Gene Symbol: Cat
Description: catalase
Alias: 2210418N07, Cas-1, Cas1, Cs-1, catalase, catalase 1
Species: mouse
Products:     Cat

Top Publications

  1. Brites P, Motley A, Gressens P, Mooyer P, Ploegaert I, Everts V, et al. Impaired neuronal migration and endochondral ossification in Pex7 knockout mice: a model for rhizomelic chondrodysplasia punctata. Hum Mol Genet. 2003;12:2255-67 pubmed
    ..These findings demonstrate that Pex7 knockout mice provide an important model to study the role of peroxisomal functioning in the pathogenesis of the human disorder...
  2. Ho Y, Xiong Y, Ma W, Spector A, Ho D. Mice lacking catalase develop normally but show differential sensitivity to oxidant tissue injury. J Biol Chem. 2004;279:32804-12 pubmed
    b>Catalase plays a major role in cellular antioxidant defense by decomposing hydrogen peroxide, thereby preventing the generation of hydroxyl radical by the Fenton reaction...
  3. Nenicu A, Lüers G, Kovacs W, David M, Zimmer A, Bergmann M, et al. Peroxisomes in human and mouse testis: differential expression of peroxisomal proteins in germ cells and distinct somatic cell types of the testis. Biol Reprod. 2007;77:1060-72 pubmed
    ..2 for side chain oxidation of cholesterol, were found in Sertoli cells, whereas Leydig cells were enriched in catalase and ABCD2...
  4. Johnson R, Ho Y, Yu D, Kuypers F, Ravindranath Y, Goyette G. The effects of disruption of genes for peroxiredoxin-2, glutathione peroxidase-1, and catalase on erythrocyte oxidative metabolism. Free Radic Biol Med. 2010;48:519-25 pubmed publisher
    ..Additional experiments with mice with disrupted catalase or glutathione peroxidase (Gpx1) genes showed that Gpx1 is the only erythrocyte enzyme that reduces organic ..
  5. Godin N, Liu F, Lau G, Brezniceanu M, Chenier I, Filep J, et al. Catalase overexpression prevents hypertension and tubular apoptosis in angiotensinogen transgenic mice. Kidney Int. 2010;77:1086-97 pubmed publisher
    ..Here, we determined whether overexpression of catalase to decrease oxidant injury in the proximal tubular cells could reverse these abnormalities...
  6. Grabenbauer M, Fahimi H, Baumgart E. Detection of peroxisomal proteins and their mRNAs in serial sections of fetal and newborn mouse organs. J Histochem Cytochem. 2001;49:155-64 pubmed
    ..Using this protocol, we studied the developmental changes in localization of the peroxisomal marker enzymes catalase (CAT) and acyl-CoA oxidase 1 (AOX), the key regulatory enzyme of peroxisomal beta-oxidation, at the protein and ..
  7. Rapti K, Diokmetzidou A, Kloukina I, Milner D, Varela A, Davos C, et al. Opposite effects of catalase and MnSOD ectopic expression on stress induced defects and mortality in the desmin deficient cardiomyopathy model. Free Radic Biol Med. 2017;110:206-218 pubmed publisher
    ..In order to verify these findings in vivo, we generated transgenic animals overexpressing SOD2 (MnSOD) and/or catalase in the heart and crossed them with des-/- mice, thus allowing us to evaluate the contribution of oxidative injury ..
  8. Muppala V, Lin C, Lee Y. The role of HNF-1alpha in controlling hepatic catalase activity. Mol Pharmacol. 2000;57:93-100 pubmed
    ..However, activities of cytosolic glutathione peroxidase and catalase, two enzymes responsible for detoxification of hydrogen peroxide within cells, were reduced specifically in liver ..
  9. Carver E, Issel Tarver L, Rine J, Olsen A, Stubbs L. Location of mouse and human genes corresponding to conserved canine olfactory receptor gene subfamilies. Mamm Genome. 1998;9:349-54 pubmed
    ..Combined with recently published studies, these data link the four conserved olfactory gene subfamilies to homologous regions of the human, dog, and mouse genomes. ..

More Information


  1. Chung Y, Jeong D, Noh O, Park Y, Kang S, Lee M, et al. Antioxidative role of selenoprotein W in oxidant-induced mouse embryonic neuronal cell death. Mol Cells. 2009;27:609-13 pubmed publisher
    ..Taken together, our findings suggest that SelW plays an important role in protection of neurons from oxidative stress during neuronal development. ..
  2. Kent J, Lee M, Schedl A, Boyle S, Fantes J, Powell M, et al. The reticulocalbin gene maps to the WAGR region in human and to the Small eye Harwell deletion in mouse. Genomics. 1997;42:260-7 pubmed
    ..Loss of the reticulocalbin gene could contribute to the early lethality of SeyH and SeyDey homozygotes. ..
