Cckar

Summary

Gene Symbol: Cckar
Description: cholecystokinin A receptor
Alias: AW106902, CCK-A receptor, CCK-AR, CCK1-R, cholecystokinin receptor type A, cholecystokinin-1 receptor
Species: mouse

Top Publications

  1. pmc CCK(1) receptor is essential for normal meal patterning in mice fed high fat diet
    Michael J Donovan
    Department of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, University of California Davis, California 95616, United States
    Physiol Behav 92:969-74. 2007
  2. ncbi Murine prenatal expression of cholecystokinin in neural crest, enteric neurons, and enteroendocrine cells
    J M Lay
    Graduate Program in Cellular and Molecular Biology, The University of Michigan, Ann Arbor 48109 0622, USA
    Dev Dyn 216:190-200. 1999
  3. ncbi Energy metabolism and turnover are increased in mice lacking the cholecystokinin-B receptor
    Kyoko Miyasaka
    Department of Clinical Physiology, Tokyo Metropolitan Institute of Gerontology, Tokyo 173 0015, Japan
    J Nutr 132:739-41. 2002
  4. pmc Targeted disruption of the murine cholecystokinin-1 receptor promotes intestinal cholesterol absorption and susceptibility to cholesterol cholelithiasis
    David Q H Wang
    Department of Medicine, Liver Center and Gastroenterology Division, Beth Israel Deaconess Medical Center, Boston, MA, USA
    J Clin Invest 114:521-8. 2004
  5. ncbi Molecular structure of the mouse CCK-A receptor gene
    K A Lacourse
    Department of Physiology, The University of Michigan, Ann Arbor 48109 0622, USA
    Biochem Biophys Res Commun 236:630-5. 1997
  6. pmc Functional compensation between cholecystokinin-1 and -2 receptors in murine paraventricular nucleus neurons
    Shahid Mohammad
    Graduate School of Innovative Life Science, University of Toyama, 3190 Gofuku, Toyama City, Toyama 930 8555, Japan
    J Biol Chem 287:39391-401. 2012
  7. ncbi Cholecystokinin modulates migration of gonadotropin-releasing hormone-1 neurons
    Paolo Giacobini
    Cellular and Developmental Neurobiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 4156, USA
    J Neurosci 24:4737-48. 2004
  8. ncbi Plasminogen activator inhibitor-1 production is pathogenetic in experimental murine diabetic renal disease
    M Lassila
    The Baker Heart Research Institute, Vascular Division, Danielle Alberti Memorial Centre for Diabetes Complications, Melbourne, Victoria, Australia
    Diabetologia 50:1315-26. 2007
  9. ncbi Role of CCK-A receptor for pancreatic function in mice: a study in CCK-A receptor knockout mice
    Soichi Takiguchi
    Division of Chemotherapy, National Kyushu Cancer Center, Minamiku Fukuoka, Japan
    Pancreas 24:276-83. 2002
  10. ncbi Structure and developmental expression of the mouse CCK-B receptor gene
    J M Lay
    Graduate Program in Cellular and Molecular Biology, University of Michigan, Ann Arbor 48109 0622, USA
    Biochem Biophys Res Commun 272:837-42. 2000

Scientific Experts

  • S Bi
  • Grzegorz T Gurda
  • THOMAS FERRARO
  • R T Williams
  • Setsuko Kanai
  • Davor Stanic
  • K Miyasaka
  • A S Kopin
  • Soichi Takiguchi
  • Akihiro Funakoshi
  • Tomoya Ozaki
  • Shahid Mohammad
  • K L Whited
  • Masayuki Ikeda
  • Paolo Giacobini
  • Helen E Raybould
  • Heng Li
  • Eri Morioka
  • J M Lay
  • Léa Ritie
  • Xiaohong Xu
  • Satoshi Miyamoto
  • Guangjing Zhu
  • Minoru Ohta
  • Jennifer Lee
  • Gabriel Paulino
  • Steffen Wolfgang Schubert
  • Takao Shimazoe
  • L C Samuelson
  • Shuzhen Hao
  • M Lassila
  • Michael J Donovan
  • Hyun Joon Kim
  • H E Raybould
  • Chihiro Sakurai
  • Géraldine Ibarz
  • Susan Wray
  • Natsuko Tsujino
  • Akira Kono
  • Shigeki Nomoto
  • David Q H Wang
