Cbx5

Summary

Gene Symbol: Cbx5
Description: chromobox 5
Alias: 2610029O15Rik, C75991, HP1, Hp1a, Hp1alpha, chromobox protein homolog 5, HP1 alpha, chromobox homolog 5, heterochromatin protein 1 alpha, heterochromatin protein 1 homolog alpha, mHP1(alpha)
Species: mouse
Products:     Cbx5

Top Publications

  1. Seki Y, Hayashi K, Itoh K, Mizugaki M, Saitou M, Matsui Y. Extensive and orderly reprogramming of genome-wide chromatin modifications associated with specification and early development of germ cells in mice. Dev Biol. 2005;278:440-58 pubmed
  2. Li Y, Pak B, Higgins R, Lu S, Ben David Y. Contiguous arrangement of p45 NFE2, HnRNP A1, and HP1 alpha on mouse chromosome 15 and human chromosome 12: evidence for suppression of these genes due to retroviral integration within the Fli-2 locus. Genes Chromosomes Cancer. 2001;30:91-5 pubmed
    ..Here, we report the identification of a third gene, Heterochromatin protein 1 (HP1alpha, also known as CBX5), which is located downstream of HnRNP A1, and p45 NFE2...
  3. Zhang P, Du J, Sun B, Dong X, Xu G, Zhou J, et al. Structure of human MRG15 chromo domain and its binding to Lys36-methylated histone H3. Nucleic Acids Res. 2006;34:6621-8 pubmed
    ..a long alpha-helix and assumes a structure more similar to the Drosophila MOF chromo barrel domain than the typical HP1/Pc chromo domains...
  4. Villeneuve L, Reddy M, Lanting L, Wang M, Meng L, Natarajan R. Epigenetic histone H3 lysine 9 methylation in metabolic memory and inflammatory phenotype of vascular smooth muscle cells in diabetes. Proc Natl Acad Sci U S A. 2008;105:9047-52 pubmed publisher
    ..Recruitment of corepressor HP1alpha was also reduced under these conditions in db/db cells...
  5. Dong K, Maksakova I, Mohn F, Leung D, Appanah R, Lee S, et al. DNA methylation in ES cells requires the lysine methyltransferase G9a but not its catalytic activity. EMBO J. 2008;27:2691-701 pubmed publisher
    ..silent in G9a(-/-) cells, and show only a modest decrease in H3K9me2 and no decrease in H3K9me3 or HP1alpha binding, indicating that H3K9 methylation per se is not the relevant trigger for DNA methylation...
  6. Maison C, Bailly D, Roche D, Montes De Oca R, Probst A, Vassias I, et al. SUMOylation promotes de novo targeting of HP1? to pericentric heterochromatin. Nat Genet. 2011;43:220-7 pubmed publisher
    b>HP1 enrichment at pericentric heterochromatin is considered important for centromere function...
  7. Nielsen A, Ortiz J, You J, Oulad Abdelghani M, Khechumian R, Gansmuller A, et al. Interaction with members of the heterochromatin protein 1 (HP1) family and histone deacetylation are differentially involved in transcriptional silencing by members of the TIF1 family. EMBO J. 1999;18:6385-95 pubmed
    ..shows that endogenous TIF1beta, but not TIF1alpha, is associated with members of the heterochromatin protein 1 (HP1) family. However, in vitro, both TIF1alpha and TIF1beta interact with and phosphorylate the HP1 proteins...
  8. Herzog M, Wendling O, Guillou F, Chambon P, Mark M, Losson R, et al. TIF1? association with HP1 is essential for post-gastrulation development, but not for Sertoli cell functions during spermatogenesis. Dev Biol. 2011;350:548-58 pubmed publisher
    TIF1? is an essential mammalian transcriptional corepressor. It interacts with the heterochromatin proteins HP1 through a highly conserved motif, the HP1box, and we have previously shown that this interaction is essential for the ..
