Ccr5

Summary

Gene Symbol: Ccr5
Description: chemokine (C-C motif) receptor 5
Alias: AM4-7, CD195, Cmkbr5, C-C chemokine receptor type 5, C-C CKR-5, CC-CKR-5, CCR-5, MIP-1 alpha receptor, chemokine (C-C) receptor 5
Species: mouse
Products:     Ccr5

Top Publications

  1. Yuan Q, Bromley S, Means T, Jones K, Hayashi F, Bhan A, et al. CCR4-dependent regulatory T cell function in inflammatory bowel disease. J Exp Med. 2007;204:1327-34 pubmed
    ..Our study demonstrates that CCR4 plays an important role in T reg cell trafficking in LNs and that this is critical for T reg cell suppressive function in vivo. ..
  2. Moreno C, Gustot T, Nicaise C, Quertinmont E, Nagy N, Parmentier M, et al. CCR5 deficiency exacerbates T-cell-mediated hepatitis in mice. Hepatology. 2005;42:854-62 pubmed
    ..Because the chemokine receptor CCR5 and its ligands (CCL3, CCL4, and CCL5) regulate leukocyte chemotaxis and activation, we investigated the role of ..
  3. Duan R, Chen Z, Bao L, Quezada H, Nennesmo I, Winblad B, et al. CCR5 deficiency does not prevent P0 peptide 180-199 immunized mice from experimental autoimmune neuritis. Neurobiol Dis. 2004;16:630-7 pubmed
    ..To explore the role of CC chemokine receptor 5 (CCR5) in the inflammatory process of EAN, we induced EAN in CCR5-deficient (CCR5(-/-)) mice with P0 protein peptide 180-..
  4. Kohlmeier J, Miller S, Smith J, Lu B, Gerard C, Cookenham T, et al. The chemokine receptor CCR5 plays a key role in the early memory CD8+ T cell response to respiratory virus infections. Immunity. 2008;29:101-13 pubmed publisher
    ..In this study, we demonstrate a crucial role for C-C chemokine receptor 5 (CCR5) in the accelerated recruitment of memory CD8(+) T cells to the lung airways during virus challenge...
  5. Kohlmeier J, Cookenham T, Miller S, Roberts A, Christensen J, Thomsen A, et al. CXCR3 directs antigen-specific effector CD4+ T cell migration to the lung during parainfluenza virus infection. J Immunol. 2009;183:4378-84 pubmed publisher
    ..Although it was previously reported that the chemokine receptors CCR5 and CXCR3 affect trafficking of respiratory virus-specific CD8+ T cells, it is unclear whether these receptors ..
  6. Carr D, Ash J, Lane T, Kuziel W. Abnormal immune response of CCR5-deficient mice to ocular infection with herpes simplex virus type 1. J Gen Virol. 2006;87:489-99 pubmed
    ..response that is associated with production of the beta chemokines CCL3 and CCL5, which share a common receptor, CCR5. To gain insight into the role of these molecules in ocular immune responses, the corneas of wild-type (WT) and ..
  7. Hugues S, Scholer A, Boissonnas A, Nussbaum A, Combadiere C, Amigorena S, et al. Dynamic imaging of chemokine-dependent CD8+ T cell help for CD8+ T cell responses. Nat Immunol. 2007;8:921-30 pubmed
    ..These antigen-independent interactions required expression of the chemokine receptor CCR5 on polyclonal T cells and increased the efficiency of the induction of naive, low-precursor-frequency CD8(+) T cell ..
  8. Ishida Y, Kimura A, Kondo T, Hayashi T, Ueno M, Takakura N, et al. Essential roles of the CC chemokine ligand 3-CC chemokine receptor 5 axis in bleomycin-induced pulmonary fibrosis through regulation of macrophage and fibrocyte infiltration. Am J Pathol. 2007;170:843-54 pubmed
    ..investigated the pathogenic roles of CC chemokine ligand (CCL)3 and its receptors, CC chemokine receptor (CCR)1 and CCR5, in bleomycin (BLM)-induced pulmonary fibrosis (PF)...
