Gene Symbol: Ccr7
Description: chemokine (C-C motif) receptor 7
Alias: CC-CKR-7, CCR-7, CD197, Cdw197, Cmkbr7, EBI1, Ebi1h, C-C chemokine receptor type 7, EBV-induced G-protein coupled receptor 1, MIP-3 beta receptor, chemokine (C-C) receptor 7, epstein-Barr virus-induced G-protein coupled receptor 1
Species: mouse
Products:     Ccr7

Top Publications

  1. Schulz O, Jaensson E, Persson E, Liu X, Worbs T, Agace W, et al. Intestinal CD103+, but not CX3CR1+, antigen sampling cells migrate in lymph and serve classical dendritic cell functions. J Exp Med. 2009;206:3101-14 pubmed publisher
  2. Pahuja A, Maki R, Hevezi P, Chen A, Verge G, Lechner S, et al. Experimental autoimmune encephalomyelitis develops in CC chemokine receptor 7-deficient mice with altered T-cell responses. Scand J Immunol. 2006;64:361-9 pubmed
    CC chemokine receptor 7 (CCR7) is involved in the initiation of immune responses by mediating the migration of naïve T cells and mature dendritic cells to T-cell-rich zones of secondary lymphoid organs where antigen presentation occurs...
  3. Szanya V, Ermann J, Taylor C, Holness C, Fathman C. The subpopulation of CD4+CD25+ splenocytes that delays adoptive transfer of diabetes expresses L-selectin and high levels of CCR7. J Immunol. 2002;169:2461-5 pubmed
    ..We demonstrate that the CD4(+)CD25(+)CD62L(+) splenocytes express CCR7 at high levels and migrate toward secondary lymphoid tissue chemokine and ELC (macrophage-inflammatory protein-..
  4. Kocks J, Davalos Misslitz A, Hintzen G, Ohl L, Forster R. Regulatory T cells interfere with the development of bronchus-associated lymphoid tissue. J Exp Med. 2007;204:723-34 pubmed
    ..Here we demonstrate that mice deficient for the chemokine receptor CCR7 regularly develop highly organized BALT...
  5. Liu C, Saito F, Liu Z, Lei Y, Uehara S, Love P, et al. Coordination between CCR7- and CCR9-mediated chemokine signals in prevascular fetal thymus colonization. Blood. 2006;108:2531-9 pubmed
    ..Here we show that mice doubly deficient for chemokine receptors CCR7 and CCR9 were defective specifically in fetal thymus colonization before, but not after, thymus vascularization...
  6. Lei Y, Ripen A, Ishimaru N, Ohigashi I, Nagasawa T, Jeker L, et al. Aire-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell development. J Exp Med. 2011;208:383-94 pubmed publisher
    ..These results indicate that the XCL1-mediated medullary accumulation of tDCs contributes to nT reg cell development and is regulated by Aire. ..
  7. Vigl B, Aebischer D, Nitschké M, Iolyeva M, Röthlin T, Antsiferova O, et al. Tissue inflammation modulates gene expression of lymphatic endothelial cells and dendritic cell migration in a stimulus-dependent manner. Blood. 2011;118:205-15 pubmed publisher
    ..Although the requirement for CCR7 signaling became further pronounced during inflammation, CCR7-independent signals had an additional, albeit ..
  8. Mollah S, Dobrin J, Feder R, Tse S, Matos I, Cheong C, et al. Flt3L dependence helps define an uncharacterized subset of murine cutaneous dendritic cells. J Invest Dermatol. 2014;134:1265-1275 pubmed publisher
    ..Examination of DC capture of FITC from painted skin, DC isolation from skin explant culture, and from the skin of CCR7 knockout mice, which accumulate migDCs, demonstrate these cells are cutaneous residents...
  9. Xin H, Peng Y, Yuan Z, Guo H. In vitro maturation and migration of immature dendritic cells after chemokine receptor 7 transfection. Can J Microbiol. 2009;55:859-66 pubmed publisher
    Dendritic cells are specialized antigen-presenting cells that regulate immunity and tolerance. Chemokine receptor 7 (CCR7), which is expressed by mature dendritic cells, mediates the migration of the cells to secondary lymphoid organs and ..

