Ccl11

Summary

Gene Symbol: Ccl11
Description: chemokine (C-C motif) ligand 11
Alias: Scya11, eotaxin, eotaxin, C-C motif chemokine 11, eosinophil chemotactic protein, small chemokine (C-C motif) ligand 11, small-inducible cytokine A11
Species: mouse
Products:     Ccl11

Top Publications

  1. Quackenbush E, Aguirre V, Wershil B, Gutierrez Ramos J. Eotaxin influences the development of embryonic hematopoietic progenitors in the mouse. J Leukoc Biol. 1997;62:661-6 pubmed
    b>Eotaxin is a potent chemoattractant for eosinophils during inflammation and allergic reactions in the adult, but its role during development has not been studied...
  2. Leasure C, Chandler J, Gilbert D, Householder D, Stephens R, Copeland N, et al. Sequence, chromosomal location and expression analysis of the murine homologue of human RAD51L2/RAD51C. Gene. 2001;271:59-67 pubmed
    ..The murine Rad51l2 gene maps to chromosome 11 and is located in the syntenic region of human chromosome 17q22-23, where the human RAD51L2 is present. ..
  3. Pope S, Zimmermann N, Stringer K, Karow M, Rothenberg M. The eotaxin chemokines and CCR3 are fundamental regulators of allergen-induced pulmonary eosinophilia. J Immunol. 2005;175:5341-50 pubmed
    The eotaxin chemokines have been implicated in allergen-induced eosinophil responses in the lung. However, the individual and combined contribution of each of the individual eotaxins is not well defined...
  4. Hogan S, Mishra A, Brandt E, Royalty M, Pope S, Zimmermann N, et al. A pathological function for eotaxin and eosinophils in eosinophilic gastrointestinal inflammation. Nat Immunol. 2001;2:353-60 pubmed
    ..disease, we report the pathological consequences of eosinophilic inflammation and the involvement of eotaxin and eosinophils...
  5. Campbell E, Kunkel S, Strieter R, Lukacs N. Differential roles of IL-18 in allergic airway disease: induction of eotaxin by resident cell populations exacerbates eosinophil accumulation. J Immunol. 2000;164:1096-102 pubmed
    ..A possible mechanism was observed in a significant increase in eotaxin, but not other eosinophil chemotactic factors, in bronchoalveolar lavage fluid after IL-18 instillation...
  6. Rothenberg M, MacLean J, Pearlman E, Luster A, Leder P. Targeted disruption of the chemokine eotaxin partially reduces antigen-induced tissue eosinophilia. J Exp Med. 1997;185:785-90 pubmed
    ..b>Eotaxin is a C-C chemokine implicated in the recruitment of eosinophils in a variety of inflammatory disorders and, ..
  7. Rothenberg M, Luster A, Leder P. Murine eotaxin: an eosinophil chemoattractant inducible in endothelial cells and in interleukin 4-induced tumor suppression. Proc Natl Acad Sci U S A. 1995;92:8960-4 pubmed
    Guinea pig eotaxin is a recently described member of the Cys-Cys family of chemokines and is involved in a guinea pig model of asthma...
  8. Kudlacz E, Whitney C, Andresenl C, Conklyn M. Functional effects of eotaxin are selectively upregulated on IL-5 transgenic mouse eosinophils. Inflammation. 2002;26:111-9 pubmed
    ..Functional responsiveness to eotaxin was increased in IL5TG eosinophils as demonstrated by a 10x increase in its potency in producing actin ..
  9. Zhu Z, Homer R, Wang Z, Chen Q, Geba G, Wang J, et al. Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production. J Clin Invest. 1999;103:779-88 pubmed
    ..b>Eotaxin protein and mRNA were also present in large quantities in the lungs of the transgene-positive, but not the ..

More Information

Publications81

  1. Ganzalo J, Jia G, Aguirre V, Friend D, Coyle A, Jenkins N, et al. Mouse Eotaxin expression parallels eosinophil accumulation during lung allergic inflammation but it is not restricted to a Th2-type response. Immunity. 1996;4:1-14 pubmed
    ..and cloning of a cDNA that encodes a mouse C-C chemokine with 68% amino acid identity to guinea pig Eotaxin. The recombinant protein encoded by this gene displays potent and specific chemotactic activity for eosinophils, ..