  3. Ganschow R, Schimke R. Murine catalase phenotypes. Biochem Genet. 1970;4:157-67 pubmed
  4. Luo D, Rando T. The regulation of catalase gene expression in mouse muscle cells is dependent on the CCAAT-binding factor NF-Y. Biochem Biophys Res Commun. 2003;303:609-18 pubmed
    b>Catalase is an antioxidant enzyme whose expression is transcriptionally regulated and tissue-specific. The level of expression determines, in part, the susceptibility of a cell to oxidative stress...
  5. Moon J, Choi S, Heo C, Kim H, Kim H. α-Syntrophin stabilizes catalase to reduce endogenous reactive oxygen species levels during myoblast differentiation. FEBS J. 2017;284:2052-2065 pubmed publisher
    ..Among antioxidant enzymes, catalase was significantly decreased during differentiation of SNKD cells without changes at the mRNA level...
  6. Johnson R, Goyette G, Ravindranath Y, Ho Y. Hemoglobin autoxidation and regulation of endogenous H2O2 levels in erythrocytes. Free Radic Biol Med. 2005;39:1407-17 pubmed
    ..Methemoglobin and the rate of catalase inactivation by 3-amino-2,4,5-triazole (3-AT) were determined...
  7. Zmijewski J, Lorne E, Zhao X, Tsuruta Y, Sha Y, Liu G, et al. Antiinflammatory effects of hydrogen peroxide in neutrophil activation and acute lung injury. Am J Respir Crit Care Med. 2009;179:694-704 pubmed publisher
    ..that increases in intracellular H(2)O(2) may play in acute inflammatory processes, we examined the effects of catalase inhibition or the absence of catalase on LPS-induced inflammatory responses...
  8. Chang S, Chen Y, Zhao X, Chenier I, Tran S, Sauvé A, et al. Catalase prevents maternal diabetes-induced perinatal programming via the Nrf2-HO-1 defense system. Diabetes. 2012;61:2565-74 pubmed
    We investigated whether overexpression of catalase (CAT) in renal proximal tubular cells (RPTCs) could prevent the programming of hypertension and kidney disease in the offspring of dams with maternal diabetes...
  9. Reimer D, Singh S. Distinct mRNA-binding proteins interacting with short repeat sequences of the 3' UTR may be involved in the post-transcriptional regulation of the mouse catalase gene, Cas-1. DNA Cell Biol. 1996;15:317-28 pubmed
    The 3' untranslated region (UTR) of the mouse catalase gene (Cas-1) is demonstrated to be an active site for specific protein interactions...
  10. Branchetti E, Sainger R, Poggio P, Grau J, Patterson Fortin J, Bavaria J, et al. Antioxidant enzymes reduce DNA damage and early activation of valvular interstitial cells in aortic valve sclerosis. Arterioscler Thromb Vasc Biol. 2013;33:e66-74 pubmed publisher
    ..Because ROS cause DNA damage and transcriptional activation we investigated the relationship between ROS, DNA damage response, and transdifferentiation of VICs...
  11. Bloch K, Shichman E, Vorobeychik M, Bloch D, Vardi P. Catalase expression in pancreatic alpha cells of diabetic and non-diabetic mice. Histochem Cell Biol. 2007;127:227-32 pubmed
    ..very sensitive to oxidative stress, probably due to the extremely low level of anti-oxidant enzymes, particularly catalase. In contrast to beta cells, pancreatic alpha cells are significantly more resistant to diabetogenic toxins...
  12. Li D, Lai Y, Yue Y, Rabinovitch P, Hakim C, Duan D. Ectopic catalase expression in mitochondria by adeno-associated virus enhances exercise performance in mice. PLoS ONE. 2009;4:e6673 pubmed publisher
    ..Here, we tested whether delivering catalase to the mitochondria, a site of free radical production in contracting muscle, could improve treadmill performance ..
  13. Basisty N, Dai D, Gagnidze A, Gitari L, Fredrickson J, Maina Y, et al. Mitochondrial-targeted catalase is good for the old mouse proteome, but not for the young: 'reverse' antagonistic pleiotropy?. Aging Cell. 2016;15:634-45 pubmed publisher
    ..We have previously shown that transgenic expression of the antioxidant enzyme catalase targeted to the mitochondria (mCAT) in mice reduces ROS, attenuates age-related disease, and increases lifespan...
  14. Jang B, Kim D, Park J, Kwon T, Kim S, Song D, et al. Induction of cyclooxygenase-2 in macrophages by catalase: role of NF-kappaB and PI3K signaling pathways. Biochem Biophys Res Commun. 2004;316:398-406 pubmed
    Induction of COX-2 by catalase in smooth muscle cells, endothelial cells, and neuronal cells has been previously reported. However, the mechanism by which catalase up-regulates COX-2 remains poorly understood...
  15. Charlagorla P, Liu J, Patel M, RUSHBROOK J, Zhang M. Loss of plasma membrane integrity, complement response and formation of reactive oxygen species during early myocardial ischemia/reperfusion. Mol Immunol. 2013;56:507-12 pubmed publisher
    ..b>Catalase transgenic mice were not protected from LPMI at 1-h reperfusion compared with WT mice, but had 69% less LPMI at 3-..
