Gene Symbol: Cck
Description: cholecystokinin
Alias: cholecystokinin
Species: mouse
Products:     Cck

Top Publications

  1. Friedman J, Schneider B, Barton D, Francke U. Level of expression and chromosome mapping of the mouse cholecystokinin gene: implications for murine models of genetic obesity. Genomics. 1989;5:463-9 pubmed
    b>Cholecystokinin (CCK) is a neuropeptide which is present in brain and intestine and which stimulates gall bladder contraction and pancreatic secretion. Additional studies have demonstrated an appetite-suppressing effect of CCK in vivo...
  2. Nagata E, Nakagawa Y, Yamaguchi R, Fujisawa Y, Sano S, Satake E, et al. Altered gene expressions of ghrelin, PYY, and CCK in the gastrointestinal tract of the hyperphagic intrauterine growth restriction rat offspring. Horm Metab Res. 2011;43:178-82 pubmed publisher
    ..We examined the food intake and assessed the gene expressions of ghrelin, peptide YY (PYY), and cholecystokinin (CCK) in the alimentary tract of male newborns (postnatal day1) and adult offspring (age, 7 months)...
  3. Lo C, King A, Samuelson L, KINDEL T, Rider T, Jandacek R, et al. Cholecystokinin knockout mice are resistant to high-fat diet-induced obesity. Gastroenterology. 2010;138:1997-2005 pubmed publisher
    b>Cholecystokinin (CCK) is a satiation peptide released during meals in response to lipid intake; it regulates pancreatic digestive enzymes that are required for absorption of nutrients...
  4. Mellitzer G, Beucher A, Lobstein V, Michel P, Robine S, Kedinger M, et al. Loss of enteroendocrine cells in mice alters lipid absorption and glucose homeostasis and impairs postnatal survival. J Clin Invest. 2010;120:1708-21 pubmed publisher
    ..Our data help unravel the role of enteroendocrine cells and hormones in lipid absorption and maintenance of the intestinal epithelium. ..
  5. Taniguchi H, He M, Wu P, Kim S, Paik R, Sugino K, et al. A resource of Cre driver lines for genetic targeting of GABAergic neurons in cerebral cortex. Neuron. 2011;71:995-1013 pubmed publisher
    ..As such, this approach will accelerate the study of GABAergic circuits throughout the mammalian brain. ..
  6. Offield M, Jetton T, Labosky P, Ray M, Stein R, Magnuson M, et al. PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum. Development. 1996;122:983-95 pubmed
    ..These results offer additional insight into the role of pdx-1 in the determination and differentiation of the posterior foregut, particularly regarding the proliferation and differentiation of the pancreatic progenitors. ..
  7. Lo C, Samuelson L, Chambers J, King A, Heiman J, Jandacek R, et al. Characterization of mice lacking the gene for cholecystokinin. Am J Physiol Regul Integr Comp Physiol. 2008;294:R803-10 pubmed
    b>CCK acts peripherally as a satiating peptide released during meals in response to lipid feeding and centrally functions in the modulation of feeding, exploratory, and memory activities...
  8. Lay J, Gillespie P, Samuelson L. Murine prenatal expression of cholecystokinin in neural crest, enteric neurons, and enteroendocrine cells. Dev Dyn. 1999;216:190-200 pubmed
    b>Cholecystokinin (CCK) is a regulatory peptide that is primarily expressed in two adult cell types: endocrine cells of the intestine and neurons of the central nervous system...
  9. Lacourse K, Swanberg L, Gillespie P, Rehfeld J, Saunders T, Samuelson L. Pancreatic function in CCK-deficient mice: adaptation to dietary protein does not require CCK. Am J Physiol. 1999;276:G1302-9 pubmed
    A CCK-deficient mouse mutant generated by gene targeting in embryonic stem cells was analyzed to determine the importance of CCK for growth and function of the exocrine pancreas and for pancreatic adaptation to dietary changes...

More Information


  1. Garfield A, Patterson C, Skora S, Gribble F, Reimann F, Evans M, et al. Neurochemical characterization of body weight-regulating leptin receptor neurons in the nucleus of the solitary tract. Endocrinology. 2012;153:4600-7 pubmed fluorescent protein (EGFP) transgene and distinct populations that express proglucagon and/or cholecystokinin. The significance of leptin action on these three populations of NTS neurons was assessed in leptin-deficient ..
  2. Jenny M, Uhl C, Roche C, Duluc I, Guillermin V, Guillemot F, et al. Neurogenin3 is differentially required for endocrine cell fate specification in the intestinal and gastric epithelium. EMBO J. 2002;21:6338-47 pubmed
    ..Thus, ngn3 is strictly required for endocrine cell fate specification in multipotent intestinal progenitor cells, whereas gastric endocrine development is both ngn3 dependent and independent. ..
  3. Giacobini P, Kopin A, Beart P, Mercer L, Fasolo A, Wray S. Cholecystokinin modulates migration of gonadotropin-releasing hormone-1 neurons. J Neurosci. 2004;24:4737-48 pubmed
    Expression of the brain-gut peptide cholecystokinin (CCK) in the developing olfactory-gonadotropin-releasing hormone-1 (GnRH-1) neuroendocrine systems was characterized, and the function of CCK in these systems was analyzed both in vivo ..
