Genomes and Genes
Gene Symbol: Car5a
Description: carbonic anhydrase 5a, mitochondrial
Alias: CAV, Ca5a, Car5, carbonic anhydrase 5A, mitochondrial, CA Y, CA-VA, carbonate dehydratase VA, carbonic anhydrase 5, mitochondrial, carbonic anhydrase 5b, mitochondrial, carbonic anhydrase VA
- Jude K, Wright S, Tu C, Silverman D, Viola R, Christianson D. Crystal structure of F65A/Y131C-methylimidazole carbonic anhydrase V reveals architectural features of an engineered proton shuttle. Biochemistry. 2002;41:2485-91 pubmedThe crystal structure of F65A/Y131C murine alpha-carbonic anhydrase V (CAV), covalently modified at cysteine residues with 4-chloromethylimidazole, is reported at 1.88 A resolution...
- Price T, Eranki V, Banks W, Ercal N, Shah G. Topiramate treatment protects blood-brain barrier pericytes from hyperglycemia-induced oxidative damage in diabetic mice. Endocrinology. 2012;153:362-72 pubmed publisher..Thus, mitochondrial CA may provide a new therapeutic target for oxidative stress related illnesses of the central nervous system. ..
- Wu L, Sagong B, Choi J, Kim U, Bok J. A systematic survey of carbonic anhydrase mRNA expression during mammalian inner ear development. Dev Dyn. 2013;242:269-80 pubmed publisher..The temporal and spatial expression patterns of each CA isozyme suggest unique and differential roles in inner ear development and function. ..
- Shah G, Rubbelke T, Hendin J, Nguyen H, Waheed A, Shoemaker J, et al. Targeted mutagenesis of mitochondrial carbonic anhydrases VA and VB implicates both enzymes in ammonia detoxification and glucose metabolism. Proc Natl Acad Sci U S A. 2013;110:7423-8 pubmed publisher..the contribution of each enzyme, we studied the effects of targeted disruption of the murine CA genes, called Car5A and Car5B. The Car5A mutation had several deleterious consequences...