CCL2

Summary

Gene Symbol: CCL2
Description: chemokine (C-C motif) ligand 2
Alias: AI323594, HC11, MCAF, MCP-1, MCP1, SMC-CF, Scya2, Sigje, C-C motif chemokine 2, monocyte chemoattractant protein 1, monocyte chemotactic protein 1, platelet-derived growth factor-inducible protein JE, small-inducible cytokine A2
Species: mouse
Products:     CCL2

Top Publications

  1. Clarke M, Talib S, Figg N, Bennett M. Vascular smooth muscle cell apoptosis induces interleukin-1-directed inflammation: effects of hyperlipidemia-mediated inhibition of phagocytosis. Circ Res. 2010;106:363-72 pubmed publisher
    ..Thus, failed clearance of apoptotic VSMCs caused by hyperlipidemia in vivo may promote the increased serum cytokines and chronic inflammation associated with atherosclerosis. ..
  2. Chen M, Hombrebueno J, Luo C, Penalva R, Zhao J, Colhoun L, et al. Age- and light-dependent development of localised retinal atrophy in CCL2(-/-)CX3CR1(GFP/GFP) mice. PLoS ONE. 2013;8:e61381 pubmed publisher
    Previous studies have shown that CCL2/CX3CR1 deficient mice on C57BL/6N background (with rd8 mutation) have an early onset (6 weeks) of spontaneous retinal degeneration...
  3. Cao X, Liu M, Tuo J, Shen D, Chan C. The effects of quercetin in cultured human RPE cells under oxidative stress and in Ccl2/Cx3cr1 double deficient mice. Exp Eye Res. 2010;91:15-25 pubmed publisher
    ..This study investigates the mechanisms for the effects of quercetin on cultured human RPE cells and in Ccl2/Cx3cr1 double knock-out (DKO) mice, which spontaneously develop progressive retinal lesions mimicking age-related ..
  4. Chen M, Zhao J, Luo C, Pandi S, Peñalva R, Fitzgerald D, et al. Para-inflammation-mediated retinal recruitment of bone marrow-derived myeloid cells following whole-body irradiation is CCL2 dependent. Glia. 2012;60:833-42 pubmed publisher
    ..by a low-grade chronic inflammation, para-inflammation, characterized by upregulated expression of chemokines (CCL2, CXCL12, and CX3CL1) and complement components (C4 and CFH), and microglial activation...
  5. Arendt L, McCready J, Keller P, Baker D, Naber S, Seewaldt V, et al. Obesity promotes breast cancer by CCL2-mediated macrophage recruitment and angiogenesis. Cancer Res. 2013;73:6080-93 pubmed publisher
    ..within human and mouse breast tissues recruit and activate macrophages through a previously uncharacterized CCL2/IL-1?/CXCL12 signaling pathway...
  6. Kiyota T, Yamamoto M, Xiong H, Lambert M, Klein W, Gendelman H, et al. CCL2 accelerates microglia-mediated Abeta oligomer formation and progression of neurocognitive dysfunction. PLoS ONE. 2009;4:e6197 pubmed publisher
    ..To this end, we previously demonstrated that transgenic over-expression of CCL2 enhanced microgliosis and induced diffuse amyloid plaque deposition in Tg2576 mice...
  7. Mandrekar P, Ambade A, Lim A, Szabo G, Catalano D. An essential role for monocyte chemoattractant protein-1 in alcoholic liver injury: regulation of proinflammatory cytokines and hepatic steatosis in mice. Hepatology. 2011;54:2185-97 pubmed publisher
    ..In vitro assays uncovered an inhibitory effect of recombinant MCP-1 on PPAR? messenger RNA and peroxisome proliferator response element binding in hepatocytes independent of CCR2...
  8. Hodge D, Reynolds D, Cerbán F, Correa S, Baez N, Young H, et al. MCP-1/CCR2 interactions direct migration of peripheral B and T lymphocytes to the thymus during acute infectious/inflammatory processes. Eur J Immunol. 2012;42:2644-54 pubmed publisher
    ..Finally, systemic expression of IL-12 and IL-18 produced during the inflammatory process is ultimately responsible for these migratory events. ..