  4. Maletinska L, Toma R, Pirnik Z, Kiss A, Slaninova J, Haluzik M, et al. Effect of cholecystokinin on feeding is attenuated in monosodium glutamate obese mice. Regul Pept. 2006;136:58-63 pubmed
    ..After fasting, the MSG-treated mice showed attenuated food intake compared to controls. Cholecystokinin octapeptide, which decreased food intake in a dose-dependent manner in 24 h fasted controls, did not ..
  5. Du A, McCracken K, Walp E, Terry N, Klein T, Han A, et al. Arx is required for normal enteroendocrine cell development in mice and humans. Dev Biol. 2012;365:175-88 pubmed publisher
    ..the developing endoderm results in a decrease of enteroendocrine cell types including gastrin-, glucagon/GLP-1-, CCK-, secretin-producing cell populations and an increase of somatostatin-expressing cells...
  6. Ramalho Santos M, Melton D, McMahon A. Hedgehog signals regulate multiple aspects of gastrointestinal development. Development. 2000;127:2763-72 pubmed
    ..These results show that Hedgehog signals are essential for organogenesis of the mammalian gastrointestinal tract and suggest that mutations in members of this signaling pathway may be involved in human gastrointestinal malformations. ..
  7. Irwin N, Pathak V, Flatt P. A Novel CCK-8/GLP-1 Hybrid Peptide Exhibiting Prominent Insulinotropic, Glucose-Lowering, and Satiety Actions With Significant Therapeutic Potential in High-Fat-Fed Mice. Diabetes. 2015;64:2996-3009 pubmed publisher
    Glucagon-like peptide-1 (GLP-1) and cholecystokinin (CCK) exert important complementary beneficial metabolic effects...
  8. Cao S, Wu W, Han Z, Wang M. Effects of psychological stress on small intestinal motility and expression of cholecystokinin and vasoactive intestinal polypeptide in plasma and small intestine in mice. World J Gastroenterol. 2005;11:737-40 pubmed
    To investigate the effects of psychological stress on small intestinal motility and expression of cholecystokinin (CCK) and vasoactive intestinal polypeptide (VIP) in plasma and small intestine, and to explore the relationship between ..
  9. Rehfeld J, Bungaard J, Friis Hansen L, Goetze J. On the tissue-specific processing of procholecystokinin in the brain and gut--a short review. J Physiol Pharmacol. 2003;54 Suppl 4:73-9 pubmed
    b>Cholecystokinin (CCK) is a major peptide hormone in the gut and a major peptide transmitter in the brain. Its synthesis requires endoproteolytic cleavage of proCCK at several mono- and dibasic sites by prohormone convertases (PCs)...
  10. Meziane H, Devigne C, Tramu G, Soumireu Mourat B. Distribution of cholecystokinin immunoreactivity in the BALB/c mouse forebrain: an immunocytochemical study. J Chem Neuroanat. 1997;12:191-209 pubmed
    The present study describes cholecystokinin (CCK) immunoreactivity (CCK-IR) distribution in the brains of control and colchicine-treated mice. In the brains of control mice, the CCK-IR strongly revealed numerous axons and terminals...
  11. Cain B, Wang W, Beinfeld M. Cholecystokinin (CCK) levels are greatly reduced in the brains but not the duodenums of Cpe(fat)/Cpe(fat) mice: a regional difference in the involvement of carboxypeptidase E (Cpe) in pro-CCK processing. Endocrinology. 1997;138:4034-7 pubmed
    In order to assess the possible role of carboxypeptidase E (Cpe) in pro-CCK processing, tissues from the Cpe(fat)/Cpe(fat) mice were analyzed for CCK content and molecular forms using specific RIAs directed against different portions of ..
  12. Matsui K, Masui A, Kato N, Adachi K. Levels of somatostatin and cholecystokinin in the brain of ataxic mutant mice. Life Sci. 1993;53:333-40 pubmed
    Changes in immunoreactive somatostatin (SOM) and cholecystokinin (CCK-8) levels in the cerebellum and cerebrum were investigated in three types of genetically-determined ataxic mutant mice: rolling mouse Nagoya (RMN), weaver, and ..
  13. Xu Y, Lopes C, Qian Y, Liu Y, Cheng L, Goulding M, et al. Tlx1 and Tlx3 coordinate specification of dorsal horn pain-modulatory peptidergic neurons. J Neurosci. 2008;28:4037-46 pubmed publisher
    ..overlapping expression of a set of neuropeptide genes, including those encoding the anti-opioid peptide cholecystokinin, pronociceptive Substance P (SP), Neurokinin B, and a late wave of somatostatin...
  14. Beinfeld M, Blum A, Vishnuvardhan D, Fanous S, Marchand J. Cholecystokinin levels in prohormone convertase 2 knock-out mouse brain regions reveal a complex phenotype of region-specific alterations. J Biol Chem. 2005;280:38410-5 pubmed
    Prohormone convertase 2 is widely co-localized with cholecystokinin in rodent brain...
