Gene Symbol: CB1
Description: cannabinoid receptor 1 (brain)
Alias: CB-R, CB1, CB1R, cannabinoid receptor 1, brain-type cannabinoid receptor, striatal cannabinoid receptor type 1 protein
Species: mouse
Products:     CB1

Top Publications

  1. Monory K, Massa F, Egertová M, Eder M, Blaudzun H, Westenbroek R, et al. The endocannabinoid system controls key epileptogenic circuits in the hippocampus. Neuron. 2006;51:455-66 pubmed
    ..Functional CB1 cannabinoid receptors are present on glutamatergic terminals of the hippocampal formation, colocalizing with ..
  2. Rozenfeld R, Gupta A, Gagnidze K, Lim M, Gomes I, Lee Ramos D, et al. AT1R-CB?R heteromerization reveals a new mechanism for the pathogenic properties of angiotensin II. EMBO J. 2011;30:2350-63 pubmed publisher
    ..These results provide a molecular basis for the pivotal role of heteromer-dependent signal integration in pathology. ..
  3. Dubreucq S, Koehl M, Abrous D, Marsicano G, Chaouloff F. CB1 receptor deficiency decreases wheel-running activity: consequences on emotional behaviours and hippocampal neurogenesis. Exp Neurol. 2010;224:106-13 pubmed publisher
    Chronic voluntary wheel-running activity has been reported to hypersensitise central CB1 receptors in mice...
  4. Cota D, Steiner M, Marsicano G, Cervino C, Herman J, Grubler Y, et al. Requirement of cannabinoid receptor type 1 for the basal modulation of hypothalamic-pituitary-adrenal axis function. Endocrinology. 2007;148:1574-81 pubmed
    ..Here we demonstrate that mice lacking cannabinoid receptor type 1 (CB1-/-) display a significant dysregulation of the HPA axis...
  5. Holter S, Kallnik M, Wurst W, Marsicano G, Lutz B, Wotjak C. Cannabinoid CB1 receptor is dispensable for memory extinction in an appetitively-motivated learning task. Eur J Pharmacol. 2005;510:69-74 pubmed
    ..To this end, male cannabinoid CB1 receptor deficient mice (CB1R-/-) and their wild-type littermate controls (CB1R+/+) were trained in an appetitively-motivated operant ..
  6. Puighermanal E, Marsicano G, Busquets Garcia A, Lutz B, Maldonado R, Ozaita A. Cannabinoid modulation of hippocampal long-term memory is mediated by mTOR signaling. Nat Neurosci. 2009;12:1152-8 pubmed publisher
    ..We found that CB1 cannabinoid receptor (CB1R) activation transiently modulated the mammalian target of rapamycin (mTOR)/p70S6K pathway and the protein synthesis ..
  7. Keimpema E, Barabas K, Morozov Y, Tortoriello G, Torii M, Cameron G, et al. Differential subcellular recruitment of monoacylglycerol lipase generates spatial specificity of 2-arachidonoyl glycerol signaling during axonal pathfinding. J Neurosci. 2010;30:13992-4007 pubmed publisher
  8. Cristino L, De Petrocellis L, Pryce G, Baker D, Guglielmotti V, Di Marzo V. Immunohistochemical localization of cannabinoid type 1 and vanilloid transient receptor potential vanilloid type 1 receptors in the mouse brain. Neuroscience. 2006;139:1405-15 pubmed
    ..These data support the hypothesis of a functional relationship between the two receptor types in the CNS. ..
  9. Terzian A, Drago F, Wotjak C, Micale V. The Dopamine and Cannabinoid Interaction in the Modulation of Emotions and Cognition: Assessing the Role of Cannabinoid CB1 Receptor in Neurons Expressing Dopamine D1 Receptors. Front Behav Neurosci. 2011;5:49 pubmed publisher
    ..We used conditional CB1R knock-out animals lacking CB1Rs in neurons expressing D1R (D1-CB1(-/-)) in order to answer this question...

