Car2

Summary

Gene Symbol: Car2
Description: carbonic anhydrase 2
Alias: AI131712, CAII, Ca2, Car-2, Ltw-5, Lvtw-5, carbonic anhydrase 2, carbonate dehydratase II, carbonic anhydrase II
Species: mouse
Products:     Car2

Top Publications

  1. Burmeister M, Novak J, Liang M, Basu S, Ploder L, Hawes N, et al. Ocular retardation mouse caused by Chx10 homeobox null allele: impaired retinal progenitor proliferation and bipolar cell differentiation. Nat Genet. 1996;12:376-84 pubmed
    ..off ..
  2. Kernek K, Trofatter J, Mayeda A, Hofstetter J. A locus for circadian period of locomotor activity on mouse proximal chromosome 3. Chronobiol Int. 2004;21:343-52 pubmed
    ..activity is a characteristic of a congenic strain of mice carrying a nonsense mutation in exon 5 of the carbonic anhydrase II gene, car2...
  3. Simpson J, Walker N, Supuran C, Soleimani M, Clarke L. Putative anion transporter-1 (Pat-1, Slc26a6) contributes to intracellular pH regulation during H+-dipeptide transport in duodenal villous epithelium. Am J Physiol Gastrointest Liver Physiol. 2010;298:G683-91 pubmed publisher
    ..Pat-1 interacts with carbonic anhydrase II (CAII), and studies using CAII(-) intestine or the pharmacological inhibitor methazolamide on WT intestine ..
  4. Stridh M, Alt M, Wittmann S, Heidtmann H, Aggarwal M, Riederer B, et al. Lactate flux in astrocytes is enhanced by a non-catalytic action of carbonic anhydrase II. J Physiol. 2012;590:2333-51 pubmed publisher
    ..In the present study, we report that carbonic anhydrase 2 (CAII) enhances both influx and efflux of lactate in mouse cerebellar astrocytes...
  5. Lehtonen J, Shen B, Vihinen M, Casini A, Scozzafava A, Supuran C, et al. Characterization of CA XIII, a novel member of the carbonic anhydrase isozyme family. J Biol Chem. 2004;279:2719-27 pubmed
    ..In conclusion, the predicted amino acid sequence, structural model, distribution, and activity data suggest that CA XIII represents a novel enzyme, which may play important physiological roles in several organs. ..
  6. Pan P, Leppilampi M, Pastorekova S, Pastorek J, Waheed A, Sly W, et al. Carbonic anhydrase gene expression in CA II-deficient (Car2-/-) and CA IX-deficient (Car9-/-) mice. J Physiol. 2006;571:319-27 pubmed
    ..I, II, III, IV, IX, XII, XIII and XIV in the brain, kidney, stomach and colon of the wild-type, CA II-deficient (Car2-/-), and CA IX deficient (Car9-/-) mice...
  7. Leppilampi M, Parkkila S, Karttunen T, Gut M, Gros G, Sjöblom M. Carbonic anhydrase isozyme-II-deficient mice lack the duodenal bicarbonate secretory response to prostaglandin E2. Proc Natl Acad Sci U S A. 2005;102:15247-52 pubmed
    ..0 +/- 2.9 micromol x cm(-1) x h(-1), P < 0.0001. The DBS response to PGE2 was completely absent in Car2-/- mice, whereas basal DBS was normal...
  8. Dou H, Xu J, Wang Z, Smith A, Soleimani M, Karet F, et al. Co-expression of pendrin, vacuolar H+-ATPase alpha4-subunit and carbonic anhydrase II in epithelial cells of the murine endolymphatic sac. J Histochem Cytochem. 2004;52:1377-84 pubmed
  9. Margolis D, Szivek J, Lai L, Lien Y. Phenotypic characteristics of bone in carbonic anhydrase II-deficient mice. Calcif Tissue Int. 2008;82:66-76 pubmed publisher
    b>Carbonic anhydrase II (CAII)-deficient mice were created to study the syndrome of CAII deficiency in humans including osteopetrosis, renal tubular acidosis, and cerebral calcification...
  10. Lewis S, Erickson R, Barnett L, Venta P, Tashian R. N-ethyl-N-nitrosourea-induced null mutation at the mouse Car-2 locus: an animal model for human carbonic anhydrase II deficiency syndrome. Proc Natl Acad Sci U S A. 1988;85:1962-6 pubmed
    ..progeny of male mice treated with N-ethyl-N-nitrosourea revealed a mouse that lacked the paternal carbonic anhydrase II (CA II)...