  15. Mollet A, Meier S, Grabler V, Gilg S, Scharrer E, Lutz T. Endogenous amylin contributes to the anorectic effects of cholecystokinin and bombesin. Peptides. 2003;24:91-8 pubmed
    Previous studies indicated that amylin contributes to the anorectic effects of cholecystokinin (CCK) and bombesin (BBS), possibly by enhancing the release of pancreatic amylin or by modulating their anorectic actions within the central ..
  16. Zhou L, Yang H, Okoro E, Guo Z. Up-regulation of cholesterol absorption is a mechanism for cholecystokinin-induced hypercholesterolemia. J Biol Chem. 2014;289:12989-99 pubmed publisher
    ..This report examines the effect of cholecystokinin (CCK) on plasma cholesterol level and intestinal cholesterol absorption using the in vivo models of C57BL/6 ..
  17. Santofimia Castaño P, Ruy D, Fernandez Bermejo M, Salido G, Gonzalez A. Pharmacological dose of melatonin reduces cytosolic calcium load in response to cholecystokinin in mouse pancreatic acinar cells. Mol Cell Biochem. 2014;397:75-86 pubmed publisher
    ..In this study, the effects of melatonin on Ca(2+) mobilization induced by cholecystokinin octapeptide (CCK-8) in freshly isolated mouse pancreatic acinar cells have been examined...
  18. Hand K, Bruen C, O Halloran F, Giblin L, Green B. Acute and chronic effects of dietary fatty acids on cholecystokinin expression, storage and secretion in enteroendocrine STC-1 cells. Mol Nutr Food Res. 2010;54 Suppl 1:S93-S103 pubmed publisher
    b>Cholecystokinin (CCK) is a peptide hormone secreted from the I-cells of the intestine and it has important physiological actions related to appetite regulation and satiety...
  19. Gallo R, Kim K, Bernfield M, Kozak C, Zanetti M, Merluzzi L, et al. Identification of CRAMP, a cathelin-related antimicrobial peptide expressed in the embryonic and adult mouse. J Biol Chem. 1997;272:13088-93 pubmed
    ..These data suggest that inflammatory cells in the mouse can use a nonoxidative mechanism for microbial killing and permit use of the mouse to study the role such peptides play in host defense and wound repair. ..
  20. Calvigioni D, Mate Z, Fuzik J, Girach F, Zhang M, Varro A, et al. Functional Differentiation of Cholecystokinin-Containing Interneurons Destined for the Cerebral Cortex. Cereb Cortex. 2017;27:2453-2468 pubmed publisher
    Although extensively studied postnatally, the functional differentiation of cholecystokinin (CCK)-containing interneurons en route towards the cerebral cortex during fetal development is incompletely understood...
  21. Seah C, Levy M, Jiang Y, Mokhtarzada S, Higgs D, Gibbons R, et al. Neuronal death resulting from targeted disruption of the Snf2 protein ATRX is mediated by p53. J Neurosci. 2008;28:12570-80 pubmed publisher
    ..Together, these findings show that ATRX deficiency leads to p53-dependent neuronal apoptosis which is responsible for some but not all of the phenotypic consequences of ATRX deficiency in the forebrain. ..
  22. Zhang Y, Zhu J, Guo L, Zou Y, Wang F, Shao H, et al. Cholecystokinin protects mouse liver against ischemia and reperfusion injury. Int Immunopharmacol. 2017;48:180-186 pubmed publisher
    b>Cholecystokinin (CCK), as a gastrointestinal hormone, has an important protective role against sepsis or LPS-induced endotoxic shock. We aim to address the role of CCK in hepatic ischemia followed by reperfusion (I/R) injury...
  23. Ramesh N, Mortazavi S, Unniappan S. Nesfatin-1 stimulates cholecystokinin and suppresses peptide YY expression and secretion in mice. Biochem Biophys Res Commun. 2016;472:201-8 pubmed publisher
    ..Intestine is a source of additional hormones including cholecystokinin (CCK) and peptide YY (PYY) that regulate metabolism...
  24. Jinno S, Kosaka T. Patterns of expression of neuropeptides in GABAergic nonprincipal neurons in the mouse hippocampus: Quantitative analysis with optical disector. J Comp Neurol. 2003;461:333-49 pubmed
    ..This study shows the patterns of expression of four neuropeptides [neuropeptide Y (NPY), somatostatin (SOM), cholecystokinin (CCK), and vasoactive intestinal polypeptide (VIP)] in gamma-aminobutyric acid (GABA)-ergic neurons of the ..
  25. Severson K, Xu D, Van de Loo M, Bai L, Ginty D, O Connor D. Active Touch and Self-Motion Encoding by Merkel Cell-Associated Afferents. Neuron. 2017;94:666-676.e9 pubmed publisher
    ..Thus, Merkel afferents send to the brain multiplexed information about whisker position and surface features, suggesting that proprioception and touch converge at the earliest neural level. ..
  26. Chung S, Weber F, Zhong P, Tan C, Nguyen T, BEIER K, et al. Identification of preoptic sleep neurons using retrograde labelling and gene profiling. Nature. 2017;545:477-481 pubmed publisher
    ..these neurons, and optogenetic and pharmacogenetic manipulations demonstrate that several peptide markers (cholecystokinin, corticotropin-releasing hormone, and tachykinin 1) label sleep-promoting neurons...
