caveolin 1


Gene Symbol: caveolin 1
Description: caveolin 1, caveolae protein
Alias: Cav, Cav-1, caveolin-1, caveolin, caveolae protein 1, caveolin, caveolae protein, 22 kDa
Species: mouse
Products:     caveolin 1

Top Publications

  1. Lin M, Yu J, Murata T, Sessa W. Caveolin-1-deficient mice have increased tumor microvascular permeability, angiogenesis, and growth. Cancer Res. 2007;67:2849-56 pubmed
    Caveolin-1 (Cav-1) is a major structural protein that is essential to the formation of the organelle, caveolae. Cav-1 knockout (KO) mice were observed to be completely devoid of caveolae yet they exhibit a hyperpermeable vasculature...
  2. Matthews L, Taggart M, Westwood M. Modulation of caveolin-1 expression can affect signalling through the phosphatidylinositol 3-kinase/Akt pathway and cellular proliferation in response to insulin-like growth factor I. Endocrinology. 2008;149:5199-208 pubmed publisher
    ..These data posit caveolin-1 as a component of the IGF/PI-3K/Akt signalling modulus regulating cellular proliferation with implications for diseases, including cancers, which have altered caveolin expression. ..
  3. Zhang M, Lin L, Lee S, Mo L, Cao J, Ifedigbo E, et al. Deletion of caveolin-1 protects hyperoxia-induced apoptosis via survivin-mediated pathways. Am J Physiol Lung Cell Mol Physiol. 2009;297:L945-53 pubmed publisher
    ..Caveolae are omega-shaped invaginations of the plasma membrane. Caveolin-1 (cav-1), a 22-kDa transmembrane scaffolding protein, is the principal structural component of caveolae...
  4. Buitrago C, Boland R. Caveolae and caveolin-1 are implicated in 1alpha,25(OH)2-vitamin D3-dependent modulation of Src, MAPK cascades and VDR localization in skeletal muscle cells. J Steroid Biochem Mol Biol. 2010;121:169-75 pubmed publisher
    ..In this work, we investigated the role of caveolae and caveolin-1 (cav-1) in 1alpha,25(OH)2D3-stimulation of c-Src and MAPKs...
  5. Valasek M, Weng J, Shaul P, Anderson R, Repa J. Caveolin-1 is not required for murine intestinal cholesterol transport. J Biol Chem. 2005;280:28103-9 pubmed
    ..These results demonstrate that CAV1 is not required for cholesterol absorption or ezetimibe sensitivity in the mouse...
  6. Lobos González L, Aguilar L, Diaz J, Diaz N, Urra H, Torres V, et al. E-cadherin determines Caveolin-1 tumor suppression or metastasis enhancing function in melanoma cells. Pigment Cell Melanoma Res. 2013;26:555-70 pubmed publisher
    ..We find that overexpression of CAV1 in B16F10 (cav-1) cells reduces subcutaneous tumor formation, but enhances metastasis relative to control cells...
  7. Mirza M, Yuan J, Gao X, Garrean S, Brovkovych V, Malik A, et al. Caveolin-1 deficiency dampens Toll-like receptor 4 signaling through eNOS activation. Am J Pathol. 2010;176:2344-51 pubmed publisher
  8. Li Y, Lau W, So K, Tong Y, Shen J. Caveolin-1 promote astroglial differentiation of neural stem/progenitor cells through modulating Notch1/NICD and Hes1 expressions. Biochem Biophys Res Commun. 2011;407:517-24 pubmed publisher
    ..Taken together, these results provide strong evidence that caveolin-1 can promote astroglial differentiation of NPCs through modulating Notch1/NICD and Hes1 expressions. ..
  9. Chang S, Feng D, Nagy J, Sciuto T, Dvorak A, Dvorak H. Vascular permeability and pathological angiogenesis in caveolin-1-null mice. Am J Pathol. 2009;175:1768-76 pubmed publisher be the transcellular pathway by which plasma proteins cross normal capillary endothelium, but, unexpectedly, cav-1(-/-) mice, which lack caveolae, have increased permeability to plasma albumin...

More Information


  1. Yang G, Timme T, Naruishi K, Fujita T, Fattah E, Cao G, et al. Mice with cav-1 gene disruption have benign stromal lesions and compromised epithelial differentiation. Exp Mol Pathol. 2008;84:131-40 pubmed publisher
    Caveolin-1 (cav-1) is a major structural protein of caveolae, small invaginations of the plasma membrane that integrate and regulate signaling pathways involved in cell growth and differentiation...
  2. Norambuena A, Schwartz M. Effects of integrin-mediated cell adhesion on plasma membrane lipid raft components and signaling. Mol Biol Cell. 2011;22:3456-64 pubmed publisher
    ..These data define the effects of that integrin-mediated adhesion on the localization and behavior of a variety of lipid raft components and reveal the mechanism of the previously described elevation of cAMP after cell detachment. ..
