Gene Symbol: Ccr1
Description: chemokine (C-C motif) receptor 1
Alias: Cmkbr1, Mip-1a-R, C-C chemokine receptor type 1, C-C CKR-1, CC-CKR-1, CCR-1, MIP-1 alpha R, MIP-1 alphaR, MIP-1alpha-R, RANTES-R, chemokine (C-C) receptor 1, macrophage inflammatory protein 1-alpha receptor
Species: mouse
Products:     Ccr1

Top Publications

  1. Gao J, Wynn T, Chang Y, Lee E, Broxmeyer H, Cooper S, et al. Impaired host defense, hematopoiesis, granulomatous inflammation and type 1-type 2 cytokine balance in mice lacking CC chemokine receptor 1. J Exp Med. 1997;185:1959-68 pubmed
    CC chemokine receptor 1 (CCR1) is expressed in neutrophils, monocytes, lymphocytes, and eosinophils, and binds the leukocyte chemoattractant and hematopoiesis regulator macrophage inflammatory protein (MIP)-1alpha, as well as several ..
  2. He S, Cao Q, Yoneyama H, Ge H, Zhang Y, Zhang Y. MIP-3alpha and MIP-1alpha rapidly mobilize dendritic cell precursors into the peripheral blood. J Leukoc Biol. 2008;84:1549-56 pubmed publisher
    ..MIP-1alpha mobilized a population of F4/80(-)B220(-)CD11c+ DC precursors into peripheral blood by the expression of CCR1 and CCR5...
  3. Khan I, Murphy P, Casciotti L, Schwartzman J, Collins J, Gao J, et al. Mice lacking the chemokine receptor CCR1 show increased susceptibility to Toxoplasma gondii infection. J Immunol. 2001;166:1930-7 pubmed
    ..Mice lacking the chemokine receptor CCR1 have defects in neutrophil trafficking and proliferation...
  4. Gerard C, Frossard J, Bhatia M, Saluja A, Gerard N, Lu B, et al. Targeted disruption of the beta-chemokine receptor CCR1 protects against pancreatitis-associated lung injury. J Clin Invest. 1997;100:2022-7 pubmed
    ..In this report we show that the deletion of another receptor for MIP1alpha and RANTES, the CCR1 receptor, is associated with protection from pulmonary inflammation secondary to acute pancreatitis in the mouse...
  5. Ishida Y, Kimura A, Kondo T, Hayashi T, Ueno M, Takakura N, et al. Essential roles of the CC chemokine ligand 3-CC chemokine receptor 5 axis in bleomycin-induced pulmonary fibrosis through regulation of macrophage and fibrocyte infiltration. Am J Pathol. 2007;170:843-54 pubmed
    ..Compared with WT mice, collagen accumulation was reduced in CCL3(-/-) and CCR5(-/-) but not CCR1(-/-) mice...
  6. Kitamura T, Kometani K, Hashida H, Matsunaga A, Miyoshi H, Hosogi H, et al. SMAD4-deficient intestinal tumors recruit CCR1+ myeloid cells that promote invasion. Nat Genet. 2007;39:467-75 pubmed
    ..These CD34(+) iMCs express the matrix metalloproteinases MMP9 and MMP2 and the CC-chemokine receptor 1 (CCR1) and migrate toward the CCR1 ligand CCL9...
  7. Topham P, Csizmadia V, Soler D, Hines D, Gerard C, Salant D, et al. Lack of chemokine receptor CCR1 enhances Th1 responses and glomerular injury during nephrotoxic nephritis. J Clin Invest. 1999;104:1549-57 pubmed
    ..nephrotoxic nephritis (NTN) in the mouse, we find that a variety of chemokines and chemokine receptors are induced: CCR1 (RANTES, MIP-1alpha), CCR2 (MCP-1), CCR5 (RANTES, MIP-1alpha, MIP-1beta), CXCR2 (MIP-2), and CXCR3 (IP-10)...
  8. Yang X, Lu P, Fujii C, Nakamoto Y, Gao J, Kaneko S, et al. Essential contribution of a chemokine, CCL3, and its receptor, CCR1, to hepatocellular carcinoma progression. Int J Cancer. 2006;118:1869-76 pubmed
    We previously observed that a chemokine, macrophage inflammatory protein-1 alpha/CCL3, and its receptor, CCR1, were aberrantly expressed in human hepatocellular carcinoma (HCC) tissues...
  9. Miller A, Gerard C, Schaller M, Gruber A, Humbles A, Lukacs N. Deletion of CCR1 attenuates pathophysiologic responses during respiratory syncytial virus infection. J Immunol. 2006;176:2562-7 pubmed
    ..In the present studies, we have examined the role of CCR1 in the developing pathogenesis of respiratory syncytial virus (RSV) in the lungs of infected BALB/c mice...