  2. Rothenberg M, Luster A, Lilly C, Drazen J, Leder P. Constitutive and allergen-induced expression of eotaxin mRNA in the guinea pig lung. J Exp Med. 1995;181:1211-6 pubmed
    b>Eotaxin is a member of the C-C family of chemokines and is related during antigen challenge in a guinea pig model of allergic airway inflammation (asthma)...
  3. Jose P, Griffiths Johnson D, Collins P, Walsh D, Moqbel R, Totty N, et al. Eotaxin: a potent eosinophil chemoattractant cytokine detected in a guinea pig model of allergic airways inflammation. J Exp Med. 1994;179:881-7 pubmed
    ..The protein, "eotaxin," exhibits homology of 53% with human MCP-1, 44% with guinea pig MCP-1, 31% with human MIP-1 alpha, and 26% with ..
  4. Yang M, Hogan S, Henry P, Matthaei K, McKenzie A, Young I, et al. Interleukin-13 mediates airways hyperreactivity through the IL-4 receptor-alpha chain and STAT-6 independently of IL-5 and eotaxin. Am J Respir Cell Mol Biol. 2001;25:522-30 pubmed
    ..the role of eosinophils in the induction of IP AHR and mucus hypersecretion, we administered IL-13 to IL-5-, eotaxin-, and IL-5/eotaxin- deficient mice...
  5. Munitz A, Brandt E, Mingler M, Finkelman F, Rothenberg M. Distinct roles for IL-13 and IL-4 via IL-13 receptor alpha1 and the type II IL-4 receptor in asthma pathogenesis. Proc Natl Acad Sci U S A. 2008;105:7240-5 pubmed publisher
    ..Furthermore, we demonstrate that increased airway resistance, mucus, TGF-beta, and eotaxin(s) production, but not cellular infiltration, are critically dependent on IL-13Ralpha1...
  6. Williams A, José R, Brown J, Chambers R. Enhanced inflammation in aged mice following infection with Streptococcus pneumoniae is associated with decreased IL-10 and augmented chemokine production. Am J Physiol Lung Cell Mol Physiol. 2015;308:L539-49 pubmed publisher
    ..infection, compared with young mice, but increased levels of the chemokines CXCL9, CXCL12, CCL3, CCL4, CCL5, CCL11, and CCL17. Moreover, levels of IL-10 were significantly lower in aged animals...
  7. Fritz D, Kerr C, Botelho F, Stampfli M, Richards C. Oncostatin M (OSM) primes IL-13- and IL-4-induced eotaxin responses in fibroblasts: regulation of the type-II IL-4 receptor chains IL-4Ralpha and IL-13Ralpha1. Exp Cell Res. 2009;315:3486-99 pubmed publisher
    ..that OSM induces eosinophil accumulation in mouse lungs in vivo and stimulates the eosinophil-selective chemokine eotaxin-1 synergistically with IL-4 in vitro...
  8. Beal D, Stepien D, Natarajan S, Kim J, Remick D. Reduction of eotaxin production and eosinophil recruitment by pulmonary autologous macrophage transfer in a cockroach allergen-induced asthma model. Am J Physiol Lung Cell Mol Physiol. 2013;305:L866-77 pubmed publisher
    ..lower levels of eosinophil peroxidase in the lung and significantly lower concentrations of eotaxins in BAL (eotaxin 1: 3 pg/ml vs. undetectable; eotaxin 2: 2,383 vs. 131 pg/ml) and lung homogenate (eotaxin 1: 1,043 vs...
  9. Mishra A, Hogan S, Brandt E, Rothenberg M. IL-5 promotes eosinophil trafficking to the esophagus. J Immunol. 2002;168:2464-9 pubmed
    ..Importantly, IL-5-deficient mice were resistant to eosinophilic esophagitis. Finally, we examined the role of eotaxin when IL-5 was overproduced in vivo...