  3. Fernandez M, Albor C, Ingelmo Torres M, Nixon S, Ferguson C, Kurzchalia T, et al. Caveolin-1 is essential for liver regeneration. Science. 2006;313:1628-32 pubmed
    ..Thus, caveolin-1 plays a crucial role in the mechanisms that coordinate lipid metabolism with the proliferative response occurring in the liver after cellular injury. ..
  4. Fernandez Hernando C, Yu J, Davalos A, Prendergast J, Sessa W. Endothelial-specific overexpression of caveolin-1 accelerates atherosclerosis in apolipoprotein E-deficient mice. Am J Pathol. 2010;177:998-1003 pubmed publisher
    Caveolin-1 (Cav-1) is the major structural protein essential to the formation of the caveolae in endothelial cells...
  5. Head B, Peart J, Panneerselvam M, Yokoyama T, Pearn M, Niesman I, et al. Loss of caveolin-1 accelerates neurodegeneration and aging. PLoS ONE. 2010;5:e15697 pubmed publisher
    ..Caveolin-1 (Cav-1), a cholesterol binding protein organizes synaptic signaling components within MLR...
  6. Odajima N, Betsuyaku T, Nasuhara Y, Nishimura M. Loss of caveolin-1 in bronchiolization in lung fibrosis. J Histochem Cytochem. 2007;55:899-909 pubmed
    ..These data suggested that loss of caveolin-1 is associated with abnormal re-epithelialization in lung fibrosis. ..
  7. Lajoie P, Kojic L, Nim S, Li L, Dennis J, Nabi I. Caveolin-1 regulation of dynamin-dependent, raft-mediated endocytosis of cholera toxin-B sub-unit occurs independently of caveolae. J Cell Mol Med. 2009;13:3218-25 pubmed publisher
    ..These results suggest that Cav1 regulates raft-dependent internalization of CT-b indirectly via a mechanism that requires the Cav1 scaffolding domain and the formation of oligomerized Cav1 microdomains but not caveolae. ..
  8. Le Saux O, Teeters K, Miyasato S, Choi J, Nakamatsu G, Richardson J, et al. The role of caveolin-1 in pulmonary matrix remodeling and mechanical properties. Am J Physiol Lung Cell Mol Physiol. 2008;295:L1007-17 pubmed publisher
  9. Chidlow J, Greer J, Anthoni C, Bernatchez P, Fernandez Hernando C, Fernadez Hernando C, et al. Endothelial caveolin-1 regulates pathologic angiogenesis in a mouse model of colitis. Gastroenterology. 2009;136:575-84.e2 pubmed publisher
    ..Caveolin-1 (Cav-1), the major structural protein of caveolae in endothelial cells, is involved in the regulation of angiogenesis, ..
  10. Le Saux C, Teeters K, Miyasato S, Hoffmann P, Bollt O, Douet V, et al. Down-regulation of caveolin-1, an inhibitor of transforming growth factor-beta signaling, in acute allergen-induced airway remodeling. J Biol Chem. 2008;283:5760-8 pubmed
    ..This study demonstrates a previously unknown modulation of TGF-beta signaling by IL-4, via cav1, suggesting novel therapeutic targets for controlling the effects of TGF-beta and thereby ameliorating pathological airway remodeling. ..
  11. Stoeber M, Stoeck I, Hänni C, Bleck C, Balistreri G, Helenius A. Oligomers of the ATPase EHD2 confine caveolae to the plasma membrane through association with actin. EMBO J. 2012;31:2350-64 pubmed publisher
    ..Thus, EHD2 likely plays a key role in adjusting the balance between PM functions of stationary caveolae and the role of caveolae as vesicular carriers. ..
  12. Nethe M, Anthony E, Fernandez Borja M, Dee R, Geerts D, Hensbergen P, et al. Focal-adhesion targeting links caveolin-1 to a Rac1-degradation pathway. J Cell Sci. 2010;123:1948-58 pubmed publisher
    ..These data extend the canonical model of Rac1 inactivation and uncover Cav1-regulated polyubiquitylation as an additional mechanism to control Rac1 signalling. ..
  13. Senju Y, Itoh Y, Takano K, Hamada S, Suetsugu S. Essential role of PACSIN2/syndapin-II in caveolae membrane sculpting. J Cell Sci. 2011;124:2032-40 pubmed publisher
    ..These results indicate that PACSIN2 mediates membrane sculpting by caveolin-1 in caveola morphology and recruits dynamin-2 for caveola fission. ..
  14. Fernández Rojo M, Restall C, Ferguson C, Martel N, Martin S, Bosch M, et al. Caveolin-1 orchestrates the balance between glucose and lipid-dependent energy metabolism: implications for liver regeneration. Hepatology. 2012;55:1574-84 pubmed publisher
    ..Our data demonstrate that lack of CAV1 alters hepatocyte energy metabolism homeostasis under physiological and pathological conditions. ..
  15. Peterson T, d Uscio L, Cao S, Wang X, Katusic Z. Guanosine triphosphate cyclohydrolase I expression and enzymatic activity are present in caveolae of endothelial cells. Hypertension. 2009;53:189-95 pubmed publisher
    ..In addition, our findings provide new insights into the regulation of GTPCH I activity by the caveolar coat protein, caveolin-1. ..