More Information


  1. Bellocchio L, Soria Gomez E, Quarta C, Metna Laurent M, Cardinal P, Binder E, et al. Activation of the sympathetic nervous system mediates hypophagic and anxiety-like effects of CB? receptor blockade. Proc Natl Acad Sci U S A. 2013;110:4786-91 pubmed publisher
    Complex interactions between periphery and the brain regulate food intake in mammals. Cannabinoid type-1 (CB1) receptor antagonists are potent hypophagic agents, but the sites where this acute action is exerted and the underlying ..
  2. Nakata M, Yada T. Cannabinoids inhibit insulin secretion and cytosolic Ca2+ oscillation in islet beta-cells via CB1 receptors. Regul Pept. 2008;145:49-53 pubmed
    ..Endogenous cannabinoids act on the cannabinoid type 1 (CB1) receptor, a GPCR, and stimulate appetite via central and peripheral actions, while blockade of CB1 receptor ..
  3. Köfalvi A, Rodrigues R, Ledent C, Mackie K, Vizi E, Cunha R, et al. Involvement of cannabinoid receptors in the regulation of neurotransmitter release in the rodent striatum: a combined immunochemical and pharmacological analysis. J Neurosci. 2005;25:2874-84 pubmed
    ..potential in Parkinson's and Huntington's diseases, the cellular and subcellular distributions of striatal CB1 receptors are not well defined...
  4. Quarta C, Bellocchio L, Mancini G, Mazza R, Cervino C, Braulke L, et al. CB(1) signaling in forebrain and sympathetic neurons is a key determinant of endocannabinoid actions on energy balance. Cell Metab. 2010;11:273-85 pubmed publisher
    ..In conclusion, CB(1) signaling in the forebrain and sympathetic neurons is a key determinant of the ECS control of energy balance. ..
  5. Thiemann G, Fletcher B, Ledent C, Molleman A, Hasenöhrl R. The genetic versus pharmacological invalidation of the cannabinoid CB(1) receptor results in differential effects on 'non-associative' memory and forebrain monoamine concentrations in mice. Neurobiol Learn Mem. 2007;88:416-23 pubmed
  6. Guggenhuber S, Monory K, Lutz B, Klugmann M. AAV vector-mediated overexpression of CB1 cannabinoid receptor in pyramidal neurons of the hippocampus protects against seizure-induced excitoxicity. PLoS ONE. 2010;5:e15707 pubmed publisher
    The CB1 cannabinoid receptor is the most abundant G-protein coupled receptor in the brain and a key regulator of neuronal excitability...
  7. Pan B, Hillard C, Liu Q. D2 dopamine receptor activation facilitates endocannabinoid-mediated long-term synaptic depression of GABAergic synaptic transmission in midbrain dopamine neurons via cAMP-protein kinase A signaling. J Neurosci. 2008;28:14018-30 pubmed publisher
  8. Jacob W, Yassouridis A, Marsicano G, Monory K, Lutz B, Wotjak C. Endocannabinoids render exploratory behaviour largely independent of the test aversiveness: role of glutamatergic transmission. Genes Brain Behav. 2009;8:685-98 pubmed publisher
    ..in the regulation of exploratory behaviour, we tested conventional and conditional cannabinoid receptor type 1 (CB1)-deficient mice in behavioural paradigms with different emotional load, which depended on the strength of ..
  9. Argaw A, Duff G, Zabouri N, Cécyre B, Chainé N, Cherif H, et al. Concerted action of CB1 cannabinoid receptor and deleted in colorectal cancer in axon guidance. J Neurosci. 2011;31:1489-99 pubmed publisher
    ..The presence of eCBs, their CB1 receptor (CB1R), and metabolizing enzymes at embryonic and early postnatal periods have been linked to developmental processes ..
  10. Kamprath K, Plendl W, Marsicano G, Deussing J, Wurst W, Lutz B, et al. Endocannabinoids mediate acute fear adaptation via glutamatergic neurons independently of corticotropin-releasing hormone signaling. Genes Brain Behav. 2009;8:203-11 pubmed publisher
  11. Tam J, Vemuri V, Liu J, Batkai S, Mukhopadhyay B, Godlewski G, et al. Peripheral CB1 cannabinoid receptor blockade improves cardiometabolic risk in mouse models of obesity. J Clin Invest. 2010;120:2953-66 pubmed publisher
    ..Cannabinoid-1 receptor (CB1R) antagonists reduce body weight and improve cardiometabolic abnormalities in experimental and human obesity, but ..
