Ccnd1

Summary

Gene Symbol: Ccnd1
Description: cyclin D1
Alias: AI327039, CycD1, Cyl-1, PRAD1, bcl-1, cD1, G1/S-specific cyclin-D1
Species: mouse

Top Publications

  1. pmc Inactivation of Chibby affects function of motile airway cilia
    Vera A Voronina
    Department of Pharmacology, Howard Hughes Medical Institute, USA
    J Cell Biol 185:225-33. 2009
  2. pmc Cyclins D2 and D1 are essential for postnatal pancreatic beta-cell growth
    Jake A Kushner
    Division of Endocrinology, Children s Hospital of Philadelphia, 3615 Civic Center Blvd, Philadelphia, PA 19104, USA
    Mol Cell Biol 25:3752-62. 2005
  3. ncbi Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle
    H Matsushime
    Department of Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38105
    Cell 65:701-13. 1991
  4. pmc ErbB2/Neu-induced, cyclin D1-dependent transformation is accelerated in p27-haploinsufficient mammary epithelial cells but impaired in p27-null cells
    Rebecca S Muraoka
    Department of Cancer Biology, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Mol Cell Biol 22:2204-19. 2002
  5. pmc Interactions of Wnt/beta-catenin signaling and sonic hedgehog regulate the neurogenesis of ventral midbrain dopamine neurons
    Mianzhi Tang
    Department of Pathology, University of California, San Francisco and Pathology Service, Veterans Affairs Medical Center, San Francisco, California 94121, USA
    J Neurosci 30:9280-91. 2010
  6. ncbi p21(Cip1) Promotes cyclin D1 nuclear accumulation via direct inhibition of nuclear export
    Jodi R Alt
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
    J Biol Chem 277:8517-23. 2002
  7. pmc Nuclear accumulation of cyclin D1 during S phase inhibits Cul4-dependent Cdt1 proteolysis and triggers p53-dependent DNA rereplication
    Priya Aggarwal
    The Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Genes Dev 21:2908-22. 2007
  8. ncbi Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic mice
    T C Wang
    Department of Medicine, Massachusetts General Hospital, Boston 02114
    Nature 369:669-71. 1994
  9. ncbi Genetic rescue of cell number in a mouse model of microphthalmia: interactions between Chx10 and G1-phase cell cycle regulators
    Eric S Green
    Department of Ophthalmology and Visual Sciences, John A Moran Eye Center, University of Utah, Salt Lake City, UT 84132, USA
    Development 130:539-52. 2003
  10. ncbi Cyclin D1 provides a link between development and oncogenesis in the retina and breast
    P Sicinski
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, USA
    Cell 82:621-30. 1995

Research Grants

  1. ASBESTOS AND NO2 IN ENVIRONMENTAL LUNG DISEASE
    Nicholas Heintz; Fiscal Year: 2001
  2. C/EBPB And Mitotic Clonal Expansion During Adipogenesis
    Qi Qun Tang; Fiscal Year: 2004
  3. ROLE OF CYCLINS D2 AND D3 IN LYPHIOD CELL PROLIFERATION
    Piotr Sicinski; Fiscal Year: 2004
  4. HAND GENES IN CARDIAC DEVELOPMENT
    William Pu; Fiscal Year: 2004
  5. Mechanisms of endoderm specification along the A-P axis.
    James M Wells; Fiscal Year: 2010
  6. ROLES OF SOX C GENES IN SKELETOGENESIS
    VERONIQUE M LEFEBVRE; Fiscal Year: 2010
  7. Chemoprevention in Mice after Tobacco Smoke Exposure
    Hanspeter Witschi; Fiscal Year: 2004
  8. Cyclin D1 and mammary carcinoma
    J Diehl; Fiscal Year: 2009
  9. Signaling Pathways in Proliferation and Differentiation
    MARK EWEN; Fiscal Year: 2009
  10. Cell cycle control of vascular remodeling
    RICHARD ASSOIAN; Fiscal Year: 2009

Detail Information

Publications148 found, 100 shown here

  1. pmc Inactivation of Chibby affects function of motile airway cilia
    Vera A Voronina
    Department of Pharmacology, Howard Hughes Medical Institute, USA
    J Cell Biol 185:225-33. 2009
    ..As the phenotypes of Cby(-/-) mice bear striking similarities to primary ciliary dyskinesia, Cby(-/-) mice may prove to be a useful model for this condition...
  2. pmc Cyclins D2 and D1 are essential for postnatal pancreatic beta-cell growth
    Jake A Kushner
    Division of Endocrinology, Children s Hospital of Philadelphia, 3615 Civic Center Blvd, Philadelphia, PA 19104, USA
    Mol Cell Biol 25:3752-62. 2005
    ..Thus, cyclins D2 and D1 were essential for beta-cell expansion in adult mice. Strategies to tightly regulate D-type cyclin activity in beta cells could prevent or cure diabetes...
  3. ncbi Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle
    H Matsushime
    Department of Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38105
    Cell 65:701-13. 1991
    ..The timing of p36CYL expression, its rapid turnover in the absence of CSF-1, and its phosphorylation and transient binding to a cdc2-related polypeptide suggest that CYL genes may function during S phase commitment...
  4. pmc ErbB2/Neu-induced, cyclin D1-dependent transformation is accelerated in p27-haploinsufficient mammary epithelial cells but impaired in p27-null cells
    Rebecca S Muraoka
    Department of Cancer Biology, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Mol Cell Biol 22:2204-19. 2002
    ..These results suggest that p27(+/-) mammary epithelium may be more susceptible to oncogene-induced tumorigenesis, whereas p27-null glands, due to severely impaired cyclin D1/Cdk4 function, are more resistant to transformation...
  5. pmc Interactions of Wnt/beta-catenin signaling and sonic hedgehog regulate the neurogenesis of ventral midbrain dopamine neurons
    Mianzhi Tang
    Department of Pathology, University of California, San Francisco and Pathology Service, Veterans Affairs Medical Center, San Francisco, California 94121, USA
    J Neurosci 30:9280-91. 2010
    ..Persistent activation of beta-catenin in early progenitors perturbs their cell cycle progression and antagonizes Shh expression, whereas activation of beta-catenin in midline progenitors promotes the generation of dopamine neurons...