  16. Shivshankar P, Brampton C, Miyasato S, Kasper M, Thannickal V, Le Saux C. Caveolin-1 deficiency protects from pulmonary fibrosis by modulating epithelial cell senescence in mice. Am J Respir Cell Mol Biol. 2012;47:28-36 pubmed publisher
    Idiopathic pulmonary fibrosis is associated with a decreased expression of caveolin-1 (cav-1), yet its role remains unclear...
  17. Yamaguchi Y, Yasuoka H, Stolz D, Feghali Bostwick C. Decreased caveolin-1 levels contribute to fibrosis and deposition of extracellular IGFBP-5. J Cell Mol Med. 2011;15:957-69 pubmed publisher
    ..Since Caveolin-1 (Cav-1) has been implicated to play a role in membrane trafficking and signal transduction in tissue fibrosis, we ..
  18. Goetz J, Joshi B, Lajoie P, Strugnell S, Scudamore T, Kojic L, et al. Concerted regulation of focal adhesion dynamics by galectin-3 and tyrosine-phosphorylated caveolin-1. J Cell Biol. 2008;180:1261-75 pubmed publisher
    ..Thus, transmembrane crosstalk between the galectin lattice and pY14Cav1 promotes FA turnover by stabilizing FAK within FAs defining previously unknown, interdependent roles for galectin-3 and pY14Cav1 in tumor cell migration. ..
  19. Grände G, Rippe C, Rippe A, Rahman A, Swärd K, Rippe B. Unaltered size selectivity of the glomerular filtration barrier in caveolin-1 knockout mice. Am J Physiol Renal Physiol. 2009;297:F257-62 pubmed publisher
  20. Le Lay S, Briand N, Blouin C, Chateau D, Prado C, Lasnier F, et al. The lipoatrophic caveolin-1 deficient mouse model reveals autophagy in mature adipocytes. Autophagy. 2010;6:754-63 pubmed
    ..This is the first report of a pathological situation with autophagy as an adaptative response to adipocyte failure. ..
  21. Mattsson C, Andersson E, Nedergaard J. Differential involvement of caveolin-1 in brown adipocyte signaling: impaired beta3-adrenergic, but unaffected LPA, PDGF and EGF receptor signaling. Biochim Biophys Acta. 2010;1803:983-9 pubmed publisher
    ..Thus, in brown adipocytes, Cav1 is apparently required for an intact response to adenylyl cyclase-linked agonists/activators, whereas other signaling pathways examined function without Cav1. ..
  22. Head B, Patel H, Tsutsumi Y, Hu Y, Mejia T, Mora R, et al. Caveolin-1 expression is essential for N-methyl-D-aspartate receptor-mediated Src and extracellular signal-regulated kinase 1/2 activation and protection of primary neurons from ischemic cell death. FASEB J. 2008;22:828-40 pubmed
  23. Fernandez Rojo M, Gongora M, Fitzsimmons R, Martel N, Martin S, Nixon S, et al. Caveolin-1 is necessary for hepatic oxidative lipid metabolism: evidence for crosstalk between caveolin-1 and bile acid signaling. Cell Rep. 2013;4:238-47 pubmed publisher
    ..These results demonstrate the significance of CAV1 in (1) hepatic lipid homeostasis and (2) nuclear hormone receptor (PPAR?, FXR?, and SHP) and bile acid signaling. ..
  24. Goetz J, Minguet S, Navarro Lérida I, Lazcano J, Samaniego R, Calvo E, et al. Biomechanical remodeling of the microenvironment by stromal caveolin-1 favors tumor invasion and metastasis. Cell. 2011;146:148-63 pubmed publisher
    ..Thus, Cav1 modulates tissue responses through force-dependent architectural regulation of the microenvironment. ..
  25. Place A, Chen Z, Bakhshi F, Liu G, O Bryan J, Minshall R. Cooperative role of caveolin-1 and C-terminal Src kinase binding protein in C-terminal Src kinase-mediated negative regulation of c-Src. Mol Pharmacol. 2011;80:665-72 pubmed publisher, we assessed the cooperative roles of C-terminal Src kinase (Csk) binding protein (Cbp) and Caveolin-1 (Cav-1) in the mechanism of Src family tyrosine kinase (SFK) inhibition by Csk...
  26. Fu Y, Moore X, Lee M, Fernandez Rojo M, Parat M, Parton R, et al. Caveolin-1 plays a critical role in the differentiation of monocytes into macrophages. Arterioscler Thromb Vasc Biol. 2012;32:e117-25 pubmed publisher
    ..Caveolin-1 promotes monocyte to macrophage differentiation through the regulation of EGR-1 transcriptional activity, suggesting that phagocytic caveolin-1 may be critical for atherogenesis. ..
  27. Hill M, Bastiani M, Luetterforst R, Kirkham M, Kirkham A, Nixon S, et al. PTRF-Cavin, a conserved cytoplasmic protein required for caveola formation and function. Cell. 2008;132:113-24 pubmed publisher
    ..We used comparative proteomics to identify PTRF (also called Cav-p60, Cavin) as a putative caveolar coat protein...