Detail Information

Publications86

  1. Burmeister M, Novak J, Liang M, Basu S, Ploder L, Hawes N, et al. Ocular retardation mouse caused by Chx10 homeobox null allele: impaired retinal progenitor proliferation and bipolar cell differentiation. Nat Genet. 1996;12:376-84 pubmed
    ..off ..
  2. Kernek K, Trofatter J, Mayeda A, Hofstetter J. A locus for circadian period of locomotor activity on mouse proximal chromosome 3. Chronobiol Int. 2004;21:343-52 pubmed
    ..activity is a characteristic of a congenic strain of mice carrying a nonsense mutation in exon 5 of the carbonic anhydrase II gene, car2...
  3. Simpson J, Walker N, Supuran C, Soleimani M, Clarke L. Putative anion transporter-1 (Pat-1, Slc26a6) contributes to intracellular pH regulation during H+-dipeptide transport in duodenal villous epithelium. Am J Physiol Gastrointest Liver Physiol. 2010;298:G683-91 pubmed publisher
    ..Pat-1 interacts with carbonic anhydrase II (CAII), and studies using CAII(-) intestine or the pharmacological inhibitor methazolamide on WT intestine ..
  4. Stridh M, Alt M, Wittmann S, Heidtmann H, Aggarwal M, Riederer B, et al. Lactate flux in astrocytes is enhanced by a non-catalytic action of carbonic anhydrase II. J Physiol. 2012;590:2333-51 pubmed publisher
    ..In the present study, we report that carbonic anhydrase 2 (CAII) enhances both influx and efflux of lactate in mouse cerebellar astrocytes...
  5. Lehtonen J, Shen B, Vihinen M, Casini A, Scozzafava A, Supuran C, et al. Characterization of CA XIII, a novel member of the carbonic anhydrase isozyme family. J Biol Chem. 2004;279:2719-27 pubmed
    ..In conclusion, the predicted amino acid sequence, structural model, distribution, and activity data suggest that CA XIII represents a novel enzyme, which may play important physiological roles in several organs. ..
  6. Pan P, Leppilampi M, Pastorekova S, Pastorek J, Waheed A, Sly W, et al. Carbonic anhydrase gene expression in CA II-deficient (Car2-/-) and CA IX-deficient (Car9-/-) mice. J Physiol. 2006;571:319-27 pubmed
    ..I, II, III, IV, IX, XII, XIII and XIV in the brain, kidney, stomach and colon of the wild-type, CA II-deficient (Car2-/-), and CA IX deficient (Car9-/-) mice...
  7. Leppilampi M, Parkkila S, Karttunen T, Gut M, Gros G, Sjöblom M. Carbonic anhydrase isozyme-II-deficient mice lack the duodenal bicarbonate secretory response to prostaglandin E2. Proc Natl Acad Sci U S A. 2005;102:15247-52 pubmed
    ..0 +/- 2.9 micromol x cm(-1) x h(-1), P < 0.0001. The DBS response to PGE2 was completely absent in Car2-/- mice, whereas basal DBS was normal...
  8. Dou H, Xu J, Wang Z, Smith A, Soleimani M, Karet F, et al. Co-expression of pendrin, vacuolar H+-ATPase alpha4-subunit and carbonic anhydrase II in epithelial cells of the murine endolymphatic sac. J Histochem Cytochem. 2004;52:1377-84 pubmed
  9. Margolis D, Szivek J, Lai L, Lien Y. Phenotypic characteristics of bone in carbonic anhydrase II-deficient mice. Calcif Tissue Int. 2008;82:66-76 pubmed publisher
    b>Carbonic anhydrase II (CAII)-deficient mice were created to study the syndrome of CAII deficiency in humans including osteopetrosis, renal tubular acidosis, and cerebral calcification...
  10. Lewis S, Erickson R, Barnett L, Venta P, Tashian R. N-ethyl-N-nitrosourea-induced null mutation at the mouse Car-2 locus: an animal model for human carbonic anhydrase II deficiency syndrome. Proc Natl Acad Sci U S A. 1988;85:1962-6 pubmed
    ..progeny of male mice treated with N-ethyl-N-nitrosourea revealed a mouse that lacked the paternal carbonic anhydrase II (CA II)...
  11. Velisek L, Moshe S, Xu S, Cammer W. Reduced susceptibility to seizures in carbonic anhydrase II deficient mutant mice. Epilepsy Res. 1993;14:115-21 pubmed
    The seizure susceptibility of carbonic anhydrase II (CA) deficient mice and their normal littermates was determined and compared...
