Gene Symbol: Ccdc88a
Description: coiled coil domain containing 88A
Alias: A430106J12Rik, AI848406, Ape, C130096N06Rik, C330012F17Rik, D130005J21Rik, Girdin, Giv, Grdn, Hkrp1, girdin, Akt-phosphorylation enhancer, Hook-related protein 1, coiled-coil domain-containing protein 88A, g alpha-interacting vesicle-associated protein, girders of actin filament
Species: mouse
Products:     Ccdc88a

Top Publications

  1. Simpson F, Martin S, Evans T, Kerr M, James D, Parton R, et al. A novel hook-related protein family and the characterization of hook-related protein 1. Traffic. 2005;6:442-58 pubmed
    ..This domain has been shown to bind microtubules in the Hook protein and show that the HkRP1 protein is microtubule-associated...
  2. Kitamura T, Asai N, Enomoto A, Maeda K, Kato T, Ishida M, et al. Regulation of VEGF-mediated angiogenesis by the Akt/PKB substrate Girdin. Nat Cell Biol. 2008;10:329-37 pubmed publisher
    ..Here we report that Akt-mediated phosphorylation of Girdin, an actin-binding protein, promotes VEGF-dependent migration of endothelial cells and tube formation by these ..
  3. Jiang P, Enomoto A, Jijiwa M, Kato T, Hasegawa T, Ishida M, et al. An actin-binding protein Girdin regulates the motility of breast cancer cells. Cancer Res. 2008;68:1310-8 pubmed publisher
    b>Girdin (girders of actin filaments) is a novel actin-binding Akt substrate that plays an important role in actin organization and Akt-dependent cell motility in fibroblasts...
  4. Garcia Marcos M, Ghosh P, Ear J, Farquhar M. A structural determinant that renders G alpha(i) sensitive to activation by GIV/girdin is required to promote cell migration. J Biol Chem. 2010;285:12765-77 pubmed publisher
    ..Here we investigated the structural determinants in G alpha(i3) necessary for its regulation by GIV/girdin, a guanine-nucleotide exchange factor (GEF) that activates G alpha(i) subunits...
  5. Anai M, Shojima N, Katagiri H, Ogihara T, Sakoda H, Onishi Y, et al. A novel protein kinase B (PKB)/AKT-binding protein enhances PKB kinase activity and regulates DNA synthesis. J Biol Chem. 2005;280:18525-35 pubmed
    ..Thus, we termed this Akt-specific binding protein APE (Akt-phosphorylation enhancer)...
  6. Le Niculescu H, Niesman I, Fischer T, DeVries L, Farquhar M. Identification and characterization of GIV, a novel Galpha i/s-interacting protein found on COPI, endoplasmic reticulum-Golgi transport vesicles. J Biol Chem. 2005;280:22012-20 pubmed
    In this report, we characterize GIV (Galpha-interacting vesicle-associated protein), a novel protein that binds members of the Galpha(i) and Galpha subfamilies of heterotrimeric G proteins...
  7. Ohara K, Enomoto A, Kato T, Hashimoto T, Isotani Sakakibara M, Asai N, et al. Involvement of Girdin in the determination of cell polarity during cell migration. PLoS ONE. 2012;7:e36681 pubmed publisher
    ..b>Girdin (girders of actin filaments) (also termed GIV, G?-interacting vesicle associated protein) is an actin-binding ..
  8. Kim J, Duan X, Liu C, Jang M, Guo J, Pow Anpongkul N, et al. DISC1 regulates new neuron development in the adult brain via modulation of AKT-mTOR signaling through KIAA1212. Neuron. 2009;63:761-73 pubmed publisher
  9. Enomoto A, Asai N, Namba T, Wang Y, Kato T, Tanaka M, et al. Roles of disrupted-in-schizophrenia 1-interacting protein girdin in postnatal development of the dentate gyrus. Neuron. 2009;63:774-87 pubmed publisher
    ..Here, we report that DISC1 interacts with the actin-binding protein girdin to regulate axonal development...