  10. Sharkhuu T, Matthaei K, Forbes E, Mahalingam S, Hogan S, Hansbro P, et al. Mechanism of interleukin-25 (IL-17E)-induced pulmonary inflammation and airways hyper-reactivity. Clin Exp Allergy. 2006;36:1575-83 pubmed
    ..Levels of arginase-I (arg-I) and eotaxin were also elevated by IL-25 treatment...
  11. Swartz D, Park E, Visek W, Kaput J. The e subunit gene of murine F1F0-ATP synthase. Genomic sequence, chromosomal mapping, and diet regulation. J Biol Chem. 1996;271:20942-8 pubmed
    ..The implications of the high degree of sequence similarity to the e subunit for rat and bovine F1F0-ATP synthase and its regulation by diet are discussed. ..
  12. Diny N, Hou X, Barin J, Chen G, Talor M, Schaub J, et al. Macrophages and cardiac fibroblasts are the main producers of eotaxins and regulate eosinophil trafficking to the heart. Eur J Immunol. 2016;46:2749-2760 pubmed publisher
    ..Two conditions are necessary for efficient eosinophil trafficking to the heart: high eotaxin (CCL11, CCL24) expression in the heart and expression of the eotaxin receptor CCR3 by eosinophils...
  13. Albert E, Duplisea J, Dawicki W, Haidl I, Marshall J. Tissue eosinophilia in a mouse model of colitis is highly dependent on TLR2 and independent of mast cells. Am J Pathol. 2011;178:150-60 pubmed publisher
    ..Decreased eosinophilia in TLR2(-/-) mice was associated with lower levels of cecal CCL11 (P < 0.01)...
  14. Mishra A, Rothenberg M. Intratracheal IL-13 induces eosinophilic esophagitis by an IL-5, eotaxin-1, and STAT6-dependent mechanism. Gastroenterology. 2003;125:1419-27 pubmed
    ..IL-13 was delivered intratracheally to wild-type, signal transducer and activator of transcription (STAT) 6, eotaxin-1, or IL-5-deficient mice...
  15. Ben Yehuda C, Bader R, Puxeddu I, Levi Schaffer F, Breuer R, Berkman N. Airway eosinophil accumulation and eotaxin-2/CCL24 expression following allergen challenge in BALB/c mice. Exp Lung Res. 2008;34:467-79 pubmed publisher
    b>Eotaxin-1/CCL11 is important for early eosinophil recruitment to the airways of asthmatics...
  16. Takeda A, Baffi J, Kleinman M, Cho W, Nozaki M, Yamada K, et al. CCR3 is a target for age-related macular degeneration diagnosis and therapy. Nature. 2009;460:225-30 pubmed publisher
    ..in choroidal neovascular endothelial cells in humans with AMD, and that despite the expression of its ligands eotaxin-1, -2 and -3, neither eosinophils nor mast cells are present in human CNV...
  17. Queto T, Gaspar Elsas M, Masid de Brito D, Vasconcelos Z, Ferraris F, Penido C, et al. Cysteinyl-leukotriene type 1 receptors transduce a critical signal for the up-regulation of eosinophilopoiesis by interleukin-13 and eotaxin in murine bone marrow. J Leukoc Biol. 2010;87:885-93 pubmed publisher
    IL-13 and eotaxin play important, inter-related roles in asthma models...
  18. Wang L, Shah P, Wang W, Song L, Yang M, Sharifi B. Tenascin-C deficiency in apo E-/- mouse increases eotaxin levels: implications for atherosclerosis. Atherosclerosis. 2013;227:267-74 pubmed publisher
    ..Cytokine array analysis and subsequent ELISA showed that circulating eotaxin levels were selectively and markedly increased in response to TNC gene deletion in apo E-/- mice...
  19. Fulkerson P, Fischetti C, Rothenberg M. Eosinophils and CCR3 regulate interleukin-13 transgene-induced pulmonary remodeling. Am J Pathol. 2006;169:2117-26 pubmed
    ..this, we mated IL-13-inducible lung transgenic mice with mice deficient in eosinophil chemoattractant molecules (eotaxin-1, eotaxin-2, and their receptor CCR3) and with mice genetically deficient in eosinophils (Deltadbl-GATA)...