  9. Godefroy D, Gosselin R, Yasutake A, Fujimura M, Combadiere C, Maury Brachet R, et al. The chemokine CCL2 protects against methylmercury neurotoxicity. Toxicol Sci. 2012;125:209-18 pubmed publisher
    ..diseases, we tested the possibility that the neurotoxic effect of MeHg may interfere with the chemokine CCL2. We have used an original protocol in young mice using a MeHg-contaminated fish-based diet for 3 months relevant to ..

More Information

Publications64

  1. Verma V, Sauer T, Chan C, Zhou M, Zhang C, Maminishkis A, et al. Constancy of ERp29 expression in cultured retinal pigment epithelial cells in the Ccl2/Cx3cr1 deficient mouse model of age-related macular degeneration. Curr Eye Res. 2008;33:701-7 pubmed publisher
    ..and the links drawn between chaperone proteins and neurodegenerative disease, we aimed to culture RPE from the Ccl2(-/-)/Cx3cr1(-/-) mouse model of AMD and evaluate expression of chaperone protein ERp29...
  2. Lu H, Huang D, Ransohoff R, Zhou L. Acute skeletal muscle injury: CCL2 expression by both monocytes and injured muscle is required for repair. FASEB J. 2011;25:3344-55 pubmed publisher
    CC chemokine ligand 2 (CCL2), a ligand of CC chemokine receptor 2 (CCR2), is essential to mount an adequate inflammatory response to repair acute skeletal muscle injury...
  3. Shen D, Cao X, Zhao L, Tuo J, Wong W, Chan C. Naloxone ameliorates retinal lesions in Ccl2/Cx3cr1 double-deficient mice via modulation of microglia. Invest Ophthalmol Vis Sci. 2011;52:2897-904 pubmed publisher
    ..The authors evaluated the effects of naloxone on Ccl2(-/-)/Cx3cr1(-/-) (DKO) mice, a murine model of age-related macular degeneration (AMD)...
  4. Rodríguez Sanabria F, Rull A, Beltran Debon R, Aragones G, Camps J, Mackness B, et al. Tissue distribution and expression of paraoxonases and chemokines in mouse: the ubiquitous and joint localisation suggest a systemic and coordinated role. J Mol Histol. 2010;41:379-86 pubmed publisher
    ..Using immunohistochemistry and quantitative real-time PCR we have investigated the distribution of PON1, 2 and 3, CCL2, 7, 8 and 12 and the chemokine receptor CCR2 protein and mRNA in 23 tissues from C57BL/6J mice...
  5. Boyle A, Yeghiazarians Y, Shih H, Hwang J, Ye J, Sievers R, et al. Myocardial production and release of MCP-1 and SDF-1 following myocardial infarction: differences between mice and man. J Transl Med. 2011;9:150 pubmed publisher
    ..However, for MCP-1 the animal model is the exact opposite of the human condition. Human observational studies like this one are paramount in guiding translation from experimental studies to clinical trials. ..
  6. Zhou Y, Sheets K, Knott E, Regan C, Tuo J, Chan C, et al. Cellular and 3D optical coherence tomography assessment during the initiation and progression of retinal degeneration in the Ccl2/Cx3cr1-deficient mouse. Exp Eye Res. 2011;93:636-48 pubmed publisher
    ..cells, drusen-like accumulation, photoreceptor atrophy, and choroidal neovascularization, have been reported in the Ccl2/Cx3cr1-deficient mouse...
  7. Li X, Loberg R, Liao J, Ying C, Snyder L, Pienta K, et al. A destructive cascade mediated by CCL2 facilitates prostate cancer growth in bone. Cancer Res. 2009;69:1685-92 pubmed publisher
    b>Monocyte chemoattractant protein 1 (CCL2) is a recently identified prominent regulator of prostate cancer growth and metastasis. The purpose of this study was to investigate the mechanistic role of CCL2 in prostate cancer growth in bone...
  8. Trujillo J, Fleming E, Perlman S. Transgenic CCL2 expression in the central nervous system results in a dysregulated immune response and enhanced lethality after coronavirus infection. J Virol. 2013;87:2376-89 pubmed publisher
    Chemokine (C-C motif) ligand 2 (CCL2), a chemoattractant for macrophages, T cells, and cells expressing CCR2, is upregulated during acute and chronic inflammation...
