Gene Symbol: Ccnf
Description: cyclin F
Alias: CycF, Fbxo1, cyclin-F, G2/mitotic-specific cyclin-F
Tetzlaff M, Bai C, Finegold M, Wilson J, Harper J, Mahon K, et al
. Cyclin F disruption compromises placental development and affects normal cell cycle execution. Mol Cell Biol. 2004;24:2487-98 pubmed
Human cyclin F was originally isolated as a cDNA capable of suppressing the temperature sensitivity of a Saccharomyces cerevisiae cdc4-1 mutant...
Mangale S, Modi D, Reddy K. Identification of genes regulated by an interaction between alphavbeta3 integrin and vitronectin in murine decidua. Reprod Fertil Dev. 2008;20:311-9 pubmed
..Signalling through alpha(v)beta(3) seems to be important to maintain a balance between cell proliferation and apoptosis, along with the modulation of inflammatory responses of decidual cells. ..
Manceau V, Kremmer E, Nabel E, Maucuer A. The protein kinase KIS impacts gene expression during development and fear conditioning in adult mice. PLoS ONE. 2012;7:e43946 pubmed publisher
..This difference suggests that disregulation of gene expression due to KIS inactivation affects specific brain functions. ..
Obermayr F, Sutherland H, Kraus B, Frischauf A. Mouse cyclin F maps to a conserved linkage group on mouse chromosome 17. Mamm Genome. 1995;6:149-50 pubmed
Kong M, Barnes E, Ollendorff V, Donoghue D. Cyclin F regulates the nuclear localization of cyclin B1 through a cyclin-cyclin interaction. EMBO J. 2000;19:1378-88 pubmed
..potentially mediating localization of cyclin B1 and identified a novel interaction between cyclin B1 and cyclin F. We found that cdc2, cyclin B1 and cyclin F form a complex that exhibits histone H1 kinase activity...
Kozar K, Ciemerych M, Rebel V, Shigematsu H, Zagozdzon A, Sicinska E, et al
. Mouse development and cell proliferation in the absence of D-cyclins. Cell. 2004;118:477-91 pubmed
..Lastly, we found that cells lacking D-cyclins display reduced susceptibility to the oncogenic transformation. Our results reveal the presence of alternative mechanisms that allow cell cycle progression in a cyclin D-independent fashion. ..
D Angiolella V, Donato V, Vijayakumar S, Saraf A, Florens L, Washburn M, et al
. SCF(Cyclin F) controls centrosome homeostasis and mitotic fidelity through CP110 degradation. Nature. 2010;466:138-42 pubmed publisher
..The F-box protein family obtained its name from Cyclin F (also called Fbxo1), in which the F-box motif (the approximately 40-amino-acid domain required for binding to ..