Ccl5

Summary

Gene Symbol: Ccl5
Description: chemokine (C-C motif) ligand 5
Alias: MuRantes, RANTES, SISd, Scya5, TCP228, C-C motif chemokine 5, SIS-delta, T-cell-specific protein RANTES, small inducible cytokine A5, small-inducible cytokine A5
Species: mouse

Top Publications

  1. ncbi Inducible lung-specific expression of RANTES: preferential recruitment of neutrophils
    Z Z Pan
    Pulmonary and Critical Care Section, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Am J Physiol Lung Cell Mol Physiol 279:L658-66. 2000
  2. ncbi Role of RANTES in the development of autoimmune tissue injuries in MRL-Fas lpr mice
    Tsunemichi Tsukahara
    Department of Medicine and Clinical Oncology, Chiba University Graduate School of Medicine, Chiba, Japan
    Clin Immunol 103:89-97. 2002
  3. ncbi GM-CSF DNA induces specific patterns of cytokines and chemokines in the skin: implications for DNA vaccines
    Miguel Angel Perales
    The Swim Across America Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Cytokines Cell Mol Ther 7:125-33. 2002
  4. pmc Involvement of the chemokine RANTES (CCL5) in resistance to experimental infection with Leishmania major
    Helton da Costa Santiago
    Departamento de Bioquimica e Imunologia, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Brazil
    Infect Immun 72:4918-23. 2004
  5. pmc The K1 serotype capsular polysaccharide of Porphyromonas gingivalis elicits chemokine production from murine macrophages that facilitates cell migration
    Gabriela d'Empaire
    Department of Oral Biology and Periodontology, Goldman School of Dental Medicine, Boston University Medical Center, MA 02118, USA
    Infect Immun 74:6236-43. 2006
  6. ncbi Y-box binding protein-1 controls CC chemokine ligand-5 (CCL5) expression in smooth muscle cells and contributes to neointima formation in atherosclerosis-prone mice
    Regina Krohn
    Institute for Molecular Cardiovascular Research, University Hospital Aachen, RWTH Aachen University, Aachen, Germany
    Circulation 116:1812-20. 2007
  7. ncbi Relative role of CSF-1, MCP-1/JE, and RANTES in macrophage recruitment during successful pregnancy
    G W Wood
    Department of Pathology, University of Kansas Medical Center, Kansas City 66160 7410, USA
    Mol Reprod Dev 46:62-9; discussion 69-70. 1997
  8. doi Role of the chemokines CCL3/MIP-1 alpha and CCL5/RANTES in sponge-induced inflammatory angiogenesis in mice
    Luciola S Barcelos
    Department of Fisiologia e Biofísica, ICB, UFMG, Belo Horizonte, Brazil
    Microvasc Res 78:148-54. 2009
  9. ncbi Chemokine expression during the development and resolution of a pulmonary leukocyte response to influenza A virus infection in mice
    Mark D Wareing
    La Jolla Institute for Allergy and Immunology, San Diego, CA, USA
    J Leukoc Biol 76:886-95. 2004
  10. pmc Monocyte chemoattractant protein 1, macrophage inflammatory protein 1 alpha, and RANTES recruit macrophages to the kidney in a mouse model of hemolytic-uremic syndrome
    Tiffany R Keepers
    Division of Nephrology, University of Virginia, Box 800133, 1 Lane Road OMS 5815, Charlottesville, VA 22903, USA
    Infect Immun 75:1229-36. 2007

Scientific Experts

  • Koh Hei Sonoda
  • Huiyun Zhang
  • Claire Arnaud
  • Stephan Segerer
  • Adriana C Dos Santos
  • Senthilkumar K Sakthivel
  • Maureen N Ajuebor
  • Adam Szczuciński
  • Michel Cohen-Tannoudji
  • A R Głabiński
  • Tomoya Katakai
  • C Teuscher
  • Christian Weber
  • Antoine Marcais
  • Jianguo Liu
  • Gerhard C Hildebrandt
  • Bo Hu
  • Till Strowig
  • Stephanie C Eisenbarth
  • Chengcheng Jin
  • Richard A Flavell
  • Eran Elinav
  • Liming Hao
  • Jorge Henao-Mejia
  • Meghan J Chenoweth
  • Yuko Ishida
  • Jiin Tarng Liou
  • Dong Seok Kim
  • Jeonghyun Ahn
  • Silvia Di Prisco
  • Fumihiro Tsuzurahara
  • Sajjad Muhammad
  • Alison Crawford
  • Nicole L Sullivan
  • Russell W Jenkins
  • Birgitte Forst
  • Jason C Kovacic
  • Marie Luise Berres
  • Yolanda C Nesbeth
  • Theodore M Danoff
  • Julie Berube
  • Márcia Carvalho Vilela
  • Luciola S Barcelos
  • Martti Laan
  • Valeria de Mello Coelho
  • Alexandre Demoule
  • Satoshi Terao
  • Mevan M Jayasinghe
  • Nazira El-Hage
  • Yasuhiko Makino
  • Ye Zhang
  • Suk Jo Kang
  • Yi Luo
  • Rory R Koenen
  • Thomas E Lane
  • Dennis D Taub
  • Nahum Sonenberg
  • Mitchell H Grayson
  • Regina Krohn
  • Alan M Krensky
  • Carol Clayberger
  • Sung W Choi
  • Tiffany R Keepers
  • Mauro Martins Teixeira
  • Thierry Walzer
  • Jacqueline Marvel
  • Kenneth R Cooke
  • Chen Liu
  • Ravichandran Palaniappan
  • Susanne Herold
  • Charles Antoine Coupet
  • Alma Zernecke
  • Yukoh Nakazaki
  • Krystyna M Olkiewicz
  • Michael J Holtzman
  • Gabriela d'Empaire
  • Fiona J Culley
  • Martine Tomkowiak
  • Robert A Kurt
  • Xiaojing Ma
  • Sebastian F Mause
  • Mohd W Nasser
  • Jeffrey W Tyner
  • Shozo Yano
  • Daisuke Tsuji
  • Peter J Nelson
  • William A Kuziel
  • Mark D Wareing
  • Anne Vroon
  • Traci L Ness

Detail Information

Publications86

  1. ncbi Inducible lung-specific expression of RANTES: preferential recruitment of neutrophils
    Z Z Pan
    Pulmonary and Critical Care Section, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Am J Physiol Lung Cell Mol Physiol 279:L658-66. 2000
    The chemokine regulated on activation normal T cells expressed and secreted (RANTES) has been implicated in eosinophil chemotaxis in asthma and allergic diseases, which are thought to be T helper (Th) type 2-dominated diseases...