  12. Jacob C, Mykytyn K, Tashman N. DNA polymorphism in cytokine genes based on length variation in simple-sequence tandem repeats. Immunogenetics. 1993;38:251-7 pubmed
    ..Advantages of short tandemly repeated sequences as genetic markers are discussed in comparison with RFLPs. ..
  13. Nagata M, Ito T, Arimitsu N, Koyama H, Sekimizu K. Transcription arrest relief by S-II/TFIIS during gene expression in erythroblast differentiation. Genes Cells. 2009;14:371-80 pubmed publisher
    ..These results suggest that S-II is involved in transcription of the Bcl-x and beta(major)-globin gene during erythroblast differentiation, by relieving transcription arrest or affecting histone modification on chromatin template. ..
  14. Gonzalez Begne M, Nakamoto T, Nguyen H, Stewart A, Alper S, Melvin J. Enhanced formation of a HCO3- transport metabolon in exocrine cells of Nhe1-/- mice. J Biol Chem. 2007;282:35125-32 pubmed
    ..Indeed, the parotid glands of Nhe1(-/-) mice expressed higher levels of carbonic anhydrase 2 (Car2) polypeptide...
  15. Ruusuvuori E, Huebner A, Kirilkin I, Yukin A, Blaesse P, Helmy M, et al. Neuronal carbonic anhydrase VII provides GABAergic excitatory drive to exacerbate febrile seizures. EMBO J. 2013;32:2275-86 pubmed publisher
    ..Using a novel CA VII (Car7) knockout (KO) mouse as well as a CA II (Car2) KO and a CA II/VII double KO, we show that mature hippocampal pyramidal neurons are endowed with two cytosolic ..
  16. Whyte M. Carbonic anhydrase II deficiency. Clin Orthop Relat Res. 1993;:52-63 pubmed
  17. Whittington D, Grubb J, Waheed A, Shah G, Sly W, Christianson D. Expression, assay, and structure of the extracellular domain of murine carbonic anhydrase XIV: implications for selective inhibition of membrane-associated isozymes. J Biol Chem. 2004;279:7223-8 pubmed
  18. Breton S, Alper S, Gluck S, Sly W, Barker J, Brown D. Depletion of intercalated cells from collecting ducts of carbonic anhydrase II-deficient (CAR2 null) mice. Am J Physiol. 1995;269:F761-74 pubmed
    The kidneys of mice (CAR2-null mice) that are genetically devoid of carbonic anhydrase type II (CAII) were screened by immunocytochemistry with antibodies that distinguish intercalated and principal cells...
  19. Venta P, Montgomery J, Hewett Emmett D, Wiebauer K, Tashian R. Structure and exon to protein domain relationships of the mouse carbonic anhydrase II gene. J Biol Chem. 1985;260:12130-5 pubmed
    ..During this study, the possible basis for the two electrophoretic types, CA IIa and CA IIb, of inbred mouse strains was detected as a Gln/His interchange at position 38. ..
  20. Wang X, Suzawa T, Ohtsuka H, Zhao B, Miyamoto Y, Miyauchi T, et al. Carbonic anhydrase II regulates differentiation of ameloblasts via intracellular pH-dependent JNK signaling pathway. J Cell Physiol. 2010;225:709-19 pubmed publisher
    ..We found that the expression level of carbonic anhydrase II (CAII) is strongly up-regulated in parallel with differentiation of enamel epithelium tissues, while the ..
  21. Munger S, Leinders Zufall T, McDougall L, Cockerham R, Schmid A, Wandernoth P, et al. An olfactory subsystem that detects carbon disulfide and mediates food-related social learning. Curr Biol. 2010;20:1438-44 pubmed publisher
    ..guanylyl cyclase GC-D, the cyclic nucleotide-gated channel subunit CNGA3, and the carbonic anhydrase isoform CAII (GC-D(+) OSNs) is required for the acquisition of socially transmitted food preferences (STFPs) in mice...
  22. Yasukawa Z, Sato C, Kitajima K. Identification of an inflammation-inducible serum protein recognized by anti-disialic acid antibodies as carbonic anhydrase II. J Biochem. 2007;141:429-41 pubmed
    ..The 32-kDa protein was identified as carbonic anhydrase II (CA-II), based on matrix-assisted laser desorption/ionization time-of-flight mass spectrometry analyses of ..