  12. Storr M, Keenan C, Emmerdinger D, Zhang H, Yüce B, Sibaev A, et al. Targeting endocannabinoid degradation protects against experimental colitis in mice: involvement of CB1 and CB2 receptors. J Mol Med (Berl). 2008;86:925-36 pubmed publisher
    ..In conclusion, drugs targeting EC degradation offer therapeutic potential in the treatment of inflammatory bowel diseases. Furthermore, reduction of FAAH mRNA expression is involved in the pathophysiological response to colitis. ..
  13. Wittmann G, Deli L, Kallo I, Hrabovszky E, Watanabe M, Liposits Z, et al. Distribution of type 1 cannabinoid receptor (CB1)-immunoreactive axons in the mouse hypothalamus. J Comp Neurol. 2007;503:270-9 pubmed
    Type 1 cannabinoid receptor (CB1) is the principal receptor for endocannabinoids in the brain; it mainly occurs in preterminal/terminal axons and mediates retrograde neuronal signaling mechanisms...
  14. Rossi S, Furlan R, De Chiara V, Muzio L, Musella A, Motta C, et al. Cannabinoid CB1 receptors regulate neuronal TNF-? effects in experimental autoimmune encephalomyelitis. Brain Behav Immun. 2011;25:1242-8 pubmed publisher
    ..The mechanism by which CB1R stimulation exerts protective effects is still unclear...
  15. Bromberg K, Ma ayan A, Neves S, Iyengar R. Design logic of a cannabinoid receptor signaling network that triggers neurite outgrowth. Science. 2008;320:903-9 pubmed publisher
    b>Cannabinoid receptor 1 (CB1R) regulates neuronal differentiation...
  16. Kawamura Y, Fukaya M, Maejima T, Yoshida T, Miura E, Watanabe M, et al. The CB1 cannabinoid receptor is the major cannabinoid receptor at excitatory presynaptic sites in the hippocampus and cerebellum. J Neurosci. 2006;26:2991-3001 pubmed
    ..It is generally accepted that the CB1 cannabinoid receptor (CB1) mediates the effects of endocannabinoid in inhibitory synapses...
  17. Vitalis T, Laine J, Simon A, Roland A, Leterrier C, Lenkei Z. The type 1 cannabinoid receptor is highly expressed in embryonic cortical projection neurons and negatively regulates neurite growth in vitro. Eur J Neurosci. 2008;28:1705-18 pubmed publisher
  18. Osei Hyiaman D, DePetrillo M, Pacher P, Liu J, Radaeva S, Batkai S, et al. Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity. J Clin Invest. 2005;115:1298-305 pubmed
    ..We conclude that anandamide acting at hepatic CB(1) contributes to diet-induced obesity and that the FAS pathway may be a common molecular target for central appetitive and peripheral metabolic regulation. ..
  19. South T, Huang X. Temporal and site-specific brain alterations in CB1 receptor binding in high fat diet-induced obesity in C57Bl/6 mice. J Neuroendocrinol. 2008;20:1288-94 pubmed publisher
    The cannabinoid CB1 receptor has been implicated in the regulation of appetite and the consumption of palatable foods...
  20. Pang Z, Wu N, Zhao W, Chain D, Schaffer E, Zhang X, et al. The central cannabinoid CB1 receptor is required for diet-induced obesity and rimonabant's antiobesity effects in mice. Obesity (Silver Spring). 2011;19:1923-34 pubmed publisher
    Cannabinoid receptor CB1 is expressed abundantly in the brain and presumably in the peripheral tissues responsible for energy metabolism...
  21. Sigel E, Baur R, Racz I, Marazzi J, Smart T, Zimmer A, et al. The major central endocannabinoid directly acts at GABA(A) receptors. Proc Natl Acad Sci U S A. 2011;108:18150-5 pubmed publisher
    ..The identification of a functional binding site for 2-AG in the GABA(A) receptor may have far-reaching consequences for the study of locomotion and sedation. ..
