Gene Symbol: Ccl22
Description: chemokine (C-C motif) ligand 22
Alias: ABCD-1, DCBCK, MDC, Scya22, C-C motif chemokine 22, CC chemokine ABCD-1, SMALL INDUCIBLE CYTOKINE A22 PRECURSOR (CC CHEMOKINE ABCD-1) (ACTIVATED B AND DENDRITIC CELL-DERIVED), activated B and dendritic cell-derived, dendritic cell and B cell derived chemokine, small inducible cytokine subfamily A, member 22, small inducible cytokine subfamily A22, small-inducible cytokine A22
Species: mouse
Products:     Ccl22

Top Publications

  1. Kawamoto N, Ohnishi H, Kondo N, Strominger J. The role of dendritic cells in the generation of CD4(+) CD25(HI) Foxp3(+) T cells induced by amino acid copolymers. Int Immunol. 2013;25:53-65 pubmed publisher
    ..The latter were the major splenic cell type that secreted CCL22 (macrophage-derived chemokine) on stimulation with amino acid copolymers...
  2. Guo Z, Jang M, Otani K, Bai Z, Umemoto E, Matsumoto M, et al. CD4+CD25+ regulatory T cells in the small intestinal lamina propria show an effector/memory phenotype. Int Immunol. 2008;20:307-15 pubmed publisher
    ..they showed efficient chemotaxis to the CCR4 ligands, CCL17/thymus and activation-regulated chemokine and CCL22/macrophage-derived chemokine, which are abundantly expressed by dendritic cells (DCs) in the small intestinal LP...
  3. Gonzalo J, Pan Y, Lloyd C, Jia G, Yu G, Dussault B, et al. Mouse monocyte-derived chemokine is involved in airway hyperreactivity and lung inflammation. J Immunol. 1999;163:403-11 pubmed
    The cloning, expression, and function of the murine (m) homologue of human (h) monocyte-derived chemokine (MDC) is reported here. Like hMDC, mMDC is able to elicit the chemotactic migration in vitro of activated lymphocytes and monocytes...
  4. Wang D, Li Q, Yang Y, Hao S, Han X, Song J, et al. Macrophage Subset Expressing CD169 in Peritoneal Cavity-Regulated Mucosal Inflammation Together with Lower Levels of CCL22. Inflammation. 2017;40:1191-1203 pubmed publisher
    ..results firstly showed that the subset of peritoneal CD11b+CD169+ macrophages increased and CCL22 expression level decreased significantly during the DSS-induced colitis...
  5. de Valle E, Grigoriadis G, O Reilly L, Willis S, Maxwell M, Corcoran L, et al. NF?B1 is essential to prevent the development of multiorgan autoimmunity by limiting IL-6 production in follicular B cells. J Exp Med. 2016;213:621-41 pubmed publisher
    ..Collectively, our findings identify a previously unrecognized role for NF?B1 in preventing multiorgan autoimmunity through its negative regulation of Il-6 gene expression in Fo B cells. ..
  6. Bleul C, Boehm T. Chemokines define distinct microenvironments in the developing thymus. Eur J Immunol. 2000;30:3371-9 pubmed
    ..temporally during embryogenesis; in the alymphoid early thymic anlage, only TECK, SDF-1 and SLC but not ELC, MDC or TARC are expressed...
  7. Han X, Wang C, Qiao H, Zhang Y, Chang Y, Zhang Y. [Mouse macrophage-derived chemokine as an adjuvant enhances the protective effect of P6 protein vaccine of nontypeable Haemophilus influenzae]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2014;30:913-6 pubmed
    ..Haemophilus influenzae (NTHi) in prokaryotic cells and observe the immune effect of macrophage-derived chemokine (MDC) as an adjuvant on NTHi-P6 protein vaccine...
  8. Kusumoto M, Xu B, Shi M, Matsuyama T, Aoyama K, Takeuchi T. Expression of chemokine receptor CCR4 and its ligands (CCL17 and CCL22) in murine contact hypersensitivity. J Interferon Cytokine Res. 2007;27:901-10 pubmed
    Chemokine receptor CCR4 and its ligands (CCL17 and CCL22) are important for the recruitment of memory T cells into the skin in various cutaneous immune diseases...
