Cbfb

Summary

Gene Symbol: Cbfb
Description: core binding factor beta
Alias: AI893578, PEA2, PEBP2b, Pebp2, Pebpb2, core-binding factor subunit beta, CBF-beta, PEA2-beta, PEBP2-beta, SL3-3 enhancer factor 1 subunit beta, SL3/AKV core-binding factor beta subunit, polyomavirus enhancer-binding protein 2 beta subunit
Species: mouse
Products:     Cbfb

Top Publications

  1. Ogawa E, Inuzuka M, Maruyama M, Satake M, Naito Fujimoto M, Ito Y, et al. Molecular cloning and characterization of PEBP2 beta, the heterodimeric partner of a novel Drosophila runt-related DNA binding protein PEBP2 alpha. Virology. 1993;194:314-31 pubmed
    Polyomavirus enhancer binding protein, PEBP2 (PEA2), is a heterodimer of two distinct subunits, alpha and beta, of which the former directly binds to DNA and the latter acts auxiliary to enhance the DNA binding...
  2. Rudra D, Egawa T, Chong M, Treuting P, Littman D, Rudensky A. Runx-CBFbeta complexes control expression of the transcription factor Foxp3 in regulatory T cells. Nat Immunol. 2009;10:1170-7 pubmed publisher
    ..Thus, Runx-CBFbeta complexes maintain stable high expression of Foxp3 and serve as an essential determinant of T(reg) cell lineage stability. ..
  3. Bae S, Ogawa E, Maruyama M, Oka H, Satake M, Shigesada K, et al. PEBP2 alpha B/mouse AML1 consists of multiple isoforms that possess differential transactivation potentials. Mol Cell Biol. 1994;14:3242-52 pubmed
    ..Both alpha B1 and alpha B2 associate with PEBP2 beta and form a heterodimer...
  4. Tahirov T, Inoue Bungo T, Morii H, Fujikawa A, Sasaki M, Kimura K, et al. Structural analyses of DNA recognition by the AML1/Runx-1 Runt domain and its allosteric control by CBFbeta. Cell. 2001;104:755-67 pubmed
    ..The point mutations of CBFalpha related to the aforementioned diseases were also mapped and their effect on DNA binding is discussed. ..
  5. Egawa T, Littman D. ThPOK acts late in specification of the helper T cell lineage and suppresses Runx-mediated commitment to the cytotoxic T cell lineage. Nat Immunol. 2008;9:1131-9 pubmed publisher
    ..Our results suggest that MHC class II-selected thymocytes are directed toward the CD4(+) lineage independently of ThPOK but require ThPOK to prevent Runx-dependent differentiation toward the CD8(+) lineage. ..
  6. Bae S, Yamaguchi Iwai Y, Ogawa E, Maruyama M, Inuzuka M, Kagoshima H, et al. Isolation of PEBP2 alpha B cDNA representing the mouse homolog of human acute myeloid leukemia gene, AML1. Oncogene. 1993;8:809-14 pubmed
    ..The cDNA isolated from mouse fibroblasts encoding the alpha-subunit of polyomavirus enhancer binding protein 2 (PEBP2/PEA2) revealed that it also has a runt homology region (E. Ogawa et al., submitted)...
  7. Wang S, Wang Q, Crute B, Melnikova I, Keller S, Speck N. Cloning and characterization of subunits of the T-cell receptor and murine leukemia virus enhancer core-binding factor. Mol Cell Biol. 1993;13:3324-39 pubmed
    ..The cDNA clones, which we call CBF beta p22.0, CBF beta p21.5, and CBF beta p17...
  8. Hernandez Munain C, Krangel M. c-Myb and core-binding factor/PEBP2 display functional synergy but bind independently to adjacent sites in the T-cell receptor delta enhancer. Mol Cell Biol. 1995;15:3090-9 pubmed
    ..delta enhancer and that within delta E3, adjacent and precisely spaced binding sites for core-binding factor (CBF/PEBP2) and c-Myb are essential for transcriptional activity...