More Information


  1. Domachowske J, Bonville C, Gao J, Murphy P, Easton A, Rosenberg H. The chemokine macrophage-inflammatory protein-1 alpha and its receptor CCR1 control pulmonary inflammation and antiviral host defense in paramyxovirus infection. J Immunol. 2000;165:2677-82 pubmed
    ..the role of MIP-1 alpha in the pathogenesis of this disease using mice deficient in MIP-1 alpha or its receptor, CCR1. The inflammatory response to PVM in MIP-1 alpha-deficient mice was minimal, with approximately 10-60 neutrophils/..
  2. Ness T, Carpenter K, Ewing J, Gerard C, Hogaboam C, Kunkel S. CCR1 and CC chemokine ligand 5 interactions exacerbate innate immune responses during sepsis. J Immunol. 2004;173:6938-48 pubmed
    b>CCR1 has previously been shown to play important roles in leukocyte trafficking, pathogen clearance, and the type 1/type 2 cytokine balance, although very little is known about its role in the host response during sepsis...
  3. Kitamura T, Fujishita T, Loetscher P, Revesz L, Hashida H, Kizaka Kondoh S, et al. Inactivation of chemokine (C-C motif) receptor 1 (CCR1) suppresses colon cancer liver metastasis by blocking accumulation of immature myeloid cells in a mouse model. Proc Natl Acad Sci U S A. 2010;107:13063-8 pubmed publisher
    ..They express CCL9/15 receptor CCR1 and produce matrix metalloproteinases MMP2 and MMP9...
  4. Broxmeyer H, Cooper S, Hangoc G, Gao J, Murphy P. Dominant myelopoietic effector functions mediated by chemokine receptor CCR1. J Exp Med. 1999;189:1987-92 pubmed
    ..MIP-1alpha binds at least three chemokine receptors. To determine if CCR1 was dominantly mediating the above activities of MIP-1alpha, CCR1-deficient (-/-) mice, produced by targeted gene ..
  5. Zhang S, Youn B, Gao J, Murphy P, Kwon B. Differential effects of leukotactin-1 and macrophage inflammatory protein-1 alpha on neutrophils mediated by CCR1. J Immunol. 1999;162:4938-42 pubmed
    ..Lkn-1) is both a strong chemoattractant for neutrophils, monocytes, and lymphocytes and a potent agonist for CCR1 and CCR3...
  6. Gao J, Murphy P. Cloning and differential tissue-specific expression of three mouse beta chemokine receptor-like genes, including the gene for a functional macrophage inflammatory protein-1 alpha receptor. J Biol Chem. 1995;270:17494-501 pubmed
    ..These data identify potentially important new targets for beta chemokine action in the mouse. ..
  7. Hickey M, Held K, Baum E, Gao J, Murphy P, Lane T. CCR1 deficiency increases susceptibility to fatal coronavirus infection of the central nervous system. Viral Immunol. 2007;20:599-608 pubmed
    The role of CC chemokine receptor 1 (CCR1) in host defense and disease development was determined in a model of viral-induced neurologic disease...
  8. Ninichuk V, Gross O, Reichel C, Khandoga A, Pawar R, Ciubar R, et al. Delayed chemokine receptor 1 blockade prolongs survival in collagen 4A3-deficient mice with Alport disease. J Am Soc Nephrol. 2005;16:977-85 pubmed
    ..This question was addressed by treating COL4A3-deficient mice with BX471, an antagonist of chemokine receptor 1 (CCR1) that is known to block interstitial leukocyte recruitment...
  9. Eis V, Luckow B, Vielhauer V, Siveke J, Linde Y, Segerer S, et al. Chemokine receptor CCR1 but not CCR5 mediates leukocyte recruitment and subsequent renal fibrosis after unilateral ureteral obstruction. J Am Soc Nephrol. 2004;15:337-47 pubmed
    As chemokine receptor CCR1 and CCR5 expression on circulating leukocytes is thought to contribute to leukocyte recruitment during renal fibrosis, the authors examined the effects of unilateral ureteral obstruction (UUO) in mice deficient ..
  10. Post T, Bozic C, Rothenberg M, Luster A, Gerard N, Gerard C. Molecular characterization of two murine eosinophil beta chemokine receptors. J Immunol. 1995;155:5299-305 pubmed
    ..Murine MIP-1 alpha was found to be a potent chemoattractant for murine eosinophils. Our findings suggest that the murine MIP-1 alpha ligand/receptor system is an important mediator of murine eosinophil trafficking. ..
