Catsper1

Summary

Gene Symbol: Catsper1
Description: cation channel, sperm associated 1
Alias: Catsper, KSper, cation channel sperm-associated protein 1, cation channel of sperm 1, sperm calcium channel 1, sperm ion channel, sperm protein CATSPER1
Species: mouse
Products:     Catsper1

Top Publications

  1. Xia J, Ren D. Egg coat proteins activate calcium entry into mouse sperm via CATSPER channels. Biol Reprod. 2009;80:1092-8 pubmed publisher
    ..Instead, CATSPER channels localized in the distal portion of sperm (the principal piece) are required for the ZP-induced [Ca(2+)](..
  2. Navarro B, Miki K, Clapham D. ATP-activated P2X2 current in mouse spermatozoa. Proc Natl Acad Sci U S A. 2011;108:14342-7 pubmed publisher
    ..This enhanced motility requires Ca(2+) entry via cation channel of sperm (CatSper) Ca(2+)-selective ion channels in the sperm tail...
  3. Kirichok Y, Navarro B, Clapham D. Whole-cell patch-clamp measurements of spermatozoa reveal an alkaline-activated Ca2+ channel. Nature. 2006;439:737-40 pubmed
    ..This current is not present in spermatozoa lacking the sperm-specific putative ion channel protein, CatSper1. This plasma membrane protein of the six transmembrane-spanning ion channel superfamily is specifically localized ..
  4. Marquez B, Ignotz G, Suarez S. Contributions of extracellular and intracellular Ca2+ to regulation of sperm motility: Release of intracellular stores can hyperactivate CatSper1 and CatSper2 null sperm. Dev Biol. 2007;303:214-21 pubmed
    ..In sperm from CatSper1 or CatSper2 null mice, which lack functional flagellar alkaline-activated calcium currents, 50 microM thimerosal ..
  5. Liu J, Xia J, Cho K, Clapham D, Ren D. CatSperbeta, a novel transmembrane protein in the CatSper channel complex. J Biol Chem. 2007;282:18945-52 pubmed
    ..Using a transgenic approach, a CatSper1 complex was purified from mouse testis that contained heat shock protein 70-2, a testis-specific chaperone, and ..
  6. Ren D, Navarro B, Perez G, Jackson A, Hsu S, Shi Q, et al. A sperm ion channel required for sperm motility and male fertility. Nature. 2001;413:603-9 pubmed
    ..Here we describe a putative sperm cation channel, CatSper, whose amino-acid sequence most closely resembles a single, six-transmembrane-spanning repeat of the voltage-..
  7. Ho K, Wolff C, Suarez S. CatSper-null mutant spermatozoa are unable to ascend beyond the oviductal reservoir. Reprod Fertil Dev. 2009;21:345-50 pubmed
    ..To test this hypothesis, the behaviour of CatSper-null mouse spermatozoa in the oviduct was compared with that of spermatozoa from heterozygotes...
  8. Qi H, Moran M, Navarro B, Chong J, Krapivinsky G, Krapivinsky L, et al. All four CatSper ion channel proteins are required for male fertility and sperm cell hyperactivated motility. Proc Natl Acad Sci U S A. 2007;104:1219-23 pubmed
    ..Hyperactivation requires CatSper1 and CatSper2 putative ion channel genes, but the function of two other related genes (CatSper3 and CatSper4) is ..
  9. Carlson A, Quill T, Westenbroek R, Schuh S, Hille B, Babcock D. Identical phenotypes of CatSper1 and CatSper2 null sperm. J Biol Chem. 2005;280:32238-44 pubmed
    Among several candidate Ca(2+) entry channels in sperm, only CatSper1 and CatSper2 are known to have required roles in male fertility...

