Casr

Summary

Gene Symbol: Casr
Description: calcium-sensing receptor
Alias: CaR, Gprc2a, extracellular calcium-sensing receptor, G protein-coupled receptor, family C, group 2, member A, PCaR1, cation sensing receptor, parathyroid cell calcium-sensing receptor
Species: mouse
Products:     Casr

Top Publications

  1. VanHouten J, Neville M, Wysolmerski J. The calcium-sensing receptor regulates plasma membrane calcium adenosine triphosphatase isoform 2 activity in mammary epithelial cells: a mechanism for calcium-regulated calcium transport into milk. Endocrinology. 2007;148:5943-54 pubmed
    The calcium-sensing receptor (CaR) regulates transepithelial calcium transport into milk by mammary epithelial cells...
  2. Kos C, Karaplis A, Peng J, Hediger M, Goltzman D, Mohammad K, et al. The calcium-sensing receptor is required for normal calcium homeostasis independent of parathyroid hormone. J Clin Invest. 2003;111:1021-8 pubmed
    The extracellular calcium-sensing receptor (CaR; alternate gene names, CaR or Casr) is a membrane-spanning G protein-coupled receptor. CaR is highly expressed in the parathyroid gland, and is activated by extracellular calcium (Ca(2+)(o))...
  3. Mentaverri R, Yano S, Chattopadhyay N, Petit L, Kifor O, Kamel S, et al. The calcium sensing receptor is directly involved in both osteoclast differentiation and apoptosis. FASEB J. 2006;20:2562-4 pubmed
    Intracellular transduction pathways that are dependent on activation of the CaR by Ca(o)2+ have been studied extensively in parathyroid and other cell types, and include cytosolic calcium, phospholipases C, A2, and D, protein kinase C ..
  4. Lee G, Subramanian N, Kim A, Aksentijevich I, Goldbach Mansky R, Sacks D, et al. The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP. Nature. 2012;492:123-7 pubmed publisher
    ..Here we show that the murine calcium-sensing receptor (CASR) activates the NLRP3 inflammasome, mediated by increased intracellular Ca(2+) and decreased cellular cyclic AMP (..
  5. Shu L, Ji J, Zhu Q, Cao G, Karaplis A, Pollak M, et al. The calcium-sensing receptor mediates bone turnover induced by dietary calcium and parathyroid hormone in neonates. J Bone Miner Res. 2011;26:1057-71 pubmed publisher
    We have investigated, in neonates, whether the calcium-sensing receptor (CaR) mediates the effects of dietary calcium on bone turnover and/or modulates parathyroid hormone (PTH)-induced bone turnover...
  6. Rey O, Chang W, Bikle D, Rozengurt N, Young S, Rozengurt E. Negative cross-talk between calcium-sensing receptor and ?-catenin signaling systems in colonic epithelium. J Biol Chem. 2012;287:1158-67 pubmed publisher
    Here, we examined the role of the extracellular Ca(2+)-sensing receptor (CaSR) in the control of colonic epithelial cell proliferation in vivo and changes in ?-catenin triggered by CaSR stimulation in human colonic epithelial cells in ..
  7. Kovacs C, Manley N, Moseley J, Martin T, Kronenberg H. Fetal parathyroids are not required to maintain placental calcium transport. J Clin Invest. 2001;107:1007-15 pubmed
    ..The findings in the Pthr1-null fetuses indicate that several tissues may contribute to the circulating PTHrP level in fetal mice. ..
  8. Oda Y, Tu C, Chang W, Crumrine D, Komuves L, Mauro T, et al. The calcium sensing receptor and its alternatively spliced form in murine epidermal differentiation. J Biol Chem. 2000;275:1183-90 pubmed
    We have recently reported that human keratinocytes express both the full-length calcium sensing receptor (CaR) and an alternatively spliced form lacking exon 5, which were suggested to be involved in calcium induced keratinocyte ..
  9. Turksen K, Troy T. Overexpression of the calcium sensing receptor accelerates epidermal differentiation and permeability barrier formation in vivo. Mech Dev. 2003;120:733-44 pubmed
    The calcium sensing receptor (CaSR) has emerged as an important mediator of a wide range of Ca(2+)-dependent physiological responses (Ca(2+) signaling) in various tissues...

More Information

Publications82

  1. Komuves L, Oda Y, Tu C, Chang W, Ho Pao C, Mauro T, et al. Epidermal expression of the full-length extracellular calcium-sensing receptor is required for normal keratinocyte differentiation. J Cell Physiol. 2002;192:45-54 pubmed
    ..We then evaluated the changes in epidermal keratinocyte morphology and differentiation in Casr(-/-) mice lacking the full-length CaR...