  2. ncbi Role of RANTES in the development of autoimmune tissue injuries in MRL-Fas lpr mice
    Tsunemichi Tsukahara
    Department of Medicine and Clinical Oncology, Chiba University Graduate School of Medicine, Chiba, Japan
    Clin Immunol 103:89-97. 2002
    ..To investigate the possible role of RANTES in autoimmune tissue injuries, we have constructed RANTES-deficient MRL-Fas lpr mice by gene targeting...
  3. ncbi GM-CSF DNA induces specific patterns of cytokines and chemokines in the skin: implications for DNA vaccines
    Miguel Angel Perales
    The Swim Across America Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Cytokines Cell Mol Ther 7:125-33. 2002
    ..The early response was characterized by high levels of inflammatory molecules, including IL-1beta, IL-6, TNFalpha, RANTES, MIP-1alpha and MCP-1, later followed by expression of precursor Th1 cytokines, IL-12 and IL-18, concomitant with ..
  4. pmc Involvement of the chemokine RANTES (CCL5) in resistance to experimental infection with Leishmania major
    Helton da Costa Santiago
    Departamento de Bioquimica e Imunologia, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Brazil
    Infect Immun 72:4918-23. 2004
    The expression and putative role of chemokines during infection with Leishmania major in mice were investigated. CCL5 expression correlates with resistance, and blockade of CCL5 rendered mice more susceptible to infection...
  5. pmc The K1 serotype capsular polysaccharide of Porphyromonas gingivalis elicits chemokine production from murine macrophages that facilitates cell migration
    Gabriela d'Empaire
    Department of Oral Biology and Periodontology, Goldman School of Dental Medicine, Boston University Medical Center, MA 02118, USA
    Infect Immun 74:6236-43. 2006
    ..We also defined JE/MCP-1, KC, MIP-2, and RANTES production in response to the P. gingivalis CPS antigens...
  6. ncbi Y-box binding protein-1 controls CC chemokine ligand-5 (CCL5) expression in smooth muscle cells and contributes to neointima formation in atherosclerosis-prone mice
    Regina Krohn
    Institute for Molecular Cardiovascular Research, University Hospital Aachen, RWTH Aachen University, Aachen, Germany
    Circulation 116:1812-20. 2007
    The CC chemokine CCL5/Regulated on Activation, Normal T Cell Expressed and Secreted (RANTES) is upregulated in mononuclear cells or deposited by activated platelets during inflammation and has been implicated in atherosclerosis and ..
  7. ncbi Relative role of CSF-1, MCP-1/JE, and RANTES in macrophage recruitment during successful pregnancy
    G W Wood
    Department of Pathology, University of Kansas Medical Center, Kansas City 66160 7410, USA
    Mol Reprod Dev 46:62-9; discussion 69-70. 1997
    ..macrophages may be recruited from the bone marrow pool through expression of other type 1 chemokines such as JE, RANTES, MIP-1 alpha, MIP-1 beta, IP-10, and KC...
  8. doi Role of the chemokines CCL3/MIP-1 alpha and CCL5/RANTES in sponge-induced inflammatory angiogenesis in mice
    Luciola S Barcelos
    Department of Fisiologia e Biofísica, ICB, UFMG, Belo Horizonte, Brazil
    Microvasc Res 78:148-54. 2009
    We examined the potential contribution of CCL3 and CCL5 to inflammatory angiogenesis in mice.
  9. ncbi Chemokine expression during the development and resolution of a pulmonary leukocyte response to influenza A virus infection in mice
    Mark D Wareing
    La Jolla Institute for Allergy and Immunology, San Diego, CA, USA
    J Leukoc Biol 76:886-95. 2004
    ..protein 1alpha (MIP-1alpha), MIP-1beta, MIP-3alpha, regulated on activation, normal T expressed and secreted (RANTES), MIP-2, and interferon-inducible protein 10 (IP-10) mRNA expression was up-regulated between days 5 and 15 after ..
  10. pmc Monocyte chemoattractant protein 1, macrophage inflammatory protein 1 alpha, and RANTES recruit macrophages to the kidney in a mouse model of hemolytic-uremic syndrome
    Tiffany R Keepers
    Division of Nephrology, University of Virginia, Box 800133, 1 Lane Road OMS 5815, Charlottesville, VA 22903, USA
    Infect Immun 75:1229-36. 2007
    ..monocyte chemoattractant protein 1 (MCP-1/CCL2), macrophage inflammatory protein 1alpha (MIP-1alpha/CCL3), and RANTES (CCL5), in a pattern that was coincident with macrophage infiltration as indicated by immunohistochemistry, ..