  11. Furuichi K, Gao J, Horuk R, Wada T, Kaneko S, Murphy P. Chemokine receptor CCR1 regulates inflammatory cell infiltration after renal ischemia-reperfusion injury. J Immunol. 2008;181:8670-6 pubmed
    ..Here we provide genetic and pharmacologic evidence supporting a positive role for the chemokine receptor CCR1 in macrophage and neutrophil infiltration in a 7 day mouse model of renal ischemia-reperfusion injury...
  12. Chou R, Kim N, Sadik C, Seung E, Lan Y, Byrne M, et al. Lipid-cytokine-chemokine cascade drives neutrophil recruitment in a murine model of inflammatory arthritis. Immunity. 2010;33:266-78 pubmed publisher
    ..b>CCR1 and CXCR2, two neutrophil chemokine receptors, operate nonredundantly to sequentially control the later phase of ..
  13. Rottman J, Slavin A, Silva R, Weiner H, Gerard C, Hancock W. Leukocyte recruitment during onset of experimental allergic encephalomyelitis is CCR1 dependent. Eur J Immunol. 2000;30:2372-7 pubmed
    ..within demyelinating plaques of patients with multiple sclerosis (MS) are immunoreactive for the chemokine receptor CCR1 and its ligand, macrophage inflammatory protein-1alpha...
  14. Nansen A, Marker O, Bartholdy C, Thomsen A. CCR2+ and CCR5+ CD8+ T cells increase during viral infection and migrate to sites of infection. Eur J Immunol. 2000;30:1797-806 pubmed
    ..Cerebral CCR gene expression was dominated by CCR1, CCR2 and CCR5...
  15. Quinones M, Kalkonde Y, Estrada C, Jimenez F, Ramirez R, Mahimainathan L, et al. Role of astrocytes and chemokine systems in acute TNFalpha induced demyelinating syndrome: CCR2-dependent signals promote astrocyte activation and survival via NF-kappaB and Akt. Mol Cell Neurosci. 2008;37:96-109 pubmed
    ..Notably, the CCL2 (MCP-1)-CCR2 axis and the closely related ligand-receptor pair CCR1-CCL3 (MIP-1alpha) were among the most up-regulated during disease...
  16. Blease K, Mehrad B, Standiford T, Lukacs N, Kunkel S, Chensue S, et al. Airway remodeling is absent in CCR1-/- mice during chronic fungal allergic airway disease. J Immunol. 2000;165:1564-72 pubmed
    ..fumigatus spores or conidia, the present study addressed the role of their receptor, C-C chemokine receptor 1 (CCR1), in this model. A...
  17. Ninichuk V, Anders H. Chemokine receptor CCR1: a new target for progressive kidney disease. Am J Nephrol. 2005;25:365-72 pubmed
    ..By using mutant mice and specific antagonists, we found that chemokine receptor CCR1 has non-redundant functions for leukocyte adhesion to activated vascular endothelium and for transendothelial ..
  18. Price P, Luckow B, Torres Domínguez L, Brandmüller C, Zorn J, Kirschning C, et al. Chemokine (C-C Motif) receptor 1 is required for efficient recruitment of neutrophils during respiratory infection with modified vaccinia virus Ankara. J Virol. 2014;88:10840-50 pubmed publisher
    ..Additionally, we show that both chemokine (C-C motif) receptor 1 (CCR1) and chemokine (C-X-C motif) receptor 2 (CXCR2) are involved in MVA-induced neutrophil chemotaxis in vitro...
  19. Kiguchi N, Kobayashi Y, Maeda T, Saika F, Kishioka S. CC-chemokine MIP-1? in the spinal cord contributes to nerve injury-induced neuropathic pain. Neurosci Lett. 2010;484:17-21 pubmed publisher
    ..PSL increased MIP-1? mRNA levels as well as levels of the MIP-1? receptor, CCR1, but not CCR5 in the spinal dorsal horn...
  20. Anders H, Belemezova E, Eis V, Segerer S, Vielhauer V, Perez de Lema G, et al. Late onset of treatment with a chemokine receptor CCR1 antagonist prevents progression of lupus nephritis in MRL-Fas(lpr) mice. J Am Soc Nephrol. 2004;15:1504-13 pubmed
    ..immune complex glomerulonephritis in autoimmune MRL(lpr/lpr) mice was used to evaluate whether chemokine receptor CCR1 blockade late in the disease course can affect progression to renal failure...