  28. Rosengren B, Rippe A, Rippe C, Venturoli D, Swärd K, Rippe B. Transvascular protein transport in mice lacking endothelial caveolae. Am J Physiol Heart Circ Physiol. 2006;291:H1371-7 pubmed
    ..Studies on mice lacking endothelial caveolae, caveolin-1 knockout (Cav-1-KO) mice, indicate increased macromolecular transport rates...
  29. Murata T, Lin M, Huang Y, Yu J, Bauer P, Giordano F, et al. Reexpression of caveolin-1 in endothelium rescues the vascular, cardiac, and pulmonary defects in global caveolin-1 knockout mice. J Exp Med. 2007;204:2373-82 pubmed
    Caveolin-1 (Cav-1) is the principal structural component of caveolae organelles in smooth muscle cells, adipocytes, fibroblasts, epithelial cells, and endothelial cells (ECs)...
  30. Wang X, Kim H, Nakahira K, Ryter S, Choi A. The heme oxygenase-1/carbon monoxide pathway suppresses TLR4 signaling by regulating the interaction of TLR4 with caveolin-1. J Immunol. 2009;182:3809-18 pubmed publisher
    Caveolin-1 (cav-1), the principle structural protein of plasmalemmal caveolae, regulates inflammatory signaling processes originating at the membrane...
  31. González Muñoz E, Lopez Iglesias C, Calvo M, Palacin M, Zorzano A, Camps M. Caveolin-1 loss of function accelerates glucose transporter 4 and insulin receptor degradation in 3T3-L1 adipocytes. Endocrinology. 2009;150:3493-502 pubmed publisher
    ..We propose that caveolin-1/caveolae control insulin action in adipose cells...
  32. Pojoga L, Romero J, Yao T, Loutraris P, Ricchiuti V, Coutinho P, et al. Caveolin-1 ablation reduces the adverse cardiovascular effects of N-omega-nitro-L-arginine methyl ester and angiotensin II. Endocrinology. 2010;151:1236-46 pubmed publisher
    ..In vascular tissue (but not ventricular myocardium), caveolin-1 (cav-1) is the main component of caveolae; cav-1 modulates enzymes and receptors, such as the endothelial nitric oxide ..
  33. Niesman I, Zemke N, Fridolfsson H, Haushalter K, Levy K, Grove A, et al. Caveolin isoform switching as a molecular, structural, and metabolic regulator of microglia. Mol Cell Neurosci. 2013;56:283-97 pubmed publisher
    ..We detected mRNA and protein for both Cav-1 and Cav-3...
  34. Jasmin J, Yang M, Iacovitti L, Lisanti M. Genetic ablation of caveolin-1 increases neural stem cell proliferation in the subventricular zone (SVZ) of the adult mouse brain. Cell Cycle. 2009;8:3978-83 pubmed
    ..For instance, ablation of the caveolin-1 (Cav-1) gene in mice markedly increases the proliferation of intestinal and mammary stem cells...
  35. Hill M, Daud N, Aung C, Loo D, Martin S, Murphy S, et al. Co-regulation of cell polarization and migration by caveolar proteins PTRF/Cavin-1 and caveolin-1. PLoS ONE. 2012;7:e43041 pubmed publisher
    ..By selectively manipulating PTRF/cavin-1 and caveolin-1 expression (and therefore caveola formation) in multiple cell systems, we unveil caveola-independent functions for both proteins in cell migration. ..
  36. Jasmin J, Rengo G, Lymperopoulos A, Gupta R, Eaton G, Quann K, et al. Caveolin-1 deficiency exacerbates cardiac dysfunction and reduces survival in mice with myocardial infarction. Am J Physiol Heart Circ Physiol. 2011;300:H1274-81 pubmed publisher
    Caveolin (Cav)-1 has been involved in the pathogenesis of ischemic injuries. For instance, modulations of Cav-1 expression have been reported in animal models of myocardial infarction and cerebral ischemia-reperfusion...
  37. Pojoga L, Underwood P, Goodarzi M, Williams J, Adler G, Jeunemaitre X, et al. Variants of the caveolin-1 gene: a translational investigation linking insulin resistance and hypertension. J Clin Endocrinol Metab. 2011;96:E1288-92 pubmed publisher
    ..Variations in the CAV1 gene are associated with IR and hypertension. CAV1 gene polymorphisms may be a biomarker for IR and hypertension, enabling earlier detection and improved treatment strategies. ..
  38. Asterholm I, Mundy D, Weng J, Anderson R, Scherer P. Altered mitochondrial function and metabolic inflexibility associated with loss of caveolin-1. Cell Metab. 2012;15:171-85 pubmed publisher
    ..This mouse model highlights the central contributions of adipose tissue for system-wide preservation of metabolic flexibility. ..
  39. Allen J, Yu J, Dave R, Bhatnagar A, Roth B, Rasenick M. Caveolin-1 and lipid microdomains regulate Gs trafficking and attenuate Gs/adenylyl cyclase signaling. Mol Pharmacol. 2009;76:1082-93 pubmed publisher
    ..It is suggested that lipid rafts/caveolae are sites that remove Galpha(s) from membrane signaling cascades and caveolins might dampen globally Galpha(s)/adenylyl cyclase/cAMP signaling. ..
