Gene Symbol: Car14
Description: carbonic anhydrase 14
Alias: AW536446, CA-XIV, Ca14, carbonic anhydrase 14, CA XIV, carbonate dehydratase XIV, carbonic anhydrase XIV
Species: mouse
Products:     Car14

Top Publications

  1. Nagelhus E, Mathiisen T, Bateman A, Haug F, Ottersen O, Grubb J, et al. Carbonic anhydrase XIV is enriched in specific membrane domains of retinal pigment epithelium, Muller cells, and astrocytes. Proc Natl Acad Sci U S A. 2005;102:8030-5 pubmed
    ..b>CA XIV, an extracellular membrane-bound CA, was recently shown to be present in brain and retina...
  2. Ogilvie J, Ohlemiller K, Shah G, Ulmasov B, Becker T, Waheed A, et al. Carbonic anhydrase XIV deficiency produces a functional defect in the retinal light response. Proc Natl Acad Sci U S A. 2007;104:8514-9 pubmed
    ..CA IV and CA XIV are membrane-bound isozymes expressed in the eye...
  3. Mori K, Ogawa Y, Ebihara K, Tamura N, Tashiro K, Kuwahara T, et al. Isolation and characterization of CA XIV, a novel membrane-bound carbonic anhydrase from mouse kidney. J Biol Chem. 1999;274:15701-5 pubmed
    ..sequence, a CA domain, a transmembrane domain, and a short hydrophilic carboxyl terminus, which we designated CA XIV. The CA domain of CA XIV is highly homologous with those of known CAs, especially extracellular CAs including CA ..
  4. Scheibe R, Mundhenk K, Becker T, Hallerdei J, Waheed A, Shah G, et al. Carbonic anhydrases IV and IX: subcellular localization and functional role in mouse skeletal muscle. Am J Physiol Cell Physiol. 2008;294:C402-12 pubmed
  5. Shah G, Ulmasov B, Waheed A, Becker T, Makani S, Svichar N, et al. Carbonic anhydrase IV and XIV knockout mice: roles of the respective carbonic anhydrases in buffering the extracellular space in brain. Proc Natl Acad Sci U S A. 2005;102:16771-6 pubmed
    ..two isozymes in this and other physiological functions attributed to extracellular CAs, we produced CA IV and CA XIV knockout (KO) mice by targeted mutagenesis and the doubly deficient CA IV/XIV KO mice by intercrossing the ..
  6. Scheibe R, Gros G, Parkkila S, Waheed A, Grubb J, Shah G, et al. Expression of membrane-bound carbonic anhydrases IV, IX, and XIV in the mouse heart. J Histochem Cytochem. 2006;54:1379-91 pubmed
    Expression of membrane-bound carbonic anhydrases (CAs) of CA IV, CA IX, CA XII, and CA XIV has been investigated in the mouse heart...
  7. Wetzel P, Scheibe R, Hellmann B, Hallerdei J, Shah G, Waheed A, et al. Carbonic anhydrase XIV in skeletal muscle: subcellular localization and function from wild-type and knockout mice. Am J Physiol Cell Physiol. 2007;293:C358-66 pubmed
    ..Sarcoplasmic reticulum (SR) and sarcolemmal (SL) membrane fractions were isolated from wild-type (WT) and CA XIV knockout (KO) mice...
  8. Casey J, Sly W, Shah G, Alvarez B. Bicarbonate homeostasis in excitable tissues: role of AE3 Cl-/HCO3- exchanger and carbonic anhydrase XIV interaction. Am J Physiol Cell Physiol. 2009;297:C1091-102 pubmed publisher
    ..Association of AE3 and CAXIV may represent a mechanism to enhance disposal of waste CO(2) and to balance pH in excitable tissues. ..
  9. Reibring C, El Shahawy M, Hallberg K, Kannius Janson M, Nilsson J, Parkkila S, et al. Expression patterns and subcellular localization of carbonic anhydrases are developmentally regulated during tooth formation. PLoS ONE. 2014;9:e96007 pubmed publisher
    ..Our study provides important information for future single or multiple gene targeting strategies aiming at deciphering the function of CAs during odontogenesis. ..