  9. Sato N, Kuziel W, Melby P, Reddick R, Kostecki V, Zhao W, et al. Defects in the generation of IFN-gamma are overcome to control infection with Leishmania donovani in CC chemokine receptor (CCR) 5-, macrophage inflammatory protein-1 alpha-, or CCR2-deficient mice. J Immunol. 1999;163:5519-25 pubmed
    We investigated the immune responses in mice lacking CCR2, CCR5, or macrophage inflammatory protein-1 alpha (MIP-1 alpha), a ligand for CCR5, in two situations: following T cell stimulation or after challenge with Leishmania donovani, an ..

More Information

Publications65

  1. Braunersreuther V, Zernecke A, Arnaud C, Liehn E, Steffens S, Shagdarsuren E, et al. Ccr5 but not Ccr1 deficiency reduces development of diet-induced atherosclerosis in mice. Arterioscler Thromb Vasc Biol. 2007;27:373-9 pubmed
    ..The CC-chemokine receptors 1 (CCR1) and 5 (CCR5) expressed on these cells bind chemokines implicated in atherosclerosis, namely CCL5/RANTES...
  2. Rahbar R, Murooka T, Fish E. Role for CCR5 in dissemination of vaccinia virus in vivo. J Virol. 2009;83:2226-36 pubmed publisher
    In an earlier report, we provided evidence that expression of CCR5 by primary human T cells renders them permissive for vaccinia virus (VACV) replication. This may represent a mechanism for dissemination throughout the lymphatic system...
  3. Hickman H, Li L, Reynoso G, Rubin E, Skon C, Mays J, et al. Chemokines control naive CD8+ T cell selection of optimal lymph node antigen presenting cells. J Exp Med. 2011;208:2511-24 pubmed publisher
    ..VV infection induces rapid release of CCR5-binding chemokines in the LN, and administration of chemokine-neutralizing antibodies diminishes T cell activation ..
  4. Ambati B, Anand A, Joussen A, Kuziel W, Adamis A, Ambati J. Sustained inhibition of corneal neovascularization by genetic ablation of CCR5. Invest Ophthalmol Vis Sci. 2003;44:590-3 pubmed
    To determine whether genetic ablation of the CC chemokine receptor CCR5 (involved in leukocyte and endothelial chemotaxis) inhibits the development of corneal neovascularization...
  5. Holst P, Orskov C, Qvortrup K, Christensen J, Thomsen A. CCR5 and CXCR3 are dispensable for liver infiltration, but CCR5 protects against virus-induced T-cell-mediated hepatic steatosis. J Virol. 2007;81:10101-12 pubmed
    b>CCR5 and CXCR3 are important molecules in regulating the migration of activated lymphocytes...
  6. Ng Cashin J, Kuhns J, Burkett S, Powderly J, Craven R, van Deventer H, et al. Host absence of CCR5 potentiates dendritic cell vaccination. J Immunol. 2003;170:4201-8 pubmed
    ..of this, we used a murine melanoma system and knockout mice to investigate the function of the chemokine receptor CCR5 and its ligands, CCR ligand (CCL)3 and CCL5...
  7. Thapa M, Kuziel W, Carr D. Susceptibility of CCR5-deficient mice to genital herpes simplex virus type 2 is linked to NK cell mobilization. J Virol. 2007;81:3704-13 pubmed
    ..The present investigation sought to determine the role of the chemokine receptor CCR5 in this process...
  8. Sato N, Ahuja S, Quinones M, Kostecki V, Reddick R, Melby P, et al. CC chemokine receptor (CCR)2 is required for langerhans cell migration and localization of T helper cell type 1 (Th1)-inducing dendritic cells. Absence of CCR2 shifts the Leishmania major-resistant phenotype to a susceptible state dominated by Th2 cy. J Exp Med. 2000;192:205-18 pubmed
    ..We tested the hypothesis that the CC chemokine receptor (CCR)2 and CCR5 and the chemokine macrophage inflammatory protein (MIP)-1alpha, a ligand for CCR5, influence DC migration and ..
  9. Weiss I, Shoham H, Wald O, Wald H, Beider K, Abraham M, et al. Ccr5 deficiency regulates the proliferation and trafficking of natural killer cells under physiological conditions. Cytokine. 2011;54:249-57 pubmed publisher
    ..We report here that under physiological conditions, the bone marrow (BM), spleen, blood and liver of Ccr5, but not of Ccr1-deficient mice, contain reduced numbers of NK cells...