  9. Wang Q, Stacy T, Miller J, Lewis A, Gu T, Huang X, et al. The CBFbeta subunit is essential for CBFalpha2 (AML1) function in vivo. Cell. 1996;87:697-708 pubmed
    ..Genes encoding the CBFbeta subunit (CBFB) and one of the CBFalpha subunits (CBFA2, otherwise known as AML1) are the most frequent targets of chromosomal ..

More Information

Publications84

  1. Chiba N, Watanabe T, Nomura S, Tanaka Y, Minowa M, Niki M, et al. Differentiation dependent expression and distinct subcellular localization of the protooncogene product, PEBP2beta/CBFbeta, in muscle development. Oncogene. 1997;14:2543-52 pubmed
    The Pebpb2/Cbfb gene encodes the non-DNA binding subunit of the heterodimeric transcription factor, PEBP2/CBF...
  2. Satake M, Nomura S, Yamaguchi Iwai Y, Takahama Y, Hashimoto Y, Niki M, et al. Expression of the Runt domain-encoding PEBP2 alpha genes in T cells during thymic development. Mol Cell Biol. 1995;15:1662-70 pubmed
    The PEBP2 alpha A and PEBP2 alpha B genes encode the DNA-binding subunit of a murine transcription factor, PEBP2, which is implicated as a T-cell-specific transcriptional regulator...
  3. Chong M, Simpson N, Ciofani M, Chen G, Collins A, Littman D. Epigenetic propagation of CD4 expression is established by the Cd4 proximal enhancer in helper T cells. Genes Dev. 2010;24:659-69 pubmed publisher
    ..Thus, E4(P) is responsible for establishing an epigenetically inherited active Cd4 locus in the helper T-cell lineage. To our knowledge, this is the first genetic demonstration of active transcriptional memory in mammalian cells. ..
  4. Setoguchi R, Tachibana M, Naoe Y, Muroi S, Akiyama K, Tezuka C, et al. Repression of the transcription factor Th-POK by Runx complexes in cytotoxic T cell development. Science. 2008;319:822-5 pubmed publisher
    ..Identification of the transcription factors network in CD4 and CD8 lineage choice provides insight into how distinct T cell subsets are developed for regulating the adaptive immune system. ..
  5. Naoe Y, Setoguchi R, Akiyama K, Muroi S, Kuroda M, Hatam F, et al. Repression of interleukin-4 in T helper type 1 cells by Runx/Cbf beta binding to the Il4 silencer. J Exp Med. 2007;204:1749-55 pubmed
    ..Using Cbf beta- or Runx3-deficient T cells, we show that loss of Runx complex function results in derepression of IL-4 in Th1 ..
  6. Yoshida N, Ogata T, Tanabe K, Li S, Nakazato M, Kohu K, et al. Filamin A-bound PEBP2beta/CBFbeta is retained in the cytoplasm and prevented from functioning as a partner of the Runx1 transcription factor. Mol Cell Biol. 2005;25:1003-12 pubmed
    The heterodimeric transcription factor PEBP2/CBF is composed of a DNA-binding subunit, called Runx1, and a non-DNA-binding subunit, called PEBP2beta/CBFbeta...
  7. Ogawa E, Maruyama M, Kagoshima H, Inuzuka M, Lu J, Satake M, et al. PEBP2/PEA2 represents a family of transcription factors homologous to the products of the Drosophila runt gene and the human AML1 gene. Proc Natl Acad Sci U S A. 1993;90:6859-63 pubmed
    cDNAs representing the alpha subunit of polyomavirus enhancer binding protein 2 (PEBP2; also called PEA2) were isolated...
  8. Talebian L, Li Z, Guo Y, Gaudet J, Speck M, Sugiyama D, et al. T-lymphoid, megakaryocyte, and granulocyte development are sensitive to decreases in CBFbeta dosage. Blood. 2007;109:11-21 pubmed
    ..We examined the collective role of core-binding factors in hematopoiesis with a hypomorphic Cbfb allelic series...
  9. Hart S, Foroni L. Core binding factor genes and human leukemia. Haematologica. 2002;87:1307-23 pubmed
    The core binding factor (CBF) transcription complex, consisting of the interacting proteins RUNX1 and CBFb, is essential for normal hematopoiesis...
