Gene Symbol: Ccl5
Description: chemokine (C-C motif) ligand 5
Alias: MuRantes, RANTES, SISd, Scya5, TCP228, C-C motif chemokine 5, SIS-delta, T-cell-specific protein RANTES, small-inducible cytokine A5
Species: mouse
Products:     Ccl5

Top Publications

  1. Santiago H, Oliveira C, Santiago L, Ferraz F, de Souza D, de Freitas L, et al. Involvement of the chemokine RANTES (CCL5) in resistance to experimental infection with Leishmania major. Infect Immun. 2004;72:4918-23 pubmed
    The expression and putative role of chemokines during infection with Leishmania major in mice were investigated. CCL5 expression correlates with resistance, and blockade of CCL5 rendered mice more susceptible to infection...
  2. Grayson M, Ramos M, Rohlfing M, Kitchens R, Wang H, Gould A, et al. Controls for lung dendritic cell maturation and migration during respiratory viral infection. J Immunol. 2007;179:1438-48 pubmed
    ..Maturation and migration of lung cDCs depends on Ccl5 and Ccr5 signals because these events are significantly impaired in Ccl5(-/-) and Ccr5(-/-) mice...
  3. Sakthivel S, Singh U, Singh S, Taub D, Igietseme J, Lillard J. CCL5 regulation of mucosal chlamydial immunity and infection. BMC Microbiol. 2008;8:136 pubmed publisher
    ..We have shown that CCR5, a receptor for CCL5, is crucial for protective chlamydial immunity...
  4. El Hage N, Bruce Keller A, Knapp P, Hauser K. CCL5/RANTES gene deletion attenuates opioid-induced increases in glial CCL2/MCP-1 immunoreactivity and activation in HIV-1 Tat-exposed mice. J Neuroimmune Pharmacol. 2008;3:275-85 pubmed publisher
    To assess the role of CC-chemokine ligand 5 (CCL5)/RANTES in opiate drug abuse and human immunodeficiency virus type 1 (HIV-1) comorbidity, the effects of systemic morphine and intrastriatal HIV-1 Tat on macrophage/microglial and ..
  5. Zhang Y, Lv D, Kim H, Kurt R, Bu W, Li Y, et al. A novel role of hematopoietic CCL5 in promoting triple-negative mammary tumor progression by regulating generation of myeloid-derived suppressor cells. Cell Res. 2013;23:394-408 pubmed publisher
    b>CCL5 is a member of the CC chemokine family expressed in a wide array of immune and non-immune cells in response to stress signals. CCL5 expression correlates with advanced human breast cancer...
  6. Ness T, Carpenter K, Ewing J, Gerard C, Hogaboam C, Kunkel S. CCR1 and CC chemokine ligand 5 interactions exacerbate innate immune responses during sepsis. J Immunol. 2004;173:6938-48 pubmed
    ..CCR1 and CCL5 interactions markedly altered the inflammatory response in vivo and in vitro...
  7. Dorner B, Scheffold A, Rolph M, Huser M, Kaufmann S, Radbruch A, et al. MIP-1alpha, MIP-1beta, RANTES, and ATAC/lymphotactin function together with IFN-gamma as type 1 cytokines. Proc Natl Acad Sci U S A. 2002;99:6181-6 pubmed
    ..inflammatory protein (MIP)-1alpha, MIP-1beta, regulated on activation normal T cell expressed and secreted (RANTES), and activation-induced, T cell-derived, and chemokine-related cytokine (ATAC)/lymphotactin are cosecreted to a ..
  8. Asensio V, Campbell I. Chemokine gene expression in the brains of mice with lymphocytic choriomeningitis. J Virol. 1997;71:7832-40 pubmed
    ..from the greatest to the least): cytokine responsive gene-2 or interferon-inducible 10-kDa protein (Crg-2/IP-10), RANTES, monocyte chemotactic protein-1 (MCP-1), macrophage inflammatory protein-1 (MIP-1beta), and MCP-3...
  9. Danoff T, Lalley P, Chang Y, Heeger P, Neilson E. Cloning, genomic organization, and chromosomal localization of the Scya5 gene encoding the murine chemokine RANTES. J Immunol. 1994;152:1182-9 pubmed
    ..regulation of RANTES, we have determined the genomic organization of the gene encoding the small inducible cytokine A5 (Scya5) and performed an initial analysis of its promoter elements...

More Information


  1. Elinav E, Strowig T, Kau A, Henao Mejia J, Thaiss C, Booth C, et al. NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis. Cell. 2011;145:745-57 pubmed publisher neonatal or adult wild-type mice, leading to exacerbation of DSS colitis via induction of the cytokine, CCL5. Antibiotic treatment and electron microscopy studies further supported the role of Prevotellaceae as a key ..
  2. Makino Y, Cook D, Smithies O, Hwang O, Neilson E, Turka L, et al. Impaired T cell function in RANTES-deficient mice. Clin Immunol. 2002;102:302-9 pubmed
    The chemokine RANTES is a chemoattractant for monocytes and T cells and is postulated to participate in many aspects of the immune response...
  3. Wareing M, Lyon A, Lu B, Gerard C, Sarawar S. Chemokine expression during the development and resolution of a pulmonary leukocyte response to influenza A virus infection in mice. J Leukoc Biol. 2004;76:886-95 pubmed
    ..protein 1alpha (MIP-1alpha), MIP-1beta, MIP-3alpha, regulated on activation, normal T expressed and secreted (RANTES), MIP-2, and interferon-inducible protein 10 (IP-10) mRNA expression was up-regulated between days 5 and 15 after ..