  10. Algood H, Flynn J. CCR5-deficient mice control Mycobacterium tuberculosis infection despite increased pulmonary lymphocytic infiltration. J Immunol. 2004;173:3287-96 pubmed
    ..infection causes an increase in the expression of beta-chemokines CCL3, CCL4, and CCL5, and their receptor CCR5, in the lungs...
  11. Yurchenko E, Tritt M, Hay V, Shevach E, Belkaid Y, Piccirillo C. CCR5-dependent homing of naturally occurring CD4+ regulatory T cells to sites of Leishmania major infection favors pathogen persistence. J Exp Med. 2006;203:2451-60 pubmed
    ..of infection and show that CD4+CD25+ nTreg cells, compared with normal CD4+ T cells, preferentially express the CCR5 chemokine receptor, which enables them to migrate in response to CCR5 ligands in vitro...
  12. Zhong M, Kuziel W, Pamer E, Serbina N. Chemokine receptor 5 is dispensable for innate and adaptive immune responses to Listeria monocytogenes infection. Infect Immun. 2004;72:1057-64 pubmed
    Chemokine receptor 5 (CCR5) binds macrophage inflammatory protein 1alpha (MIP-1alpha), MIP-1beta, RANTES, and members of the monocyte chemotactic protein family and is also a receptor for human immunodeficiency virus (HIV)...
  13. Scanga C, Aliberti J, Jankovic D, Tilloy F, Bennouna S, Denkers E, et al. Cutting edge: MyD88 is required for resistance to Toxoplasma gondii infection and regulates parasite-induced IL-12 production by dendritic cells. J Immunol. 2002;168:5997-6001 pubmed
    ..Taken together, these data suggest that the induction of IL-12 by T. gondii depends on a unique mechanism involving both MyD88 and G protein-coupled signaling pathways. ..
  14. Andres P, Beck P, Mizoguchi E, Mizoguchi A, Bhan A, Dawson T, et al. Mice with a selective deletion of the CC chemokine receptors 5 or 2 are protected from dextran sodium sulfate-mediated colitis: lack of CC chemokine receptor 5 expression results in a NK1.1+ lymphocyte-associated Th2-type immune response in the intes. J Immunol. 2000;164:6303-12 pubmed
    The chemokine receptors CCR2 and CCR5 and their respective ligands regulate leukocyte chemotaxis and activation...
  15. de Lemos C, Christensen J, Nansen A, Moos T, Lu B, Gerard C, et al. Opposing effects of CXCR3 and CCR5 deficiency on CD8+ T cell-mediated inflammation in the central nervous system of virus-infected mice. J Immunol. 2005;175:1767-75 pubmed
    ..To study the redundancy of the chemokine receptors CXCR3 and CCR5 in regulating virus-induced CD8+ T cell-mediated inflammation in the brain, CXCR3/CCR5 double-deficient mice were ..
  16. Yahiaoui L, Gvozdic D, Danialou G, Mack M, Petrof B. CC family chemokines directly regulate myoblast responses to skeletal muscle injury. J Physiol. 2008;586:3991-4004 pubmed publisher
    ..were specifically inhibited by antibodies directed against CC family chemokine receptors 2 and 5 (CCR2 and CCR5)...
  17. Tan M, Goedegebuure P, Belt B, Flaherty B, Sankpal N, Gillanders W, et al. Disruption of CCR5-dependent homing of regulatory T cells inhibits tumor growth in a murine model of pancreatic cancer. J Immunol. 2009;182:1746-55 pubmed
    ..and a murine pancreatic tumor model (Pan02), that tumor cells produce increased levels of ligands for the CCR5 chemokine receptor and, reciprocally, that CD4(+) Foxp3(+) Tregs, compared with CD4(+) Foxp3(-) effector T cells, ..
  18. Ank N, Petersen K, Malmgaard L, Mogensen S, Paludan S. Age-dependent role for CCR5 in antiviral host defense against herpes simplex virus type 2. J Virol. 2005;79:9831-41 pubmed
    ..In this study we have studied the role of CC chemokine receptor 1 (CCR1) and CCR5 in host defense during a generalized herpes simplex virus type 2 (HSV-2) infection...