  27. Soriano E, Del Rio J, Martinez A, Super H. Organization of the embryonic and early postnatal murine hippocampus. I. Immunocytochemical characterization of neuronal populations in the subplate and marginal zone. J Comp Neurol. 1994;342:571-95 pubmed
    ..It is suggested that these early maturing neurons may have a role in the targeting of hippocampal afferents, as subplate cells do in the developing neocortex. ..
  28. Lavine J, Raess P, Stapleton D, Rabaglia M, Suhonen J, Schueler K, et al. Cholecystokinin is up-regulated in obese mouse islets and expands beta-cell mass by increasing beta-cell survival. Endocrinology. 2010;151:3577-88 pubmed publisher
    ..We previously reported that cholecystokinin (Cck) was the most up-regulated gene in obese pancreatic islets...
  29. Beinfeld M. Biosynthesis and processing of pro CCK: recent progress and future challenges. Life Sci. 2003;72:747-57 pubmed
    Pro Cholecystokinin (CCK) like other prohormones that pass through the regulated secretory pathway, undergoes a number of post-translational modifications during its biosynthesis including tyrosine sulfation, endoproteolytic cleavages, ..
  30. Boyer D, Fujitani Y, Gannon M, Powers A, Stein R, Wright C. Complementation rescue of Pdx1 null phenotype demonstrates distinct roles of proximal and distal cis-regulatory sequences in pancreatic and duodenal expression. Dev Biol. 2006;298:616-31 pubmed
    ..These results reveal a role for distal cis-regulatory elements in achieving the correct level of extra-pancreatic Pdx1 expression, which is necessary for the production of duodenal GIP cells and stomach gastrin cells. ..
  31. Vitale M, Vashishtha A, Linzer E, Powell D, Friedman J. Molecular cloning of the mouse CCK gene: expression in different brain regions and during cortical development. Nucleic Acids Res. 1991;19:169-77 pubmed
    In this paper we describe experiments that address specific issues concerning the regulation of the mouse cholecystokinin gene in brain and intestine. The mouse cholecystokinin gene was cloned and sequenced...
  32. Nash S, Giros B, Kingsmore S, Kim K, El Mestikawy S, Dong Q, et al. Cloning, gene structure and genomic localization of an orphan transporter from mouse kidney with six alternatively-spliced isoforms. Receptors Channels. 1998;6:113-28 pubmed
  33. Abraira V, Kuehn E, Chirila A, Springel M, Toliver A, Zimmerman A, et al. The Cellular and Synaptic Architecture of the Mechanosensory Dorsal Horn. Cell. 2017;168:295-310.e19 pubmed publisher
    ..Thus, the LTMR-RZ is a somatosensory processing region endowed with a neuronal complexity that rivals the retina and functions to pattern the activity of ascending touch pathways that underlie tactile perception. ..
  34. Demenis C, McLaughlin J, Smith C. Sulfated Cholecystokinin-8 Promotes CD36-Mediated Fatty Acid Uptake into Primary Mouse Duodenal Enterocytes. Front Physiol. 2017;8:660 pubmed publisher
    b>Cholecystokinin (CCK) is an archetypal incretin hormone secreted by intestinal enteroendocrine cells (EEC) in response to ingested nutrients...
  35. Okazaki T, Yoshida B, Avraham K, Wang H, Wuenschell C, Jenkins N, et al. Molecular diversity of the SCG10/stathmin gene family in the mouse. Genomics. 1993;18:360-73 pubmed
    ..These data are consistent with the idea that the neuron-specific SCG10 gene evolved by duplication and modification of the more broadly expressed stathmin/Lap18 gene. ..
  36. Young H, Jenkins N, Copeland N, Simek S, Lerman M, Zbar B, et al. Localization of a novel natural killer triggering receptor locus to human chromosome 3p23-p21 and mouse chromosome 9. Genomics. 1993;16:548-9 pubmed
  37. Maksimovic S, Nakatani M, Baba Y, Nelson A, Marshall K, Wellnitz S, et al. Epidermal Merkel cells are mechanosensory cells that tune mammalian touch receptors. Nature. 2014;509:617-21 pubmed publisher
    ..Thus, the Merkel cell-neurite complex is an unique sensory structure composed of two different receptor cell types specialized for distinct elements of discriminative touch. ..
  38. Hisadome K, Reimann F, Gribble F, Trapp S. CCK stimulation of GLP-1 neurons involves α1-adrenoceptor-mediated increase in glutamatergic synaptic inputs. Diabetes. 2011;60:2701-9 pubmed publisher
    ..Another satiety hormone, cholecystokinin (CCK), has also been linked to activation of brain stem neurons, suggesting that it might act partially via ..
  39. Bröhl D, Strehle M, Wende H, Hori K, Bormuth I, Nave K, et al. A transcriptional network coordinately determines transmitter and peptidergic fate in the dorsal spinal cord. Dev Biol. 2008;322:381-93 pubmed publisher
    ..We conclude that a transcriptional network operates in maturing dorsal horn neurons that coordinately determines transmitter and peptidergic fate. ..