  4. Palaniappan R, Singh S, Singh U, Singh R, Ades E, Briles D, et al. CCL5 modulates pneumococcal immunity and carriage. J Immunol. 2006;176:2346-56 pubmed
    ..Recently, it has been shown that genetic polymorphisms can result in diminished expression of CCL5, which results in increased susceptibility to and progression of infectious diseases...
  5. Tyner J, Uchida O, Kajiwara N, Kim E, Patel A, O Sullivan M, et al. CCL5-CCR5 interaction provides antiapoptotic signals for macrophage survival during viral infection. Nat Med. 2005;11:1180-7 pubmed
    ..Here we identify one such mechanism. We show that mice lacking the chemokine Ccl5 are immune compromised to the point of delayed viral clearance, excessive airway inflammation and respiratory death ..
  6. Glass W, Hickey M, Hardison J, Liu M, Manning J, Lane T. Antibody targeting of the CC chemokine ligand 5 results in diminished leukocyte infiltration into the central nervous system and reduced neurologic disease in a viral model of multiple sclerosis. J Immunol. 2004;172:4018-25 pubmed
    ..In this study, we administer a mAb directed against CCL5 to mice with established mouse hepatitis virus-induced demyelination and impaired motor skills...
  7. Hildebrandt G, Olkiewicz K, Choi S, Corrion L, Clouthier S, Liu C, et al. Donor T-cell production of RANTES significantly contributes to the development of idiopathic pneumonia syndrome after allogeneic stem cell transplantation. Blood. 2005;105:2249-57 pubmed
    ..b>RANTES is a chemokine ligand that is up-regulated during inflammation and promotes the recruitment of T cells and ..
  8. Chen H, Wang P, Aravindaram K, Chen Y, Yu H, Yang W, et al. Shikonin enhances efficacy of a gene-based cancer vaccine via induction of RANTES. J Biomed Sci. 2012;19:42 pubmed publisher
    ..The present study hence employs these various components for experimentation. The mRNA and protein expression of RANTES were detected by RT-PCR and ELISA, respectively...
  9. Terao S, Yilmaz G, Stokes K, Russell J, Ishikawa M, Kawase T, et al. Blood cell-derived RANTES mediates cerebral microvascular dysfunction, inflammation, and tissue injury after focal ischemia-reperfusion. Stroke. 2008;39:2560-70 pubmed publisher
    ..This study tested the hypothesis that RANTES (CCL5; regulated on activation, normal T-cell expressed and secreted) mediates the cerebral microvascular ..
  10. Luo Y, Berman M, Zhai Q, Fischer F, Abromson Leeman S, Zhang Y, et al. RANTES stimulates inflammatory cascades and receptor modulation in murine astrocytes. Glia. 2002;39:19-30 pubmed
    Cultured mouse astrocytes respond to the CC chemokine RANTES by production of chemokine and cytokine transcripts...
  11. Zhang H, Yang H, Ma W, He S. Induction of IL-13 production and upregulated expression of protease activated receptor-1 by RANTES in a mast cell line. Cytokine. 2011;53:231-8 pubmed publisher
    b>RANTES is a potent chemoattractant for various important inflammatory cells such as eosinophils, memory T cells and mast cells. It has been long recognized as a crucial player in the pathogenesis of allergy...
  12. Hara T, Bacon K, Cho L, Yoshimura A, Morikawa Y, Copeland N, et al. Molecular cloning and functional characterization of a novel member of the C-C chemokine family. J Immunol. 1995;155:5352-8 pubmed
    ..These results clearly indicate that CCF18 is a new member of the C-C chemokine family. Since a high level of CCF18 mRNA is constitutively expressed in macrophage and myeloid cell lines, CCF18 may play a role in inflammatory processes. ..
  13. Nancy P, Tagliani E, Tay C, Asp P, Levy D, Erlebacher A. Chemokine gene silencing in decidual stromal cells limits T cell access to the maternal-fetal interface. Science. 2012;336:1317-21 pubmed publisher
    ..These findings give insight into mechanisms of fetomaternal immune tolerance, as well as reveal the epigenetic modification of tissue stromal cells as a modality for limiting effector T cell trafficking...
  14. Fischer F, Luo Y, Luo M, Santambrogio L, Dorf M. RANTES-induced chemokine cascade in dendritic cells. J Immunol. 2001;167:1637-43 pubmed
    ..Murine bone marrow-derived DC respond to the CC chemokine RANTES (10-100 ng/ml) by production of proinflammatory mediators...
  15. Ban Y, Mai J, Li X, Mitchell Flack M, Zhang T, Zhang L, et al. Targeting Autocrine CCL5-CCR5 Axis Reprograms Immunosuppressive Myeloid Cells and Reinvigorates Antitumor Immunity. Cancer Res. 2017;77:2857-2868 pubmed publisher
    The tumor-promoting potential of CCL5 has been proposed but remains poorly understood...
  16. Sierro F, Evrard M, Rizzetto S, Melino M, Mitchell A, Flórido M, et al. A Liver Capsular Network of Monocyte-Derived Macrophages Restricts Hepatic Dissemination of Intraperitoneal Bacteria by Neutrophil Recruitment. Immunity. 2017;47:374-388.e6 pubmed publisher
    ..Thus, the liver contains two separate and non-overlapping niches occupied by distinct resident macrophage populations mediating immunosurveillance at these two pathogen entry points to the liver. ..