  10. de Bruijn M, Speck N. Core-binding factors in hematopoiesis and immune function. Oncogene. 2004;23:4238-48 pubmed
    ..transcription factors containing a DNA binding Runx1, Runx2, or Runx3 subunit, along with a non DNA binding CBF beta subunit. All four subunits are required at one or more stages of hematopoiesis...
  11. Kitoh A, Ono M, Naoe Y, Ohkura N, Yamaguchi T, Yaguchi H, et al. Indispensable role of the Runx1-Cbfbeta transcription complex for in vivo-suppressive function of FoxP3+ regulatory T cells. Immunity. 2009;31:609-20 pubmed publisher
    ..b>Cbfb-deleted Treg cells exhibited impaired suppressive function in vitro and in vivo, with altered gene expression ..
  12. Castilla L, Garrett L, Adya N, Orlic D, Dutra A, Anderson S, et al. The fusion gene Cbfb-MYH11 blocks myeloid differentiation and predisposes mice to acute myelomonocytic leukaemia. Nat Genet. 1999;23:144-6 pubmed
  13. Hyde R, Zhao L, Alemu L, Liu P. Runx1 is required for hematopoietic defects and leukemogenesis in Cbfb-MYH11 knock-in mice. Leukemia. 2015;29:1771-8 pubmed publisher
    ..smooth muscle myosin heavy chain), the fusion protein generated by the chromosome 16 inversion fusion gene, CBFB-MYH11, is known to initiate leukemogenesis...
  14. Park N, Lim K, Han M, Che X, Park C, Kim J, et al. Core Binding Factor β Plays a Critical Role During Chondrocyte Differentiation. J Cell Physiol. 2016;231:162-71 pubmed publisher
    ..Here we address the role of Cbfβ in cartilage by generating chondrocyte-specific Cbfβ-deficient mice (Cbfb(Δch/Δch) ) from Cbfb-floxed mice crossed with mice expressing Cre from the Col2a1 promoter...
  15. Nagatake T, Fukuyama S, Sato S, Okura H, Tachibana M, Taniuchi I, et al. Central Role of Core Binding Factor β2 in Mucosa-Associated Lymphoid Tissue Organogenesis in Mouse. PLoS ONE. 2015;10:e0127460 pubmed publisher
    ..These findings demonstrate that Cbfβ2 is a central regulator of the MALT developmental program, but the dependency of Runx proteins on the lymphoid tissue development would differ among PPs, NALT, and TALT. ..
  16. Park S, Lim J, Kang C. Crlz1 activates transcription by mobilizing cytoplasmic CBFbeta into the nucleus. Biochim Biophys Acta. 2009;1789:702-8 pubmed publisher
  17. Chen W, Ma J, Zhu G, Jules J, Wu M, McConnell M, et al. Cbf? deletion in mice recapitulates cleidocranial dysplasia and reveals multiple functions of Cbf? required for skeletal development. Proc Natl Acad Sci U S A. 2014;111:8482-7 pubmed publisher
    ..These insights into the role of Cbf? in postnatal skeletogenesis and CCD pathogenesis may assist in the development of new therapies for CCD and osteoporosis. ..
  18. Kobayashi M, Shelley W, Seo W, Vemula S, Lin Y, Liu Y, et al. Functional B-1 progenitor cells are present in the hematopoietic stem cell-deficient embryo and depend on Cbf? for their development. Proc Natl Acad Sci U S A. 2014;111:12151-6 pubmed publisher
    ..Our data provide, to our knowledge, the first evidence for the presence of B-1 progenitor cells in the fetal liver that arise independently of HSCs and implicate Cbf? as a critical molecule in the development of this lineage. ..
  19. Zhen T, Kwon E, Zhao L, Hsu J, Hyde R, Lu Y, et al. Chd7 deficiency delays leukemogenesis in mice induced by Cbfb-MYH11. Blood. 2017;130:2431-2442 pubmed publisher
    ..is a consistent finding in patients with acute myeloid leukemia subtype M4 with eosinophilia, which generates a CBFB-MYH11 fusion gene...