  • Yuki Yoshida
  • Martin C Carey
  • Malcolm A Lyons
  • Norikazu Sato
  • Yutaka Takata
  • Tetsuo Noda
  • Shinji Suzuki
  • Yukiko Matsushima
  • Masumi Inagaki
  • Yoshiki Matsuda
  • Makiko Kaga
  • Hidenobu Ohta
  • Misaki Akiyama
  • Mika Seki
  • P Carmeliet
  • Hitomi Izumi
  • Yu ichi Goto
  • Takako Toda
  • Annick Klein
  • Tetsuharu Takatsuka
  • C L Pin
  • Dominique Bagnard
  • Haruhito Adam Uchida
  • Kenichi Shikata
  • Shinichi Okada
  • Tetsuro Izumi
  • Bernard Jost
  • Jennifer K Coats
  • Hisakazu Nishimori
  • Nirao M Shah
  • Michele Kedinger
  • Caroline Spenlé
  • Jianqun Yan
  • Hitomi Usui Kataoka
  • Cindy F Yang
  • Joël Lacroute
  • Olivier Lefebvre
  • Christine Bole-Feysot
  • Maricruz Alvarado
  • Shingo Nishishita
  • Gertraud Orend
  • Katsuya Unno
  • Kouhei Takeuchi
  • Motofumi Sasaki
  • Ryo Kodera
  • Daisuke Ogawa
  • Hirofumi Makino
  • Daisho Hirota
  • Nobuo Kajitani

Detail Information

Publications51

  1. pmc CCK(1) receptor is essential for normal meal patterning in mice fed high fat diet
    Michael J Donovan
    Department of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, University of California Davis, California 95616, United States
    Physiol Behav 92:969-74. 2007
    ..These results suggest that the CCK(1)R is involved in regulating caloric intake on a meal to meal basis, but that other factors are responsible for regulation of daily food intake...
  2. ncbi Murine prenatal expression of cholecystokinin in neural crest, enteric neurons, and enteroendocrine cells
    J M Lay
    Graduate Program in Cellular and Molecular Biology, The University of Michigan, Ann Arbor 48109 0622, USA
    Dev Dyn 216:190-200. 1999
    ..5, suggesting that CCK signaling is established early in mouse development. Dev Dyn 1999;216:190-200...
  3. ncbi Energy metabolism and turnover are increased in mice lacking the cholecystokinin-B receptor
    Kyoko Miyasaka
    Department of Clinical Physiology, Tokyo Metropolitan Institute of Gerontology, Tokyo 173 0015, Japan
    J Nutr 132:739-41. 2002
    ..Energy metabolism and energy turnover were increased in mice with a disruption of the CCK-BR gene, although the underlying mechanism is unknown...
  4. pmc Targeted disruption of the murine cholecystokinin-1 receptor promotes intestinal cholesterol absorption and susceptibility to cholesterol cholelithiasis
    David Q H Wang
    Department of Medicine, Liver Center and Gastroenterology Division, Beth Israel Deaconess Medical Center, Boston, MA, USA
    J Clin Invest 114:521-8. 2004
    ....
  5. ncbi Molecular structure of the mouse CCK-A receptor gene
    K A Lacourse
    Department of Physiology, The University of Michigan, Ann Arbor 48109 0622, USA
    Biochem Biophys Res Commun 236:630-5. 1997
    We have cloned the mouse CCK-A receptor gene (Cckar), determined its nucleotide sequence, and analyzed its expression. The receptor protein is encoded in five exons distributed over 9 kb of genomic DNA...
  6. pmc Functional compensation between cholecystokinin-1 and -2 receptors in murine paraventricular nucleus neurons
    Shahid Mohammad
    Graduate School of Innovative Life Science, University of Toyama, 3190 Gofuku, Toyama City, Toyama 930 8555, Japan
    J Biol Chem 287:39391-401. 2012
    ..Compensatory CCK signaling via CCK-2 receptors in CCK1R(-/-) mice shed light on currently controversial satiety-controlling mechanisms...
  7. ncbi Cholecystokinin modulates migration of gonadotropin-releasing hormone-1 neurons
    Paolo Giacobini
    Cellular and Developmental Neurobiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 4156, USA
    J Neurosci 24:4737-48. 2004
    ....