  21. Choi S, Hildebrandt G, Olkiewicz K, Hanauer D, Chaudhary M, Silva I, et al. CCR1/CCL5 (RANTES) receptor-ligand interactions modulate allogeneic T-cell responses and graft-versus-host disease following stem-cell transplantation. Blood. 2007;110:3447-55 pubmed
    ..We examined the contribution of donor cell CCR1 expression to the development of GVHD and GVL using a well-established murine SCT model (B6 --> B6D2F1) and CCR1-..
  22. Kang S, Liang H, Reizis B, Locksley R. Regulation of hierarchical clustering and activation of innate immune cells by dendritic cells. Immunity. 2008;29:819-33 pubmed publisher
    ..Thus, spatial organization of the immune response by DCs between 6 and 24 hr ensures functional activation of innate cells, which restricts pathogens before adaptive immunity is fully activated. ..
  23. Di Marzio P, Dai W, Franchin G, Chan A, Symons M, Sherry B. Role of Rho family GTPases in CCR1- and CCR5-induced actin reorganization in macrophages. Biochem Biophys Res Commun. 2005;331:909-16 pubmed
    ..Herein, we demonstrate that the binding of each of these beta-chemokines to their cognate receptors, CCR1 and CCR5, in either macrophages or in CCR1- or CCR5-transfected CHO cells, induced actin reorganization and the ..
  24. Bonville C, Lau V, DeLeon J, Gao J, Easton A, Rosenberg H, et al. Functional antagonism of chemokine receptor CCR1 reduces mortality in acute pneumovirus infection in vivo. J Virol. 2004;78:7984-9 pubmed
    ..We show here that ribavirin reduces mortality, from 100% to 10 and 30%, respectively, in gene-deleted CCR1(-/-) mice and in wild-type mice treated with the small-molecule chemokine receptor antagonist, Met-RANTES...
  25. Hamrah P, Yamagami S, Liu Y, Zhang Q, Vora S, Lu B, et al. Deletion of the chemokine receptor CCR1 prolongs corneal allograft survival. Invest Ophthalmol Vis Sci. 2007;48:1228-36 pubmed
    ..Initial experiments revealed gene upregulation of the chemokine receptors CCR1, -2, and -5 after corneal allorejection...
  26. Oba Y, Lee J, Ehrlich L, Chung H, Jelinek D, Callander N, et al. MIP-1alpha utilizes both CCR1 and CCR5 to induce osteoclast formation and increase adhesion of myeloma cells to marrow stromal cells. Exp Hematol. 2005;33:272-8 pubmed
    ..Several chemokine receptors (CCR1, CCR5, and CCR9) mediate the effects of MIP-1alpha...
  27. Potteaux S, Combadiere C, Esposito B, Casanova S, Merval R, Ardouin P, et al. Chemokine receptor CCR1 disruption in bone marrow cells enhances atherosclerotic lesion development and inflammation in mice. Mol Med. 2005;11:16-20 pubmed
    Several chemokines or chemokine receptors are involved in atherogenesis. CCR1 is expressed by macrophages and lymphocytes, two major cell types involved in the progression of atherosclerosis, and binds to lesion-expressed ligands...
  28. Sawanobori Y, Ueha S, Kurachi M, Shimaoka T, Talmadge J, Abe J, et al. Chemokine-mediated rapid turnover of myeloid-derived suppressor cells in tumor-bearing mice. Blood. 2008;111:5457-66 pubmed publisher
    ..Overall, our data established the identity and dynamics of MDSCs in a tumor-bearing host mediated by chemokines and elucidated unexpected effects of the paucity of macrophages on tumor development. ..
  29. Zhang H, Meng F, Chu C, Takai T, Lowell C. The Src family kinases Hck and Fgr negatively regulate neutrophil and dendritic cell chemokine signaling via PIR-B. Immunity. 2005;22:235-46 pubmed
    ..These data support a model in which the Src family kinases Hck and Fgr function as negative regulators of myeloid cell chemokine signaling by maintaining the tonic phosphorylation of PIR-B. ..
  30. Seki E, De Minicis S, Gwak G, Kluwe J, Inokuchi S, Bursill C, et al. CCR1 and CCR5 promote hepatic fibrosis in mice. J Clin Invest. 2009;119:1858-70 pubmed
    ..The CC chemokines MIP-1alpha, MIP-1beta, and RANTES and their receptors CCR1 and CCR5 were strongly upregulated in 2 experimental mouse models of fibrogenesis...
  31. Lewis N, Muthukumarana A, Fogal S, Corradini L, Stefanopoulos D, Adusumalli P, et al. CCR1 plays a critical role in modulating pain through hematopoietic and non-hematopoietic cells. PLoS ONE. 2014;9:e105883 pubmed publisher
    ..CC chemokine receptor 1 (CCR1) mediates trafficking of leukocytes to sites of inflammation...
