Carm1

Summary

Gene Symbol: Carm1
Description: coactivator-associated arginine methyltransferase 1
Alias: Prmt4, histone-arginine methyltransferase CARM1, protein arginine N-methyltransferase 4, protein arginine methyltransferase
Species: mouse
Products:     Carm1

Top Publications

  1. Chumanov R, Kuhn P, Xu W, Burgess R. Expression and purification of full-length mouse CARM1 from transiently transfected HEK293T cells using HaloTag technology. Protein Expr Purif. 2011;76:145-53 pubmed publisher
    Coactivator-associated arginine methyl transferase 1 (CARM1) is a protein arginine methyltransferase (PRMT) family member that functions as a coactivator in androgen and estrogen signaling pathways and plays a role in the progression of ..
  2. Ito T, Yadav N, Lee J, Furumatsu T, Yamashita S, Yoshida K, et al. Arginine methyltransferase CARM1/PRMT4 regulates endochondral ossification. BMC Dev Biol. 2009;9:47 pubmed publisher
    ..Here we report that coactivator-associated arginine methyltransferase 1 (CARM1) regulates chondrocyte proliferation via arginine methylation of Sox9...
  3. Hassa P, Covic M, Bedford M, Hottiger M. Protein arginine methyltransferase 1 coactivates NF-kappaB-dependent gene expression synergistically with CARM1 and PARP1. J Mol Biol. 2008;377:668-78 pubmed publisher
    ..Here, we show that protein arginine methyltransferase 1 (PRMT1) synergistically coactivates NF-kappaB-dependent gene expression at the macrophage ..
  4. Cheung W, Sakabe K, Housley M, Dias W, Hart G. O-linked beta-N-acetylglucosaminyltransferase substrate specificity is regulated by myosin phosphatase targeting and other interacting proteins. J Biol Chem. 2008;283:33935-41 pubmed publisher
    ..We demonstrate here that MYPT1 and CARM1 also interact with and target OGT. MYPT1 and CARM1 are substrates of OGT in vitro and in vivo...
  5. Ma H, Baumann C, Li H, Strahl B, Rice R, Jelinek M, et al. Hormone-dependent, CARM1-directed, arginine-specific methylation of histone H3 on a steroid-regulated promoter. Curr Biol. 2001;11:1981-5 pubmed
    ..The coactivator CARM1 methylates histone H3 at Arg17 and Arg26 in vitro and cooperates synergistically with p160-type coactivators (e.g...
  6. Li H, Park S, Kilburn B, Jelinek M, Henschen Edman A, Aswad D, et al. Lipopolysaccharide-induced methylation of HuR, an mRNA-stabilizing protein, by CARM1. Coactivator-associated arginine methyltransferase. J Biol Chem. 2002;277:44623-30 pubmed
    ..Instead, HuR is specifically methylated by coactivator-associated arginine methyltransferase 1 (CARM1), a protein-arginine methyltransferase previously shown to serve as a transcriptional coactivator...
  7. Bauer U, Daujat S, Nielsen S, Nightingale K, Kouzarides T. Methylation at arginine 17 of histone H3 is linked to gene activation. EMBO Rep. 2002;3:39-44 pubmed
    The nuclear hormone receptor co-activator CARM1 has the potential to methylate histone H3 at arginine residues in vitro. The methyltransferase activity of CARM1 is necessary for its co-activator functions in transient transfection assays...
  8. Sims R, Rojas L, Beck D, Bonasio R, Schüller R, Drury W, et al. The C-terminal domain of RNA polymerase II is modified by site-specific methylation. Science. 2011;332:99-103 pubmed publisher
    ..of RNAPII is methylated at a single arginine (R1810) by the coactivator-associated arginine methyltransferase 1 (CARM1)...
