Ccl24

Summary

Gene Symbol: Ccl24
Description: chemokine (C-C motif) ligand 24
Alias: CKb-6, MPIF-2, Scya24, C-C motif chemokine 24, CC chemokine CCL24, eosinophil chemotactic protein 2, eotaxin-2, small-inducible cytokine A24
Species: mouse
Products:     Ccl24

Top Publications

  1. Pope S, Zimmermann N, Stringer K, Karow M, Rothenberg M. The eotaxin chemokines and CCR3 are fundamental regulators of allergen-induced pulmonary eosinophilia. J Immunol. 2005;175:5341-50 pubmed
    ..These results imply that successful blockade of Ag-induced pulmonary eosinophilia will require antagonism of multiple CCR3 ligands. ..
  2. Fulkerson P, Fischetti C, McBride M, Hassman L, Hogan S, Rothenberg M. A central regulatory role for eosinophils and the eotaxin/CCR3 axis in chronic experimental allergic airway inflammation. Proc Natl Acad Sci U S A. 2006;103:16418-23 pubmed
    ..In summary, we present multiple lines of independent evidence that eosinophils via CCR3 have a central role in chronic allergic airway disease. ..
  3. Neilsen C, Bryce P. Interleukin-13 directly promotes oesophagus production of CCL11 and CCL24 and the migration of eosinophils. Clin Exp Allergy. 2010;40:427-34 pubmed publisher
    ..These were treated in vitro with IL-4 or IL-13 and the expression and production of CCL11 and CCL24 were determined...
  4. Munitz A, Brandt E, Mingler M, Finkelman F, Rothenberg M. Distinct roles for IL-13 and IL-4 via IL-13 receptor alpha1 and the type II IL-4 receptor in asthma pathogenesis. Proc Natl Acad Sci U S A. 2008;105:7240-5 pubmed publisher
    ..Taken together, our data provide a comprehensive mechanistic analysis of the critical role by which IL-13Ralpha1 mediates allergic lung pathology and highlight unforeseen roles for the type II IL-4R. ..
  5. Kurowska Stolarska M, Stolarski B, Kewin P, Murphy G, Corrigan C, Ying S, et al. IL-33 amplifies the polarization of alternatively activated macrophages that contribute to airway inflammation. J Immunol. 2009;183:6469-77 pubmed publisher
    ..macrophages toward an AAM phenotype that expressed mannose receptor, IL-4Ralpha, and produced high levels of CCL24 and CCL17 in an IL-13-dependent manner during IL-33-induced airway inflammation...
  6. Kannan Y, Entwistle L, Pelly V, Perez Lloret J, Walker A, Ley S, et al. TPL-2 restricts Ccl24-dependent immunity to Heligmosomoides polygyrus. PLoS Pathog. 2017;13:e1006536 pubmed publisher
    ..mice identified elevated expression of genes involved in chemotaxis and homing of leukocytes and cells, including Ccl24 and alternatively activated genes...
  7. Makita N, Hizukuri Y, Yamashiro K, Murakawa M, Hayashi Y. IL-10 enhances the phenotype of M2 macrophages induced by IL-4 and confers the ability to increase eosinophil migration. Int Immunol. 2015;27:131-41 pubmed publisher
    ..Moreover, IL-4 and IL-10 synergistically induced CCL24 (Eotaxin-2) production...
  8. Rajavelu P, Rayapudi M, Moffitt M, Mishra A, Mishra A. Significance of para-esophageal lymph nodes in food or aeroallergen-induced iNKT cell-mediated experimental eosinophilic esophagitis. Am J Physiol Gastrointest Liver Physiol. 2012;302:G645-54 pubmed publisher
    ..Thus we provide evidence that para-esophageal lymph nodes are involved in food- or aeroallergen-induced eosinophilia and patchy EoE pathogenesis, likely a mechanism dependent on eotaxins and iNKT cells...
  9. Takeda A, Baffi J, Kleinman M, Cho W, Nozaki M, Yamada K, et al. CCR3 is a target for age-related macular degeneration diagnosis and therapy. Nature. 2009;460:225-30 pubmed publisher
    ..CCR3 targeting might reduce vision loss due to AMD through early detection and therapeutic angioinhibition. ..