  17. Zhang J, Luo J, Liu F, Wu D, Zhong Q, Zeng L, et al. Diabetes mellitus potentiates diffuse large B?cell lymphoma via high levels of CCL5. Mol Med Rep. 2014;10:1231-6 pubmed publisher
    There is much evidence suggesting that CCL5 is one of the chemoattractant cytokines involved in diabetes mellitus (DM) with diffuse large B?cell lymphoma (DLBCL). However, the pathological impact is unclear...
  18. Kimura K, Nagano M, Salazar G, Yamashita T, Tsuboi I, Mishima H, et al. The role of CCL5 in the ability of adipose tissue-derived mesenchymal stem cells to support repair of ischemic regions. Stem Cells Dev. 2014;23:488-501 pubmed publisher
    ..We evaluated the mRNA expression of angiogenic and migration factors in MSC and found the expression of CCL5 mRNA was higher in AT-MSC than in BM-MSC or DT-MSC...
  19. Dos Santos A, Roffe E, Arantes R, Juliano L, Pesquero J, Pesquero J, et al. Kinin B2 receptor regulates chemokines CCL2 and CCL5 expression and modulates leukocyte recruitment and pathology in experimental autoimmune encephalomyelitis (EAE) in mice. J Neuroinflammation. 2008;5:49 pubmed publisher
    ..We have previously shown that the chemokines CCL2 and CCL5 play an important role in the adhesion of leukocytes to the brain microcirculation in EAE...
  20. Swamydas M, Ricci K, Rego S, Dreau D. Mesenchymal stem cell-derived CCL-9 and CCL-5 promote mammary tumor cell invasion and the activation of matrix metalloproteinases. Cell Adh Migr. 2013;7:315-24 pubmed publisher
    ..Results indicate that mesenchymal D1 cells produced concentrations of CCL5 and CCL9 4- to 5-fold higher than the concentrations secreted by 4T1 tumor cells (P < 0.01)...
  21. Suga H, Sugaya M, Fujita H, Asano Y, Tada Y, Kadono T, et al. TLR4, rather than TLR2, regulates wound healing through TGF-? and CCL5 expression. J Dermatol Sci. 2014;73:117-24 pubmed publisher
    ..after wounding, accompanied by decreased numbers of infiltrating macrophages in the dermis and decreased TGF-? and CCL5 mRNA expression in the wounded skin...
  22. Forst B, Hansen M, Klingelhöfer J, Møller H, Nielsen G, Grum Schwensen B, et al. Metastasis-inducing S100A4 and RANTES cooperate in promoting tumor progression in mice. PLoS ONE. 2010;5:e10374 pubmed publisher
    ..interplay between the tumor cell-derived cytokine regulated-upon-activation, normal T-cell expressed and secreted (RANTES; CCL5) and S100A4 which were shown to be critical factors in tumor progression...
  23. Vesosky B, Rottinghaus E, Stromberg P, Turner J, Beamer G. CCL5 participates in early protection against Mycobacterium tuberculosis. J Leukoc Biol. 2010;87:1153-65 pubmed publisher
    ..tb-protective T(H)1 responses, may identify targets that could accelerate granuloma formation. The chemokine CCL5 has been detected in patients with TB and implicated in control of M.tb infection...
  24. Neugarten J, Feith G, Assmann K, Shan Z, Stanley E, Schlondorff D. Role of macrophages and colony-stimulating factor-1 in murine antiglomerular basement membrane glomerulonephritis. J Am Soc Nephrol. 1995;5:1903-9 pubmed
    ..macrophage-related cytokines, colony stimulating factor-1 (CSF-1), monocyte chemoattractant protein-1 (MCP-1) and RANTES, accelerated anti-GBM nephritis was studied in op/op mutant mice, which lack CSF-1 and are severely macrophage ..
  25. Ondondo B, Colbeck E, Jones E, Smart K, Lauder S, Hindley J, et al. A distinct chemokine axis does not account for enrichment of Foxp3(+)  CD4(+) T cells in carcinogen-induced fibrosarcomas. Immunology. 2015;145:94-104 pubmed publisher
    ..These analyses revealed that the tumours are characterized by expression of inflammatory chemokines (CCL2, CCL5, CCL7, CCL8, CCL12, CXCL9, CXCL10 and CX3CL1), reflected by an enrichment of activated Foxp3(-) and Foxp3(+) T ..
  26. Liou G, Döppler H, Necela B, Krishna M, Crawford H, Raimondo M, et al. Macrophage-secreted cytokines drive pancreatic acinar-to-ductal metaplasia through NF-?B and MMPs. J Cell Biol. 2013;202:563-77 pubmed publisher
    ..We identify the macrophage-secreted inflammatory cytokines RANTES and tumor necrosis factor ? (TNF) as mediators of such signaling...
  27. Wang X, Yang X, Tsai Y, Yang L, Chuang K, Keng P, et al. IL-6 Mediates Macrophage Infiltration after Irradiation via Up-regulation of CCL2/CCL5 in Non-small Cell Lung Cancer. Radiat Res. 2017;187:50-59 pubmed publisher
    ..In mechanistic dissection studies, radiation-induced up-regulation of CCL2 and CCL5 by IL-6 was detected, and blocking the action of CCL2/CCL5 molecules significantly reduced the number of migrated ..