  6. ncbi p21(Cip1) Promotes cyclin D1 nuclear accumulation via direct inhibition of nuclear export
    Jodi R Alt
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
    J Biol Chem 277:8517-23. 2002
    ..The ability of p21(Cip1) to inhibit cyclin D1 nuclear export correlates with its ability to bind to Thr-286-phosphorylated cyclin D1 and thereby prevents cyclin D1.CRM1 association...
  7. pmc Nuclear accumulation of cyclin D1 during S phase inhibits Cul4-dependent Cdt1 proteolysis and triggers p53-dependent DNA rereplication
    Priya Aggarwal
    The Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Genes Dev 21:2908-22. 2007
    ..Collectively, the data presented reveal mechanistic insights into how uncoupling of critical cell cycle regulatory events will perturb DNA replication fidelity, thereby contributing to neoplastic transformation...
  8. ncbi Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic mice
    T C Wang
    Department of Medicine, Massachusetts General Hospital, Boston 02114
    Nature 369:669-71. 1994
    ..Cyclin D1 was identified as a candidate oncogene (PRAD1) in tumour-specific DNA rearrangements and is suspected to be a contributor to several types of neoplasms ..
  9. ncbi Genetic rescue of cell number in a mouse model of microphthalmia: interactions between Chx10 and G1-phase cell cycle regulators
    Eric S Green
    Department of Ophthalmology and Visual Sciences, John A Moran Eye Center, University of Utah, Salt Lake City, UT 84132, USA
    Development 130:539-52. 2003
    ..This is the first report of rescue of retinal proliferation in a microphthalmia model by deletion of a cell cycle regulatory gene...
  10. ncbi Cyclin D1 provides a link between development and oncogenesis in the retina and breast
    P Sicinski
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, USA
    Cell 82:621-30. 1995
    ..Thus, steroid-induced proliferation of mammary epithelium during pregnancy may be driven through cyclin D1...
  11. pmc A unique pattern of photoreceptor degeneration in cyclin D1 mutant mice
    C Ma
    Howard Hughes Medical Institute and Department of Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 95:9938-43. 1998
    ..We also tested whether expression of a bcl-2 transgene could prevent the death and found that it could not...
  12. ncbi p21-activated kinase-1 signaling mediates cyclin D1 expression in mammary epithelial and cancer cells
    Seetharaman Balasenthil
    Department of Molecular and Cellular Oncology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 279:1422-8. 2004
    ....
  13. pmc A whole-genome mouse BAC microarray with 1-Mb resolution for analysis of DNA copy number changes by array comparative genomic hybridization
    Yeun Jun Chung
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    Genome Res 14:188-96. 2004
    ..The resulting 3K mouse BAC microarrays reproducibly identified DNA copy number alterations in cell lines and primary tumors, such as single-copy deletions, regional amplifications, and aneuploidy...
  14. pmc Interactions between Sox9 and beta-catenin control chondrocyte differentiation
    Haruhiko Akiyama
    Department of Molecular Genetics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Genes Dev 18:1072-87. 2004
    ..Our results strongly suggest that chondrogenesis is controlled by interactions between Sox9 and the Wnt/beta-catenin signaling pathway...
  15. pmc An extracellular signal-regulated kinase 1- and 2-dependent program of chromatin trafficking of c-Fos and Fra-1 is required for cyclin D1 expression during cell cycle reentry
    Peter M Burch
    Department of Pathology, Vermont Cancer Center, HSRF 328, University of Vermont College of Medicine, 89 Beaumont Ave, Burlington, VT 05405, USA
    Mol Cell Biol 24:4696-709. 2004
    ..Our data indicate that termination of nuclear ERK1,2 signaling is required for an exchange of Fra-1 for c-Fos on chromatin and initiation of cyclin D1 expression at the G(0)-to-G(1) transition of the cell cycle...
  16. pmc Cyclin D1 genetic heterozygosity regulates colonic epithelial cell differentiation and tumor number in ApcMin mice
    James Hulit
    The Lombardi Comprehensive Cancer Center, Department of Oncology, Georgetown University, Research Building Room E501, 3970 Reservoir Rd, N W, Box 571468, Washington, DC 20057 1468, USA
    Mol Cell Biol 24:7598-611. 2004
    ..The protection of mice, genetically predisposed to intestinal tumorigenesis, through cyclin D1 heterozygosity suggests that modalities that reduce cyclin D1 abundance could provide chemoprotection...
  17. ncbi Mouse development and cell proliferation in the absence of D-cyclins
    Katarzyna Kozar
    Department of Cancer Biology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Cell 118:477-91. 2004
    ..Lastly, we found that cells lacking D-cyclins display reduced susceptibility to the oncogenic transformation. Our results reveal the presence of alternative mechanisms that allow cell cycle progression in a cyclin D-independent fashion...
  18. ncbi Synergy between LRH-1 and beta-catenin induces G1 cyclin-mediated cell proliferation
    Oronza A Botrugno
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique, Institut National de la Sante et de la Recherche Medicale, Universite Louis Pasteur, 67404 Illkirch, France
    Mol Cell 15:499-509. 2004
    ..The implication of LRH-1 in cell proliferation highlights an unanticipated crosstalk between LRH-1 and the beta-catenin/Tcf4 signaling pathway, which is relevant for the renewal of intestinal crypt cells...
  19. pmc Genetic replacement of cyclin D1 function in mouse development by cyclin D2
    Bradley C Carthon
    Department of Cancer Biology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
    Mol Cell Biol 25:1081-8. 2005
    ..We reason that the acquisition of multiple D cyclins may allow mammalian cells to drive optimal proliferation of a diverse array of cell types...
  20. ncbi Cyclin D1-dependent kinase activity in murine development and mammary tumorigenesis
    Mark W Landis
    Molecular Oncology Research Institute and Department of Radiation Oncology, Tufts New England Medical Center, 750 Washington Street 5609, Boston, Massachusetts 02111, USA
    Cancer Cell 9:13-22. 2006
    ..These results demonstrate a differential requirement for cyclin D1-CDK4/6 kinase activity in development versus tumorigenesis and strongly support cyclin D1-dependent kinase activity as a specific therapeutic target in breast cancer...