  9. Briot A, Deraison C, Lacroix M, Bonnart C, Robin A, Besson C, et al. Kallikrein 5 induces atopic dermatitis-like lesions through PAR2-mediated thymic stromal lymphopoietin expression in Netherton syndrome. J Exp Med. 2009;206:1135-47 pubmed publisher
    ..They illustrate the crucial role of protease signaling in skin inflammation and point to new therapeutic targets for NS as well as candidate genes for AD and atopy. ..

More Information


  1. Osborn O, Sanchez Alavez M, Dubins J, Gonzalez A, Morrison B, Hadcock J, et al. Ccl22/MDC, is a prostaglandin dependent pyrogen, acting in the anterior hypothalamus to induce hyperthermia via activation of brown adipose tissue. Cytokine. 2011;53:311-9 pubmed publisher
    CC Chemokine ligand 22 (Ccl22) is a selective, high affinity ligand at the CC chemokine receptor 4 (Ccr4)...
  2. Furudate S, Fujimura T, Kambayashi Y, Kakizaki A, Hidaka T, Aiba S. Immunomodulatory Effect of Imiquimod Through CCL22 Produced by Tumor-associated Macrophages in B16F10 Melanomas. Anticancer Res. 2017;37:3461-3471 pubmed
    ..with reduction of Foxp3+ regulatory T cells (Tregs) at the tumor site, caused by the down-regulation of CCL22 production by tumor-derived and splenic CD11b+ cells...
  3. Montane J, Bischoff L, Soukhatcheva G, Dai D, Hardenberg G, Levings M, et al. Prevention of murine autoimmune diabetes by CCL22-mediated Treg recruitment to the pancreatic islets. J Clin Invest. 2011;121:3024-8 pubmed publisher
    ..regulate immune responses by suppressing effector T cells and are recruited to sites of action by the chemokine CCL22. Here, we demonstrate that production of CCL22 in islets after intrapancreatic duct injection of double-stranded ..
  4. Laan M, Kisand K, Kont V, Möll K, Tserel L, Scott H, et al. Autoimmune regulator deficiency results in decreased expression of CCR4 and CCR7 ligands and in delayed migration of CD4+ thymocytes. J Immunol. 2009;183:7682-91 pubmed publisher
    ..These results suggest a novel mechanism behind the Aire-dependent induction of central tolerance. ..
  5. Onodera T, Jang M, Guo Z, Yamasaki M, Hirata T, Bai Z, et al. Constitutive expression of IDO by dendritic cells of mesenteric lymph nodes: functional involvement of the CTLA-4/B7 and CCL22/CCR4 interactions. J Immunol. 2009;183:5608-14 pubmed publisher
    ..We also found that the MLN DCs produced CCL22, which can attract Tregs via CCR4, and that the phagocytosis of autologous apoptotic cells induced CCL22 ..
  6. Ross R, Ross X, Ghadially H, Lahr T, Schwing J, Knop J, et al. Mouse langerhans cells differentially express an activated T cell-attracting CC chemokine. J Invest Dermatol. 1999;113:991-8 pubmed
    ..Thus, production of this chemokine by dendritic cells may be essential for the establishment and amplification of T cell responses. ..
  7. Santulli Marotto S, Wheeler J, Lacy E, Boakye K, Luongo J, Wu S, et al. CCL22-specific Antibodies Reveal That Engagement of Two Distinct Binding Domains on CCL22 Is Required for CCR4-mediated Function. Monoclon Antib Immunodiagn Immunother. 2015;34:373-80 pubmed publisher
    b>CCL22 inactivation in vivo occurs by cleavage at the N-terminus; however, it is unclear whether this encompasses the entire site of CCR4 interaction. CCL17 also binds CCR4 and its function requires binding via two discrete binding sites...
  8. Glowacki A, Yoshizawa S, Jhunjhunwala S, Vieira A, Garlet G, Sfeir C, et al. Prevention of inflammation-mediated bone loss in murine and canine periodontal disease via recruitment of regulatory lymphocytes. Proc Natl Acad Sci U S A. 2013;110:18525-30 pubmed publisher
    ..generating a steady release of a known chemoattractant for regulatory lymphocytes, C-C motif chemokine ligand 22 (CCL22), composed of a degradable polymer with a proven track record of clinical translation, poly(lactic-co-glycolic) ..