  11. pmc CCL5/RANTES gene deletion attenuates opioid-induced increases in glial CCL2/MCP-1 immunoreactivity and activation in HIV-1 Tat-exposed mice
    Nazira El-Hage
    Department of Pharmacology and Toxicology, Virginia Commonwealth University School of Medicine, 1217 East Marshall Street, Richmond, VA 23298 0613, USA
    J Neuroimmune Pharmacol 3:275-85. 2008
    To assess the role of CC-chemokine ligand 5 (CCL5)/RANTES in opiate drug abuse and human immunodeficiency virus type 1 (HIV-1) comorbidity, the effects of systemic morphine and intrastriatal HIV-1 Tat on macrophage/microglial and ..
  12. ncbi Specific induction of macrophage inflammatory protein 1-alpha in glial cells of Sandhoff disease model mice associated with accumulation of N-acetylhexosaminyl glycoconjugates
    Daisuke Tsuji
    Department of Medicinal Biotechnology, Institute of Medicinal Resources, Graduate School of Pharmaceutical Sciences, The University of Tokushima, 1 78 Sho machi, Tokushima 770 8505, Japan
    J Neurochem 92:1497-507. 2005
    ..On the other hand, little changes in other chemokine mRNAs, including those of RANTES (regulated upon activation, normal T expressed and secreted), MCP-1 (monocyte chemotactic protein-1), SLC (..
  13. ncbi Interferon regulatory factor 1 is an essential and direct transcriptional activator for interferon {gamma}-induced RANTES/CCl5 expression in macrophages
    Jianguo Liu
    Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Biol Chem 280:24347-55. 2005
    ..b>RANTES (regulated on activation normal T cell expressed and secreted; CCL5) is a member of the CC chemokine family of ..
  14. ncbi Role of MCP-1 and RANTES in inflammation and progression to fibrosis during murine crescentic nephritis
    C M Lloyd
    Department of Medicine, Boston University Medical Center, Massachusetts, USA
    J Leukoc Biol 62:676-80. 1997
    ..We have investigated the functional role that the chemokines monocyte chemotactic protein-1 (MCP-1) and RANTES play in inflammation and the progression to fibrosis during crescentic nephritis...
  15. pmc Chemokine gene expression in the brains of mice with lymphocytic choriomeningitis
    V C Asensio
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Virol 71:7832-40. 1997
    ..from the greatest to the least): cytokine responsive gene-2 or interferon-inducible 10-kDa protein (Crg-2/IP-10), RANTES, monocyte chemotactic protein-1 (MCP-1), macrophage inflammatory protein-1 (MIP-1beta), and MCP-3...
  16. ncbi Controls for lung dendritic cell maturation and migration during respiratory viral infection
    Mitchell H Grayson
    Division of Allergy and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 179:1438-48. 2007
    ..Maturation and migration of lung cDCs depends on Ccl5 and Ccr5 signals because these events are significantly impaired in Ccl5(-/-) and Ccr5(-/-) mice...
  17. ncbi Interferon regulatory factor 8 regulates RANTES gene transcription in cooperation with interferon regulatory factor-1, NF-kappaB, and PU.1
    Jianguo Liu
    Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Biol Chem 281:19188-95. 2006
    ..Regulated on activation, normal T cell expressed and secreted (RANTES, or CCL5) is a member of the CC chemokine family of proteins, strongly chemoattractant for several important ..
  18. ncbi CCL5 modulates pneumococcal immunity and carriage
    Ravichandran Palaniappan
    Mercer University, Atlanta, GA 30341, USA
    J Immunol 176:2346-56. 2006
    ..Recently, it has been shown that genetic polymorphisms can result in diminished expression of CCL5, which results in increased susceptibility to and progression of infectious diseases...
  19. ncbi Sequence polymorphisms in the chemokines Scya1 (TCA-3), Scya2 (monocyte chemoattractant protein (MCP)-1), and Scya12 (MCP-5) are candidates for eae7, a locus controlling susceptibility to monophasic remitting/nonrelapsing experimental allergic encephalomy
    C Teuscher
    Department of Veterinary Pathobiology, University of Illinois at Urbana Champaign 61802, USA
    J Immunol 163:2262-6. 1999
    ..Similarly, cDNA sequence polymorphisms in Nos2, Scya3, Scya4, Scya5, Scya6, Scya7, Scya9, Scya10, and Scya11 were excluded as candidates for eae7...
  20. ncbi Antibody targeting of the CC chemokine ligand 5 results in diminished leukocyte infiltration into the central nervous system and reduced neurologic disease in a viral model of multiple sclerosis
    William G Glass
    Center for Immunology and Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697, USA
    J Immunol 172:4018-25. 2004
    ..In this study, we administer a mAb directed against CCL5 to mice with established mouse hepatitis virus-induced demyelination and impaired motor skills...
  21. ncbi Impaired T cell function in RANTES-deficient mice
    Yasuhiko Makino
    Penn Center for Molecular Studies of Kidney Disease, Renal Electrolyte and Hypertension Division, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Clin Immunol 102:302-9. 2002
    The chemokine RANTES is a chemoattractant for monocytes and T cells and is postulated to participate in many aspects of the immune response...