  21. ncbi Notch 1 inhibits photoreceptor production in the developing mammalian retina
    Ashutosh P Jadhav
    Department of Genetics and Howard Hughes Medical Institute, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Development 133:913-23. 2006
    ..These cone enriched mutant mice should prove to be a valuable resource for the study of this relatively rare mammalian photoreceptor cell type...
  22. pmc Caveolin-1 mutations in human breast cancer: functional association with estrogen receptor alpha-positive status
    Tianhong Li
    Department of Cancer Biology, Kimmel Cancer Center, Bluemle Life Sciences Building, Room 933, 233 S 10th Street, Philadelphia, PA 19107, USA
    Am J Pathol 168:1998-2013. 2006
    ..Finally, we discuss the possibility that sporadic Cav-1 mutations may act as an initiating event in human breast cancer pathogenesis...
  23. pmc Cyclin D1 repression of nuclear respiratory factor 1 integrates nuclear DNA synthesis and mitochondrial function
    Chenguang Wang
    Department of Cancer Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Proc Natl Acad Sci U S A 103:11567-72. 2006
    ..Cyclin D1-dependent kinase phosphorylates NRF-1 at S47. Cyclin D1 abundance thus coordinates nuclear DNA synthesis and mitochondrial function...
  24. ncbi Notch1-induced transformation of RKE-1 cells requires up-regulation of cyclin D1
    Mark Stahl
    Department of Cell Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Cancer Res 66:7562-70. 2006
    ..We report here that transformation of RKE-ER-N(ic) cells is dependent on increased expression of cyclin D1 protein, which represents a new mechanism of Notch1-induced transformation...
  25. pmc Stromal and epithelial caveolin-1 both confer a protective effect against mammary hyperplasia and tumorigenesis: Caveolin-1 antagonizes cyclin D1 function in mammary epithelial cells
    Terence M Williams
    Department of Cancer Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Am J Pathol 169:1784-801. 2006
    ..Thus, Cav-1 expression in both epithelial and stromal cells provides a protective effect against mammary hyperplasia as well as mammary tumorigenesis...
  26. pmc Wnt3a regulates Lef-1 expression during airway submucosal gland morphogenesis
    Ryan R Driskell
    Department of Anatomy and Cell Biology, Iowa City, IA 52242, USA
    Dev Biol 305:90-102. 2007
    ..These findings provide the first in vivo evidence that Wnt3a can transcriptionally regulate the Lef-1 gene...
  27. ncbi Redox control of G(1)/S cell cycle regulators during nitric oxide-mediated cell cycle arrest
    Qi Lu
    Center for Cardiovascular Sciences, Albany Medical College, Albany, NY 12208, USA
    J Cell Physiol 212:827-39. 2007
    ..Together, our results demonstrate that GSH serves as an important component of cellular protective mechanisms against NO-derived nitrosative stress to regulate DNA damage checkpoint...
  28. pmc The LIM-only protein FHL2 regulates cyclin D1 expression and cell proliferation
    Charlotte Labalette
    Unité d Oncogenèse et Virologie Moléculaire and PT Puce à ADN, Institut Pasteur, 28 rue du Dr Roux, 75015 Paris, France
    J Biol Chem 283:15201-8. 2008
    ..Our study illustrates that FHL2 can act on different aspects of the cell cycle program to finely regulate cell proliferation...
  29. ncbi A novel cyclin encoded by a bcl1-linked candidate oncogene
    T Motokura
    Endocrine Unit, Massachusetts General Hospital, Boston
    Nature 350:512-5. 1991
    We have previously identified a candidate oncogene (PRAD1 or D11S287E) on chromosome 11q13 which is clonally rearranged with the parathyroid hormone locus in a subset of benign parathyroid tumours...
  30. ncbi Mice lacking cyclin D1 are small and show defects in eye and mammary gland development
    V Fantl
    Laboratory of Viral Carcinogenesis, Imperial Cancer Research Fund ICRF, London, UK
    Genes Dev 9:2364-72. 1995
    ..Thus although cyclin D1 kinase activity may facilitate G1 progression, it is not essential for the development of most tissues and organs, and only a few specialized cell lineages are demonstrably sensitive to its absence...
  31. pmc Cyclin D1 transgene impedes lymphocyte maturation and collaborates in lymphomagenesis with the myc gene
    S E Bodrug
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria 3050, Australia
    EMBO J 13:2124-30. 1994
    ..These findings indicate that this G1 cyclin can modulate differentiation and collaborate with myc-like genes in oncogenesis...
  32. pmc Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization
    J A Diehl
    Howard Hughes Medical Institute, St Jude Children s Research Hospital, Memphis, Tennessee 38105 USA
    Genes Dev 12:3499-511. 1998
    ..Therefore, phosphorylation and proteolytic turnover of cyclin D1 and its subcellular localization during the cell division cycle are linked through the action of GSK-3beta...
  33. ncbi Rescue of cyclin D1 deficiency by knockin cyclin E
    Y Geng
    Dana Farber Cancer Institute, and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 97:767-77. 1999
    ..We have generated a mouse strain in which the coding sequences of the cyclin D1 gene (Ccnd1) have been deleted and replaced by those of human cyclin E (CCNE)...
  34. ncbi Loss of p27Kip1 function results in increased proliferative capacity of oligodendrocyte progenitors but unaltered timing of differentiation
    P Casaccia-Bonnefil
    Molecular Neurobiology, Skirball Institute for Biomolecular Medicine at NYU Medical Center, New York, NY 10016, USA nyu edu
    Development 126:4027-37. 1999
    ....
  35. ncbi Specific protection against breast cancers by cyclin D1 ablation
    Q Yu
    Department of Cancer Biology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 411:1017-21. 2001
    ..Our results suggest that an anti-cyclin D1 therapy might be highly specific in treating human breast cancers with activated Neu-Ras pathways...