  9. Lee K, Danuser R, Stein J, Graham D, Nibbs R, Graham G. The chemokine receptors ACKR2 and CCR2 reciprocally regulate lymphatic vessel density. EMBO J. 2014;33:2564-80 pubmed publisher
    ..Therefore, these receptors regulate vessel density by reciprocally modulating pro-lymphangiogenic macrophage recruitment, and proximity, to developing, resting and regenerating lymphatic vessels. ..
  10. Watanabe M, Satoh T, Yamamoto Y, Kanai Y, Karasuyama H, Yokozeki H. Overproduction of IgE induces macrophage-derived chemokine (CCL22) secretion from basophils. J Immunol. 2008;181:5653-9 pubmed
    Macrophage-derived chemokine (MDC) CCL22 is a potent chemoattractant for Th2 cells and has been implicated in Th2-predominant allergic inflammation...
  11. Mailloux A, Young M. NK-dependent increases in CCL22 secretion selectively recruits regulatory T cells to the tumor microenvironment. J Immunol. 2009;182:2753-65 pubmed publisher
    ..LLC-bearing lungs secreted elevated levels of the CCR4-associated chemokine CCL22 compared with normal lungs...
  12. Yan D, Wang H, Bowman R, Joyce J. STAT3 and STAT6 Signaling Pathways Synergize to Promote Cathepsin Secretion from Macrophages via IRE1? Activation. Cell Rep. 2016;16:2914-2927 pubmed publisher
    ..Together, these findings demonstrate that cytokine-activated STAT3 and STAT6 cooperate in macrophages to promote a secretory phenotype that enhances tumor progression in a cathepsin-dependent manner. ..
  13. Poddar D, Basu A, Baldwin W, Kondratov R, Barik S, Mazumder B. An extraribosomal function of ribosomal protein L13a in macrophages resolves inflammation. J Immunol. 2013;190:3600-12 pubmed publisher
    ..Macrophages from these knockout animals show unregulated expression of several chemokines (e.g., CXCL13, CCL22, CCL8, and CCR3). These macrophages failed to show L13a-dependent RNA binding complex formation on target mRNAs...
  14. Kanazawa N, Nakamura T, Tashiro K, Muramatsu M, Morita K, Yoneda K, et al. Fractalkine and macrophage-derived chemokine: T cell-attracting chemokines expressed in T cell area dendritic cells. Eur J Immunol. 1999;29:1925-32 pubmed
    ..In this study we isolated mouse fractalkine and macrophage-derived chemokine (MDC) belonging to CX3C (delta) and CC chemokine families, respectively, from bone marrow-derived mature DC...
  15. Eby J, Kang H, Tully S, Bindeman W, Peiffer D, Chatterjee S, et al. CCL22 to Activate Treg Migration and Suppress Depigmentation in Vitiligo. J Invest Dermatol. 2015;135:1574-1580 pubmed publisher
    ..Thus, we sought a means to repopulate patient skin with Tregs. We hypothesized that enhanced expression of CCL22 can promote Treg skin homing to suppress depigmentation...
  16. Cao L, Hu X, Zhang J, Huang G, Zhang Y. The role of the CCL22-CCR4 axis in the metastasis of gastric cancer cells into omental milky spots. J Transl Med. 2014;12:267 pubmed publisher
    ..This study investigated the role of the CCL22-CCR4 axis in gastric cancer cells selectively infiltrating into milky spots...
  17. Ghadially H, Ross X, Kerst C, Dong J, Reske Kunz A, Ross R. Differential regulation of CCL22 gene expression in murine dendritic cells and B cells. J Immunol. 2005;174:5620-9 pubmed
    The activated T cell-attracting CC chemokine CCL22 is expressed by stimulated B cells and mature dendritic cells (DC)...
  18. Nakamura E, Koizumi K, Kobayashi M, Saitoh Y, Arita Y, Nakayama T, et al. RANKL-induced CCL22/macrophage-derived chemokine produced from osteoclasts potentially promotes the bone metastasis of lung cancer expressing its receptor CCR4. Clin Exp Metastasis. 2006;23:9-18 pubmed
    ..Here we report that differentiating osteoclasts constitutively produce CCL22 (also called macrophage-derived chemokine) and potentially promote bone metastasis of lung cancer expressing its ..