  20. Sokulsky L, Collison A, Nightingale S, Fevre A, Percival E, Starkey M, et al. TRAIL deficiency and PP2A activation with salmeterol ameliorates egg allergen-driven eosinophilic esophagitis. Am J Physiol Gastrointest Liver Physiol. 2016;311:G998-G1008 pubmed publisher
    ..protected from esophageal fibrosis, eosinophilic inflammation, and the upregulation of TSLP, IL-5, IL-13, and CCL11 when compared with wild-type mice...
  21. Baek K, Cho J, Rosenthal P, Alexander L, Nizet V, Broide D. Hypoxia potentiates allergen induction of HIF-1?, chemokines, airway inflammation, TGF-?1, and airway remodeling in a mouse model. Clin Immunol. 2013;147:27-37 pubmed publisher
    ..The combination of hypoxia and OVA allergen increased eotaxin-1, peribronchial eosinophils, lung TGB-?1 expression, and indices of airway remodeling (fibrosis and smooth ..
  22. Wang F, Baba N, Shen Y, Yamashita T, Tsuru E, Tsuda M, et al. CCL11 promotes migration and proliferation of mouse neural progenitor cells. Stem Cell Res Ther. 2017;8:26 pubmed publisher
    ..In vitro studies showed that incubation of NPCs with recombinant mouse CCL11 promoted migration and proliferation. These effects were partly inhibited by a CCR3 antagonist, SB297006...
  23. Rajavelu P, Rayapudi M, Moffitt M, Mishra A, Mishra A. Significance of para-esophageal lymph nodes in food or aeroallergen-induced iNKT cell-mediated experimental eosinophilic esophagitis. Am J Physiol Gastrointest Liver Physiol. 2012;302:G645-54 pubmed publisher
    ..Furthermore, experimentation with gene-targeted mice revealed that peanut allergen-induced EoE was dependent on eotaxin and invariant natural killer T (iNKT) cells, as CD1d and eotaxin-1/2 gene-deficient mice were protected from ..
  24. Simson L, Ellyard J, Dent L, Matthaei K, Rothenberg M, Foster P, et al. Regulation of carcinogenesis by IL-5 and CCL11: a potential role for eosinophils in tumor immune surveillance. J Immunol. 2007;178:4222-9 pubmed
    ..fibrosarcomas in IL-5 transgenic mice that have greatly enhanced levels of circulating eosinophils, CCL11 (eotaxin-1)-deficient mice that lack a key chemokine that recruits eosinophils into tissues, and the eosinophil-deficient ..
  25. Chandra G, Rangasamy S, Roy A, Kordower J, Pahan K. Neutralization of RANTES and Eotaxin Prevents the Loss of Dopaminergic Neurons in a Mouse Model of Parkinson Disease. J Biol Chem. 2016;291:15267-81 pubmed publisher
    ..we found a rapid increase in RANTES (regulated on activation normal T cell expressed and secreted) and eotaxin, chemokines that are involved in T cell trafficking, in vivo in the substantia nigra pars compacta and the serum ..
  26. Neilsen C, Bryce P. Interleukin-13 directly promotes oesophagus production of CCL11 and CCL24 and the migration of eosinophils. Clin Exp Allergy. 2010;40:427-34 pubmed publisher
    ..These were treated in vitro with IL-4 or IL-13 and the expression and production of CCL11 and CCL24 were determined...
  27. Eum S, Maghni K, Tolloczko B, Eidelman D, Martin J. IL-13 may mediate allergen-induced hyperresponsiveness independently of IL-5 or eotaxin by effects on airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 2005;288:L576-84 pubmed
    ..The aim of this study was to evaluate whether eotaxin and IL-5 were implicated in the effects of IL-13 on allergen-induced AHR or whether IL-13 may exert its effects ..