  40. Le Lay S, Kurzchalia T. Getting rid of caveolins: phenotypes of caveolin-deficient animals. Biochim Biophys Acta. 2005;1746:322-33 pubmed
    ..The generation of mice deficient in the various caveolin genes (cav-1, cav-2 and cav-3) has provided physiological models to unravel the role of caveolins or caveolae at the whole ..
  41. Trushina E, Du Charme J, Parisi J, McMurray C. Neurological abnormalities in caveolin-1 knock out mice. Behav Brain Res. 2006;172:24-32 pubmed
    ..In the brain, cav-1 is highly expressed in neurons and glia, but its function in those cell types is unclear...
  42. Wunderlich C, Schober K, Schmeisser A, Heerwagen C, Tausche A, Steinbronn N, et al. The adverse cardiopulmonary phenotype of caveolin-1 deficient mice is mediated by a dysfunctional endothelium. J Mol Cell Cardiol. 2008;44:938-47 pubmed publisher
    Recently generated caveolin-1 deficient mice (cav-1(-/-)) display several physiological alterations such as severe heart failure and lung fibrosis...
  43. Wunderlich C, Schober K, Kasper M, Heerwagen C, Marquetant R, Ebner B, et al. Nitric oxide synthases are crucially involved in the development of the severe cardiomyopathy of caveolin-1 knockout mice. Biochem Biophys Res Commun. 2008;377:769-74 pubmed publisher
    Targeted ablation of caveolin-1 (cav-1) results in a severe cardiomyopathy. How the loss of cav-1 mediates these abnormalities is currently under investigation...
  44. Volonte D, Kahkonen B, Shapiro S, Di Y, Galbiati F. Caveolin-1 expression is required for the development of pulmonary emphysema through activation of the ATM-p53-p21 pathway. J Biol Chem. 2009;284:5462-6 pubmed publisher
  45. Zhao Y, Zhao Y, Mirza M, Huang J, Potula H, Vogel S, et al. Persistent eNOS activation secondary to caveolin-1 deficiency induces pulmonary hypertension in mice and humans through PKG nitration. J Clin Invest. 2009;119:2009-18 pubmed publisher
    ..Using mice with genetic deletions of caveolin 1 (Cav1) and eNOS (Nos3), we demonstrate here that chronic eNOS activation secondary to loss of caveolin-1 can ..
  46. Feng H, Guo L, Song Z, Gao H, Wang D, Fu W, et al. Caveolin-1 protects against sepsis by modulating inflammatory response, alleviating bacterial burden, and suppressing thymocyte apoptosis. J Biol Chem. 2010;285:25154-60 pubmed publisher
    ..Caveolin-1 exerts its protective function likely through its roles in modulating inflammatory response, alleviating bacterial burdens, and suppressing thymocyte apoptosis. ..
  47. Gioiosa L, Raggi C, Ricceri L, Jasmin J, Frank P, Capozza F, et al. Altered emotionality, spatial memory and cholinergic function in caveolin-1 knock-out mice. Behav Brain Res. 2008;188:255-62 pubmed
    Neurological phenotypes associated with loss of caveolin 1 (cav-1) (the defining structural protein in caveolar vesicles, which regulate signal transduction and cholesterol trafficking in cells) in mice have been reported recently...
  48. Medina F, Cohen A, de Almeida C, Nagajyothi F, Braunstein V, Teixeira M, et al. Immune dysfunction in caveolin-1 null mice following infection with Trypanosoma cruzi (Tulahuen strain). Microbes Infect. 2007;9:325-33 pubmed potentially important targets for pathogenic microorganisms; therefore, we investigated the role of caveolin-1 (Cav-1) in T. cruzi infection using Cav-1 null mice...
  49. Hoffmann C, Berking A, Agerer F, Buntru A, Neske F, Chhatwal G, et al. Caveolin limits membrane microdomain mobility and integrin-mediated uptake of fibronectin-binding pathogens. J Cell Sci. 2010;123:4280-91 pubmed publisher
    ..This process might not only limit host cell invasion by integrin-binding bacterial pathogens, but might also be physiologically relevant for integrin-mediated cell adhesion. ..
  50. Krieger M, Di Lorenzo A, Teutsch C, Kauser K, Sessa W. Telmisartan regresses left ventricular hypertrophy in caveolin-1-deficient mice. Lab Invest. 2010;90:1573-81 pubmed publisher well known; however, its role in a spontaneous model of hypertrophy in mice lacking the protein caveolin-1 (Cav-1 KO) has not been explored...
  51. Gadjeva M, Paradis Bleau C, Priebe G, Fichorova R, Pier G. Caveolin-1 modifies the immunity to Pseudomonas aeruginosa. J Immunol. 2010;184:296-302 pubmed publisher
    ..better compared with the wild-type controls in a model of chronic infection, indicting an important contribution of Cav-1 to innate host immunity to P...