  9. Ramnath R, Ng S, Guglielmotti A, Bhatia M. Role of MCP-1 in endotoxemia and sepsis. Int Immunopharmacol. 2008;8:810-8 pubmed publisher
    ..Considering these results, we propose that anti-MCP-1 strategies may be of potential therapeutic value in the treatment of sepsis and endotoxemia. ..
  10. Dogan R, Elhofy A, Karpus W. Production of CCL2 by central nervous system cells regulates development of murine experimental autoimmune encephalomyelitis through the recruitment of TNF- and iNOS-expressing macrophages and myeloid dendritic cells. J Immunol. 2008;180:7376-84 pubmed
    ..Increased expression of the chemokine CCL2 in the CNS has been demonstrated to be important in the development of demyelinating disease presumably by ..
  11. Tuo J, Ross R, Herzlich A, Shen D, Ding X, Zhou M, et al. A high omega-3 fatty acid diet reduces retinal lesions in a murine model of macular degeneration. Am J Pathol. 2009;175:799-807 pubmed publisher
    ..In this study, we evaluated the effect of such a diet on the retinas of Ccl2(-/-)/Cx3cr1(-/-) mice, a model that develops AMD-like retinal lesions that include focal deep retinal lesions, ..
  12. Jimenez F, Quinones M, Martinez H, Estrada C, Clark K, Garavito E, et al. CCR2 plays a critical role in dendritic cell maturation: possible role of CCL2 and NF-kappa B. J Immunol. 2010;184:5571-81 pubmed publisher
    ..Supporting this notion, we found that CCR2, its ligand CCL2, and NF-kappaB were required for CCL19 production and adequate Langerhans cell (LC) migration both ex vivo and in ..
  13. Chen M, Forrester J, Xu H. Dysregulation in retinal para-inflammation and age-related retinal degeneration in CCL2 or CCR2 deficient mice. PLoS ONE. 2011;6:e22818 pubmed publisher
    ..In this study, we examined this hypothesis in mice deficient in chemokine CCL2 or its cognate receptor CCR2...
  14. Shi C, Jia T, Mendez Ferrer S, Hohl T, Serbina N, Lipuma L, et al. Bone marrow mesenchymal stem and progenitor cells induce monocyte emigration in response to circulating toll-like receptor ligands. Immunity. 2011;34:590-601 pubmed publisher
    ..their entry into the bloodstream requires stimulation of CCR2 chemokine receptor by monocyte chemotactic protein-1 (MCP1). How monocyte emigration from bone marrow is triggered by remote infections remains unclear...
  15. Eguchi K, Manabe I, Oishi Tanaka Y, Ohsugi M, Kono N, Ogata F, et al. Saturated fatty acid and TLR signaling link ? cell dysfunction and islet inflammation. Cell Metab. 2012;15:518-33 pubmed publisher
    ..Collectively, these results demonstrate a clear mechanistic link between ? cell dysfunction and inflammation mediated at least in part via the FFA-TLR4/MyD88 pathway. ..
  16. Tateya S, Tamori Y, Kawaguchi T, Kanda H, Kasuga M. An increase in the circulating concentration of monocyte chemoattractant protein-1 elicits systemic insulin resistance irrespective of adipose tissue inflammation in mice. Endocrinology. 2010;151:971-9 pubmed publisher
    ..These data indicate that an increase in the concentration of MCP-1 in the circulation is sufficient to induce systemic insulin resistance irrespective of adipose tissue inflammation. ..
  17. D Mello C, Le T, Swain M. Cerebral microglia recruit monocytes into the brain in response to tumor necrosis factoralpha signaling during peripheral organ inflammation. J Neurosci. 2009;29:2089-102 pubmed publisher
    ..Cerebral recruitment of monocytes was abolished in inflamed mice that lacked MCP-1/CCL2 or CCR2...