  28. Cohen Tannoudji M, Vandormael Pournin S, Le Bras S, Coumailleau F, Babinet C, Baldacci P. A 2-Mb YAC/BAC-based physical map of the ovum mutant (Om) locus region on mouse chromosome 11. Genomics. 2000;68:273-82 pubmed
    ..Two other genes (Rad51l3 and Schlafen 2) and one EST (D11Wsu78e) were also mapped in the Om region. This integrated map provides support for the identification of additional candidate genes for the DDK syndrome. ..
  29. Cheng S, Lukacs N, Kunkel S. Eotaxin/CCL11 is a negative regulator of neutrophil recruitment in a murine model of endotoxemia. Exp Mol Pathol. 2002;73:1-8 pubmed
    b>Eotaxin/CCL11 is a chemokine that has been primarily characterized with respect to its eosinophil chemoattractant activity. However, the broad tissue expression of eotaxin/CCL11 suggests that it may have other unknown activities...
  30. Vieira de Abreu A, Calheiros A, Mesquita Santos F, Magalhães E, Mourão Sá D, Castro Faria Neto H, et al. Cross-talk between macrophage migration inhibitory factor and eotaxin in allergic eosinophil activation forms leukotriene C?-synthesizing lipid bodies. Am J Respir Cell Mol Biol. 2011;44:509-16 pubmed publisher
    ..eosinophil lipid body biogenesis, both in vivo and in vitro, was dependent on the cooperation of MIF and eotaxin acting in a positive-feedback loop, because anti-eotaxin and anti-CCR3 antibodies inhibit MIF-elicited lipid body ..
  31. Dixon H, Blanchard C, deSchoolmeester M, Yuill N, Christie J, Rothenberg M, et al. The role of Th2 cytokines, chemokines and parasite products in eosinophil recruitment to the gastrointestinal mucosa during helminth infection. Eur J Immunol. 2006;36:1753-63 pubmed
    ..The chemokine CCL11 is agonist for the chemokine receptor CCR3 and acts in synergy with IL-5 to recruit eosinophils to inflammatory ..
  32. Waddell A, Ahrens R, Steinbrecher K, Donovan B, Rothenberg M, Munitz A, et al. Colonic eosinophilic inflammation in experimental colitis is mediated by Ly6C(high) CCR2(+) inflammatory monocyte/macrophage-derived CCL11. J Immunol. 2011;186:5993-6003 pubmed publisher
    ..inflammatory bowel disease have implicated the 17q12 loci, which contains the eosinophil-specific chemokine gene CCL11, with early-onset inflammatory bowel disease susceptibility...
  33. Wan D, Zhang X, Liu X, Li G. Protection of montelukast on OVA-induced eosinophilic gastroenteritis via modulating IL-5, eotaxin-1 and MBP expression. Immunopharmacol Immunotoxicol. 2013;35:625-6 pubmed publisher
    ..The results indicated that montelukast could prevent levels of eotaxin-1 and interleukin-5 in intestinal mucosa homogenate when compared with model group...
  34. Pope S, Brandt E, Mishra A, Hogan S, Zimmermann N, Matthaei K, et al. IL-13 induces eosinophil recruitment into the lung by an IL-5- and eotaxin-dependent mechanism. J Allergy Clin Immunol. 2001;108:594-601 pubmed
    ..We hypothesized that IL-13-induced inflammatory changes in the lung were dependent in part on IL-5 and eotaxin, two eosinophil-selective cytokines...
  35. Kodali R, Kim W, Galaria I, Miller C, Schecter A, Lira S, et al. CCL11 (Eotaxin) induces CCR3-dependent smooth muscle cell migration. Arterioscler Thromb Vasc Biol. 2004;24:1211-6 pubmed
    CCL11 (Eotaxin) is a potent eosinophil chemoattractant that is abundant in atheromatous plaques. The major receptor for CCL11 is CCR3, which is found on leukocytes and on some nonleukocytic cells...