  8. ncbi Plasminogen activator inhibitor-1 production is pathogenetic in experimental murine diabetic renal disease
    M Lassila
    The Baker Heart Research Institute, Vascular Division, Danielle Alberti Memorial Centre for Diabetes Complications, Melbourne, Victoria, Australia
    Diabetologia 50:1315-26. 2007
    ..It is upregulated in experimental and human diabetic nephropathy. These studies assessed the effect of PAI-1 deficiency and overproduction on renal disease in experimental diabetes...
  9. ncbi Role of CCK-A receptor for pancreatic function in mice: a study in CCK-A receptor knockout mice
    Soichi Takiguchi
    Division of Chemotherapy, National Kyushu Cancer Center, Minamiku Fukuoka, Japan
    Pancreas 24:276-83. 2002
    ..The CCK receptors can be pharmacologically subdivided into two subtypes: CCK-A and CCK-B. CCK-A receptor is enriched in the pancreas of mice...
  10. ncbi Structure and developmental expression of the mouse CCK-B receptor gene
    J M Lay
    Graduate Program in Cellular and Molecular Biology, University of Michigan, Ann Arbor 48109 0622, USA
    Biochem Biophys Res Commun 272:837-42. 2000
    ..The expression pattern was similar to the adult pattern, suggesting that receptor transcription is an early event in gastrointestinal development...
  11. ncbi Lack of ghrelin secretion in response to fasting in cholecystokinin-A (-1), -B (-2) receptor-deficient mice
    Chihiro Sakurai
    Department of Clinical Physiology, Tokyo Metropolitan Institute of Gerontology, Tokyo, 173 0015 Japan
    J Physiol Sci 56:441-7. 2006
    ..In conclusion, CCK-AR(-/-)BR(-/-) mice showed lower food intake as well as lower response to exogenous ghrelin, and a lower plasma ghrelin level after fasting, though which receptor is more important is unknown...
  12. pmc Plasminogen activator inhibitor-1 gene-deficient mice. I. Generation by homologous recombination and characterization
    P Carmeliet
    Whitehead Institute for Biomedical Sciences, Cambridge, Massachusetts 02139 4307
    J Clin Invest 92:2746-55. 1993
    ..PAI-1-/- mice were viable, produced similar sizes of litters as PAI-1+/+ mice, and showed no apparent macroscopic or microscopic histological abnormalities...
  13. pmc Differential body weight and feeding responses to high-fat diets in rats and mice lacking cholecystokinin 1 receptors
    Sheng Bi
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 720 Rutland Ave, Baltimore, MD 21205, USA
    Am J Physiol Regul Integr Comp Physiol 293:R55-63. 2007
    ..Together, these data provide further evidence for differential roles of CCK1 receptors in the controls of food intake and body weight in rats and mice...
  14. pmc Infant satiety depends on transient expression of cholecystokinin-1 receptors on ependymal cells lining the third ventricle in mice
    Tomoya Ozaki
    1Graduate School of Innovative Life Science, University of Toyama, 3190 Gofuku, Toyama 930 8555, Japan
    J Physiol 591:1295-312. 2013
    ..Hence, we demonstrate de novo functions of ependymal CCK-1 receptors and reveal a new aspect of infant satiety-controlling mechanisms...
  15. pmc Abnormal Wnt and PI3Kinase signaling in the malformed intestine of lama5 deficient mice
    Léa Ritie
    INSERM, U682, Strasbourg, France Univ de Strasbourg, France
    PLoS ONE 7:e37710. 2012
    ..Thus deregulated adhesion to laminin-511 may be instrumental in diseases such as human pathologies of the gut where laminin-511 is abnormally expressed as it is shown here...
  16. pmc Cholecystokinin plays a novel protective role in diabetic kidney through anti-inflammatory actions on macrophage: anti-inflammatory effect of cholecystokinin
    Satoshi Miyamoto
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Diabetes 61:897-907. 2012
    ..These results suggest that CCK suppresses the activation of macrophage and expression of proinflammatory genes in diabetic kidney. Our findings may provide a novel strategy of therapy for the early stage of diabetic nephropathy...
  17. pmc Modular genetic control of sexually dimorphic behaviors
    Xiaohong Xu
    Department of Anatomy, University of California, San Francisco, San Francisco, CA 94158, USA
    Cell 148:596-607. 2012
    ..Indeed, we find that mice with targeted disruptions of each of four of these genes (Brs3, Cckar, Irs4, Sytl4) exhibit extremely specific deficits in sex specific behaviors, with single genes controlling the ..