  9. Cammas F, Janoshazi A, Lerouge T, Losson R. Dynamic and selective interactions of the transcriptional corepressor TIF1 beta with the heterochromatin protein HP1 isotypes during cell differentiation. Differentiation. 2007;75:627-37 pubmed
    ..In mammals, there are three HP1 isotypes, HP1alpha, beta, and gamma, that appear to be involved in both eu- and heterochromatin, but whose individual functions are ..

More Information

Publications74

  1. Quivy J, Roche D, Kirschner D, Tagami H, Nakatani Y, Almouzni G. A CAF-1 dependent pool of HP1 during heterochromatin duplication. EMBO J. 2004;23:3516-26 pubmed
    ..how the complex organization of heterochromatin is reproduced at each replication cycle, we examined the fate of HP1-rich pericentric domains in mouse cells...
  2. Yamamoto K, Sonoda M. Self-interaction of heterochromatin protein 1 is required for direct binding to histone methyltransferase, SUV39H1. Biochem Biophys Res Commun. 2003;301:287-92 pubmed
    ..A yeast two-hybrid and a glutathione S-transferase pull-down study indicated that the chromo shadow domain of mHP1 alpha directly interacts with the N-terminal 39 amino acid stretch of SUV39H1...
  3. Le Douarin B, Nielsen A, Garnier J, Ichinose H, Jeanmougin F, Losson R, et al. A possible involvement of TIF1 alpha and TIF1 beta in the epigenetic control of transcription by nuclear receptors. EMBO J. 1996;15:6701-15 pubmed
    ..Using a two-hybrid screening in yeast, we have now identified two TIF1-binding proteins, mHP1 alpha and mMOD1, that are mouse homologues of the Drosophila heterochromatinic protein 1...
  4. Brasher S, Smith B, Fogh R, Nietlispach D, Thiru A, Nielsen P, et al. The structure of mouse HP1 suggests a unique mode of single peptide recognition by the shadow chromo domain dimer. EMBO J. 2000;19:1587-97 pubmed
    The heterochromatin protein 1 (HP1) family of proteins is involved in gene silencing via the formation of heterochromatic structures...
  5. Lachner M, O Carroll D, Rea S, Mechtler K, Jenuwein T. Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins. Nature. 2001;410:116-20 pubmed
    ..methyltransferases that selectively methylate histone H3 on lysine 9 (Suv39h HMTases) generate a binding site for HP1 proteins--a family of heterochromatic adaptor molecules implicated in both gene silencing and supra-nucleosomal ..
  6. Cammas F, Herzog M, Lerouge T, Chambon P, Losson R. Association of the transcriptional corepressor TIF1beta with heterochromatin protein 1 (HP1): an essential role for progression through differentiation. Genes Dev. 2004;18:2147-60 pubmed
    ..with chromatin remodeling and histone-modifying activities and recruitment of heterochromatin protein 1 (HP1) proteins...
  7. Scholzen T, Endl E, Wohlenberg C, van der Sar S, Cowell I, Gerdes J, et al. The Ki-67 protein interacts with members of the heterochromatin protein 1 (HP1) family: a potential role in the regulation of higher-order chromatin structure. J Pathol. 2002;196:135-44 pubmed
    ..domain of pKi-67 (Kon21) is able to bind to all three members of the mammalian heterochromatin protein 1 (HP1) family in vitro and in vivo...
  8. Muchardt C, Guilleme M, Seeler J, Trouche D, Dejean A, Yaniv M. Coordinated methyl and RNA binding is required for heterochromatin localization of mammalian HP1alpha. EMBO Rep. 2002;3:975-81 pubmed
    ..We show that the association of HP1alpha with pericentromeric heterochromatin depends not only on its methyl-binding chromo domain but also on an RNA-..
  9. Thiru A, Nietlispach D, Mott H, Okuwaki M, Lyon D, Nielsen P, et al. Structural basis of HP1/PXVXL motif peptide interactions and HP1 localisation to heterochromatin. EMBO J. 2004;23:489-99 pubmed
    b>HP1 family proteins are adaptor molecules, containing two related chromo domains that are required for chromatin packaging and gene silencing...