More Information


  1. Unsoeld H, Mueller K, Schleicher U, Bogdan C, Zwirner J, Voehringer D, et al. Abrogation of CCL21 chemokine function by transgenic over-expression impairs T cell immunity to local infections. Int Immunol. 2007;19:1281-9 pubmed
    The CC chemokine receptor 7 (CCR7) and its two ligands, CCL21 and CCL19, play an important role in migration of immune cells to lymphoid tissue...
  2. Schneider M, Meingassner J, Lipp M, Moore H, Rot A. CCR7 is required for the in vivo function of CD4+ CD25+ regulatory T cells. J Exp Med. 2007;204:735-45 pubmed
    b>CCR7-mediated migration of naive T cells into the secondary lymphoid organs is a prerequisite for their encounter with mature dendritic cells, the productive presentation of cognate antigen, and consequent T cell proliferation and ..
  3. Zlotoff D, Sambandam A, Logan T, Bell J, Schwarz B, Bhandoola A. CCR7 and CCR9 together recruit hematopoietic progenitors to the adult thymus. Blood. 2010;115:1897-905 pubmed publisher
    ..Here we report that the chemokine receptor CCR7 is also required for efficient thymic settling...
  4. Höpken U, Winter S, Achtman A, Krüger K, Lipp M. CCR7 regulates lymphocyte egress and recirculation through body cavities. J Leukoc Biol. 2010;87:671-82 pubmed publisher
    ..Here, we demonstrate that the homeostatic chemokine receptor CCR7 regulates homeostatic recirculation of lymphocytes through body cavities...
  5. Friedman R, Jacobelli J, Krummel M. Surface-bound chemokines capture and prime T cells for synapse formation. Nat Immunol. 2006;7:1101-8 pubmed
    ..However, chemokine-tethered T cells were hyper-responsive to subsequent contacts with antigen-presenting cells. Thus, T cells are costimulated 'in trans' and sequentially after initial engagement with their chemokine-rich environment. ..
  6. Hardtke S, Ohl L, Forster R. Balanced expression of CXCR5 and CCR7 on follicular T helper cells determines their transient positioning to lymph node follicles and is essential for efficient B-cell help. Blood. 2005;106:1924-31 pubmed
    ..We show that expression of CXCR5 is indispensable for T cells to enter B-cell follicles, whereas expression of CCR7 provides a counteracting signal to retain activated T cells in the T-cell area...
  7. Britschgi M, Link A, Lissandrin T, Luther S. Dynamic modulation of CCR7 expression and function on naive T lymphocytes in vivo. J Immunol. 2008;181:7681-8 pubmed
    The chemokine receptor CCR7 is critical for the recirculation of naive T cells. It is required for T cell entry into secondary lymphoid organs (SLO) and for T cell motility and retention within these organs...
  8. Marsland B, Bättig P, Bauer M, Ruedl C, Lässing U, Beerli R, et al. CCL19 and CCL21 induce a potent proinflammatory differentiation program in licensed dendritic cells. Immunity. 2005;22:493-505 pubmed draining lymph nodes, but not resting steady-state DCs residing within lymph nodes, expressed high levels of CCR7 in vivo and responded to CCL19 with the production of proinflammatory cytokines...
  9. Kursar M, Höpken U, Koch M, Kohler A, Lipp M, Kaufmann S, et al. Differential requirements for the chemokine receptor CCR7 in T cell activation during Listeria monocytogenes infection. J Exp Med. 2005;201:1447-57 pubmed
    ..This contact is the result of highly coordinated migration processes, in which the chemokine receptor CCR7 and its ligands, CCL19 and CCL21, play a central role...
  10. Ekland E, Forster R, Lipp M, Cyster J. Requirements for follicular exclusion and competitive elimination of autoantigen-binding B cells. J Immunol. 2004;172:4700-8 pubmed
    ..b>CCR7 expression is required for follicular exclusion of anergic cells, although up-regulation of the receptor does not ..
  11. Kurobe H, Liu C, Ueno T, Saito F, Ohigashi I, Seach N, et al. CCR7-dependent cortex-to-medulla migration of positively selected thymocytes is essential for establishing central tolerance. Immunity. 2006;24:165-77 pubmed
    ..It was recently shown that a chemokine signal via CCR7 is essential for the cortex-to-medulla migration of positively selected thymocytes in the thymus...