  40. Del Rio J, Martinez A, Auladell C, Soriano E. Developmental history of the subplate and developing white matter in the murine neocortex. Neuronal organization and relationship with the main afferent systems at embryonic and perinatal stages. Cereb Cortex. 2000;10:784-801 pubmed
  41. King A, Yang Q, Huesman S, Rider T, Lo C. Lipid transport in cholecystokinin knockout mice. Physiol Behav. 2015;151:198-206 pubmed publisher
    b>Cholecystokinin (CCK) is released in response to lipid feeding and regulates pancreatic digestive enzymes vital to the absorption of nutrients...
  42. Zhu H, Cabrera R, Wlodarczyk B, Bozinov D, Wang D, Schwartz R, et al. Differentially expressed genes in embryonic cardiac tissues of mice lacking Folr1 gene activity. BMC Dev Biol. 2007;7:128 pubmed
    ..These changes affected normal cytoskeleton structures, cell migration and motility as well as cellular redox status, which may contribute to cardiovascular abnormalities in mouse embryos lacking Folr1 gene activity. ..
  43. Schwarz M, Davis D, Vick B, Russell D. Genetic analysis of cholesterol accumulation in inbred mice. J Lipid Res. 2001;42:1812-9 pubmed
    ..We conclude that a large number of genes affects the amount of cholesterol absorbed in the small intestine and its accumulation in the liver and plasma of inbred mice. ..
  44. Giacobini P, Wray S. Prenatal expression of cholecystokinin (CCK) in the central nervous system (CNS) of mouse. Neurosci Lett. 2008;438:96-101 pubmed publisher
    b>Cholecystokinin (CCK) is a peptide found in both gut and brain. Although numerous studies address the role of brain CCK postnatally, relatively little is known about the ontogeny of CCK expression in the central nervous system (CNS)...
  45. Tien N, Soto F, Kerschensteiner D. Homeostatic Plasticity Shapes Cell-Type-Specific Wiring in the Retina. Neuron. 2017;94:656-665.e4 pubmed publisher
  46. Wang H, Portincasa P, Liu M, Tso P, Samuelson L, Wang D. Effect of gallbladder hypomotility on cholesterol crystallization and growth in CCK-deficient mice. Biochim Biophys Acta. 2010;1801:138-46 pubmed publisher
    ..gallbladder hypomotility on cholesterol crystallization and growth during the early stage of gallstone formation in CCK knockout mice...
  47. Liu G, Pakala S, Gu D, Krahl T, Mocnik L, Sarvetnick N. Cholecystokinin expression in the developing and regenerating pancreas and intestine. J Endocrinol. 2001;169:233-40 pubmed
    ..Little is known about the involvement of cholecystokinin (CCK), a gut hormone, involved in regulating the secretion of pancreatic hormones, and pancreatic growth...
  48. Holz A, Frank M, Copeland N, Gilbert D, Jenkins N, Schwab M. Chromosomal localization of the myelin-associated oligodendrocytic basic protein and expression in the genetically linked neurological mouse mutants ducky and tippy. J Neurochem. 1997;69:1801-9 pubmed
    ..Our results suggest that alterations in the Mobp gene are not the cause for the severe neurological phenotypes of ducky and tippy mice. ..
  49. Li Q, Deng X, Singh P. Significant increase in the aggressive behavior of transgenic mice overexpressing peripheral progastrin peptides: associated changes in CCK2 and serotonin receptors in the CNS. Neuropsychopharmacology. 2007;32:1813-21 pubmed
    ..As CCK, CCK(2) receptors (CCK(2)R), and 5-HT(1A) receptors (5-HT(1A)R) in the CNS play an important role in these ..
  50. Sankoda A, Harada N, Iwasaki K, Yamane S, Murata Y, Shibue K, et al. Long-Chain Free Fatty Acid Receptor GPR120 Mediates Oil-Induced GIP Secretion Through CCK in Male Mice. Endocrinology. 2017;158:1172-1180 pubmed publisher
    ..GPR120-/- and GPR40-/- mice also exhibited substantially decreased levels of cholecystokinin (CCK), a hormone from I cells that promotes bile and pancreatic lipase secretion, and this decrease was ..
  51. Basu J, Zaremba J, Cheung S, Hitti F, Zemelman B, Losonczy A, et al. Gating of hippocampal activity, plasticity, and memory by entorhinal cortex long-range inhibition. Science. 2016;351:aaa5694 pubmed publisher
    ..Long-range inhibition from entorhinal cortex may thus increase the precision of hippocampal-based long-term memory associations by assessing the salience of mnemonormation to the immediate sensory input. ..
  52. Piccand J, Meunier A, Merle C, Jia Z, Barnier J, Gradwohl G. Pak3 promotes cell cycle exit and differentiation of ?-cells in the embryonic pancreas and is necessary to maintain glucose homeostasis in adult mice. Diabetes. 2014;63:203-15 pubmed publisher
    ..In the adult, Pak3 is required for the proper control of glucose homeostasis under challenging HFD. ..