  36. ncbi Persistent expression of cyclin D1 disrupts normal photoreceptor differentiation and retina development
    S X Skapek
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Oncogene 20:6742-51. 2001
    ..These findings are distinct from other mouse models in which the retinoblastoma gene pathway is disrupted and suggest that the IRBP-cyclin D1 mouse model may recapitulate an early step in the development of retinoblastoma...
  37. ncbi Genetic manipulation of hedgehog signaling in the endochondral skeleton reveals a direct role in the regulation of chondrocyte proliferation
    F Long
    Harvard University, Department of Molecular and Cellular Biology, Cambridge, MA 02138, USA
    Development 128:5099-108. 2001
    ..Taken together, the present study establishes Ihh as a key mitogen in the endochondral skeleton...
  38. pmc Development of mice expressing a single D-type cyclin
    Maria A Ciemerych
    Department of Cancer Biology, Dana Farber Cancer Institute and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 16:3277-89. 2002
    ..Hence, the requirement for a particular cyclin in a given tissue is likely caused by specific transcription factors, rather than by unique properties of cyclins...
  39. ncbi Cyclin D1 splice variants. Differential effects on localization, RB phosphorylation, and cellular transformation
    David A Solomon
    Department of Cell Biology, University of Cincinnati, Vontz Center for Molecular Studies, Cincinnati, Ohio 45267 0521, USA
    J Biol Chem 278:30339-47. 2003
    ..In summary, we demonstrate that cyclin D1b specifically disrupts contact inhibition in a manner distinct from cyclin D1a. These data reveal novel roles for d-type cyclins in tumorigenesis...
  40. pmc Cyclin D1 repression of peroxisome proliferator-activated receptor gamma expression and transactivation
    Chenguang Wang
    Department of Oncology, Lombardi Cancer Center, Georgetown University, Washington, D C 20007, USA
    Mol Cell Biol 23:6159-73. 2003
    ..The inhibition of PPAR gamma function by cyclin D1 is a new mechanism of signal transduction cross talk between PPAR gamma ligands and mitogenic signals that induce cyclin D1...
  41. ncbi Role of cyclin D1 cytoplasmic sequestration in the survival of postmitotic neurons
    Piyamas Sumrejkanchanakij
    Section of Molecular Embryology, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8549, Japan
    Oncogene 22:8723-30. 2003
    ..These results indicate that nuclear accumulation of cyclin D1 is inhibited in postmitotic neurons and suggest a role of its subcellular localization in neuronal death and survival...
  42. ncbi Mammalian cells cycle without the D-type cyclin-dependent kinases Cdk4 and Cdk6
    Marcos Malumbres
    Molecular Oncology Program, Centro Nacional de Investigaciones Oncologicas CNIO, E 28029 Madrid, Spain
    Cell 118:493-504. 2004
    ..These results indicate that D-type cyclin-dependent kinases are not essential for cell cycle entry and suggest the existence of alternative mechanisms to initiate cell proliferation upon mitogenic stimulation...
  43. pmc Beta cell replication is the primary mechanism for maintaining postnatal beta cell mass
    Senta Georgia
    Department of Biochemistry and Molecular Biology, University of Southern California, Developmental Biology Program, Saban Research Institute, Children s Hospital Los Angeles, Los Angeles, California 90027, USA
    J Clin Invest 114:963-8. 2004
    ....
  44. pmc Transcriptional regulation by a DNA-associated form of cyclin D1
    Frédéric Bienvenu
    INSERM U564, Cancer Center Paul Papin, Angers, France
    Mol Biol Cell 16:1850-8. 2005
    ..Altogether, these results suggest that the transcriptional activities of cyclin D1 might play an important role in the regulation of cell-cycle regulatory genes and that these functions are probably involved in cell transformation...
  45. ncbi Cyclin D1 inhibits peroxisome proliferator-activated receptor gamma-mediated adipogenesis through histone deacetylase recruitment
    Maofu Fu
    Lombardi Comprehensive Cancer Center, Department of Oncology, Georgetown University, Washington, D C 20057, USA
    J Biol Chem 280:16934-41. 2005
    ....
  46. ncbi Increased cyclin E expression may obviate the role of cyclin D1 during brain development in cyclin D1 knockout mice
    Zhiguo Chen
    Division of Experimental Geriatrics, Department of Neurotec, Karolinska Institutet, Karolinska University Hospital, Huddinge, Sweden
    J Neurochem 92:1281-4. 2005
    ..The data indicate that enhanced cyclin E protein expression in cyclin D1 KO mice may obviate the role of cyclin D1 and contribute to the normal brain development of cyclin D1 KO mice...
  47. ncbi Cell cycle progression without cyclin D-CDK4 and cyclin D-CDK6 complexes
    Katarzyna Kozar
    Department of Cancer Biology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA
    Cell Cycle 4:388-91. 2005
    ..Intriguingly, several compartments can develop in the absence of cyclin D-CDK4/6 activity, revealing that these cells can proliferate in a cyclin D-independent fashion...
  48. pmc The role of Axin2 in calvarial morphogenesis and craniosynostosis
    Hsiao Man Ivy Yu
    Center for Oral Biology, Department of Biomedical Genetics, Abs Institute of Biomedical Sciences, School of Medicine and Dentistry, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Development 132:1995-2005. 2005
    ..The craniofacial anomalies caused by the Axin2 mutation are mediated through activation of beta-catenin signaling, suggesting a novel role for the Wnt pathway in skull morphogenesis...
  49. ncbi Cyclin D1 represses p300 transactivation through a cyclin-dependent kinase-independent mechanism
    Maofu Fu
    Lombardi Comprehensive Cancer Center, Department of Oncology, Georgetown University, Washington, DC 20057, USA
    J Biol Chem 280:29728-42. 2005
    ..Together, our results suggest that cyclin D1 plays an important role in cellular proliferation and differentiation through regulation of p300...
  50. ncbi Shh controls epithelial proliferation via independent pathways that converge on N-Myc
    Pleasantine Mill
    Department of Medical and Molecular Genetics, University of Toronto, Toronto, Ontario M5G 1X8, Canada
    Dev Cell 9:293-303. 2005
    ..These findings demonstrate that Shh signaling controls the rapid and patterned expansion of epithelial progenitors through convergent Gli-mediated regulation...