  9. Covic M, Hassa P, Saccani S, Buerki C, Meier N, Lombardi C, et al. Arginine methyltransferase CARM1 is a promoter-specific regulator of NF-kappaB-dependent gene expression. EMBO J. 2005;24:85-96 pubmed
    ..Here, we show that coactivator-associated arginine methyltransferase CARM1/PRMT4 is a novel transcriptional coactivator of NF-kappaB and functions as a promoter-specific regulator of NF-..

More Information

Publications66

  1. An W, Kim J, Roeder R. Ordered cooperative functions of PRMT1, p300, and CARM1 in transcriptional activation by p53. Cell. 2004;117:735-48 pubmed
    ..and (co)activators to demonstrate (1) the additional involvement of protein arginine methyltransferases PRMT1 and CARM1 in p53 function; (2) both independent and ordered cooperative functions of p300, PRMT1, and CARM1; and (3) ..
  2. Schurter B, Koh S, Chen D, Bunick G, Harp J, Hanson B, et al. Methylation of histone H3 by coactivator-associated arginine methyltransferase 1. Biochemistry. 2001;40:5747-56 pubmed
    ..H3 was at least 1000 times that toward R1 (GGFGGRGGFGG-amide), a highly effective substrate for protein arginine methyltransferase 1...
  3. Chen D, Ma H, Hong H, Koh S, Huang S, Schurter B, et al. Regulation of transcription by a protein methyltransferase. Science. 1999;284:2174-7 pubmed
    ..Coactivator-associated arginine methyltransferase 1 (CARM1), a previously unidentified protein that binds to the carboxyl-terminal region of p160 coactivators, enhanced ..
  4. Kim D, Lee J, Cheng D, Li J, Carter C, Richie E, et al. Enzymatic activity is required for the in vivo functions of CARM1. J Biol Chem. 2010;285:1147-52 pubmed publisher
    ..the importance of CARM1 enzymatic activity in vivo, we generated an enzyme-dead knock-in of this protein arginine methyltransferase. We determined that knock-in cells and mice have defects similar to those seen in their knock-out ..
  5. Lee Y, Koh S, Zhang X, Cheng X, Stallcup M. Synergy among nuclear receptor coactivators: selective requirement for protein methyltransferase and acetyltransferase activities. Mol Cell Biol. 2002;22:3621-32 pubmed
    ..Other members of the protein arginine methyltransferase family, which methylate different protein substrates than CARM1, could not substitute for CARM1 to ..
  6. Feng Q, He B, Jung S, Song Y, Qin J, Tsai S, et al. Biochemical control of CARM1 enzymatic activity by phosphorylation. J Biol Chem. 2009;284:36167-74 pubmed publisher
    ..function is regulated by phosphorylation at Ser(217), a residue completely conserved in the type I protein arginine methyltransferase (PRMT) family of enzymes...
  7. Wu Q, Bruce A, Jedrusik A, Ellis P, Andrews R, Langford C, et al. CARM1 is required in embryonic stem cells to maintain pluripotency and resist differentiation. Stem Cells. 2009;27:2637-2645 pubmed publisher
    ..histone H3 methylation, through expression of coactivator-associated-protein-arginine-methyltransferase 1 (CARM1) in embryos, elevates expression of key pluripotency genes and directs cells to the pluripotent inner cell mass...
  8. Teyssier C, Chen D, Stallcup M. Requirement for multiple domains of the protein arginine methyltransferase CARM1 in its transcriptional coactivator function. J Biol Chem. 2002;277:46066-72 pubmed
    ..activities all reside in the central region of CARM1, which is highly conserved among the entire protein arginine methyltransferase family...
  9. Jayne S, Rothgiesser K, Hottiger M. CARM1 but not its enzymatic activity is required for transcriptional coactivation of NF-kappaB-dependent gene expression. J Mol Biol. 2009;394:485-95 pubmed publisher
    Coactivator-associated arginine methyltransferase 1 (CARM1) belongs to the protein arginine methyltransferase family...
