Ccl9

Summary

Gene Symbol: Ccl9
Description: chemokine (C-C motif) ligand 9
Alias: CCF18, MRP-2, Scya10, Scya9, C-C motif chemokine 9, MIP-1 gamma, macrophage inflammatory protein 1-gamma, macrophage inflammatory protein-related protein 2, small inducible cytokine A10, small inducible cytokine A9
Species: mouse
Products:     Ccl9

Top Publications

  1. Durand C, Robin C, Bollerot K, Baron M, Ottersbach K, Dzierzak E. Embryonic stromal clones reveal developmental regulators of definitive hematopoietic stem cells. Proc Natl Acad Sci U S A. 2007;104:20838-43 pubmed
    ..We suggest that Bmp4 plays a relatively late role in the regulation of HSCs as they emerge in the midgestation AGM...
  2. Zhao X, Sato A, Dela Cruz C, Linehan M, Luegering A, Kucharzik T, et al. CCL9 is secreted by the follicle-associated epithelium and recruits dome region Peyer's patch CD11b+ dendritic cells. J Immunol. 2003;171:2797-803 pubmed
    ..Here, we describe another chemokine specifically secreted from the FAE of mouse Peyer's patches, CCL9 (MIP-1gamma, CCF18, MRP-2)...
  3. Youn B, Jang I, Broxmeyer H, Cooper S, Jenkins N, Gilbert D, et al. A novel chemokine, macrophage inflammatory protein-related protein-2, inhibits colony formation of bone marrow myeloid progenitors. J Immunol. 1995;155:2661-7 pubmed
    ..The MRP-2 gene termed Scya9 was mapped to the central region of mouse chromosome 11 near the Scya1 and Scya2 genes, which are also members of ..
  4. Cohen Tannoudji M, Vandormael Pournin S, Le Bras S, Coumailleau F, Babinet C, Baldacci P. A 2-Mb YAC/BAC-based physical map of the ovum mutant (Om) locus region on mouse chromosome 11. Genomics. 2000;68:273-82 pubmed
    ..Two other genes (Rad51l3 and Schlafen 2) and one EST (D11Wsu78e) were also mapped in the Om region. This integrated map provides support for the identification of additional candidate genes for the DDK syndrome. ..
  5. Hara T, Bacon K, Cho L, Yoshimura A, Morikawa Y, Copeland N, et al. Molecular cloning and functional characterization of a novel member of the C-C chemokine family. J Immunol. 1995;155:5352-8 pubmed
    ..Moreover, prior administration of MIP-1 alpha desensitized the cells to CCF18. The CCF18 gene (Scya10) was mapped to a middle region of murine chromosome 11, where other genes for several C-C chemokine members are ..
  6. Iotti G, Ferrari Amorotti G, Rosafio C, Corradini F, Lidonnici M, Ronchetti M, et al. Expression of CCL9/MIP-1gamma is repressed by BCR/ABL and its restoration suppresses in vivo leukemogenesis of 32D-BCR/ABL cells. Oncogene. 2007;26:3482-91 pubmed
    ..hybridization of polysomal RNA of untreated and STI571-treated 32D-BCR/ABL cells, we identified the beta-chemokine CCL9 as a gene regulated by BCR/ABL in a tyrosine kinase-dependent manner...
  7. Cottle D, Ursino G, Ip S, Jones L, DiTommaso T, Hacking D, et al. Fetal inhibition of inflammation improves disease phenotypes in harlequin ichthyosis. Hum Mol Genet. 2015;24:436-49 pubmed publisher
    ..These studies highlight inflammation as an unexpected contributor to HI disease development in utero, and suggest that inhibiting inflammation may reduce disease severity. ..
  8. Kanaya T, Hase K, Takahashi D, Fukuda S, Hoshino K, Sasaki I, et al. The Ets transcription factor Spi-B is essential for the differentiation of intestinal microfold cells. Nat Immunol. 2012;13:729-36 pubmed publisher
    ..Our study demonstrates that commitment to the intestinal M-cell lineage requires Spi-B as a candidate master regulator. ..
  9. Núñez V, Alameda D, Rico D, Mota R, Gonzalo P, Cedenilla M, et al. Retinoid X receptor alpha controls innate inflammatory responses through the up-regulation of chemokine expression. Proc Natl Acad Sci U S A. 2010;107:10626-31 pubmed publisher
    ..Here, we provide evidence that RXRalpha regulates the transcription of the chemokines Ccl6 and Ccl9 in macrophages independently of heterodimeric partners...