  18. Getts D, Terry R, Getts M, Müller M, Rana S, Shrestha B, et al. Ly6c+ "inflammatory monocytes" are microglial precursors recruited in a pathogenic manner in West Nile virus encephalitis. J Exp Med. 2008;205:2319-37 pubmed publisher
    ..b>CCL2 is a chemokine that is highly expressed during WNV infection and important in inflammatory monocyte trafficking...
  19. Izhak L, Wildbaum G, Zohar Y, Anunu R, Klapper L, Elkeles A, et al. A novel recombinant fusion protein encoding a 20-amino acid residue of the third extracellular (E3) domain of CCR2 neutralizes the biological activity of CCL2. J Immunol. 2009;183:732-9 pubmed publisher
    b>CCL2 is a key CC chemokine that has been implicated in a variety of inflammatory autoimmune diseases and in tumor progression and it is therefore an important target for therapeutic intervention in these diseases...
  20. Takahashi M, Galligan C, Tessarollo L, Yoshimura T. Monocyte chemoattractant protein-1 (MCP-1), not MCP-3, is the primary chemokine required for monocyte recruitment in mouse peritonitis induced with thioglycollate or zymosan A. J Immunol. 2009;183:3463-71 pubmed publisher
    MCP-1/CCL2 plays a critical role in monocyte recruitment into sites of immune responses and cancer. However, the role of other MCPs remains unclear...
  21. Qian B, Li J, Zhang H, Kitamura T, Zhang J, Campion L, et al. CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis. Nature. 2011;475:222-5 pubmed publisher
    ..The recruitment of these inflammatory monocytes, which express CCR2 (the receptor for chemokine CCL2), as well as the subsequent recruitment of metastasis-associated macrophages and their interaction with ..
  22. Iida K, Suzuki K, Yokota M, Nakagomi D, Wakashin H, Iwata A, et al. STAT4 is required for IFN-?-induced MCP-1 mRNA expression in murine mast cells. Int Arch Allergy Immunol. 2011;155 Suppl 1:71-6 pubmed publisher
    ..STAT4 plays an essential role in IFN-?-induced MCP-1 mRNA expression in mast cells. ..
  23. Wintges K, Beil F, Albers J, Jeschke A, Schweizer M, Claass B, et al. Impaired bone formation and increased osteoclastogenesis in mice lacking chemokine (C-C motif) ligand 5 (Ccl5). J Bone Miner Res. 2013;28:2070-80 pubmed publisher
    ..Because we have previously observed that chemokine (C-C motif) ligand 2 (Ccl2) and Ccl5 are direct target genes of noncanonical Wnt signaling in osteoblasts, we analyzed the skeletal phenotypes ..
  24. Yao Y, Tsirka S. Truncation of monocyte chemoattractant protein 1 by plasmin promotes blood-brain barrier disruption. J Cell Sci. 2011;124:1486-95 pubmed publisher
    Previous studies have shown that plasmin cleaves monocyte chemoattractant protein 1 (MCP1; officially known as C-C motif chemokine 2, CCL2) at K104, and this cleavage enhances its chemotactic potency significantly...
  25. Fridlender Z, Kapoor V, Buchlis G, Cheng G, Sun J, Wang L, et al. Monocyte chemoattractant protein-1 blockade inhibits lung cancer tumor growth by altering macrophage phenotype and activating CD8+ cells. Am J Respir Cell Mol Biol. 2011;44:230-7 pubmed publisher
    ..Monocyte chemoattractant protein-1 (MCP-1, also known as CCL2) is secreted from tumor cells and associated tumor stromal cells...
  26. Tang X, Yang Y, Amar S. Novel regulation of CCL2 gene expression by murine LITAF and STAT6B. PLoS ONE. 2011;6:e25083 pubmed publisher
    ..Furthermore, mLITAF was found to mediate LPS-induced CCL2 gene transcription with the cooperation of mSTAT6B leading to CCL2 protein expression...
  27. Joly S, Samardzija M, Wenzel A, Thiersch M, Grimm C. Nonessential role of beta3 and beta5 integrin subunits for efficient clearance of cellular debris after light-induced photoreceptor degeneration. Invest Ophthalmol Vis Sci. 2009;50:1423-32 pubmed publisher
    ..Wild-type, beta5(-/-) and beta3(-/-) single-knockout, and beta3(-/-)/beta5(-/-) Ccl2(-/-)/beta5(-/-) double-knockout mice were exposed to 13,000 lux of white light for 2 hours to induce severe ..