  10. Wreggett K, Hill F, James P, Hutchings A, Butcher G, Singh P. A mammalian homologue of Drosophila heterochromatin protein 1 (HP1) is a component of constitutive heterochromatin. Cytogenet Cell Genet. 1994;66:99-103 pubmed
    The Drosophila HP1 gene contains a highly conserved sequence, the chromobox, which can be used to isolate HP1-like genes from both mouse (M31 and M32) and man (HSM1) (Singh et al., 1991)...
  11. Cammas F, Oulad Abdelghani M, Vonesch J, Huss Garcia Y, Chambon P, Losson R. Cell differentiation induces TIF1beta association with centromeric heterochromatin via an HP1 interaction. J Cell Sci. 2002;115:3439-48 pubmed
    ..in the PxVxL motif of TIF1beta, which abolish interaction with members of the heterochromatin protein 1 (HP1) family, prevent its centromeric localization in differentiated cells...
  12. Agarwal N, Hardt T, Brero A, Nowak D, Rothbauer U, Becker A, et al. MeCP2 interacts with HP1 and modulates its heterochromatin association during myogenic differentiation. Nucleic Acids Res. 2007;35:5402-8 pubmed
    ..evidence of crosstalk between epigenetic modifications such as histone and DNA methylation, recognized by HP1 and methyl CpG-binding proteins, respectively...
  13. Yamamoto K, Sonoda M, Inokuchi J, Shirasawa S, Sasazuki T. Polycomb group suppressor of zeste 12 links heterochromatin protein 1alpha and enhancer of zeste 2. J Biol Chem. 2004;279:401-6 pubmed
    ..We now report that the mammalian SU(Z)12 directly interacts with heterochromatin protein 1alpha (HP1alpha) and PcG enhancer of zeste 2 (EZH2), the mammalian counterpart of E(z), in vitro and in vivo...
  14. Wolf D, Cammas F, Losson R, Goff S. Primer binding site-dependent restriction of murine leukemia virus requires HP1 binding by TRIM28. J Virol. 2008;82:4675-9 pubmed publisher
    ..silencing of the integrated provirus and has been shown to correlate with TRIM28-mediated recruitment of HP1 to the silenced loci...
  15. Daujat S, Zeissler U, Waldmann T, Happel N, Schneider R. HP1 binds specifically to Lys26-methylated histone H1.4, whereas simultaneous Ser27 phosphorylation blocks HP1 binding. J Biol Chem. 2005;280:38090-5 pubmed
    ..Hetero-chromatin protein 1 (HP1), an essential component of heterochromatin, binds specifically to methylated Lys(9) of histone H3 (K9/H3)...
  16. Sridharan R, Gonzales Cope M, Chronis C, Bonora G, McKee R, Huang C, et al. Proteomic and genomic approaches reveal critical functions of H3K9 methylation and heterochromatin protein-1? in reprogramming to pluripotency. Nat Cell Biol. 2013;15:872-82 pubmed publisher
    ..Together, our findings demonstrate that Cbx3 and H3K9 methylation restrict late reprogramming events, and suggest that a marked change in global chromatin character constitutes an epigenetic roadblock for reprogramming. ..
  17. Susperreguy S, Prendes L, Desbats M, Charó N, Brown K, MacDougald O, et al. Visualization by BiFC of different C/EBP? dimers and their interaction with HP1? reveals a differential subnuclear distribution of complexes in living cells. Exp Cell Res. 2011;317:706-23 pubmed publisher
    ..Importantly, their differential subnuclear distribution mirrors the site for interaction with HP1?...
  18. Zhang C, McKinsey T, Olson E. Association of class II histone deacetylases with heterochromatin protein 1: potential role for histone methylation in control of muscle differentiation. Mol Cell Biol. 2002;22:7302-12 pubmed
    ..Here we report that MITR, HDAC4, and HDAC5 associate with heterochromatin protein 1 (HP1), an adaptor protein that recognizes methylated lysines within histone tails and mediates transcriptional ..