  22. Díaz Alonso J, Aguado T, Wu C, Palazuelos J, Hofmann C, Garcez P, et al. The CB(1) cannabinoid receptor drives corticospinal motor neuron differentiation through the Ctip2/Satb2 transcriptional regulation axis. J Neurosci. 2012;32:16651-65 pubmed publisher
  23. Tiyerili V, Zimmer S, Jung S, Wassmann K, Naehle C, Lutjohann D, et al. CB1 receptor inhibition leads to decreased vascular AT1 receptor expression, inhibition of oxidative stress and improved endothelial function. Basic Res Cardiol. 2010;105:465-77 pubmed publisher
    ..This antioxidative effect is associated with improved endothelial function in ApoE-/- mice, indicating beneficial direct vascular effects of CB(1)-R inhibition. ..
  24. Wang H, Guo Y, Wang D, Kingsley P, Marnett L, Das S, et al. Aberrant cannabinoid signaling impairs oviductal transport of embryos. Nat Med. 2004;10:1074-80 pubmed
    ..Here we show that genetic or pharmacologic silencing of cannabinoid receptor CB1 causes retention of a large number of embryos in the mouse oviduct, eventually leading to pregnancy failure...
  25. Monory K, Blaudzun H, Massa F, Kaiser N, Lemberger T, Schutz G, et al. Genetic dissection of behavioural and autonomic effects of Delta(9)-tetrahydrocannabinol in mice. PLoS Biol. 2007;5:e269 pubmed
    ..THC) exert a plethora of psychoactive effects through the activation of the neuronal cannabinoid receptor type 1 (CB1), which is expressed by different neuronal subpopulations in the central nervous system...
  26. Jeong W, Osei Hyiaman D, Park O, Liu J, Batkai S, Mukhopadhyay P, et al. Paracrine activation of hepatic CB1 receptors by stellate cell-derived endocannabinoids mediates alcoholic fatty liver. Cell Metab. 2008;7:227-35 pubmed publisher
    ..the steatosis induced in mice by a low-fat, liquid ethanol diet is attenuated by concurrent blockade of cannabinoid CB1 receptors...
  27. Li C, Bowe J, Jones P, Persaud S. Expression and function of cannabinoid receptors in mouse islets. Islets. 2010;2:293-302 pubmed
    The endocannabinoid system plays a key role in energy homeostasis, with agonists and antagonists of CB1 receptors acting centrally to stimulate and inhibit food intake, respectively...
  28. Aguado T, Romero E, Monory K, Palazuelos J, Sendtner M, Marsicano G, et al. The CB1 cannabinoid receptor mediates excitotoxicity-induced neural progenitor proliferation and neurogenesis. J Biol Chem. 2007;282:23892-8 pubmed
    ..cell engagement upon excitotoxicity induced by kainic acid administration and the putative involvement of the CB1 cannabinoid receptor in this process...
  29. Maresz K, Pryce G, Ponomarev E, Marsicano G, Croxford J, Shriver L, et al. Direct suppression of CNS autoimmune inflammation via the cannabinoid receptor CB1 on neurons and CB2 on autoreactive T cells. Nat Med. 2007;13:492-7 pubmed
    ..Together, our results demonstrate that the cannabinoid system within the CNS plays a critical role in regulating autoimmune inflammation, with the CNS directly suppressing T-cell effector function via the CB(2) receptor. ..
  30. Mievis S, Blum D, Ledent C. Worsening of Huntington disease phenotype in CB1 receptor knockout mice. Neurobiol Dis. 2011;42:524-9 pubmed publisher
    ..In addition, whether specific modulation of CB1R is able to mitigate striatal neuron fate in HD remains currently controversial...
  31. Bellocchio L, Lafenetre P, Cannich A, Cota D, Puente N, Grandes P, et al. Bimodal control of stimulated food intake by the endocannabinoid system. Nat Neurosci. 2010;13:281-3 pubmed publisher
    ..Conversely, brain CB(1) receptors modulating excitatory transmission mediated the well-known orexigenic effects of cannabinoids. ..
  32. Fitzgerald M, Lupica C, Pickel V. Decreased parvalbumin immunoreactivity in the cortex and striatum of mice lacking the CB1 receptor. Synapse. 2011;65:827-31 pubmed publisher
    Cortical and striatal regions of the brain contain high levels of the cannabinoid-1 (CB1) receptor, the central neuronal mediator of activity-dependent synaptic plasticity evoked by endocannabinoids...