  23. Pan Z, Sikandar S, Witherspoon M, Dizon D, Nguyen T, Benirschke K, et al. Impaired placental trophoblast lineage differentiation in Alkbh1(-/-) mice. Dev Dyn. 2008;237:316-27 pubmed publisher
    ..Our study demonstrates Alkbh1 performs important functions in placental trophoblast lineage differentiation and participates in mechanisms of transcriptional regulation. ..
  24. Sjöblom M, Singh A, Zheng W, Wang J, Tuo B, Krabbenhöft A, et al. Duodenal acidity "sensing" but not epithelial HCO3- supply is critically dependent on carbonic anhydrase II expression. Proc Natl Acad Sci U S A. 2009;106:13094-9 pubmed publisher
    ..Here, we report the physiological role of the intracellular CAII isoform involvement in acid-, PGE(2,) and forskolin-induced murine duodenal bicarbonate secretion (DBS) in vivo...
  25. Jeong H, Jeon U, Koo B, Kim W, Im S, Shin J, et al. Inactivation of Notch signaling in the renal collecting duct causes nephrogenic diabetes insipidus in mice. J Clin Invest. 2009;119:3290-300 pubmed publisher
  26. Savinova O, Sugiyama F, Martin J, Tomarev S, Paigen B, Smith R, et al. Intraocular pressure in genetically distinct mice: an update and strain survey. BMC Genet. 2001;2:12 pubmed
    ..Homozygosity for a null allele of the carbonic anhydrase II gene (Car2n) does not alter IOP while homozygosity for a mutation in the leptin receptor gene (Leprdb) ..
  27. Broad T, Burkin D, Cambridge L, Maher D, Lewis P, Ansari H, et al. Assignment of five loci from human chromosome 8q onto sheep chromosome 9. Cytogenet Cell Genet. 1995;68:102-6 pubmed
    Using a chromosomally characterized minipanel of sheep x hamster cell hybrids, five new loci, including carbonic anhydrase II (CA2), calbindin 1 (28 kDa) (CALB1), corticotropin releasing hormone (CRH), cytochrome P450 11B subfamily XIB (..
  28. Davisson M, Eicher E, Green M. Genes on chromosome 3 of the mouse. J Hered. 1976;67:155-6 pubmed
    ..The Robertsonian translocation Rb(1.3) 1Bnr was used as a marker for the centromere of Chromosome 3. The loci map is as follows: centromere-2.5cM-(Car-1, Car-2)-26cM-my. ..
  29. Serikawa T, Montagutelli X, Simon Chazottes D, Guenet J. Polymorphisms revealed by PCR with single, short-sized, arbitrary primers are reliable markers for mouse and rat gene mapping. Mamm Genome. 1992;3:65-72 pubmed
    ..From these experiments we conclude that, under precisely standardized PCR conditions, the DNA molecules amplified with these arbitrarily designed primers are useful and reliable markers for genetic mapping in both mouse and rat. ..
  30. Curtis P. Cloning of mouse carbonic anhydrase mRNA and its induction in mouse erythroleukemic cells. J Biol Chem. 1983;258:4459-63 pubmed
    ..Hybridization analysis of poly(A+) RNA from uninduced and induced mouse erythroleukemic cells labeled for short and long time periods indicated that induction results in an increase of carbonic anhydrase mRNA in newly synthesized RNA. ..
  31. Kadison A, Maldonado T, Crisera C, Longaker M, Gittes G. In vitro validation of duct differentiation in developing embryonic mouse pancreas. J Surg Res. 2000;90:126-30 pubmed
    ..purpose of this study was to provide such a model by characterizing the expression of two duct markers, carbonic anhydrase II (CAII) and the cystic fibrosis transmembrane conductance regulator (CFTR), in isolated undifferentiated ..
  32. Beechey C, Tweedie S, Spurr N, Ball S, Peters J, Edwards Y. Mapping of mouse carbonic anhydrase-3, Car-3: another locus in the homologous region of mouse chromosome 3 and human chromosome 8. Genomics. 1990;6:692-6 pubmed
  33. Wu L, Sagong B, Choi J, Kim U, Bok J. A systematic survey of carbonic anhydrase mRNA expression during mammalian inner ear development. Dev Dyn. 2013;242:269-80 pubmed publisher
    ..During inner ear development, transcripts of four cytosolic isozymes (Car1, Car2, Car3, and Car13), two membrane-bound isozymes (Car12 and Car14), and two CA-related proteins (Car8 and Car11) were ..