  52. Shakirova Y, Bonnevier J, Albinsson S, Adner M, Rippe B, Broman J, et al. Increased Rho activation and PKC-mediated smooth muscle contractility in the absence of caveolin-1. Am J Physiol Cell Physiol. 2006;291:C1326-35 pubmed
    ..RhoA/Rho-kinase and protein kinase C (PKC)-mediated Ca(2+) sensitization depends on caveolae using caveolin (Cav)-1-deficient (KO) and wild-type (WT) mice...
  53. Frank P, Cheung M, Pavlides S, Llaverias G, Park D, Lisanti M. Caveolin-1 and regulation of cellular cholesterol homeostasis. Am J Physiol Heart Circ Physiol. 2006;291:H677-86 pubmed
    ..We have recently generated caveolin-1-deficient [Cav-1(-/-)] mice in which caveolae organelles are completely eliminated from all cell types, except cardiac and ..
  54. Xia H, Khalil W, Kahm J, Jessurun J, Kleidon J, Henke C. Pathologic caveolin-1 regulation of PTEN in idiopathic pulmonary fibrosis. Am J Pathol. 2010;176:2626-37 pubmed publisher
    ..This creates a membrane microenvironment depleted of inhibitory phosphatase activity, facilitating the aberrant activation PI3K/Akt and pathological proliferation. ..
  55. Le Lay S, Li Q, Proschogo N, Rodriguez M, Gunaratnam K, Cartland S, et al. Caveolin-1-dependent and -independent membrane domains. J Lipid Res. 2009;50:1609-20 pubmed publisher
    ..In contrast, the abundance of ordered domains in adherent cells is reduced in Cav1(-/-) compared with WT MEFs, suggesting that cell architecture is critical in maintaining Cav1-induced lipid rafts...
  56. Miyawaki Shimizu K, Predescu D, Shimizu J, Broman M, Predescu S, Malik A. siRNA-induced caveolin-1 knockdown in mice increases lung vascular permeability via the junctional pathway. Am J Physiol Lung Cell Mol Physiol. 2006;290:L405-13 pubmed
    ..Thus our results demonstrate the essential requirement of caveolin-1 in mediating the formation of caveolae in endothelial cells in vivo and in negatively regulating IEJ permeability. ..
  57. Watanabe M, Yang G, Cao G, Tahir S, Naruishi K, Tabata K, et al. Functional analysis of secreted caveolin-1 in mouse models of prostate cancer progression. Mol Cancer Res. 2009;7:1446-55 pubmed publisher
    Previously, we reported that caveolin-1 (cav-1) is overexpressed in metastatic prostate cancer and that virulent prostate cancer cells secrete biologically active cav-1...
  58. Wang X, Zhang Y, Kim H, Zhou Z, Feghali Bostwick C, Liu F, et al. Caveolin-1: a critical regulator of lung fibrosis in idiopathic pulmonary fibrosis. J Exp Med. 2006;203:2895-906 pubmed
    ..Caveolin-1 (cav-1), a principal component of caveolae, has been implicated in the regulation of numerous signaling pathways and ..
  59. Feher A, Rutkai I, Beleznai T, Ungvari Z, Csiszar A, Edes I, et al. Caveolin-1 limits the contribution of BK(Ca) channel to EDHF-mediated arteriolar dilation: implications in diet-induced obesity. Cardiovasc Res. 2010;87:732-9 pubmed publisher
    Caveolin-1 (Cav-1) interacts with large conductance Ca(2+)-activated potassium channels (BKCa) and likely exerts a negative regulatory effect on the channel activity...
  60. Morén B, Shah C, Howes M, Schieber N, McMahon H, Parton R, et al. EHD2 regulates caveolar dynamics via ATP-driven targeting and oligomerization. Mol Biol Cell. 2012;23:1316-29 pubmed publisher
    ..Thus, following the identification of caveolin and cavins, EHD2 constitutes a third structural component of caveolae involved in controlling the stability and turnover of this organelle. ..
  61. Volonte D, Liu Z, Musille P, Stoppani E, Wakabayashi N, Di Y, et al. Inhibition of nuclear factor-erythroid 2-related factor (Nrf2) by caveolin-1 promotes stress-induced premature senescence. Mol Biol Cell. 2013;24:1852-62 pubmed publisher
    ..Thus, by inhibiting Nrf2-mediated signaling, caveolin-1 links free radicals to the activation of the p53/senescence pathway. ..
  62. Jasmin J, Malhotra S, Singh Dhallu M, Mercier I, Rosenbaum D, Lisanti M. Caveolin-1 deficiency increases cerebral ischemic injury. Circ Res. 2007;100:721-9 pubmed
    Caveolins (Cav), the principal structural proteins of the caveolar domains, have been implicated in the pathogenesis of ischemic injury...
  63. Murata T, Lin M, Stan R, Bauer P, Yu J, Sessa W. Genetic evidence supporting caveolae microdomain regulation of calcium entry in endothelial cells. J Biol Chem. 2007;282:16631-43 pubmed
    ..Here, using mice deficient in caveolin-1 (Cav-1) and Cav-1 knock-out reconstituted with endothelium-specific Cav-1, we show that Cav-1 is essential for calcium ..