  19. Hansen R, Mund A, Poulsen S, Sandoval M, Klement K, Tsouroula K, et al. SCAI promotes DNA double-strand break repair in distinct chromosomal contexts. Nat Cell Biol. 2016;18:1357-1366 pubmed publisher
    ..Collectively, our findings uncover SCAI as a physiologically important component of both NHEJ- and HR-mediated pathways that potentiates DSB repair efficiency in specific chromatin contexts. ..
  20. Polioudaki H, Kourmouli N, Drosou V, Bakou A, Theodoropoulos P, Singh P, et al. Histones H3/H4 form a tight complex with the inner nuclear membrane protein LBR and heterochromatin protein 1. EMBO Rep. 2001;2:920-5 pubmed
    We have recently shown that heterochromatin protein 1 (HP1) interacts with the nuclear envelope in an acetylation-dependent manner...
  21. Craig J, Earle E, Canham P, Wong L, Anderson M, Choo K. Analysis of mammalian proteins involved in chromatin modification reveals new metaphase centromeric proteins and distinct chromosomal distribution patterns. Hum Mol Genet. 2003;12:3109-21 pubmed
    ..and other major heterochromatic regions; and (b) heterochromatin-associated proteins (MeCP2, MBD1, MBD2, ATRX, HP1alpha, HDAC1, HDAC2, DNMT1 and DNMT3b), which colocalize with centromeric/pericentric heterochromatin and all other ..
  22. Jeevan Raj B, Robert I, Heyer V, Page A, Wang J, Cammas F, et al. Epigenetic tethering of AID to the donor switch region during immunoglobulin class switch recombination. J Exp Med. 2011;208:1649-60 pubmed publisher
    ..In this study, we show that during CSR, AID forms a complex with KAP1 (KRAB domain-associated protein 1) and HP1 (heterochromatin protein 1) that is tethered to the donor switch region (S?) bearing H3K9me3 (trimethylated histone ..
  23. Kourmouli N, Theodoropoulos P, Dialynas G, Bakou A, Politou A, Cowell I, et al. Dynamic associations of heterochromatin protein 1 with the nuclear envelope. EMBO J. 2000;19:6558-68 pubmed
    To study the dynamics of mammalian HP1 proteins we have microinjected recombinant forms of mHP1alpha, M31 and M32 into the cytoplasm of living cells...
  24. Hiragami Hamada K, Shinmyozu K, Hamada D, Tatsu Y, Uegaki K, Fujiwara S, et al. N-terminal phosphorylation of HP1{alpha} promotes its chromatin binding. Mol Cell Biol. 2011;31:1186-200 pubmed publisher
    The phosphorylation of heterochromatin protein 1 (HP1) has been previously described in studies of mammals, but the biological implications of this modification remain largely elusive...
  25. Wongtawan T, Taylor J, Lawson K, Wilmut I, Pennings S. Histone H4K20me3 and HP1? are late heterochromatin markers in development, but present in undifferentiated embryonic stem cells. J Cell Sci. 2011;124:1878-90 pubmed publisher
    ..state that lacks the constitutive heterochromatin markers histone H4 trimethyl Lys20 (H4K20me3) and chromobox homolog 5 (HP1?, also known as CBX5)...
  26. Masse J, Laurent A, Nicol B, Guerrier D, Pellerin I, Deschamps S. Involvement of ZFPIP/Zfp462 in chromatin integrity and survival of P19 pluripotent cells. Exp Cell Res. 2010;316:1190-201 pubmed publisher
    ..P19 cells exhibited a complete destructuration of pericentromeric domains associated with a redistribution of the HP1alpha proteins and an increase in DNA satellites transcribed RNAs level...