  20. Jiang Q, Qin X, Kawane T, Komori H, Matsuo Y, Taniuchi I, et al. Cbfb2 Isoform Dominates More Potent Cbfb1 and Is Required for Skeletal Development. J Bone Miner Res. 2016;31:1391-404 pubmed publisher
    b>Cbfb is a cotranscription factor that forms a heterodimer with Runx proteins Runx1, Runx2, and Runx3. It is required for fetal liver hematopoiesis and skeletal development...
  21. Okada H, Watanabe T, Niki M, Takano H, Chiba N, Yanai N, et al. AML1(-/-) embryos do not express certain hematopoiesis-related gene transcripts including those of the PU.1 gene. Oncogene. 1998;17:2287-93 pubmed
    ..genes encode the DNA-binding and non-binding subunits, respectively, of the heterodimeric transcription factor, PEBP2/CBF...
  22. Huang G, Shigesada K, Ito K, Wee H, Yokomizo T, Ito Y. Dimerization with PEBP2beta protects RUNX1/AML1 from ubiquitin-proteasome-mediated degradation. EMBO J. 2001;20:723-33 pubmed
    ..The RUNX genes encode the alpha subunit of the transcription factor PEBP2/CBF. The beta subunit consists of the non-RUNX protein PEBP2beta...
  23. Wang C, Chin D, Chooi J, Chng W, Taniuchi I, Tergaonkar V, et al. Cbfb deficiency results in differentiation blocks and stem/progenitor cell expansion in hematopoiesis. Leukemia. 2015;29:753-7 pubmed publisher
  24. Kundu M, Chen A, Anderson S, Kirby M, Xu L, Castilla L, et al. Role of Cbfb in hematopoiesis and perturbations resulting from expression of the leukemogenic fusion gene Cbfb-MYH11. Blood. 2002;100:2449-56 pubmed
    ..Inv(16)(p13;q22) is found in almost all cases of AML M4Eo and results in the fusion of CBFB with MYH11, the gene encoding smooth muscle myosin heavy chain...
  25. Kuo Y, Landrette S, Heilman S, Perrat P, Garrett L, Liu P, et al. Cbf beta-SMMHC induces distinct abnormal myeloid progenitors able to develop acute myeloid leukemia. Cancer Cell. 2006;9:57-68 pubmed
    The acute myeloid leukemia (AML)-associated CBF beta-SMMHC fusion protein impairs hematopoietic differentiation and predisposes to leukemic transformation. The mechanism of leukemia progression, however, is poorly understood...
  26. Collins A, Hewitt S, Chaumeil J, Sellars M, Micsinai M, Allinne J, et al. RUNX transcription factor-mediated association of Cd4 and Cd8 enables coordinate gene regulation. Immunity. 2011;34:303-14 pubmed publisher
    ..Communication between Cd4 and Cd8 thus appears to enable long-range epigenetic regulation to ensure that expression of one excludes the other in mature CD4 or CD8 single-positive (SP) cells. ..
  27. Kanatani N, Fujita T, Fukuyama R, Liu W, Yoshida C, Moriishi T, et al. Cbf beta regulates Runx2 function isoform-dependently in postnatal bone development. Dev Biol. 2006;296:48-61 pubmed
    ..On luciferase and electrophoretic mobility shift assays, Runx2-I was less active than Runx2-II in the absence of Cbfb, but the two Runx2 isoforms had similar activity levels in the presence of Cbfb...
  28. Yokomizo T, Takahashi S, Mochizuki N, Kuroha T, Ema M, Wakamatsu A, et al. Characterization of GATA-1(+) hemangioblastic cells in the mouse embryo. EMBO J. 2007;26:184-96 pubmed
    ..These results provide evidence of the presence of GATA-1(+) hemangioblastic cells in the extra-embryonic region and also their functional contribution to hematopoiesis in the embryo. ..
  29. Cai Q, Jeannet R, Hua W, Cook G, Zhang B, Qi J, et al. CBF?-SMMHC creates aberrant megakaryocyte-erythroid progenitors prone to leukemia initiation in mice. Blood. 2016;128:1503-15 pubmed publisher
    ..Abnormality in Meg/E or erythroid progenitors could potentially be considered an early predictive risk factor for leukemia evolution. ..