  33. Plendl W, Wotjak C. Dissociation of within- and between-session extinction of conditioned fear. J Neurosci. 2010;30:4990-8 pubmed publisher
    ..Together, our findings demonstrate that within-session extinction is neither sufficient nor essential for between-session extinction, thus calling for a reconsideration of current concepts underlying exposure-based therapies. ..
  34. Song D, Bandsma R, Xiao C, Xi L, Shao W, Jin T, et al. Acute cannabinoid receptor type 1 (CB1R) modulation influences insulin sensitivity by an effect outside the central nervous system in mice. Diabetologia. 2011;54:1181-9 pubmed publisher
    Modulation of central nervous system (CNS) and extra-CNS cannabinoid receptor type 1 (CB1R) affects metabolic conditions, independently of weight loss...
  35. Pernía Andrade A, Kato A, Witschi R, Nyilas R, Katona I, Freund T, et al. Spinal endocannabinoids and CB1 receptors mediate C-fiber-induced heterosynaptic pain sensitization. Science. 2009;325:760-4 pubmed publisher
    ..We found that endocannabinoids, produced upon strong nociceptive stimulation, activated type 1 cannabinoid (CB1) receptors on inhibitory dorsal horn neurons to reduce the synaptic release of gamma-aminobutyric acid and glycine ..
  36. Wu C, Zhu J, Wager Miller J, Wang S, O LEARY D, Monory K, et al. Requirement of cannabinoid CB(1) receptors in cortical pyramidal neurons for appropriate development of corticothalamic and thalamocortical projections. Eur J Neurosci. 2010;32:693-706 pubmed publisher
    ..These findings are important in understanding the long-term consequences of alterations in CB(1)R activity during development, a potential etiology for the mental health disorders linked to prenatal cannabis use. ..
  37. Puente N, Elezgarai I, Lafourcade M, Reguero L, Marsicano G, Georges F, et al. Localization and function of the cannabinoid CB1 receptor in the anterolateral bed nucleus of the stria terminalis. PLoS ONE. 2010;5:e8869 pubmed publisher
    ..of this study was to provide a detailed morphological characterization of the localization of the cannabinoid 1 (CB1) receptor a necessary step toward a better understanding of the physiological roles of the eCB system in this ..
  38. Jin K, Xie L, Kim S, Parmentier Batteur S, Sun Y, Mao X, et al. Defective adult neurogenesis in CB1 cannabinoid receptor knockout mice. Mol Pharmacol. 2004;66:204-8 pubmed
    Pharmacological studies suggest a role for CB1 cannabinoid receptors (CB1R) in regulating neurogenesis in the adult brain...
  39. Osei Hyiaman D, Liu J, Zhou L, Godlewski G, Harvey White J, Jeong W, et al. Hepatic CB1 receptor is required for development of diet-induced steatosis, dyslipidemia, and insulin and leptin resistance in mice. J Clin Invest. 2008;118:3160-9 pubmed publisher
    ..implicated in the development of these associated phenotypes, because mice deficient for the cannabinoid receptor CB1 (CB1-/-) do not display these changes in association with diet-induced obesity...
  40. Compagnucci C, Di Siena S, Bustamante M, Di Giacomo D, Di Tommaso M, Maccarrone M, et al. Type-1 (CB1) cannabinoid receptor promotes neuronal differentiation and maturation of neural stem cells. PLoS ONE. 2013;8:e54271 pubmed publisher
    ..These results highlight the role of CB(1) in the regulation of NSC fate and suggest that its activation may represent a pro-neuronal differentiation signal. ..
  41. Deshmukh S, Onozuka K, Bender K, Bender V, Lutz B, Mackie K, et al. Postnatal development of cannabinoid receptor type 1 expression in rodent somatosensory cortex. Neuroscience. 2007;145:279-87 pubmed
    ..Cannabinoid receptor type 1 (CB1) is the dominant receptor in the CNS, and is present in many brain regions, including sensory cortex...
  42. Takahashi K, Castillo P. The CB1 cannabinoid receptor mediates glutamatergic synaptic suppression in the hippocampus. Neuroscience. 2006;139:795-802 pubmed
    ..Of the two cloned cannabinoid receptors, cannabinoid receptor 1 (CB1) is widely distributed in the CNS and accounts for most of the neurological effects of cannabinoids, ..