  32. Iida N, Nakamoto Y, Baba T, Kakinoki K, Li Y, Wu Y, et al. Tumor cell apoptosis induces tumor-specific immunity in a CC chemokine receptor 1- and 5-dependent manner in mice. J Leukoc Biol. 2008;84:1001-10 pubmed publisher
    ..Tumor-infiltrating DCs expressed chemokine receptors CCR1 and CCR5, and T cells and macrophages expressed CCL3, a ligand for CCR1 and CCR5...
  33. Zhao X, Sato A, Dela Cruz C, Linehan M, Luegering A, Kucharzik T, et al. CCL9 is secreted by the follicle-associated epithelium and recruits dome region Peyer's patch CD11b+ dendritic cells. J Immunol. 2003;171:2797-803 pubmed
    ..By RT-PCR, we demonstrated that one of the putative receptors for CCL9, CCR1, was expressed by the Peyer's patch CD11b(+) DCs and in a chemotaxis assay, CD11b(+) DCs migrated toward CCL9...
  34. Gao W, Topham P, King J, Smiley S, Csizmadia V, Lu B, et al. Targeting of the chemokine receptor CCR1 suppresses development of acute and chronic cardiac allograft rejection. J Clin Invest. 2000;105:35-44 pubmed
    ..Inbred mice with a targeted deletion of the chemokine receptor CCR1 showed significant prolongation of allograft survival in 4 models...
  35. Hoshino A, Iimura T, Ueha S, Hanada S, Maruoka Y, Mayahara M, et al. Deficiency of chemokine receptor CCR1 causes osteopenia due to impaired functions of osteoclasts and osteoblasts. J Biol Chem. 2010;285:28826-37 pubmed publisher
    ..The chemokine receptor, CCR1, and its ligands are thought to be involved in inflammatory bone destruction, but their physiological roles in the ..
  36. Baba T, Tanabe Y, Yoshikawa S, Yamanishi Y, Morishita S, Komatsu N, et al. MIP-1α/CCL3-expressing basophil-lineage cells drive the leukemic hematopoiesis of chronic myeloid leukemia in mice. Blood. 2016;127:2607-17 pubmed publisher
  37. Kaesler S, Bugnon P, Gao J, Murphy P, Goppelt A, Werner S. The chemokine receptor CCR1 is strongly up-regulated after skin injury but dispensable for wound healing. Wound Repair Regen. 2004;12:193-204 pubmed
    ..One of the identified genes encodes the chemokine receptor CCR1, which binds several chemokines present at the wound site...
  38. Reichel C, Puhr Westerheide D, Zuchtriegel G, Uhl B, Berberich N, Zahler S, et al. C-C motif chemokine CCL3 and canonical neutrophil attractants promote neutrophil extravasation through common and distinct mechanisms. Blood. 2012;120:880-90 pubmed publisher
    ..synonym MIP-1?) were significantly diminished in mice with a deficiency of the chemokine (C-C motif) receptor 1 (Ccr1(-/-)) or 5 (Ccr5(-/-))...
  39. Huang J, Zhang Z, Guo J, Ni A, Deb A, Zhang L, et al. Genetic modification of mesenchymal stem cells overexpressing CCR1 increases cell viability, migration, engraftment, and capillary density in the injured myocardium. Circ Res. 2010;106:1753-62 pubmed publisher
    ..However the expression levels of the corresponding chemokine receptors (eg, CCR1, CXCR2) in MSCs are very low...
  40. Baba T, Nakamoto Y, Mukaida N. Crucial contribution of thymic Sirp alpha+ conventional dendritic cells to central tolerance against blood-borne antigens in a CCR2-dependent manner. J Immunol. 2009;183:3053-63 pubmed publisher
    ..Given their intrathymic cortical localization, CD11c(+)B220(-)CD8alpha(-)Sirpalpha(+) cDCs can have a unique role in the development of central tolerance against circulating peripheral Ags, at least partially in a CCR2-dependent manner. ..
  41. Xu J, Long L, Tang Y, Zhang J, Hut H, Tang F. CCR3, CCR2A and macrophage inflammatory protein (MIP)-1a, monocyte chemotactic protein-1 (MCP-1) in the mouse hippocampus during and after pilocarpine-induced status epilepticus (PISE) . Neuropathol Appl Neurobiol. 2009;35:496-514 pubmed publisher
    ..However, induced expression of MCP-1 in hippocampal blood vessel may be related to changes in permeability of the blood-brain barrier during epileptogenesis. ..
