptor for the gut-associated chemokine TECK/CCL25 (refs 6, 8, 9)...
  3. Wurbel M, Malissen M, Guy Grand D, Malissen B, Campbell J. Impaired accumulation of antigen-specific CD8 lymphocytes in chemokine CCL25-deficient intestinal epithelium and lamina propria. J Immunol. 2007;178:7598-606 pubmed
    CCL25 and CCR9 constitute a chemokine/receptor pair involved in T cell development and in gut-associated immune responses...
  4. Benz C, Heinzel K, Bleul C. Homing of immature thymocytes to the subcapsular microenvironment within the thymus is not an absolute requirement for T cell development. Eur J Immunol. 2004;34:3652-63 pubmed
    ..Here we show that the chemokine receptor CCR9 plays a nonredundant role in the homing of immature thymocytes to the subcapsular zone...
  5. Schwarz B, Sambandam A, Maillard I, Harman B, Love P, Bhandoola A. Selective thymus settling regulated by cytokine and chemokine receptors. J Immunol. 2007;178:2008-17 pubmed
    ..v. transfer. This cellular specificity correlated with the expression of the chemokine receptor CCR9 by a subset of MPP and common lymphoid progenitors but not hemopoietic stem cells...
  6. Apostolaki M, Manoloukos M, Roulis M, Wurbel M, Muller W, Papadakis K, et al. Role of beta7 integrin and the chemokine/chemokine receptor pair CCL25/CCR9 in modeled TNF-dependent Crohn's disease. Gastroenterology. 2008;134:2025-35 pubmed publisher
    ..we address the requirement for intestinal-specific homing molecules, the chemokine/chemokine receptor pair CCL25/CCR9 and beta7 integrin, in the pathogenesis of the CD8(+) T cell-dependent Tnf(DeltaARE) mouse model of Crohn's-like ..
  7. Stenstad H, Ericsson A, Johansson Lindbom B, Svensson M, Marsal J, Mack M, et al. Gut-associated lymphoid tissue-primed CD4+ T cells display CCR9-dependent and -independent homing to the small intestine. Blood. 2006;107:3447-54 pubmed
    ..propria lymphocytes express a heterogeneous but restricted array of chemokine receptors including CCR5, CCR6, CCR9, CXCR3, and CXCR6...
  8. Benz C, Bleul C. A multipotent precursor in the thymus maps to the branching point of the T versus B lineage decision. J Exp Med. 2005;202:21-31 pubmed
    ..Thus, the newly identified precursor maps to the branching point of the T versus B lineage decision in the hematopoietic lineage hierarchy. ..
  9. Wurbel M, Malissen B, Campbell J. Complex regulation of CCR9 at multiple discrete stages of T cell development. Eur J Immunol. 2006;36:73-81 pubmed
    We have conducted a comprehensive assessment of CCR9 expression and function at the important milestone stages of murine thymocyte development...
  10. Staton T, Habtezion A, Winslow M, Sato T, Love P, Butcher E. CD8+ recent thymic emigrants home to and efficiently repopulate the small intestine epithelium. Nat Immunol. 2006;7:482-8 pubmed
    ..Here we demonstrate that CD8(+) recent thymic emigrants (RTEs) migrated directly into the small intestine. CCR9, CCL25 and alpha(4)beta(7) integrin were required for gut entry of CD8(+) RTEs...
  11. Wermers J, McNamee E, Wurbel M, Jedlicka P, Rivera Nieves J. The chemokine receptor CCR9 is required for the T-cell-mediated regulation of chronic ileitis in mice. Gastroenterology. 2011;140:1526-35.e3 pubmed publisher
    ..We sought to determine whether interaction between the chemokine receptor 9 (CCR9) and its ligand, chemokine ligand 25 (CCL25), allows effectors or Tregs to localize to chronically inflamed small ..
  12. Yokoyama W, Kohsaka H, Kaneko K, Walters M, Takayasu A, Fukuda S, et al. Abrogation of CC chemokine receptor 9 ameliorates collagen-induced arthritis of mice. Arthritis Res Ther. 2014;16:445 pubmed publisher
    ..study was carried out to explore the pathogenic roles of chemokine (C-C motif) ligand (CCL) 25 and its receptor, CCR9, in autoimmune arthritis and to study if the CCR9 antagonist could be a new treatment for RA...
