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Genomes and Genes
| Ccl5SummaryGene Symbol: Ccl5 Description: chemokine (C-C motif) ligand 5 Alias: MuRantes, RANTES, SISd, Scya5, TCP228, C-C motif chemokine 5, SIS-delta, T-cell-specific protein RANTES, small inducible cytokine A5, small-inducible cytokine A5 Species: mouse Top Publications
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Publications
Inducible lung-specific expression of RANTES: preferential recruitment of neutrophilsZ Z Pan
Pulmonary and Critical Care Section, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
Am J Physiol Lung Cell Mol Physiol 279:L658-66. 2000The chemokine regulated on activation normal T cells expressed and secreted (RANTES) has been implicated in eosinophil chemotaxis in asthma and allergic diseases, which are thought to be T helper (Th) type 2-dominated diseases...- Role of RANTES in the development of autoimmune tissue injuries in MRL-Fas lpr miceTsunemichi Tsukahara
Department of Medicine and Clinical Oncology, Chiba University Graduate School of Medicine, Chiba, Japan
Clin Immunol 103:89-97. 2002..To investigate the possible role of RANTES in autoimmune tissue injuries, we have constructed RANTES-deficient MRL-Fas lpr mice by gene targeting... - GM-CSF DNA induces specific patterns of cytokines and chemokines in the skin: implications for DNA vaccinesMiguel Angel Perales
The Swim Across America Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Cytokines Cell Mol Ther 7:125-33. 2002..The early response was characterized by high levels of inflammatory molecules, including IL-1beta, IL-6, TNFalpha, RANTES, MIP-1alpha and MCP-1, later followed by expression of precursor Th1 cytokines, IL-12 and IL-18, concomitant with .. 
Involvement of the chemokine RANTES (CCL5) in resistance to experimental infection with Leishmania majorHelton da Costa Santiago
Departamento de Bioquimica e Imunologia, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Brazil
Infect Immun 72:4918-23. 2004The expression and putative role of chemokines during infection with Leishmania major in mice were investigated. CCL5 expression correlates with resistance, and blockade of CCL5 rendered mice more susceptible to infection...- The K1 serotype capsular polysaccharide of Porphyromonas gingivalis elicits chemokine production from murine macrophages that facilitates cell migrationGabriela d'Empaire
Department of Oral Biology and Periodontology, Goldman School of Dental Medicine, Boston University Medical Center, MA 02118, USA
Infect Immun 74:6236-43. 2006..We also defined JE/MCP-1, KC, MIP-2, and RANTES production in response to the P. gingivalis CPS antigens... - Chemokine gene expression in the brains of mice with lymphocytic choriomeningitisV C Asensio
Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037, USA
J Virol 71:7832-40. 1997..from the greatest to the least): cytokine responsive gene-2 or interferon-inducible 10-kDa protein (Crg-2/IP-10), RANTES, monocyte chemotactic protein-1 (MCP-1), macrophage inflammatory protein-1 (MIP-1beta), and MCP-3... - Chemokine expression during the development and resolution of a pulmonary leukocyte response to influenza A virus infection in miceMark D Wareing
La Jolla Institute for Allergy and Immunology, San Diego, CA, USA
J Leukoc Biol 76:886-95. 2004..protein 1alpha (MIP-1alpha), MIP-1beta, MIP-3alpha, regulated on activation, normal T expressed and secreted (RANTES), MIP-2, and interferon-inducible protein 10 (IP-10) mRNA expression was up-regulated between days 5 and 15 after .. - CCL5-CCR5 interaction provides antiapoptotic signals for macrophage survival during viral infectionJeffrey W Tyner
Department of Medicine, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
Nat Med 11:1180-7. 2005..Here we identify one such mechanism. We show that mice lacking the chemokine Ccl5 are immune compromised to the point of delayed viral clearance, excessive airway inflammation and respiratory death .. - Impaired T cell function in RANTES-deficient miceYasuhiko Makino