  51. ncbi Beta-catenin is essential for pancreatic acinar but not islet development
    L Charles Murtaugh
    Department of Molecular and Cellular Biology and Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA
    Development 132:4663-74. 2005
    ..Thus, our data are consistent with a crucial role for canonical Wnt signals in acinar lineage specification and differentiation...
  52. ncbi Retinal ganglion cell-derived sonic hedgehog locally controls proliferation and the timing of RGC development in the embryonic mouse retina
    Yaping Wang
    Molecular Medicine Program, Ottawa Health Research Institute and University of Ottawa Eye Institute, 501 Smyth Road, Ottawa, Ontario K1H 8L6, Canada
    Development 132:5103-13. 2005
    ....
  53. pmc Expression of constitutively nuclear cyclin D1 in murine lymphocytes induces B-cell lymphoma
    A B Gladden
    The Abramson Family Cancer Research Institute, Department of Cancer Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Oncogene 25:998-1007. 2006
    ..Our results describe a cyclin D1-driven model of B-cell lymphomagenesis and provide evidence that nuclear-retention of cyclin D1 is oncogenic in vivo...
  54. ncbi Patched1 functions as a gatekeeper by promoting cell cycle progression
    Christelle Adolphe
    Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia
    Cancer Res 66:2081-8. 2006
    ..In addition, we note the high frequency and rapid onset of tumors in this mouse model makes it an ideal system for testing therapeutic strategies, such as Patched pathway inhibitors...
  55. pmc Cyclin D1 regulates cellular migration through the inhibition of thrombospondin 1 and ROCK signaling
    Zhiping Li
    Thomas Jefferson University, Department of Cancer Biology, Kimmel Cancer Center, Bluemle Building, Rm 1050, 233 South 10th St, Philadelphia, PA 19107, USA
    Mol Cell Biol 26:4240-56. 2006
    ..Cyclin D1 promotes cellular motility through inhibiting ROCK signaling and repressing the metastasis suppressor TSP-1...
  56. ncbi BM88 is a dual function molecule inducing cell cycle exit and neuronal differentiation of neuroblastoma cells via cyclin D1 down-regulation and retinoblastoma protein hypophosphorylation
    Niki Georgopoulou
    Laboratory of Cellular and Molecular Neurobiology, Hellenic Pasteur Institute, 127 Vassilissis Sofias Avenue, 115 21 Athens, Greece
    J Biol Chem 281:33606-20. 2006
    ....
  57. pmc Loss of cyclin D1 impairs cerebellar development and suppresses medulloblastoma formation
    Jennifer Pogoriler
    Ben May Institute for Cancer Research, The University of Chicago, Chicago, IL 60637, USA
    Development 133:3929-37. 2006
    ..Coinciding with the period of cyclin D1-only expression, Ccnd1(-/-) mice showed reduced proliferation of GNPs and impaired growth of the cerebellum...
  58. pmc Phosphorylation-dependent ubiquitination of cyclin D1 by the SCF(FBX4-alphaB crystallin) complex
    Douglas I Lin
    The Leonard and Madlyn Abramson Family Cancer Research Institute and Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Mol Cell 24:355-66. 2006
    ..We conclude that SCF(FBX4-alphaB crystallin) is an E3 ubiquitin ligase that promotes ubiquitin-dependent degradation of Thr286-phosphorylated cyclin D1...
  59. pmc Impaired neural development caused by inducible expression of Axin in transgenic mice
    Hsiao Man Ivy Yu
    Department of Biomedical Genetics, Center for Oral Biology, Abs Institute of Biomedical Sciences, School of Medicine and Dentistry, University of Rochester, 601 Elmwood Avenue, Box 611, Rochester, NY 14642, USA
    Mech Dev 124:146-56. 2007
    ..Our data support the conclusion that the development of embryonic neural axis is highly sensitive to the level of Wnt signaling...
  60. ncbi Can the cardiomyocyte cell cycle be reprogrammed?
    Katrina A Bicknell
    School of Pharmacy, University of Reading, PO Box 226 Whiteknights, Reading Berkshire RG6 6AP, UK
    J Mol Cell Cardiol 42:706-21. 2007
    ..The validity of therapeutic strategies that aim to reinstate the proliferative potential of cardiomyocytes to improve myocardial repair following injury will be discussed...
  61. ncbi Cyclin D1 as a target for the proliferative effects of PTH and PTHrP in early osteoblastic cells
    Nabanita S Datta
    Department of Periodontics and Oral Medicine, University of Michigan, Ann Arbor, Michigan 48109 1078, USA
    J Bone Miner Res 22:951-64. 2007
    ..In ectopic ossicles generated from implanted bone marrow stromal cells, PTH upregulated cyclin D1 after acute or intermittent anabolic treatment. These data suggest a positive role of PTH and PTHrP in the cell cycle of early osteoblasts...
  62. pmc Negative regulation of Vsx1 by its paralog Chx10/Vsx2 is conserved in the vertebrate retina
    Anna M Clark
    Department of Ophthalmology and Visual Sciences, John A Moran Eye Center, University of Utah, Salt Lake City, UT, USA
    Brain Res 1192:99-113. 2008
    ....
  63. doi Alternate cyclin D1 mRNA splicing modulates p27KIP1 binding and cell migration
    Zhiping Li
    Kimmel Cancer Center, Department of Cancer Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 283:7007-15. 2008
    ..Our findings argue that alternate splicing is an important determinant of the function of cyclin D1 in cellular migration...
  64. pmc Alternative promoter use in eye development: the complex role and regulation of the transcription factor MITF
    Kapil Bharti
    Mammalian Development Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Development 135:1169-78. 2008
    ....
  65. pmc Phosphorylation of cyclin D1 regulated by ATM or ATR controls cell cycle progression
    Masahiro Hitomi
    Department of Molecular Genetics, The Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Mol Cell Biol 28:5478-93. 2008
    ..These results indicate that checkpoint kinases play a critical role in regulating cell cycle progression in normal and stressed cells by directing the phosphorylation of cyclin D1...