  10. Troffer Charlier N, Cura V, Hassenboehler P, Moras D, Cavarelli J. Functional insights from structures of coactivator-associated arginine methyltransferase 1 domains. EMBO J. 2007;26:4391-401 pubmed
    Coactivator-associated arginine methyltransferase 1 (CARM1), a protein arginine methyltransferase recruited by several transcription factors, methylates a large variety of proteins and plays a critical role in gene expression...
  11. Daujat S, Bauer U, Shah V, Turner B, Berger S, Kouzarides T. Crosstalk between CARM1 methylation and CBP acetylation on histone H3. Curr Biol. 2002;12:2090-7 pubmed
    ..The CBP/p300 acetylase and the CARM1 methyltransferase can positively regulate the expression of estrogen-responsive genes, but the existence of a ..
  12. Fujiwara T, Mori Y, Chu D, Koyama Y, Miyata S, Tanaka H, et al. CARM1 regulates proliferation of PC12 cells by methylating HuD. Mol Cell Biol. 2006;26:2273-85 pubmed
    ..we show a novel mechanism of arginine methylation of HuD by coactivator-associated arginine methyltransferase 1 (CARM1) that affected mRNA turnover of p21cip1/waf1 mRNA in PC12 cells...
  13. Yadav N, Lee J, Kim J, Shen J, Hu M, Aldaz C, et al. Specific protein methylation defects and gene expression perturbations in coactivator-associated arginine methyltransferase 1-deficient mice. Proc Natl Acad Sci U S A. 2003;100:6464-8 pubmed
    ..The coactivator-associated arginine methyltransferase 1 (CARM1/PRMT4) binds the p160 family of steroid receptor coactivators (SRCs)...
  14. Yadav N, Cheng D, Richard S, Morel M, Iyer V, Aldaz C, et al. CARM1 promotes adipocyte differentiation by coactivating PPARgamma. EMBO Rep. 2008;9:193-8 pubmed publisher
    The coactivator-associated arginine methyltransferase 1 (CARM1) is recruited to gene promoters by many transcription factors...
  15. Kim J, Lee J, Yadav N, Wu Q, Carter C, Richard S, et al. Loss of CARM1 results in hypomethylation of thymocyte cyclic AMP-regulated phosphoprotein and deregulated early T cell development. J Biol Chem. 2004;279:25339-44 pubmed
    The coactivator-associated arginine methyltransferase, CARM1, is a positive regulator of transcription. Using high density protein arrays, we have previously identified in vitro substrates for CARM1...
  16. Higashimoto K, Kuhn P, Desai D, Cheng X, Xu W. Phosphorylation-mediated inactivation of coactivator-associated arginine methyltransferase 1. Proc Natl Acad Sci U S A. 2007;104:12318-23 pubmed
    ..Our results provide an example for the regulation of protein arginine methyltransferase activity by phosphorylation...
  17. Xu W, Chen H, Du K, Asahara H, Tini M, Emerson B, et al. A transcriptional switch mediated by cofactor methylation. Science. 2001;294:2507-11 pubmed
    ..Methylation of KIX by coactivator-associated arginine methyltransferase 1 (CARM1) blocks CREB activation by disabling the interaction between KIX and the kinase inducible domain (KID) of CREB...
  18. Dacwag C, Bedford M, SIF S, Imbalzano A. Distinct protein arginine methyltransferases promote ATP-dependent chromatin remodeling function at different stages of skeletal muscle differentiation. Mol Cell Biol. 2009;29:1909-21 pubmed publisher
    ..Here we investigated the requirement for Prmt5 and the class I arginine methyltransferase Carm1/Prmt4 in the temporal control of myogenesis...
  19. Lee J, Bedford M. PABP1 identified as an arginine methyltransferase substrate using high-density protein arrays. EMBO Rep. 2002;3:268-73 pubmed
    The arginine methyltransferases CARM1 and PRMT1 associate with the p160 family of nuclear hormone receptor coactivators. This association enhances transcriptional activation by nuclear receptors...