  2. Quinn S, Thomsen A, Pang J, Kantham L, Brauner Osborne H, Pollak M, et al. Interactions between calcium and phosphorus in the regulation of the production of fibroblast growth factor 23 in vivo. Am J Physiol Endocrinol Metab. 2013;304:E310-20 pubmed publisher
    ..using genetic mouse models with targeted inactivation of PTH (PTH KO) or both PTH and the calcium-sensing receptor (CaSR; PTH-CaSR DKO)...
  3. Garner S, Pi M, Tu Q, Quarles L. Rickets in cation-sensing receptor-deficient mice: an unexpected skeletal phenotype. Endocrinology. 2001;142:3996-4005 pubmed
    ..in regulating osteoblast, osteoclast, and cartilage function through the extracellular cation-sensing receptor, CasR, is gaining widespread support, but lacks definite proof...
  4. Chang W, Tu C, Chen T, Komuves L, Oda Y, Pratt S, et al. Expression and signal transduction of calcium-sensing receptors in cartilage and bone. Endocrinology. 1999;140:5883-93 pubmed
    ..and bone by in situ hybridization, immunocytochemistry, immunoblotting, and RT-PCR; and we tested the effects of CaR agonists on signal transduction in chondrogenic and osteogenic cell lines...
  5. VanHouten J, Dann P, McGeoch G, Brown E, Krapcho K, Neville M, et al. The calcium-sensing receptor regulates mammary gland parathyroid hormone-related protein production and calcium transport. J Clin Invest. 2004;113:598-608 pubmed
    ..in mammary epithelial cells are regulated by extracellular calcium acting through the calcium-sensing receptor (CaR). The CaR becomes expressed on mammary epithelial cells at the transition from pregnancy to lactation...
  6. Yamauchi M, Yamaguchi T, Kaji H, Sugimoto T, Chihara K. Involvement of calcium-sensing receptor in osteoblastic differentiation of mouse MC3T3-E1 cells. Am J Physiol Endocrinol Metab. 2005;288:E608-16 pubmed
    We have previously shown that the extracellular calcium-sensing receptor (CaR) is expressed in various bone marrow-derived cell lines and plays an important role in stimulating their proliferation and chemotaxis...
  7. Rodriguez L, Tu C, Cheng Z, Chen T, Bikle D, Shoback D, et al. Expression and functional assessment of an alternatively spliced extracellular Ca2+-sensing receptor in growth plate chondrocytes. Endocrinology. 2005;146:5294-303 pubmed
    The extracellular Ca(2+)-sensing receptor (CaR) plays an essential role in mineral homeostasis...
  8. Adams G, Chabner K, Alley I, Olson D, Szczepiorkowski Z, Poznansky M, et al. Stem cell engraftment at the endosteal niche is specified by the calcium-sensing receptor. Nature. 2006;439:599-603 pubmed
    ..to extracellular ionic calcium concentrations through the seven-transmembrane-spanning calcium-sensing receptor (CaR), which we identified as being expressed on HSCs...
  9. Tu Q, Pi M, Karsenty G, Simpson L, Liu S, Quarles L. Rescue of the skeletal phenotype in CasR-deficient mice by transfer onto the Gcm2 null background. J Clin Invest. 2003;111:1029-37 pubmed
    To understand the role of the calcium-sensing receptor (CasR) in the skeleton, we used a genetic approach to ablate parathyroid glands and remove the confounding effects of elevated parathyroid hormone (PTH) in CasR-deficient mice...
  10. Tu C, Chang W, Xie Z, Bikle D. Inactivation of the calcium sensing receptor inhibits E-cadherin-mediated cell-cell adhesion and calcium-induced differentiation in human epidermal keratinocytes. J Biol Chem. 2008;283:3519-28 pubmed
    ..Inactivation of the endogenous CaR-encoding gene CASR by adenoviral expression of a CaR antisense cDNA inhibited the Ca(2+)(o)-induced increase in intracellular free ..
  11. Chang W, Tu C, Chen T, Bikle D, Shoback D. The extracellular calcium-sensing receptor (CaSR) is a critical modulator of skeletal development. Sci Signal. 2008;1:ra1 pubmed publisher
    The extracellular Ca(2+)-sensing receptor (CaSR) plays a nonredundant role in the functions of the parathyroid gland (PTG) and the kidney...
  12. Kovacs C, Ho Pao C, Hunzelman J, Lanske B, Fox J, Seidman J, et al. Regulation of murine fetal-placental calcium metabolism by the calcium-sensing receptor. J Clin Invest. 1998;101:2812-20 pubmed
    The calcium-sensing receptor (CaSR) regulates PTH secretion to control the extracellular calcium concentration in adults, but its role in fetal life is unknown...