  30. Heilman S, Kuo Y, Goudswaard C, Valk P, Castilla L. Cbfbeta reduces Cbfbeta-SMMHC-associated acute myeloid leukemia in mice. Cancer Res. 2006;66:11214-8 pubmed
  31. Hossain D, Dos Santos C, Zhang Q, Kozlowska A, Liu H, Gao C, et al. Leukemia cell-targeted STAT3 silencing and TLR9 triggering generate systemic antitumor immunity. Blood. 2014;123:15-25 pubmed publisher
    ..We used mouse Cbfb-MYH11/Mpl-induced leukemia model, which mimics human inv(16) AML...
  32. Xue L, Pulikkan J, Valk P, Castilla L. NrasG12D oncoprotein inhibits apoptosis of preleukemic cells expressing Cbf?-SMMHC via activation of MEK/ERK axis. Blood. 2014;124:426-36 pubmed publisher
    ..Here, we used Nras(LSL-G12D); Cbfb(56M) knock-in mice to show that allelic expression of oncogenic Nras(G12D) and Cbf?-SMMHC increases survival of ..
  33. Cunningham L, Finckbeiner S, Hyde R, Southall N, Marugan J, Yedavalli V, et al. Identification of benzodiazepine Ro5-3335 as an inhibitor of CBF leukemia through quantitative high throughput screen against RUNX1-CBF? interaction. Proc Natl Acad Sci U S A. 2012;109:14592-7 pubmed publisher
    ..factor (CBF) leukemias, those with translocations or inversions that affect transcription factor genes RUNX1 or CBFB, account for ~24% of adult acute myeloid leukemia (AML) and 25% of pediatric acute lymphocytic leukemia (ALL)...
  34. Wolf Watz M, Grundstrom T, Hard T. Structure and backbone dynamics of Apo-CBFbeta in solution. Biochemistry. 2001;40:11423-32 pubmed
    ..The comparison illustrates that independently determined NMR structures may display rather large differences in backbone conformation in regions that appear to be well-defined in each of the calculated NMR ensembles. ..
  35. Kamikubo Y, Zhao L, Wunderlich M, Corpora T, Hyde R, Paul T, et al. Accelerated leukemogenesis by truncated CBF beta-SMMHC defective in high-affinity binding with RUNX1. Cancer Cell. 2010;17:455-68 pubmed publisher
    Dominant RUNX1 inhibition has been proposed as a common pathway for CBF leukemia. CBF beta-SMMHC, a fusion protein in human acute myeloid leukemia (AML), dominantly inhibits RUNX1 largely through its RUNX1 high-affinity binding domain (..
  36. Zhang L, Li Z, Yan J, Pradhan P, Corpora T, Cheney M, et al. Mutagenesis of the Runt domain defines two energetic hot spots for heterodimerization with the core binding factor beta subunit. J Biol Chem. 2003;278:33097-104 pubmed
    ..CBFs consist of a DNA-binding CBF alpha subunit (Runx1, Runx2, or Runx3) and a non-DNA-binding CBF beta subunit. CBF alpha binds DNA in a sequence-specific manner, whereas CBF beta enhances DNA binding by CBF alpha...
  37. Tian F, Wu M, Deng L, Zhu G, Ma J, Gao B, et al. Core binding factor beta (Cbf?) controls the balance of chondrocyte proliferation and differentiation by upregulating Indian hedgehog (Ihh) expression and inhibiting parathyroid hormone-related protein receptor (PPR) expression in postnatal cartilage. J Bone Miner Res. 2014;29:1564-1574 pubmed publisher
  38. Goyama S, Schibler J, Cunningham L, Zhang Y, Rao Y, Nishimoto N, et al. Transcription factor RUNX1 promotes survival of acute myeloid leukemia cells. J Clin Invest. 2013;123:3876-88 pubmed publisher
    ..Using a mouse genetic model, we also showed that the combined loss of Runx1/Cbfb inhibited leukemia development induced by MLL-AF9. RUNX2 could compensate for the loss of RUNX1...