  20. Yue W, Hassler M, Roe S, Thompson Vale V, Pearl L. Insights into histone code syntax from structural and biochemical studies of CARM1 methyltransferase. EMBO J. 2007;26:4402-12 pubmed
    ..CARM1 contains a conserved protein arginine methyltransferase (PRMT) catalytic core flanked by unique pre- and post-core regions...
  21. Torres Padilla M, Parfitt D, Kouzarides T, Zernicka Goetz M. Histone arginine methylation regulates pluripotency in the early mouse embryo. Nature. 2007;445:214-8 pubmed
    ..We confirm this prediction by overexpressing the H3-specific arginine methyltransferase CARM1 in individual blastomeres and show that this directs their progeny to the ICM and results in a dramatic ..
  22. Cheng D, Cote J, Shaaban S, Bedford M. The arginine methyltransferase CARM1 regulates the coupling of transcription and mRNA processing. Mol Cell. 2007;25:71-83 pubmed
    The coactivator-associated arginine methyltransferase CARM1 is recruited by many different transcription factors as a positive regulator. To understand the mechanism by which CARM1 functions, we sought to isolate its substrates...
  23. Wang L, Zhao Z, Meyer M, Saha S, Yu M, Guo A, et al. CARM1 methylates chromatin remodeling factor BAF155 to enhance tumor progression and metastasis. Cancer Cell. 2014;25:21-36 pubmed publisher
    Coactivator-associated arginine methyltransferase 1 (CARM1), a coactivator for various cancer-relevant transcription factors, is overexpressed in breast cancer...
  24. Wu J, Cui N, Wang R, Li J, Wong J. A role for CARM1-mediated histone H3 arginine methylation in protecting histone acetylation by releasing corepressors from chromatin. PLoS ONE. 2012;7:e34692 pubmed publisher
    ..to identify effector(s) recognizing asymmetrically methylated R17 and R26 in H3, which are catalyzed by CARM1/PRMT4, through an unbiased biochemical approach...
  25. Kowenz Leutz E, Pless O, Dittmar G, Knoblich M, Leutz A. Crosstalk between C/EBPbeta phosphorylation, arginine methylation, and SWI/SNF/Mediator implies an indexing transcription factor code. EMBO J. 2010;29:1105-15 pubmed publisher
    ..The protein arginine methyltransferase 4 PRMT4/CARM1 interacts with C/EBPbeta and dimethylates a conserved arginine residue (R3) in the C/..
  26. Lee Y, Campbell H, Stallcup M. Developmentally essential protein flightless I is a nuclear receptor coactivator with actin binding activity. Mol Cell Biol. 2004;24:2103-17 pubmed
    ..Fli-I bound poorly to and did not cooperate with PRMT1, a CARM1-related protein arginine methyltransferase that also functions as an NR coactivator...
  27. Kim J, Li H, Stallcup M. CoCoA, a nuclear receptor coactivator which acts through an N-terminal activation domain of p160 coactivators. Mol Cell. 2003;12:1537-49 pubmed
    ..secondary coactivators such as the histone acetyltransferases p300 and CBP and the protein methyltransferase CARM1. The function of the highly conserved N-terminal basic-helix-loop-helix/Per-Arnt-Sim (bHLH-PAS) domain of p160 ..
  28. Wu Z, Yang M, Liu H, Guo H, Wang Y, Cheng H, et al. Role of nuclear receptor coactivator 3 (Ncoa3) in pluripotency maintenance. J Biol Chem. 2012;287:38295-304 pubmed publisher
    ..the Nanog promoter and recruits the histone acetyltransferase CREB binding protein (CBP) and the histone arginine methyltransferase CARM1 to activate Nanog expression...
  29. Sanchez G, Dury A, Murray L, Biondi O, Tadesse H, El Fatimy R, et al. A novel function for the survival motoneuron protein as a translational regulator. Hum Mol Genet. 2013;22:668-84 pubmed publisher
    ..We further identify the arginine methyltransferase CARM1 as an mRNA that is regulated at the translational level by SMN and find that CARM1 is abnormally up-regulated in ..