  27. Brown J, Bullwinkel J, Baron Luhr B, Billur M, Schneider P, Winking H, et al. HP1gamma function is required for male germ cell survival and spermatogenesis. Epigenetics Chromatin. 2010;3:9 pubmed publisher
    ..In mammals, there are three genes that encode HP1-like proteins, termed HP1alpha, HP1beta and HP1gamma, which have a high degree of homology This paper describes for the first time, to our ..
  28. Koch B, Kueng S, Ruckenbauer C, Wendt K, Peters J. The Suv39h-HP1 histone methylation pathway is dispensable for enrichment and protection of cohesin at centromeres in mammalian cells. Chromosoma. 2008;117:199-210 pubmed
    ..In fission yeast, the recruitment of heterochromatin protein Swi6/HP1 to centromeres by the histone-methyltransferase Clr4/Suv39h is required for enrichment of cohesin at centromeres ..
  29. Remboutsika E, Lutz Y, Gansmuller A, Vonesch J, Losson R, Chambon P. The putative nuclear receptor mediator TIF1alpha is tightly associated with euchromatin. J Cell Sci. 1999;112 ( Pt 11):1671-83 pubmed
    ..Immunoelectron microscopy shows that, in contrast to the heterochromatin protein HP1alpha, most of TIF1alpha is associated with euchromatin, where it is preferentially localised on regions known to be ..
  30. Chan K, Zhang H, Malureanu L, van Deursen J, Zhang Z. Diverse factors are involved in maintaining X chromosome inactivation. Proc Natl Acad Sci U S A. 2011;108:16699-704 pubmed publisher
    ..describe the mechanistic roles of two proteins--origin recognition complex 2 (Orc2) and heterochromatin protein 1 (HP1?)--in Xi silencing. Immunofluorescence studies indicate that Orc2 and HP1? localize on Xi in mouse cells...
  31. de la Cruz C, Kirmizis A, Simon M, Isono K, Koseki H, Panning B. The polycomb group protein SUZ12 regulates histone H3 lysine 9 methylation and HP1 alpha distribution. Chromosome Res. 2007;15:299-314 pubmed
    ..Knockdown of SUZ12 in human cells caused a reduction in H3K27me3 and H3K9me3, and altered the distribution of HP1 alpha. In contrast, EZH2 knockdown caused loss of H3K27me3 but not H3K9me3, indicating that SUZ12 regulates H3-K9 ..
  32. Whelan G, Kreidl E, Wutz G, Egner A, Peters J, Eichele G. Cohesin acetyltransferase Esco2 is a cell viability factor and is required for cohesion in pericentric heterochromatin. EMBO J. 2012;31:71-82 pubmed publisher
    ..Our results suggest that Esco2 is needed for cohesin acetylation in PCH and that this modification is required for the proper distribution of cohesin on mitotic chromosomes and for centromeric cohesion. ..
  33. Mateos Langerak J, Brink M, Luijsterburg M, van der Kraan I, van Driel R, Verschure P. Pericentromeric heterochromatin domains are maintained without accumulation of HP1. Mol Biol Cell. 2007;18:1464-71 pubmed
    ..of HP1 in maintaining heterochromatin structure, we used a dominant negative approach by expressing truncated HP1alpha or HP1beta proteins lacking a functional chromodomain...
  34. Maison C, Romeo K, Bailly D, Dubarry M, Quivy J, Almouzni G. The SUMO protease SENP7 is a critical component to ensure HP1 enrichment at pericentric heterochromatin. Nat Struct Mol Biol. 2012;19:458-60 pubmed publisher
    SUMOylation promotes targeting of HP1? to pericentric heterochromatin. Here we identify the SUMO-specific protease SENP7 in mouse as a maintenance factor for HP1? accumulation at this location...
  35. Westendorp B, Major J, Nader M, Salih M, Leenen F, Tuana B. The E2F6 repressor activates gene expression in myocardium resulting in dilated cardiomyopathy. FASEB J. 2012;26:2569-79 pubmed publisher
    ..The data highlight an unprecedented role for the strict regulation of the E2F pathway in normal postnatal cardiac function. ..