  39. Seo W, Ikawa T, Kawamoto H, Taniuchi I. Runx1-Cbf? facilitates early B lymphocyte development by regulating expression of Ebf1. J Exp Med. 2012;209:1255-62 pubmed publisher
    ..Collectively, these results demonstrate that Runx1-Cbf? complexes are essential to facilitate B lineage specification, in part via epigenetic activation of the Ebf1 gene. ..
  40. Vacchio M, Wang L, Bouladoux N, Carpenter A, Xiong Y, Williams L, et al. A ThPOK-LRF transcriptional node maintains the integrity and effector potential of post-thymic CD4+ T cells. Nat Immunol. 2014;15:947-56 pubmed publisher
    ..As such, the ThPOK-LRF transcriptional module was essential for CD4(+) T cell integrity and responses. ..
  41. Bernardin F, Yang Y, Civin C, Friedman A. c-Myc overcomes cell cycle inhibition by CBFbeta-SMMHC, a myeloid leukemia oncoprotein. Cancer Biol Ther. 2002;1:492-6 pubmed
    ..In a subset of CBF leukemias, elevated expression of c-Myc is expected to facilitate the proliferation of the leukemic blasts and thereby potentiate the ability of CBF oncoproteins to block differentiation. ..
  42. Takarada T, Yoneda Y. Transactivation by Runt related factor-2 of matrix metalloproteinase-13 in astrocytes. Neurosci Lett. 2009;451:99-104 pubmed publisher
    ..These results suggest that Runx2 signal input may lead to transactivation of MMP13 gene without affecting OPN expression in astrocytes. ..
  43. Yokomizo T, Yanagida M, Huang G, Osato M, Honda C, Ema M, et al. Genetic evidence of PEBP2beta-independent activation of Runx1 in the murine embryo. Int J Hematol. 2008;88:134-138 pubmed publisher
    ..5-12.5, although definitive hematopoiesis was not restored. Thus, PEBP2beta-independent Runx1 activation can occur in vivo. This observation sheds new light on the mechanism(s) that regulate the activity of Runx transcription factors. ..
  44. Guo Y, Maillard I, Chakraborti S, Rothenberg E, Speck N. Core binding factors are necessary for natural killer cell development and cooperate with Notch signaling during T-cell specification. Blood. 2008;112:480-92 pubmed publisher
    ..Therefore, the ability of the prethymic cell to respond appropriately to Notch is dependent on CBFbeta, and both signals converge to activate the T-cell developmental program. ..
  45. Hyde R, Kamikubo Y, Anderson S, Kirby M, Alemu L, Zhao L, et al. Cbfb/Runx1 repression-independent blockage of differentiation and accumulation of Csf2rb-expressing cells by Cbfb-MYH11. Blood. 2010;115:1433-43 pubmed publisher
    It is known that CBFB-MYH11, the fusion gene generated by inversion of chromosome 16 in human acute myeloid leukemia, is causative for oncogenic transformation...
  46. Lim K, Park N, Che X, Han M, Jeong J, Kim S, et al. Core binding factor β of osteoblasts maintains cortical bone mass via stabilization of Runx2 in mice. J Bone Miner Res. 2015;30:715-22 pubmed publisher
    ..Null mutations of Cbfb result in embryonic death, which can be rescued by restoring fetal hematopoiesis but only until birth, where bone ..
  47. Yergeau D, Hetherington C, Wang Q, Zhang P, Sharpe A, Binder M, et al. Embryonic lethality and impairment of haematopoiesis in mice heterozygous for an AML1-ETO fusion gene. Nat Genet. 1997;15:303-6 pubmed
    ..This phenotype is very similar to that resulting from homozygous disruption of the AML1 (Cbfa2) or Cbfb genes, indicating that AML1-ETO blocks normal AML1 function...
  48. Huang S, O Donovan K, Turner E, Zhong J, Ginty D. Extrinsic and intrinsic signals converge on the Runx1/CBFβ transcription factor for nonpeptidergic nociceptor maturation. elife. 2015;4:e10874 pubmed publisher
    ..NGF signals through the ERK/MAPK pathway to promote expression of Cbfb but not Runx1 prior to maturation of nonpeptidergic nociceptors...