More Information


  1. Miyake H, Maeda K, Asai N, Shibata R, Ichimiya H, Isotani Sakakibara M, et al. The actin-binding protein Girdin and its Akt-mediated phosphorylation regulate neointima formation after vascular injury. Circ Res. 2011;108:1170-9 pubmed publisher
    ..Our previous study showed that the Akt substrate Girdin, which is expressed in VSMCs and endothelial cells, is essential for postnatal angiogenesis...
  2. Wang Y, Kaneko N, Asai N, Enomoto A, Isotani Sakakibara M, Kato T, et al. Girdin is an intrinsic regulator of neuroblast chain migration in the rostral migratory stream of the postnatal brain. J Neurosci. 2011;31:8109-22 pubmed publisher
    ..Here we show that mice lacking the actin-binding Akt substrate Girdin (a protein that interacts with Disrupted-In-Schizophrenia 1 to regulate neurogenesis in the dentate gyrus) have ..
  3. Wu D, Yu D, Wang X, Yu B. F-actin rearrangement is regulated by mTORC2/Akt/Girdin in mouse fertilized eggs. Cell Prolif. 2016;49:740-750 pubmed publisher
    ..In this study, mTORC2, PKB/Akt and Girdin were found to modulate division of mouse fertilized eggs by regulating distribution of the actin cytoskeleton...
  4. Hayano S, Takefuji M, Maeda K, Noda T, Ichimiya H, Kobayashi K, et al. Akt-dependent Girdin phosphorylation regulates repair processes after acute myocardial infarction. J Mol Cell Cardiol. 2015;88:55-63 pubmed publisher
    ..We previously reported that Akt-mediated Girdin phosphorylation is essential for angiogenesis and neointima formation...
  5. Ota H, Hikita T, Nishioka T, Matsumoto M, Ito J, Asai N, et al. Proteomic analysis of Girdin-interacting proteins in migrating new neurons in the postnatal mouse brain. Biochem Biophys Res Commun. 2013;442:16-21 pubmed publisher
    ..that control postnatal neuronal migration, we performed a global proteomic search for proteins interacting with Girdin, an essential protein for postnatal neuronal migration...
  6. López Sánchez I, Dunkel Y, Roh Y, Mittal Y, De Minicis S, Murányi A, et al. GIV/Girdin is a central hub for profibrogenic signalling networks during liver fibrosis. Nat Commun. 2014;5:4451 pubmed publisher
    ..Here we report the discovery of a signalling platform comprising G protein subunit, G?i and GIV, its guanine exchange factor (GEF), which serves as a central hub within the fibrogenic signalling network ..
  7. Muramatsu A, Enomoto A, Kato T, Weng L, Kuroda K, Asai N, et al. Potential involvement of kinesin-1 in the regulation of subcellular localization of Girdin. Biochem Biophys Res Commun. 2015;463:999-1005 pubmed publisher
    b>Girdin is an actin-binding protein that has multiple functions in postnatal neural development and cancer progression...
  8. Yamamura Y, Asai N, Enomoto A, Kato T, Mii S, Kondo Y, et al. Akt-Girdin signaling in cancer-associated fibroblasts contributes to tumor progression. Cancer Res. 2015;75:813-23 pubmed publisher
    ..Here, we report that the Akt substrate Girdin, an actin-binding protein that regulates cell migration, is expressed and activated by Akt phosphorylation in ..
  9. Siletti K, Tarchini B, Hudspeth A. Daple coordinates organ-wide and cell-intrinsic polarity to pattern inner-ear hair bundles. Proc Natl Acad Sci U S A. 2017;114:E11170-E11179 pubmed publisher
    ..Our results suggest that the primary cilium or an associated structure influences the domain of cell-intrinsic signals that shape the hair bundle. Daple is therefore essential to orient and pattern sensory hair bundles. ..
  10. Kuga D, Ushida K, Mii S, Enomoto A, Asai N, Nagino M, et al. Tyrosine Phosphorylation of an Actin-Binding Protein Girdin Specifically Marks Tuft Cells in Human and Mouse Gut. J Histochem Cytochem. 2017;65:347-366 pubmed publisher
    ..We developed site-specific and phosphorylation-status-specific antibodies against Girdin at tyrosine-1798 (pY1798) and found pY1798 immunostaining of mouse jejunum clearly depicted epithelial cells ..
  11. Leyme A, Marivin A, Perez Gutierrez L, Nguyen L, Garcia Marcos M. Integrins activate trimeric G proteins via the nonreceptor protein GIV/Girdin. J Cell Biol. 2015;210:1165-84 pubmed publisher
    ..of the trimeric G protein Gαi by the nonreceptor guanine nucleotide exchange factor (GEF) GIV (also known as Girdin), a metastasis-associated protein...
  12. Nakai T, Nagai T, Tanaka M, Itoh N, Asai N, Enomoto A, et al. Girdin phosphorylation is crucial for synaptic plasticity and memory: a potential role in the interaction of BDNF/TrkB/Akt signaling with NMDA receptor. J Neurosci. 2014;34:14995-5008 pubmed publisher
    ..b>Girdin (also known as APE, GIV, and HkRP1), an actin-binding protein involved both in the remodeling of the actin ..
  13. Weng L, Enomoto A, Miyoshi H, Takahashi K, Asai N, Morone N, et al. Regulation of cargo-selective endocytosis by dynamin 2 GTPase-activating protein girdin. EMBO J. 2014;33:2098-112 pubmed publisher
    ..Here, we show that the actin-binding protein girdin is a regulator of cargo-selective CME...
  14. Asai M, Asai N, Murata A, Yokota H, Ohmori K, Mii S, et al. Similar phenotypes of Girdin germ-line and conditional knockout mice indicate a crucial role for Girdin in the nestin lineage. Biochem Biophys Res Commun. 2012;426:533-8 pubmed publisher
    b>Girdin is an Akt substrate and actin-binding protein...
  15. Omori K, Asai M, Kuga D, Ushida K, Izuchi T, Mii S, et al. Girdin is phosphorylated on tyrosine 1798 when associated with structures required for migration. Biochem Biophys Res Commun. 2015;458:934-40 pubmed publisher
    The mammalian protein Girdin interacts with several key molecules such as actin, and it functions as a regulator of the cytoskeleton. Silencing of Girdin mRNA results in defective migration in a variety of cultured cells...
  16. Hartung A, Ordelheide A, Staiger H, Melzer M, Haring H, Lammers R. The Akt substrate Girdin is a regulator of insulin signaling in myoblast cells. Biochim Biophys Acta. 2013;1833:2803-2811 pubmed publisher
    ..Recently, Girdin has been described as an Akt substrate that is expressed ubiquitously in mammals...
  17. Ito T, Komeima K, Yasuma T, Enomoto A, Asai N, Asai M, et al. Girdin and its phosphorylation dynamically regulate neonatal vascular development and pathological neovascularization in the retina. Am J Pathol. 2013;182:586-96 pubmed publisher
    ..The Akt substrate girdin, an actin-binding protein, is known to regulate VEGF-mediated postnatal angiogenesis...
  18. Nahorski M, Asai M, Wakeling E, Parker A, Asai N, Canham N, et al. CCDC88A mutations cause PEHO-like syndrome in humans and mouse. Brain. 2016;139:1036-44 pubmed publisher
    ..consanguineous family with the PEHO phenotype where affected individuals had a homozygous frame-shift deletion in CCDC88A (c.2313delT, p.Leu772*ter)...