  36. Medeiros A, Malheiro A, Jose P, Conroy D, Williams T, Faccioli L. Differential release of MIP-1alpha and eotaxin during infection of mice by Histoplasma capsulatum or inoculation of beta-glucan. Inflamm Res. 2004;53:351-4 pubmed
    In the present study, we evaluated the levels of MIP-1alpha and eotaxin and in vivo migration in the peritoneal cavity model, in mice inoculated with live yeast forms of Histoplasma capsulatum or the beta-glucan cell wall component of ..
  37. Mishra A, Weaver T, Beck D, Rothenberg M. Interleukin-5-mediated allergic airway inflammation inhibits the human surfactant protein C promoter in transgenic mice. J Biol Chem. 2001;276:8453-9 pubmed
    ..The hSP-C 3.7-kilobase pair promoter was used to direct the expression of eotaxin, an eosinophil-selective chemokine, into the lungs of several transgenic lines...
  38. Stevenson N, Addley M, Ryan E, Boyd C, Carroll H, Paunovic V, et al. CCL11 blocks IL-4 and GM-CSF signaling in hematopoietic cells and hinders dendritic cell differentiation via suppressor of cytokine signaling expression. J Leukoc Biol. 2009;85:289-97 pubmed publisher
    The chemokine eotaxin/CCL11 is an important mediator of leukocyte migration, but its effect on inflammatory cytokine signaling has not been explored...
  39. Gouon Evans V, Rothenberg M, Pollard J. Postnatal mammary gland development requires macrophages and eosinophils. Development. 2000;127:2269-82 pubmed
    ..Similarly, by using mice homozygous for a null mutation in the gene for eotaxin, a major chemokine for local recruitment of eosinophils in tissue, we identify eotaxin as the necessary and ..
  40. Johnson T, Rothenberg M, Graham B. Pulmonary eosinophilia requires interleukin-5, eotaxin-1, and CD4+ T cells in mice immunized with respiratory syncytial virus G glycoprotein. J Leukoc Biol. 2008;84:748-59 pubmed publisher
    ..We now address the contributions of IL-5, eotaxin-1, and CD4+ and CD8+ T cells to the induction of disease-enhancing immune responses...
  41. Heller N, Gwinn W, Donnelly R, Constant S, Keegan A. IL-4 engagement of the type I IL-4 receptor complex enhances mouse eosinophil migration to eotaxin-1 in vitro. PLoS ONE. 2012;7:e39673 pubmed publisher
    ..do not chemotax to IL-4 or IL-13 although (iii) pre-treatment with IL-4 but not IL-13 enhanced migration to eotaxin-1...
  42. Parajuli B, Horiuchi H, Mizuno T, Takeuchi H, Suzumura A. CCL11 enhances excitotoxic neuronal death by producing reactive oxygen species in microglia. Glia. 2015;63:2274-84 pubmed publisher
    The chemokine CCL11 (also known as eotaxin-1) is a potent eosinophil chemoattractant that mediates allergic diseases such as asthma, atopic dermatitis, and inflammatory bowel diseases...
  43. Adar T, Shteingart S, Ben Ya acov A, Shitrit A, Livovsky D, Shmorak S, et al. The Importance of Intestinal Eotaxin-1 in Inflammatory Bowel Disease: New Insights and Possible Therapeutic Implications. Dig Dis Sci. 2016;61:1915-24 pubmed publisher
    Involvement of eotaxin-1 in inflammatory bowel disease has been previously suggested and increased levels of eotaxin-1 have been described in both ulcerative colitis and in Crohn's disease...
  44. Semik Orzech A, Barczyk A, Wiaderkiewicz R, Pierzchała W. Eotaxin, but not IL-8, is increased in upper and lower airways of allergic rhinitis subjects after nasal allergen challenge. Allergy Asthma Proc. 2011;32:230-8 pubmed publisher
    The aim of this study was to assess the impact of a single nasal allergen challenge (NAC) on levels of eotaxin and IL-8 and the inflammatory cells in upper and lower airways of allergic rhinitis (AR) patients...