  53. López Díaz L, Jain R, Keeley T, VanDussen K, Brunkan C, Gumucio D, et al. Intestinal Neurogenin 3 directs differentiation of a bipotential secretory progenitor to endocrine cell rather than goblet cell fate. Dev Biol. 2007;309:298-305 pubmed
    ..Thus, our data suggest that Neurogenin 3 can redirect the differentiation of bipotential secretory progenitors to endocrine rather than goblet cell fate. ..
  54. Del Boca C, Lutz P, le Merrer J, Koebel P, Kieffer B. Cholecystokinin knock-down in the basolateral amygdala has anxiolytic and antidepressant-like effects in mice. Neuroscience. 2012;218:185-95 pubmed publisher
    b>Cholecystokinin (CCK) is a neuropeptide widely distributed in the mammalian brain...
  55. Sykaras A, Demenis C, Cheng L, Pisitkun T, McLaughlin J, Fenton R, et al. Duodenal CCK cells from male mice express multiple hormones including ghrelin. Endocrinology. 2014;155:3339-51 pubmed publisher
    ..I cells represent a subset of EEC cells that secrete cholecystokinin (CCK) and are mainly localized to the duodenum...
  56. Kozak C, Gao J, Murphy P. Mapping of the mouse macrophage inflammatory protein-1 alpha receptor gene Scya3r and two related mouse beta chemokine receptor-like genes to chromosome 9. Genomics. 1995;29:294-6 pubmed
    ..Thus, like chemokine genes and alpha chemokine receptor genes, this group of beta chemokine receptor genes arose by tandem duplication. ..
  57. Hannibal J, Hundahl C, Fahrenkrug J, Rehfeld J, Friis Hansen L. Cholecystokinin (CCK)-expressing neurons in the suprachiasmatic nucleus: innervation, light responsiveness and entrainment in CCK-deficient mice. Eur J Neurosci. 2010;32:1006-17 pubmed publisher
    ..Cholecyctokinin (CCK) is a potent neurotransmitter expressed in neurons of the mammalian SCN, but its role in circadian timing is not ..
  58. Gupta K, Copeland N, Gilbert D, Jenkins N, Gray D. Unp, a mouse gene related to the tre oncogene. Oncogene. 1993;8:2307-10 pubmed
    ..We have localized the Unp gene to mouse chromosome 9 in a region of homology with human chromosome 3p. This region has been implicated in a number of human malignancies. ..
  59. Enwright J, Wald M, Paddock M, Hoffman E, Arey R, Edwards S, et al. DeltaFosB indirectly regulates Cck promoter activity. Brain Res. 2010;1329:10-20 pubmed publisher
    ..Surprisingly, one gene that was a suspected CREB target based on previous reports, cholecystokinin (Cck), was not controlled by CREB in striatum...
  60. Hnasko T, Szczypka M, Alaynick W, During M, Palmiter R. A role for dopamine in feeding responses produced by orexigenic agents. Brain Res. 2004;1023:309-18 pubmed
    ..Since dopamine signaling in the CPu is not sufficient for glucoprivation-induced feeding, we propose that this feeding behavior may be mediated by dopamine in an anatomically distinct brain region. ..
  61. Zhu Y, Xu J, Hauswirth W, DeVries S. Genetically targeted binary labeling of retinal neurons. J Neurosci. 2014;34:7845-61 pubmed publisher
  62. Friis Hansen L. Achlorhydria is associated with gastric microbial overgrowth and development of cancer: lessons learned from the gastrin knockout mouse. Scand J Clin Lab Invest. 2006;66:607-21 pubmed
    ..Study of these mice helps our understanding of how dysregulation of gastrin secretion may be implicated in human disease. ..
  63. Jain R, Samuelson L. Transcriptional profiling of gastrin-regulated genes in mouse stomach. Physiol Genomics. 2007;29:1-12 pubmed
    ..gastrin and not hypochlorhydria were identified by comparison to mice that are deficient in both gastrin and cholecystokinin (GAS/CCK-KO), since these mice have restored basal acid secretion...
  64. Gao R, Yu Y, Inoue A, Widodo N, Kaul S, Wadhwa R. Heterogeneous nuclear ribonucleoprotein K (hnRNP-K) promotes tumor metastasis by induction of genes involved in extracellular matrix, cell movement, and angiogenesis. J Biol Chem. 2013;288:15046-56 pubmed publisher
    ..Involvement of the selected genes (Cck, Mmp-3, Ptgs2, and Ctgf) and pathways was validated by gene-specific expression analysis...
  65. Sundaresan S, Shahid R, Riehl T, Chandra R, Nassir F, Stenson W, et al. CD36-dependent signaling mediates fatty acid-induced gut release of secretin and cholecystokinin. FASEB J. 2013;27:1191-202 pubmed publisher
    ..We explored whether CD36 signaling influences FA-mediated secretion of cholecystokinin (CCK) and secretin, peptides released by enteroendocrine cells (EECs) in the duodenum/jejunum, which regulate ..