  19. Dawson T, Beck M, Kuziel W, Henderson F, Maeda N. Contrasting effects of CCR5 and CCR2 deficiency in the pulmonary inflammatory response to influenza A virus. Am J Pathol. 2000;156:1951-9 pubmed
    ..CC chemokine receptors CCR5 and CCR2 are both expressed on activated macrophages and T cells...
  20. Warren G, O farrell L, Summan M, Hulderman T, Mishra D, Luster M, et al. Role of CC chemokines in skeletal muscle functional restoration after injury. Am J Physiol Cell Physiol. 2004;286:C1031-6 pubmed
    ..protein (MIP)-1alpha, MIP-1beta, and monocyte chemoattractant protein (MCP)-1 as well as their major receptors, CCR5 and CCR2, increased after freeze injury and gradually returned to control (uninjured) levels by 14 days...
  21. Peterson K, Errett J, Wei T, Dimcheff D, Ransohoff R, Kuziel W, et al. MCP-1 and CCR2 contribute to non-lymphocyte-mediated brain disease induced by Fr98 polytropic retrovirus infection in mice: role for astrocytes in retroviral neuropathogenesis. J Virol. 2004;78:6449-58 pubmed
    ..neurological disease and causes the upregulation of several chemokines that bind to chemokine receptors CCR2 and CCR5. Knockout mice deficient in CCR2 had reduced susceptibility to Fr98 pathogenesis, with significantly fewer mice ..
  22. Aliberti J, Valenzuela J, Carruthers V, Hieny S, Andersen J, Charest H, et al. Molecular mimicry of a CCR5 binding-domain in the microbial activation of dendritic cells. Nat Immunol. 2003;4:485-90 pubmed
    ..Recombinant C-18 showed high affinity for and triggered cell signaling through CCR5, a chemokine receptor important in parasite-induced IL-12 production by DCs...
  23. Fadel S, Bromley S, Medoff B, Luster A. CXCR3-deficiency protects influenza-infected CCR5-deficient mice from mortality. Eur J Immunol. 2008;38:3376-87 pubmed publisher
    Mice lacking the chemokine receptor CCR5 are susceptible to mortality from a normally non-lethal influenza infection. Here we found that CXCR3-deficiency rescued CCR5-deficient (CCR5(-/-)) mice from influenza-induced mortality...
  24. Moreira A, Cavassani K, Massafera Tristão F, Campanelli A, Martinez R, Rossi M, et al. CCR5-dependent regulatory T cell migration mediates fungal survival and severe immunosuppression. J Immunol. 2008;180:3049-56 pubmed
    ..paracoccidioidomycosis, the migration of Treg cells is dependent on the axis chemokine-chemokine receptors, and CCR5 ligands are produced in P...
  25. Cheng J, Sung R. CC Chemokine receptor 5 deficiency does not prevent local immune responses to adenovirus vector in islet transplant recipients. J Surg Res. 2012;174:166-75 pubmed publisher
    CC chemokine receptor 5 (CCR5) plays an important role in mediating inflammation. We examined the effect of CCR5 on the immune response to adenovirus vectors and graft function in islet transplant model...
  26. Chiu B, Freeman C, Stolberg V, Hu J, Zeibecoglou K, Lu B, et al. Impaired lung dendritic cell activation in CCR2 knockout mice. Am J Pathol. 2004;165:1199-209 pubmed
    ..To determine the role of chemokines in DC mobilization, we applied this analysis to CCR1, CCR2, CCR5, and CCR6 chemokine receptor knockout mice...
  27. Zhou Y, Kurihara T, Ryseck R, Yang Y, Ryan C, Loy J, et al. Impaired macrophage function and enhanced T cell-dependent immune response in mice lacking CCR5, the mouse homologue of the major HIV-1 coreceptor. J Immunol. 1998;160:4018-25 pubmed
    The CC-chemokine receptor CCR5 has been shown to be the major coreceptor for HIV-1 entry into cells, and humans with homozygous mutation in the ccr5 gene are highly resistant to HIV-1 infection, despite the existence of many other HIV-1 ..