More Information

Publications35

  1. Carlson A, Westenbroek R, Quill T, Ren D, Clapham D, Hille B, et al. CatSper1 required for evoked Ca2+ entry and control of flagellar function in sperm. Proc Natl Acad Sci U S A. 2003;100:14864-8 pubmed
    ..Here, we show that mouse CatSper1 is essential for depolarization-evoked Ca2+ entry and for hyperactivated movement, a key flagellar function...
  2. Navarro B, Kirichok Y, Clapham D. KSper, a pH-sensitive K+ current that controls sperm membrane potential. Proc Natl Acad Sci U S A. 2007;104:7688-92 pubmed
    ..reproductive tract, the spermatozoan cytoplasm alkalinizes, which in turn activates a Ca2+-selective current (I(CatSper)) required for hyperactivated motility...
  3. Xia J, Reigada D, Mitchell C, Ren D. CATSPER channel-mediated Ca2+ entry into mouse sperm triggers a tail-to-head propagation. Biol Reprod. 2007;77:551-9 pubmed
    ..In addition, CatSper1-mutant sperm have lower intracellular ATP levels than wild-type sperm...
  4. Wang H, Liu J, Cho K, Ren D. A novel, single, transmembrane protein CATSPERG is associated with CATSPER1 channel protein. Biol Reprod. 2009;81:539-44 pubmed publisher
    All four CATSPER channel pore-forming subunits (CATSPER1-4) are localized in the sperm principal piece...
  5. Zeng X, Yang C, Kim S, Lingle C, Xia X. Deletion of the Slo3 gene abolishes alkalization-activated K+ current in mouse spermatozoa. Proc Natl Acad Sci U S A. 2011;108:5879-84 pubmed publisher
    ..The properties of I(Kres) suggest that it likely represents outward monovalent cation flux through CatSper channels...
  6. Nikpoor P, Mowla S, Movahedin M, Ziaee S, Tiraihi T. CatSper gene expression in postnatal development of mouse testis and in subfertile men with deficient sperm motility. Hum Reprod. 2004;19:124-8 pubmed
    ..for Ca2+ channels residing in sperm has led to the recent cloning and characterization of a novel gene, named CatSper, which codes for a unique Ca2+ channel expressed exclusively in the testis...
  7. Luo S, Jia J, Hu H, Ma W, Jiao Y, Dong J. [Yijingfang increases the expression of CatSper1 in mice]. Zhonghua Nan Ke Xue. 2010;16:1047-51 pubmed
    To observe the effects of Yijingfang on CatSper1 in the mouse model of cyclophosphamide-induced oligoasthenospermia...
  8. Wang H, Liu M, Li N, Luo T, Zheng L, Zeng X. Bisphenol A Impairs Mature Sperm Functions by a CatSper-Relevant Mechanism. Toxicol Sci. 2016;152:145-54 pubmed publisher
    ..reaction (AR) ratio together with the expression/current levels of the sperm-specific Ca(2+ )channel (CatSper) and K(+ )channel (KSper) were examined...
  9. Chung J, Miki K, Kim D, Shim S, Shi H, Hwang J, et al. CatSperζ regulates the structural continuity of sperm Ca2+ signaling domains and is required for normal fertility. elife. 2017;6: pubmed publisher
    ..the Gm7068 (CatSpere) and Tex40 (CatSperz) genes encode novel subunits of a 9-subunit CatSper ion channel complex...
  10. Xia J, Ren D. The BSA-induced Ca2+ influx during sperm capacitation is CATSPER channel-dependent. Reprod Biol Endocrinol. 2009;7:119 pubmed publisher
    ..in intracellular calcium concentration were studied using Fluo-4 and Fura-2 calcium imaging with wild-type and Catsper1 knockout mouse sperm...
  11. Mata Rocha M, Hernandez Sanchez J, Guarneros G, de la Chesnaye E, Sánchez Tusié A, Trevino C, et al. The transcription factors Sox5 and Sox9 regulate Catsper1 gene expression. FEBS Lett. 2014;588:3352-60 pubmed publisher
    ..In spite of its central role in male fertility, the transcriptional mechanisms that regulate Catsper1 expression are ill defined...
  12. Ernesto J, Weigel Muñoz M, Battistone M, Vasen G, Martínez López P, Orta G, et al. CRISP1 as a novel CatSper regulator that modulates sperm motility and orientation during fertilization. J Cell Biol. 2015;210:1213-24 pubmed publisher
    ..Moreover, patch clamping of sperm revealed that CRISP1 has the ability to regulate CatSper, the principal sperm Ca(2+) channel involved in hyperactivation and essential for fertility...
  13. Zeng X, Yang C, Xia X, Liu M, Lingle C. SLO3 auxiliary subunit LRRC52 controls gating of sperm KSPER currents and is critical for normal fertility. Proc Natl Acad Sci U S A. 2015;112:2599-604 pubmed publisher
    ..In mice, the Ca(2+) conductance (alkalization-activated Ca(2+)-permeable sperm channel, CATSPER) arises from an ensemble of CATSPER subunits, whereas the K(+) conductance (sperm pH-regulated K(+) current, ..
  14. Mata Rocha M, Alvarado Cuevas E, Hernandez Sanchez J, Cerecedo D, Felix R, Hernández Reyes A, et al. Molecular cloning and analysis of the Catsper1 gene promoter. Mol Hum Reprod. 2013;19:336-47 pubmed publisher