  66. Lo C, Langhans W, Georgievsky M, Arnold M, Caldwell J, Cheng S, et al. Apolipoprotein AIV requires cholecystokinin and vagal nerves to suppress food intake. Endocrinology. 2012;153:5857-65 pubmed publisher
    Apolipoprotein AIV (apo AIV) and cholecystokinin (CCK) are gastrointestinal satiation signals that are stimulated by fat consumption. Previous studies have demonstrated that peripheral apo AIV cannot cross the blood-brain barrier...
  67. CHAO C, Loomis Z, Lee J, Sussel L. Genetic identification of a novel NeuroD1 function in the early differentiation of islet alpha, PP and epsilon cells. Dev Biol. 2007;312:523-32 pubmed
    ..Furthermore, this study reveals a previously unappreciated early function of NeuroD1 in regulating the specification of alpha, PP and epsilon cells. ..
  68. Elliott R, Yen C. DNA variants with telomere probe enable genetic mapping of ends of mouse chromosomes. Mamm Genome. 1991;1:118-22 pubmed locus Xmv-9, previously mapped near the distal end of the map of chromosome (Chr) 4 and three fragments to Cck, near the distal end of Chr 9, suggesting that these fragments are telomeric and represent the ends of the ..
  69. Friedman J, Schneider B, Powell D. Differential expression of the mouse cholecystokinin gene during brain and gut development. Proc Natl Acad Sci U S A. 1985;82:5593-7 pubmed
    b>Cholecystokinin (CCK) is a neuropeptide found in brain and intestine. In this report, we have isolated a cDNA clone that encodes CCK from a mouse brain cDNA library...
  70. Lavine J, Kibbe C, Baan M, Sirinvaravong S, Umhoefer H, Engler K, et al. Cholecystokinin expression in the β-cell leads to increased β-cell area in aged mice and protects from streptozotocin-induced diabetes and apoptosis. Am J Physiol Endocrinol Metab. 2015;309:E819-28 pubmed publisher
    b>Cholecystokinin (CCK) is a peptide hormone produced in the gut and brain with beneficial effects on digestion, satiety, and insulin secretion...
  71. Miner L, Marley R. Chromosomal mapping of the psychomotor stimulant effects of cocaine in BXD recombinant inbred mice. Psychopharmacology (Berl). 1995;122:209-14 pubmed
    ..The largest associations for baseline activity were observed on chromosomes 5 and 9 and the largest associations for cocaine's psychomotor stimulant effects on chromosomes 3 and 17. ..
  72. Naylor S, Carritt B, Boileau C, Beroud C, Alexander C, Allderdice P, et al. Report of the sixth international workshop on human chromosome 3 mapping 1995. Cytogenet Cell Genet. 1996;72:255-70 pubmed
  73. Bonnavion R, Teinturier R, Jaafar R, Ripoche D, Leteurtre E, Chen Y, et al. Islet Cells Serve as Cells of Origin of Pancreatic Gastrin-Positive Endocrine Tumors. Mol Cell Biol. 2015;35:3274-83 pubmed publisher
    ..Our work provides insight into the histogenesis of pancreatic gastrin-expressing tumors. ..
  74. Zhang J, Liu S, Zhang H, Li Y, Wu W, Zhang H. Gut satiety hormones cholecystokinin and glucagon-like Peptide-17-36 amide mediate anorexia induction by trichothecenes T-2 toxin, HT-2 toxin, diacetoxyscirpenol and neosolaniol. Toxicol Appl Pharmacol. 2017;335:49-55 pubmed publisher
    ..anorectic responses, and this response has been directly linked to secretion of the gut satiety hormones cholecystokinin (CCK) and glucagon-like peptide-17-36 amide (GLP-1)...
  75. Yamane T, Suzui S, Kitaura H, Takahashi Niki K, Iguchi Ariga S, Ariga H. Transcriptional activation of the cholecystokinin gene by DJ-1 through interaction of DJ-1 with RREB1 and the effect of DJ-1 on the cholecystokinin level in mice. PLoS ONE. 2013;8:e78374 pubmed publisher
    ..In this study, we found that the cholecystokinin (CCK) gene is a transcriptional target gene for DJ-1...
  76. Worthington J, Samuelson L, Grencis R, McLaughlin J. Adaptive immunity alters distinct host feeding pathways during nematode induced inflammation, a novel mechanism in parasite expulsion. PLoS Pathog. 2013;9:e1003122 pubmed publisher
    ..Through the infection of genetically modified mice lacking cholecystokinin, Tumor necrosis factor ? receptors and T and B-cells, we observed a biphasic hypophagic response to infection ..
  77. Carney R, Mangin J, Hayes L, Mansfield K, Sousa V, Fishell G, et al. Sonic hedgehog expressing and responding cells generate neuronal diversity in the medial amygdala. Neural Dev. 2010;5:14 pubmed publisher
  78. Wyeth M, Zhang N, Houser C. Increased cholecystokinin labeling in the hippocampus of a mouse model of epilepsy maps to spines and glutamatergic terminals. Neuroscience. 2012;202:371-83 pubmed publisher
    The neuropeptide cholecystokinin (CCK) is abundant in the CNS and is expressed in a subset of inhibitory interneurons, particularly in their axon terminals...