  18. pmc Roles of dorsomedial hypothalamic cholecystokinin signaling in the controls of meal patterns and glucose homeostasis
    Guangjing Zhu
    Department of Physiology and Pathophysiology, Xi an Jiaotong University School of Medicine, Xi an, Shaanxi, 710061, China
    Physiol Behav 105:234-41. 2012
    ..Our study also shows a novel role of DMH CCK signaling in glucose homeostasis...
  19. doi Behavioral and cortical EEG evaluations confirm the roles of both CCKA and CCKB receptors in mouse CCK-induced anxiety
    Heng Li
    Department of Developmental Disorders, National Institute of Mental Health, National Center of Neurology and Psychiatry, 4 1 1 Ogawa Higashi, Kodaira, Tokyo 187 8553, Japan
    Behav Brain Res 237:325-32. 2013
    ..The present study also proposed a possibility that cortical EEG is useful for assessing anxiety...
  20. ncbi New quantitative trait loci that contribute to cholesterol gallstone formation detected in an intercross of CAST/Ei and 129S1/SvImJ inbred mice
    Malcolm A Lyons
    Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Physiol Genomics 14:225-39. 2003
    ..Our work continues to demonstrate the genetic complexity and to elucidate the pathophysiology of cholesterol gallstone formation. It should facilitate the development of new approaches for treating this common human disorder...
  21. ncbi Cholecystokinin-A receptors regulate photic input pathways to the circadian clock
    Takao Shimazoe
    Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
    FASEB J 22:1479-90. 2008
    ..These data indicate a novel function of CCK-A receptors in the nonimage-forming photoreception presumably via amacrine cell-mediated signal transduction pathways...
  22. ncbi Involvement of apolipoprotein A-IV and cholecystokinin1 receptors in exogenous peptide YY3 36-induced stimulation of intestinal feedback
    K L Whited
    Department of Anatomy, Physiology, and Cell Biology, University of California Davis, Davis, CA 95616, USA
    Endocrinology 148:4695-703. 2007
    ..The data suggest a role for apo A-IV and the CCK(1)R in PYY(3-36)-induced activation of the vagal afferent pathway and inhibition of gastric emptying, but this is likely not the pathway mediating the effects of PYY(3-36) on food intake...
  23. ncbi Quantitative trait locus for seizure susceptibility on mouse chromosome 5 confirmed with reciprocal congenic strains
    Thomas N Ferraro
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104 3404, USA
    Physiol Genomics 31:458-62. 2007
    ....
  24. ncbi Estrogen receptor alpha-induced cholecystokinin type A receptor expression in the female mouse pituitary
    Hyun Joon Kim
    Division of Clinical and Reproductive Sciences, Department of Clinical Sciences, University of Kentucky, Lexington, Kentucky 40536, USA
    J Endocrinol 195:393-405. 2007
    ..Taken together, this study finds CCK-AR to be an ERalpha downstream gene in the pituitary and suggests that CCK-AR may play a role in the estrogen sensitization of the pituitary response to GnRH...
  25. ncbi Role of CCK1 and Y2 receptors in activation of hindbrain neurons induced by intragastric administration of bitter taste receptor ligands
    Shuzhen Hao
    Department of Anatomy, Physiology, and Cell Biology, School of Veterinary Medicine, University of California Davis, Davis, CA 95616, USA
    Am J Physiol Regul Integr Comp Physiol 294:R33-8. 2008
    ..T2Rs may regulate GI function via release of regulatory peptides and activation of the vagal reflex pathway...
  26. pmc Profiling CCK-mediated pancreatic growth: the dynamic genetic program and the role of STATs as potential regulators
    Grzegorz T Gurda
    Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan 48109 0622, USA
    Physiol Genomics 44:14-24. 2012
    ....
  27. pmc Effect of ghrelin receptor antagonist on meal patterns in cholecystokinin type 1 receptor null mice
    Jennifer Lee
    Department of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, UC Davis, Davis, CA 95616, USA
    Physiol Behav 103:181-7. 2011
    ..The site of action of ghrelin receptors is unclear, but may involve an increase in expression of CART peptide in VAN in HF-fed CCK₁R⁻/⁻ mice...