  13. Mizuno S, Kanai T, Mikami Y, Sujino T, Ono Y, Hayashi A, et al. CCR9+ plasmacytoid dendritic cells in the small intestine suppress development of intestinal inflammation in mice. Immunol Lett. 2012;146:64-9 pubmed publisher
    ..To determine the role of CCR9(+) plasmacytoid dendritic cells (pDCs) in intestinal homeostasis of the SI we transferred CD4(+)CD45RB(high) T ..
  14. Cassani B, Villablanca E, Quintana F, Love P, Lacy Hulbert A, Blaner W, et al. Gut-tropic T cells that express integrin ?4?7 and CCR9 are required for induction of oral immune tolerance in mice. Gastroenterology. 2011;141:2109-18 pubmed publisher
    ..We investigated whether gut-tropic T cells that express the integrin ?4?7 and the chemokine receptor CCR9 are required for OT...
  15. Zlotoff D, Zhang S, De Obaldia M, Hess P, Todd S, Logan T, et al. Delivery of progenitors to the thymus limits T-lineage reconstitution after bone marrow transplantation. Blood. 2011;118:1962-70 pubmed publisher
    ..Under normal physiologic conditions, thymic settling is selective and either CCR7 or CCR9 is required for progenitor access into the thymus...
  16. Calderón L, Boehm T. Three chemokine receptors cooperatively regulate homing of hematopoietic progenitors to the embryonic mouse thymus. Proc Natl Acad Sci U S A. 2011;108:7517-22 pubmed publisher
    ..of mice deficient for one, two, or three of the chemokine receptor genes, chemokine (C-C motif) receptor 9 (Ccr9), chemokine (C-C motif) receptor 7 (Ccr7), and chemokine (C-X-C motif) receptor 4 (Cxcr4)...
  17. Wurbel M, McIntire M, Dwyer P, Fiebiger E. CCL25/CCR9 interactions regulate large intestinal inflammation in a murine model of acute colitis. PLoS ONE. 2011;6:e16442 pubmed publisher
    CCL25/CCR9 is a non-promiscuous chemokine/receptor pair and a key regulator of leukocyte migration to the small intestine...
  18. Zhang S, Wang X, Manna S, Zlotoff D, Bryson J, Blazar B, et al. Chemokine treatment rescues profound T-lineage progenitor homing defect after bone marrow transplant conditioning in mice. Blood. 2014;124:296-304 pubmed publisher
    ..These data suggest new therapeutic approaches to promote T-cell regeneration. ..
  19. Zlotoff D, Sambandam A, Logan T, Bell J, Schwarz B, Bhandoola A. CCR7 and CCR9 together recruit hematopoietic progenitors to the adult thymus. Blood. 2010;115:1897-905 pubmed publisher
    ..The chemokine receptor CCR9 has been demonstrated to be important in this process...
  20. Kiss H, Darai E, Kiss C, Kost Alimova M, Klein G, Dumanski J, et al. Comparative human/murine sequence analysis of the common eliminated region 1 from human 3p21.3. Mamm Genome. 2002;13:646-55 pubmed
    ..We also recognized a large number of conserved elements that were neither exons, CpG islands, nor repeats. We further identified and characterized five novel orthologous mouse genes (Kiaa0028, Xtrp3s1, Fyco1, Tmem7, and Lrrc2). ..
  21. Ikawa T, Masuda K, Lu M, Minato N, Katsura Y, Kawamoto H. Identification of the earliest prethymic T-cell progenitors in murine fetal blood. Blood. 2004;103:530-7 pubmed
    ..We propose that the wave of p-Ts in fetal blood disclosed by this study represents the ontogenically earliest thymic immigrants. ..
  22. Krueger A, Willenzon S, Lyszkiewicz M, Kremmer E, Forster R. CC chemokine receptor 7 and 9 double-deficient hematopoietic progenitors are severely impaired in seeding the adult thymus. Blood. 2010;115:1906-12 pubmed publisher
    ..bone marrow-derived precursor cells to the thymus via a multistep adhesion cascade involving the chemokine receptor CCR9. However, CCR9 deficiency does not result in complete abrogation of progenitor entry into the adult thymus...