Penn Center for Molecular Studies of Kidney Disease, Renal Electrolyte and Hypertension Division, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Clin Immunol 102:302-9. 2002The chemokine RANTES is a chemoattractant for monocytes and T cells and is postulated to participate in many aspects of the immune response... - Sequence polymorphisms in the chemokines Scya1 (TCA-3), Scya2 (monocyte chemoattractant protein (MCP)-1), and Scya12 (MCP-5) are candidates for eae7, a locus controlling susceptibility to monophasic remitting/nonrelapsing experimental allergic encephalomyC Teuscher
Department of Veterinary Pathobiology, University of Illinois at Urbana Champaign 61802, USA
J Immunol 163:2262-6. 1999..Similarly, cDNA sequence polymorphisms in Nos2, Scya3, Scya4, Scya5, Scya6, Scya7, Scya9, Scya10, and Scya11 were excluded as candidates for eae7... - Antibody targeting of the CC chemokine ligand 5 results in diminished leukocyte infiltration into the central nervous system and reduced neurologic disease in a viral model of multiple sclerosisWilliam G Glass
Center for Immunology and Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697, USA
J Immunol 172:4018-25. 2004..In this study, we administer a mAb directed against CCL5 to mice with established mouse hepatitis virus-induced demyelination and impaired motor skills... - CCL5 modulates pneumococcal immunity and carriageRavichandran Palaniappan
Mercer University, Atlanta, GA 30341, USA
J Immunol 176:2346-56. 2006..Recently, it has been shown that genetic polymorphisms can result in diminished expression of CCL5, which results in increased susceptibility to and progression of infectious diseases... - MIP-1alpha, MIP-1beta, RANTES, and ATAC/lymphotactin function together with IFN-gamma as type 1 cytokinesBrigitte G Dorner
Molecular Immunology, Robert Koch Institute, D 13353 Berlin, Germany
Proc Natl Acad Sci U S A 99:6181-6. 2002..inflammatory protein (MIP)-1alpha, MIP-1beta, regulated on activation normal T cell expressed and secreted (RANTES), and activation-induced, T cell-derived, and chemokine-related cytokine (ATAC)/lymphotactin are cosecreted to a .. - CCR1 and CC chemokine ligand 5 interactions exacerbate innate immune responses during sepsisTraci L Ness
Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
J Immunol 173:6938-48. 2004..CCR1 and CCL5 interactions markedly altered the inflammatory response in vivo and in vitro... - Controls for lung dendritic cell maturation and migration during respiratory viral infectionMitchell H Grayson
Division of Allergy and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
J Immunol 179:1438-48. 2007..Maturation and migration of lung cDCs depends on Ccl5 and Ccr5 signals because these events are significantly impaired in Ccl5(-/-) and Ccr5(-/-) mice... - Blood cell-derived RANTES mediates cerebral microvascular dysfunction, inflammation, and tissue injury after focal ischemia-reperfusionSatoshi Terao
Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130, USA
Stroke 39:2560-70. 2008..This study tested the hypothesis that RANTES (CCL5; regulated on activation, normal T-cell expressed and secreted) mediates the cerebral microvascular .. - Tumor-derived CCL5 does not contribute to breast cancer progressionMevan M Jayasinghe
Department Biology, Lafayette College, Easton, PA 18042, USA
Breast Cancer Res Treat 111:511-21. 2008Besides functioning as a chemotactic factor, CCL5 has been associated with progression of disease in women with breast cancer, immune modulation and metastasis... - Y-box binding protein-1 controls CC chemokine ligand-5 (CCL5) expression in smooth muscle cells and contributes to neointima formation in atherosclerosis-prone miceRegina Krohn
Institute for Molecular Cardiovascular Research, University Hospital Aachen, RWTH Aachen University, Aachen, Germany
Circulation 116:1812-20. 2007The CC chemokine CCL5/Regulated on Activation, Normal T Cell Expressed and Secreted (RANTES) is upregulated in mononuclear cells or deposited by activated platelets during inflammation and has been implicated in atherosclerosis and .. - CCR1/CCL5 (RANTES) receptor-ligand interactions modulate allogeneic T-cell responses and graft-versus-host disease following stem-cell transplantationSung W Choi
Department of Pediatrics, Blood and Marrow Transplantation Program, University of Michigan, Ann Arbor, MI, USA