  36. Auth T, Kunkel E, Grummt F. Interaction between HP1alpha and replication proteins in mammalian cells. Exp Cell Res. 2006;312:3349-59 pubmed
    ..Using the yeast two-hybrid system and immunoprecipitation, we report here that murine HP1alpha interacts with the preRC proteins ORC1, ORC2 and CDC6...
  37. Miyagi S, Koide S, Saraya A, Wendt G, Oshima M, Konuma T, et al. The TIF1?-HP1 system maintains transcriptional integrity of hematopoietic stem cells. Stem Cell Reports. 2014;2:145-52 pubmed publisher
    ..Levels of heterochromatin protein 1 (HP1?, ? and ?) proteins, which form a complex with TIF1?, were significantly reduced in the absence of TIF1? and ..
  38. Khetchoumian K, Teletin M, Mark M, Lerouge T, Cerviño M, Oulad Abdelghani M, et al. TIF1delta, a novel HP1-interacting member of the transcriptional intermediary factor 1 (TIF1) family expressed by elongating spermatids. J Biol Chem. 2004;279:48329-41 pubmed
    ..like TIF1alpha and TIF1beta, TIF1delta can homodimerize and contains a PXVXL motif necessary and sufficient for HP1 (heterochromatin protein 1) binding...
  39. Legartova S, Jugova A, Stixova L, Kozubek S, Fojtova M, Zdrahal Z, et al. Epigenetic aspects of HP1 exchange kinetics in apoptotic chromatin. Biochimie. 2013;95:167-79 pubmed publisher
    ..and histone deacetylation in apoptotic bodies was likely responsible for the pronounced (?40%) recovery of GFP-HP1? and GFP-HP1? after photobleaching...
  40. Hinde E, Cardarelli F, Gratton E. Spatiotemporal regulation of Heterochromatin Protein 1-alpha oligomerization and dynamics in live cells. Sci Rep. 2015;5:12001 pubmed publisher
    Heterochromatin protein 1 (HP1) is a central factor in establishing and maintaining the heterochromatin state...
  41. Toh K, Ramdas N, Shivashankar G. Actin cytoskeleton differentially alters the dynamics of lamin A, HP1α and H2B core histone proteins to remodel chromatin condensation state in living cells. Integr Biol (Camb). 2015;7:1309-17 pubmed publisher
    ..assays, we also demonstrate an actin-driven differential modulation of core histone H2B and heterochromatin HP1α protein dynamics with chromatin...
  42. Asano Y, Takashima S, Asakura M, Shintani Y, Liao Y, Minamino T, et al. Lamr1 functional retroposon causes right ventricular dysplasia in mice. Nat Genet. 2004;36:123-30 pubmed
    ..We found that heterochromatin protein 1 (HP1) bound specifically to mutant LAMR1...
  43. Alonso M, Zoidl G, Taveggia C, Bosse F, Zoidl C, Rahman M, et al. Identification and characterization of ZFP-57, a novel zinc finger transcription factor in the mammalian peripheral nervous system. J Biol Chem. 2004;279:25653-64 pubmed
    ..Zfp-57 mRNA is up-regulated in Schwann cells in response to leukemia inhibitory factor and fibroblast growth factor 2...
  44. Brancorsini S, Davidson I, Sassone Corsi P. TIPT, a male germ cell-specific partner of TRF2, is chromatin-associated and interacts with HP1. Cell Cycle. 2008;7:1415-22 pubmed
    ..Importantly, TIPT interacts also with HP1 proteins, thereby establishing an intriguing link between transcription and chromatin condensation...
  45. Meglicki M, Zientarski M, Borsuk E. Constitutive heterochromatin during mouse oogenesis: the pattern of histone H3 modifications and localization of HP1alpha and HP1beta proteins. Mol Reprod Dev. 2008;75:414-28 pubmed
    ..In somatic cells, the HP1alpha and HP1beta proteins are indispensable for constitutive heterochromatin formation and maintenance...
