carnitine palmitoyltransferase 1c

Summary

Gene Symbol: carnitine palmitoyltransferase 1c
Description: carnitine palmitoyltransferase 1c
Alias: 6530437J22Rik, 9630004I06Rik, CPT I-C, CPT IC, CPT1-B, CPTI-B, carnitine O-palmitoyltransferase 1, brain isoform, carnitine O-palmitoyltransferase I, brain isoform, carnitine palmitoyltransferase 1, brain
Species: mouse

Top Publications

  1. Carrasco P, Sahún I, McDonald J, Ramirez S, Jacas J, Gratacós E, et al. Ceramide levels regulated by carnitine palmitoyltransferase 1C control dendritic spine maturation and cognition. J Biol Chem. 2012;287:21224-32 pubmed publisher
    The brain-specific isoform carnitine palmitoyltransferase 1C (CPT1C) has been implicated in the hypothalamic regulation of food intake and energy homeostasis...
  2. Zaugg K, Yao Y, Reilly P, Kannan K, Kiarash R, Mason J, et al. Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress. Genes Dev. 2011;25:1041-51 pubmed publisher
    ..However, other mechanisms mediating metabolic transformation remain undefined. Here we report that carnitine palmitoyltransferase 1C (CPT1C), a brain-specific metabolic enzyme, may participate in metabolic transformation...
  3. Reamy A, Wolfgang M. Carnitine palmitoyltransferase-1c gain-of-function in the brain results in postnatal microencephaly. J Neurochem. 2011;118:388-98 pubmed publisher
    ..These data show that CPT1c can elicit profound effects on brain physiology and total fatty acid profiles, which can be modulated by the nutritional composition of the diet. ..
  4. Dai Y, Wolfgang M, Cha S, Lane M. Localization and effect of ectopic expression of CPT1c in CNS feeding centers. Biochem Biophys Res Commun. 2007;359:469-74 pubmed
  5. Wolfgang M, Cha S, Millington D, Cline G, Shulman G, Suwa A, et al. Brain-specific carnitine palmitoyl-transferase-1c: role in CNS fatty acid metabolism, food intake, and body weight. J Neurochem. 2008;105:1550-9 pubmed publisher
    ..Heterozygous mice display an intermediate phenotype. These findings provide further evidence that CPT1c plays a role in maintaining energy homeostasis, but not through altered fatty acid oxidation. ..
  6. Gao X, Chen W, Kong X, Xu A, Wang Z, Sweeney G, et al. Enhanced susceptibility of Cpt1c knockout mice to glucose intolerance induced by a high-fat diet involves elevated hepatic gluconeogenesis and decreased skeletal muscle glucose uptake. Diabetologia. 2009;52:912-20 pubmed publisher
    ..We identify changes in hepatic and skeletal muscle glucose metabolism as important mechanisms determining the phenotype of Cpt1c KO mice. ..
  7. Gao S, Zhu G, Gao X, Wu D, Carrasco P, Casals N, et al. Important roles of brain-specific carnitine palmitoyltransferase and ceramide metabolism in leptin hypothalamic control of feeding. Proc Natl Acad Sci U S A. 2011;108:9691-6 pubmed publisher
    ..In summary, we provide insights into the important roles of malonyl-CoA, CPT-1c, and ceramide metabolism in leptin's hypothalamic signaling pathways. ..
  8. Wolfgang M, Kurama T, Dai Y, Suwa A, Asaumi M, Matsumoto S, et al. The brain-specific carnitine palmitoyltransferase-1c regulates energy homeostasis. Proc Natl Acad Sci U S A. 2006;103:7282-7 pubmed
    ..These findings indicate that CPT1c is necessary for the regulation of energy homeostasis. ..
  9. Price N, van der Leij F, Jackson V, Corstorphine C, Thomson R, Sorensen A, et al. A novel brain-expressed protein related to carnitine palmitoyltransferase I. Genomics. 2002;80:433-42 pubmed
    ..Thus this new CPT I related protein may be specialized for the metabolism of a distinct class of fatty acids involved in brain function. ..