  42. Gilliland C, SALANGA C, Kawamura T, Trejo J, Handel T. The chemokine receptor CCR1 is constitutively active, which leads to G protein-independent, ?-arrestin-mediated internalization. J Biol Chem. 2013;288:32194-210 pubmed publisher
    ..In this report, we show that the CC-type chemokine receptor 1 (CCR1) exhibits significant constitutive activity leading to a variety of cellular responses...
  43. Taddei S, Queiroz Junior C, Moura A, Andrade I, Garlet G, Proudfoot A, et al. The effect of CCL3 and CCR1 in bone remodeling induced by mechanical loading during orthodontic tooth movement in mice. Bone. 2013;52:259-67 pubmed publisher
    ..chemokine (C-C motif) ligand 3 (CCL3) is involved in bone remodeling by binding to C-C chemokine receptors 1 and 5 (CCR1 and CCR5) expressed on osteoclasts and osteoblasts...
  44. Fifadara N, Beer F, Ono S, Ono S. Interaction between activated chemokine receptor 1 and FcepsilonRI at membrane rafts promotes communication and F-actin-rich cytoneme extensions between mast cells. Int Immunol. 2010;22:113-28 pubmed publisher
    ..Whereas FcepsilonRI and CCR1 co-localized at the plasma membrane in unsensitized cells, sensitization with IgE promoted internalization of CCR1 ..
  45. Zernecke A, Liehn E, Gao J, Kuziel W, Murphy P, Weber C. Deficiency in CCR5 but not CCR1 protects against neointima formation in atherosclerosis-prone mice: involvement of IL-10. Blood. 2006;107:4240-3 pubmed
    ..We analyzed the differential role of the RANTES receptors CCR1 and CCR5 by genetic deletion in apolipoprotein E-deficient mice...
  46. Reichel C, Khandoga A, Anders H, Schlondorff D, Luckow B, Krombach F. Chemokine receptors Ccr1, Ccr2, and Ccr5 mediate neutrophil migration to postischemic tissue. J Leukoc Biol. 2006;79:114-22 pubmed
    ..However, the role of chemokine receptors Ccr1, Ccr2, and Ccr5 for each single step of the postischemic recruitment process of leukocytes has not yet been ..
  47. Ramos C, Canetti C, Souto J, Silva J, Hogaboam C, Ferreira S, et al. MIP-1alpha[CCL3] acting on the CCR1 receptor mediates neutrophil migration in immune inflammation via sequential release of TNF-alpha and LTB4. J Leukoc Biol. 2005;78:167-77 pubmed
    ..Herein, we show increased mRNA expression for MIP-1alpha[CCL3], MIP-1beta[CCL4], RANTES[CCL5], and CCR1 in peritoneal cells harvested from OVA-challenged, immunized mice, as well as MIP-1alpha[CCL3] and RANTES[CCL5] but ..
  48. Ramos M, Auvynet C, Poupel L, Rodero M, Mejías M, Panek C, et al. Chemokine receptor CCR1 disruption limits renal damage in a murine model of hemolytic uremic syndrome. Am J Pathol. 2012;180:1040-8 pubmed publisher
    ..Because the chemokine receptor CCR1 participates in the pathogenesis of several renal diseases by orchestrating myeloid cell kidney infiltration, we ..
  49. Iida N, Nakamoto Y, Baba T, Nakagawa H, Mizukoshi E, Naito M, et al. Antitumor effect after radiofrequency ablation of murine hepatoma is augmented by an active variant of CC Chemokine ligand 3/macrophage inflammatory protein-1alpha. Cancer Res. 2010;70:6556-65 pubmed publisher
    ..antitumor effect against non-RFA-treated tumors when administered to wild-type or CCR5-deficient but not CCR1-deficient mice...
  50. Onnervik P, Lindahl M, Svitacheva N, Stampfli M, Thim K, Smailagic A, et al. The role of the CCR1 receptor in the inflammatory response to tobacco smoke in a mouse model. Inflamm Res. 2010;59:817-25 pubmed publisher
    ..Challenge of chemokine receptor type 1 (CCR1) KO mice in the tobacco smoke model showed that lack of this gene protected the mice from smoke-induced ..
  51. Lieberam I, Agalliu D, Nagasawa T, Ericson J, Jessell T. A Cxcl12-CXCR4 chemokine signaling pathway defines the initial trajectory of mammalian motor axons. Neuron. 2005;47:667-79 pubmed
    ..In its absence, these neurons adopt a dMN-like trajectory, despite preservation of their vMN transcriptional identity. Thus, the status of Cxcr4 signaling helps to determine the initial axonal trajectory of mammalian motor neurons. ..