  22. pmc MIP-1alpha, MIP-1beta, RANTES, and ATAC/lymphotactin function together with IFN-gamma as type 1 cytokines
    Brigitte G Dorner
    Molecular Immunology, Robert Koch Institute, D 13353 Berlin, Germany
    Proc Natl Acad Sci U S A 99:6181-6. 2002
    ..inflammatory protein (MIP)-1alpha, MIP-1beta, regulated on activation normal T cell expressed and secreted (RANTES), and activation-induced, T cell-derived, and chemokine-related cytokine (ATAC)/lymphotactin are cosecreted to a ..
  23. ncbi CCL5-CCR5 interaction provides antiapoptotic signals for macrophage survival during viral infection
    Jeffrey W Tyner
    Department of Medicine, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    Nat Med 11:1180-7. 2005
    ..Here we identify one such mechanism. We show that mice lacking the chemokine Ccl5 are immune compromised to the point of delayed viral clearance, excessive airway inflammation and respiratory death ..
  24. ncbi CCR1 and CC chemokine ligand 5 interactions exacerbate innate immune responses during sepsis
    Traci L Ness
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Immunol 173:6938-48. 2004
    ..CCR1 and CCL5 interactions markedly altered the inflammatory response in vivo and in vitro...
  25. pmc A translational rheostat for RFLAT-1 regulates RANTES expression in T lymphocytes
    Tania Nikolcheva
    Department of Pediatrics, Stanford University School of Medicine, 300 Pasteur Drive, CCSR 2105, Stanford, CA 94305 5164, USA
    J Clin Invest 110:119-26. 2002
    ..begins late after T cell activation and involves expression of effector genes, including the chemokine RANTES and its major transcriptional regulator, RANTES factor of late-activated T lymphocytes-1 (RFLAT-1)...
  26. doi IL-15 can signal via IL-15Rα, JNK, and NF-κB to drive RANTES production by myeloid cells
    Meghan J Chenoweth
    Department of Pathology and Molecular Medicine, McMaster Immunology Research Centre and Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario L8S 4K1, Canada
    J Immunol 188:4149-57. 2012
    ..Furthermore, treatment with IL-15 induced RANTES production by Rag2(-/-)γ(c)(-/-) bone marrow cells, but the presence of γ(c) did not increase bone marrow cell ..
  27. pmc STING manifests self DNA-dependent inflammatory disease
    Jeonghyun Ahn
    Department of Cell Biology and Sylvester Comprehensive Cancer Center, University of Miami School of Medicine, Miami, FL 33136, USA
    Proc Natl Acad Sci U S A 109:19386-91. 2012
    ..Our data provides significant molecular insight into the causes of DNA-mediated inflammatory disorders and affords a target that could plausibly be therapeutically controlled to help prevent such diseases...
  28. pmc Importance of the CCR5-CCL5 axis for mucosal Trypanosoma cruzi protection and B cell activation
    Nicole L Sullivan
    Department of Molecular Microbiology and Immunology, Saint Louis University Medical Center, St Louis, MO 63104, USA
    J Immunol 187:1358-68. 2011
    ..cruzi protection. We evaluated the importance of CCR5 and CCL5 for mucosal protection against natural oral and conjunctival T. cruzi challenges. T...
  29. pmc Fbw7γ-mediated degradation of KLF13 prevents RANTES expression in resting human but not murine T lymphocytes
    Dong Seok Kim
    Laboratory of Cellular and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 120:1658-67. 2012
    b>RANTES (CCL5) is a chemokine implicated in many human diseases...
  30. doi Absence of C-C motif chemokine ligand 5 in mice leads to decreased local macrophage recruitment and behavioral hypersensitivity in a murine neuropathic pain model
    Jiin Tarng Liou
    Department of Anesthesiology, Chang Gung Memorial Hospital, Linkou, Taiwan, ROC
    Pain 153:1283-91. 2012
    Accumulated evidence suggests that the C-C motif chemokine ligand 5 (CCL5) modulates migration of inflammatory cells in several pathological conditions...
  31. pmc Pivotal role of the CCL5/CCR5 interaction for recruitment of endothelial progenitor cells in mouse wound healing
    Yuko Ishida
    Department of Forensic Medicine, Institute of Advanced Medicine, Wakayama Medical University, Wakayama, Japan
    J Clin Invest 122:711-21. 2012
    ..Consistent with these observations, CCL5 induced in vitro EPC migration in a CCR5-dependent manner...
  32. pmc Microbiota-induced activation of epithelial IL-6 signaling links inflammasome-driven inflammation with transmissible cancer
    Bo Hu
    Departments of Immunobiology, Laboratory Medicine, and Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 110:9862-7. 2013
    ..Enhanced tumorigenesis is dependent on microbiota-induced chemokine (C-C motif) ligand 5 (CCL5)-driven inflammation, which in turn promotes epithelial cell proliferation through local activation of the IL-6 ..
  33. pmc Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity
    Jorge Henao-Mejia
    Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Nature 482:179-85. 2012
    ....
  34. doi RANTES-mediated control of excitatory amino acid release in mouse spinal cord
    Silvia Di Prisco
    Department of Experimental Medicine, Pharmacology and Toxicology Section, University of Genoa, Genoa, Italy
    J Neurochem 121:428-37. 2012
    The impact of Regulated upon Activation Normal T cells Expressed and Secreted (RANTES) on the release of pre-loaded [³H]D-aspartate ([³H]D-ASP) from mouse spinal cord synaptosomes was investigated. RANTES (0...