  16. Kim S, Cheresh P, Jablonski R, Morales Nebreda L, Cheng Y, Hogan E, et al. Mitochondrial catalase overexpressed transgenic mice are protected against lung fibrosis in part via preventing alveolar epithelial cell mitochondrial DNA damage. Free Radic Biol Med. 2016;101:482-490 pubmed publisher
    ..To determine whether transgenic mice that express mitochondrial-targeted catalase (MCAT) have reduced lung fibrosis following exposure to asbestos or bleomycin and, if so, whether this occurs in ..
  17. Noh J, Kim Y, Gang G, Hwang J, Lee H, Ly S, et al. Hepatoprotective effects of chestnut (Castanea crenata) inner shell extract against chronic ethanol-induced oxidative stress in C57BL/6 mice. Food Chem Toxicol. 2011;49:1537-43 pubmed publisher
    ..Moreover, CISE treatment with ethanol decreased CYP2E1 expression and increased activities of catalase and superoxide dismutase, which were significantly inhibited by treatment with ethanol alone...
  18. Oettinger M, Stanger B, Schatz D, Glaser T, Call K, Housman D, et al. The recombination activating genes, RAG 1 and RAG 2, are on chromosome 11p in humans and chromosome 2p in mice. Immunogenetics. 1992;35:97-101 pubmed
    ..Guided by the chromosomal localization of the human recombination activating genes, we have also mapped the location of the mouse Rag locus. ..
  19. Dickerman R, Feinstein R, Grahn D. Position of the acatalasemia gene in linkage group V of the mouse. J Hered. 1968;59:177-8 pubmed
  20. Osoegawa K, Tateno M, Woon P, Frengen E, Mammoser A, Catanese J, et al. Bacterial artificial chromosome libraries for mouse sequencing and functional analysis. Genome Res. 2000;10:116-28 pubmed
    ..The low rate of chimerism, approximately 1%, and the low level of detected rearrangements support the anticipated usefulness of the BAC libraries for genome research...
  21. Gu W, Hecht N. Developmental expression of glutathione peroxidase, catalase, and manganese superoxide dismutase mRNAs during spermatogenesis in the mouse. J Androl. 1996;17:256-62 pubmed
    We have examined in mouse testis the steady-state levels of mRNAs encoding glutathione peroxidase (GSHPx), catalase (CAT), and superoxide dismutase 2 (SOD-2), three enzymes essential for the antioxidant protection of cells...
  22. Xu Y, Demarest K, Hitzemann R, Sikela J. Gene coding variant in Cas1 between the C57BL/6J and DBA/2J inbred mouse strains: linkage to a QTL for ethanol-induced locomotor activation. Alcohol Clin Exp Res. 2002;26:1-7 pubmed
    ..2001). A potential candidate gene in this region is Cas1, which codes for catalase. The current studies were conducted to determine (a) if there was difference in the open reading frame (ORF) of ..
  23. Pirson M, Knoops B. Expression of peroxiredoxins and thioredoxins in the mouse spinal cord during embryonic development. J Comp Neurol. 2015;523:2599-617 pubmed publisher
    ..These striking expression patterns suggest novel functions of these enzymes at these stages and offer clues to the role of the Trx/Prdx system during embryonic development of the spinal cord. ..
  24. Meruelo D, Offer M, Rossomando A. Evidence for a major cluster of lymphocyte differentiation antigens on murine chromosome 2. Proc Natl Acad Sci U S A. 1982;79:7460-4 pubmed
    ..In addition, at least one locus (and probably more) affecting susceptibility to leukemia induction is found within this gene cluster. ..
  25. Gautam M, Mudd J, Copeland N, Gilbert D, Jenkins N, Merlie J. Characterization and mapping of the Rapsn gene encoding the 43-kDa acetylcholine receptor-associated protein. Genomics. 1994;24:366-9 pubmed
    ..Finally, the 43K locus, designated Rapsn, has been mapped to the central region of mouse chromosome 2. ..
  26. Jansen S, Pantaleon M, Kaye P. Characterization and regulation of monocarboxylate cotransporters Slc16a7 and Slc16a3 in preimplantation mouse embryos. Biol Reprod. 2008;79:84-92 pubmed publisher
    ..punctate, vesicular expression throughout blastomeres, partially colocalizing in peroxisomes with peroxisomal catalase (CAT). In contrast to SLC16A3 and SLC16A1, SLC16A7 and CAT demonstrate upregulation in the absence of glucose...
  27. Lenzen S, Drinkgern J, Tiedge M. Low antioxidant enzyme gene expression in pancreatic islets compared with various other mouse tissues. Free Radic Biol Med. 1996;20:463-6 pubmed
    Using a sensitive Northern blot hybridization technique, gene expression of superoxide dismutase (SOD), catalase, and glutathione peroxidase was studied in pancreatic islets and for comparison in various other mouse tissues (liver, kidney,..