Blood 110:3447-55. 2007..T-cell function was partially dependent on interactions between CCR1 and CCL5. Collectively, these data demonstrate that CCR1 expression on donor cells contributes to the development of both .. - Interferon regulatory factor 8 regulates RANTES gene transcription in cooperation with interferon regulatory factor-1, NF-kappaB, and PU.1Jianguo Liu
Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York 10021, USA
J Biol Chem 281:19188-95. 2006..Regulated on activation, normal T cell expressed and secreted (RANTES, or CCL5) is a member of the CC chemokine family of proteins, strongly chemoattractant for several important .. - Cross-desensitization among CXCR1, CXCR2, and CCR5: role of protein kinase C-epsilonMohd W Nasser
Julius L Chambers Biomedical Biotechnology Research Institute, North Carolina Central University, Durham, 27707, USA
J Immunol 174:6927-33. 2005..Because DeltaCXCR2, but not CXCR2, activates PKCepsilon and cross-desensitizes CCR5, the data further suggest that signal duration leading to activation of novel PKC may modulate receptor-mediated cross-inhibitory signals... - Serial analysis of gene expression in progressing and regressing mouse tumors implicates the involvement of RANTES and TARC in antitumor immune responsesYukoh Nakazaki
Division of Molecular and Clinical Genetics, Medical Institute of Bioregulation, Kyushu University Hospital, Kyushu University, Fukuoka 812 8582, Japan
Mol Ther 14:599-606. 2006..Focusing on the chemokine genes TARC and RANTES, which were preferentially expressed in the GM-CSF-transduced tumors, their forced expression on mouse tumor cells .. - Platelet microparticles: a transcellular delivery system for RANTES promoting monocyte recruitment on endotheliumSebastian F Mause
Department of Molecular Cardiovascular Research, University Hospital, Aachen, Germany
Arterioscler Thromb Vasc Biol 25:1512-8. 2005Platelet activation mediates multiple cellular responses, including secretion of chemokines such as RANTES (CCL5), and formation of platelet microparticles (PMPs)... - Cell-autonomous CCL5 transcription by memory CD8 T cells is regulated by IL-4Antoine Marcais
Institut National de la Sante de la Recherche Medicale, Unité 503, 21 Avenue Tony Garnier, Lyon, France
J Immunol 177:4451-7. 2006..The maintenance by CD8 memory cells of high levels of untranslated CCL5 mRNA allows these cells to immediately secrete this chemokine upon Ag stimulation... - CCL5 regulation of mucosal chlamydial immunity and infectionSenthilkumar K Sakthivel
Emory University School of Medicine, Department of Pathology, Atlanta GA, USA
BMC Microbiol 8:136. 2008..We have shown that CCR5, a receptor for CCL5, is crucial for protective chlamydial immunity... - CCL5/RANTES gene deletion attenuates opioid-induced increases in glial CCL2/MCP-1 immunoreactivity and activation in HIV-1 Tat-exposed miceNazira El-Hage
Department of Pharmacology and Toxicology, Virginia Commonwealth University School of Medicine, 1217 East Marshall Street, Richmond, VA 23298 0613, USA
J Neuroimmune Pharmacol 3:275-85. 2008To assess the role of CC-chemokine ligand 5 (CCL5)/RANTES in opiate drug abuse and human immunodeficiency virus type 1 (HIV-1) comorbidity, the effects of systemic morphine and intrastriatal HIV-1 Tat on macrophage/microglial and .. - A role for the chemokine RANTES in regulating CD8 T cell responses during chronic viral infectionAlison Crawford
Department of Microbiology and Institute for Immunology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
PLoS Pathog 7:e1002098. 2011b>RANTES (CCL5) is a chemokine expressed by many hematopoietic and non-hematopoietic cell types that plays an important role in homing and migration of effector and memory T cells during acute infections... - Regulation of CC ligand 5/RANTES by acid sphingomyelinase and acid ceramidaseRussell W Jenkins
Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina 29425, USA
J Biol Chem 286:13292-303. 2011..In the present study using a chemokine/cytokine screen, we identified the chemokine CCL5 (formerly known as RANTES) as a candidate-specific downstream target for aSMase... 