  46. Dannenberg J, David G, Zhong S, van der Torre J, Wong W, Depinho R. mSin3A corepressor regulates diverse transcriptional networks governing normal and neoplastic growth and survival. Genes Dev. 2005;19:1581-95 pubmed
  47. Panteleeva I, Boutillier S, See V, Spiller D, Rouaux C, Almouzni G, et al. HP1alpha guides neuronal fate by timing E2F-targeted genes silencing during terminal differentiation. EMBO J. 2007;26:3616-28 pubmed
    ..Among the different isoforms, HP1alpha levels progressively increase throughout differentiation and take over HP1gamma binding on E2F sites in mature ..
  48. Katayama K, Furuno A, Akiyama K, Tsuji T, Kunieda T. Characterization of chromosomal inversion of the mouse hairy ears (Eh) mutation associated with cleft palate. Mamm Genome. 2007;18:246-54 pubmed
  49. Naetar N, Hutter S, Dorner D, Dechat T, Korbei B, Gotzmann J, et al. LAP2alpha-binding protein LINT-25 is a novel chromatin-associated protein involved in cell cycle exit. J Cell Sci. 2007;120:737-47 pubmed
    ..Our data show a role of LINT-25 and LAP2alpha during cell cycle exit, in which LINT-25 acts upstream of LAP2alpha. ..
  50. Mandel S, Rechavi G, Gozes I. Activity-dependent neuroprotective protein (ADNP) differentially interacts with chromatin to regulate genes essential for embryogenesis. Dev Biol. 2007;303:814-24 pubmed
    ..These results place ADNP at a crucial point of gene regulation, repressing potential endoderm genes and enhancing genes associated with organogenesis/neurogenesis. ..
  51. Yasuda S, Oceguera Yanez F, Kato T, Okamoto M, Yonemura S, Terada Y, et al. Cdc42 and mDia3 regulate microtubule attachment to kinetochores. Nature. 2004;428:767-71 pubmed
    ..We now show that one member of this family, Cdc42, and its effector, mDia3, regulate MT attachment to kinetochores. ..
  52. Liu J, Yin X, Liu B, Zheng H, Zhou G, Gong L, et al. HP1? mediates defective heterochromatin repair and accelerates senescence in Zmpste24-deficient cells. Cell Cycle. 2014;13:1237-47 pubmed publisher
    Heterochromatin protein 1 (HP1) interacts with various proteins, including lamins, to play versatile functions within nuclei, such as chromatin remodeling and DNA repair...
  53. Allan R, Zueva E, Cammas F, Schreiber H, Masson V, Belz G, et al. An epigenetic silencing pathway controlling T helper 2 cell lineage commitment. Nature. 2012;487:249-53 pubmed publisher
    ..Here we explore the role of the SUV39H1–H3K9me3–HP1? silencing pathway in the control of TH2 lineage stability...
  54. Thliveris A, Clipson L, Sommer L, Schoenike B, Hasenstein J, Schlamp C, et al. Regulated Expression of Chromobox Homolog 5 Revealed in Tumors of Apc(Min) (/+) ROSA11 Gene Trap Mice. G3 (Bethesda). 2012;2:569-78 pubmed publisher
    The gene-trap lacZ reporter insertion, ROSA11, in the Cbx5 mouse gene illuminates the regulatory complexity of this locus in Apc(Min) (/+) mice...
  55. Abe K, Naruse C, Kato T, Nishiuchi T, Saitou M, Asano M. Loss of heterochromatin protein 1 gamma reduces the number of primordial germ cells via impaired cell cycle progression in mice. Biol Reprod. 2011;85:1013-24 pubmed publisher
    ..5. The heterochromatin protein 1 (HP1) family members HP1alpha, HP1beta, and HP1gamma (CBX5, CBX1, and CBX3, respectively) are thought to induce heterochromatin structure and ..