  79. Heldt S, Ressler K. The Use of Lentiviral Vectors and Cre/loxP to Investigate the Function of Genes in Complex Behaviors. Front Mol Neurosci. 2009;2:22 pubmed publisher
    ..These conditional gene targeting strategies provide useful tools to study the endogenous mechanisms underlying complex behaviors and to model disease states resulting from aberrant gene expression. ..
  80. Gamble J, Kenny S, Dockray G. Plasminogen activator inhibitor (PAI)-1 suppresses inhibition of gastric emptying by cholecystokinin (CCK) in mice. Regul Pept. 2013;185:9-13 pubmed publisher
    The intestinal hormone cholecystokinin (CCK) delays gastric emptying and inhibits food intake by actions on vagal afferent neurons...
  81. Shekhar K, Lapan S, Whitney I, Tran N, Macosko E, Kowalczyk M, et al. Comprehensive Classification of Retinal Bipolar Neurons by Single-Cell Transcriptomics. Cell. 2016;166:1308-1323.e30 pubmed publisher
    ..This work provides a systematic methodology for achieving comprehensive molecular classification of neurons, identifies novel neuronal types, and uncovers transcriptional differences that distinguish types within a class. ..
  82. Zhou H, Pestka J. Deoxynivalenol (Vomitoxin)-Induced Cholecystokinin and Glucagon-Like Peptide-1 Release in the STC-1 Enteroendocrine Cell Model Is Mediated by Calcium-Sensing Receptor and Transient Receptor Potential Ankyrin-1 Channel. Toxicol Sci. 2015;145:407-17 pubmed publisher
    ..The results indicate for the first time that DON elicits Ca(2)-dependent secretion of cholecystokinin (CCK) and glucagon-like peptide-1(7-36) amide (GLP-1), hormones that regulate food intake and energy ..
  83. del Pino I, Brotons Mas J, Marques Smith A, Marighetto A, Frick A, Marin O, et al. Abnormal wiring of CCK+ basket cells disrupts spatial information coding. Nat Neurosci. 2017;20:784-792 pubmed publisher
    ..This is particularly true for a major population of basket cells that express the neuropeptide cholecystokinin (CCK)...
  84. Gil V, Bichler Z, Lee J, Seira O, Llorens F, Bribian A, et al. Developmental expression of the oligodendrocyte myelin glycoprotein in the mouse telencephalon. Cereb Cortex. 2010;20:1769-79 pubmed publisher
    ..Our data support the idea that early expressed MAIPs play an active role during development and point to OMgp participating in thalamo-cortical connections. ..
  85. Rasoamanana R, Chaumontet C, Nadkarni N, Tome D, Fromentin G, Darcel N. Dietary fibers solubilized in water or an oil emulsion induce satiation through CCK-mediated vagal signaling in mice. J Nutr. 2012;142:2033-9 pubmed publisher
    ..blockade of gut peptide receptors showed that these effects were dependent on the peripheral signaling of cholecystokinin but not of glucagon-like peptide 1, suggesting that anorectic signals emerge from the upper intestine rather ..
  86. Li K, Christiano A, Copeland N, Gilbert D, Chu M, Jenkins N, et al. cDNA cloning and chromosomal mapping of the mouse type VII collagen gene (Col7a1): evidence for rapid evolutionary divergence of the gene. Genomics. 1993;16:733-9 pubmed
    ..This assignment confirms and extends the relationship between the mouse and the human chromosomes in this region of the genome. ..
  87. Aunapuu M, Roosaar P, Järveots T, Kurrikoff K, Koks S, Vasar E, et al. Altered renal morphology in transgenic mice with cholecystokinin overexpression. Transgenic Res. 2008;17:1079-89 pubmed publisher
    Although cholecystokinin is a regulatory peptide with a predominant role in the brain and the gastrointestinal tract, there is an increasing evidence for its role in the kidney...
  88. Nagata A, Ito M, Iwata N, Kuno J, Takano H, Minowa O, et al. G protein-coupled cholecystokinin-B/gastrin receptors are responsible for physiological cell growth of the stomach mucosa in vivo. Proc Natl Acad Sci U S A. 1996;93:11825-30 pubmed
    ..Here we have generated G protein-coupled cholecystokinin (CCK)-B/gastrin receptor deficient-mice by gene targeting...
  89. Ingram M, Wozniak E, Duvick L, Yang R, Bergmann P, Carson R, et al. Cerebellar Transcriptome Profiles of ATXN1 Transgenic Mice Reveal SCA1 Disease Progression and Protection Pathways. Neuron. 2016;89:1194-1207 pubmed publisher
    ..Furthermore, we found that upregulation of cholecystokinin (Cck) and subsequent interaction with the Cck1 receptor likely underlies the lack of progressive Purkinje ..
  90. Garfield A, Shah B, Madara J, Burke L, Patterson C, Flak J, et al. A parabrachial-hypothalamic cholecystokinin neurocircuit controls counterregulatory responses to hypoglycemia. Cell Metab. 2014;20:1030-7 pubmed publisher
    ..Here we demonstrate that lateral parabrachial nucleus cholecystokinin (CCK(LPBN)) neurons are a population of glucose-sensing cells (glucose inhibited) with counterregulatory ..