  12. Debes G, Arnold C, Young A, Krautwald S, Lipp M, Hay J, et al. Chemokine receptor CCR7 required for T lymphocyte exit from peripheral tissues. Nat Immunol. 2005;6:889-94 pubmed
    ..T lymphocytes in the afferent lymph expressed functional chemokine receptor CCR7, and CCR7 was required for T lymphocyte exit from the skin...
  13. Misslitz A, Pabst O, Hintzen G, Ohl L, Kremmer E, Petrie H, et al. Thymic T cell development and progenitor localization depend on CCR7. J Exp Med. 2004;200:481-91 pubmed
    ..Here we show that CCR7-deficient mice are distinguished by a disturbed thymic architecture, impaired T cell development, and decreased ..
  14. Worbs T, Mempel T, Bölter J, von Andrian U, Forster R. CCR7 ligands stimulate the intranodal motility of T lymphocytes in vivo. J Exp Med. 2007;204:489-95 pubmed
    ..Applying intravital two-photon microscopy, we demonstrate that chemokine receptor CCR7 signaling enhances the intranodal motility of CD4(+) T cells...
  15. Höpken U, Achtman A, Krüger K, Lipp M. Distinct and overlapping roles of CXCR5 and CCR7 in B-1 cell homing and early immunity against bacterial pathogens. J Leukoc Biol. 2004;76:709-18 pubmed
    ..Here, we show markedly decreased B-1 B cell numbers in the peritoneal cavity of CXCR5-/- and CXCR5-/-CCR7-/- double-deficient mice paralleled by reduced antigen-induced phosphorylcholine-specific immunoglobulin (Ig)M ..
  16. Noor S, Habashy A, Nance J, Clark R, Nemati K, Carson M, et al. CCR7-dependent immunity during acute Toxoplasma gondii infection. Infect Immun. 2010;78:2257-63 pubmed publisher
    The chemokine receptor CCR7 is a well-established homing receptor for dendritic cells and T cells...
  17. Okada T, Cyster J. CC chemokine receptor 7 contributes to Gi-dependent T cell motility in the lymph node. J Immunol. 2007;178:2973-8 pubmed
    ..The chemokine CCL21, a ligand of CCR7, strongly induces chemokinesis in vitro, and T cell motility in LNs from CCR7 ligand-deficient plt/plt mice was ..
  18. Davalos Misslitz A, Rieckenberg J, Willenzon S, Worbs T, Kremmer E, Bernhardt G, et al. Generalized multi-organ autoimmunity in CCR7-deficient mice. Eur J Immunol. 2007;37:613-22 pubmed
    ..In the present study, we analyzed the influence of CCR7 signaling in the development of autoimmunity, because this chemokine receptor is essentially involved in the ..
  19. Forster R, Schubel A, Breitfeld D, Kremmer E, Renner Müller I, Wolf E, et al. CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs. Cell. 1999;99:23-33 pubmed
    ..Analyzing gene-targeted mice, we identified the chemokine receptor CCR7 as an important organizer of the primary immune response...
  20. Nitta T, Nitta S, Lei Y, Lipp M, Takahama Y. CCR7-mediated migration of developing thymocytes to the medulla is essential for negative selection to tissue-restricted antigens. Proc Natl Acad Sci U S A. 2009;106:17129-33 pubmed publisher
    ..b>CCR7 is pivotal for cortex-to-medulla migration of positively selected thymocytes, and CCR7-mediated migration to the ..
  21. Junt T, Scandella E, Forster R, Krebs P, Krautwald S, Lipp M, et al. Impact of CCR7 on priming and distribution of antiviral effector and memory CTL. J Immunol. 2004;173:6684-93 pubmed
    The chemokine receptor CCR7 is a key factor in the coordinate migration of T cells and dendritic cells (DC) into and their localization within secondary lymphoid organs...
  22. Ueno T, Saito F, Gray D, Kuse S, Hieshima K, Nakano H, et al. CCR7 signals are essential for cortex-medulla migration of developing thymocytes. J Exp Med. 2004;200:493-505 pubmed
    ..Here we show that in mice deficient for CCR7 or its ligands mature single-positive thymocytes are arrested in the cortex and do not accumulate in the medulla...
  23. Luther S, Ansel K, Cyster J. Overlapping roles of CXCL13, interleukin 7 receptor alpha, and CCR7 ligands in lymph node development. J Exp Med. 2003;197:1191-8 pubmed
    ..Using CXCL13-/- mice that additionally carry the paucity of LN T cell mutation (plt/plt), we discovered that CCR7 ligands function in peripheral LN development...