  28. Chenoweth M, Mian M, Barra N, Alain T, Sonenberg N, Bramson J, et al. IL-15 can signal via IL-15R?, JNK, and NF-?B to drive RANTES production by myeloid cells. J Immunol. 2012;188:4149-57 pubmed publisher
    ..Furthermore, treatment with IL-15 induced RANTES production by Rag2(-/-)?(c)(-/-) bone marrow cells, but the presence of ?(c) did not increase bone marrow cell ..
  29. Manils J, Casas E, Vina Vilaseca A, López Cano M, Díez Villanueva A, Gómez D, et al. The Exonuclease Trex2 Shapes Psoriatic Phenotype. J Invest Dermatol. 2016;136:2345-2355 pubmed publisher
    ..Hence, our data indicate that Trex2 acts as a critical factor in the pathogenesis of psoriasis by promoting keratinocyte apoptosis and enucleation and thereby influencing skin immune responses. ..
  30. Serrels A, Lund T, Serrels B, Byron A, McPherson R, von Kriegsheim A, et al. Nuclear FAK controls chemokine transcription, Tregs, and evasion of anti-tumor immunity. Cell. 2015;163:160-73 pubmed publisher
    ..microenvironment by regulating chemokine/cytokine and ligand-receptor networks, including via transcription of Ccl5, which is crucial...
  31. Tsuji D, Kuroki A, Ishibashi Y, Itakura T, Kuwahara J, Yamanaka S, et al. Specific induction of macrophage inflammatory protein 1-alpha in glial cells of Sandhoff disease model mice associated with accumulation of N-acetylhexosaminyl glycoconjugates. J Neurochem. 2005;92:1497-507 pubmed
    ..On the other hand, little changes in other chemokine mRNAs, including those of RANTES (regulated upon activation, normal T expressed and secreted), MCP-1 (monocyte chemotactic protein-1), SLC (..
  32. Keepers T, Gross L, Obrig T. Monocyte chemoattractant protein 1, macrophage inflammatory protein 1 alpha, and RANTES recruit macrophages to the kidney in a mouse model of hemolytic-uremic syndrome. Infect Immun. 2007;75:1229-36 pubmed
    ..monocyte chemoattractant protein 1 (MCP-1/CCL2), macrophage inflammatory protein 1alpha (MIP-1alpha/CCL3), and RANTES (CCL5), in a pattern that was coincident with macrophage infiltration as indicated by immunohistochemistry, ..
  33. Zhang Q, Qin J, Zhong L, Gong L, Zhang B, Zhang Y, et al. CCL5-Mediated Th2 Immune Polarization Promotes Metastasis in Luminal Breast Cancer. Cancer Res. 2015;75:4312-21 pubmed publisher
    The tumor-promoting chemokine CCL5 has been implicated in malignant transformation of breast epithelial cells, with studies to date focusing mainly on basal-type breast cancers...
  34. Wintges K, Beil F, Albers J, Jeschke A, Schweizer M, Claass B, et al. Impaired bone formation and increased osteoclastogenesis in mice lacking chemokine (C-C motif) ligand 5 (Ccl5). J Bone Miner Res. 2013;28:2070-80 pubmed publisher
    ..Because we have previously observed that chemokine (C-C motif) ligand 2 (Ccl2) and Ccl5 are direct target genes of noncanonical Wnt signaling in osteoblasts, we analyzed the skeletal phenotypes of Ccl2-..
  35. Di Prisco S, Summa M, Chellakudam V, Rossi P, Pittaluga A. RANTES-mediated control of excitatory amino acid release in mouse spinal cord. J Neurochem. 2012;121:428-37 pubmed publisher
    The impact of Regulated upon Activation Normal T cells Expressed and Secreted (RANTES) on the release of pre-loaded [³H]D-aspartate ([³H]D-ASP) from mouse spinal cord synaptosomes was investigated. RANTES (0...
  36. Laan M, Kisand K, Kont V, Möll K, Tserel L, Scott H, et al. Autoimmune regulator deficiency results in decreased expression of CCR4 and CCR7 ligands and in delayed migration of CD4+ thymocytes. J Immunol. 2009;183:7682-91 pubmed publisher
    ..These results suggest a novel mechanism behind the Aire-dependent induction of central tolerance. ..
  37. Kovacic J, Gupta R, Lee A, Ma M, Fang F, Tolbert C, et al. Stat3-dependent acute Rantes production in vascular smooth muscle cells modulates inflammation following arterial injury in mice. J Clin Invest. 2010;120:303-14 pubmed publisher
    ..studied these events in mice and found that immediately following arterial injury, medial VSMCs upregulated Rantes in an acute manner dependent on Stat3 and NF-kappaB (p65 subunit)...
  38. Glabinski A, Tuohy V, Ransohoff R. Expression of chemokines RANTES, MIP-1alpha and GRO-alpha correlates with inflammation in acute experimental autoimmune encephalomyelitis. Neuroimmunomodulation. 1998;5:166-71 pubmed
    ..In the present study we analyzed the gene expression of three chemokines, RANTES, MIP-1alpha and GRO-alpha, at the onset of acute EAE, and correlated that expression with the intensity of ..