  28. Manrique H, Miquel M, Aragon C. Acute administration of 3-nitropropionic acid, a reactive oxygen species generator, boosts ethanol-induced locomotor stimulation. New support for the role of brain catalase in the behavioural effects of ethanol. Neuropharmacology. 2006;51:1137-45 pubmed
    The antioxidant enzyme catalase by reacting with H(2)O(2), forms the compound known as compound I (catalase-H(2)O(2)). This compound is able to oxidise ethanol to acetaldehyde in the CNS...
  29. Khan J, Black S. Developmental changes in murine brain antioxidant enzymes. Pediatr Res. 2003;54:77-82 pubmed
    ..analysis, and enzymatic activity of the antioxidant system-copper-zinc superoxide dismutase (SOD), manganese SOD, catalase, and glutathione peroxidase, as well as reduced glutathione level as an indicator of the nonenzymatic system-in ..
  30. Wang R, Islam B, Bridges A, Sharman S, Hu M, Hou Y, et al. cGMP Signaling Increases Antioxidant Gene Expression by Activating Forkhead Box O3A in the Colon Epithelium. Am J Pathol. 2017;187:377-389 pubmed publisher
    ..Treatment of human colonic biopsy specimens with 8Br-cGMP also activated catalase and manganese superoxide dismutase expression, indicating that this pathway is conserved in humans...
  31. Ge W, Ge W, Zhang Y, Han X, Ren J. Cardiac-specific overexpression of catalase attenuates paraquat-induced myocardial geometric and contractile alteration: role of ER stress. Free Radic Biol Med. 2010;49:2068-77 pubmed publisher
    ..This study examined the influence of cardiac-specific overexpression of catalase, an antioxidant detoxifying H(2)O(2), on paraquat-induced myocardial geometric and functional alterations, with a ..
  32. Ahlemeyer B, Gottwald M, Baumgart Vogt E. Deletion of a single allele of the Pex11? gene is sufficient to cause oxidative stress, delayed differentiation and neuronal death in mouse brain. Dis Model Mech. 2012;5:125-40 pubmed publisher
    ..SOD2 was upregulated in neurons from Pex11?(+/-) mice, but not from Pex11?(-/-) animals, whereas the level of catalase remained unchanged in neurons from Pex11?(+/-) mice and was reduced in those from Pex11?(-/-) mice, suggesting a ..
  33. Schnabel D, Salas Vidal E, Narvaez V, Sánchez Carbente M, Hernández García D, Cuervo R, et al. Expression and regulation of antioxidant enzymes in the developing limb support a function of ROS in interdigital cell death. Dev Biol. 2006;291:291-9 pubmed
    ..We found that the genes encoding the superoxide dismutases and catalase are expressed in autopod, but they are downregulated in the interdigital regions at the time ROS levels increased ..
  34. Shaffer J, Preston K. Molecular analysis of an acatalasemic mouse mutant. Biochem Biophys Res Commun. 1990;173:1043-50 pubmed
    The Csb acatalasemia mouse mutant differentially expresses reduced levels of catalase activity in a tissue specific manner...
  35. Wang D, Tsutsui K, Sano K, Masuoka N, Kira S. cDNA cloning and expression of mutant catalase from the hypocatalasemic mouse: comparison with the acatalasemic mutant. Biochim Biophys Acta. 2001;1522:217-20 pubmed
    Mutant catalase cDNAs from the hypocatalasemic and acatalasemic mice were cloned and expressed in bacteria. A novel missense mutation, Asp (AAT) to Ser (AGT), was identified at amino acid position 439 of the hypocatalasemic catalase...
  36. Reynaert N, Aesif S, McGovern T, Brown A, Wouters E, Irvin C, et al. Catalase overexpression fails to attenuate allergic airways disease in the mouse. J Immunol. 2007;178:3814-21 pubmed the pathophysiology of allergic airway disease, we comparatively evaluated mice systemically overexpressing catalase, a major antioxidant enzyme that detoxifies hydrogen peroxide, and C57BL/6 strain matched controls in the OVA ..
  37. Feinstein R, Jaroslow B, Howard J. Molecular location of the genetic lesion in the acatalasemic mouse. Biochem Genet. 1972;6:263-73 pubmed
  38. Kaczmarek K, Studencka M, Meinhardt A, Wieczerzak K, Thoms S, Engel W, et al. Overexpression of peroxisomal testis-specific 1 protein induces germ cell apoptosis and leads to infertility in male mice. Mol Biol Cell. 2011;22:1766-79 pubmed publisher
    ..The PXT1-BAT3 association leads to PXT1 relocation from the cytoplasm to the nucleus. In summary, we demonstrated that PXT1 induces apoptosis via the BH3-like domain and that this process is inhibited by BAT3. ..