  43. Sales Carbonell C, Rueda Orozco P, Soria Gomez E, Buzsaki G, Marsicano G, Robbe D. Striatal GABAergic and cortical glutamatergic neurons mediate contrasting effects of cannabinoids on cortical network synchrony. Proc Natl Acad Sci U S A. 2013;110:719-24 pubmed publisher
    Activation of type 1 cannabinoid receptors (CB1R) decreases GABA and glutamate release in cortical and subcortical regions, with complex outcomes on cortical network activity...
  44. Massa F, Marsicano G, Hermann H, Cannich A, Monory K, Cravatt B, et al. The endogenous cannabinoid system protects against colonic inflammation. J Clin Invest. 2004;113:1202-9 pubmed
    ..Here, we show that cannabinoid receptors type 1 (CB1) mediate intrinsic protective signals that counteract proinflammatory responses...
  45. Straiker A, MIN K, Mackie K. Fmr1 deletion enhances and ultimately desensitizes CB(1) signaling in autaptic hippocampal neurons. Neurobiol Dis. 2013;56:1-5 pubmed publisher
    ..Furthermore, as neuronal cultures mature, CB1-receptor signaling strongly desensitizes...
  46. Pacher P, Kunos G. Modulating the endocannabinoid system in human health and disease--successes and failures. FEBS J. 2013;280:1918-43 pubmed publisher
    The discovery of the endocannabinoid system, comprising the G-protein coupled cannabinoid 1 and 2 receptors (CB1/2), their endogenous lipid ligands or endocannabinoids, and synthetic and metabolizing enzymes, has triggered an avalanche ..
  47. Grueter B, Gosnell H, Olsen C, Schramm Sapyta N, Nekrasova T, Landreth G, et al. Extracellular-signal regulated kinase 1-dependent metabotropic glutamate receptor 5-induced long-term depression in the bed nucleus of the stria terminalis is disrupted by cocaine administration. J Neurosci. 2006;26:3210-9 pubmed
  48. Sim Selley L, Schechter N, Rorrer W, Dalton G, Hernandez J, Martin B, et al. Prolonged recovery rate of CB1 receptor adaptation after cessation of long-term cannabinoid administration. Mol Pharmacol. 2006;70:986-96 pubmed
    Long-term cannabinoid administration produces region-dependent CB1 receptor desensitization and down-regulation...
  49. Tam J, Ofek O, Fride E, Ledent C, Gabet Y, Muller R, et al. Involvement of neuronal cannabinoid receptor CB1 in regulation of bone mass and bone remodeling. Mol Pharmacol. 2006;70:786-92 pubmed
    The CB1 cannabinoid receptor has been implicated in the regulation of bone remodeling and bone mass. A high bone mass (HBM) phenotype was reported in CB1-null mice generated on a CD1 background (CD1(CB1-/-) mice)...
  50. Liu J, Zhou L, Xiong K, Godlewski G, Mukhopadhyay B, Tam J, et al. Hepatic cannabinoid receptor-1 mediates diet-induced insulin resistance via inhibition of insulin signaling and clearance in mice. Gastroenterology. 2012;142:1218-1228.e1 pubmed publisher
    ..Endocannabinoids contribute to diet-induced insulin resistance in mice via hepatic CB(1)-mediated inhibition of insulin signaling and clearance. ..
  51. Agarwal N, Pacher P, Tegeder I, Amaya F, Constantin C, Brenner G, et al. Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptors. Nat Neurosci. 2007;10:870-9 pubmed
    ..We deleted the type 1 cannabinoid receptor (CB1) specifically in nociceptive neurons localized in the peripheral nervous system of mice, preserving its expression ..
  52. Albayram O, Alferink J, Pitsch J, Piyanova A, Neitzert K, Poppensieker K, et al. Role of CB1 cannabinoid receptors on GABAergic neurons in brain aging. Proc Natl Acad Sci U S A. 2011;108:11256-61 pubmed publisher
    ..Mice lacking the Cnr1 gene (Cnr1(-/-)), which encodes the cannabinoid receptor 1 (CB1), showed an accelerated age-dependent deficit in spatial learning accompanied by a loss of principal ..