Influenza virus infection aggravates stroke outcomeSajjad Muhammad
Department of Pharmacology, University of Heidelberg, Im Neuenheimer Feld 366, 69120 Heidelberg, Germany
Stroke 42:783-91. 2011..Stroke is triggered by several risk factors, including influenza and other respiratory tract infections. However, it is unknown how and in which way influenza infection affects stroke outcome...- Antagonism of the chemokine Ccl5 ameliorates experimental liver fibrosis in miceMarie Luise Berres
Medical Department III, University Hospital Aachen, Aachen, Germany
J Clin Invest 120:4129-40. 2010..Herein, we identify the chemokine CCL5 (also known as RANTES), which is induced in murine and human liver after injury, as a central mediator of this interaction... - V(alpha)14iNKT cells promote liver pathology during adenovirus infection by inducing CCL5 production: implications for gene therapyMaureen N Ajuebor
Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center Shreveport, Shreveport, Louisiana 71130, USA
J Virol 84:8520-9. 2010..in response to adenovirus infection to induce significant levels of hepatic chemokine (C-C motif) ligand 5 (CCL5) and subsequent liver toxicity... - Metastasis-inducing S100A4 and RANTES cooperate in promoting tumor progression in miceBirgitte Forst
Department for Molecular Cancer Biology, Danish Cancer Society, Copenhagen, Denmark
PLoS ONE 5:e10374. 2010..However, the events implicated in upstream and downstream pathways regulating the activity of the extracellular S100A4 protein in the tumor milieu remain unsolved... - CD4+ T cells elicit host immune responses to MHC class II-negative ovarian cancer through CCL5 secretion and CD40-mediated licensing of dendritic cellsYolanda C Nesbeth
Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, NH 03756, USA
J Immunol 184:5654-62. 2010..mechanism whereby tumor-primed CD4(+) T cells transferred into ovarian cancer-bearing mice secrete high levels of CCL5, which recruits endogenous CCR5(+) dendritic cells to tumor locations and activate them through CD40-CD40L .. - Fat-storing multilocular cells expressing CCR5 increase in the thymus with advancing age: potential role for CCR5 ligands on the differentiation and migration of preadipocytesValeria de Mello Coelho
Laboratories of Immunology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
Int J Med Sci 7:1-14. 2009..We verified that the expression of CCR5 and its ligands, CCL3, CCL4 and CCL5, were increased in the thymus with age... - Stat3-dependent acute Rantes production in vascular smooth muscle cells modulates inflammation following arterial injury in miceJason C Kovacic
Translational Medicine Branch, National Heart, Lung, and Blood Institute NIH, Bethesda, MD 20892, USA
J Clin Invest 120:303-14. 2010..studied these events in mice and found that immediately following arterial injury, medial VSMCs upregulated Rantes in an acute manner dependent on Stat3 and NF-kappaB (p65 subunit)... - Autoimmune regulator deficiency results in decreased expression of CCR4 and CCR7 ligands and in delayed migration of CD4+ thymocytesMartti Laan
Molecular Pathology Group, Institute of General and Molecular Pathology, Tartu University, Tartu, Estonia
J Immunol 183:7682-91. 2009..These results suggest a novel mechanism behind the Aire-dependent induction of central tolerance... - The basic residue cluster (55)KKWVR(59) in CCL5 is required for in vivo biologic functionStephan Segerer
University Hospital Zurich, Switzerland
Mol Immunol 46:2533-8. 2009..b>CCL5 contains two clusters of basic amino acid residues ((44)RKNR(47) and (55)KKWVR(59)) implicated in presentation of .. - Chemokine receptor and ligand upregulation in the diaphragm during endotoxemia and Pseudomonas lung infectionAlexandre Demoule
Meakins Christie Laboratories, McGill University, Montreal, QC, Canada H2X 2P2