  64. Tahir S, Yang G, Goltsov A, Watanabe M, Tabata K, Addai J, et al. Tumor cell-secreted caveolin-1 has proangiogenic activities in prostate cancer. Cancer Res. 2008;68:731-9 pubmed publisher
    ..We showed in earlier studies that caveolin-1 (cav-1) is consistently and strongly overexpressed in metastatic prostate cancer and is secreted in a biologically ..
  65. Fernandez Hernando C, Yu J, Suarez Y, Rahner C, Davalos A, Lasunción M, et al. Genetic evidence supporting a critical role of endothelial caveolin-1 during the progression of atherosclerosis. Cell Metab. 2009;10:48-54 pubmed publisher
    ..Here, by using endothelial cell-specific transgenesis of the caveolin-1 (Cav-1) gene in mice, we show the critical role of Cav-1 in promoting atherogenesis...
  66. Balasubramanian N, Meier J, Scott D, Norambuena A, White M, Schwartz M. RalA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth signaling. Curr Biol. 2010;20:75-9 pubmed publisher
    ..They therefore define a mechanism by which RalA regulates anchorage dependence and provide a new link between integrin signaling and cancer. ..
  67. Roelandt T, Giddelo C, Heughebaert C, Denecker G, Hupe M, Crumrine D, et al. The "caveolae brake hypothesis" and the epidermal barrier. J Invest Dermatol. 2009;129:927-36 pubmed publisher
    ..dynamics and barrier recovery in methyl-beta-cyclodextrin (MbetaCD)-treated hairless mice and caveolin-1 knockouts (cav-1(-/-)). MbetaCD treatment impaired APM raft-like domain formation and barrier recovery...
  68. Blouin C, Le Lay S, Eberl A, Köfeler H, Guerrera I, Klein C, et al. Lipid droplet analysis in caveolin-deficient adipocytes: alterations in surface phospholipid composition and maturation defects. J Lipid Res. 2010;51:945-56 pubmed publisher
    ..Altogether, these data demonstrate that the lipid droplet-caveolin pool impacts on phospholipid and protein surface composition of lipid droplets and suggest a functional role on lipid droplet expandability. ..
  69. Briand N, Le Lay S, Sessa W, Ferre P, Dugail I. Distinct roles of endothelial and adipocyte caveolin-1 in macrophage infiltration and adipose tissue metabolic activity. Diabetes. 2011;60:448-53 pubmed publisher
  70. Maniatis N, Shinin V, Schraufnagel D, Okada S, Vogel S, Malik A, et al. Increased pulmonary vascular resistance and defective pulmonary artery filling in caveolin-1-/- mice. Am J Physiol Lung Cell Mol Physiol. 2008;294:L865-73 pubmed publisher
    ..The elevated basal plasma NO level in Cav1(-/-) mice compensates partly for the vascular structural abnormalities by promoting pulmonary vasodilation. ..
  71. Heimerl S, Liebisch G, Le Lay S, Böttcher A, Wiesner P, Lindtner S, et al. Caveolin-1 deficiency alters plasma lipid and lipoprotein profiles in mice. Biochem Biophys Res Commun. 2008;367:826-33 pubmed publisher the result of local accumulation of cholesterol, glycosphingolipids, and the structural protein caveolin-1 (Cav-1)...
  72. Burgermeister E, Friedrich T, Hitkova I, Regel I, Einwächter H, Zimmermann W, et al. The Ras inhibitors caveolin-1 and docking protein 1 activate peroxisome proliferator-activated receptor ? through spatial relocalization at helix 7 of its ligand-binding domain. Mol Cell Biol. 2011;31:3497-510 pubmed publisher
    ..These results suggest a novel mechanism of PPAR? regulation by which Ras/MAPK inhibitors act as scaffold proteins that sequester and sensitize PPAR? to ligands, limiting proliferation of gastric epithelial cells. ..
  73. Albinsson S, Shakirova Y, Rippe A, Baumgarten M, Rosengren B, Rippe C, et al. Arterial remodeling and plasma volume expansion in caveolin-1-deficient mice. Am J Physiol Regul Integr Comp Physiol. 2007;293:R1222-31 pubmed
    Caveolin-1 (Cav-1) is essential for the morphology of membrane caveolae and exerts a negative influence on a number of signaling systems, including nitric oxide (NO) production and activity of the MAP kinase cascade...
  74. Tse E, Ko F, Tung E, Chan L, Lee T, Ngan E, et al. Caveolin-1 overexpression is associated with hepatocellular carcinoma tumourigenesis and metastasis. J Pathol. 2012;226:645-53 pubmed publisher
    ..The definitive role of Cav1 in promoting HCC tumourigenesis was demonstrated, and we have shown for the first time in a mouse model that Cav1 promotes HCC metastasis. ..