  23. Uehara S, Song K, Farber J, Love P. Characterization of CCR9 expression and CCL25/thymus-expressed chemokine responsiveness during T cell development: CD3(high)CD69+ thymocytes and gammadeltaTCR+ thymocytes preferentially respond to CCL25. J Immunol. 2002;168:134-42 pubmed
    b>CCR9 mediates chemotaxis of thymocytes in response to CCL25/thymus-expressed chemokine, and its mRNA is selectively expressed in thymus and small intestine, the two known sites of T lymphopoiesis...
  24. Svensson M, Marsal J, Uronen Hansson H, Cheng M, Jenkinson W, Cilio C, et al. Involvement of CCR9 at multiple stages of adult T lymphopoiesis. J Leukoc Biol. 2008;83:156-64 pubmed
    The chemokine CCL25 is constitutively expressed in the thymus, and its receptor CCR9 is expressed on subsets of developing thymocytes. Nevertheless, the function of CCL25/CCR9 in adult thymopoiesis remains unclear...
  25. Li J, Xiong T, Xiao R, Xiong A, Chen J, Altaf E, et al. Anti-CCL25 antibody prolongs skin allograft survival by blocking CCR9 expression and impairing splenic T-cell function. Arch Immunol Ther Exp (Warsz). 2013;61:237-44 pubmed publisher
    ..b>CCR9 and its ligand, CCL25, is one of the key regulators of thymocyte migration and maturation in normal and ..
  26. Norment A, Bogatzki L, Gantner B, Bevan M. Murine CCR9, a chemokine receptor for thymus-expressed chemokine that is up-regulated following pre-TCR signaling. J Immunol. 2000;164:639-48 pubmed
    ..Hence, GPR-9-6 has been designated as CC chemokine receptor 9 (CCR9). Our results suggest that TECK delivers signals through CCR9 important for the navigation of developing thymocytes. ..
  27. Rojas López A, Soldevila G, Meza Perez S, Dupont G, Ostoa Saloma P, Wurbel M, et al. CCR9+ T cells contribute to the resolution of the inflammatory response in a mouse model of intestinal amoebiasis. Immunobiology. 2012;217:795-807 pubmed publisher
    ..of regulatory T cells has recently been identified and is characterized by the expression of the chemokine receptor CCR9. In this report, we used CCR9 deficient (CCR9(-/-)) mice to investigate the role of the CCR9(+) T cells in a murine ..
  28. Wang X, Sumida H, Cyster J. GPR18 is required for a normal CD8αα intestinal intraepithelial lymphocyte compartment. J Exp Med. 2014;211:2351-9 pubmed publisher
    ..These findings establish a requirement for GPR18 in CD8αα and CD8αβ IELs, and we suggest the receptor has a role in augmenting the accumulation of CD8 T cells in the intraepithelial versus lamina propria compartment. ..
  29. De Obaldia M, Bell J, Bhandoola A. Early T-cell progenitors are the major granulocyte precursors in the adult mouse thymus. Blood. 2013;121:64-71 pubmed publisher
    ..These data indicate that myelolymphoid progenitors settle the thymus and thus clarify the pathways by which stem cells give rise to downstream blood cell lineages. ..
  30. Liu C, Saito F, Liu Z, Lei Y, Uehara S, Love P, et al. Coordination between CCR7- and CCR9-mediated chemokine signals in prevascular fetal thymus colonization. Blood. 2006;108:2531-9 pubmed
    ..Here we show that mice doubly deficient for chemokine receptors CCR7 and CCR9 were defective specifically in fetal thymus colonization before, but not after, thymus vascularization...
  31. Schreder A, Moschovakis G, Halle S, Schlue J, Lee C, Schippers A, et al. Differential Effects of Gut-Homing Molecules CC Chemokine Receptor 9 and Integrin-β7 during Acute Graft-versus-Host Disease of the Liver. Biol Blood Marrow Transplant. 2015;21:2069-2078 pubmed publisher
    ..However, infiltration of donor T cells in gut but not liver was dependent of MAdCAM-1 expression, indicating, that homing and/or retention of donor T cells rests on divergent molecular pathways depending on the GVHD target tissue. ..
  32. Mizukami T, Kanai T, Mikami Y, Hayashi A, Doi T, Handa T, et al. CCR9+ macrophages are required for eradication of peritoneal bacterial infections and prevention of polymicrobial sepsis. Immunol Lett. 2012;147:75-9 pubmed publisher
    ..We found that the mucosal homing receptor CCR9, is induced in peritoneal macrophages in response to inflammatory stimulation...