  13. Macleod R. Extracellular calcium-sensing receptor/PTH knockout mice colons have increased Wnt/?-catenin signaling, reduced non-canonical Wnt signaling, and increased susceptibility to azoxymethane-induced aberrant crypt foci. Lab Invest. 2013;93:520-7 pubmed publisher
    ..To understand a role of the colonic extracellular calcium-sensing receptor (CaSR) in calcium-mediated chemoprevention of colon cancer, we induced formation of aberrant crypt foci (ACF) caused by ..
  14. Ho C, Conner D, Pollak M, Ladd D, Kifor O, Warren H, et al. A mouse model of human familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism. Nat Genet. 1995;11:389-94 pubmed
    Mice lacking the calcium-sensing receptor (Casr) were created to examine the receptor's role in calcium homeostasis and to elucidate the mechanism by which inherited human Casr gene defects cause diseases...
  15. Pollak M, Brown E, Chou Y, Hebert S, Marx S, Steinmann B, et al. Mutations in the human Ca(2+)-sensing receptor gene cause familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism. Cell. 1993;75:1297-303 pubmed
    ..We conclude that the mammalian Ca(2+)-sensing receptor "sets" the extracellular Ca2+ level and is defective in individuals with FHH and NSHPT. ..
  16. Yamaguchi T, Chattopadhyay N, Kifor O, Brown E. Extracellular calcium (Ca2+(o))-sensing receptor in a murine bone marrow-derived stromal cell line (ST2): potential mediator of the actions of Ca2+(o) on the function of ST2 cells. Endocrinology. 1998;139:3561-8 pubmed
    The calcium-sensing receptor (CaR) is a G protein-coupled receptor that plays key roles in extracellular calcium ion (Ca2+(o)) homeostasis by mediating the actions of Ca2+(o) on parathyroid gland and kidney...
  17. Hough T, Bogani D, Cheeseman M, Favor J, Nesbit M, Thakker R, et al. Activating calcium-sensing receptor mutation in the mouse is associated with cataracts and ectopic calcification. Proc Natl Acad Sci U S A. 2004;101:13566-71 pubmed
    ..mapping studies located the locus to chromosome 16, in the vicinity of the CaSR gene (Mouse Genome Database symbol Gprc2a). DNA sequence analysis revealed the presence of a Gprc2a missense mutation, Leu723Gln...
  18. Sun W, Sun W, Liu J, Zhou X, Xiao Y, Karaplis A, et al. Alterations in phosphorus, calcium and PTHrP contribute to defects in dental and dental alveolar bone formation in calcium-sensing receptor-deficient mice. Development. 2010;137:985-92 pubmed publisher
    To determine whether the calcium-sensing receptor (CaR) participates in tooth formation and dental alveolar bone development in mandibles in vivo, we examined these processes, as well as mineralization, in 2-week-old CaR-knockout (CaR(-/-..
  19. Rossol M, Pierer M, Raulien N, Quandt D, Meusch U, Rothe K, et al. Extracellular Ca2+ is a danger signal activating the NLRP3 inflammasome through G protein-coupled calcium sensing receptors. Nat Commun. 2012;3:1329 pubmed publisher
    ..Our results demonstrate that G-protein-coupled receptors can activate the inflammasome, and indicate that increased extracellular calcium has a role as a danger signal and amplifier of inflammation. ..
  20. Ye C, Ho Pao C, Kanazirska M, Quinn S, Seidman C, Seidman J, et al. Deficient cation channel regulation in neurons from mice with targeted disruption of the extracellular Ca2+-sensing receptor gene. Brain Res Bull. 1997;44:75-84 pubmed
    This study presents evidence that a receptor sensitive to the concentration of extracellular Ca2+ (Ca[2+]o) (CaR) is functionally coupled to ion channels involved in modulation of neuronal excitability...
  21. Liu J, Lv F, Sun W, Tao C, Ding G, Karaplis A, et al. The abnormal phenotypes of cartilage and bone in calcium-sensing receptor deficient mice are dependent on the actions of calcium, phosphorus, and PTH. PLoS Genet. 2011;7:e1002294 pubmed publisher
    Patients with neonatal severe hyperparathyroidism (NSHPT) are homozygous for the calcium-sensing receptor (CaR) mutation and have very high circulating PTH, abundant parathyroid hyperplasia, and severe life-threatening hypercalcemia...
  22. Tu C, Crumrine D, Man M, Chang W, Elalieh H, You M, et al. Ablation of the calcium-sensing receptor in keratinocytes impairs epidermal differentiation and barrier function. J Invest Dermatol. 2012;132:2350-2359 pubmed publisher
    The calcium-sensing receptor (CaR) has an essential role in mediating Ca(2+)-induced keratinocyte differentiation in vitro...