  35. pmc CCL5 regulation of mucosal chlamydial immunity and infection
    Senthilkumar K Sakthivel
    Emory University School of Medicine, Department of Pathology, Atlanta GA, USA
    BMC Microbiol 8:136. 2008
    ..We have shown that CCR5, a receptor for CCL5, is crucial for protective chlamydial immunity...
  36. pmc Blood cell-derived RANTES mediates cerebral microvascular dysfunction, inflammation, and tissue injury after focal ischemia-reperfusion
    Satoshi Terao
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130, USA
    Stroke 39:2560-70. 2008
    ..This study tested the hypothesis that RANTES (CCL5; regulated on activation, normal T-cell expressed and secreted) mediates the cerebral microvascular ..
  37. pmc CD4+ T cells elicit host immune responses to MHC class II-negative ovarian cancer through CCL5 secretion and CD40-mediated licensing of dendritic cells
    Yolanda C Nesbeth
    Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, NH 03756, USA
    J Immunol 184:5654-62. 2010
    ..mechanism whereby tumor-primed CD4(+) T cells transferred into ovarian cancer-bearing mice secrete high levels of CCL5, which recruits endogenous CCR5(+) dendritic cells to tumor locations and activate them through CD40-CD40L ..
  38. ncbi Tumor-derived CCL5 does not contribute to breast cancer progression
    Mevan M Jayasinghe
    Department Biology, Lafayette College, Easton, PA 18042, USA
    Breast Cancer Res Treat 111:511-21. 2008
    Besides functioning as a chemotactic factor, CCL5 has been associated with progression of disease in women with breast cancer, immune modulation and metastasis...
  39. pmc CCR1/CCL5 (RANTES) receptor-ligand interactions modulate allogeneic T-cell responses and graft-versus-host disease following stem-cell transplantation
    Sung W Choi
    Department of Pediatrics, Blood and Marrow Transplantation Program, University of Michigan, Ann Arbor, MI, USA
    Blood 110:3447-55. 2007
    ..T-cell function was partially dependent on interactions between CCR1 and CCL5. Collectively, these data demonstrate that CCR1 expression on donor cells contributes to the development of both ..
  40. pmc A role for the chemokine RANTES in regulating CD8 T cell responses during chronic viral infection
    Alison Crawford
    Department of Microbiology and Institute for Immunology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
    PLoS Pathog 7:e1002098. 2011
    b>RANTES (CCL5) is a chemokine expressed by many hematopoietic and non-hematopoietic cell types that plays an important role in homing and migration of effector and memory T cells during acute infections...
  41. pmc Kinin B2 receptor regulates chemokines CCL2 and CCL5 expression and modulates leukocyte recruitment and pathology in experimental autoimmune encephalomyelitis (EAE) in mice
    Adriana C Dos Santos
    Department of Physiology and Biophysics, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil
    J Neuroinflammation 5:49. 2008
    ..We have previously shown that the chemokines CCL2 and CCL5 play an important role in the adhesion of leukocytes to the brain microcirculation in EAE...
  42. pmc Regulation of hierarchical clustering and activation of innate immune cells by dendritic cells
    Suk Jo Kang
    Howard Hughes Medical Institute, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143 0795, USA
    Immunity 29:819-33. 2008
    ..Thus, spatial organization of the immune response by DCs between 6 and 24 hr ensures functional activation of innate cells, which restricts pathogens before adaptive immunity is fully activated...
  43. pmc Metastasis-inducing S100A4 and RANTES cooperate in promoting tumor progression in mice
    Birgitte Forst
    Department for Molecular Cancer Biology, Danish Cancer Society, Copenhagen, Denmark
    PLoS ONE 5:e10374. 2010
    ..However, the events implicated in upstream and downstream pathways regulating the activity of the extracellular S100A4 protein in the tumor milieu remain unsolved...
  44. pmc Fat-storing multilocular cells expressing CCR5 increase in the thymus with advancing age: potential role for CCR5 ligands on the differentiation and migration of preadipocytes
    Valeria de Mello Coelho
    Laboratories of Immunology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Int J Med Sci 7:1-14. 2009
    ..We verified that the expression of CCR5 and its ligands, CCL3, CCL4 and CCL5, were increased in the thymus with age...
  45. pmc Stat3-dependent acute Rantes production in vascular smooth muscle cells modulates inflammation following arterial injury in mice
    Jason C Kovacic
    Translational Medicine Branch, National Heart, Lung, and Blood Institute NIH, Bethesda, MD 20892, USA
    J Clin Invest 120:303-14. 2010
    ..studied these events in mice and found that immediately following arterial injury, medial VSMCs upregulated Rantes in an acute manner dependent on Stat3 and NF-kappaB (p65 subunit)...
  46. pmc V(alpha)14iNKT cells promote liver pathology during adenovirus infection by inducing CCL5 production: implications for gene therapy
    Maureen N Ajuebor
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center Shreveport, Shreveport, Louisiana 71130, USA
    J Virol 84:8520-9. 2010
    ..in response to adenovirus infection to induce significant levels of hepatic chemokine (C-C motif) ligand 5 (CCL5) and subsequent liver toxicity...
  47. pmc Autoimmune regulator deficiency results in decreased expression of CCR4 and CCR7 ligands and in delayed migration of CD4+ thymocytes
    Martti Laan
    Molecular Pathology Group, Institute of General and Molecular Pathology, Tartu University, Tartu, Estonia
    J Immunol 183:7682-91. 2009
    ..These results suggest a novel mechanism behind the Aire-dependent induction of central tolerance...