  39. Dai D, Chen T, Wanagat J, Laflamme M, Marcinek D, Emond M, et al. Age-dependent cardiomyopathy in mitochondrial mutator mice is attenuated by overexpression of catalase targeted to mitochondria. Aging Cell. 2010;9:536-44 pubmed publisher
    ..oxygen species (ROS) was tested by crossing Polg(m/m) mice with mice that overexpress mitochondrial targeted catalase (mCAT). All of the above phenotypes were partially rescued in Polg(m/m)/mCAT mice...
  40. Goldfischer S, Roheim P, Edelstein D, Essner E. Hypolipidemia in a mutant strain of "acatalasemic" mice. Science. 1971;173:65-6 pubmed
    Mutant "acatalasemicm" mice have an unstable catalase in hepatic and renal peroxisomnes that is readily degraded, apparently into peroxidase subunits...
  41. Yang H, Shi M, VanRemmen H, Chen X, Vijg J, Richardson A, et al. Reduction of pressor response to vasoconstrictor agents by overexpression of catalase in mice. Am J Hypertens. 2003;16:1-5 pubmed
    ..produced H(2)O(2) on blood pressure (BP) was examined using a transgenic mouse model (hCatTg(+/0)) in which catalase is overexpressed...
  42. Bonini M, Siraki A, Atanassov B, Mason R. Immunolocalization of hypochlorite-induced, catalase-bound free radical formation in mouse hepatocytes. Free Radic Biol Med. 2007;42:530-40 pubmed
    ..Intracellular concentrations of H(2)O(2) are modulated by its rate of production and its rate of decomposition by catalase and peroxidases...
  43. Park Y, You S, Cho S, Jeon H, Lee S, Cho D, et al. Eccentric localization of catalase to protect chromosomes from oxidative damages during meiotic maturation in mouse oocytes. Histochem Cell Biol. 2016;146:281-8 pubmed publisher
    ..Here, we show that catalase (CAT) is present in mouse oocytes to protect the genome from oxidative damage during meiotic maturation...
  44. Siracusa L, Silan C, Justice M, Mercer J, Bauskin A, Ben Neriah Y, et al. A molecular genetic linkage map of mouse chromosome 2. Genomics. 1990;6:491-504 pubmed
    ..Comparisons between the mouse and the human genomes indicate that mouse chromosome 2 contains regions homologous to at least six human chromosomes. Mouse models for human diseases are discussed. ..
  45. Nagase T, Shimozawa N, Takemoto Y, Suzuki Y, Komori M, Kondo N. Peroxisomal localization in the developing mouse cerebellum: implications for neuronal abnormalities related to deficiencies in peroxisomes. Biochim Biophys Acta. 2004;1671:26-33 pubmed
    ..As peroxisomes in glial cells may control the development of neurons, the neuron-glial interaction and mechanisms of developing central nervous systems deserve ongoing attention. ..
  46. Muller F, Liu Y, Van Remmen H. Complex III releases superoxide to both sides of the inner mitochondrial membrane. J Biol Chem. 2004;279:49064-73 pubmed
    ..of (mitochondrial matrix) aconitase inhibition, performed in the presence of exogenous superoxide dismutase and catalase, confirmed this hypothesis...
  47. Hanke N, Finch J, Bowden G. Loss of catalase increases malignant mouse keratinocyte cell growth through activation of the stress activated JNK pathway. Mol Carcinog. 2008;47:349-60 pubmed
    ..mouse squamous cell carcinoma (6M90) was modified to develop a cell line with an introduced Tet-responsive catalase transgene (MTOC2)...
  48. Aikoh H, Ogata M. Levels of metallic mercury and mercuric ion in the venous and arterial bloods of normal and acatalasemic mice following exposure to mercury vapor. Physiol Chem Phys Med NMR. 1988;20:177-81 pubmed
    ..The significance of metallic mercury in plasma for distribution of mercury in organs is discussed. ..
  49. Rindler P, Cacciola A, Kinter M, Szweda L. Catalase-dependent H2O2 consumption by cardiac mitochondria and redox-mediated loss in insulin signaling. Am J Physiol Heart Circ Physiol. 2016;311:H1091-H1096 pubmed publisher
    We have recently demonstrated that catalase content in mouse cardiac mitochondria is selectively elevated in response to high dietary fat, a nutritional state associated with oxidative stress and loss in insulin signaling...
  50. Zhang X, Dong F, Li Q, Borgerding A, Klein A, Ren J. Cardiac overexpression of catalase antagonizes ADH-associated contractile depression and stress signaling after acute ethanol exposure in murine myocytes. J Appl Physiol (1985). 2005;99:2246-54 pubmed
    ..This study was designed to examine the impact of antioxidant catalase (CAT) on cardiac contractile response to ethanol and activation of stress signaling...