More Information

Publications28

  1. Okamatsu Y, Kim D, Battaglino R, Sasaki H, Späte U, Stashenko P. MIP-1 gamma promotes receptor-activator-of-NF-kappa-B-ligand-induced osteoclast formation and survival. J Immunol. 2004;173:2084-90 pubmed
    ..Taken together, these results demonstrate that MIP-1 gamma plays an important role in the differentiation and survival of osteoclasts, most likely via an autocrine pathway. ..
  2. Yu R, Park J, Kawada T, Kwon B. Alteration of a macrophages inflammatory protein-related protein-2 (MRP-2) response by high fat and cholesterol diet in mice. Life Sci. 2002;70:2535-45 pubmed
    ..These results suggest that MRP-2 may be an important contributing factor in the development of atherosclerosis. ..
  3. Fukuda S, Hanano Y, Iio M, Miura R, Yoshie O, Nomiyama H. Genomic organization of the genes for human and mouse CC chemokine LEC. DNA Cell Biol. 1999;18:275-83 pubmed
    ..with the human LEC cDNA was isolated from a BAC clone that also contained the CC chemokine genes for C10, MRP-2/CCF18/MIP-1gamma, and RANTES...
  4. Krulova M, Havelková H, Kosarová M, Holan V, Hart A, Demant P, et al. IL-2-induced proliferative response is controlled by loci Cinda1 and Cinda2 on mouse chromosomes 11 and 12: a distinct control of the response induced by different IL-2 concentrations. Genomics. 1997;42:11-5 pubmed
    ..Understanding the action of genetic factors, such as Cinda1 and Cinda2, that control T cell function is expected to contribute to the efficient analysis of the genetic control of susceptibility to infections and autoimmune diseases. ..
  5. Lean J, Murphy C, Fuller K, Chambers T. CCL9/MIP-1gamma and its receptor CCR1 are the major chemokine ligand/receptor species expressed by osteoclasts. J Cell Biochem. 2002;87:386-93 pubmed
    ..We found that RANKL induced expression of CCL9/MIP-1gamma to levels comparable to that of tartrate-resistant acid phosphatase (TRAP), a major specialized product ..
  6. Wilson G, Hewit K, Pallas K, Cairney C, Lee K, Hansell C, et al. Atypical chemokine receptor ACKR2 controls branching morphogenesis in the developing mammary gland. Development. 2017;144:74-82 pubmed publisher
    ..These data demonstrate that ACKR2 is an important regulator of branching morphogenesis in diverse biological contexts and provide the first evidence of a role for chemokines and their receptors in postnatal development processes. ..
  7. Meyer M, Hensbergen P, van der Raaij Helmer E, Brandacher G, Margreiter R, Heufler C, et al. Cross reactivity of three T cell attracting murine chemokines stimulating the CXC chemokine receptor CXCR3 and their induction in cultured cells and during allograft rejection. Eur J Immunol. 2001;31:2521-7 pubmed
    ..Chemokine mRNA levels exceeded those of CXCR3 and IFN-gamma which were induced with similar kinetics by several orders of magnitude. ..
  8. Teuscher C, Butterfield R, Ma R, Zachary J, Doerge R, Blankenhorn E. Sequence polymorphisms in the chemokines Scya1 (TCA-3), Scya2 (monocyte chemoattractant protein (MCP)-1), and Scya12 (MCP-5) are candidates for eae7, a locus controlling susceptibility to monophasic remitting/nonrelapsing experimental allergic enceph. J Immunol. 1999;163:2262-6 pubmed
    ..Similarly, cDNA sequence polymorphisms in Nos2, Scya3, Scya4, Scya5, Scya6, Scya7, Scya9, Scya10, and Scya11 were excluded as candidates for eae7...
  9. Yan H, Jiang J, Pang Y, Achyut B, Lizardo M, Liang X, et al. CCL9 Induced by TGFβ Signaling in Myeloid Cells Enhances Tumor Cell Survival in the Premetastatic Organ. Cancer Res. 2015;75:5283-98 pubmed publisher
    ..Here, we report that chemokine CCL9 was highly induced in Gr-1(+)CD11b(+) immature myeloid cells and in premetastatic lung in tumor-bearing mice...