  28. doi Identification of integrin-alpha4, Rb1, and syncytin a as murine placental target genes of the transcription factor GCMa/Gcm1
    Steffen Wolfgang Schubert
    Institut fur Biochemie, Emil Fischer Zentrum, Universitat Erlangen Nurnberg, Fahrstr 17, D 91054 Erlangen, Germany
    J Biol Chem 283:5460-5. 2008
    ..5. Our data demonstrate for the first time that genes encoding key regulators of placental tissue formation and architecture are regulated by GCMa...
  29. pmc Peptidergic influences on proliferation, migration, and placement of neural progenitors in the adult mouse forebrain
    Davor Stanic
    Department of Neuroscience, Karolinska Institutet, S 17177 Stockholm, Sweden
    Proc Natl Acad Sci U S A 105:3610-5. 2008
    ..These findings suggest that both NPY and CCK through their receptors help to regulate the proliferation of precursor cells, the amount of neuroblast cells in the SVZ and RMS, and influence the differentiation of OB interneurons...
  30. doi Gastric acid secretion in cholecystokinin-1 receptor, -2 receptor, and -1, -2 receptor gene knockout mice
    Setsuko Kanai
    Department of Clinical Physiology, Tokyo Metropolitan Institute of Gerontology, Itabashi ku, Tokyo, 173 0015, Japan
    J Physiol Sci 59:23-9. 2009
    ..In conclusion, CCK-2R is necessary to respond to carbachol as well as to produce the maximal acid secretion, while the role of CCK-1R in acid secretion is less important...
  31. ncbi Cholecystokinin directly inhibits neuronal activity of primary gonadotropin-releasing hormone cells through cholecystokinin-1 receptor
    Paolo Giacobini
    Cellular and Developmental Neurobiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 3714, USA
    Endocrinology 148:63-71. 2007
    ..This study provides evidence that CCK acts directly on GnRH-1 neurons to attenuate GnRH-1 neuronal activity via CCK-1R activation...
  32. pmc Identification and characterization of the STIM (stromal interaction molecule) gene family: coding for a novel class of transmembrane proteins
    R T Williams
    Department of Anatomy and Cell Biology, University of Melbourne, Parkville, Victoria 3052, Australia
    Biochem J 357:673-85. 2001
    ..This association into oligomers in vivo indicates a possible functional interaction between STIM1 and STIM2. The structural similarities between STIM1, STIM2 and D-STIM suggest conserved biological functions...
  33. ncbi Localization of the murine cholecystokinin A and B receptor genes
    L C Samuelson
    Department of Physiology, University of Michigan, Ann Arbor 48109 0622, USA
    Mamm Genome 6:242-6. 1995
    ..The CCKA receptor gene (Cckar) mapped to mouse Chromosome (Chr) 5, in tight linkage with the DNA marker D5Bir8...
  34. ncbi Species differences between rat and mouse CCKA receptors determine the divergent acinar cell response to the cholecystokinin analog JMV-180
    B Ji
    Department of Physiology, University of Michigan, Ann Arbor, Michigan 48109 0622 and Tupper Research Institute, New England Medical Center, Boston, Massachusetts 02111, USA
    J Biol Chem 275:19115-20. 2000
    ..These data suggest that species differences in the CCK(A) receptor of rats and mice account for the observed divergence in the acinar cell response to JMV-180...
  35. ncbi Analyses of proteins involved in vesicular trafficking in platelets of mouse models of Hermansky Pudlak syndrome
    B Richards-Smith
    Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Mol Genet Metab 68:14-23. 1999
    ..The Snap23 gene was mapped to mouse chromosome 5, demonstrating it cannot encode the gm gene, which maps to chromosome 14. It is likely therefore that the gm gene functions upstream of SNAP-23 in vesicular trafficking...
  36. pmc The cholecystokinin-A receptor mediates inhibition of food intake yet is not essential for the maintenance of body weight
    A S Kopin
    Department of Medicine, GRASP Digestive Disease Center, Tupper Research Institute, New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    J Clin Invest 103:383-91. 1999
    ..Our results suggest that although cholecystokinin plays a role in the short-term inhibition of food intake, this pathway is not essential for the long-term maintenance of body weight...
  37. ncbi Extension of conserved regions in the rat and mouse genomes by chromosomal assignments of 29 rat genes
    Z Cui
    Institute of Laboratory Animals, Faculty of Medicine, Kyoto University, Japan
    Exp Anim 47:83-8. 1998
    ..In addition, four conserved regions were newly revealed. The method described in this study appears to be simple and efficient for constructing a whole genome comparative map of the rat and mouse...