  33. Dzutsev A, Hogg A, Sui Y, Solaymani Mohammadi S, Yu H, Frey B, et al. Differential T cell homing to colon vs. small intestine is imprinted by local CD11c+ APCs that determine homing receptors. J Leukoc Biol. 2017;102:1381-1388 pubmed publisher
    ..small intestine, and that the differences are related to the variable ability of APCs to induce ?4?7-integrin and CCR9 expression on T cells...
  34. Hoyler T, Klose C, Souabni A, Turqueti Neves A, Pfeifer D, Rawlins E, et al. The transcription factor GATA-3 controls cell fate and maintenance of type 2 innate lymphoid cells. Immunity. 2012;37:634-48 pubmed publisher
    ..Thus, our data demonstrate that GATA-3 is essential for ILC2 fate decisions and reveal similarities between the transcriptional programs controlling ILC and T helper cell fates. ..
  35. Krishnamoorthy V, Carr T, de Pooter R, Emanuelle A, Akinola E, Gounari F, et al. Repression of Ccr9 transcription in mouse T lymphocyte progenitors by the Notch signaling pathway. J Immunol. 2015;194:3191-200 pubmed publisher
    The chemokine receptor CCR9 controls the immigration of multipotent hematopoietic progenitor cells into the thymus to sustain T cell development...
  36. Wang C, Kang S, HogenEsch H, Love P, Kim C. Retinoic acid determines the precise tissue tropism of inflammatory Th17 cells in the intestine. J Immunol. 2010;184:5519-26 pubmed publisher
    ..The Th17 cells, induced in the presence or absence of RA, differentially expressed the trafficking receptors CCR9 and alpha4beta7...
  37. Lieberam I, Agalliu D, Nagasawa T, Ericson J, Jessell T. A Cxcl12-CXCR4 chemokine signaling pathway defines the initial trajectory of mammalian motor axons. Neuron. 2005;47:667-79 pubmed
    ..In its absence, these neurons adopt a dMN-like trajectory, despite preservation of their vMN transcriptional identity. Thus, the status of Cxcr4 signaling helps to determine the initial axonal trajectory of mammalian motor neurons. ..
  38. Desanti G, Jenkinson W, Parnell S, Boudil A, Gautreau Rolland L, Eksteen B, et al. Clonal analysis reveals uniformity in the molecular profile and lineage potential of CCR9(+) and CCR9(-) thymus-settling progenitors. J Immunol. 2011;186:5227-35 pubmed publisher
    ..Although multiple factors including the chemokine receptors CCR7 and CCR9 are now defined as important mediators of progenitor recruitment and colonization in both the fetal and adult thymi,..
  39. Lopez Pacheco C, Soldevila G, Du Pont G, Hernandez Pando R, Garcia Zepeda E. CCR9 Is a Key Regulator of Early Phases of Allergic Airway Inflammation. Mediators Inflamm. 2016;2016:3635809 pubmed
    ..Chemokine receptors involved in leukocyte recruitment are closely related to the pathology in asthma. CCR9 has been described as a homeostatic and inflammatory chemokine receptor, but its role and that of its ligand CCL25 ..
  40. Pabst O, Ohl L, Wendland M, Wurbel M, Kremmer E, Malissen B, et al. Chemokine receptor CCR9 contributes to the localization of plasma cells to the small intestine. J Exp Med. 2004;199:411-6 pubmed
    ..Using a newly generated monoclonal antibody against murine CCR9, we show that IgA+ PCs express high levels of CCR9 in the mesenteric lymph node (MLN) and Peyer's patches (PPs), ..
  41. Hadeiba H, Lahl K, Edalati A, Oderup C, Habtezion A, Pachynski R, et al. Plasmacytoid dendritic cells transport peripheral antigens to the thymus to promote central tolerance. Immunity. 2012;36:438-50 pubmed publisher
    ..Immature plasmacytoid DCs (pDCs) express CCR9, a chemokine receptor involved in migration of T cell precursors to the thymus...