  49. Boucheron N, Tschismarov R, Goeschl L, Moser M, Lagger S, Sakaguchi S, et al. CD4(+) T cell lineage integrity is controlled by the histone deacetylases HDAC1 and HDAC2. Nat Immunol. 2014;15:439-448 pubmed publisher
    ..These results demonstrate that HDAC1 and HDAC2 maintain integrity of the CD4 lineage by repressing Runx-CBF? complexes that otherwise induce a CD8(+) effector T cell-like program in CD4(+) T cells. ..
  50. Choi S, Park S, Yoo H, Pi J, Kang C. Charged Amino Acid-rich Leucine Zipper-1 (Crlz-1) as a Target of Wnt Signaling Pathway Controls Pre-B Cell Proliferation by Affecting Runx/CBF?-targeted VpreB and ?5 Genes. J Biol Chem. 2016;291:15008-19 pubmed publisher
  51. Dos Santos C, McDonald T, Ho Y, Liu H, Lin A, Forman S, et al. The Src and c-Kit kinase inhibitor dasatinib enhances p53-mediated targeting of human acute myeloid leukemia stem cells by chemotherapeutic agents. Blood. 2013;122:1900-13 pubmed publisher
    ..Combined treatment using dasatinib and chemotherapy provides a novel approach to increasing p53 activity and enhancing targeting of AML stem cells. ..
  52. Matsui Y, Shindo K, Nagata K, Yoshinaga N, Shirakawa K, Kobayashi M, et al. Core Binding Factor ? Protects HIV, Type 1 Accessory Protein Viral Infectivity Factor from MDM2-mediated Degradation. J Biol Chem. 2016;291:24892-24899 pubmed
    ..Our data provide new insights into the mechanism of Vif augmentation by CBF?. ..
  53. Sakuma T, Li Q, Jin Y, Choi L, Kim E, Ito K, et al. Cloning and expression pattern of a novel PEBP2 beta-binding protein (charged amino acid rich leucine zipper-1[Crl-1]) in the mouse. Mech Dev. 2001;104:151-4 pubmed
    b>PEBP2 beta/Cbf beta is the beta subunit of PEBP2/Cbf, which has been demonstrated to have important biological activities in hematopoiesis and osteogenesis...
  54. Huang X, Peng J, Speck N, Bushweller J. Solution structure of core binding factor beta and map of the CBF alpha binding site. Nat Struct Biol. 1999;6:624-7 pubmed
    The core binding factor beta subunit (CBF beta) is the non-DNA binding subunit of the core-binding factors, transcription factors essential for multiple developmental processes including hematopoiesis and bone development...
  55. Satpathy A, Briseño C, Cai X, Michael D, Chou C, Hsiung S, et al. Runx1 and Cbf? regulate the development of Flt3+ dendritic cell progenitors and restrict myeloproliferative disorder. Blood. 2014;123:2968-77 pubmed publisher
    ..Besides the loss of DC progenitors, pan-hematopoietic Cbfb-deficient mice also lack CD105(+) erythroid progenitors, leading to severe anemia at 3 to 4 months of age...
  56. Zhao L, Cannons J, Anderson S, Kirby M, Xu L, Castilla L, et al. CBFB-MYH11 hinders early T-cell development and induces massive cell death in the thymus. Blood. 2007;109:3432-40 pubmed
    ..If this is the case, it is of interest to know the effects of the resulting fusion gene, CBFB-MYH11, on other lineages...
  57. Sleckman B, Khan W, Xu W, Bassing C, Malynn B, Copeland N, et al. Cloning and functional characterization of the early-lymphocyte-specific Pb99 gene. Mol Cell Biol. 2000;20:4405-10 pubmed
    ..To directly address the role of the Pb99 protein in lymphoid development, Pb99-deficient mice were generated by gene targeting, and lymphocyte development in these mice was analyzed. ..
