Gene Symbol: Car12
Description: carbonic anhydrase 12
Alias: 2310047E01Rik, AI314958, CA-XII, Ca12, carbonic anhydrase 12, CA XII, carbonate dehydratase XII, carbonic anhydrase XII
Species: mouse
Products:     Car12

Top Publications

  1. Kyllönen M, Parkkila S, Rajaniemi H, Waheed A, Grubb J, Shah G, et al. Localization of carbonic anhydrase XII to the basolateral membrane of H+-secreting cells of mouse and rat kidney. J Histochem Cytochem. 2003;51:1217-24 pubmed
    ..CA activity has been localized to both luminal and basolateral membranes of the tubule epithelial cells. CA XII is a transmembrane isoenzyme that has been demonstrated in the basolateral plasma membrane of human renal, ..
  2. Clark K, Geurts A, Bell J, Hackett P. Transposon vectors for gene-trap insertional mutagenesis in vertebrates. Genesis. 2004;39:225-33 pubmed
  3. Halmi P, Lehtonen J, Waheed A, Sly W, Parkkila S. Expression of hypoxia-inducible, membrane-bound carbonic anhydrase isozyme XII in mouse tissues. Anat Rec A Discov Mol Cell Evol Biol. 2004;277:171-7 pubmed
    ..In mouse, CA XII has been recently localized in the kidney...
  4. Hynninen P, Hämäläinen J, Pastorekova S, Pastorek J, Waheed A, Sly W, et al. Transmembrane carbonic anhydrase isozymes IX and XII in the female mouse reproductive organs. Reprod Biol Endocrinol. 2004;2:73 pubmed
    ..The data of our study indicated that CA XII is expressed in the mouse endometrium...
  5. Whittington D, Grubb J, Waheed A, Shah G, Sly W, Christianson D. Expression, assay, and structure of the extracellular domain of murine carbonic anhydrase XIV: implications for selective inhibition of membrane-associated isozymes. J Biol Chem. 2004;279:7223-8 pubmed
    ..amino acid sequence identity of human CA XIV relative to the other membrane-associated isozymes (CA IV, CA IX, and CA XII) is 34-46%...
  6. Kallio H, Pastorekova S, Pastorek J, Waheed A, Sly W, Mannisto S, et al. Expression of carbonic anhydrases IX and XII during mouse embryonic development. BMC Dev Biol. 2006;6:22 pubmed
    ..The expression pattern of CA XII in the embryonic tissues was also relatively broad, although the intensity of immunostaining was weak in most ..
  7. Geurts A, Wilber A, Carlson C, Lobitz P, Clark K, Hackett P, et al. Conditional gene expression in the mouse using a Sleeping Beauty gene-trap transposon. BMC Biotechnol. 2006;6:30 pubmed
    ..These mice would be a valuable resource to the mouse genetics community for purpose of dissecting mammalian gene function. ..
  8. Pan P, Rodriguez A, Parkkila S. A systematic quantification of carbonic anhydrase transcripts in the mouse digestive system. BMC Mol Biol. 2007;8:22 pubmed
    ..Car3, Car12, Car13, and Car14 were detected in seven out of eight tissues and Car2 and Car4 were expressed in six tissues...
  9. Pan P, Waheed A, Sly W, Parkkila S. Carbonic anhydrases in the mouse harderian gland. J Mol Histol. 2010;41:411-7 pubmed publisher
    ..Nine CA mRNAs were detectable in the gland. Car5b and Car13 showed the highest signals. Car4, Car6, and Car12 showed moderate expression levels, whereas Car2, Car3, Car7, and Car15 mRNAs were barely within the detection ..

More Information


  1. Wu L, Sagong B, Choi J, Kim U, Bok J. A systematic survey of carbonic anhydrase mRNA expression during mammalian inner ear development. Dev Dyn. 2013;242:269-80 pubmed publisher
    ..development, transcripts of four cytosolic isozymes (Car1, Car2, Car3, and Car13), two membrane-bound isozymes (Car12 and Car14), and two CA-related proteins (Car8 and Car11) were expressed at higher levels than other isozymes...
  2. Bouchareb R, Côté N, Marie Chloé Boulanger -, Le Quang K, El Husseini D, Asselin J, et al. Carbonic anhydrase XII in valve interstitial cells promotes the regression of calcific aortic valve stenosis. J Mol Cell Cardiol. 2015;82:104-15 pubmed publisher
    ..We documented that agonist of P2Y2 receptor (P2Y2R) promoted the expression of carbonic anhydrase XII (CAXII) at the cell membrane of VICs, whereby minerals are resorbed...