  42. McGuire H, Vogelzang A, Ma C, Hughes W, Silveira P, Tangye S, et al. A subset of interleukin-21+ chemokine receptor CCR9+ T helper cells target accessory organs of the digestive system in autoimmunity. Immunity. 2011;34:602-15 pubmed publisher
    ..cell subset marked by coexpression of the cytokine interleukin 21 (IL-21) and the gut-homing chemokine receptor CCR9. Although CCR9+ Th cells were observed in healthy mice and humans, they were enriched in the inflamed pancreas and ..
  43. Lee H, Kim H, Lee E, Jang M, Kim S, Park J, et al. Characterization of CCR9 expression and thymus-expressed chemokine responsiveness of the murine thymus, spleen and mesenteric lymph node. Immunobiology. 2012;217:402-11 pubmed publisher
    CC chemokine receptor 9 (CCR9) is a receptor expressed at high levels in immature thymocytes, small intestine trafficking T cells and IgA-producing plasma cells...
  44. Ripen A, Nitta T, Murata S, Tanaka K, Takahama Y. Ontogeny of thymic cortical epithelial cells expressing the thymoproteasome subunit ?5t. Eur J Immunol. 2011;41:1278-87 pubmed publisher
    ..in Foxn1-deficient nude mice, although its expression was not reduced in mice deficient for both CCR7 and CCR9, in which fetal thymus colonization by leukocytes is defective...
  45. Chennupati V, Worbs T, Liu X, Malinarich F, Schmitz S, Haas J, et al. Intra- and intercompartmental movement of gammadelta T cells: intestinal intraepithelial and peripheral gammadelta T cells represent exclusive nonoverlapping populations with distinct migration characteristics. J Immunol. 2010;185:5160-8 pubmed publisher
    ..However, outside the intestinal epithelium, survival of ?? iIELs was very poor. In CCR9-deficient mice, homing of ?? iIELs was impaired, but did not lead to an accumulation of ?? iIEL-like cells in the ..
  46. Drakes M, Stiff P, Blanchard T. Inverse relationship between dendritic cell CCR9 expression and maturation state. Immunology. 2009;127:466-76 pubmed publisher
    b>CCR9 has been identified on T cells as a chemokine receptor that directs these cells to migrate to the intestine. CCR9 has also been reported on different cell types in the intestine, thymus, liver and peripheral blood...
  47. Benz C, Martins V, Radtke F, Bleul C. The stream of precursors that colonizes the thymus proceeds selectively through the early T lineage precursor stage of T cell development. J Exp Med. 2008;205:1187-99 pubmed publisher
    ..However, it is clear that of the known intrathymic precursors, only the ETP population contributes significant numbers of T lineage precursors to T cell development. ..
  48. Johansson Lindbom B, Svensson M, Pabst O, Palmqvist C, Marquez G, Forster R, et al. Functional specialization of gut CD103+ dendritic cells in the regulation of tissue-selective T cell homing. J Exp Med. 2005;202:1063-73 pubmed
    Gut-associated lymphoid tissue (GALT) dendritic cells (DCs) display a unique ability to generate CCR9+alpha4beta7+ gut-tropic CD8+ effector T cells...
  49. Evans Marin H, Cao A, Yao S, Chen F, He C, Liu H, et al. Unexpected Regulatory Role of CCR9 in Regulatory T Cell Development. PLoS ONE. 2015;10:e0134100 pubmed publisher
    ..b>CCR9, a gut-trophic chemokine receptor expressed by lymphocytes and dendritic cells, has been implicated in the ..
  50. Rezende R, da Cunha A, Kuhn C, Rubino S, M Hamdi H, Gabriely G, et al. Identification and characterization of latency-associated peptide-expressing γδ T cells. Nat Commun. 2015;6:8726 pubmed publisher
    ..Thymic CD27+IFN-γ+CCR9+α4β7+TCRγδ+ cells migrate to the periphery, particularly to Peyer's patches and small intestine lamina ..
  51. Xu Z, Mei F, Liu H, Sun C, Zheng Z. C-C Motif Chemokine Receptor 9 Exacerbates Pressure Overload-Induced Cardiac Hypertrophy and Dysfunction. J Am Heart Assoc. 2016;5: pubmed publisher
    ..C-C motif chemokine receptor 9 (CCR9), a subfamily of the G protein-coupled receptor supergene family, has been highlighted as an immunologic regulator ..