More Information


  1. Whittington D, Grubb J, Waheed A, Shah G, Sly W, Christianson D. Expression, assay, and structure of the extracellular domain of murine carbonic anhydrase XIV: implications for selective inhibition of membrane-associated isozymes. J Biol Chem. 2004;279:7223-8 pubmed
    ..Full-length CA XIV is a transmembrane protein composed of an extracellular catalytic domain, a single transmembrane helix, and a ..
  2. Pan P, Rodriguez A, Parkkila S. A systematic quantification of carbonic anhydrase transcripts in the mouse digestive system. BMC Mol Biol. 2007;8:22 pubmed
    ..Car3, Car12, Car13, and Car14 were detected in seven out of eight tissues and Car2 and Car4 were expressed in six tissues...
  3. Hallerdei J, Scheibe R, Parkkila S, Waheed A, Sly W, Gros G, et al. T tubules and surface membranes provide equally effective pathways of carbonic anhydrase-facilitated lactic acid transport in skeletal muscle. PLoS ONE. 2010;5:e15137 pubmed publisher
    ..The data suggest that about half the CA-dependent muscular lactate flux occurs across the surface membrane, while the other half occurs across the membranes of the T tubuli. ..
  4. Vargas L, Alvarez B. Carbonic anhydrase XIV in the normal and hypertrophic myocardium. J Mol Cell Cardiol. 2012;52:741-52 pubmed publisher
    ..Increased CAXIV expression and consequent AE3/CAXIV complex formation would render AE3 hyperactive in the SHR heart. ..
  5. Supuran C. Carbonic anhydrases as drug targets--an overview. Curr Top Med Chem. 2007;7:825-33 pubmed
    ..isozymes are cytosolic (CA I, CA II, CA III, CA VII, CA XIII), others are membrane-bound (CA IV, CA IX, CA XII, CA XIV and CA XV), CA VA and CA VB are mitochondrial, and CA VI is secreted in saliva and milk...
  6. Wu L, Sagong B, Choi J, Kim U, Bok J. A systematic survey of carbonic anhydrase mRNA expression during mammalian inner ear development. Dev Dyn. 2013;242:269-80 pubmed publisher
    ..transcripts of four cytosolic isozymes (Car1, Car2, Car3, and Car13), two membrane-bound isozymes (Car12 and Car14), and two CA-related proteins (Car8 and Car11) were expressed at higher levels than other isozymes...
  7. Makani S, Chen H, Esquenazi S, Shah G, Waheed A, Sly W, et al. NMDA receptor-dependent afterdepolarizations are curtailed by carbonic anhydrase 14: regulation of a short-term postsynaptic potentiation. J Neurosci. 2012;32:16754-62 pubmed publisher
    ..We studied the role of Car14 in this brain structure, in which it is expressed solely on neurons...
  8. Svichar N, Waheed A, Sly W, Hennings J, Hübner C, Chesler M. Carbonic anhydrases CA4 and CA14 both enhance AE3-mediated Cl--HCO3- exchange in hippocampal neurons. J Neurosci. 2009;29:3252-8 pubmed publisher
    Carbonic anhydrase (CA) activity in the brain extracellular space is attributable mainly to isoforms CA4 and CA14. In brain, these enzymes have been studied mostly in the context of buffering activity-dependent extracellular pH transients...
  9. Parkkila S, Kivela A, Kaunisto K, Parkkila A, Hakkola J, Rajaniemi H, et al. The plasma membrane carbonic anhydrase in murine hepatocytes identified as isozyme XIV. BMC Gastroenterol. 2002;2:13 pubmed
    ..blotting results indicated the presence of mRNA for the most recently discovered membrane-bound CA isozyme, CA XIV, in the liver...