  23. Mamillapalli R, VanHouten J, Dann P, Bikle D, Chang W, Brown E, et al. Mammary-specific ablation of the calcium-sensing receptor during lactation alters maternal calcium metabolism, milk calcium transport, and neonatal calcium accrual. Endocrinology. 2013;154:3031-42 pubmed publisher
    ..Previous data have suggested that, during lactation, the breast relies on the calcium-sensing receptor (CaSR) to coordinate PTHrP secretion and milk calcium transport with calcium availability...
  24. Sun X, Stephens L, Dubose T, Petrovic S. Adaptation by the collecting duct to an exogenous acid load is blunted by deletion of the proton-sensing receptor GPR4. Am J Physiol Renal Physiol. 2015;309:F120-36 pubmed publisher
    ..Indeed, the expression of the calcium-sensing receptor (CaSR) was nearly doubled in GPR4-/- kidneys, in the absence of apparent disturbances of Ca(2+) homeostasis...
  25. Tang H, Yamamura A, Yamamura H, Song S, Fraidenburg D, Chen J, et al. Pathogenic role of calcium-sensing receptors in the development and progression of pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2016;310:L846-59 pubmed publisher
    ..Previously, we demonstrated that expression and function of calcium sensing receptors (CaSR) in PASMC from patients with idiopathic pulmonary arterial hypertension (IPAH) and animals with experimental ..
  26. Babinsky V, Hannan F, Ramracheya R, Zhang Q, Nesbit M, Hugill A, et al. Mutant Mice With Calcium-Sensing Receptor Activation Have Hyperglycemia That Is Rectified by Calcilytic Therapy. Endocrinology. 2017;158:2486-2502 pubmed publisher
    The calcium-sensing receptor (CaSR) is a family C G-protein-coupled receptor that plays a pivotal role in extracellular calcium homeostasis...
  27. Janicic N, Soliman E, Pausova Z, Seldin M, Riviere M, Szpirer J, et al. Mapping of the calcium-sensing receptor gene (CASR) to human chromosome 3q13.3-21 by fluorescence in situ hybridization, and localization to rat chromosome 11 and mouse chromosome 16. Mamm Genome. 1995;6:798-801 pubmed
    The calcium-sensing receptor (CASR), a member of the G-protein coupled receptor family, is expressed in both parathyroid and kidney, and aids these organs in sensing extracellular calcium levels...
  28. Cheng Z, Tu C, Rodriguez L, Chen T, Dvorak M, Margeta M, et al. Type B gamma-aminobutyric acid receptors modulate the function of the extracellular Ca2+-sensing receptor and cell differentiation in murine growth plate chondrocytes. Endocrinology. 2007;148:4984-92 pubmed
    ..immunocytochemistry and whether interactions between these receptors influence the expression and function of the CaR and extracellular Ca(2+)-mediated cell differentiation...
  29. Pi M, Quarles L. Osteoblast calcium-sensing receptor has characteristics of ANF/7TM receptors. J Cell Biochem. 2005;95:1081-92 pubmed
    ..Candidates are CASR and a putative novel calcium-sensing receptor, called Ob.CASR. To further characterize Ob...
  30. Feng J, Petersen C, Coy D, Jiang J, Thomas C, Pollak M, et al. Calcium-sensing receptor is a physiologic multimodal chemosensor regulating gastric G-cell growth and gastrin secretion. Proc Natl Acad Sci U S A. 2010;107:17791-6 pubmed publisher
    The calcium-sensing receptor (CaR) is the major sensor and regulator of extracellular Ca(2+), whose activity is allosterically regulated by amino acids and pH...
  31. Kantham L, Quinn S, Egbuna O, Baxi K, Butters R, Pang J, et al. The calcium-sensing receptor (CaSR) defends against hypercalcemia independently of its regulation of parathyroid hormone secretion. Am J Physiol Endocrinol Metab. 2009;297:E915-23 pubmed publisher
    The calcium-sensing receptor (CaSR) controls parathyroid hormone (PTH) secretion, which, in turn, via direct and indirect actions on kidney, bone, and intestine, maintains a normal extracellular ionized calcium concentration (Ca(2+)(o))...
  32. Ortiz Capisano M, Ortiz P, Garvin J, Harding P, Beierwaltes W. Expression and function of the calcium-sensing receptor in juxtaglomerular cells. Hypertension. 2007;50:737-43 pubmed
    ..We conclude that juxtaglomerular cells express the calcium-sensing receptor and that their activation leads to inhibition of adenylyl cyclase-V activity, decreasing cAMP formation and suppressing renin release. ..