  56. Müller K, Erdel F, Caudron Herger M, Marth C, Fodor B, Richter M, et al. Multiscale analysis of dynamics and interactions of heterochromatin protein 1 by fluorescence fluctuation microscopy. Biophys J. 2009;97:2876-85 pubmed publisher
    ..The local mobility of HP1alpha and HP1beta was investigated in densely packed pericentric heterochromatin foci and compared with other bona fide ..
  57. Meglicki M, Teperek Tkacz M, Borsuk E. Appearance and heterochromatin localization of HP1? in early mouse embryos depends on cytoplasmic clock and H3S10 phosphorylation. Cell Cycle. 2012;11:2189-205 pubmed publisher
    ..b>HP1 (heterochromatin protein 1), a homolog of yeast Swi6, has been shown to be indispensible for proper heterochromatin ..
  58. Dronamraju R, Mason J. MU2 and HP1a regulate the recognition of double strand breaks in Drosophila melanogaster. PLoS ONE. 2011;6:e25439 pubmed publisher
    ..b>HP1a depletion in irradiated imaginal disc cells increases apoptosis and disrupts G2/M arrest...
  59. Friedrich G, Soriano P. Promoter traps in embryonic stem cells: a genetic screen to identify and mutate developmental genes in mice. Genes Dev. 1991;5:1513-23 pubmed
    ..Because no overt phenotype was detected in the remaining strains, these results suggest that a substantial proportion of mammalian genes identified by this approach are not essential for development. ..
  60. Dialynas G, Terjung S, Brown J, Aucott R, Baron Luhr B, Singh P, et al. Plasticity of HP1 proteins in mammalian cells. J Cell Sci. 2007;120:3415-24 pubmed
    ..In parallel, we have interrogated assembly and dynamics of newly expressed HP1-GFP proteins in cells lacking both HP1alpha and HP1beta alleles, blocked at the G1-S boundary, or cultured in the presence of HDAC and HAT inhibitors...
  61. Dan J, Liu Y, Liu N, Chiourea M, Okuka M, Wu T, et al. Rif1 maintains telomere length homeostasis of ESCs by mediating heterochromatin silencing. Dev Cell. 2014;29:7-19 pubmed publisher
    ..Mechanistically, Rif1 interacts and stabilizes H3K9 methylation complex. Thus, Rif1 regulates telomere length homeostasis of ESCs by mediating heterochromatic silencing. ..
  62. Nakagawa C, Kawakita A, Fukada T, Sugimoto K. Live-cell imaging of HP1? throughout the cell cycle of mouse C3H10T1/2 cells and rhythmical flickering of heterochromatin dots in interphase. Biosci Biotechnol Biochem. 2014;78:556-64 pubmed publisher
    b>Heterochromatin protein 1 alpha (HP1?) localizes to heterochromatin in interphase and shows dynamic molecular behavior in living cells...
  63. Grigoryev S, Nikitina T, Pehrson J, Singh P, Woodcock C. Dynamic relocation of epigenetic chromatin markers reveals an active role of constitutive heterochromatin in the transition from proliferation to quiescence. J Cell Sci. 2004;117:6153-62 pubmed
    ..selective changes in localization of two heterochromatin-associated proteins, the histone variant macroH2A and HP1alpha occurred during lymphocyte reactivation...
  64. Sun Y, Wallrabe H, Booker C, Day R, Periasamy A. Three-color spectral FRET microscopy localizes three interacting proteins in living cells. Biophys J. 2010;99:1274-83 pubmed publisher
    ..the dimeric transcription factor C/EBPalpha (expressing mTFP or mVenus) with the heterochromatin protein 1alpha (HP1alpha, expressing tdTomato) in live-mouse pituitary cells...
  65. Wong L, McGhie J, Sim M, Anderson M, Ahn S, Hannan R, et al. ATRX interacts with H3.3 in maintaining telomere structural integrity in pluripotent embryonic stem cells. Genome Res. 2010;20:351-60 pubmed publisher
    ..Moreover, we found that chromobox homolog 5 (CBX5) (also known as heterochromatin protein 1 alpha, or HP1 alpha) is also present at the telomeres in ES cells...