More Information

Publications19

  1. Lohse I, Reilly P, Zaugg K. The CPT1C 5'UTR contains a repressing upstream open reading frame that is regulated by cellular energy availability and AMPK. PLoS ONE. 2011;6:e21486 pubmed publisher
  2. Lee J, Wolfgang M. Metabolomic profiling reveals a role for CPT1c in neuronal oxidative metabolism. BMC Biochem. 2012;13:23 pubmed publisher
    ..The subtle changes in a broad range of metabolites in vivo indicate that CPT1c does not play a significant or required role in fatty acid oxidation; however, it could play an alternative role in neuronal oxidative metabolism. ..
  3. Ramirez S, Martins L, Jacas J, Carrasco P, Pozo M, Clotet J, et al. Hypothalamic ceramide levels regulated by CPT1C mediate the orexigenic effect of ghrelin. Diabetes. 2013;62:2329-37 pubmed publisher
  4. Yasrebi A, Hsieh A, Mamounis K, Krumm E, Yang J, Magby J, et al. Differential gene regulation of GHSR signaling pathway in the arcuate nucleus and NPY neurons by fasting, diet-induced obesity, and 17β-estradiol. Mol Cell Endocrinol. 2016;422:42-56 pubmed publisher
    ..DIO in females suppressed Agrp and augmented Cpt1c in NPY neurons. In summary, genes involved in GHSR signaling are differentially regulated between the ARC and NPY neurons in a sex-dependent manner. ..
  5. Schwenk J, Harmel N, Brechet A, Zolles G, Berkefeld H, Müller C, et al. High-resolution proteomics unravel architecture and molecular diversity of native AMPA receptor complexes. Neuron. 2012;74:621-33 pubmed publisher
    ..6 and 1 MDa. The additional constituents change the gating properties of AMPARs and provide links to the protein dynamics fundamental for the complex role of AMPARs in formation and operation of glutamatergic synapses. ..
  6. Sanchez Macedo N, Feng J, Faubert B, Chang N, Elia A, Rushing E, et al. Depletion of the novel p53-target gene carnitine palmitoyltransferase 1C delays tumor growth in the neurofibromatosis type I tumor model. Cell Death Differ. 2013;20:659-68 pubmed publisher
    ..Earlier we reported that carnitine palmitoyltransferase 1C (CPT1C), a brain-specific member of a family of mitochondria-associated enzymes that have a central ..
  7. Carrasco P, Jacas J, Sahún I, Muley H, Ramirez S, Puisac B, et al. Carnitine palmitoyltransferase 1C deficiency causes motor impairment and hypoactivity. Behav Brain Res. 2013;256:291-7 pubmed publisher
    b>Carnitine palmitoyltransferase 1c (CPT1C), a brain-specific protein localized in the endoplasmic reticulum of neurons, is expressed in almost all brain regions, but its only known functions to date are involved in the hypothalamic ..
  8. Rinaldi C, Schmidt T, Situ A, Johnson J, Lee P, Chen K, et al. Mutation in CPT1C Associated With Pure Autosomal Dominant Spastic Paraplegia. JAMA Neurol. 2015;72:561-70 pubmed publisher
    ..The association of the CPT1C mutation with changes in lipid droplet biogenesis supports a role for altered lipid-mediated signal transduction in HSP pathogenesis. ..
  9. Fadó R, Soto D, Miñano Molina A, Pozo M, Carrasco P, Yefimenko N, et al. Novel Regulation of the Synthesis of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Subunit GluA1 by Carnitine Palmitoyltransferase 1C (CPT1C) in the Hippocampus. J Biol Chem. 2015;290:25548-60 pubmed publisher
    ..Recent data suggest that one of the constituents of the AMPAR complex is carnitine palmitoyltransferase 1C (CPT1C), a brain-specific isoform located in the endoplasmic reticulum of neurons...
  10. Pozo M, Rodriguez Rodriguez R, Ramirez S, Seoane Collazo P, Lopez M, Serra D, et al. Hypothalamic Regulation of Liver and Muscle Nutrient Partitioning by Brain-Specific Carnitine Palmitoyltransferase 1C in Male Mice. Endocrinology. 2017;158:2226-2238 pubmed publisher
    ..Overall, our data demonstrate that CPT1C in the MBH is necessary for proper hypothalamic sensing of a negative energy balance and fuel partitioning in liver and muscle. ..