  33. Quarles L, Hartle J, Siddhanti S, Guo R, Hinson T. A distinct cation-sensing mechanism in MC3T3-E1 osteoblasts functionally related to the calcium receptor. J Bone Miner Res. 1997;12:393-402 pubmed
    ..extracellular cations stimulate osteoblasts through the recently identified G protein-coupled calcium receptor (CaR)...
  34. Vassilev P, Ho Pao C, Kanazirska M, Ye C, Hong K, Seidman C, et al. Cao-sensing receptor (CaR)-mediated activation of K+ channels is blunted in CaR gene-deficient mouse neurons. Neuroreport. 1997;8:1411-6 pubmed
    The extracellular Ca2+ (Cao)-sensing receptor (CaR) is expressed in hippocampus and other brain regions, suggesting that it could mediate some of the well recognized but poorly understood direct actions of Cao on neuronal function...
  35. Yamamura A, Guo Q, Yamamura H, Zimnicka A, Pohl N, Smith K, et al. Enhanced Ca(2+)-sensing receptor function in idiopathic pulmonary arterial hypertension. Circ Res. 2012;111:469-81 pubmed publisher
    ..We examined whether the extracellular Ca(2+)-sensing receptor (CaSR) is involved in the enhanced Ca(2+) influx and proliferation in IPAH-PASMC and whether blockade of CaSR inhibits ..
  36. Fudge N, Kovacs C. Physiological studies in heterozygous calcium sensing receptor (CaSR) gene-ablated mice confirm that the CaSR regulates calcitonin release in vivo. BMC Physiol. 2004;4:5 pubmed
    The calcium sensing receptor (CaSR) regulates serum calcium by suppressing secretion of parathyroid hormone; it also regulates renal tubular calcium excretion...
  37. Bystrova M, Romanov R, Rogachevskaja O, Churbanov G, Kolesnikov S. Functional expression of the extracellular-Ca2+-sensing receptor in mouse taste cells. J Cell Sci. 2010;123:972-82 pubmed publisher
    ..We demonstrate here the expression of two G-protein-coupled receptors from the family C, CASR and GPRC6A, in the taste tissue and identify transcripts for both receptors in type I cells, no transcripts in type ..
  38. Quinn S, Thomsen A, Egbuna O, Pang J, Baxi K, Goltzman D, et al. CaSR-mediated interactions between calcium and magnesium homeostasis in mice. Am J Physiol Endocrinol Metab. 2013;304:E724-33 pubmed publisher
    ..However, the role of the calcium-sensing receptor (CaSR) in Mg homeostasis in vivo is not well understood...
  39. San Gabriel A, Uneyama H, Maekawa T, Torii K. The calcium-sensing receptor in taste tissue. Biochem Biophys Res Commun. 2009;378:414-8 pubmed publisher
    ..Here, we propose another system for calcium taste involving the extracellular calcium-sensing receptor (CaSR)...
  40. Tang L, Peng M, Liu L, Chang W, Binder H, Cheng S. Calcium-sensing receptor stimulates Cl(-)- and SCFA-dependent but inhibits cAMP-dependent HCO3(-) secretion in colon. Am J Physiol Gastrointest Liver Physiol. 2015;308:G874-83 pubmed publisher
    ..These present studies show that extracellular calcium-sensing receptor (CaSR), a fundamental mechanism for sensing and regulating ionic and nutrient compositions of extracellular milieu in the ..
  41. Kovacs C, Chafe L, Woodland M, McDonald K, Fudge N, Wookey P. Calcitropic gene expression suggests a role for the intraplacental yolk sac in maternal-fetal calcium exchange. Am J Physiol Endocrinol Metab. 2002;282:E721-32 pubmed
    ..These observations indicated that the intraplacental yolk sac contains calcium transfer and calcium-sensing capability and that it is a probable route of maternal-fetal calcium exchange in the mouse. ..
  42. Hannan F, Walls G, Babinsky V, Nesbit M, Kallay E, Hough T, et al. The Calcilytic Agent NPS 2143 Rectifies Hypocalcemia in a Mouse Model With an Activating Calcium-Sensing Receptor (CaSR) Mutation: Relevance to Autosomal Dominant Hypocalcemia Type 1 (ADH1). Endocrinology. 2015;156:3114-21 pubmed publisher
    ..hypocalcemia type 1 (ADH1) is caused by germline gain-of-function mutations of the calcium-sensing receptor (CaSR) and may lead to symptomatic hypocalcemia, inappropriately low serum PTH concentrations and hypercalciuria...