  34. Raft S, Andrade L, Shao D, Akiyama H, Henkemeyer M, Wu D. Ephrin-B2 governs morphogenesis of endolymphatic sac and duct epithelia in the mouse inner ear. Dev Biol. 2014;390:51-67 pubmed publisher
    ..We propose that developmental dysplasias described here are a gene dose-sensitive cause of the vestibular dysfunction observed in EphB-Efnb2 signaling-deficient mice. ..
  35. Ridderstrale Y, Wistrand P, Brechue W. Membrane-associated CA activity in the eye of the CA II-deficient mouse. Invest Ophthalmol Vis Sci. 1994;35:2577-84 pubmed
    ..Inhibition of the CA activity of the basolateral membranes of the ciliary nonpigmented epithelium probably explains the reduction of aqueous humor flow seen after the administration of CA inhibitors. ..
  36. Kogawa M, Wijenayaka A, Ormsby R, Thomas G, Anderson P, Bonewald L, et al. Sclerostin regulates release of bone mineral by osteocytes by induction of carbonic anhydrase 2. J Bone Miner Res. 2013;28:2436-48 pubmed publisher
    ..We found that sclerostin upregulated osteocyte expression of carbonic anhydrase 2 (CA2/Car2), cathepsin K (CTSK/Ctsk), and tartrate-resistant acid phosphatase (ACP5/Acp5)...
  37. Grassmeyer J, Mukherjee M, deRiso J, Hettinger C, Bailey M, Sinha S, et al. Elf5 is a principal cell lineage specific transcription factor in the kidney that contributes to Aqp2 and Avpr2 gene expression. Dev Biol. 2017;424:77-89 pubmed publisher
    ..We have identified Elf5 as an early maker of the principal cell lineage that contributes to the expression of principal cell specific genes. ..
  38. Inada A, Nienaber C, Fonseca S, Bonner Weir S. Timing and expression pattern of carbonic anhydrase II in pancreas. Dev Dyn. 2006;235:1571-7 pubmed
    ..search for genetic markers for assessing the role of duct cells in pancreas growth, we examined whether carbonic anhydrase II (CAII) has ductal cell specificity...
  39. Ramagli L, Womack J, Rodriguez L. Genetic analysis of nonhistone chromosomal protein inheritance in recombinant inbred mouse strains using two-dimensional electrophoresis. Biochem Genet. 1990;28:123-36 pubmed
    ..These 16 NHCP genetic marker inheritance differences detected in RIs add to the 23 previously established genetic marker differences between the progenitors. ..
  40. Paul P, Elliott R. Analysis of the mouse Amy locus in recombinant inbred mouse strains. Biochem Genet. 1987;25:569-79 pubmed
    ..Previously reported differences for strains YBR and CE have been confirmed. New segregation data for carbonic anhydrase, a locus near the proximal end of mouse chromosome 3, are presented. ..
  41. Singh U, Sun T, Shi W, Schulz R, Nuber U, Varanou A, et al. Expression and functional analysis of genes deregulated in mouse placental overgrowth models: Car2 and Ncam1. Dev Dyn. 2005;234:1034-45 pubmed
    ..In the present study, we focused on two genes, Car2 and Ncam1, which both exhibited increased expression in interspecies and cloned hyperplastic placentas...
  42. Jouret F, Auzanneau C, Debaix H, Wada G, Pretto C, Marbaix E, et al. Ubiquitous and kidney-specific subunits of vacuolar H+-ATPase are differentially expressed during nephrogenesis. J Am Soc Nephrol. 2005;16:3235-46 pubmed
    ..They provide new insights into the complex regulation of V-ATPase subunits, the maturation of IC along the nephron, and the pathophysiology of hereditary dRTA. ..
  43. Novak E, Sweet H, Prochazka M, Parentis M, Soble R, Reddington M, et al. Cocoa: a new mouse model for platelet storage pool deficiency. Br J Haematol. 1988;69:371-8 pubmed
    ..Cocoa may be a model for cases of human Hermansky-Pudlak syndrome in which functions of melanosomes and platelet dense granules, but not lysosomes, are involved. ..
  44. Werth M, Schmidt Ott K, Leete T, Qiu A, Hinze C, Viltard M, et al. Transcription factor TFCP2L1 patterns cells in the mouse kidney collecting ducts. elife. 2017;6: pubmed publisher
    ..As a result, Tfcp2l1 regulates the diversification of cell types which is the central characteristic of 'salt and pepper' epithelia and distinguishes the collecting duct from all other nephron segments. ..