  28. Tacke F, Alvarez D, Kaplan T, Jakubzick C, Spanbroek R, Llodra J, et al. Monocyte subsets differentially employ CCR2, CCR5, and CX3CR1 to accumulate within atherosclerotic plaques. J Clin Invest. 2007;117:185-94 pubmed
    ..CCR2(-) monocytes did not rely on CX3CR1 to enter plaques. Instead, they were partially dependent upon CCR5, which they selectively upregulated in apoE(-/-) mice...
  29. Glass W, Lane T. Functional analysis of the CC chemokine receptor 5 (CCR5) on virus-specific CD8+ T cells following coronavirus infection of the central nervous system. Virology. 2003;312:407-14 pubmed
    ..The present study evaluated the contributions of CCR5 to the activation and trafficking of virus-specific CD8(+) T cells into the MHV-infected CNS mice...
  30. Schlecker E, Stojanovic A, Eisen C, Quack C, Falk C, Umansky V, et al. Tumor-infiltrating monocytic myeloid-derived suppressor cells mediate CCR5-dependent recruitment of regulatory T cells favoring tumor growth. J Immunol. 2012;189:5602-11 pubmed publisher
    ..not only produced high levels of NO and arginase-1, but also greatly increased levels of chemokines comprising the CCR5 ligands CCL3, CCL4, and CCL5...
  31. Khan I, Thomas S, Moretto M, Lee F, Islam S, Combe C, et al. CCR5 is essential for NK cell trafficking and host survival following Toxoplasma gondii infection. PLoS Pathog. 2006;2:e49 pubmed
    ..We analyzed the host response of mice deficient in the chemokine receptor CCR5 following infection with the intracellular protozoan parasite Toxoplasma gondii...
  32. Murai M, Yoneyama H, Ezaki T, Suematsu M, Terashima Y, Harada A, et al. Peyer's patch is the essential site in initiating murine acute and lethal graft-versus-host reaction. Nat Immunol. 2003;4:154-60 pubmed
    ..when recruitment of donor T cells into PP was interrupted either by disrupting the gene encoding chemokine receptor CCR5 or by blocking integrin alpha(4)beta(7)-MAdCAM-1 (mucosal vascular addressin) interactions...
  33. Gregg R, Nichols L, Chen Y, Lu B, Engelhard V. Mechanisms of spatial and temporal development of autoimmune vitiligo in tyrosinase-specific TCR transgenic mice. J Immunol. 2010;184:1909-17 pubmed publisher
    ..Disease is strongly dependent on both IFN-gamma and CXCR3, whereas dependence on CCR5 is more limited, and both CCR4 and perforin are dispensable...
  34. Kohlmeier J, Reiley W, Perona Wright G, Freeman M, Yager E, Connor L, et al. Inflammatory chemokine receptors regulate CD8(+) T cell contraction and memory generation following infection. J Exp Med. 2011;208:1621-34 pubmed publisher
    ..In this study, we describe a novel role for the chemokine receptors CCR5 and CXCR3 in regulating effector CD8(+) T cell contraction and memory generation after influenza virus infection...
  35. Tyner J, Uchida O, Kajiwara N, Kim E, Patel A, O Sullivan M, et al. CCL5-CCR5 interaction provides antiapoptotic signals for macrophage survival during viral infection. Nat Med. 2005;11:1180-7 pubmed
    ..The protective effect of Ccl5 requires activation of the Ccr5 chemokine receptor and consequent bilateral activation of G(alphai)-PI3K-AKT and G(alphai)-MEK-ERK signaling ..
  36. Chantakru S, Kuziel W, Maeda N, Croy B. A study on the density and distribution of uterine Natural Killer cells at mid pregnancy in mice genetically-ablated for CCR2, CCR 5 and the CCR5 receptor ligand, MIP-1 alpha. J Reprod Immunol. 2001;49:33-47 pubmed
    ..Peripheral NK cells express the CC-chemokine receptor CCR2, for MCP-1 and CCR5, for MIP-1 alpha and RANTES...
  37. Glass W, Lim J, Cholera R, Pletnev A, Gao J, Murphy P. Chemokine receptor CCR5 promotes leukocyte trafficking to the brain and survival in West Nile virus infection. J Exp Med. 2005;202:1087-98 pubmed
    ..Central nervous system (CNS) expression of the chemokine receptor CCR5 and its ligand CCL5 was prominently up-regulated by WNV, and this was associated with CNS infiltration of CD4+ and ..