  53. Lafenetre P, Chaouloff F, Marsicano G. Bidirectional regulation of novelty-induced behavioral inhibition by the endocannabinoid system. Neuropharmacology. 2009;57:715-21 pubmed publisher
    ..These data show a tightly regulated influence of the ECS on impulsive behaviors and suggest the involvement of endocannabinoid signaling in the pathophysiological modulation of ADHD and related disorders. ..
  54. Hill M, McLaughlin R, Pan B, Fitzgerald M, Roberts C, Lee T, et al. Recruitment of prefrontal cortical endocannabinoid signaling by glucocorticoids contributes to termination of the stress response. J Neurosci. 2011;31:10506-15 pubmed publisher
    ..These data support a model in which endocannabinoid signaling links glucocorticoid receptor engagement to activation of corticolimbic relays that inhibit corticosterone secretion. ..
  55. Mathur B, Tanahira C, Tamamaki N, Lovinger D. Voltage drives diverse endocannabinoid signals to mediate striatal microcircuit-specific plasticity. Nat Neurosci. 2013;16:1275-83 pubmed publisher
    The dorsolateral striatum and cannabinoid type 1 receptor (CB1) signaling mediate habitual action learning, which is thought to require a balance of activity in the direct and indirect striatal output pathways...
  56. Garzón J, de la Torre Madrid E, Rodríguez Muñoz M, Vicente Sánchez A, Sánchez Blázquez P. Gz mediates the long-lasting desensitization of brain CB1 receptors and is essential for cross-tolerance with morphine. Mol Pain. 2009;5:11 pubmed publisher
    ..On the other hand, acute morphine administration produced tolerance that lasted only 3 days and did not affect the CB1R. We found that both neural mu-opioid receptors (MORs) and CB1Rs interact with the HINT1-RGSZ module, thereby ..
  57. Jiang B, Huang S, De Pasquale R, Millman D, Song L, Lee H, et al. The maturation of GABAergic transmission in visual cortex requires endocannabinoid-mediated LTD of inhibitory inputs during a critical period. Neuron. 2010;66:248-59 pubmed publisher
    ..cannabinoid receptors as it is mimicked by administration of CB1 agonists, blocked by antagonists, and is absent in CB1R KO mice...
  58. Han K, Lim S, Ryu J, Lee C, Kim Y, Kang J, et al. CB1 and CB2 cannabinoid receptors differentially regulate the production of reactive oxygen species by macrophages. Cardiovasc Res. 2009;84:378-86 pubmed publisher
    We investigated the mechanism by which cannabinoid receptors-1 (CB1) and -2 (CB2) modulate inflammatory activities of macrophages...
  59. Kim K, Jo Y, Zhao L, Stallings N, Chua S, Parker K. Steroidogenic factor 1 regulates expression of the cannabinoid receptor 1 in the ventromedial hypothalamic nucleus. Mol Endocrinol. 2008;22:1950-61 pubmed publisher
    ..Here, we demonstrate that SF-1 colocalizes in VMH neurons with the cannabinoid receptor 1 (CB1R) and that a specific CB1R agonist modulates electrical activity of SF-1 neurons in hypothalamic ..
  60. Tam J, Trembovler V, Di Marzo V, Petrosino S, Leo G, Alexandrovich A, et al. The cannabinoid CB1 receptor regulates bone formation by modulating adrenergic signaling. FASEB J. 2008;22:285-94 pubmed
    We have recently reported that in bone the cannabinoid CB1 receptor is present in sympathetic terminals...
  61. Haring M, Marsicano G, Lutz B, Monory K. Identification of the cannabinoid receptor type 1 in serotonergic cells of raphe nuclei in mice. Neuroscience. 2007;146:1212-9 pubmed
    ..the ECS and the serotonergic system, there are no results showing clear evidence for type 1 cannabinoid receptor (CB1) location on serotonergic neurons...
  62. Kamprath K, Marsicano G, Tang J, Monory K, Bisogno T, Di Marzo V, et al. Cannabinoid CB1 receptor mediates fear extinction via habituation-like processes. J Neurosci. 2006;26:6677-86 pubmed
    ..Here, we demonstrate that the cannabinoid CB1 receptor, which is crucially involved in fear extinction, is dispensable for associative safety learning...