  43. Mamillapalli R, VanHouten J, Zawalich W, Wysolmerski J. Switching of G-protein usage by the calcium-sensing receptor reverses its effect on parathyroid hormone-related protein secretion in normal versus malignant breast cells. J Biol Chem. 2008;283:24435-47 pubmed publisher
    The calcium-sensing receptor (CaR) is a G-protein-coupled receptor that signals in response to extracellular calcium and regulates parathyroid hormone secretion...
  44. Liu Z, Yu S, Manley N. Gcm2 is required for the differentiation and survival of parathyroid precursor cells in the parathyroid/thymus primordia. Dev Biol. 2007;305:333-46 pubmed
    ..common primordium did not express Pth and could not maintain the expression of two other parathyroid marker genes, CasR and CCL21, although expression of these two genes was initiated...
  45. Oh Y, Seo E, Lee Y, Cho S, Jung H, Park S, et al. Increase of Calcium Sensing Receptor Expression Is Related to Compensatory Insulin Secretion during Aging in Mice. PLoS ONE. 2016;11:e0159689 pubmed publisher
    ..were significantly decreased at 12, 20 and 28 months of age compared with 4 months and calcium sensing receptor (CaSR) mRNA expression in the islets significantly increased with age...
  46. Cheng S, Lightfoot Y, Yang T, Zadeh M, Tang L, Sahay B, et al. Epithelial CaSR deficiency alters intestinal integrity and promotes proinflammatory immune responses. FEBS Lett. 2014;588:4158-66 pubmed publisher
    ..Herein, we clarify the role of the extracellular calcium-sensing receptor (CaSR) using intestinal epithelium-specific Casr(-/-) mice...
  47. Ardeshirpour L, Dann P, Pollak M, Wysolmerski J, VanHouten J. The calcium-sensing receptor regulates PTHrP production and calcium transport in the lactating mammary gland. Bone. 2006;38:787-93 pubmed
    ..The calcium-sensing receptor (CaR) is a G-protein-coupled receptor that signals in response to extracellular calcium ions...
  48. Oda Y, Hu L, Nguyen T, Fong C, Tu C, Bikle D. Combined Deletion of the Vitamin D Receptor and Calcium-Sensing Receptor Delays Wound Re-epithelialization. Endocrinology. 2017;158:1929-1938 pubmed publisher
    ..vitamin D and calcium signaling in wound healing by deleting their receptors, Vdr and the calcium-sensing receptor (Casr)...
  49. Ren H, Vallanat B, Nelson D, Yeung L, Guruge K, Lam P, et al. Evidence for the involvement of xenobiotic-responsive nuclear receptors in transcriptional effects upon perfluoroalkyl acid exposure in diverse species. Reprod Toxicol. 2009;27:266-77 pubmed publisher
    ..for transcriptional changes in the mouse liver after PFOA exposure including the constitutive activated receptor (CAR) and pregnane X receptor (PXR) that regulate xenobiotic metabolizing enzymes (XME)...
  50. Grigorieva I, Mirczuk S, Gaynor K, Nesbit M, Grigorieva E, Wei Q, et al. Gata3-deficient mice develop parathyroid abnormalities due to dysregulation of the parathyroid-specific transcription factor Gcm2. J Clin Invest. 2010;120:2144-55 pubmed publisher
    ..Thus, GATA3 is critical for the differentiation and survival of parathyroid progenitor cells and, with GCM2/B, forms part of a transcriptional cascade in parathyroid development and function. ..
  51. Aggarwal A, Prinz Wohlgenannt M, Tennakoon S, Höbaus J, Boudot C, Mentaverri R, et al. The calcium-sensing receptor: A promising target for prevention of colorectal cancer. Biochim Biophys Acta. 2015;1853:2158-67 pubmed publisher
    ..Expression of the calcium-sensing receptor (CaSR), a calcium-binding G protein-coupled receptor is downregulated in CRC leading us to hypothesize that the CaSR has ..
  52. Xue Y, Xiao Y, Liu J, Karaplis A, Pollak M, Brown E, et al. The calcium-sensing receptor complements parathyroid hormone-induced bone turnover in discrete skeletal compartments in mice. Am J Physiol Endocrinol Metab. 2012;302:E841-51 pubmed publisher
    Although the calcium-sensing receptor (CaSR) and parathyroid hormone (PTH) may each exert skeletal effects, it is uncertain how CaSR and PTH interact at the level of bone in primary hyperparathyroidism (PHPT)...
  53. Ranieri M, Tamma G, Di Mise A, Russo A, Centrone M, Svelto M, et al. Negative feedback from CaSR signaling to aquaporin-2 sensitizes vasopressin to extracellular Ca2. J Cell Sci. 2015;128:2350-60 pubmed publisher
    ..short-term vasopressin-induced aquaporin-2 (AQP2) trafficking through activation of the Ca(2+)-sensing receptor (CaSR)...