  48. pmc Antagonism of the chemokine Ccl5 ameliorates experimental liver fibrosis in mice
    Marie Luise Berres
    Medical Department III, University Hospital Aachen, Aachen, Germany
    J Clin Invest 120:4129-40. 2010
    ..Herein, we identify the chemokine CCL5 (also known as RANTES), which is induced in murine and human liver after injury, as a central mediator of this interaction...
  49. pmc Chemokine receptor and ligand upregulation in the diaphragm during endotoxemia and Pseudomonas lung infection
    Alexandre Demoule
    Meakins Christie Laboratories, McGill University, Montreal, QC, Canada H2X 2P2
    Mediators Inflamm 2009:860565. 2009
    ..and molecular regulation of the chemokines, regulated upon activation normal T cell expressed and secreted (RANTES) and macrophage inflammatory protein (MIP)-1alpha, in the murine diaphragm during sepsis...
  50. doi The chemokine CCL5 is essential for leukocyte recruitment in a model of severe Herpes simplex encephalitis
    Márcia Carvalho Vilela
    Departamento de Clinica Medica, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
    Ann N Y Acad Sci 1153:256-63. 2009
    ..Met-RANTES (regulated upon activation, normal T cell expressed and presumably secreted) (10 microg/mouse), a CC chemokine ..
  51. doi Distinct intracellular signaling pathways control the synthesis of IL-8 and RANTES in TLR1/TLR2, TLR3 or NOD1 activated human airway epithelial cells
    Julie Berube
    Meakins Christie Laboratories, McGill University Heath Centre Research Institute, 3626 St Urbain, Montreal, Canada H2X 2P2
    Cell Signal 21:448-56. 2009
    ..capacity to up-regulate Interleukin-8 (IL-8) and Regulated upon Activation Normal T cell Expressed and Secreted (RANTES) in airway epithelial cells...
  52. doi Influenza virus infection aggravates stroke outcome
    Sajjad Muhammad
    Department of Pharmacology, University of Heidelberg, Im Neuenheimer Feld 366, 69120 Heidelberg, Germany
    Stroke 42:783-91. 2011
    ..Stroke is triggered by several risk factors, including influenza and other respiratory tract infections. However, it is unknown how and in which way influenza infection affects stroke outcome...
  53. pmc Regulation of CC ligand 5/RANTES by acid sphingomyelinase and acid ceramidase
    Russell W Jenkins
    Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Biol Chem 286:13292-303. 2011
    ..In the present study using a chemokine/cytokine screen, we identified the chemokine CCL5 (formerly known as RANTES) as a candidate-specific downstream target for aSMase...
  54. doi The basic residue cluster (55)KKWVR(59) in CCL5 is required for in vivo biologic function
    Stephan Segerer
    University Hospital Zurich, Switzerland
    Mol Immunol 46:2533-8. 2009
    ..b>CCL5 contains two clusters of basic amino acid residues ((44)RKNR(47) and (55)KKWVR(59)) implicated in presentation of ..
  55. ncbi Cell-autonomous CCL5 transcription by memory CD8 T cells is regulated by IL-4
    Antoine Marcais
    Institut National de la Sante de la Recherche Medicale, Unité 503, 21 Avenue Tony Garnier, Lyon, France
    J Immunol 177:4451-7. 2006
    ..The maintenance by CD8 memory cells of high levels of untranslated CCL5 mRNA allows these cells to immediately secrete this chemokine upon Ag stimulation...
  56. ncbi NKT cell-derived RANTES recruits APCs and CD8+ T cells to the spleen during the generation of regulatory T cells in tolerance
    Douglas E Faunce
    Schepens Eye Research Institute, Harvard Medical School, Boston, MA 02114, USA
    J Immunol 169:31-8. 2002
    ..by either CD1d-transfected fibroblasts in vitro or CD1d(+) tolerogenic APCs both in vivo and ex vivo produced RANTES in a CD1d-dependent manner...
  57. ncbi Immunoregulatory role of ocular macrophages: the macrophages produce RANTES to suppress experimental autoimmune uveitis
    Koh Hei Sonoda
    Department of Ophthalmology, Graduate School of Medical Science, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Immunol 171:2652-9. 2003
    ..We found that only the macrophage-enriched cells from the eye produced RANTES, and thus proposed that macrophage-derived RANTES facilitated the ocular inflammations...
  58. ncbi RANTES stimulates inflammatory cascades and receptor modulation in murine astrocytes
    Yi Luo
    Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Glia 39:19-30. 2002
    Cultured mouse astrocytes respond to the CC chemokine RANTES by production of chemokine and cytokine transcripts...
  59. ncbi Expression of chemokines RANTES, MIP-1alpha and GRO-alpha correlates with inflammation in acute experimental autoimmune encephalomyelitis
    A R Glabinski
    Department of Neurosciences, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Neuroimmunomodulation 5:166-71. 1998
    ..In the present study we analyzed the gene expression of three chemokines, RANTES, MIP-1alpha and GRO-alpha, at the onset of acute EAE, and correlated that expression with the intensity of ..
  60. ncbi Isolation and characterization of cDNA from renal tubular epithelium encoding murine Rantes
    P Heeger
    Department of Medicine, University of Pennsylvania, Philadelphia
    Kidney Int 41:220-5. 1992
    ..In this report we have isolated cDNA encoding murine Rantes (MuRantes) from renal tubular epithelium (MCT cells)...