  39. Takashima K, Takeda Y, Oshiumi H, Shime H, Okabe M, Ikawa M, et al. STING in tumor and host cells cooperatively work for NK cell-mediated tumor growth retardation. Biochem Biophys Res Commun. 2016;478:1764-71 pubmed publisher
    ..suggested that STING in host immune cells and tumor cells induced distinct profiles of chemokines including CXCL10, CCL5 and IL-33, and both participated in NK cell infiltration and activation in B16D8 tumor...
  40. Hardbower D, Asim M, Luis P, Singh K, Barry D, Yang C, et al. Ornithine decarboxylase regulates M1 macrophage activation and mucosal inflammation via histone modifications. Proc Natl Acad Sci U S A. 2017;114:E751-E760 pubmed publisher
    ..Thus, ODC in macrophages tempers antimicrobial, M1 macrophage responses during bacterial infections through histone modifications and altered euchromatin formation, leading to the persistence and pathogenesis of these organisms. ..
  41. Cohen Tannoudji M, Vandormael Pournin S, Le Bras S, Coumailleau F, Babinet C, Baldacci P. A 2-Mb YAC/BAC-based physical map of the ovum mutant (Om) locus region on mouse chromosome 11. Genomics. 2000;68:273-82 pubmed
    ..Two other genes (Rad51l3 and Schlafen 2) and one EST (D11Wsu78e) were also mapped in the Om region. This integrated map provides support for the identification of additional candidate genes for the DDK syndrome. ..
  42. Mello Coelho V, Bunbury A, Rangel L, Giri B, Weeraratna A, Morin P, et al. Fat-storing multilocular cells expressing CCR5 increase in the thymus with advancing age: potential role for CCR5 ligands on the differentiation and migration of preadipocytes. Int J Med Sci. 2009;7:1-14 pubmed
    ..We verified that the expression of CCR5 and its ligands, CCL3, CCL4 and CCL5, were increased in the thymus with age...
  43. Fan Y, Wen C, Xie Z. [Effects of three Chinese herbal antidotes (Herba artemisiae annuae, Herba hedyotis diffusae and Rhizoma cimicifugae) and their different combinations on regulated on activation normal T cell expressed and secreated expression in MRL/lpr mice]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2010;30:1306-9 pubmed
    ..H) and Rhizoma Cimicifugae (C), all were ingredients of Jiedu Quyu Ziyin Recipe, for adjusting the regulated on activation normal T cell expressed and secreated (RANTES), gene expression in serum and renal tissue of MRL/lpr mice.
  44. Nookala A, Shah A, Noel R, Kumar A. HIV-1 Tat-mediated induction of CCL5 in astrocytes involves NF-?B, AP-1, C/EBP? and C/EBP? transcription factors and JAK, PI3K/Akt and p38 MAPK signaling pathways. PLoS ONE. 2013;8:e78855 pubmed publisher
    ..HIV-1 Tat is known to up-regulate CCL5 expression in mouse astrocytes, but the mechanism of up-regulation is not known...
  45. Nasser M, Marjoram R, Brown S, Richardson R. Cross-desensitization among CXCR1, CXCR2, and CCR5: role of protein kinase C-epsilon. J Immunol. 2005;174:6927-33 pubmed
    ..Because DeltaCXCR2, but not CXCR2, activates PKCepsilon and cross-desensitizes CCR5, the data further suggest that signal duration leading to activation of novel PKC may modulate receptor-mediated cross-inhibitory signals. ..
  46. Nesbeth Y, Martinez D, Toraya S, Scarlett U, Cubillos Ruiz J, Rutkowski M, et al. CD4+ T cells elicit host immune responses to MHC class II-negative ovarian cancer through CCL5 secretion and CD40-mediated licensing of dendritic cells. J Immunol. 2010;184:5654-62 pubmed publisher
    ..mechanism whereby tumor-primed CD4(+) T cells transferred into ovarian cancer-bearing mice secrete high levels of CCL5, which recruits endogenous CCR5(+) dendritic cells to tumor locations and activate them through CD40-CD40L ..
  47. Laubli H, Spanaus K, Borsig L. Selectin-mediated activation of endothelial cells induces expression of CCL5 and promotes metastasis through recruitment of monocytes. Blood. 2009;114:4583-91 pubmed publisher
    ..cells with platelets and leukocytes activated endothelial cells and induced production of C-C chemokine ligand 5 (CCL5)...
  48. Villegas Mendez A, Gwyer Findlay E, de Souza J, Grady L, Saris C, Lane T, et al. WSX-1 signalling inhibits CD4? T cell migration to the liver during malaria infection by repressing chemokine-independent pathways. PLoS ONE. 2013;8:e78486 pubmed publisher
    ..Although CCL4 and CCL5 expression was higher in livers of infected WSX-1(-/-) mice than infected WT mice, and hepatic CD4? T cells from ..
  49. Mohs A, Kuttkat N, Reißing J, Zimmermann H, Sonntag R, Proudfoot A, et al. Functional role of CCL5/RANTES for HCC progression during chronic liver disease. J Hepatol. 2017;66:743-753 pubmed publisher
    ..In the present study we investigated the role of CCL5 in human and in murine models of chronic liver inflammation leading to hepatocellular carcinoma (HCC) development...
  50. Egunsola A, Zawislak C, Akuffo A, Chalmers S, Ewer J, Vail C, et al. Growth, metastasis, and expression of CCL2 and CCL5 by murine mammary carcinomas are dependent upon Myd88. Cell Immunol. 2012;272:220-9 pubmed publisher
    ..reduced levels of Myd88 correlated with a significant reduction in lung metastasis as well as decreased CCL2 and CCL5 expression...