  58. Lauzurica P, Zhong X, Krangel M, Roberts J. Regulation of T cell receptor delta gene rearrangement by CBF/PEBP2. J Exp Med. 1997;185:1193-201 pubmed
    ..We tested whether the transcription factor CBF/PEBP2 plays an important role in the ability of E(delta) to activate VDJ recombination by analyzing VDJ recombination in ..
  59. Philipot O, Joliot V, Ait Mohamed O, Pellentz C, Robin P, Fritsch L, et al. The core binding factor CBF negatively regulates skeletal muscle terminal differentiation. PLoS ONE. 2010;5:e9425 pubmed publisher
    Core Binding Factor or CBF is a transcription factor composed of two subunits, Runx1/AML-1 and CBF beta or CBFbeta. CBF was originally described as a regulator of hematopoiesis...
  60. Kundu M, Liu P. Cbf beta is involved in maturation of all lineages of hematopoietic cells during embryogenesis except erythroid. Blood Cells Mol Dis. 2003;30:164-9 pubmed
    The transcription factor Cbf beta forms a heterodimeric complex with members of the Runx family of proteins. Together, Cbf beta and Runx1 play a critical role in the establishment of definitive hematopoiesis in mouse embryos...
  61. Wilson K, Park J, Curry T, Mishra B, Gossen J, Taniuchi I, et al. Core Binding Factor-? Knockdown Alters Ovarian Gene Expression and Function in the Mouse. Mol Endocrinol. 2016;30:733-47 pubmed publisher
    ..and transcriptome assembly revealed altered expression of more than 200 mRNA transcripts in the granulosa cells of Cbfb knockdown mice after human chorionic gonadotropin stimulation in vitro...
  62. Castilla L, Perrat P, Martinez N, Landrette S, Keys R, Oikemus S, et al. Identification of genes that synergize with Cbfb-MYH11 in the pathogenesis of acute myeloid leukemia. Proc Natl Acad Sci U S A. 2004;101:4924-9 pubmed
    ..leukemia subtype M4 with eosinophilia is associated with a chromosome 16 inversion that creates a fusion gene CBFB-MYH11. We have previously shown that CBFB-MYH11 is necessary but not sufficient for leukemogenesis...
  63. Islam M, Itoh S, Yanagita T, Sumiyoshi K, Hayano S, Kuremoto K, et al. Runx/Cbfb signaling regulates postnatal development of granular convoluted tubule in the mouse submandibular gland. Dev Dyn. 2015;244:488-96 pubmed publisher
    ..Core binding factor β (Cbfb) is a cotranscription factor which forms a heterodimer with Runx proteins...
  64. Miller J, Horner A, Stacy T, Lowrey C, Lian J, Stein G, et al. The core-binding factor beta subunit is required for bone formation and hematopoietic maturation. Nat Genet. 2002;32:645-9 pubmed
    ..5 significant impairments in lymphopoiesis and myelopoiesis are observed. Thus, we conclude that the Cbfbeta subunit is required for HSC emergence, bone formation and normal differentiation of lymphoid and myeloid lineage cells. ..
  65. Landrette S, Kuo Y, Hensen K, Barjesteh van Waalwijk van Doorn Khosrovani S, Perrat P, Van de Ven W, et al. Plag1 and Plagl2 are oncogenes that induce acute myeloid leukemia in cooperation with Cbfb-MYH11. Blood. 2005;105:2900-7 pubmed
    ..A recent genetic screen identified Plag1 and Plagl2 as CBF beta-SMMHC candidate cooperating proteins...
  66. Wang C, Krishnan V, Tay L, Chin D, Koh C, Chooi J, et al. Disruption of Runx1 and Runx3 leads to bone marrow failure and leukemia predisposition due to transcriptional and DNA repair defects. Cell Rep. 2014;8:767-82 pubmed publisher
    ..These findings suggest that RUNX dysfunction causes DNA repair defect, besides transcriptional misregulation, and promotes the development of leukemias and other cancers. ..
  67. Kundu M, Javed A, Jeon J, Horner A, Shum L, Eckhaus M, et al. Cbfbeta interacts with Runx2 and has a critical role in bone development. Nat Genet. 2002;32:639-44 pubmed
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