Mediators Inflamm 2009:860565. 2009..and molecular regulation of the chemokines, regulated upon activation normal T cell expressed and secreted (RANTES) and macrophage inflammatory protein (MIP)-1alpha, in the murine diaphragm during sepsis... - The chemokine CCL5 is essential for leukocyte recruitment in a model of severe Herpes simplex encephalitisMárcia Carvalho Vilela
Departamento de Clinica Medica, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
Ann N Y Acad Sci 1153:256-63. 2009..Met-RANTES (regulated upon activation, normal T cell expressed and presumably secreted) (10 microg/mouse), a CC chemokine .. - Distinct intracellular signaling pathways control the synthesis of IL-8 and RANTES in TLR1/TLR2, TLR3 or NOD1 activated human airway epithelial cellsJulie Berube
Meakins Christie Laboratories, McGill University Heath Centre Research Institute, 3626 St Urbain, Montreal, Canada H2X 2P2
Cell Signal 21:448-56. 2009..capacity to up-regulate Interleukin-8 (IL-8) and Regulated upon Activation Normal T cell Expressed and Secreted (RANTES) in airway epithelial cells... - Regulation of hierarchical clustering and activation of innate immune cells by dendritic cellsSuk Jo Kang
Howard Hughes Medical Institute, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143 0795, USA
Immunity 29:819-33. 2008..Thus, spatial organization of the immune response by DCs between 6 and 24 hr ensures functional activation of innate cells, which restricts pathogens before adaptive immunity is fully activated... - Kinin B2 receptor regulates chemokines CCL2 and CCL5 expression and modulates leukocyte recruitment and pathology in experimental autoimmune encephalomyelitis (EAE) in miceAdriana C Dos Santos
Department of Physiology and Biophysics, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil
J Neuroinflammation 5:49. 2008..We have previously shown that the chemokines CCL2 and CCL5 play an important role in the adhesion of leukocytes to the brain microcirculation in EAE... - Interferon regulatory factor 1 is an essential and direct transcriptional activator for interferon {gamma}-induced RANTES/CCl5 expression in macrophagesJianguo Liu
Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York 10021, USA
J Biol Chem 280:24347-55. 2005..b>RANTES (regulated on activation normal T cell expressed and secreted; CCL5) is a member of the CC chemokine family of .. - Specific induction of macrophage inflammatory protein 1-alpha in glial cells of Sandhoff disease model mice associated with accumulation of N-acetylhexosaminyl glycoconjugatesDaisuke Tsuji
Department of Medicinal Biotechnology, Institute of Medicinal Resources, Graduate School of Pharmaceutical Sciences, The University of Tokushima, 1 78 Sho machi, Tokushima 770 8505, Japan
J Neurochem 92:1497-507. 2005..On the other hand, little changes in other chemokine mRNAs, including those of RANTES (regulated upon activation, normal T expressed and secreted), MCP-1 (monocyte chemotactic protein-1), SLC (.. - RANTES stimulates inflammatory cascades and receptor modulation in murine astrocytesYi Luo
Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
Glia 39:19-30. 2002Cultured mouse astrocytes respond to the CC chemokine RANTES by production of chemokine and cytokine transcripts... - A translational rheostat for RFLAT-1 regulates RANTES expression in T lymphocytesTania Nikolcheva
Department of Pediatrics, Stanford University School of Medicine, 300 Pasteur Drive, CCSR 2105, Stanford, CA 94305 5164, USA
J Clin Invest 110:119-26. 2002..begins late after T cell activation and involves expression of effector genes, including the chemokine RANTES and its major transcriptional regulator, RANTES factor of late-activated T lymphocytes-1 (RFLAT-1)... - NKT cell-derived RANTES recruits APCs and CD8+ T cells to the spleen during the generation of regulatory T cells in toleranceDouglas E Faunce
Schepens Eye Research Institute, Harvard Medical School, Boston, MA 02114, USA
J Immunol 169:31-8. 2002..by either CD1d-transfected fibroblasts in vitro or CD1d(+) tolerogenic APCs both in vivo and ex vivo produced RANTES in a CD1d-dependent manner... - Role of MCP-1 and RANTES in inflammation and progression to fibrosis during murine crescentic nephritisC M Lloyd