  66. doi Differential requirement for beta-catenin in epithelial and fiber cells during lens development
    Sarah Cain
    Ocular Development Laboratory, Anatomy and Cell Biology Department, University of Melbourne, Victoria 3010, Australia
    Dev Biol 321:420-33. 2008
    ..These data indicate that beta-catenin plays distinct functions during lens fiber differentiation and is involved in both Wnt signaling and adhesion-related mechanisms that regulate lens epithelium and early fiber differentiation...
  67. pmc Genotoxic stress-induced cyclin D1 phosphorylation and proteolysis are required for genomic stability
    Laura L Pontano
    Department of Cancer Biology, The Abramson Family Cancer Research Institute, 454 BRB II III, Philadelphia, PA 19104 6140, USA
    Mol Cell Biol 28:7245-58. 2008
    ..These data suggest that failure to degrade cyclin D1 compromises the intra-S-phase checkpoint and suggest that cyclin D1 degradation is a vital cellular response necessary to prevent genomic instability following genotoxic insult...
  68. pmc Cyclin D1 fine-tunes the neurogenic output of embryonic retinal progenitor cells
    Gaurav Das
    Department of Ophthalmology and Visual Sciences, John A Moran Eye Center, University of Utah, Salt Lake City, UT 84132, USA
    Neural Dev 4:15. 2009
    ..cell cycle regulator cyclin D1 is expressed in RPCs, and mice with a targeted null allele at the cyclin D1 locus (Ccnd1-/-) have microphthalmia and hypocellular retinas, the latter phenotype attributed to reduced RPC proliferation and ..
  69. pmc Cyclin D2 is critical for intermediate progenitor cell proliferation in the embryonic cortex
    Sara B Glickstein
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Neurosci 29:9614-24. 2009
    Expression of cyclins D1 (cD1) and D2 (cD2) in ventricular zone and subventricular zone (SVZ), respectively, suggests that a switch to cD2 could be a requisite step in the generation of cortical intermediate progenitor cells (IPCs)...
  70. doi Cdk4/cyclinD1 overexpression in neural stem cells shortens G1, delays neurogenesis, and promotes the generation and expansion of basal progenitors
    Christian Lange
    DFG Research Center and Cluster of Excellence for Regenerative Therapies Dresden CRTD, Medical Faculty, Technische Universität Dresden c o Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany
    Cell Stem Cell 5:320-31. 2009
    ..Thus, G1 lengthening is necessary and sufficient to switch neural progenitors to neurogenesis, and overexpression of cdk4/cyclinD1 can be used to increase progenitor expansion and, perhaps, cortical surface area...
  71. doi Cell cycle regulation in the inner ear sensory epithelia: role of cyclin D1 and cyclin-dependent kinase inhibitors
    Heidi Laine
    Institute of Biotechnology, University of Helsinki, 00014 Helsinki, Finland
    Dev Biol 337:134-46. 2010
    ..Thus, cyclin D1 critically contributes to the proliferative plasticity of supporting cells. These data suggest that targeted cyclin D1 induction in supporting cells might be an avenue for proliferative regeneration in the inner ear...
  72. pmc The transcription factor Foxg1 regulates the competence of telencephalic cells to adopt subpallial fates in mice
    Martine Manuel
    Genes and Development Group, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK
    Development 137:487-97. 2010
    ..These findings indicate that, in addition to regulating the production of ventralising signals, Foxg1 acts cell-autonomously in the telencephalon to ensure that cells develop the competence to adopt ventral identities...
  73. pmc Transcriptional role of cyclin D1 in development revealed by a genetic-proteomic screen
    Frédéric Bienvenu
    Department of Cancer Biology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Nature 463:374-8. 2010
    ..of the Notch1 promoter region, and led to decreased levels of the Notch1 transcript and protein in cyclin D1-null (Ccnd1(-/-)) retinas...
  74. pmc Temporal requirement of the protein tyrosine phosphatase Shp2 in establishing the neuronal fate in early retinal development
    Zhigang Cai
    Department of Medical and Molecular Genetics, Stark Neuroscience Institute, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Neurosci 30:4110-9. 2010
    ..Together, these results demonstrate that Shp2 mediates FGF-Ras signaling to control retinal progenitor cell fate...
  75. pmc Cyclin D1 regulates hepatic estrogen and androgen metabolism
    Lisa K Mullany
    Division of Gastroenterology, Hennepin County Medical Center, 701 Park Ave, Minneapolis, MN 55415, USA
    Am J Physiol Gastrointest Liver Physiol 298:G884-95. 2010
    ..Furthermore, these results suggest that increased cyclin D1 expression, which occurs in liver regeneration and liver diseases, may contribute to the feminization seen in these settings...
  76. doi Coordinated regulation of differentiation and proliferation of embryonic cardiomyocytes by a jumonji (Jarid2)-cyclin D1 pathway
    Kuniko Nakajima
    Mitsubishi Kagaku Institute of Life Sciences, Machida 194 8511, Japan
    Development 138:1771-82. 2011
    ..Thus, a Jmj-cyclin D1 pathway coordinately regulates proliferation and differentiation of cardiomyocytes...
  77. pmc Overexpression of cdk4 and cyclinD1 triggers greater expansion of neural stem cells in the adult mouse brain
    Benedetta Artegiani
    German Research Foundation Research Center and Cluster of Excellence for Regenerative Therapies, Medical Faculty, Dresden University of Technology, 01307 Dresden, Germany
    J Exp Med 208:937-48. 2011
    ....
  78. pmc ChIP sequencing of cyclin D1 reveals a transcriptional role in chromosomal instability in mice
    Mathew C Casimiro
    Department of Cancer Biology, Thomas Jefferson University and Hospital, Kimmel Cancer Center, Philadelphia, Pennsylvania 19107, USA
    J Clin Invest 122:833-43. 2012
    ..b>CCND1 (which encodes cyclin D1) is overexpressed in human malignancies and has been shown to play a direct role in ..
  79. pmc Cyclin D1 inactivation extends proliferation and alters histogenesis in the postnatal mouse retina
    Gaurav Das
    Departments of Ophthalmology and Visual Sciences, and Neurobiology and Anatomy, John A Moran Eye Center, University of Utah, Salt Lake City, UT, USA
    Dev Dyn 241:941-52. 2012
    ..We report here that Cyclin D1 also has important functions in postnatal retinal histogenesis...