  52. Wu Y, Li Y, Matsushima K, Baba T, Mukaida N. CCL3-CCR5 axis regulates intratumoral accumulation of leukocytes and fibroblasts and promotes angiogenesis in murine lung metastasis process. J Immunol. 2008;181:6384-93 pubmed
    ..Collectively, the CCL3-CCR5 axis appears to regulate intratumoral trafficking of leukocytes and fibroblasts, as well as MMP-9 and HGF expression, and as a consequence to accelerate neovascularization and subsequent metastasis formation. ..
  53. Camargo J, Quinones M, Mummidi S, Srinivas S, Gaitan A, Begum K, et al. CCR5 expression levels influence NFAT translocation, IL-2 production, and subsequent signaling events during T lymphocyte activation. J Immunol. 2009;182:171-82 pubmed
    ..In accord with our prior inferences from genetic-epidemiologic studies, such CCR5-dependent responses might constitute a viral entry-independent mechanism by which CCR5 may influence HIV-AIDS pathogenesis. ..
  54. Baba T, Naka K, Morishita S, Komatsu N, Hirao A, Mukaida N. MIP-1?/CCL3-mediated maintenance of leukemia-initiating cells in the initiation process of chronic myeloid leukemia. J Exp Med. 2013;210:2661-73 pubmed publisher
    ..Finally, normal hematopoietic stem/progenitor cells can directly impede the maintenance of LICs in BM in the absence of CCL3 signal. ..
  55. Lu P, Li L, Wu Y, Mukaida N, Zhang X. Essential contribution of CCL3 to alkali-induced corneal neovascularization by regulating vascular endothelial growth factor production by macrophages. Mol Vis. 2008;14:1614-22 pubmed
    To evaluate the roles of CCL3 and its specific chemokine receptors, CCR1 and CCR5, in alkali-induced corneal neovascularization (CNV).
  56. Yu X, Huang Y, Collin Osdoby P, Osdoby P. CCR1 chemokines promote the chemotactic recruitment, RANKL development, and motility of osteoclasts and are induced by inflammatory cytokines in osteoblasts. J Bone Miner Res. 2004;19:2065-77 pubmed
    ..A chemokine receptor, CCR1, was expressed in OC precursors and elevated in mature OCs, and its ligands promoted OC precursor recruitment, ..
  57. Salem M, Al Khami A, El Naggar S, Diaz Montero C, Chen Y, Cole D. Cyclophosphamide induces dynamic alterations in the host microenvironments resulting in a Flt3 ligand-dependent expansion of dendritic cells. J Immunol. 2010;184:1737-47 pubmed publisher
    ..Targeting DCs at these phases would significantly improve their contribution to the clinical application of lymphodepletion to adoptive immunotherapy. ..
  58. Bignon A, Gaudin F, Hemon P, Tharinger H, Mayol K, Walzer T, et al. CCR1 inhibition ameliorates the progression of lupus nephritis in NZB/W mice. J Immunol. 2014;192:886-96 pubmed publisher
    ..In this study, we investigated the role of the Ccr1 chemokine receptor in this infiltration process during the progression of nephritis in the lupus-prone New Zealand ..
  59. John A, Gerard C, Schaller M, Miller A, Berlin A, Humbles A, et al. Respiratory syncytial virus-induced exaggeration of allergic airway disease is dependent upon CCR1-associated immune responses. Eur J Immunol. 2005;35:108-16 pubmed
    ..b>CCR1 mRNA was significantly up-regulated during primary RSV infection in BALB/c mice, and was also up-regulated during ..
  60. Hall L, Diaconu E, Patel R, Pearlman E. CXC chemokine receptor 2 but not C-C chemokine receptor 1 expression is essential for neutrophil recruitment to the cornea in helminth-mediated keratitis (river blindness). J Immunol. 2001;166:4035-41 pubmed
    ..determined the relative contribution of chemokine receptors CXC chemokine receptor (CXCR)-2 (IL-8R homologue) and CCR1 using a murine model of ocular onchocerciasis (river blindness) in which neutrophils and eosinophils migrate from ..
  61. Kiss H, Darai E, Kiss C, Kost Alimova M, Klein G, Dumanski J, et al. Comparative human/murine sequence analysis of the common eliminated region 1 from human 3p21.3. Mamm Genome. 2002;13:646-55 pubmed
    ..We observed that two orthologous mouse genes (Xtrp3s1 and Cmkbr1) were duplicated, and this resulted in two additional expressed mouse genes (Xtrp3 and Cmkbr111)...