  24. Kuwabara T, Ishikawa F, Yasuda T, Aritomi K, Nakano H, Tanaka Y, et al. CCR7 ligands are required for development of experimental autoimmune encephalomyelitis through generating IL-23-dependent Th17 cells. J Immunol. 2009;183:2513-21 pubmed publisher
    ..C57BL/6 mice lacking expression of these chemokines (plt/plt mice) or their receptor CCR7 were resistant to EAE induced with myelin oligodendrocyte glycoprotein peptide 35-55 (MOG(35-55)) and pertussis ..
  25. Moschovakis G, Bubke A, Dittrich Breiholz O, Braun A, Prinz I, Kremmer E, et al. Deficient CCR7 signaling promotes TH2 polarization and B-cell activation in vivo. Eur J Immunol. 2012;42:48-57 pubmed publisher
    The chemokine receptor CCR7 has a central role in regulating homing and positioning of T cells and DCs to lymph nodes (LNs) and participates in T-cell development and activation...
  26. Kuwabara T, Tanaka Y, Ishikawa F, Kondo M, Sekiya H, Kakiuchi T. CCR7 ligands up-regulate IL-23 through PI3-kinase and NF-? B pathway in dendritic cells. J Leukoc Biol. 2012;92:309-18 pubmed publisher
    ..IL-23 is impaired in DCs from mice that lack expression of the chemokines CCL19 and CCL21, which share the receptor CCR7, suggesting that these chemokines are required for IL-23 expression...
  27. Weber M, Hauschild R, Schwarz J, Moussion C, de Vries I, Legler D, et al. Interstitial dendritic cell guidance by haptotactic chemokine gradients. Science. 2013;339:328-32 pubmed publisher
    ..These findings functionally establish the concept of haptotaxis, directed migration along immobilized gradients, in tissues. ..
  28. Huang J, Cardenas Navia L, Caldwell C, Plumb T, Radu C, Rocha P, et al. Requirements for T lymphocyte migration in explanted lymph nodes. J Immunol. 2007;178:7747-55 pubmed
    ..Although CCR7(-/-) naive T cells displayed a small reduction in locomotion, systemic treatment with pertussis toxin reduced naive ..
  29. Bai Z, Hayasaka H, Kobayashi M, Li W, Guo Z, Jang M, et al. CXC chemokine ligand 12 promotes CCR7-dependent naive T cell trafficking to lymph nodes and Peyer's patches. J Immunol. 2009;182:1287-95 pubmed
    ..In this study we report that CXCL12, acting through its receptor, CXCR4, cooperates with CCR7 ligands to promote T cell trafficking across HEVs...
  30. Pham T, Okada T, Matloubian M, Lo C, Cyster J. S1P1 receptor signaling overrides retention mediated by G alpha i-coupled receptors to promote T cell egress. Immunity. 2008;28:122-33 pubmed publisher
    ..Here, we showed that CCR7-deficient T cells left lymph nodes more rapidly than wild-type cells did, whereas CCR7-overexpressing cells were ..
  31. Braun A, Worbs T, Moschovakis G, Halle S, Hoffmann K, Bölter J, et al. Afferent lymph-derived T cells and DCs use different chemokine receptor CCR7-dependent routes for entry into the lymph node and intranodal migration. Nat Immunol. 2011;12:879-87 pubmed publisher
    ..Signals mediated by the chemokine receptor CCR7 were absolutely required for the directional migration of both DCs and T cells into the T cell zone but were ..
  32. Reinhardt A, Ravens S, Fleige H, Haas J, Oberdörfer L, Łyszkiewicz M, et al. CCR7-mediated migration in the thymus controls ?? T-cell development. Eur J Immunol. 2014;44:1320-9 pubmed publisher
    ..Here, we crossed C-C chemokine receptor (CCR)7-deficient (Ccr7(-/-) ) and CCR9-deficient mice (Ccr9(-/-) ) to mice with a TcrdH2BeGFP reporter background to investigate the ..
  33. Ueno T, Hara K, Willis M, Malin M, Höpken U, Gray D, et al. Role for CCR7 ligands in the emigration of newly generated T lymphocytes from the neonatal thymus. Immunity. 2002;16:205-18 pubmed
    ..Another CC chemokine CCL21, which shares CCR7 with CCL19 but has a unique C-terminal extension containing positively charged amino acids, failed to show ..