Department of Medicine, Boston University Medical Center, Massachusetts, USA
J Leukoc Biol 62:676-80. 1997..We have investigated the functional role that the chemokines monocyte chemotactic protein-1 (MCP-1) and RANTES play in inflammation and the progression to fibrosis during crescentic nephritis... - Expression of chemokines RANTES, MIP-1alpha and GRO-alpha correlates with inflammation in acute experimental autoimmune encephalomyelitisA R Glabinski
Department of Neurosciences, Cleveland Clinic Foundation, Cleveland, Ohio, USA
Neuroimmunomodulation 5:166-71. 1998..In the present study we analyzed the gene expression of three chemokines, RANTES, MIP-1alpha and GRO-alpha, at the onset of acute EAE, and correlated that expression with the intensity of .. - RANTES-mediated chemokine transcription in astrocytes involves activation and translocation of p90 ribosomal S6 protein kinase (RSK)Ye Zhang
Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
J Biol Chem 277:19042-8. 2002b>RANTES (regulated on activation normal T cell expressed and secreted) (> or =10 ng/ml) stimulates the induction of KC and other chemokines in astrocytes... - Isolation and characterization of cDNA from renal tubular epithelium encoding murine RantesP Heeger
Department of Medicine, University of Pennsylvania, Philadelphia
Kidney Int 41:220-5. 1992..In this report we have isolated cDNA encoding murine Rantes (MuRantes) from renal tubular epithelium (MCT cells)... - A 2-Mb YAC/BAC-based physical map of the ovum mutant (Om) locus region on mouse chromosome 11M Cohen-Tannoudji
Unite de Biologie du Developpement, CNRS URA 1960, Institut Pasteur, 25 rue du Dr Roux, Paris Cedex 15, 75724, France
Genomics 68:273-82. 2000..Two other genes (Rad51l3 and Schlafen 2) and one EST (D11Wsu78e) were also mapped in the Om region. This integrated map provides support for the identification of additional candidate genes for the DDK syndrome... - The role of CC chemokine receptor 5 (CCR5) and RANTES/CCL5 during chronic fungal asthma in miceJane M Schuh
Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
FASEB J 16:228-30. 2002..Immunoneutralization of RANTES/CCL5 in sensitized CCR5+/+ and CCR5-/- mice for 12 days after the conidia challenge significantly reduced the .. - RANTES-induced chemokine cascade in dendritic cellsF R Fischer
Department of Pathology, Harvard Medical School, Dana Farber Cancer Institute, 200 Longwood Avenue, Boston, MA 02115, USA
J Immunol 167:1637-43. 2001..Murine bone marrow-derived DC respond to the CC chemokine RANTES (10-100 ng/ml) by production of proinflammatory mediators... - Relative role of CSF-1, MCP-1/JE, and RANTES in macrophage recruitment during successful pregnancyG W Wood
Department of Pathology, University of Kansas Medical Center, Kansas City 66160 7410, USA
Mol Reprod Dev 46:62-9; discussion 69-70. 1997..macrophages may be recruited from the bone marrow pool through expression of other type 1 chemokines such as JE, RANTES, MIP-1 alpha, MIP-1 beta, IP-10, and KC... - Functional expression of beta-chemokine receptors in osteoblasts: role of regulated upon activation, normal T cell expressed and secreted (RANTES) in osteoblasts and regulation of its secretion by osteoblasts and osteoclastsShozo Yano
Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine and Membrane Biology Program, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Endocrinology 146:2324-35. 2005..functions of receptors for the beta-chemokine, regulated upon activation, normal T cell expressed, and secreted (RANTES)/CCL5, were investigated in osteoblasts... - Donor T-cell production of RANTES significantly contributes to the development of idiopathic pneumonia syndrome after allogeneic stem cell transplantationGerhard C Hildebrandt
Department of Pediatrics, Blood and Marrow Transplantation Program, University of Michigan, Ann Arbor, MI, USA