  19. Pinho V, Oliveira S, Souza D, Vasconcelos D, Alessandri A, Lukacs N, et al. The role of CCL22 (MDC) for the recruitment of eosinophils during allergic pleurisy in mice. J Leukoc Biol. 2003;73:356-62 pubmed
    ..In the present study, we have investigated the effects of CCL22 on the recruitment of eosinophils in vivo and in vitro...
  20. Araujo Pires A, Vieira A, Francisconi C, Biguetti C, Glowacki A, Yoshizawa S, et al. IL-4/CCL22/CCR4 axis controls regulatory T-cell migration that suppresses inflammatory bone loss in murine experimental periodontitis. J Bone Miner Res. 2015;30:412-22 pubmed publisher
    ..The blockade of the CCR4 ligand CCL22 in WT mice resulted in an increased inflammatory bone loss phenotype similar to that in the CCR4KO strain...
  21. Hao S, Han X, Wang D, Yang Y, Li Q, Li X, et al. Critical role of CCL22/CCR4 axis in the maintenance of immune homeostasis during apoptotic cell clearance by splenic CD8α(+) CD103(+) dendritic cells. Immunology. 2016;148:174-86 pubmed publisher
    ..Here, we found that the CCL22/CCR4 axis played a critical role in the maintenance of immune homeostasis during apoptotic cell clearance by ..
  22. Schaniel C, Pardali E, Sallusto F, Speletas M, Ruedl C, Shimizu T, et al. Activated murine B lymphocytes and dendritic cells produce a novel CC chemokine which acts selectively on activated T cells. J Exp Med. 1998;188:451-63 pubmed
    ..Therefore, ABCD-1 is expected to play an important role in the collaboration of dendritic cells and B lymphocytes with T cells in immune responses. ..
  23. Chantry D, Romagnani P, Raport C, Wood C, Epp A, Romagnani S, et al. Macrophage-derived chemokine is localized to thymic medullary epithelial cells and is a chemoattractant for CD3(+), CD4(+), CD8(low) thymocytes. Blood. 1999;94:1890-8 pubmed
    Macrophage-derived chemokine (MDC) is a recently identified CC chemokine that is a potent chemoattractant for dendritic cells, natural killer (NK) cells, and the Th2 subset of peripheral blood T cells...
  24. Richter J, Sutton J, Belizaire R, Friend L, Schuster R, Johannigman T, et al. Macrophage-derived chemokine (CCL22) is a novel mediator of lung inflammation following hemorrhage and resuscitation. Shock. 2014;42:525-31 pubmed publisher
    ..Our previous data indicate that macrophage-derived chemokine (MDC/CCL22) is elevated after resuscitation, but its direct role in this inflammatory response is unknown...
  25. Fu G, Wijburg O, Cameron P, Price J, Strugnell R. Salmonella enterica Serovar Typhimurium infection of dendritic cells leads to functionally increased expression of the macrophage-derived chemokine. Infect Immun. 2005;73:1714-22 pubmed
    ..cells revealed a number of differentially expressed transcripts, which included the macrophage-derived chemokine (MDC)...
  26. Bischoff L, Alvarez S, Dai D, Soukhatcheva G, Orban P, Verchere C. Cellular mechanisms of CCL22-mediated attenuation of autoimmune diabetes. J Immunol. 2015;194:3054-64 pubmed publisher
    ..We have reported that expression of the chemokine CCL22 in pancreatic β cells in the NOD mouse prevents autoimmune attack by recruiting T regulatory cells (Tregs), ..
  27. Rapp M, Grassmann S, Chaloupka M, Layritz P, Krüger S, Ormanns S, et al. C-C chemokine receptor type-4 transduction of T cells enhances interaction with dendritic cells, tumor infiltration and therapeutic efficacy of adoptive T cell transfer. Oncoimmunology. 2016;5:e1105428 pubmed
    ..The chemokine C-C motif ligand 22 (CCL22) is highly expressed by immune cells in murine and human pancreatic cancer...
  28. Dogan R, Long N, Forde E, Dennis K, Kohm A, Miller S, et al. CCL22 regulates experimental autoimmune encephalomyelitis by controlling inflammatory macrophage accumulation and effector function. J Leukoc Biol. 2011;89:93-104 pubmed publisher
    EAE is a demyelinating disease of the CNS and serves as a mouse model of MS. Expression of CCL22 in the draining LNs and spinal cord correlated with the onset of clinical EAE development and remained elevated...