  34. Ohl L, Mohaupt M, Czeloth N, Hintzen G, Kiafard Z, Zwirner J, et al. CCR7 governs skin dendritic cell migration under inflammatory and steady-state conditions. Immunity. 2004;21:279-88 pubmed
    The CC chemokine receptor CCR7 has been identified as a key regulator of homeostatic B and T cell trafficking to secondary lymphoid organs...
  35. Okada T, Miller M, Parker I, Krummel M, Neighbors M, Hartley S, et al. Antigen-engaged B cells undergo chemotaxis toward the T zone and form motile conjugates with helper T cells. PLoS Biol. 2005;3:e150 pubmed
    ..that upon exposure to antigen, B cells migrate with directional preference toward the B-zone-T-zone boundary in a CCR7-dependent manner, through a region that exhibits a CCR7-ligand gradient...
  36. Menning A, Höpken U, Siegmund K, Lipp M, Hamann A, Huehn J. Distinctive role of CCR7 in migration and functional activity of naive- and effector/memory-like Treg subsets. Eur J Immunol. 2007;37:1575-83 pubmed
    ..The chemokine receptor CCR7 is expressed on both types of Treg subsets, albeit at different levels...
  37. Hintzen G, Ohl L, del Rio M, Rodriguez Barbosa J, Pabst O, Kocks J, et al. Induction of tolerance to innocuous inhaled antigen relies on a CCR7-dependent dendritic cell-mediated antigen transport to the bronchial lymph node. J Immunol. 2006;177:7346-54 pubmed
    ..In this study, we demonstrated that a CCR7-dependent migration of both CD103+ and CD103- lung dendritic cells (DC) to the bronchial lymph node (brLN) is ..
  38. Scimone M, Felbinger T, Mazo I, Stein J, von Andrian U, Weninger W. CXCL12 mediates CCR7-independent homing of central memory cells, but not naive T cells, in peripheral lymph nodes. J Exp Med. 2004;199:1113-20 pubmed
    ..Here, we report that T(CM), unlike naive T cells, can home to PLNs in both a CCR7-dependent and -independent manner...
  39. Stein J, Soriano S, M Rini C, Nombela Arrieta C, de Buitrago G, Rodríguez Frade J, et al. CCR7-mediated physiological lymphocyte homing involves activation of a tyrosine kinase pathway. Blood. 2003;101:38-44 pubmed
    ..The lymphocyte-expressed chemokine receptor CCR7 is playing an important role during this process, as its HEV-presented ligands CCL19 and CCL21 can trigger rapid ..
  40. Kawakami M, Narumoto O, Matsuo Y, Horiguchi K, Horiguchi S, Yamashita N, et al. The role of CCR7 in allergic airway inflammation induced by house dust mite exposure. Cell Immunol. 2012;275:24-32 pubmed publisher
    ..To clarify the process of sensitization, we investigated the role of the CCL21, CCL19, and CCR7 axis in a mouse model of HDM-induced allergic asthma...
  41. Sanchez Sanchez N, Riol Blanco L, Rodríguez Fernández J. The multiple personalities of the chemokine receptor CCR7 in dendritic cells. J Immunol. 2006;176:5153-9 pubmed
    b>CCR7 was described initially as a potent leukocyte chemotactic receptor that was later shown to be responsible of directing the migration of dendritic cells (DCs) to the lymph nodes where these cells play an important role in the ..
  42. Ehrlich L, Oh D, Weissman I, Lewis R. Differential contribution of chemotaxis and substrate restriction to segregation of immature and mature thymocytes. Immunity. 2009;31:986-98 pubmed publisher
    ..results revealed a requisite two-step process governing CD4 SP cell medullary localization: the chemokine receptor CCR7 mediated chemotaxis of CD4 SP cells towards medulla, whereas a distinct pertussis-toxin sensitive pathway was ..
  43. Johansson Lindbom B, Svensson M, Pabst O, Palmqvist C, Marquez G, Forster R, et al. Functional specialization of gut CD103+ dendritic cells in the regulation of tissue-selective T cell homing. J Exp Med. 2005;202:1063-73 pubmed
    ..CD103+ MLN DCs were reduced in number in CCR7-/- mice and, although CD8+ T cells proliferated in the MLNs of CCR7-/- mice after i.p...