Blood 105:2249-57. 2005..b>RANTES is a chemokine ligand that is up-regulated during inflammation and promotes the recruitment of T cells and .. - Lymph node fibroblastic reticular cells construct the stromal reticulum via contact with lymphocytesTomoya Katakai
Center for Molecular Biology and Genetics, Kyoto University, 53 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
J Exp Med 200:783-95. 2004..These findings suggest that signals from lymphocytes induce FRCs to form the network that supports the movement and interactions of immune effectors within the lymph node... - Reduced GRK2 level in T cells potentiates chemotaxis and signaling in response to CCL4Anne Vroon
Laboratory for Psychoneuroimmunology, University Medical Center Utrecht, The Netherlands
J Leukoc Biol 75:901-9. 2004..whether reduced GRK2 expression changes the chemotactic response of T cells to the chemokines CCL3, CCL4, and CCL5. Activated T cells from GRK2+/- mice, which have a 50% reduction in GRK2 protein levels, showed a significant 40% .. - A dual role for tumor-derived chemokine RANTES (CCL5)Evan P Adler
Department of Biology, Lafayette College, Easton, PA 18042, USA
Immunol Lett 90:187-94. 2003To investigate the role of tumor-derived CCL5 (regulated upon activation, normal T cell expressed and secreted, RANTES) in tumor immunity we compared the T cell response to tumors derived from the 4T1 murine mammary carcinoma cell line .. - Cloning, genomic organization, and chromosomal localization of the Scya5 gene encoding the murine chemokine RANTEST M Danoff
Penn Center for Molecular Studies of Kidney Diseases, University of Pennsylvania, Philadelphia 19104
J Immunol 152:1182-9. 1994..regulation of RANTES, we have determined the genomic organization of the gene encoding the small inducible cytokine A5 (Scya5) and performed an initial analysis of its promoter elements... - Role of macrophages and colony-stimulating factor-1 in murine antiglomerular basement membrane glomerulonephritisJ Neugarten
Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
J Am Soc Nephrol 5:1903-9. 1995..macrophage-related cytokines, colony stimulating factor-1 (CSF-1), monocyte chemoattractant protein-1 (MCP-1) and RANTES, accelerated anti-GBM nephritis was studied in op/op mutant mice, which lack CSF-1 and are severely macrophage .. - Immunoregulatory role of ocular macrophages: the macrophages produce RANTES to suppress experimental autoimmune uveitisKoh Hei Sonoda
Department of Ophthalmology, Graduate School of Medical Science, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
J Immunol 171:2652-9. 2003..We found that only the macrophage-enriched cells from the eye produced RANTES, and thus proposed that macrophage-derived RANTES facilitated the ocular inflammations... - The role of macrophages in the disappearance of Meckel's cartilage during mandibular development in miceFumihiro Tsuzurahara
Department of Oral Anatomy and Developmental Biology, Showa University School of Dentistry, 1 5 8 Hatanodai, Shinagawa ku, Tokyo, Japan
Acta Histochem 113:194-200. 2011.... - Molecular characterization of two murine eosinophil beta chemokine receptorsT W Post
Department of Medicine, Brigham and Women s Hospital, Beth Israel Hospital, Boston, MA, USA
J Immunol 155:5299-305. 1995beta or C-C chemokines including RANTES, MCP-3, MIP-1 alpha, and eotaxin have been implicated in the pathogenesis of eosinophilic inflammation... - Molecular cloning and functional characterization of a novel member of the C-C chemokine familyT Hara
DNAX Research Institute of Molecular and Cellular Biology, Palo Alto 94304, USA
J Immunol 155:5352-8. 1995..These results clearly indicate that CCF18 is a new member of the C-C chemokine family. Since a high level of CCF18 mRNA is constitutively expressed in macrophage and myeloid cell lines, CCF18 may play a role in inflammatory processes... - Molecular cloning and expression of the murine RANTES cytokine: structural and functional conservation between mouse and manT J Schall