  54. Richard C, Huo R, Samadfam R, Bolivar I, Miao D, Brown E, et al. The calcium-sensing receptor and 25-hydroxyvitamin D-1alpha-hydroxylase interact to modulate skeletal growth and bone turnover. J Bone Miner Res. 2010;25:1627-36 pubmed publisher
    ..and in mice expressing the null mutation for both the 1alpha(OH)ase and the calcium-sensing receptor [Casr(-/-)1alpha(OH)ase(-/-)] genes...
  55. Geibel J, Sritharan K, Geibel R, Geibel P, Persing J, Seeger A, et al. Calcium-sensing receptor abrogates secretagogue- induced increases in intestinal net fluid secretion by enhancing cyclic nucleotide destruction. Proc Natl Acad Sci U S A. 2006;103:9390-7 pubmed
    The calcium-sensing receptor (CaSR) provides a fundamental mechanism for diverse cells to detect and respond to modulations in the ionic and nutrient compositions of their extracellular milieu...
  56. Hinson T, Damodaran T, Chen J, Zhang X, Qumsiyeh M, Seldin M, et al. Identification of putative transmembrane receptor sequences homologous to the calcium-sensing G-protein-coupled receptor. Genomics. 1997;45:279-89 pubmed
    ..A calcium-sensing receptor (Casr) belonging to the metabotropic glutamate family of G-protein-coupled receptors (GPCR) that transduces the effects ..
  57. House M, Kohlmeier L, Chattopadhyay N, Kifor O, Yamaguchi T, LeBoff M, et al. Expression of an extracellular calcium-sensing receptor in human and mouse bone marrow cells. J Bone Miner Res. 1997;12:1959-70 pubmed
    The cloning of a G protein-coupled, extracellular calcium (Ca2+e)-sensing receptor (CaR) from bovine parathyroid provided direct evidence that Ca2+e-sensing can occur through receptor-mediated activation of G proteins and their ..
  58. Sun J, He W, Bai S, Peng X, Zhang N, Li H, et al. The expression of calcium-sensing receptor in mouse embryonic stem cells (mESCs) and its influence on differentiation of mESC into cardiomyocytes. Differentiation. 2013;85:32-40 pubmed publisher
    The calcium-sensing receptor (CaSR), a G protein coupled receptor, is involved in a number of physiological and pathological processes. Embryonic stem cells (ESCs) have a potential role to differentiate into all types of cells...
  59. Ciriza J, Hall D, Lu A, De Sena J, Al Kuhlani M, Garcia Ojeda M. Single-cell analysis of murine long-term hematopoietic stem cells reveals distinct patterns of gene expression during fetal migration. PLoS ONE. 2012;7:e30542 pubmed publisher
    ..varies across developmental microenvironments and times, while the cadherin Cdh2 (Ncad) and the calcium receptor Casr show higher gene expression and variability only in FBM at 17.5 days post coitum (dpc)...
  60. Kwak J, Kwak J, Kim H, Oh K, Kim Y, Jung S, et al. The extracellular calcium sensing receptor is expressed in mouse mesangial cells and modulates cell proliferation. Exp Mol Med. 2005;37:457-65 pubmed
    The extracellular calcium sensing receptor (CaSR) belongs to the type III family of G-protein-coupled receptors, a family that comprises the metabotropic glutamate receptor and the putative vomeronasal organ receptors...
  61. Sun J, Wei T, Bai S, Zhao H, Liu X, Yu J, et al. Calcium-sensing receptor-mediated mitogen-activated protein kinase pathway improves the status of transplanted mouse embryonic stem cells in rats with acute myocardial infarction. Mol Cell Biochem. 2017;431:151-160 pubmed publisher
    ..Using acute myocardial infarction rat models, we found that a combination therapy of CaSR inhibition and embryonic stem cell (ESC) transplantation after acute myocardial infarction (AMI) leads to a ..
  62. Wei W, Jacobs B, Becker E, Glitsch M. Reciprocal regulation of two G protein-coupled receptors sensing extracellular concentrations of Ca2+ and H. Proc Natl Acad Sci U S A. 2015;112:10738-43 pubmed publisher
    ..Extracellular calcium-sensing receptor (CaSR) and ovarian cancer gene receptor 1 (OGR1) are two GPCRs that sense extracellular Ca(2+) and H(+), respectively...