  44. Höpken U, Droese J, Li J, Joergensen J, Breitfeld D, Zerwes H, et al. The chemokine receptor CCR7 controls lymph node-dependent cytotoxic T cell priming in alloimmune responses. Eur J Immunol. 2004;34:461-70 pubmed
    The chemokine receptor CCR7 and its ligands regulate migration and colocalization of T cells and mature dendritic cells to and within secondary lymphoid organs...
  45. Davalos Misslitz A, Worbs T, Willenzon S, Bernhardt G, Forster R. Impaired responsiveness to T-cell receptor stimulation and defective negative selection of thymocytes in CCR7-deficient mice. Blood. 2007;110:4351-9 pubmed
    The chemokine receptor CCR7 has been implicated in maintenance of thymus morphology and establishment of tolerance to self-antigens...
  46. Müller G, Höpken U, Lipp M. The impact of CCR7 and CXCR5 on lymphoid organ development and systemic immunity. Immunol Rev. 2003;195:117-35 pubmed
    ..Homeostatic chemokines, such as CXCL13, CCL21, and CCL19, as well as their corresponding receptors, CXCR5 and CCR7, have now been shown to closely cooperate in the development of lymphoid organs and the maintenance of lymphoid ..
  47. MartIn Fontecha A, Sebastiani S, Höpken U, Uguccioni M, Lipp M, Lanzavecchia A, et al. Regulation of dendritic cell migration to the draining lymph node: impact on T lymphocyte traffic and priming. J Exp Med. 2003;198:615-21 pubmed
    ..We found that the efficiency of DC migration varied with the number of injected DCs and that CCR7+/+ DCs migrating to the draining lymph node, but not CCR7-/- DCs that failed to do so, efficiently induced a rapid ..
  48. Ohl L, Henning G, Krautwald S, Lipp M, Hardtke S, Bernhardt G, et al. Cooperating mechanisms of CXCR5 and CCR7 in development and organization of secondary lymphoid organs. J Exp Med. 2003;197:1199-204 pubmed
    ..Mesenchymal cells also secrete CCL19, a ligand for CCR7, yet it is not clear whether CCR7 and CCL19 are important for secondary lymphoid organ development...
  49. Reif K, Ekland E, Ohl L, Nakano H, Lipp M, Forster R, et al. Balanced responsiveness to chemoattractants from adjacent zones determines B-cell position. Nature. 2002;416:94-9 pubmed
    ..Here we show that antigen-engaged B cells have increased expression of CCR7, the receptor for the T-zone chemokines CCL19 and CCL21, and that they exhibit increased responsiveness to both ..
  50. Nakamura K, White A, Parnell S, Lane P, Jenkinson E, Jenkinson W, et al. Differential requirement for CCR4 in the maintenance but not establishment of the invariant V?5(+) dendritic epidermal T-cell pool. PLoS ONE. 2013;8:e74019 pubmed publisher
    ..this process occurs independently of Aire's influences on intrathymic chemokines, and in the absence of CCR4 and CCR7 expression by DETC progenitors...
  51. Jang M, Sougawa N, Tanaka T, Hirata T, Hiroi T, Tohya K, et al. CCR7 is critically important for migration of dendritic cells in intestinal lamina propria to mesenteric lymph nodes. J Immunol. 2006;176:803-10 pubmed
    ..In this study we report that LP-DCs in unperturbed mice require CCR7 to migrate to MLNs...
  52. Ato M, Stager S, Engwerda C, Kaye P. Defective CCR7 expression on dendritic cells contributes to the development of visceral leishmaniasis. Nat Immunol. 2002;3:1185-91 pubmed
    ..localization was attributable to tumor necrosis factor-alpha-dependent, interleukin 10-mediated inhibition of CCR7 expression...
  53. Lämmermann T, Bader B, Monkley S, Worbs T, Wedlich Soldner R, Hirsch K, et al. Rapid leukocyte migration by integrin-independent flowing and squeezing. Nature. 2008;453:51-5 pubmed publisher
    ..Myosin II-dependent contraction is only required on passage through narrow gaps, where a squeezing contraction of the trailing edge propels the rigid nucleus. ..
  54. Forster R, Davalos Misslitz A, Rot A. CCR7 and its ligands: balancing immunity and tolerance. Nat Rev Immunol. 2008;8:362-71 pubmed publisher
    ..Recent evidence suggests that by guiding cells to and within lymphoid organs, CC-chemokine receptor 7 (CCR7) essentially contributes to both immunity and tolerance...