  28. Dunay I, DaMatta R, Fux B, Presti R, Greco S, Colonna M, et al. Gr1(+) inflammatory monocytes are required for mucosal resistance to the pathogen Toxoplasma gondii. Immunity. 2008;29:306-17 pubmed publisher
    ..Mice deficient of the chemokine receptor CCR2 or the ligand CCL2 failed to recruit Gr1(+) inflammatory monocytes, whereas dendritic cells and resident tissue macrophages remained ..
  29. Jia T, Serbina N, Brandl K, Zhong M, Leiner I, Charo I, et al. Additive roles for MCP-1 and MCP-3 in CCR2-mediated recruitment of inflammatory monocytes during Listeria monocytogenes infection. J Immunol. 2008;180:6846-53 pubmed
    ..Our data demonstrate that MCP-3 and MCP-1 provide parallel contributions to CCR2-mediated inflammatory monocyte recruitment and that both chemokines are required for optimal innate immune defense against L. monocytogenes infection. ..
  30. Dal Secco V, Soldani C, Debrat C, Asperti Boursin F, Donnadieu E, Viola A, et al. Tunable chemokine production by antigen presenting dendritic cells in response to changes in regulatory T cell frequency in mouse reactive lymph nodes. PLoS ONE. 2009;4:e7696 pubmed publisher
    ..We found that pro-inflammatory chemokines -- CCL2 (MCP-1) and CCL3 (MIP-la) -- are secreted in the LN early (24 h) after T cell activation, that this secretion is ..
  31. Vessey K, Greferath U, Jobling A, Phipps J, Ho T, Waugh M, et al. Ccl2/Cx3cr1 knockout mice have inner retinal dysfunction but are not an accelerated model of AMD. Invest Ophthalmol Vis Sci. 2012;53:7833-46 pubmed publisher
    The chemokine, Ccl2, and the fractalkine receptor, Cx3cr1, have both been implicated in the pathogenesis of age related macular degeneration (AMD), with mice lacking both genes exhibiting features of AMD by 3 months of age...
  32. Fridlender Z, Buchlis G, Kapoor V, Cheng G, Sun J, Singhal S, et al. CCL2 blockade augments cancer immunotherapy. Cancer Res. 2010;70:109-18 pubmed publisher
    ..Monocyte chemoattractant proteins (such as CCL2) are produced by many tumors and have both direct and indirect immunoinhibitory effects...
  33. Schilling M, Strecker J, Ringelstein E, Kiefer R, Schäbitz W. Turn-over of meningeal and perivascular macrophages in the brain of MCP-1-, CCR-2- or double knockout mice. Exp Neurol. 2009;219:583-5 pubmed publisher
    ..This finding emphasizes that the MCP-1/CCR2 axis is crucially important for macrophage turnover and compensatory mechanisms remain only partially sufficient to sustain regulatory functions. ..
  34. Strecker J, Minnerup J, Schütte Nütgen K, Gess B, Schäbitz W, Schilling M. Monocyte chemoattractant protein-1-deficiency results in altered blood-brain barrier breakdown after experimental stroke. Stroke. 2013;44:2536-44 pubmed publisher
    ..The results of the study provide further insights into the molecular mechanisms of BBB-opening and may help to better understand the mechanisms of infarct development after cerebral ischemia. ..
  35. Luhmann U, Lange C, Robbie S, Munro P, Cowing J, Armer H, et al. Differential modulation of retinal degeneration by Ccl2 and Cx3cr1 chemokine signalling. PLoS ONE. 2012;7:e35551 pubmed publisher
    ..Defining the role of Ccl2-Ccr2 and Cx3cl1-Cx3cr1 signalling for retinal pathology is of particular interest because of its potential role in ..
  36. Chan C, Ross R, Shen D, Ding X, Majumdar Z, Bojanowski C, et al. Ccl2/Cx3cr1-deficient mice: an animal model for age-related macular degeneration. Ophthalmic Res. 2008;40:124-8 pubmed publisher
    Senescent Ccl2-/- mice develop cardinal features of human age-related macular degeneration (AMD). Loss-of-function single-nucleotide polymorphisms within CX3CR1 are associated with AMD...