  30. Fronz K, Otto S, Kölbel K, Kuhn U, Friedrich H, Schierhorn A, et al. Promiscuous modification of the nuclear poly(A)-binding protein by multiple protein-arginine methyltransferases does not affect the aggregation behavior. J Biol Chem. 2008;283:20408-20 pubmed publisher
    ..Thus, arginine methylation might be relevant for oculopharyngeal muscular dystrophy. However, in two different types of assays we have been unable to detect any effect of arginine methylation on the aggregation of bovine PABPN1. ..
  31. Li X, Lai Y, Li J, Zou M, Zou C. Oxidative stress destabilizes protein arginine methyltransferase 4 via glycogen synthase kinase 3? to impede lung epithelial cell migration. Am J Physiol Cell Physiol. 2017;313:C285-C294 pubmed publisher
    ..b>Protein arginine methyltransferase 4 (PRMT4) is critical for normal lung alveolar epithelial cell development; however, the regulation ..
  32. Naeem H, Cheng D, Zhao Q, Underhill C, Tini M, Bedford M, et al. The activity and stability of the transcriptional coactivator p/CIP/SRC-3 are regulated by CARM1-dependent methylation. Mol Cell Biol. 2007;27:120-34 pubmed
    ..p/CIP (p300/CBP interacting protein) is robustly methylated by CARM1 in vitro but not by other protein arginine methyltransferase family members...
  33. Cuthbert G, Daujat S, Snowden A, Erdjument Bromage H, Hagiwara T, Yamada M, et al. Histone deimination antagonizes arginine methylation. Cell. 2004;118:545-53 pubmed
    ..This modification appears on the estrogen-regulated pS2 promoter when the CARM1 methyltransferase is recruited during transcriptional activation...
  34. Wang Y, Li C. Evolutionarily conserved protein arginine methyltransferases in non-mammalian animal systems. FEBS J. 2012;279:932-45 pubmed publisher
    Protein arginine methylation is catalyzed by members of the protein arginine methyltransferase (PRMT) family...
  35. Zhao H, Zhang Y, Dai H, Zhang Y, Shen Y. CARM1 mediates modulation of Sox2. PLoS ONE. 2011;6:e27026 pubmed publisher
    ..in association with and methylated by coactivator-associated arginine methyltransferase 1 (CARM1), a protein arginine methyltransferase that plays a pivotal role in ESCs...
  36. Kim J, Lim Y, Lee J, Lee Y, Won N, Kim H, et al. PRMT4 is involved in insulin secretion via the methylation of histone H3 in pancreatic β cells. J Mol Endocrinol. 2015;54:315-24 pubmed publisher
    ..In the present study, we showed that PRMT4 expression was increased in INS-1 and HIT-T15 pancreatic β cells under high-glucose conditions...
  37. Bhattacherjee V, Horn K, Singh S, Webb C, Pisano M, Greene R. CBP/p300 and associated transcriptional co-activators exhibit distinct expression patterns during murine craniofacial and neural tube development. Int J Dev Biol. 2009;53:1097-104 pubmed publisher
    Mutations in each of the transcriptional co-activator genes - CBP, p300, Cited2, Cart1 and Carm1 - result in neural tube defects in mice...
  38. Chen S, Loffler K, Chen D, Stallcup M, Muscat G. The coactivator-associated arginine methyltransferase is necessary for muscle differentiation: CARM1 coactivates myocyte enhancer factor-2. J Biol Chem. 2002;277:4324-33 pubmed
    ..This prompted us to investigate the functional role of CARM1/PRMT4 during skeletal myogenesis...
  39. Lee Y, Bedford M, Stallcup M. Regulated recruitment of tumor suppressor BRCA1 to the p21 gene by coactivator methylation. Genes Dev. 2011;25:176-88 pubmed publisher
    ..Here we show that coactivator-associated arginine methyltransferase 1 (CARM1) methylates Arg 754 in the KIX region of coactivator p300...