  51. Bjorkman J, Gould S, Crane D. Pex13, the mouse ortholog of the human peroxisome biogenesis disorder PEX13 gene: gene structure, tissue expression, and localization of the protein to peroxisomes. Genomics. 2002;79:162-8 pubmed
    ..We infer from these findings that targeted disruption of mouse Pex13 would provide an appropriate model for the study of PEX13 dysfunction in humans. ..
  52. Sánchez Carbente M, Castro Obregon S, Covarrubias L, Narvaez V. Motoneuronal death during spinal cord development is mediated by oxidative stress. Cell Death Differ. 2005;12:279-91 pubmed
    ..ROS were reduced in spinal cords cultured in the presence of a synthetic superoxide dismutase and catalase mimetic, with a concomitant reduction in cell death and an increase in the number of motoneurons...
  53. Foussal C, Lairez O, Calise D, Pathak A, Guilbeau Frugier C, Valet P, et al. Activation of catalase by apelin prevents oxidative stress-linked cardiac hypertrophy. FEBS Lett. 2010;584:2363-70 pubmed publisher
    ..These effects were concomitant to the increase in mRNA expression and activity of catalase. Chronic treatment of mice with apelin attenuated pressure-overload-induced left ventricular hypertrophy...
  54. Miller L, Shapiro A, Wells P. Embryonic catalase protects against ethanol-initiated DNA oxidation and teratogenesis in acatalasemic and transgenic human catalase-expressing mice. Toxicol Sci. 2013;134:400-11 pubmed publisher
    ..Although catalase detoxifies hydrogen peroxide, embryonic catalase activity is only about 5% of maternal levels...
  55. Nilakantan V, Spear B, Glauert H. Liver-specific catalase expression in transgenic mice inhibits NF-kappaB activation and DNA synthesis induced by the peroxisome proliferator ciprofibrate. Carcinogenesis. 1998;19:631-7 pubmed
    ..To test this hypothesis, we have examined if hepatic catalase overexpression in peroxisome proliferator-treated mice influences the induction of cell proliferation or the ..
  56. Okuno Y, Matsuda M, Kobayashi H, Morita K, Suzuki E, Fukuhara A, et al. Adipose expression of catalase is regulated via a novel remote PPARgamma-responsive region. Biochem Biophys Res Commun. 2008;366:698-704 pubmed
    In adipose tissue of obese mice, the expression of catalase, an anti-oxidant enzyme, significantly decreases, which may cause insufficient elimination of hydrogen peroxide, but it does not in liver or skeletal muscle...
  57. Pendergrass K, Varghese S, Maiellaro Rafferty K, Brown M, Taylor W, Davis M. Temporal effects of catalase overexpression on healing after myocardial infarction. Circ Heart Fail. 2011;4:98-106 pubmed publisher
    ..We developed a tamoxifen-inducible, cardiomyocyte-specific, catalase-overexpressing mouse. Catalase overexpression was induced either 5 days before or after MI...
  58. Heit C, Marshall S, Singh S, Yu X, Charkoftaki G, Zhao H, et al. Catalase deletion promotes prediabetic phenotype in mice. Free Radic Biol Med. 2017;103:48-56 pubmed publisher
    ..However, it has also been identified as a signal transduction molecule. By metabolizing hydrogen peroxide, catalase protects cells and tissues against oxidative damage and may also influence signal transduction mechanisms...
  59. Goh J, Enns L, Fatemie S, Hopkins H, Morton J, Pettan Brewer C, et al. Mitochondrial targeted catalase suppresses invasive breast cancer in mice. BMC Cancer. 2011;11:191 pubmed publisher
    ..Transgenic mice expressing a human catalase gene (mCAT) were crossed with MMTV-PyMT transgenic mice that develop metastatic breast cancer...
  60. MacGregor T, Copeland N, Jenkins N, Giguere V. The murine gene for cellular retinoic acid-binding protein type II. Genomic organization, chromosomal localization, and post-transcriptional regulation by retinoic acid. J Biol Chem. 1992;267:7777-83 pubmed
    ..These results suggest that the up-regulation of CRABP-II mRNA levels by RA is mainly controlled by a post-transcriptional mechanism. ..
  61. Cong W, Ruan D, Xuan Y, Niu C, Tao Y, Wang Y, et al. Cardiac-specific overexpression of catalase prevents diabetes-induced pathological changes by inhibiting NF-κB signaling activation in the heart. J Mol Cell Cardiol. 2015;89:314-25 pubmed publisher
    b>Catalase is an antioxidant enzyme that specifically catabolizes hydrogen peroxide (H2O2)...
  62. Dao V, Floeren M, Kumpf S, Both C, Peter B, Balz V, et al. Catalase activity prevents exercise-induced up-regulation of vasoprotective proteins in venous tissue. J Cell Mol Med. 2011;15:2326-34 pubmed publisher
    ..Changes of vascular mRNA and protein levels and activity of eNOS, ecSOD and catalase were determined in aorta, heart, lung and vena cava...