  37. Davies M, Stempel A, Powers M. MCP-1 deficiency delays regression of pathologic retinal neovascularization in a model of ischemic retinopathy. Invest Ophthalmol Vis Sci. 2008;49:4195-202 pubmed publisher
    ..These findings suggest that macrophages/microglia may contribute to tuft regression through their proapoptotic properties. ..
  38. Luhmann U, Robbie S, Munro P, Barker S, Duran Y, Luong V, et al. The drusenlike phenotype in aging Ccl2-knockout mice is caused by an accelerated accumulation of swollen autofluorescent subretinal macrophages. Invest Ophthalmol Vis Sci. 2009;50:5934-43 pubmed publisher
    ..b>Ccl2-knockout (Ccl2(-/-)) mice have been reported to develop drusen and phenotypic features similar to AMD, including an ..
  39. Semple B, Bye N, Rancan M, Ziebell J, Morganti Kossmann M. Role of CCL2 (MCP-1) in traumatic brain injury (TBI): evidence from severe TBI patients and CCL2-/- mice. J Cereb Blood Flow Metab. 2010;30:769-82 pubmed publisher
    ..The chemokine CC ligand-2 (CCL2) (formerly monocyte chemoattractant protein-1, MCP-1) is implicated in macrophage recruitment into damaged ..
  40. Sul O, Ke K, Kim W, Kim S, Lee S, Kim H, et al. Absence of MCP-1 leads to elevated bone mass via impaired actin ring formation. J Cell Physiol. 2012;227:1619-27 pubmed publisher
    ..The higher bone mass in the femurs of MCP-1-KO mice could be, at least in part, due to decreased osteoclastogenesis and bone resorption resulting from aberrant M-CSF signaling in OCs. ..
  41. Lu X, Kang Y. Chemokine (C-C motif) ligand 2 engages CCR2+ stromal cells of monocytic origin to promote breast cancer metastasis to lung and bone. J Biol Chem. 2009;284:29087-96 pubmed publisher
    ..Overexpression of the chemokine (C-C motif) ligand 2 (CCL2) is frequently associated with advanced tumor stage and metastatic relapse in breast cancer...
  42. Ding X, Patel M, Shen D, Herzlich A, Cao X, Villasmil R, et al. Enhanced HtrA2/Omi expression in oxidative injury to retinal pigment epithelial cells and murine models of neurodegeneration. Invest Ophthalmol Vis Sci. 2009;50:4957-66 pubmed publisher
    ..serine protease with a proapoptosis function, under H(2)O(2)-induced oxidative stress in human RPE, in the Ccl2(-)(/)(-)Cx3cr1(-)(/)(-) double-knockout (DKO) mouse retina, and the HtrA2/Omi-deficient mice...
  43. Nakano H, Lin K, Yanagita M, Charbonneau C, Cook D, Kakiuchi T, et al. Blood-derived inflammatory dendritic cells in lymph nodes stimulate acute T helper type 1 immune responses. Nat Immunol. 2009;10:394-402 pubmed publisher
    ..This monocyte extravasation required the chemokine receptor CCR2 but not the chemokine CCL2 or receptor CCR7...
  44. Schilling M, Strecker J, Schäbitz W, Ringelstein E, Kiefer R. Effects of monocyte chemoattractant protein 1 on blood-borne cell recruitment after transient focal cerebral ischemia in mice. Neuroscience. 2009;161:806-12 pubmed publisher
    b>Monocyte chemoattractant protein 1 (MCP-1) plays an important role in inflammatory reactions following cerebral ischemia...
  45. Kaneko H, Dridi S, Tarallo V, Gelfand B, Fowler B, Cho W, et al. DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration. Nature. 2011;471:325-30 pubmed publisher
    ..These findings reveal a miRNA-independent cell survival function for DICER1 involving retrotransposon transcript degradation, show that Alu RNA can directly cause human pathology, and identify new targets for a major cause of blindness. ..