  40. Karakashev S, Zhu H, Wu S, Yokoyama Y, Bitler B, Park P, et al. CARM1-expressing ovarian cancer depends on the histone methyltransferase EZH2 activity. Nat Commun. 2018;9:631 pubmed publisher
    b>CARM1 is an arginine methyltransferase that asymmetrically dimethylates protein substrates on arginine residues. CARM1 is often overexpressed in human cancers...
  41. Kawabe Y, Wang Y, McKinnell I, Bedford M, Rudnicki M. Carm1 regulates Pax7 transcriptional activity through MLL1/2 recruitment during asymmetric satellite stem cell divisions. Cell Stem Cell. 2012;11:333-45 pubmed publisher
    ..We identified the arginine methyltransferase Carm1 as a Pax7 interacting protein and found that Carm1 specifically methylates multiple arginines in the N terminus of ..
  42. Hatanaka Y, Tsusaka T, Shimizu N, Morita K, Suzuki T, Machida S, et al. Histone H3 Methylated at Arginine 17 Is Essential for Reprogramming the Paternal Genome in Zygotes. Cell Rep. 2017;20:2756-2765 pubmed publisher
    ..We identified maternal Mettl23 as a protein arginine methyltransferase (PRMT), which most likely catalyzes the asymmetric dimethylation of histone H3R17 (H3R17me2a), as ..
  43. Mulligan M, Ponomarev I, Hitzemann R, Belknap J, Tabakoff B, Harris R, et al. Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis. Proc Natl Acad Sci U S A. 2006;103:6368-73 pubmed
    ..candidate genes for an alcohol preference quantitative trait locus on chromosome 9 were identified: Arhgef12, Carm1, Cryab, Cox5a, Dlat, Fxyd6, Limd1, Nicn1, Nmnat3, Pknox2, Rbp1, Sc5d, Scn4b, Tcf12, Vps11, and Zfp291 and four ..
  44. Shin H, Kim H, Oh S, Lee J, Kee M, Ko H, et al. AMPK-SKP2-CARM1 signalling cascade in transcriptional regulation of autophagy. Nature. 2016;534:553-7 pubmed publisher
    ..Here we identify co-activator-associated arginine methyltransferase 1 (CARM1) as a crucial component of autophagy in mammals...
  45. Koh S, Li H, Lee Y, Widelitz R, Chuong C, Stallcup M. Synergistic coactivator function by coactivator-associated arginine methyltransferase (CARM) 1 and beta-catenin with two different classes of DNA-binding transcriptional activators. J Biol Chem. 2002;277:26031-5 pubmed
    ..and recruit additional coactivators such as the histone acetyltransferase p300 and the histone methyltransferase CARM1. The current study tested whether CARM1 can cooperate with other types of coactivator proteins...
  46. Li C, Yu L, Xue H, Yang Z, Yin Y, Zhang B, et al. Nuclear AMPK regulated CARM1 stabilization impacts autophagy in aged heart. Biochem Biophys Res Commun. 2017;486:398-405 pubmed publisher
    ..Coactivator-associated arginine methyltransferase 1 (CARM1) participates in many cellular processes, including autophagy in mammals...
  47. Caratù G, Allegra D, Bimonte M, Schiattarella G, D Ambrosio C, Scaloni A, et al. Identification of the ligands of protein interaction domains through a functional approach. Mol Cell Proteomics. 2007;6:333-45 pubmed
    ..Four of them were used as baits to identify the cognate interactors. Among these proteins, CARM1, interacting with the PTB domain of RabGAP1, and EF1alpha, interacting with RGS12, were able to rescue the block ..
  48. Wang S, Dowhan D, Eriksson N, Muscat G. CARM1/PRMT4 is necessary for the glycogen gene expression programme in skeletal muscle cells. Biochem J. 2012;444:323-31 pubmed publisher
    CARM1 (co-activator-associated arginine methyltransferase 1)/PRMT4 (protein arginine methyltransferase 4), functions as a co-activator for transcription factors that are regulators of muscle fibre type and oxidative metabolism, including ..