  45. Marino L. Characterization of the mouse carbonic anhydrase II gene promoter. J Biol Chem. 1993;268:7081-9 pubmed
    This work characterizes a 250-base pair (bp) fragment of the mouse carbonic anhydrase II (CAII) gene as an efficient but not cell-specific promoter...
  46. José O, Torres Rodríguez P, Forero Quintero L, Chávez J, De la Vega Beltrán J, Carta F, et al. Carbonic anhydrases and their functional differences in human and mouse sperm physiology. Biochem Biophys Res Commun. 2015;468:713-8 pubmed publisher
    ..Importantly, we found that CAII activity accounts for half of the total CA activity in capacitated mouse sperm...
  47. Cerqueira D, Tran U, Romaker D, Abreu J, Wessely O. Sterol carrier protein 2 regulates proximal tubule size in the Xenopus pronephric kidney by modulating lipid rafts. Dev Biol. 2014;394:54-64 pubmed publisher
    ..Together these data underscore the importance for localized signaling platforms in the proper formation of the Xenopus kidney. ..
  48. Mucenski M, Taylor B, Copeland N, Jenkins N. Chromosomal location of Evi-1, a common site of ecotropic viral integration in AKXD murine myeloid tumors. Oncogene Res. 1988;2:219-33 pubmed
    ..These results suggest that Evi-1 represents a new locus involved in myeloid disease. ..
  49. Ueno Y, Ishii M, Takahashi S, Igarashi T, Toyota T, LaRusso N. Different susceptibility of mice to immune-mediated cholangitis induced by immunization with carbonic anhydrase II. Lab Invest. 1998;78:629-37 pubmed
    b>Carbonic anhydrase II (CA-II), an enzyme that catalyzes hydration of carbon dioxide to bicarbonate and hydrogen ions, is located exclusively in cholangiocytes in the liver...
  50. Cornwell M. Molecular biology of P-glycoprotein. Cancer Treat Res. 1991;57:37-56 pubmed
    ..Finally, differential expression of mdr genes encoding P-glycoprotein isoforms with distinct properties appears to be a possible mechanism for generating diversity in MDR rodent cells. ..
  51. LU J, Qian J, Izvolsky K, Cardoso W. Global analysis of genes differentially expressed in branching and non-branching regions of the mouse embryonic lung. Dev Biol. 2004;273:418-35 pubmed
    ..Our data suggest that these genes may regulate focal developmental events specific of each of these regions during respiratory tract formation. ..
  52. Cammer W. Glial-cell cultures from brains of carbonic anhydrase II-deficient mutant mice: delay in oligodendrocyte maturation. Neurochem Res. 1998;23:407-12 pubmed
    b>Carbonic anhydrase II (CAII) is a multifunctional enzyme found in oligodendrocytes and astrocytes in normal mouse brains...
  53. Elliott R. Use of two-dimensional electrophoresis to identify and map new mouse genes. Genetics. 1979;91:295-308 pubmed
    ..These eight genes will be useful reference markers in future crosses designed to map new genes. ..
  54. Eicher E, Stern R, Womack J, Davisson M, Roderick T, Reynolds S. Evolution of mammalian carbonic anhydrase loci by tanden duplication: close linkage of Car-1 and Car-2 to the centromere region of chromosome 3 of the mouse. Biochem Genet. 1976;14:651-60 pubmed
    ..The red blood cells of mice of the subspecies M.m. casteneus have significantly reduced levels of CAR-1 and CAR-2. ..
  55. Lowe N, Edwards Y, Edwards M, Butterworth P. Physical mapping of the human carbonic anhydrase gene cluster on chromosome 8. Genomics. 1991;10:882-8 pubmed
    A cluster of genes encoding the three cytoplasmic carbonic anhydrase isozymes CAI, CAII, and CAIII lie on the long arm of chromosome 8 (8q22) in humans. These genes have been mapped using pulsed-field gel electrophoresis...
  56. Knapp L, Keegan C, Seasholtz A, Camper S. Corticotropin-releasing hormone (Crh) maps to mouse chromosome 3. Mamm Genome. 1993;4:615-7 pubmed
  57. Nguyen C, Singson E, Kim J, Cornelius J, Attia R, Doyle M, et al. Sjögren's syndrome-like disease of C57BL/6.NOD-Aec1 Aec2 mice: gender differences in keratoconjunctivitis sicca defined by a cross-over in the chromosome 3 Aec1 locus. Scand J Immunol. 2006;64:295-307 pubmed
    ..These data suggest SjS-like disease in the NOD mouse shows gender-specific regulation determined by autosomal genes...