  63. Idris A, van t Hof R, Greig I, Ridge S, Baker D, Ross R, et al. Regulation of bone mass, bone loss and osteoclast activity by cannabinoid receptors. Nat Med. 2005;11:774-9 pubmed
    ..Here we show that mice with inactivation of cannabinoid type 1 (CB1) receptors have increased bone mass and are protected from ovariectomy-induced bone loss...
  64. Bilkei Gorzo A, Racz I, Valverde O, Otto M, Michel K, Sastre M, et al. Early age-related cognitive impairment in mice lacking cannabinoid CB1 receptors. Proc Natl Acad Sci U S A. 2005;102:15670-5 pubmed
    ..We demonstrate here that young mice (6-7 weeks) with a genetic deletion of the cannabinoid CB1 receptor performed as well as WT mice, or often better, in a number of learning and memory paradigms, including ..
  65. Urigüen L, Berrendero F, Ledent C, Maldonado R, Manzanares J. Kappa- and delta-opioid receptor functional activities are increased in the caudate putamen of cannabinoid CB1 receptor knockout mice. Eur J Neurosci. 2005;22:2106-10 pubmed
    ..functional activity and density of micro-, kappa- and delta-opioid receptors in both brain regions of cannabinoid CB1 receptor knockout mice. Functional activity was estimated by measuring agonist-stimulated [35S]GTPgammaS binding...
  66. Massa F, Mancini G, Schmidt H, Steindel F, Mackie K, Angioni C, et al. Alterations in the hippocampal endocannabinoid system in diet-induced obese mice. J Neurosci. 2010;30:6273-81 pubmed publisher
    ..Our results show that DIO-induced changes in the eCB system affect not only tissues directly involved in the metabolic regulation but also brain regions mediating hedonic aspects of eating and influencing cognitive processes. ..
  67. El Remessy A, Rajesh M, Mukhopadhyay P, Horvath B, Patel V, Al Gayyar M, et al. Cannabinoid 1 receptor activation contributes to vascular inflammation and cell death in a mouse model of diabetic retinopathy and a human retinal cell line. Diabetologia. 2011;54:1567-78 pubmed publisher
    ..Conversely, CB(1) receptor inhibition may be beneficial in the treatment of this devastating complication of diabetes. ..
  68. Schicho R, Bashashati M, Bawa M, McHugh D, Saur D, Hu H, et al. The atypical cannabinoid O-1602 protects against experimental colitis and inhibits neutrophil recruitment. Inflamm Bowel Dis. 2011;17:1651-64 pubmed publisher
    ..The protective effect was still present in cannabinoid receptor 1 (CB?) and 2 (CB?) double knockout mice and mice lacking the GPR55 gene...
  69. Berghuis P, Rajnicek A, Morozov Y, Ross R, Mulder J, Urbán G, et al. Hardwiring the brain: endocannabinoids shape neuronal connectivity. Science. 2007;316:1212-6 pubmed
  70. Galarreta M, Erdelyi F, Szabo G, Hestrin S. Electrical coupling among irregular-spiking GABAergic interneurons expressing cannabinoid receptors. J Neurosci. 2004;24:9770-8 pubmed
    Anatomical studies have shown that the G-protein-coupled cannabinoid receptor-1 (CB1) is selectively expressed in a subset of GABAergic interneurons...
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    ..OM-induced neuronal stimulation is reported to be reduced by cannabinoid agonists, and cannabinoid receptor 1 (CB1R)-/- mice have exacerbated experimental colitis...
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    The CB1 cannabinoid receptor, the main molecular target of endocannabinoids and cannabis active components, is the most abundant G protein-coupled receptor in the mammalian brain...
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    Endocannabinoids exert an important neuromodulatory role via presynaptic cannabinoid CB1 receptors and may also participate in the control of neural cell death and survival...
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    ..of the synapse, the axon terminals forming these excitatory contacts were found to be equipped with presynaptic CB1 cannabinoid receptors...
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    ..Here, we report that the type 1 cannabinoid receptor (CB1) regulates this process...