  63. el Mouatassim S, Guerin P, Menezo Y. Expression of genes encoding antioxidant enzymes in human and mouse oocytes during the final stages of maturation. Mol Hum Reprod. 1999;5:720-5 pubmed
    The mRNA expression of five enzymes: catalase, Cu-Zn-superoxide dismutase (Cu-Zn-SOD), Mn-superoxide dismutase (Mn-SOD), glutathione peroxidase (GPX), and gamma-glutamylcysteine synthetase (GCS) each involved in protection against free ..
  64. Macedo D, de Vasconcelos S, dos Santos R, Aguiar L, Lima V, Viana G, et al. Cocaine alters catalase activity in prefrontal cortex and striatum of mice. Neurosci Lett. 2005;387:53-6 pubmed
    b>Catalase is one of the enzymes that convert hydrogen peroxide (H2O2) to H2O presenting a protective role against free radicals...
  65. Tome M, Lutz N, Briehl M. Overexpression of catalase or Bcl-2 delays or prevents alterations in phospholipid metabolism during glucocorticoid-induced apoptosis in WEHI7.2 cells. Biochim Biophys Acta. 2003;1642:149-62 pubmed
    Dexamethasone-treated WEHI7.2 mouse thymoma cells readily undergo apoptosis. WEHI7.2 variants that overexpress catalase (CAT38) or Bcl-2 (Hb12) show a delay or lack of apoptosis, respectively, when treated with dexamethasone...
  66. Venkatesan B, Mahimainathan L, Das F, Ghosh Choudhury N, Ghosh Choudhury G. Downregulation of catalase by reactive oxygen species via PI 3 kinase/Akt signaling in mesangial cells. J Cell Physiol. 2007;211:457-67 pubmed
    ..ROS have been shown to regulate expression of many antioxidant enzymes including catalase. The mechanism by which the expression of catalase protein is regulated by ROS is not precisely known...
  67. Hoeflich A, Fettscher O, Preta G, Lahm H, Kolb H, Wolf E, et al. Increased activity of catalase in tumor cells overexpressing IGFBP-2. Horm Metab Res. 2003;35:816-21 pubmed
    ..Among the tested antioxidative enzymes (catalase, superoxide-dismutase, glutathione peroxidase, glutathione S-transferase), only catalase enzyme activity was ..
  68. Carr W, Oberley Deegan R, Zhang Y, Oberley C, Oberley L, Dunnwald M. Antioxidant proteins and reactive oxygen species are decreased in a murine epidermal side population with stem cell-like characteristics. Histochem Cell Biol. 2011;135:293-304 pubmed publisher
    ..Immunostaining of neonatal cutaneous sections revealed that antioxidant enzymes [catalase, SOD2, gluthatione peroxidase-1 (GPx)] and ROS are localized predominantly to the epidermis...
  69. Bakin A, Stourman N, Sekhar K, Rinehart C, Yan X, Meredith M, et al. Smad3-ATF3 signaling mediates TGF-beta suppression of genes encoding Phase II detoxifying proteins. Free Radic Biol Med. 2005;38:375-87 pubmed
  70. Degen S, Schaefer L, Jamison C, Grant S, Fitzgibbon J, Pai J, et al. Characterization of the cDNA coding for mouse prothrombin and localization of the gene on mouse chromosome 2. DNA Cell Biol. 1990;9:487-98 pubmed
    ..The prothrombin locus lies on mouse chromosome 2, 1.8 +/- 1.3 map units proximal to the catalase locus. The gene order in this region is Cen-Acra-Cf-2-Cas-1-A-Tel...
  71. Choi S, Kim J, Li H, Shin K, Oh G, Lee Y, et al. KCa 3.1 upregulation preserves endothelium-dependent vasorelaxation during aging and oxidative stress. Aging Cell. 2016;15:801-10 pubmed publisher
    ..cells (MAECs) from aged wild-type and CerS2 null mice, superoxide dismutase (SOD) was upregulated, and catalase and glutathione peroxidase 1 (GPX1) were downregulated, when compared to MAECs from young and age-matched wild-..
  72. Janssen A, Gressens P, Grabenbauer M, Baumgart E, Schad A, Vanhorebeek I, et al. Neuronal migration depends on intact peroxisomal function in brain and in extraneuronal tissues. J Neurosci. 2003;23:9732-41 pubmed
  73. Liang L, Shou X, Zhao H, Ren G, Wang J, Wang X, et al. Antioxidant catalase rescues against high fat diet-induced cardiac dysfunction via an IKK?-AMPK-dependent regulation of autophagy. Biochim Biophys Acta. 2015;1852:343-52 pubmed publisher
    ..This study was designed to examine the role of the antioxidant catalase in high fat diet-induced changes in cardiac geometry and function as well as the underlying mechanism of action ..
  74. Dkhar P, Sharma R. Late-onset dietary restriction modulates protein carbonylation and catalase in cerebral hemispheres of aged mice. Cell Mol Neurobiol. 2014;34:307-13 pubmed publisher
    ..In the present study, we have evaluated the levels of protein carbonyls, ROS, and catalase in the cerebral hemispheres of young and aged mice...