  58. Ridderstrale Y, Wistrand P. Membrane-associated carbonic anhydrase activity in the brain of CA II-deficient mice. J Neurocytol. 2000;29:263-9 pubmed
    ..CA II and the membrane-associated CA of choroidal epithelium are probably involved in the secretion of cerebrospinal fluid. ..
  59. Jouret F, Igarashi T, Gofflot F, Wilson P, Karet F, Thakker R, et al. Comparative ontogeny, processing, and segmental distribution of the renal chloride channel, ClC-5. Kidney Int. 2004;65:198-208 pubmed
    ..maturation of ClC-5 during mouse and human nephrogenesis, in comparison with H+-ATPase, type II carbonic anhydrase (CAII), and aquaporin-1 (AQP1). An early induction (E13.5-E14...
  60. Chatel B, Bendahan D, Hourde C, Pellerin L, Lengacher S, Magistretti P, et al. Role of MCT1 and CAII in skeletal muscle pH homeostasis, energetics, and function: in vivo insights from MCT1 haploinsufficient mice. FASEB J. 2017;31:2562-2575 pubmed publisher
    ..01) forces and lower fatigability (P < 0.001) when compared to WT mice. We conclude that both MCT1 and CAII are involved in the homeostatic control of pH in skeletal muscle, both at rest and at the onset of exercise...
  61. Hains D, Chen X, Saxena V, Barr Beare E, Flemming W, Easterling R, et al. Carbonic anhydrase 2 deficiency leads to increased pyelonephritis susceptibility. Am J Physiol Renal Physiol. 2014;307:F869-80 pubmed publisher
    b>Carbonic anhydrase 2 regulates acid-base homeostasis, and recent findings have indicated a correlation between cellular control of acid-base status and the innate defense of the kidney...
  62. Venta P, Montgomery J, Wiebauer K, Hewett Emmett D, Tashian R. Organization of the mouse and human carbonic anhydrase II genes. Ann N Y Acad Sci. 1984;429:309-23 pubmed
  63. Hu J, Spencer T. Carbonic anhydrase regulate endometrial gland development in the neonatal uterus. Biol Reprod. 2005;73:131-8 pubmed
    ..Transcriptional profiling of the developing neonatal mouse uterus detected expression of Car1, Car2, Car11, and Car13 between Postnatal Days (PNDs) 3 and 18...
  64. Whitney J. Novel carbonic anhydrase (Car-2) allele in Spanish mice. Biochem Genet. 1984;22:913-22 pubmed
  65. Velisek L, Moshe S, Stanton P. Resistance of hippocampal synaptic transmission to hypoxia in carbonic anhydrase II-deficient mice. Brain Res. 1995;671:245-53 pubmed
    Mutant Car2n/Car2n mice deficient in carbonic anhydrase II (CA II; a major brain CA isozyme) suffer from systemic acidosis and are more resistant to experimental seizures than their normal littermates (+/+ or +/Car2n)...
  66. Lai L, Chan D, Erickson R, Hsu S, Lien Y. Correction of renal tubular acidosis in carbonic anhydrase II-deficient mice with gene therapy. J Clin Invest. 1998;101:1320-5 pubmed
    b>Carbonic anhydrase II (CAII) deficiency in humans is associated with a syndrome of renal tubular acidosis, osteopetrosis, and cerebral calcification...
  67. Pan P, Waheed A, Sly W, Parkkila S. Carbonic anhydrases in the mouse harderian gland. J Mol Histol. 2010;41:411-7 pubmed publisher
    ..Car5b and Car13 showed the highest signals. Car4, Car6, and Car12 showed moderate expression levels, whereas Car2, Car3, Car7, and Car15 mRNAs were barely within the detection limits...
  68. Stolle C, McGowan M, Heim R, Varia M, Neubauer J. Nucleotide sequence of a cDNA encoding rat brain carbonic anhydrase II and its deduced amino acid sequence. Gene. 1991;109:265-7 pubmed
    A carbonic anhydrase II (CAII)-encoding cDNA clone was isolated from a rat brain lambda gt11 library. The 1459-bp cDNA codes for 260 amino acids with sequence similarity to mouse and human CAII and hybridizes to a single 1.7-kb mRNA.
  69. Beekley M, Wetzel P, Kubis H, Gros G. Contractile properties of skeletal muscle fibre bundles from mice deficient in carbonic anhydrase II. Pflugers Arch. 2006;452:453-63 pubmed
    ..In conclusion, skeletal muscle from mice deficient in CA II exhibits altered handling of acid-base challenges and shows normal contractile behavior at normal intracellular pH. ..