  45. Wang A, Fernando M, Leung G, Phan V, Smyth D, McKay D. Exacerbation of oxazolone colitis by infection with the helminth Hymenolepis diminuta: involvement of IL-5 and eosinophils. Am J Pathol. 2010;177:2850-9 pubmed publisher
    ..IL-5) gene or a control adenovirus (Ad.delete) ± oxazolone. The effect of H. diminuta+oxazolone in CCL11/CCL22 (eotaxin-1 and 2) knockout (KO) mice was determined. Helminth infection and Ad...
  46. Gentil K, Lentz C, Rai R, Muhsin M, Kamath A, Mutluer O, et al. Eotaxin-1 is involved in parasite clearance during chronic filarial infection. Parasite Immunol. 2014;36:60-77 pubmed publisher
    ..In a mouse model of filariasis, we investigated the role of the eosinophil-attracting chemokine Eotaxin-1 on disease outcome...
  47. Cottle D, Ursino G, Ip S, Jones L, DiTommaso T, Hacking D, et al. Fetal inhibition of inflammation improves disease phenotypes in harlequin ichthyosis. Hum Mol Genet. 2015;24:436-49 pubmed publisher
    ..These studies highlight inflammation as an unexpected contributor to HI disease development in utero, and suggest that inhibiting inflammation may reduce disease severity. ..
  48. Garcia Zepeda E, Rothenberg M, Weremowicz S, Sarafi M, Morton C, Luster A. Genomic organization, complete sequence, and chromosomal location of the gene for human eotaxin (SCYA11), an eosinophil-specific CC chemokine. Genomics. 1997;41:471-6 pubmed
    b>Eotaxin is a CC chemokine that is a specific chemoattractant for eosinophils and is implicated in the pathogenesis of eosinophilic inflammatory diseases, such as asthma...
  49. Knott M, Matthaei K, Foster P, Dent L. The roles of eotaxin and the STAT6 signalling pathway in eosinophil recruitment and host resistance to the nematodes Nippostrongylus brasiliensis and Heligmosomoides bakeri. Mol Immunol. 2009;46:2714-22 pubmed publisher
    ..brasiliensis. This study was designed to assess the importance of the eosinophil chemokine eotaxin and the STAT6/interleukin (IL)-4/IL-13 signalling pathway in early resistance to N. brasiliensis...
  50. Chang E, Chung L, Yen C. Kinetics of change in the eotaxin concentration in serum and cerebrospinal fluid of mice infected with Angiostrongylus cantonensis. Parasitol Res. 2004;92:137-41 pubmed
    The kinetics of changes in the eotaxin concentration in the serum and cerebrospinal fluid (CSF) of BALB/c mice after infection with Angiostrongylus cantonensis and the correlation between the concentration of eotaxin and worm recovery ..
  51. Boehme S, Lio F, Sikora L, Pandit T, Lavrador K, Rao S, et al. Cutting edge: serotonin is a chemotactic factor for eosinophils and functions additively with eotaxin. J Immunol. 2004;173:3599-603 pubmed
    ..we demonstrate that 5-HT functions independently as an eosinophil chemoattractant that acts additively with eotaxin. 5-HT2A receptor antagonists (including MDL-100907 and cyproheptadine (CYP)) were found to inhibit 5-HT-induced, ..
  52. Unruh D, Srinivasan R, Benson T, Haigh S, Coyle D, Batra N, et al. Red Blood Cell Dysfunction Induced by High-Fat Diet: Potential Implications for Obesity-Related Atherosclerosis. Circulation. 2015;132:1898-908 pubmed publisher
    ..These findings may have implications for the pathogenesis of atherosclerosis in obesity, a worldwide epidemic. ..
  53. Ji Y, Kim H, Bae K, Lee S, Kim M, Ryoo Z. Hepatic serum amyloid A1 aggravates T cell-mediated hepatitis by inducing chemokines via Toll-like receptor 2 in mice. J Biol Chem. 2015;290:12804-11 pubmed publisher
    ..monocyte chemotactic protein 1 (MCP1), MIP1α, MIP1β, interferon γ-induced protein 10 (IP-10), and eotaxin were induced in Saa1 TG mice...