  10. Ravindran C, Cheng Y, Liang S. CpG-ODNs induces up-regulated expression of chemokine CCL9 in mouse macrophages and microglia. Cell Immunol. 2010;260:113-8 pubmed publisher
    ..Here, we investigated the potential involvement of the chemokine CCL9 and its receptor CCR1 in the effects of CpG-ODNs on macrophage/microglial cells...
  11. Poltorak A, Bazzoni F, Smirnova I, Alejos E, Thompson P, Luheshi G, et al. MIP-1 gamma: molecular cloning, expression, and biological activities of a novel CC chemokine that is constitutively secreted in vivo. J Inflamm. 1995;45:207-19 pubmed
    ..As such it might, under normal circumstances, markedly influence responses to the inducible CC chemokines. ..
  12. Swamydas M, Ricci K, Rego S, Dreau D. Mesenchymal stem cell-derived CCL-9 and CCL-5 promote mammary tumor cell invasion and the activation of matrix metalloproteinases. Cell Adh Migr. 2013;7:315-24 pubmed publisher
    ..Results indicate that mesenchymal D1 cells produced concentrations of CCL5 and CCL9 4- to 5-fold higher than the concentrations secreted by 4T1 tumor cells (P < 0.01)...
  13. Ge Y, Waldemer R, Nalluri R, Nuzzi P, Chen J. RNAi screen reveals potentially novel roles of cytokines in myoblast differentiation. PLoS ONE. 2013;8:e68068 pubmed publisher
  14. Hu K, Luo S, Tong L, Huang X, Jin W, Huang W, et al. CCL19 and CCL28 augment mucosal and systemic immune responses to HIV-1 gp140 by mobilizing responsive immunocytes into secondary lymph nodes and mucosal tissue. J Immunol. 2013;191:1935-47 pubmed publisher
    ..Such enhancements appear to be associated with mobilization of responsive immunocytes into secondary lymphoid organs and mucosal tissues through interactions with corresponding receptors...
  15. Li J, Zhou Z, Zhang X, Zheng L, He D, Ye Y, et al. Inflammatory Molecule, PSGL-1, Deficiency Activates Macrophages to Promote Colorectal Cancer Growth through NF?B Signaling. Mol Cancer Res. 2017;15:467-477 pubmed publisher
    ..Mechanistically, increased production of the mouse chemokine ligand 9 (CCL9/MIP-1?) was found in the PSGL-1-deficient mice, and the macrophages are likely the major source of ..
  16. Simon L, Ekman G, Garcia T, Carnes K, Zhang Z, Murphy T, et al. ETV5 regulates sertoli cell chemokines involved in mouse stem/progenitor spermatogonia maintenance. Stem Cells. 2010;28:1882-92 pubmed publisher
    ..Rescue assays using recombinant chemokines indicated that C-C-motif ligand 9 (CCL9) facilitates Sertoli cell chemoattraction of stem/progenitor spermatogonia, which express C-C-receptor type 1 (CCR1)..
  17. Nardi V, Naveiras O, Azam M, Daley G. ICSBP-mediated immune protection against BCR-ABL-induced leukemia requires the CCL6 and CCL9 chemokines. Blood. 2009;113:3813-20 pubmed publisher
    ..We identify the chemokines CCL6 and CCL9 as genes prominently induced by the type I IFNs and ICSBP, and demonstrate that these immunomodulators are required ..
  18. Lomas Neira J, Chung C, Grutkoski P, Dunican A, Simms H, Cioffi W, et al. Divergent roles of murine neutrophil chemokines in hemorrhage induced priming for acute lung injury. Cytokine. 2005;31:169-79 pubmed
    ..These data suggest that KC and MIP-2alpha differ in their mediation of neutrophil function (apoptosis and chemotaxis) and contribution to the pathogenesis of lung injury following hemorrhage subsequent to sepsis. ..
  19. Berahovich R, Miao Z, Wang Y, Premack B, Howard M, Schall T. Proteolytic activation of alternative CCR1 ligands in inflammation. J Immunol. 2005;174:7341-51 pubmed
    ..Indeed, four such chemokines, CCL6/C10/MIP-related protein-1, CCL9/MIP-1gamma/MIP-related protein-2, CCL15/MIP-1delta/hemofiltrate CC chemokine-2/leukotactin-1, and CCL23/CKbeta8/..