  38. ncbi Mouse cholecystokinin type-A receptor gene and its structural analysis
    Y Takata
    Division of Chemotherapy, National Kyushu Cancer Center, Fukuoka, Japan
    Gene 187:267-71. 1997
    ..The shorter isoform may encode an 48 amino acid open reading frame due to frameshift of translation. These two mRNA isoforms were expressed equally in the mouse gallbladders...
  39. ncbi Genomic organization and chromosomal localization of the mouse Bp3 gene, a member of the CD38/ADP-ribosyl cyclase family
    C Dong
    University of Alabama at Birmingham, 378 WTI, 1824 6th Avenue South, Birmingham, AL 35294, USA
    Immunogenetics 45:35-43. 1996
    ..Consensus motifs for cytokine responsive factors NF-IL6/C-EBP, H-APF-1/APRF, and AP-1 are also present in the flanking region, and interleukin-6 treatment enhances expression of the Bp3 antigen by a myeloblastoid cell line...
  40. pmc The bHLH transcription factor Mist1 is required to maintain exocrine pancreas cell organization and acinar cell identity
    C L Pin
    Department of Paediatrics, Child Health Research Institute, University of Western Ontario, London, Ontario N6C 2V5, Canada
    J Cell Biol 155:519-30. 2001
    ..Based on these observations, we propose that Mist1(KO) mice represent a new genetic model for chronic pancreas injury and that the Mist1 protein serves as a key regulator of acinar cell function, stability, and identity...
  41. ncbi Anxiety-related behaviors in cholecystokinin-A, B, and AB receptor gene knockout mice in the plus-maze
    Kyoko Miyasaka
    Department of Clinical Physiology, Tokyo Metropolitan Institute of Gerontology, 35 2 Sakaecho Itabashiku, l73 0015, Tokyo, Japan
    Neurosci Lett 335:115-8. 2002
    ..We therefore conclude that a lack of CCK-BR increases the anxiety-related behavior of the mouse in the elevated plus- maze...
  42. ncbi Association of cholecystokinin A receptor gene polymorphism with cholelithiasis and the molecular mechanisms of this polymorphism
    Kyoko Miyasaka
    Department of Clinical Physiology, Tokyo Metropolitan Institute of Gerontology, 35 2 Sakaecho, Itabashiku, Tokyo 173 0015, Japan
    J Gastroenterol 37:102-6. 2002
    ..The involvement of CCK-AR in gallstone formation was confirmed using CCK-AR gene knockout mice...
  43. ncbi Targeted disruption of the murine CCK1 receptor gene reduces intestinal lipid-induced feedback inhibition of gastric function
    K L Whited
    Department of Anatomy, Physiology, and Cell Biology, School of Vetinary Medicine, University of California, Davis School of Veterinary Medicine, Davis, CA 95616, USA
    Am J Physiol Gastrointest Liver Physiol 291:G156-62. 2006
    ..Thus, despite a relatively normal phenotype, intestinal feedback in response to lipid is severely impaired in these mice...
  44. pmc Cholecystokinin 1 receptor modulates the MEKK1-induced c-Jun trans-activation: structural requirements of the receptor
    Géraldine Ibarz
    Laboratoire des Aminoacides, Peptides et Protéines LAPP, CNRS UMR 5810, UMI et UMII, UFR Pharmacie, 15, Avenue Charles Flahault, 34093 Montpellier Cedex 5, France
    Br J Pharmacol 147:951-8. 2006
    In cells overexpressing active MEKK1 to enhance c-Jun trans-activation, expression of rat cholecystokinin 1 receptor increased the activity of c-Jun while in the same experimental conditions overexpression of mouse cholecystokinin 1 ..
  45. ncbi Cholecystokinin activates orexin/hypocretin neurons through the cholecystokinin A receptor
    Natsuko Tsujino
    Department of Molecular Pharmacology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki 305 8575, Japan
    J Neurosci 25:7459-69. 2005
    ..The evidence presented here expands our understanding of the regulation of orexin neurons and the physiological role of CCK in the CNS...
  46. ncbi Differences in partial agonist action at cholecystokinin receptors of mouse and rat are dependent on parameters extrinsic to receptor structure: molecular cloning, expression and functional characterization of the mouse type A cholecystokinin receptor
    D Ghanekar
    Center for Basic Research in Digestive Diseases, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    J Pharmacol Exp Ther 282:1206-12. 1997
    ..Receptor microenvironment makes an important, yet often ignored, contribution to receptor function...