More Information

Publications21

  1. Ahrens R, Waddell A, Seidu L, Blanchard C, Carey R, Forbes E, et al. Intestinal macrophage/epithelial cell-derived CCL11/eotaxin-1 mediates eosinophil recruitment and function in pediatric ulcerative colitis. J Immunol. 2008;181:7390-9 pubmed
    ..have demonstrated a link between the eosinophil-selective chemokines, eotaxins (eotaxin-1/CCL11 and eotaxin-2/CCL24), eosinophils, and the inflammatory bowel diseases, Crohn's disease and ulcerative colitis (UC)...
  2. Duchesnes C, Murphy P, Williams T, Pease J. Alanine scanning mutagenesis of the chemokine receptor CCR3 reveals distinct extracellular residues involved in recognition of the eotaxin family of chemokines. Mol Immunol. 2006;43:1221-31 pubmed
    Despite considerable differences in primary structure, the chemokines eotaxin-1/CCL11, eotaxin-2/CCL24 and eotaxin-3/CCL26 signal via a single receptor, CCR3, but exhibit different potencies and efficacies...
  3. Siddiqui S, Secor E, Silbart L. Broncho-alveolar macrophages express chemokines associated with leukocyte migration in a mouse model of asthma. Cell Immunol. 2013;281:159-69 pubmed publisher
    ..b>Eotaxin 2 (CCL-24), which is known to influence eosinophil migration, was highly up-regulated in BAMs, but not Eotaxin-1 (..
  4. Dai C, Yao X, Gordon E, Barochia A, Cuento R, Kaler M, et al. A CCL24-dependent pathway augments eosinophilic airway inflammation in house dust mite-challenged Cd163(-/-) mice. Mucosal Immunol. 2016;9:702-17 pubmed publisher
    ..The increased airway eosinophils and MCM in HDM-challenged Cd163(-/-) mice were mediated by augmented CCL24 production and could be reversed by administration of a neutralizing anti-CCL24 antibody...
  5. Ben Yehuda C, Bader R, Puxeddu I, Levi Schaffer F, Breuer R, Berkman N. Airway eosinophil accumulation and eotaxin-2/CCL24 expression following allergen challenge in BALB/c mice. Exp Lung Res. 2008;34:467-79 pubmed publisher
    ..In order to clarify whether eotaxin-2/CCL24 accounts for prolonged airway eosinophilia, the authors determined the expression of CCL11 and CCL24 in lung ..
  6. Schulze J, Bickert T, Beil F, Zaiss M, Albers J, Wintges K, et al. Interleukin-33 is expressed in differentiated osteoblasts and blocks osteoclast formation from bone marrow precursor cells. J Bone Miner Res. 2011;26:704-17 pubmed publisher
    ..Taken together, these findings have uncovered a previously unknown function of IL-33 as an inhibitor of bone resorption. ..
  7. Fulkerson P, Fischetti C, Rothenberg M. Eosinophils and CCR3 regulate interleukin-13 transgene-induced pulmonary remodeling. Am J Pathol. 2006;169:2117-26 pubmed
    ..Taken together, these data definitively identify a functional contribution by eosinophils on the effects of chronic IL-13 expression in the lung. ..
  8. Kannan Y, Li Y, Coomes S, Okoye I, Pelly V, Sriskantharajah S, et al. Tumor progression locus 2 reduces severe allergic airway inflammation by inhibiting Ccl24 production in dendritic cells. J Allergy Clin Immunol. 2017;139:655-666.e7 pubmed publisher
    ..ELISA was used to assess the production of IgE, type 2 cytokines, and Ccl24. RNA sequencing was used to characterize dendritic cell (DC) transcripts...
  9. Wilson G, Hewit K, Pallas K, Cairney C, Lee K, Hansell C, et al. Atypical chemokine receptor ACKR2 controls branching morphogenesis in the developing mammary gland. Development. 2017;144:74-82 pubmed publisher
    ..These data demonstrate that ACKR2 is an important regulator of branching morphogenesis in diverse biological contexts and provide the first evidence of a role for chemokines and their receptors in postnatal development processes. ..
  10. Zimmermann N, Hogan S, Mishra A, Brandt E, Bodette T, Pope S, et al. Murine eotaxin-2: a constitutive eosinophil chemokine induced by allergen challenge and IL-4 overexpression. J Immunol. 2000;165:5839-46 pubmed
    ..Thus, murine eotaxin-2 is a constitutively expressed eosinophil chemokine likely to be involved in homeostatic, allergen-induced, and IL-4-associated immune responses. ..
  11. Beal D, Stepien D, Natarajan S, Kim J, Remick D. Reduction of eotaxin production and eosinophil recruitment by pulmonary autologous macrophage transfer in a cockroach allergen-induced asthma model. Am J Physiol Lung Cell Mol Physiol. 2013;305:L866-77 pubmed publisher
    ..undetectable; eotaxin 2: 2,383 vs. 131 pg/ml) and lung homogenate (eotaxin 1: 1,043 vs. 218 pg/ml; eotaxin 2: 10 vs. 1.5 ng/ml)...
  12. Pope S, Fulkerson P, Blanchard C, Akei H, Nikolaidis N, Zimmermann N, et al. Identification of a cooperative mechanism involving interleukin-13 and eotaxin-2 in experimental allergic lung inflammation. J Biol Chem. 2005;280:13952-61 pubmed
    ..Taken together, these results demonstrate a cooperative mechanism between IL-13 and eotaxin-2. In particular, IL-13 mediates allergen-induced eotaxin-2 expression, and eotaxin-2 mediates IL-13-induced airway eosinophilia. ..