  80. pmc Activation of the hedgehog signaling pathway in the developing lens stimulates ectopic FoxE3 expression and disruption in fiber cell differentiation
    Christine L Kerr
    Department of Pathology and Molecular Medicine, McMaster University Health Sciences Centre, Hamilton, Ontario, Canada
    Invest Ophthalmol Vis Sci 53:3316-30. 2012
    ..Hedgehog signaling is implicated in eye development, and defects in hedgehog signaling components have been shown to result in defects of the retina, iris, and lens...
  81. pmc Snf2l regulates Foxg1-dependent progenitor cell expansion in the developing brain
    Darren J Yip
    Regenerative Medicine Program, Ottawa Hospital Research Institute, and Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, ON, Canada
    Dev Cell 22:871-8. 2012
    ..We demonstrate that Snf2l binds to the Foxg1 locus at midneurogenesis and that the phenotype is rescued by reducing Foxg1 dosage, thus revealing that Snf2l and Foxg1 function antagonistically to regulate brain size...
  82. pmc The requirement for cyclin D function in tumor maintenance
    Yoon Jong Choi
    Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA 02215, USA
    Cancer Cell 22:438-51. 2012
    ..Inhibition of cyclin D-kinase activity represents a highly-selective anticancer strategy that specifically targets cancer cells without significantly affecting normal tissues...
  83. pmc Foxg1 is required to limit the formation of ciliary margin tissue and Wnt/β-catenin signalling in the developing nasal retina of the mouse
    Vassiliki Fotaki
    University of Edinburgh, Centre for Integrative Physiology, Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK
    Dev Biol 380:299-313. 2013
    ..Our results reveal a new role of Foxg1 in limiting CM development in the nasal peripheral retina and add a new molecular player in the developmental network involved in CM specification...
  84. pmc Phosphorylation-dependent regulation of cyclin D1 nuclear export and cyclin D1-dependent cellular transformation
    J R Alt
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
    Genes Dev 14:3102-14. 2000
    ..Thus, removal of cyclin D1 from the nucleus during S phase appears essential for regulated cell division...
  85. ncbi p27Kip1 and p57Kip2 regulate proliferation in distinct retinal progenitor cell populations
    M A Dyer
    Department of Genetics and Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 21:4259-71. 2001
    ....
  86. ncbi Nmyc upregulation by sonic hedgehog signaling promotes proliferation in developing cerebellar granule neuron precursors
    Anna Marie Kenney
    Department of Pediatric Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA
    Development 130:15-28. 2003
    ..Together, these findings identify Nmyc as a direct target of the Shh pathway that functions to regulate cell cycle progression in cerebellar granule neuron precursors...
  87. ncbi Short term cyclin D1 overexpression induces centrosome amplification, mitotic spindle abnormalities, and aneuploidy
    Christopher J Nelsen
    Division of Gastroenterology, Hennepin County Medical Center, Minneapolis, Minnesota 55415, USA
    J Biol Chem 280:768-76. 2005
    ..These results indicate that cyclin D1 can induce deregulation of the mitotic apparatus and aneuploidy, effects that could contribute to the role of this oncogene in malignancy...
  88. ncbi Akt induces beta-cell proliferation by regulating cyclin D1, cyclin D2, and p21 levels and cyclin-dependent kinase-4 activity
    Szabolcs Fatrai
    Division of Endocrinology, Metabolism, and Lipid Research, Washington University School of Medicine, St Louis, MO 63110, USA
    Diabetes 55:318-25. 2006
    ..These data also indicate that alteration in levels of these cell cycle components could affect the maintenance of beta-cell mass in basal states and the adaptation of beta-cells to pathological states resulting in diabetes...
  89. pmc Compensation by tumor suppressor genes during retinal development in mice and humans
    Stacy L Donovan
    Department of Developmental Neurobiology, St, Jude Children s Research Hospital, Memphis, TN 38105, USA
    BMC Biol 4:14. 2006
    ..In this manuscript, we explore the different roles of the Rb family in human and mouse retinal development in order to better understand the species-specific difference in retinoblastoma susceptibility...
  90. ncbi Elimination of cyclin D1 in vertebrate cells leads to an altered cell cycle phenotype, which is rescued by overexpression of murine cyclins D1, D2, or D3 but not by a mutant cyclin D1
    J M Lahti
    Department of Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Biol Chem 272:10859-69. 1997
    ..Thus, there may be distinct differences in cyclin D1 complexes and/or its target(s) in proliferating and apoptotic DT40 lymphoma B-cells...
  91. pmc Genetic evidence for the interactions of cyclin D1 and p27(Kip1) in mice
    W Tong
    Department of Developmental and Molecular Biology, Center for the Study of Reproductive Biology and Women s Health, Albert Einstein College of Medicine, New York, New York 10461, USA
    Mol Cell Biol 21:1319-28. 2001
    ..It also supports the suggestion that the cyclin E/Cdk2 pathway can largely bypass Rb in regulating the cell cycle in vivo...
  92. ncbi Impaired mammary gland development in Cyl-1(-/-) mice during pregnancy and lactation is epithelial cell autonomous
    V Fantl
    Viral Carcinogenesis Laboratory, Histopathology Unit, Imperial Cancer Research Fund, 44 Lincoln s Inn Fields, London, WC2A 3PX, United Kingdom
    Dev Biol 212:1-11. 1999
    ....
  93. pmc Deletion of the p27Kip1 gene restores normal development in cyclin D1-deficient mice
    Y Geng
    Department of Cancer Biology, Dana Farber Cancer Institute, and Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 98:194-9. 2001
    ..Here we report that ablation of p27(Kip1) restores essentially normal development in cyclin D1-deficient mice. Our results provide genetic evidence that p27(Kip1) functions downstream of cyclin D1...