  61. ncbi A 2-Mb YAC/BAC-based physical map of the ovum mutant (Om) locus region on mouse chromosome 11
    M Cohen-Tannoudji
    Unite de Biologie du Developpement, CNRS URA 1960, Institut Pasteur, 25 rue du Dr Roux, Paris Cedex 15, 75724, France
    Genomics 68:273-82. 2000
    ..Two other genes (Rad51l3 and Schlafen 2) and one EST (D11Wsu78e) were also mapped in the Om region. This integrated map provides support for the identification of additional candidate genes for the DDK syndrome...
  62. ncbi RANTES-mediated chemokine transcription in astrocytes involves activation and translocation of p90 ribosomal S6 protein kinase (RSK)
    Ye Zhang
    Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 277:19042-8. 2002
    b>RANTES (regulated on activation normal T cell expressed and secreted) (> or =10 ng/ml) stimulates the induction of KC and other chemokines in astrocytes...
  63. ncbi RANTES-induced chemokine cascade in dendritic cells
    F R Fischer
    Department of Pathology, Harvard Medical School, Dana Farber Cancer Institute, 200 Longwood Avenue, Boston, MA 02115, USA
    J Immunol 167:1637-43. 2001
    ..Murine bone marrow-derived DC respond to the CC chemokine RANTES (10-100 ng/ml) by production of proinflammatory mediators...
  64. ncbi A dual role for tumor-derived chemokine RANTES (CCL5)
    Evan P Adler
    Department of Biology, Lafayette College, Easton, PA 18042, USA
    Immunol Lett 90:187-94. 2003
    To investigate the role of tumor-derived CCL5 (regulated upon activation, normal T cell expressed and secreted, RANTES) in tumor immunity we compared the T cell response to tumors derived from the 4T1 murine mammary carcinoma cell line ..
  65. ncbi Reduced GRK2 level in T cells potentiates chemotaxis and signaling in response to CCL4
    Anne Vroon
    Laboratory for Psychoneuroimmunology, University Medical Center Utrecht, The Netherlands
    J Leukoc Biol 75:901-9. 2004
    ..whether reduced GRK2 expression changes the chemotactic response of T cells to the chemokines CCL3, CCL4, and CCL5. Activated T cells from GRK2+/- mice, which have a 50% reduction in GRK2 protein levels, showed a significant 40% ..
  66. pmc Lymph node fibroblastic reticular cells construct the stromal reticulum via contact with lymphocytes
    Tomoya Katakai
    Center for Molecular Biology and Genetics, Kyoto University, 53 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    J Exp Med 200:783-95. 2004
    ..These findings suggest that signals from lymphocytes induce FRCs to form the network that supports the movement and interactions of immune effectors within the lymph node...
  67. ncbi Cloning, genomic organization, and chromosomal localization of the Scya5 gene encoding the murine chemokine RANTES
    T M Danoff
    Penn Center for Molecular Studies of Kidney Diseases, University of Pennsylvania, Philadelphia 19104
    J Immunol 152:1182-9. 1994
    ..regulation of RANTES, we have determined the genomic organization of the gene encoding the small inducible cytokine A5 (Scya5) and performed an initial analysis of its promoter elements...
  68. ncbi Role of macrophages and colony-stimulating factor-1 in murine antiglomerular basement membrane glomerulonephritis
    J Neugarten
    Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Am Soc Nephrol 5:1903-9. 1995
    ..macrophage-related cytokines, colony stimulating factor-1 (CSF-1), monocyte chemoattractant protein-1 (MCP-1) and RANTES, accelerated anti-GBM nephritis was studied in op/op mutant mice, which lack CSF-1 and are severely macrophage ..
  69. ncbi Serial analysis of gene expression in progressing and regressing mouse tumors implicates the involvement of RANTES and TARC in antitumor immune responses
    Yukoh Nakazaki
    Division of Molecular and Clinical Genetics, Medical Institute of Bioregulation, Kyushu University Hospital, Kyushu University, Fukuoka 812 8582, Japan
    Mol Ther 14:599-606. 2006
    ..Focusing on the chemokine genes TARC and RANTES, which were preferentially expressed in the GM-CSF-transduced tumors, their forced expression on mouse tumor cells ..
  70. ncbi Cross-desensitization among CXCR1, CXCR2, and CCR5: role of protein kinase C-epsilon
    Mohd W Nasser
    Julius L Chambers Biomedical Biotechnology Research Institute, North Carolina Central University, Durham, 27707, USA
    J Immunol 174:6927-33. 2005
    ..Because DeltaCXCR2, but not CXCR2, activates PKCepsilon and cross-desensitizes CCR5, the data further suggest that signal duration leading to activation of novel PKC may modulate receptor-mediated cross-inhibitory signals...
  71. ncbi Platelet microparticles: a transcellular delivery system for RANTES promoting monocyte recruitment on endothelium
    Sebastian F Mause
    Department of Molecular Cardiovascular Research, University Hospital, Aachen, Germany
    Arterioscler Thromb Vasc Biol 25:1512-8. 2005
    Platelet activation mediates multiple cellular responses, including secretion of chemokines such as RANTES (CCL5), and formation of platelet microparticles (PMPs)...
  72. ncbi Functional expression of beta-chemokine receptors in osteoblasts: role of regulated upon activation, normal T cell expressed and secreted (RANTES) in osteoblasts and regulation of its secretion by osteoblasts and osteoclasts
    Shozo Yano
    Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine and Membrane Biology Program, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Endocrinology 146:2324-35. 2005
    ..functions of receptors for the beta-chemokine, regulated upon activation, normal T cell expressed, and secreted (RANTES)/CCL5, were investigated in osteoblasts...