  46. Takeda A, Baffi J, Kleinman M, Cho W, Nozaki M, Yamada K, et al. CCR3 is a target for age-related macular degeneration diagnosis and therapy. Nature. 2009;460:225-30 pubmed publisher
    ..CCR3 targeting might reduce vision loss due to AMD through early detection and therapeutic angioinhibition. ..
  47. Kassel K, Guo G, Tawfik O, Luyendyk J. Monocyte chemoattractant protein-1 deficiency does not affect steatosis or inflammation in livers of mice fed a methionine-choline-deficient diet. Lab Invest. 2010;90:1794-804 pubmed publisher
    Monocyte chemoattractant protein-1 (MCP-1, Ccl2) expression is increased in livers of patients with nonalcoholic steatohepatitis and in murine models of steatohepatitis...
  48. Giraud S, Caron C, Pham Dinh D, Kitabgi P, Nicot A. Estradiol inhibits ongoing autoimmune neuroinflammation and NFkappaB-dependent CCL2 expression in reactive astrocytes. Proc Natl Acad Sci U S A. 2010;107:8416-21 pubmed publisher
    ..pregnancy levels of 17beta-estradiol (E2) alleviate ongoing disease and decrease astrocytic production of CCL2, a proinflammatory chemokine that drives the local recruitment of inflammatory myeloid cells...
  49. Tieu B, Lee C, Sun H, Lejeune W, Recinos A, Ju X, et al. An adventitial IL-6/MCP1 amplification loop accelerates macrophage-mediated vascular inflammation leading to aortic dissection in mice. J Clin Invest. 2009;119:3637-51 pubmed publisher
  50. Yang S, IglayReger H, Kadouh H, Bodary P. Inhibition of the chemokine (C-C motif) ligand 2/chemokine (C-C motif) receptor 2 pathway attenuates hyperglycaemia and inflammation in a mouse model of hepatic steatosis and lipoatrophy. Diabetologia. 2009;52:972-81 pubmed publisher
    Using a mouse model of lipoatrophic diabetes, we hypothesised that the chemokine (C-C motif) ligand 2 (CCL2)/chemokine (C-C motif) receptor 2 (CCR2) pathway contributes to hepatic macrophage accumulation and insulin resistance through ..
  51. Yao Y, Tsirka S. The CCL2-CCR2 system affects the progression and clearance of intracerebral hemorrhage. Glia. 2012;60:908-18 pubmed publisher
    Intracerebral hemorrhage (ICH) has been associated with inflammation and apoptosis. The CCL2-CCR2 chemotactic system is one of the major signaling pathways that induce inflammation and apoptosis...
  52. Heinrich J, Ryseck R, Macdonald Bravo H, Bravo R. The product of a novel growth factor-activated gene, fic, is a biologically active "C-C"-type cytokine. Mol Cell Biol. 1993;13:2020-30 pubmed
    ..The fic protein, FIC, shows highest sequence homology (57%) to human and rabbit monocyte chemoattractant protein 1 (MCP-1), an established monocyte activator...
  53. Yamamoto M, Horiba M, Buescher J, Huang D, Gendelman H, Ransohoff R, et al. Overexpression of monocyte chemotactic protein-1/CCL2 in beta-amyloid precursor protein transgenic mice show accelerated diffuse beta-amyloid deposition. Am J Pathol. 2005;166:1475-85 pubmed
    ..bigenic mouse that overexpresses both amyloid precursor protein (APP) and monocyte chemotactic protein-1 (MCP-1; CCL2 in systematic nomenclature)...
  54. Sartipy P, Loskutoff D. Monocyte chemoattractant protein 1 in obesity and insulin resistance. Proc Natl Acad Sci U S A. 2003;100:7265-70 pubmed
    This study identifies monocyte chemoattractant protein 1 (MCP-1) as an insulin-responsive gene...
  55. Henderson R, Hobbs J, Mathies M, Hogg N. Rapid recruitment of inflammatory monocytes is independent of neutrophil migration. Blood. 2003;102:328-35 pubmed
    ..The murine monocyte therefore responds rapidly to chemokines produced in situ by tissue cells at the site of inflammation with no requirement for prior influx of neutrophils. ..