    ..Here, we report the cloning and characterization of the promoter regions in the human and murine Catsper1 genes...
  15. Miki K, Clapham D. Rheotaxis guides mammalian sperm. Curr Biol. 2013;23:443-52 pubmed publisher
    ..Rotation requires CatSper channels, presumably by enabling Ca(2+) influx...
  16. Chung J, Navarro B, Krapivinsky G, Krapivinsky L, Clapham D. A novel gene required for male fertility and functional CATSPER channel formation in spermatozoa. Nat Commun. 2011;2:153 pubmed
    ..Each of the CatSper1-4 genes encodes a subunit of a tetramer surrounding a Ca(2+)-selective pore, in analogy with other six-..
  17. Chávez J, Ferreira J, Butler A, De La Vega Beltrán J, Treviño C, Darszon A, et al. SLO3 K+ channels control calcium entry through CATSPER channels in sperm. J Biol Chem. 2014;289:32266-75 pubmed publisher
    ..sperm-specific potassium channel (SLO3) controls Ca(2+) entry into sperm through a sperm-specific Ca(2+) channel, CATSPER, in a totally unanticipated manner...
  18. Li H, Ding X, Guan H, Xiong C. Inhibition of human sperm function and mouse fertilization in vitro by an antibody against cation channel of sperm 1: the contraceptive potential of its transmembrane domains and pore region. Fertil Steril. 2009;92:1141-6 pubmed publisher
    To explore the contraceptive potential of the CatSper1 transmembrane domains and pore region in vitro. In vitro study with human sperm and mouse fertilization. Andrology laboratory of an academic research center...
  19. Miyata H, Satouh Y, Mashiko D, Muto M, Nozawa K, Shiba K, et al. Sperm calcineurin inhibition prevents mouse fertility with implications for male contraceptive. Science. 2015;350:442-5 pubmed publisher
    ..Because human spermatozoa contain PPP3CC and PPP3R2 as a form of calcineurin, inhibition of this sperm-specific calcineurin may lead to the development of a reversible male contraceptive that would target spermatozoa in the epididymis. ..
  20. Rezaian J, Movahedin M, Mowla S. CatSper genes expression, semen characteristics and histology of testes in the contusive spinal cord-injured mice model. Spinal Cord. 2009;47:76-81 pubmed publisher
    Experimental study. A recently characterized CatSper genes, encodes for unique Ca(2+) channels in the testes, where they play essential roles in sperm motility...
  21. Zeng X, Navarro B, Xia X, Clapham D, Lingle C. Simultaneous knockout of Slo3 and CatSper1 abolishes all alkalization- and voltage-activated current in mouse spermatozoa. J Gen Physiol. 2013;142:305-13 pubmed publisher
    ..After deletion of any of four CATSPER subunit genes (CATSPER1-4), the major remaining current in mouse sperm is alkalization-activated KSPER current...
  22. Chung J, Shim S, Everley R, Gygi S, Zhuang X, Clapham D. Structurally distinct Ca(2+) signaling domains of sperm flagella orchestrate tyrosine phosphorylation and motility. Cell. 2014;157:808-22 pubmed publisher
    ..Here, using genetics, super-resolution fluorescence microscopy, and phosphoproteomics, we investigate the CatSper-dependent mechanisms underlying this flagellar switch...
  23. Li H, Ding X, Guo C, Guan H, Xiong C. Immunization of male mice with B-cell epitopes in transmembrane domains of CatSper1 inhibits fertility. Fertil Steril. 2012;97:445-52 pubmed publisher
    To evaluate the contraceptive ability of two B-cell epitopes in CatSper1. In vivo study with mice. University laboratory animal service center. BALB/c mice...
  24. Podlaha O, Webb D, Tucker P, Zhang J. Positive selection for indel substitutions in the rodent sperm protein catsper1. Mol Biol Evol. 2005;22:1845-52 pubmed
    b>Catsper1 is a voltage-gated calcium channel located in the plasma membrane of the sperm tail and is necessary for sperm motility and fertility in mice...
  25. Jiménez Badillo S, Oviedo N, Hernández Guzmán C, Gonzalez Mariscal L, Hernandez Sanchez J. Catsper1 promoter is bidirectional and regulates the expression of a novel lncRNA. Sci Rep. 2017;7:13351 pubmed publisher
    The Catsper1 gene, whose expression is restricted to male germ cells, has great importance in reproductive biology because of its function in sperm motility and fertilization...
  26. Navarrete F, García Vázquez F, Alvau A, Escoffier J, Krapf D, Sánchez Cárdenas C, et al. Biphasic role of calcium in mouse sperm capacitation signaling pathways. J Cell Physiol. 2015;230:1758-1769 pubmed publisher
    ..Interestingly, contrary to wild-type mouse sperm, sperm from CatSper1 KO mice underwent PKA activation and an increase in tyrosine phosphorylation upon incubation in nominal zero Ca(2+..