  75. Kabayama K, Sato T, Saito K, Loberto N, Prinetti A, Sonnino S, et al. Dissociation of the insulin receptor and caveolin-1 complex by ganglioside GM3 in the state of insulin resistance. Proc Natl Acad Sci U S A. 2007;104:13678-83 pubmed
  76. Mattsson C, Csikasz R, Shabalina I, Nedergaard J, Cannon B. Caveolin-1-ablated mice survive in cold by nonshivering thermogenesis despite desensitized adrenergic responsiveness. Am J Physiol Endocrinol Metab. 2010;299:E374-83 pubmed publisher
  77. Uemura T, Stringer D, Blohm Mangone K, Gerner E. Polyamine transport is mediated by both endocytic and solute carrier transport mechanisms in the gastrointestinal tract. Am J Physiol Gastrointest Liver Physiol. 2010;299:G517-22 pubmed publisher
  78. Li J, Scherl A, Medina F, Frank P, Kitsis R, Tanowitz H, et al. Impaired phagocytosis in caveolin-1 deficient macrophages. Cell Cycle. 2005;4:1599-607 pubmed
    ..Caveolin-1 (Cav-1) constitutes the main structural protein of caveolae membranes...
  79. Park J, Han H. Caveolin-1 plays important role in EGF-induced migration and proliferation of mouse embryonic stem cells: involvement of PI3K/Akt and ERK. Am J Physiol Cell Physiol. 2009;297:C935-44 pubmed publisher
    ..In conclusion, these results demonstrated that EGF-induced DNA synthesis and cell migration are mediated by caveolin-1, which is activated by Src, FAK, PI3K/Akt, ERK, and MMP-2 signals in mouse ES cells. ..
  80. Wunderlich C, Schober K, Lange S, Drab M, Braun Dullaeus R, Kasper M, et al. Disruption of caveolin-1 leads to enhanced nitrosative stress and severe systolic and diastolic heart failure. Biochem Biophys Res Commun. 2006;340:702-8 pubmed
    ..findings we aimed to elucidate the cardiac phenotype of independently generated caveolin-1 knockout mice (cav-1(-/-)) and to unveil causative mechanisms...
  81. Yuan K, Huang C, Fox J, Gaid M, Weaver A, Li G, et al. Elevated inflammatory response in caveolin-1-deficient mice with Pseudomonas aeruginosa infection is mediated by STAT3 protein and nuclear factor kappaB (NF-kappaB). J Biol Chem. 2011;286:21814-25 pubmed publisher
    Caveolin-1 (Cav-1), an important composition protein within the flask-shaped membrane invaginations termed caveolae, may play a role in host defense against infections...
  82. Li Z, Wermuth P, Benn B, Lisanti M, Jimenez S. Caveolin-1 deficiency induces spontaneous endothelial-to-mesenchymal transition in murine pulmonary endothelial cells in vitro. Am J Pathol. 2013;182:325-31 pubmed publisher
    ..The findings suggest that CAV1 regulation of EndoMT may play a role in the development of fibroproliferative vasculopathies. ..
  83. Siddiqui M, Komarova Y, Vogel S, Gao X, Bonini M, Rajasingh J, et al. Caveolin-1-eNOS signaling promotes p190RhoGAP-A nitration and endothelial permeability. J Cell Biol. 2011;193:841-50 pubmed publisher
    ..The opening of AJs that is observed in caveolin-1(-/-) (Cav-1(-/-)) endothelium suggests that Cav-1 is necessary for AJ assembly or maintenance...
  84. Capozza F, Trimmer C, Castello Cros R, Katiyar S, Whitaker Menezes D, Follenzi A, et al. Genetic ablation of Cav1 differentially affects melanoma tumor growth and metastasis in mice: role of Cav1 in Shh heterotypic signaling and transendothelial migration. Cancer Res. 2012;72:2262-74 pubmed publisher
    ..Together, our findings show that Cav1 may regulate different mechanisms during primary melanoma tumor growth and metastatic dissemination. ..
  85. Lee S, Lee Y, Park S, Kim H, Han H. Caveolin-1 and integrin ?1 regulate embryonic stem cell proliferation via p38 MAPK and FAK in high glucose. J Cell Physiol. 2011;226:1850-9 pubmed publisher
    The involvement of caveolin-1 (Cav-1) and integrin ?1 (IN ?1) in regulation of embryonic stem (ES) cell growth by high glucose is by no means clear cut...
  86. Tourkina E, Richard M, Gooz P, Bonner M, Pannu J, Harley R, et al. Antifibrotic properties of caveolin-1 scaffolding domain in vitro and in vivo. Am J Physiol Lung Cell Mol Physiol. 2008;294:L843-61 pubmed publisher
    ..CSD peptide may be a prototype for novel treatments for human lung fibrosis that act, in part, by inhibiting the expression of ASMA and ECM proteins. ..
  87. Engel D, Beckers L, Wijnands E, Seijkens T, Lievens D, Drechsler M, et al. Caveolin-1 deficiency decreases atherosclerosis by hampering leukocyte influx into the arterial wall and generating a regulatory T-cell response. FASEB J. 2011;25:3838-48 pubmed publisher
    ..Our study reveals that nonhematopoietic caveolin-1 determines plaque size, whereas hematopoietic caveolin-1 regulates lymphoid immune-modulation. However, both are required for phenotypic modulation of plaques. ..