  51. Machlus K, Johnson K, Kulenthirarajan R, Forward J, Tippy M, Soussou T, et al. CCL5 derived from platelets increases megakaryocyte proplatelet formation. Blood. 2016;127:921-6 pubmed publisher
    ..Platelets store inflammatory cytokines, including the chemokine ligand 5 (CCL5, RANTES); after TRAP activation, platelets release over 25 ng/mL CCL5...
  52. Adada M, Orr Gandy K, Snider A, Canals D, Hannun Y, Obeid L, et al. Sphingosine kinase 1 regulates tumor necrosis factor-mediated RANTES induction through p38 mitogen-activated protein kinase but independently of nuclear factor ?B activation. J Biol Chem. 2013;288:27667-79 pubmed publisher
    ..Here, we find that loss of SK1 potentiates induction of the chemokine RANTES (regulated on activation, normal T cell expressed and secreted; also known as CCL5) in HeLa cells stimulated with ..
  53. Schober A, Manka D, von Hundelshausen P, Huo Y, Hanrath P, Sarembock I, et al. Deposition of platelet RANTES triggering monocyte recruitment requires P-selectin and is involved in neointima formation after arterial injury. Circulation. 2002;106:1523-9 pubmed
    ..Using immunofluorescence and laminar flow assays, we found that the deposition of the platelet-derived chemokine RANTES and monocyte arrest subsequently triggered by RANTES immobilized on inflamed endothelium are more efficient after ..
  54. Yu T, Palanisamy K, Sun K, Day Y, Shu K, Wang I, et al. RANTES mediates kidney ischemia reperfusion injury through a possible role of HIF-1α and LncRNA PRINS. Sci Rep. 2016;6:18424 pubmed publisher
    b>RANTES (Regulated on activation, normal T-cell expressed and secreted), recruits circulating leukocytes and augments inflammatory responses in many clinical conditions...
  55. Lin W, Zhang J, Lin H, Li Z, Sun X, Xin D, et al. Syndecan-4 negatively regulates antiviral signalling by mediating RIG-I deubiquitination via CYLD. Nat Commun. 2016;7:11848 pubmed publisher
    ..Collectively, our findings uncover a mechanism by which SDC4 antagonizes the activation of RIG-I in a CYLD-mediated deubiquitination-dependent process, thereby balancing antiviral signalling to avoid deleterious effects on host cells. ..
  56. Post T, Bozic C, Rothenberg M, Luster A, Gerard N, Gerard C. Molecular characterization of two murine eosinophil beta chemokine receptors. J Immunol. 1995;155:5299-305 pubmed
    beta or C-C chemokines including RANTES, MCP-3, MIP-1 alpha, and eotaxin have been implicated in the pathogenesis of eosinophilic inflammation...
  57. Gao D, Cazares L, Fish E. CCL5-CCR5 interactions modulate metabolic events during tumor onset to promote tumorigenesis. BMC Cancer. 2017;17:834 pubmed publisher
    In earlier studies we have shown that CCL5 activation of CCR5 induces the proliferation and survival of breast cancer cells in a mechanistic target of rapamycin (mTOR)-dependent manner and that this is in part due to CCR5-mediated ..
  58. Li S, Pettersson U, Hoorelbeke B, Kolaczkowska E, Schelfhout K, Martens E, et al. Interference with glycosaminoglycan-chemokine interactions with a probe to alter leukocyte recruitment and inflammation in vivo. PLoS ONE. 2014;9:e104107 pubmed publisher
    ..sulphate bound the mouse CXC chemokines KC/CXCL1, MIP-2/CXCL2, IP-10/CXCL10 and I-TAC/CXCL11 and the CC chemokine RANTES/CCL5 with affinities in the nanomolar range, whereas no binding interactions were observed for mouse MCP-1/CCL2, ..
  59. Mause S, von Hundelshausen P, Zernecke A, Koenen R, Weber C. Platelet microparticles: a transcellular delivery system for RANTES promoting monocyte recruitment on endothelium. Arterioscler Thromb Vasc Biol. 2005;25:1512-8 pubmed
    Platelet activation mediates multiple cellular responses, including secretion of chemokines such as RANTES (CCL5), and formation of platelet microparticles (PMPs)...
  60. Kim Y, Kim Y, An D, Kwon H. Characterization of lipopolysaccharide responsive proteins that binds to the 5'-flanking regions of mouse Rantes. Mol Cells. 2002;13:91-8 pubmed
    ..with lipopolysaccharide (LPS), factors that bind specifically to the LPS responsive element (LRE) of murine Rantes gene appeared in the nucleus...
  61. Aswad M, Assi S, Schif Zuck S, Ariel A. CCL5 Promotes Resolution-Phase Macrophage Reprogramming in Concert with the Atypical Chemokine Receptor D6 and Apoptotic Polymorphonuclear Cells. J Immunol. 2017;199:1393-1404 pubmed publisher
    ..In this study, we found that the inflammatory chemokine CCL5 is mostly retained (75%) during the resolution of zymosan A peritonitis in mice...
  62. Culley F, Pennycook A, Tregoning J, Dodd J, Walzl G, Wells T, et al. Role of CCL5 (RANTES) in viral lung disease. J Virol. 2006;80:8151-7 pubmed
    CCL5/RANTES is a key proinflammatory chemokine produced by virus-infected epithelial cells and present in respiratory secretions of asthmatics...