  70. Cammer W, Zhang H, Tansey F. Effects of carbonic anhydrase II (CAII) deficiency on CNS structure and function in the myelin-deficient CAII-deficient double mutant mouse. J Neurosci Res. 1995;40:451-7 pubmed
    In the choroid plexus carbonic anhydrase II (CAII) supports the transport of bicarbonate ions, sodium ions, and water from blood to the CSF, and in the myelin sheath CAII supports compaction of myelin by stimulating cotransport of ions ..
  71. Palminiello S, Kida E, Kaur K, Walus M, Wisniewski K, Wierzba Bobrowicz T, et al. Increased levels of carbonic anhydrase II in the developing Down syndrome brain. Brain Res. 2008;1190:193-205 pubmed
    By using a proteomic approach, we found increased levels of carbonic anhydrase II (CA II) in the brain of Ts65Dn mice, a mouse model for Down syndrome (DS)...
  72. Crisera C, Kadison A, Breslow G, Maldonado T, Longaker M, Gittes G. Expression and role of laminin-1 in mouse pancreatic organogenesis. Diabetes. 2000;49:936-44 pubmed
    ..Immunohistochemistry, however, showed that pancreatic duct cell-specific differentiation (carbonic anhydrase II) without ductal morphogenesis was still present, despite the blockage of duct morphogenesis by the anti-..
  73. Racine R, Langley C. Genetic analysis of protein variations in Mus musculus using two-dimensional electrophoresis. Biochem Genet. 1980;18:185-97 pubmed
    ..Out of the 100 loci screened, we have found nine loci showing interstrain differences. We have found also that differences in the protein pattern as seen on two-dimensional gels are small among subspecies of Mus musculus. ..
  74. Githens S, Schexnayder J, Frazier M. Carbonic anhydrase II gene expression in mouse pancreatic duct cells. Pancreas. 1992;7:556-61 pubmed
    ..The concentration of CA II mRNA in the cultured duct cells was substantially greater than in whole pancreas and would appear to account for the majority, if not all, of the CA II in the mouse pancreas. ..
  75. Moseley W, Seldin M. Definition of mouse chromosome 1 and 3 gene linkage groups that are conserved on human chromosome 1: evidence that a conserved linkage group spans the centromere of human chromosome 1. Genomics. 1989;5:899-905 pubmed
    ..These studies provide a model for examination of specific evolutionary events. ..
  76. Kernek K, Trofatter J, Mayeda A, Lahiri D, Hofstetter J. A single copy of carbonic anhydrase 2 restores wild-type circadian period to carbonic anhydrase II-deficient mice. Behav Genet. 2006;36:301-8 pubmed
    b>Carbonic anhydrase II (CA-II)-deficient mice have long circadian periods compared to their siblings with normal CA-II levels...
  77. von Deimling O, Gaa A. Biochemical and genetic characterization of esterase-27 (ES-27), the major plasma cholinesterase of the house mouse (Mus musculus). Genet Res. 1991;57:61-70 pubmed
    ..From a three-point cross (AKR/Han, A/Wy) and a five-point cross (AKR/Han, SEG/1), the gene order on chromosome 3 was concluded to be centromere-Car-2-Es-26-Es-27-Amy-1-Adh-1. ..
  78. Delprato A, Bonheur B, Algéo M, Rosay P, Lu L, Williams R, et al. Systems genetic analysis of hippocampal neuroanatomy and spatial learning in mice. Genes Brain Behav. 2015;14:591-606 pubmed publisher
    ..Gpc4 and Tenm2 are strong candidate genes that may modulate IIPMF areas. Analysis of gene expression networks and trait correlations highlight several processes influencing morphometrical variation and spatial learning. ..
  79. Henry E, Sy C, Inclan Rico J, Espinosa V, Ghanny S, Dwyer D, et al. Carbonic anhydrase enzymes regulate mast cell-mediated inflammation. J Exp Med. 2016;213:1663-73 pubmed publisher
  80. Nogradi A, Jonsson N, Walker R, Caddy K, Carter N, Kelly C. Carbonic anhydrase II and carbonic anhydrase-related protein in the cerebellar cortex of normal and lurcher mice. Brain Res Dev Brain Res. 1997;98:91-101 pubmed
    The developmental profiles of carbonic anhydrase II (CA-II) and a carbonic anhydrase related protein (CARP) were studied in rat and mouse cerebella...