  38. Nansen A, Christensen J, Andreasen S, Bartholdy C, Christensen J, Thomsen A. The role of CC chemokine receptor 5 in antiviral immunity. Blood. 2002;99:1237-45 pubmed
    The CC chemokine receptor CCR5 is an important coreceptor for human immunodeficiency virus (HIV), and there is a major thrust to develop anti-CCR5-based therapies for HIV-1...
  39. Belnoue E, Kayibanda M, Deschemin J, Viguier M, Mack M, Kuziel W, et al. CCR5 deficiency decreases susceptibility to experimental cerebral malaria. Blood. 2003;101:4253-9 pubmed
    ..Chemokine receptor-5 (CCR5) is an important regulator of leukocyte trafficking in the brain in response to fungal and viral infection...
  40. Castellino F, Huang A, Altan Bonnet G, Stoll S, Scheinecker C, Germain R. Chemokines enhance immunity by guiding naive CD8+ T cells to sites of CD4+ T cell-dendritic cell interaction. Nature. 2006;440:890-5 pubmed
    ..before antigen recognition, naive CD8+ T cells in immunogen-draining lymph nodes upregulate the chemokine receptor CCR5, permitting these cells to be attracted to sites of antigen-specific dendritic cell-CD4+ T cell interaction where ..
  41. Olive A, Gondek D, Starnbach M. CXCR3 and CCR5 are both required for T cell-mediated protection against C. trachomatis infection in the murine genital mucosa. Mucosal Immunol. 2011;4:208-16 pubmed publisher
    ..In this study we identify that the chemokine receptors CXCR3 (chemokine (C-X-C motif) receptor 3) and CCR5 (chemokine (C-C motif) receptor 5) are pivotal for T-lymphocyte access to the genital tract during Chlamydia ..
  42. Huffnagle G, McNeil L, McDonald R, Murphy J, Toews G, Maeda N, et al. Cutting edge: Role of C-C chemokine receptor 5 in organ-specific and innate immunity to Cryptococcus neoformans. J Immunol. 1999;163:4642-6 pubmed
    ..intratracheal inoculation of the AIDS-associated pathogen Cryptococcus neoformans, 12-wk survival was >90% for CCR5+/+ mice but <25% for CCR5-/- mice...
  43. Ishida Y, Kimura A, Kuninaka Y, Inui M, Matsushima K, Mukaida N, et al. Pivotal role of the CCL5/CCR5 interaction for recruitment of endothelial progenitor cells in mouse wound healing. J Clin Invest. 2012;122:711-21 pubmed publisher
    ..Here we show in mice that the absence of CCR5 reduced vascular EPC accumulation and neovascularization, but not macrophage recruitment, and eventually delayed ..
  44. Hardison J, Wrightsman R, Carpenter P, Kuziel W, Lane T, Manning J. The CC chemokine receptor 5 is important in control of parasite replication and acute cardiac inflammation following infection with Trypanosoma cruzi. Infect Immun. 2006;74:135-43 pubmed
    ..CC chemokine receptor 5 (CCR5) is prominently expressed during both acute and chronic disease, suggesting a role in regulating leukocyte ..
  45. Wysocki C, Jiang Q, Panoskaltsis Mortari A, Taylor P, McKinnon K, Su L, et al. Critical role for CCR5 in the function of donor CD4+CD25+ regulatory T cells during acute graft-versus-host disease. Blood. 2005;106:3300-7 pubmed
    ..Here, we demonstrate that T(regs) lacking expression of the chemokine receptor CCR5 were far less effective in preventing lethality from GVHD...
  46. Zhao X, Sato A, Dela Cruz C, Linehan M, Luegering A, Kucharzik T, et al. CCL9 is secreted by the follicle-associated epithelium and recruits dome region Peyer's patch CD11b+ dendritic cells. J Immunol. 2003;171:2797-803 pubmed
    ..Taken together, these results demonstrate an important role of CCL9 in CD11b(+) DC recruitment to the dome regions of mouse Peyer's patches. ..