  63. Zhou X, Shan Z, Liang H, Lin Z, Qiu S, Kuang F, et al. Role of regulated upon activation normal T-cell expressed and secreted in a model of retransplantation acute rejection mediated by alloreactive memory CD4+ T cells. Transplant Proc. 2013;45:546-51 pubmed publisher
    ..The experiment observed the influence of the chemokine RANTES in a mouse model of acute cardiac allograft rejection induced by adoptive transfer of alloreactive CD4(+) memory T ..
  64. Gregoire C, Cognet C, Chasson L, Coupet C, Dalod M, Reboldi A, et al. Intrasplenic trafficking of natural killer cells is redirected by chemokines upon inflammation. Eur J Immunol. 2008;38:2076-84 pubmed publisher
    ..This migration was dependent on both CXCR3 and CCL5, suggesting a synergy between CXCR3 and CCR5, and followed the path lined by fibroblastic reticular cells...
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    ..Here we found that IRF1 was essential for IL-1-induced expression of the chemokines CXCL10 and CCL5, which recruit mononuclear cells into sites of sterile inflammation...
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    ..These results suggest that T(regs) are important regulators of the homeostasis of CD8(+) T cell priming and play a critical role in the induction of high-avidity primary responses and effective memory. ..
  67. Yester J, Bryan L, Waters M, Mierzenski B, Biswas D, Gupta A, et al. Sphingosine-1-phosphate inhibits IL-1-induced expression of C-C motif ligand 5 via c-Fos-dependent suppression of IFN-β amplification loop. FASEB J. 2015;29:4853-65 pubmed publisher
    ..We found that whereas S1P promotes IL-1-induced expression of IL-6, it inhibits IL-1-induced CCL5 expression in astrocytes...
  68. Hu B, Elinav E, Huber S, Strowig T, Hao L, Hafemann A, et al. Microbiota-induced activation of epithelial IL-6 signaling links inflammasome-driven inflammation with transmissible cancer. Proc Natl Acad Sci U S A. 2013;110:9862-7 pubmed publisher
    ..Enhanced tumorigenesis is dependent on microbiota-induced chemokine (C-C motif) ligand 5 (CCL5)-driven inflammation, which in turn promotes epithelial cell proliferation through local activation of the IL-6 ..
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    ..In influenza virus infection, the respiratory tract released cytokines into the blood, such as RANTES that induced macrophage inflammatory protein-2 and other inflammatory mediators in the ischemic brain...
  70. Sax M, Gasch C, Athota V, Freeman R, Rasighaemi P, Westcott D, et al. Cancer cell CCL5 mediates bone marrow independent angiogenesis in breast cancer. Oncotarget. 2016;7:85437-85449 pubmed publisher
    ..Here we show that suppression of either cancer cell produced CCL5, or host CCR5 leads to distinctive vascular and tumor growth defects in breast cancer...
  71. Rudemiller N, Patel M, Zhang J, Jeffs A, Karlovich N, Griffiths R, et al. C-C Motif Chemokine 5 Attenuates Angiotensin II-Dependent Kidney Injury by Limiting Renal Macrophage Infiltration. Am J Pathol. 2016;186:2846-2856 pubmed publisher
    ..C-C motif chemokine 5 (CCL5) drives recruitment of macrophages and T lymphocytes into injured tissues, and we have found that RAS activation ..
  72. Faunce D, Stein Streilein J. NKT cell-derived RANTES recruits APCs and CD8+ T cells to the spleen during the generation of regulatory T cells in tolerance. J Immunol. 2002;169:31-8 pubmed either CD1d-transfected fibroblasts in vitro or CD1d(+) tolerogenic APCs both in vivo and ex vivo produced RANTES in a CD1d-dependent manner...
  73. Barcelos L, Coelho A, Russo R, Guabiraba R, Souza A, Bruno Lima G, et al. Role of the chemokines CCL3/MIP-1 alpha and CCL5/RANTES in sponge-induced inflammatory angiogenesis in mice. Microvasc Res. 2009;78:148-54 pubmed publisher
    ..Treatment of WT with the CCR1/CCR5 antagonist, Met-RANTES, prevented neutrophil and macrophage accumulation, but enhanced sponge vascularization...
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    ..Thus, spatial organization of the immune response by DCs between 6 and 24 hr ensures functional activation of innate cells, which restricts pathogens before adaptive immunity is fully activated. ..
  75. Yano S, Mentaverri R, Kanuparthi D, Bandyopadhyay S, Rivera A, Brown E, et al. Functional expression of beta-chemokine receptors in osteoblasts: role of regulated upon activation, normal T cell expressed and secreted (RANTES) in osteoblasts and regulation of its secretion by osteoblasts and osteoclasts. Endocrinology. 2005;146:2324-35 pubmed
    ..functions of receptors for the beta-chemokine, regulated upon activation, normal T cell expressed, and secreted (RANTES)/CCL5, were investigated in osteoblasts...
  76. Liu J, Guan X, Ma X. Interferon regulatory factor 1 is an essential and direct transcriptional activator for interferon {gamma}-induced RANTES/CCl5 expression in macrophages. J Biol Chem. 2005;280:24347-55 pubmed
    ..b>RANTES (regulated on activation normal T cell expressed and secreted; CCL5) is a member of the CC chemokine family of ..