  94. ncbi Schlafen-1 causes a cell cycle arrest by inhibiting induction of cyclin D1
    Gareth Brady
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
    J Biol Chem 280:30723-34. 2005
    ..Finally, overexpression of Slfn-1 inhibited the activation of the cyclin D1 promoter. Slfn-1 therefore causes a cell cycle arrest during G1 by inhibiting induction of cyclin D1 by mitogens...
  95. pmc Vsx2/Chx10 ensures the correct timing and magnitude of Hedgehog signaling in the mouse retina
    Crystal L Sigulinsky
    Department of Ophthalmology and Visual Sciences, John A Moran Eye Center, University of Utah, Salt Lake City, UT 84132, USA
    Dev Biol 317:560-75. 2008
    ..Our results suggest that reduced Hh signaling contributes to the reduced level of RPC proliferation in the orJ retina, thereby revealing a role for Vsx2 in mediating mitogen signaling...
  96. ncbi The SV40 small t-antigen prevents mammary gland differentiation and induces breast cancer formation in transgenic mice; truncated large T-antigen molecules harboring the intact p53 and pRb binding region do not have this effect
    F Goetz
    Institut fur Molekularbiologie und Biochemie, Freie Universitat Berlin, Arnimallee 22, 14195 Berlin, Germany
    Oncogene 20:2325-32. 2001
    ..Sequestration of p53 and pRb by the N-terminal truncated T-antigen molecules (T1-antigen and T2-antigen) does not affect mammary gland differentiation and the transgenic animals (WAP-SVBst-Bam) do not develop breast tumors...
  97. ncbi Ras-inducible immortalized fibroblasts: focus formation without cell cycle deregulation
    Kivin Jacobsen
    Department of Molecular Cell Biology, University of Copenhagen, DK 1353 Copenhagen, Denmark
    Oncogene 21:3058-67. 2002
    ....
  98. ncbi In vivo evidence that BMP signaling is necessary for apoptosis in the mouse limb
    Udayan Guha
    Department of Nueroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Dev Biol 249:108-20. 2002
    ..These abnormalities were rescued by coexpressing BMP4 under the same promoter in double transgenic mice, suggesting that the limb abnormalities are a direct effect of inhibiting BMP signaling...
  99. pmc Receptor activator of NF-kappaB ligand regulates the proliferation of mammary epithelial cells via Id2
    Nam Shik Kim
    Division of Molecular and Life Sciences, Pohang University of Science and Technology, Pohang 790 783, Kyungbuk, South Korea
    Mol Cell Biol 26:1002-13. 2006
    ..Our results indicate that the inhibitor of helix-loop-helix protein, Id2, is critical to control the proliferation of mammary epithelial cells in response to RANKL stimulation...
  100. doi Essential role of developmentally activated hypoxia-inducible factor 1alpha for cardiac morphogenesis and function
    Jaya Krishnan
    Institute of Cell Biology, Eidgenossische Technische Hochschule, Zurich, Switzerland
    Circ Res 103:1139-46. 2008
    ....
  101. pmc c-Jun/AP-1 pathway-mediated cyclin D1 expression participates in low dose arsenite-induced transformation in mouse epidermal JB6 Cl41 cells
    Dongyun Zhang
    Nelson Institute of Environmental Medicine, New York University School of Medicine, 57 Old Forge Road, Tuxedo, NY 10987, USA
    Toxicol Appl Pharmacol 235:18-24. 2009
    ..Collectively, our results demonstrate that c-Jun/AP-1-mediated cyclin D1 expression is at least one of the key events implicated in cell transformation upon low dose arsenite exposure...

Research Grants11

  1. ASBESTOS AND NO2 IN ENVIRONMENTAL LUNG DISEASE
    Nicholas Heintz; Fiscal Year: 2001
    ..Dissection of the role of cell cycle and survival regulators in proliferative and apoptotic responses to the combined effects of asbestos and N02 may lead to new biomarkers for exposure of the human lung to chemical mixtures. ..
  2. C/EBPB And Mitotic Clonal Expansion During Adipogenesis
    Qi Qun Tang; Fiscal Year: 2004
    ..identify the kinase(s) that catalyzes this/these phosphorylation/s and to determine how the kinase(s) is regulated. -determine the role of C/EBP-beta in mitotic clonal expansion and how phosphorylation of C/EBP-beta affects this role...
  3. ROLE OF CYCLINS D2 AND D3 IN LYPHIOD CELL PROLIFERATION
    Piotr Sicinski; Fiscal Year: 2004
    ..2) To determine the consequence of combined ablation of cyclins D2 and D3 for lymphoid development. (3) To determine the role for cyclins D2 and D3 in lymphoid malignancies. ..
  4. HAND GENES IN CARDIAC DEVELOPMENT
    William Pu; Fiscal Year: 2004
    ..This experience, and the information generated in this plan, will launch the applicant's career as an independent investigator. ..
  5. Mechanisms of endoderm specification along the A-P axis.
    James M Wells; Fiscal Year: 2010
    ..Additionally, this information should allow us to coax embryonic stem cells into becoming important transplantable derivatives of endoderm, such as insulin-producing beta cells to treat patients with Type 1 diabetes. ..
  6. ROLES OF SOX C GENES IN SKELETOGENESIS
    VERONIQUE M LEFEBVRE; Fiscal Year: 2010
    ....
  7. Chemoprevention in Mice after Tobacco Smoke Exposure
    Hanspeter Witschi; Fiscal Year: 2004
    ..Eventually, these preclinical studies in an animal model of "former smokers" will help to evaluate the potential usefulness and also possible dosage regimens of chemopreventive agents characterized by their suppressing action. ..
  8. Cyclin D1 and mammary carcinoma
    J Diehl; Fiscal Year: 2009
    ..The work proposed herein will establish the relationship between cyclin D1 nuclear retention and the function of cyclin D1 as an oncogenic protein in mammary carcinoma. ..
  9. Signaling Pathways in Proliferation and Differentiation
    MARK EWEN; Fiscal Year: 2009
    ..abstract_text> ..
  10. Cell cycle control of vascular remodeling
    RICHARD ASSOIAN; Fiscal Year: 2009
    ..This research will help to identify the genes and proteins that regulate smooth muscle cell proliferation. It will also test the importance of these molecules in an in vivo model of vascular injury. ..