  47. Kuziel W, Dawson T, Quinones M, Garavito E, Chenaux G, Ahuja S, et al. CCR5 deficiency is not protective in the early stages of atherogenesis in apoE knockout mice. Atherosclerosis. 2003;167:25-32 pubmed
    ..A possible role for the chemokine receptor CCR5 in atherogenesis has been suggested by CCR5 expression on macrophages, T cells, coronary endothelial cells and ..
  48. Komatsu K, Miyazaki D, Morohoshi K, Kuo C, Kakimaru Hasegawa A, Komatsu N, et al. Pathogenesis of herpetic stromal keratitis in CCR5- and/or CXCR3-deficient mice. Curr Eye Res. 2008;33:736-49 pubmed publisher
    ..In this study, we have focused on two chemokine receptors, CCR5 and CXCR3, which are expressed on CD4+ Th1 cells in mice HSK model...
  49. Souza A, Souza P, Pereira C, Fernandes A, Guabiraba R, Russo R, et al. Experimental infection with Schistosoma mansoni in CCR5-deficient mice is associated with increased disease severity, as CCR5 plays a role in controlling granulomatous inflammation. Infect Immun. 2011;79:1741-9 pubmed publisher
    ..during schistosomiasis mansoni infection, we evaluated the course of infection in C57BL/6J mice deficient in CCR5, one of the receptors for CCL3...
  50. Ajuebor M, Aspinall A, Zhou F, Le T, Yang Y, Urbanski S, et al. Lack of chemokine receptor CCR5 promotes murine fulminant liver failure by preventing the apoptosis of activated CD1d-restricted NKT cells. J Immunol. 2005;174:8027-37 pubmed
    ..The etiology of FLF remains undefined. In this study, we demonstrate that CCR5 deficiency promotes the development of acute FLF in mice following Con A administration by preventing activated ..
  51. Bierly A, Shufesky W, Sukhumavasi W, Morelli A, Denkers E. Dendritic cells expressing plasmacytoid marker PDCA-1 are Trojan horses during Toxoplasma gondii infection. J Immunol. 2008;181:8485-91 pubmed
    ..We hypothesize that Toxoplasma exploits pDCs as Trojan horses, targeting them for early infection, suppressing their cytokine effector function, and using them for dissemination within the host. ..
  52. MacTaggart J, Xiong W, Knispel R, Baxter B. Deletion of CCR2 but not CCR5 or CXCR3 inhibits aortic aneurysm formation. Surgery. 2007;142:284-8 pubmed
    ..The chemokine receptors CCR2, CCR5, and CXCR3 are associated with pathways implicated previously in aneurysm pathogenesis...
  53. Gu S, Park M, Yun H, Han S, Oh K, Son D, et al. CCR5 knockout suppresses experimental autoimmune encephalomyelitis in C57BL/6 mice. Oncotarget. 2016;7:15382-93 pubmed publisher
    ..C-C chemokine receptor type 5 (CCR5) is implicated in immune cell migration and cytokine release in central nervous system (CNS)...
  54. Wu Y, Li Y, Matsushima K, Baba T, Mukaida N. CCL3-CCR5 axis regulates intratumoral accumulation of leukocytes and fibroblasts and promotes angiogenesis in murine lung metastasis process. J Immunol. 2008;181:6384-93 pubmed
    ..in infiltrating cells and, to a lesser degree, tumor cells, together with an infiltration of leukocytes expressing CCR5, a specific receptor for CCL3...
  55. Kroetz D, Deepe G. CCR5 deficiency mitigates the deleterious effects of tumor necrosis factor ? antagonism in murine histoplasmosis. J Infect Dis. 2012;205:955-63 pubmed publisher
    ..Because CCR5 mediates Treg homing and proliferation, we determined the outcome of antagonizing TNF-? in CCR5(-/)(-) mice ..
  56. Song J, Park M, Choi D, Yoo H, Han S, Yoon D, et al. Deficiency of C-C chemokine receptor 5 suppresses tumor development via inactivation of NF-?B and upregulation of IL-1Ra in melanoma model. PLoS ONE. 2012;7:e33747 pubmed publisher
    To evaluate the relevance of C-C chemokine receptor type 5 (CCR5) expression and tumor development, we compared melanoma growth in CCR5 knockout (CCR5(-/-)) mice and wild type (CCR5(+/+)) mice...