  75. Cao C, Leng Y, Liu X, Yi Y, Li P, Kufe D. Catalase is regulated by ubiquitination and proteosomal degradation. Role of the c-Abl and Arg tyrosine kinases. Biochemistry. 2003;42:10348-53 pubmed
    b>Catalase is a major effector in the defense of aerobic cells against oxidative stress. Recent studies have shown that catalase activity is stimulated by the c-Abl and Arg tyrosine kinases...
  76. Olmos Y, Sánchez Gómez F, Wild B, García Quintáns N, Cabezudo S, Lamas S, et al. SirT1 regulation of antioxidant genes is dependent on the formation of a FoxO3a/PGC-1? complex. Antioxid Redox Signal. 2013;19:1507-21 pubmed publisher
    ..of several antioxidant genes in bovine aortic endothelial cells, including Mn superoxide dismutase (MnSOD), catalase, peroxiredoxins 3 and 5 (Prx3, Prx5), thioredoxin 2 (Trx2), thioredoxin reductase 2 (TR2), and uncoupling protein ..
  77. Rouquier S, Stubbs L, Gaillard Sanchez I, Giorgi D. Sequence and chromosomal localization of the mouse ortholog of the human olfactory receptor gene 912-93. Mamm Genome. 1999;10:1172-4 pubmed
  78. Shaffer J, Sutton R, Bewley G. Isolation of a cDNA clone for murine catalase and analysis of an acatalasemic mutant. J Biol Chem. 1987;262:12908-11 pubmed
    We have investigated the genetic control of murine catalase expression by analyzing catalase transcription and translation products from the tissues of control (Csa) and acatalasemic (Csb) mouse strains...
  79. Hwang I, Lee J, Huh J, Park J, Lee H, Ho Y, et al. Catalase deficiency accelerates diabetic renal injury through peroxisomal dysfunction. Diabetes. 2012;61:728-38 pubmed publisher
    ..Therefore, we investigated whether deficiency of catalase, a major peroxisomal antioxidant, accelerates DN through peroxisomal dysfunction and abnormal renal FFA ..
  80. Feinstein R, Howard J, Braun J, Seaholm J. Acatalasemic and hypocatalasemic mouse mutants. Genetics. 1966;53:923-33 pubmed
  81. Song J, Yoon D, Christensen R, Horvathova M, Thiagarajan P, Prchal J. HIF-mediated increased ROS from reduced mitophagy and decreased catalase causes neocytolysis. J Mol Med (Berl). 2015;93:857-66 pubmed publisher
    ..mass correlating with decreased Bnip3L transcripts (Bnip3L mediates reticulocyte mitophagy) and reduced catalase activity. During hypoxia, upregulated miR-21 resulted in low catalase activity in young RBCs...
  82. Sani M, Sebai H, Gadacha W, Boughattas N, Reinberg A, Mossadok B. Catalase activity and rhythmic patterns in mouse brain, kidney and liver. Comp Biochem Physiol B Biochem Mol Biol. 2006;145:331-7 pubmed
    ..Cytosolic-enzyme catalase (CAT) is a component of the antioxidant defence system that reduces hydrogen peroxide (H(2)O(2)) to water (H(2)O)...
  83. Sutton V, Wijffels G, Walker I, Hogarth P, McKenzie I. Genetic and biochemical characterization of antigens encoded by the Ly-24 (Pgp-1) locus. J Immunogenet. 1987;14:43-57 pubmed
    ..The possible reason for this unusual finding is discussed. ..
  84. Ahn J, Chen B, Shin B, Lee T, Cho J, Kim I, et al. Comparison of catalase immunoreactivity in the hippocampus between young, adult and aged mice and rats. Mol Med Rep. 2016;14:851-6 pubmed publisher
    b>Catalase (CAT) is an important antioxidant enzyme and is crucial in modulating synaptic plasticity in the brain...
  85. Yang F, Yang H, Ramesh A, Goodwin J, Okoro E, Guo Z. Overexpression of Catalase Enhances Benzo(a)pyrene Detoxification in Endothelial Microsomes. PLoS ONE. 2016;11:e0162561 pubmed publisher
    We previously reported that overexpression of catalase upregulated xenobiotic- metabolizing enzyme (XME) expression and diminished benzo(a)pyrene (BaP) intermediate accumulation in mouse aortic endothelial cells (MAECs)...
  86. Yamada K, Ito A, Watanabe H, Takahashi T, Basaran N, Gotoh T. High sensitivity to hepato-tumorigenesis in hypocatalasemic C3H/C(s)b/Gen mice exposed to low doses of 252Cf fission neutrons and 60Co gamma-rays. Anticancer Res. 1997;17:2041-7 pubmed
    ..The glutathione peroxidase activity in the liver of the male was higher in C(s)b than that in C3H although catalase activity in C(s)b was lower than that in C3H...