  63. Vizard T, O Keeffe G, Gutierrez H, Kos C, Riccardi D, Davies A. Regulation of axonal and dendritic growth by the extracellular calcium-sensing receptor. Nat Neurosci. 2008;11:285-91 pubmed publisher
    The extracellular calcium-sensing receptor (CaSR) monitors the systemic, extracellular, free ionized-calcium level ([Ca(2+)](o)) in organs involved in systemic [Ca(2+)](o) homeostasis...
  64. Pi M, Garner S, Flannery P, Spurney R, Quarles L. Sensing of extracellular cations in CasR-deficient osteoblasts. Evidence for a novel cation-sensing mechanism. J Biol Chem. 2000;275:3256-63 pubmed
    We isolated osteoblastic cell lines from wild-type (CasR(+/+)) and receptor null (CasR(-/-)) mice to investigate whether CasR is present in osteoblasts and accounts for their responses to extracellular cations...
  65. Lieben L, Stockmans I, Moermans K, Carmeliet G. Maternal hypervitaminosis D reduces fetal bone mass and mineral acquisition and leads to neonatal lethality. Bone. 2013;57:123-31 pubmed publisher
    ..In conclusion, these data indicate that high maternal 1,25(OH)2D levels are transferred across the placental barrier and adversely affect the total amount of calcium stored in fetal bones which is accompanied by neonatal death. ..
  66. Awumey E, Bridges L, Williams C, Diz D. Nitric-oxide synthase knockout modulates Ca²?-sensing receptor expression and signaling in mouse mesenteric arteries. J Pharmacol Exp Ther. 2013;346:38-47 pubmed publisher
    ..arteries is dependent on an intact perivascular sensory nerve network that expresses the Ca²?-sensing receptor (CaSR)...
  67. Motoyama H, Friedman P. Calcium-sensing receptor regulation of PTH-dependent calcium absorption by mouse cortical ascending limbs. Am J Physiol Renal Physiol. 2002;283:F399-406 pubmed
    ..The Ca(2+)-sensing receptor (CaSR) is expressed on serosal membranes of CALs...
  68. Sabrautzki S, Rubio Aliaga I, Hans W, Fuchs H, Rathkolb B, Calzada Wack J, et al. New mouse models for metabolic bone diseases generated by genome-wide ENU mutagenesis. Mamm Genome. 2012;23:416-30 pubmed publisher
    ..Fifteen mutations among three genes (Phex, Casr, and Alpl) have been identified by positional-candidate gene approaches and one mutation of the Asgr1 gene, which ..
  69. Gong Y, Renigunta V, Himmerkus N, Zhang J, Renigunta A, Bleich M, et al. Claudin-14 regulates renal Ca?? transport in response to CaSR signalling via a novel microRNA pathway. EMBO J. 2012;31:1999-2012 pubmed publisher
    ..The Ca(++) sensing receptor (CaSR) acts upstream of the microRNA-claudin-14 axis...
  70. Dvorak Ewell M, Chen T, Liang N, Garvey C, Liu B, Tu C, et al. Osteoblast extracellular Ca2+ -sensing receptor regulates bone development, mineralization, and turnover. J Bone Miner Res. 2011;26:2935-47 pubmed publisher
    The extracellular Ca(2+) -sensing receptor (CaR), a G protein-coupled receptor responsible for maintenance of calcium homeostasis, is implicated in regulation of skeletal metabolism...
  71. Egbuna O, Quinn S, Kantham L, Butters R, Pang J, Pollak M, et al. The full-length calcium-sensing receptor dampens the calcemic response to 1alpha,25(OH)2 vitamin D3 in vivo independently of parathyroid hormone. Am J Physiol Renal Physiol. 2009;297:F720-8 pubmed publisher
    ..increases serum Ca(2+) concentration in vivo, an action counteracted by activation of the Ca(2+)-sensing receptor (CaSR), which decreases parathyroid hormone (PTH) secretion and increases renal Ca(2+) excretion...
  72. Aslanova U, Morimoto T, Farajov E, Kumagai N, Nishino M, Sugawara N, et al. Chloride-dependent intracellular pH regulation via extracellular calcium-sensing receptor in the medullary thick ascending limb of the mouse kidney. Tohoku J Exp Med. 2006;210:291-300 pubmed
    The extracellular calcium-sensing receptor (CaSR) located in either luminal or basolateral cell membranes of various types of renal tubules including proximal tubules, Henle's loop and collecting ducts has been thought to play a ..
  73. Vyleta N, Smith S. Spontaneous glutamate release is independent of calcium influx and tonically activated by the calcium-sensing receptor. J Neurosci. 2011;31:4593-606 pubmed publisher
    ..Activation of the calcium-sensing receptor (CaSR), a G-protein-coupled receptor present in nerve terminals, by several specific agonists increased spontaneous ..