  49. Fessing M, Mardaryev A, Gdula M, Sharov A, Sharova T, Rapisarda V, et al. p63 regulates Satb1 to control tissue-specific chromatin remodeling during development of the epidermis. J Cell Biol. 2011;194:825-39 pubmed publisher
    ..These data provide a novel mechanism by which Satb1, a direct downstream target of p63, contributes in epidermal morphogenesis via establishing tissue-specific chromatin organization and gene expression in epidermal progenitor cells. ..
  50. Fauquier L, Duboé C, Joré C, Trouche D, Vandel L. Dual role of the arginine methyltransferase CARM1 in the regulation of c-Fos target genes. FASEB J. 2008;22:3337-47 pubmed publisher
    ..Here, we reveal that c-Fos-mediated transcriptional activation is regulated by the protein arginine methyltransferase CARM1 and by all three members of the p160 protein family of coactivators...
  51. Goolam M, Scialdone A, Graham S, Macaulay I, Jedrusik A, Hupalowska A, et al. Heterogeneity in Oct4 and Sox2 Targets Biases Cell Fate in 4-Cell Mouse Embryos. Cell. 2016;165:61-74 pubmed publisher
    ..Furthermore, Sox21 is elevated following increased expression of the histone H3R26-methylase CARM1 and is lowered following CARM1 inhibition, indicating the importance of epigenetic regulation...
  52. Yildirim A, Bulau P, Zakrzewicz D, Kitowska K, Weissmann N, Grimminger F, et al. Increased protein arginine methylation in chronic hypoxia: role of protein arginine methyltransferases. Am J Respir Cell Mol Biol. 2006;35:436-43 pubmed
    ..These data suggest that structural and functional changes caused by hypoxia may be linked to ADMA metabolism. ..
  53. Li J, Zhao Z, Carter C, Ehrlich L, Bedford M, Richie E. Coactivator-associated arginine methyltransferase 1 regulates fetal hematopoiesis and thymocyte development. J Immunol. 2013;190:597-604 pubmed publisher
    Coactivator-associated arginine methyltransferase 1 (CARM1) is a protein arginine methyltransferase that methylates histones and transcriptional regulators...
  54. Hein K, Mittler G, Cizelsky W, Kühl M, Ferrante F, Liefke R, et al. Site-specific methylation of Notch1 controls the amplitude and duration of the Notch1 response. Sci Signal. 2015;8:ra30 pubmed publisher
    ..We found that the methyltransferase CARM1 (coactivator-associated arginine methyltransferase 1; also known as PRMT4) methylated NICD at five conserved arginine residues within the C-terminal transactivation domain...
  55. Kuhn P, Chumanov R, Wang Y, Ge Y, Burgess R, Xu W. Automethylation of CARM1 allows coupling of transcription and mRNA splicing. Nucleic Acids Res. 2011;39:2717-26 pubmed publisher
    Coactivator-associated arginine methyltransferase 1 (CARM1), the histone arginine methyltransferase and coactivator for many transcription factors, is subject to multiple post-translational modifications (PTMs)...
  56. O Brien K, Alberich Jorda M, Yadav N, Kocher O, Diruscio A, Ebralidze A, et al. CARM1 is required for proper control of proliferation and differentiation of pulmonary epithelial cells. Development. 2010;137:2147-56 pubmed publisher
    Coactivator-associated arginine methyltransferase I (CARM1; PRMT4) regulates gene expression by multiple mechanisms including methylation of histones and coactivation of steroid receptor transcription...
  57. Sarker R, John Schuster G, Bohla A, Mutze K, Burgstaller G, Bedford M, et al. Coactivator-Associated Arginine Methyltransferase-1 Function in Alveolar Epithelial Senescence and Elastase-Induced Emphysema Susceptibility. Am J Respir Cell Mol Biol. 2015;53:769-81 pubmed publisher
    ..Coactivator-associated arginine methyltransferase-1 (CARM1) regulates histone methylation and the transcription of genes involved in senescence, proliferation, and ..