  47. ncbi Absence of the cholecystokinin-A receptor deteriorates homeostasis of body temperature in response to changes in ambient temperature
    Shigeki Nomoto
    Department of Clinical Physiology, Tokyo Metropolitan Institute of Gerontology, 35 2 Sakaecho, Itabashiku Tokyo 173 0015, Japan
    Am J Physiol Regul Integr Comp Physiol 287:R556-61. 2004
    ..Mice without CCK-AR showed larger hysteresis than mice with CCK-AR. From these results, we conclude that the lack of CCK-AR causes homeostasis of T(c) in rats and mice to deteriorate...
  48. ncbi Enhanced gastric emptying of a liquid gastric load in mice lacking cholecystokinin-B receptor: a study of CCK-A,B, and AB receptor gene knockout mice
    Kyoko Miyasaka
    Department of Clinical Physiology, Tokyo Metropolitan Institute of Gerontology, 35 2 Sakaecho, Itabashi ku, Tokyo, 173 0015, Japan
    J Gastroenterol 39:319-23. 2004
    ..We examined whether gastric emptying of a nonnutrient liquid load was modified in CCK-AR, BR, and ARBR gene knockout mice...
  49. ncbi Differential roles for cholecystokinin a receptors in energy balance in rats and mice
    Sheng Bi
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Endocrinology 145:3873-80. 2004
    ..The deficit in CCK's action in the control of DMH NPY gene expression may play a major role in the obese phenotype in OLETF rats...
  50. ncbi Lack of cholecystokinin-A receptor enhanced gallstone formation: a study in CCK-A receptor gene knockout mice
    Norikazu Sato
    Department of Clinical Physiology, Tokyo Metropolitan Institute of Gerontology, 35 2 Sakaecho, Itabashiku, Tokyo 173 0015, Japan
    Dig Dis Sci 48:1944-7. 2003
    ..Sludge and gallstone formation were not observed at 6 months of age. In conclusion, deteriorated gallbladder contraction due to a lack of CCK-AR favored gallstone formation after the middle age of life...
  51. ncbi Chromosomal localization of the gastric and brain receptors for cholecystokinin (CCKAR and CCKBR) in human and mouse
    K Huppi
    Molecular Genetics Section, Laboratory of Genetics, NCI NIH, Bethesda, Maryland 20892, USA
    Genomics 25:727-9. 1995
    Receptors for cholcystokinin (CCK) can be pharmacologically classified into at least two distinct subtypes, CCKAR and CCKBR...

Research Grants19

  1. Exercise and energy balance: role of hypothalamic transthyretin
    Sheng Bi; Fiscal Year: 2010
    ..Such identification will provide a potential target for the prevention and treatment of obesity. ..
  2. Dorsomedial Hypothalamic Pathways and Energy Balance
    Sheng Bi; Fiscal Year: 2005
    ..Together, these neurochemical and functional demonstrations will provide a clear view of the role of the DMH in energy balance ..
  3. Dorsomedial Hypothalamic Signaling Pathways and Energy Balance
    Sheng Bi; Fiscal Year: 2010
    ..Overall, the elucidation of the actions of these DMH peptide systems in feeding and body weight control would significantly advance our understanding of the role of this hypothalamic nucleus in maintaining energy homeostasis. ..
  4. Dorsomedial Hypothalamic Signaling Pathways and Energy Balance
    Sheng Bi; Fiscal Year: 2010
    ..Overall, the elucidation of the actions of these DMH peptide systems in feeding and body weight control would significantly advance our understanding of the role of this hypothalamic nucleus in maintaining energy homeostasis. ..
  5. QUANTITATIVE GENETIC STUDY OF SEIZURES
    Thomas N Ferraro; Fiscal Year: 2010
    ....
  6. QUANTITATIVE GENETIC STUDY OF SEIZURES
    THOMAS FERRARO; Fiscal Year: 2007
    ..abstract_text> ..
  7. PHARMACOGENOMIC STUDY OF ANTICONVULSANT THERAPY
    THOMAS FERRARO; Fiscal Year: 2003
    ....
  8. QUANTITATIVE GENETIC STUDY OF SEIZURES
    THOMAS FERRARO; Fiscal Year: 2002
    ..Hopefully, these findings will lead as well to new and important information regarding the pathogenesis of human epilepsy. ..