  77. Krohn R, Raffetseder U, Bot I, Zernecke A, Shagdarsuren E, Liehn E, et al. Y-box binding protein-1 controls CC chemokine ligand-5 (CCL5) expression in smooth muscle cells and contributes to neointima formation in atherosclerosis-prone mice. Circulation. 2007;116:1812-20 pubmed
    The CC chemokine CCL5/Regulated on Activation, Normal T Cell Expressed and Secreted (RANTES) is upregulated in mononuclear cells or deposited by activated platelets during inflammation and has been implicated in atherosclerosis and ..
  78. Segerer S, Johnson Z, Rek A, Baltus T, von Hundelshausen P, Kungl A, et al. The basic residue cluster (55)KKWVR(59) in CCL5 is required for in vivo biologic function. Mol Immunol. 2009;46:2533-8 pubmed publisher
    ..b>CCL5 contains two clusters of basic amino acid residues ((44)RKNR(47) and (55)KKWVR(59)) implicated in presentation of ..
  79. Schiltz J, Kesari K, Ashar H, Chada K. Hmgi-c-independent Activation of MuRantes in Vivo. Cell Growth Differ. 2002;13:39-45 pubmed
    ..from macrophage cell lines has previously suggested that Hmgi-c is necessary for the inducible activation of MuRantes expression...
  80. Choi S, Hildebrandt G, Olkiewicz K, Hanauer D, Chaudhary M, Silva I, et al. CCR1/CCL5 (RANTES) receptor-ligand interactions modulate allogeneic T-cell responses and graft-versus-host disease following stem-cell transplantation. Blood. 2007;110:3447-55 pubmed
    ..T-cell function was partially dependent on interactions between CCR1 and CCL5. Collectively, these data demonstrate that CCR1 expression on donor cells contributes to the development of both ..
  81. Tsuzurahara F, Soeta S, Kawawa T, Baba K, Nakamura M. The role of macrophages in the disappearance of Meckel's cartilage during mandibular development in mice. Acta Histochem. 2011;113:194-200 pubmed publisher
  82. Demoule A, Divangahi M, Yahiaoui L, Danialou G, Gvozdic D, Petrof B. Chemokine receptor and ligand upregulation in the diaphragm during endotoxemia and Pseudomonas lung infection. Mediators Inflamm. 2009;2009:860565 pubmed publisher
    ..and molecular regulation of the chemokines, regulated upon activation normal T cell expressed and secreted (RANTES) and macrophage inflammatory protein (MIP)-1alpha, in the murine diaphragm during sepsis...
  83. Herold S, von Wulffen W, Steinmueller M, Pleschka S, Kuziel W, Mack M, et al. Alveolar epithelial cells direct monocyte transepithelial migration upon influenza virus infection: impact of chemokines and adhesion molecules. J Immunol. 2006;177:1817-24 pubmed
    ..the mouse-adapted influenza A virus strain PR/8 strongly induced the release of monocyte chemoattractants CCL2 and CCL5 followed by a strong monocyte transepithelial migration, and this monocytic response was strictly dependent on ..
  84. Fessele S, Maier H, Zischek C, Nelson P, Werner T. Regulatory context is a crucial part of gene function. Trends Genet. 2002;18:60-3 pubmed
    ..Using the human RANTES/CCL5 promoter, we show that organizational features of promoters derived from promoter sequences contain ..
  85. Ishida Y, Kimura A, Kuninaka Y, Inui M, Matsushima K, Mukaida N, et al. Pivotal role of the CCL5/CCR5 interaction for recruitment of endothelial progenitor cells in mouse wound healing. J Clin Invest. 2012;122:711-21 pubmed publisher
    ..Consistent with these observations, CCL5 induced in vitro EPC migration in a CCR5-dependent manner...
  86. Jenkins R, Clarke C, Canals D, Snider A, Gault C, Heffernan Stroud L, et al. Regulation of CC ligand 5/RANTES by acid sphingomyelinase and acid ceramidase. J Biol Chem. 2011;286:13292-303 pubmed publisher
    ..In the present study using a chemokine/cytokine screen, we identified the chemokine CCL5 (formerly known as RANTES) as a candidate-specific downstream target for aSMase...
  87. Braunersreuther V, Pellieux C, Pelli G, Burger F, Steffens S, Montessuit C, et al. Chemokine CCL5/RANTES inhibition reduces myocardial reperfusion injury in atherosclerotic mice. J Mol Cell Cardiol. 2010;48:789-98 pubmed publisher
    ..The aim of the present study was to investigate the effect of chemokine CCL5/RANTES antagonism in an in vivo mouse model of ischemia and reperfusion...
  88. Wood G, Hausmann E, Choudhuri R. Relative role of CSF-1, MCP-1/JE, and RANTES in macrophage recruitment during successful pregnancy. Mol Reprod Dev. 1997;46:62-9; discussion 69-70 pubmed
    ..macrophages may be recruited from the bone marrow pool through expression of other type 1 chemokines such as JE, RANTES, MIP-1 alpha, MIP-1 beta, IP-10, and KC...
  89. Wolf R, Mascia F, Dharamsi A, Howard O, Cataisson C, Bliskovski V, et al. Gene from a psoriasis susceptibility locus primes the skin for inflammation. Sci Transl Med. 2010;2:61ra90 pubmed publisher
    ..This study provides a pathogenetic psoriasis model using a psoriasis candidate gene to link the epidermis and innate immune system in inflammation priming, highlighting the S100A7A15-RAGE axis as a potential therapeutic target. ..