  55. Cyster J. Chemokines and cell migration in secondary lymphoid organs. Science. 1999;286:2098-102 pubmed
  56. Krueger A, Willenzon S, Lyszkiewicz M, Kremmer E, Forster R. CC chemokine receptor 7 and 9 double-deficient hematopoietic progenitors are severely impaired in seeding the adult thymus. Blood. 2010;115:1906-12 pubmed publisher
    ..To this end, we generated mice deficient in both CCR9 and CCR7. Deficiency in both chemokine receptors resulted in severely reduced numbers of early T-cell progenitors and in ..
  57. Kocks J, Adler H, Danzer H, Hoffmann K, Jonigk D, Lehmann U, et al. Chemokine receptor CCR7 contributes to a rapid and efficient clearance of lytic murine gamma-herpes virus 68 from the lung, whereas bronchus-associated lymphoid tissue harbors virus during latency. J Immunol. 2009;182:6861-9 pubmed publisher
    ..By intranasally infecting wild-type and CCR7-deficient mice, we investigated whether CCR7 is necessary for viral clearance from the lung and the establishment ..
  58. Pabst O, Herbrand H, Friedrichsen M, Velaga S, Dorsch M, Berhardt G, et al. Adaptation of solitary intestinal lymphoid tissue in response to microbiota and chemokine receptor CCR7 signaling. J Immunol. 2006;177:6824-32 pubmed
    ..In this study, we report that in chemokine receptor CCR7-deficient mice SILT is enlarged, although unchanged in frequency and cellular composition compared with wild-type ..
  59. Sakai N, Wada T, Yokoyama H, Lipp M, Ueha S, Matsushima K, et al. Secondary lymphoid tissue chemokine (SLC/CCL21)/CCR7 signaling regulates fibrocytes in renal fibrosis. Proc Natl Acad Sci U S A. 2006;103:14098-103 pubmed
    ..We hypothesized that CCR7-positive fibrocytes migrate into the kidney in response to secondary lymphoid tissue chemokine (SLC/CCL21) and ..
  60. Ledgerwood L, Lal G, Zhang N, Garin A, Esses S, Ginhoux F, et al. The sphingosine 1-phosphate receptor 1 causes tissue retention by inhibiting the entry of peripheral tissue T lymphocytes into afferent lymphatics. Nat Immunol. 2008;9:42-53 pubmed
    ..Thus, the increased sphingosine 1-phosphate present in inflamed peripheral tissues may induce T cell retention and suppress T cell egress. ..
  61. Beauvillain C, Cunin P, Doni A, Scotet M, Jaillon S, Loiry M, et al. CCR7 is involved in the migration of neutrophils to lymph nodes. Blood. 2011;117:1196-204 pubmed publisher
    ..We demonstrate that a subpopulation of human and mouse neutrophils express CCR7. CCR7 is rapidly expressed at the membrane upon stimulation...
  62. Seth S, Oberdörfer L, Hyde R, Hoff K, Thies V, Worbs T, et al. CCR7 essentially contributes to the homing of plasmacytoid dendritic cells to lymph nodes under steady-state as well as inflammatory conditions. J Immunol. 2011;186:3364-72 pubmed publisher
    The chemokine receptor CCR7 represents an important determinant for circulating lymphocytes to enter lymph nodes (LN) via high endothelial venules...
  63. Calderón L, Boehm T. Three chemokine receptors cooperatively regulate homing of hematopoietic progenitors to the embryonic mouse thymus. Proc Natl Acad Sci U S A. 2011;108:7517-22 pubmed publisher
    ..three of the chemokine receptor genes, chemokine (C-C motif) receptor 9 (Ccr9), chemokine (C-C motif) receptor 7 (Ccr7), and chemokine (C-X-C motif) receptor 4 (Cxcr4)...
  64. Trogan E, Feig J, Dogan S, Rothblat G, Angeli V, Tacke F, et al. Gene expression changes in foam cells and the role of chemokine receptor CCR7 during atherosclerosis regression in ApoE-deficient mice. Proc Natl Acad Sci U S A. 2006;103:3781-6 pubmed
    ..or apoE-/- recipient samples, but there was induction at the mRNA and protein levels of chemokine receptor CCR7, an essential factor for dendritic cell migration...