  54. Duchesnes C, Murphy P, Williams T, Pease J. Alanine scanning mutagenesis of the chemokine receptor CCR3 reveals distinct extracellular residues involved in recognition of the eotaxin family of chemokines. Mol Immunol. 2006;43:1221-31 pubmed
    Despite considerable differences in primary structure, the chemokines eotaxin-1/CCL11, eotaxin-2/CCL24 and eotaxin-3/CCL26 signal via a single receptor, CCR3, but exhibit different potencies and efficacies...
  55. Matos N, Silva J, Damasceno K, Cassali G, Lemos V, Duarte I, et al. Proteinase-activated receptor 2 blockade impairs CCL11- or allergen-induced eosinophil recruitment in experimental pleurisy. Eur J Pharmacol. 2014;740:627-33 pubmed publisher
    ..SLIGRL-NH2) induced eosinophil recruitment whereas PAR-2 blockade inhibited ovalbumin (OVA)- or CCL11-induced eosinophil recruitment...
  56. Ahrens R, Waddell A, Seidu L, Blanchard C, Carey R, Forbes E, et al. Intestinal macrophage/epithelial cell-derived CCL11/eotaxin-1 mediates eosinophil recruitment and function in pediatric ulcerative colitis. J Immunol. 2008;181:7390-9 pubmed
    Clinical studies have demonstrated a link between the eosinophil-selective chemokines, eotaxins (eotaxin-1/CCL11 and eotaxin-2/CCL24), eosinophils, and the inflammatory bowel diseases, Crohn's disease and ulcerative colitis (UC)...
  57. Krulova M, Havelková H, Kosarová M, Holan V, Hart A, Demant P, et al. IL-2-induced proliferative response is controlled by loci Cinda1 and Cinda2 on mouse chromosomes 11 and 12: a distinct control of the response induced by different IL-2 concentrations. Genomics. 1997;42:11-5 pubmed
    ..Understanding the action of genetic factors, such as Cinda1 and Cinda2, that control T cell function is expected to contribute to the efficient analysis of the genetic control of susceptibility to infections and autoimmune diseases. ..
  58. Forbes E, Murase T, Yang M, Matthaei K, Lee J, Lee N, et al. Immunopathogenesis of experimental ulcerative colitis is mediated by eosinophil peroxidase. J Immunol. 2004;172:5664-75 pubmed
    ..In this study, we have used a mouse model of UC to establish a central role for eotaxin and, in turn, eosinophils in the development of the immunopathogenesis of this disease...
  59. Simons J, Rothenberg M, Lawrence R. Eotaxin-1-regulated eosinophils have a critical role in innate immunity against experimental Brugia malayi infection. Eur J Immunol. 2005;35:189-97 pubmed
    ..contained in distinct anatomical compartments, in blood or tissue sites, we have demonstrated a critical role for eotaxin-1 in parasite clearance. In the first model, implantation of adult B...
  60. Yang Y, Loy J, Ryseck R, Carrasco D, Bravo R. Antigen-induced eosinophilic lung inflammation develops in mice deficient in chemokine eotaxin. Blood. 1998;92:3912-23 pubmed
    ..The CC chemokine eotaxin is a potent chemoattractant, highly specific for eosinophils...
  61. Sarafi M, Garcia Zepeda E, MacLean J, Charo I, Luster A. Murine monocyte chemoattractant protein (MCP)-5: a novel CC chemokine that is a structural and functional homologue of human MCP-1. J Exp Med. 1997;185:99-109 pubmed
    ..These data indicate that MCP-5 is a novel and potent monocyte active chemokine that is involved in allergic inflammation and the host response to pathogens. ..
  62. Kurokawa M, Matsukura S, Kawaguchi M, Ieki K, Suzuki S, Odaka M, et al. Expression and effects of IL-33 and ST2 in allergic bronchial asthma: IL-33 induces eotaxin production in lung fibroblasts. Int Arch Allergy Immunol. 2011;155 Suppl 1:12-20 pubmed publisher
    ..IL-33 induced eotaxin/CCL11 production in lung fibroblasts. IL-33 and IL-13 synergistically induced eotaxin expression...
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