  62. Demoule A, Divangahi M, Yahiaoui L, Danialou G, Gvozdic D, Petrof B. Chemokine receptor and ligand upregulation in the diaphragm during endotoxemia and Pseudomonas lung infection. Mediators Inflamm. 2009;2009:860565 pubmed publisher
    ..Constitutive expression levels of RANTES and MIP-1alpha, as well as their receptors, CCR1 and CCR5, were significantly higher in diaphragm than limb muscle...
  63. Sun J, Ramnath R, Bhatia M. Neuropeptide substance P upregulates chemokine and chemokine receptor expression in primary mouse neutrophils. Am J Physiol Cell Physiol. 2007;293:C696-704 pubmed
    ..Together, these results suggest that SP exerts a direct stimulatory effect on the expression of chemokines and chemokine receptors in mouse neutrophils. The effect is NK-1R mediated, involving NF-kappaB activation. ..
  64. Morteau O, Castagliuolo I, Mykoniatis A, Zacks J, Wlk M, Lu B, et al. Genetic deficiency in the chemokine receptor CCR1 protects against acute Clostridium difficile toxin A enteritis in mice. Gastroenterology. 2002;122:725-33 pubmed
    The role of the CC chemokine receptor (CCR) 1 in acute enteritis was investigated by subjecting CCR1 knockout mice to Clostridium difficile toxin A treatment...
  65. Chiu B, Freeman C, Stolberg V, Hu J, Zeibecoglou K, Lu B, et al. Impaired lung dendritic cell activation in CCR2 knockout mice. Am J Pathol. 2004;165:1199-209 pubmed
    ..To determine the role of chemokines in DC mobilization, we applied this analysis to CCR1, CCR2, CCR5, and CCR6 chemokine receptor knockout mice...
  66. Yamagami S, Hamrah P, Miyamoto K, Miyazaki D, Dekaris I, Dawson T, et al. CCR5 chemokine receptor mediates recruitment of MHC class II-positive Langerhans cells in the mouse corneal epithelium. Invest Ophthalmol Vis Sci. 2005;46:1201-7 pubmed
    ..b>CCR1, -2, and -5 were overexpressed in corneas after cauterization...
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    ..In this work, we studied the role of CCR1 and CCR5, two known chemokine receptors, in both chemotaxis and osteolysis in the experimental 5TMM mouse model...
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    ..Based on the previous description of the involvement of CC chemokine receptor type 1 (CCR1) in pathological pain, we have assessed the participation of CCR1 and its endogenous ligands CCL3 and CCL5 in ..
  70. Nosaka T, Baba T, Tanabe Y, Sasaki S, Nishimura T, Imamura Y, et al. Alveolar Macrophages Drive Hepatocellular Carcinoma Lung Metastasis by Generating Leukotriene B4. J Immunol. 2018;200:1839-1852 pubmed publisher
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    ..Microglia/macrophages are found within human GBM where they likely promote tumor progression. We report that CCL5, CCR1, and CCR5 are expressed in glioblastoma...
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    CC chemokine receptor 1 (CCR1) is found on a variety of cells in the immune system and has been shown to play an important role in the host response to pathogens...
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    ..Using the MembStruk computational method (3), we predicted the three-dimensional structure of the human CCR1 receptor...
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    ..In this study, we sought to determine whether blockade of chemokine receptors CCR1 and CCR5 with Met-RANTES affects the development of CAV in a murine model. B6...
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    ..In accord with these findings, a targeted null mutation of CCR1, a putative C10/CCL6 receptor, also decreased IL-13-induced inflammation and alveolar remodeling and caused ..
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    ..5 and E8.5). Other chemokine receptor messages (CCR1, CCR4, CCR5, CCR2, and CXCR2) were found in E12...
  77. Hoogewerf A, Black D, Proudfoot A, Wells T, Power C. Molecular cloning of murine CC CKR-4 and high affinity binding of chemokines to murine and human CC CKR-4. Biochem Biophys Res Commun. 1996;218:337-43 pubmed
    ..This first report of direct binding of chemokines to CC CKR-4 demonstrates that the highly homologous human and murine receptors have similar binding characteristics and tissue distribution. ..
  78. Domachowske J, Bonville C, Gao J, Murphy P, Easton A, Rosenberg H. MIP-1alpha is produced but it does not control pulmonary inflammation in response to respiratory syncytial virus infection in mice. Cell Immunol. 2000;206:1-6 pubmed
    ..leukocytes/ml BAL fluid) that was dependent on both local production of MIP-1alpha and signaling via its receptor, CCR1. We find here that MIP-1alpha is also produced in response to RSV, although relatively few leukocytes (<200 ml ..