  73. ncbi Donor T-cell production of RANTES significantly contributes to the development of idiopathic pneumonia syndrome after allogeneic stem cell transplantation
    Gerhard C Hildebrandt
    Department of Pediatrics, Blood and Marrow Transplantation Program, University of Michigan, Ann Arbor, MI, USA
    Blood 105:2249-57. 2005
    ..b>RANTES is a chemokine ligand that is up-regulated during inflammation and promotes the recruitment of T cells and ..
  74. ncbi The role of CC chemokine receptor 5 (CCR5) and RANTES/CCL5 during chronic fungal asthma in mice
    Jane M Schuh
    Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    FASEB J 16:228-30. 2002
    ..Immunoneutralization of RANTES/CCL5 in sensitized CCR5+/+ and CCR5-/- mice for 12 days after the conidia challenge significantly reduced the ..
  75. ncbi Molecular cloning and functional characterization of a novel member of the C-C chemokine family
    T Hara
    DNAX Research Institute of Molecular and Cellular Biology, Palo Alto 94304, USA
    J Immunol 155:5352-8. 1995
    ..These results clearly indicate that CCF18 is a new member of the C-C chemokine family. Since a high level of CCF18 mRNA is constitutively expressed in macrophage and myeloid cell lines, CCF18 may play a role in inflammatory processes...
  76. ncbi Molecular characterization of two murine eosinophil beta chemokine receptors
    T W Post
    Department of Medicine, Brigham and Women s Hospital, Beth Israel Hospital, Boston, MA, USA
    J Immunol 155:5299-305. 1995
    beta or C-C chemokines including RANTES, MCP-3, MIP-1 alpha, and eotaxin have been implicated in the pathogenesis of eosinophilic inflammation...
  77. ncbi Molecular cloning and expression of the murine RANTES cytokine: structural and functional conservation between mouse and man
    T J Schall
    Department of Immunology, Genentech, South San Francisco, CA 94080
    Eur J Immunol 22:1477-81. 1992
    ..We report here on the molecular cloning, characterization, and functional expression of mu RANTES, a new murine member of this family...
  78. pmc Role of CCL5 (RANTES) in viral lung disease
    Fiona J Culley
    Department of Respiratory Medicine, National Heart and Lung Institute, Imperial College London, St Mary s Campus, Norfolk Place, London W2 1PG, United Kingdom
    J Virol 80:8151-7. 2006
    CCL5/RANTES is a key proinflammatory chemokine produced by virus-infected epithelial cells and present in respiratory secretions of asthmatics...
  79. ncbi Characterization of lipopolysaccharide responsive proteins that binds to the 5'-flanking regions of mouse Rantes
    Youn Uck Kim
    Division of Applied Biological Sciences, SunMoon University, Asan, Korea
    Mol Cells 13:91-8. 2002
    ..with lipopolysaccharide (LPS), factors that bind specifically to the LPS responsive element (LRE) of murine Rantes gene appeared in the nucleus...
  80. ncbi Alveolar epithelial cells direct monocyte transepithelial migration upon influenza virus infection: impact of chemokines and adhesion molecules
    Susanne Herold
    University of Giessen Lung Center, Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine and Infectious Diseases, Justus Liebig University, Giessen, Germany
    J Immunol 177:1817-24. 2006
    ..the mouse-adapted influenza A virus strain PR/8 strongly induced the release of monocyte chemoattractants CCL2 and CCL5 followed by a strong monocyte transepithelial migration, and this monocytic response was strictly dependent on ..
  81. doi The role of macrophages in the disappearance of Meckel's cartilage during mandibular development in mice
    Fumihiro Tsuzurahara
    Department of Oral Anatomy and Developmental Biology, Showa University School of Dentistry, 1 5 8 Hatanodai, Shinagawa ku, Tokyo, Japan
    Acta Histochem 113:194-200. 2011
    ....
  82. ncbi Deposition of platelet RANTES triggering monocyte recruitment requires P-selectin and is involved in neointima formation after arterial injury
    Andreas Schober
    Department of Molecular Cardiovascular Research and Cardiology, Rheinisch Westfälische Technische Hochschule Aachen, Germany
    Circulation 106:1523-9. 2002
    ....
  83. ncbi Hmgi-c-independent Activation of MuRantes in Vivo
    John F Schiltz
    Department of Biochemistry, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    Cell Growth Differ 13:39-45. 2002
    ..from macrophage cell lines has previously suggested that Hmgi-c is necessary for the inducible activation of MuRantes expression...
  84. pmc Heritability of the maternal meiotic drive system linked to Om and high-resolution mapping of the Responder locus in mouse
    F Pardo-Manuel de Villena
    Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    Genetics 155:283-9. 2000
    ..In addition, analysis of the inheritance of alleles at Om among the offspring of F(1) intercrosses indicates that the effect of the sire is determined by the sperm genotype at Om or a locus linked to Om...
  85. ncbi Regulatory context is a crucial part of gene function
    Sabine Fessele
    Medizinische Poliklinik der Ludwig Maximilians Universität München, Schillerstr 42, D 80336, Munich, Germany
    Trends Genet 18:60-3. 2002
    ..Using the human RANTES/CCL5 promoter, we show that organizational features of promoters derived from promoter sequences contain ..
  86. ncbi Maintenance of CCL5 mRNA stores by post-effector and memory CD8 T cells is dependent on transcription and is coupled to increased mRNA stability
    Antoine Marcais
    INSERM, U503, Lyon, France
    Eur J Immunol 36:2745-54. 2006
    ..The storage of untranslated mRNA coding for the CCL5 chemokine by CD8 memory cells is a new process supporting the immediate display of an effector function...