Department of Immunology, Genentech, South San Francisco, CA 94080
Eur J Immunol 22:1477-81. 1992..We report here on the molecular cloning, characterization, and functional expression of mu RANTES, a new murine member of this family... - Alveolar epithelial cells direct monocyte transepithelial migration upon influenza virus infection: impact of chemokines and adhesion moleculesSusanne Herold
University of Giessen Lung Center, Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine and Infectious Diseases, Justus Liebig University, Giessen, Germany
J Immunol 177:1817-24. 2006..the mouse-adapted influenza A virus strain PR/8 strongly induced the release of monocyte chemoattractants CCL2 and CCL5 followed by a strong monocyte transepithelial migration, and this monocytic response was strictly dependent on .. - Role of CCL5 (RANTES) in viral lung diseaseFiona J Culley
Department of Respiratory Medicine, National Heart and Lung Institute, Imperial College London, St Mary s Campus, Norfolk Place, London W2 1PG, United Kingdom
J Virol 80:8151-7. 2006CCL5/RANTES is a key proinflammatory chemokine produced by virus-infected epithelial cells and present in respiratory secretions of asthmatics... - Characterization of lipopolysaccharide responsive proteins that binds to the 5'-flanking regions of mouse RantesYoun Uck Kim
Division of Applied Biological Sciences, SunMoon University, Asan, Korea
Mol Cells 13:91-8. 2002..with lipopolysaccharide (LPS), factors that bind specifically to the LPS responsive element (LRE) of murine Rantes gene appeared in the nucleus... - Monocyte chemoattractant protein 1, macrophage inflammatory protein 1 alpha, and RANTES recruit macrophages to the kidney in a mouse model of hemolytic-uremic syndromeTiffany R Keepers
Division of Nephrology, University of Virginia, Box 800133, 1 Lane Road OMS 5815, Charlottesville, VA 22903, USA
Infect Immun 75:1229-36. 2007..monocyte chemoattractant protein 1 (MCP-1/CCL2), macrophage inflammatory protein 1alpha (MIP-1alpha/CCL3), and RANTES (CCL5), in a pattern that was coincident with macrophage infiltration as indicated by immunohistochemistry, .. - Maintenance of CCL5 mRNA stores by post-effector and memory CD8 T cells is dependent on transcription and is coupled to increased mRNA stabilityAntoine Marcais
INSERM, U503, Lyon, France
Eur J Immunol 36:2745-54. 2006..The storage of untranslated mRNA coding for the CCL5 chemokine by CD8 memory cells is a new process supporting the immediate display of an effector function... - Deposition of platelet RANTES triggering monocyte recruitment requires P-selectin and is involved in neointima formation after arterial injuryAndreas Schober
Department of Molecular Cardiovascular Research and Cardiology, Rheinisch Westfälische Technische Hochschule Aachen, Germany
Circulation 106:1523-9. 2002.... - Heritability of the maternal meiotic drive system linked to Om and high-resolution mapping of the Responder locus in mouseF Pardo-Manuel de Villena
Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
Genetics 155:283-9. 2000..In addition, analysis of the inheritance of alleles at Om among the offspring of F(1) intercrosses indicates that the effect of the sire is determined by the sperm genotype at Om or a locus linked to Om... - Regulatory context is a crucial part of gene functionSabine Fessele
Medizinische Poliklinik der Ludwig Maximilians Universität München, Schillerstr 42, D 80336, Munich, Germany
Trends Genet 18:60-3. 2002..Using the human RANTES/CCL5 promoter, we show that organizational features of promoters derived from promoter sequences contain .. - Hmgi-c-independent Activation of MuRantes in VivoJohn F Schiltz
Department of Biochemistry, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
Cell Growth Differ 13:39-45. 2002..from macrophage cell lines has previously suggested that Hmgi-c is necessary for the inducible activation of MuRantes expression...