CAPS1

Summary

Gene Symbol: CAPS1
Description: Ca2+-dependent secretion activator
Alias: AU067781, CAPS, CAPS1, mKIAA1121, calcium-dependent secretion activator 1, Ca2+-dependent activator protein for secretion, Ca<2+>dependent activator protein for secretion, calcium-dependent activator protein for secretion 1
Species: mouse
Products:     CAPS1

Top Publications

  1. Speidel D, Salehi A, Obermueller S, Lundquist I, Brose N, Renstrom E, et al. CAPS1 and CAPS2 regulate stability and recruitment of insulin granules in mouse pancreatic beta cells. Cell Metab. 2008;7:57-67 pubmed publisher
    b>CAPS1 and CAPS2 regulate dense-core vesicle release of transmitters and hormones in neuroendocrine cells, but their precise roles in the secretory process remain enigmatic...
  2. Speidel D, Varoqueaux F, Enk C, Nojiri M, Grishanin R, Martin T, et al. A family of Ca2+-dependent activator proteins for secretion: comparative analysis of structure, expression, localization, and function. J Biol Chem. 2003;278:52802-9 pubmed
    ..The structure of CAPS2 and its function in LDCV exocytosis from PC12 cells are very similar to those of CAPS1. Both isoforms are strongly expressed in neuroendocrine cells and in the brain...
  3. Speidel D, Bruederle C, Enk C, Voets T, Varoqueaux F, Reim K, et al. CAPS1 regulates catecholamine loading of large dense-core vesicles. Neuron. 2005;46:75-88 pubmed
    b>CAPS1 is thought to play an essential role in mediating exocytosis from large dense-core vesicles (LDCVs)...
  4. Jockusch W, Speidel D, Sigler A, S rensen J, Varoqueaux F, Rhee J, et al. CAPS-1 and CAPS-2 are essential synaptic vesicle priming proteins. Cell. 2007;131:796-808 pubmed publisher
    ..We show that CAPS-1 and CAPS-2 are essential components of the synaptic vesicle priming machinery...
  5. Liu Y, Schirra C, Stevens D, Matti U, Speidel D, Hof D, et al. CAPS facilitates filling of the rapidly releasable pool of large dense-core vesicles. J Neurosci. 2008;28:5594-601 pubmed publisher
    Calcium-activator protein for secretion (CAPS) is a cytosolic protein that associates with large dense-core vesicles and is involved in their secretion...
  6. Walter A, Müller R, Tawfik B, Wierda K, Pinheiro P, Nadler A, et al. Phosphatidylinositol 4,5-bisphosphate optical uncaging potentiates exocytosis. elife. 2017;6: pubmed publisher
    ..PI(4,5)P2 activation of exocytosis did not depend on the PI(4,5)P2-binding CAPS-proteins, suggesting that PI(4,5)P2 uncaging may bypass CAPS-function...
  7. Miyake K, Ohta T, Nakayama H, Doe N, Terao Y, Oiki E, et al. CAPS1 RNA Editing Promotes Dense Core Vesicle Exocytosis. Cell Rep. 2016;17:2004-2014 pubmed publisher
    Calcium-dependent activator protein for secretion 1 (CAPS1) plays a distinct role in the priming step of dense core vesicle (DCV) exocytosis...
  8. Shinoda Y, Ishii C, Fukazawa Y, Sadakata T, Ishii Y, Sano Y, et al. CAPS1 stabilizes the state of readily releasable synaptic vesicles to fusion competence at CA3-CA1 synapses in adult hippocampus. Sci Rep. 2016;6:31540 pubmed publisher
    Calcium-dependent activator protein for secretion 1 (CAPS1) regulates exocytosis of dense-core vesicles in neuroendocrine cells and of synaptic vesicles in neurons...
  9. Hosono M, Shinoda Y, Hirano T, Ishizaki Y, Furuichi T, Sadakata T. Interaction of Ca(2+)-dependent activator protein for secretion 1 (CAPS1) with septin family proteins in mouse brain. Neurosci Lett. 2016;617:232-5 pubmed publisher
    The Ca(2+)-dependent activator protein for secretion 1 (CAPS1) protein plays a regulatory role in the dense-core vesicle exocytosis pathway...

More Information

Publications31

  1. Brunk I, Blex C, Speidel D, Brose N, Ahnert Hilger G. Ca2+-dependent activator proteins of secretion promote vesicular monoamine uptake. J Biol Chem. 2009;284:1050-6 pubmed publisher
    ..b>CAPS1 appears to have an additional and as yet unexplained function in vesicular catecholamine uptake or storage as ..
  2. Parsaud L, Li L, Jung C, Park S, Saw N, Park S, et al. Calcium-dependent activator protein for secretion 1 (CAPS1) binds to syntaxin-1 in a distinct mode from Munc13-1. J Biol Chem. 2013;288:23050-63 pubmed publisher
    Calcium-dependent activator protein for secretion 1 (CAPS1) is a multidomain protein containing a Munc13 homology domain 1 (MHD1)...
  3. Sadakata T, Mizoguchi A, Sato Y, Katoh Semba R, Fukuda M, Mikoshiba K, et al. The secretory granule-associated protein CAPS2 regulates neurotrophin release and cell survival. J Neurosci. 2004;24:43-52 pubmed
    ..expressed in granule cells of postnatally developing mouse cerebellum, which turned out to be a paralog of CAPS (Ca2+-dependent activator protein for secretion), and named CAPS2...
  4. Burgalossi A, Jung S, Meyer G, Jockusch W, Jahn O, Taschenberger H, et al. SNARE protein recycling by ?SNAP and ?SNAP supports synaptic vesicle priming. Neuron. 2010;68:473-87 pubmed publisher
    ..Our analysis of ?- and ?SNAP deletion mutant neurons shows that the two NSF cofactors support synaptic vesicle priming by determining the availability of free SNARE components, particularly during phases of high synaptic activity. ..
  5. Janova H, Arinrad S, Balmuth E, Mitjans M, Hertel J, Habes M, et al. Microglia ablation alleviates myelin-associated catatonic signs in mice. J Clin Invest. 2018;128:734-745 pubmed publisher
    ..Since the catatonic syndrome is likely a surrogate marker for other executive function defects, we suggest that microglia-directed therapies may be considered in psychiatric disorders associated with myelin abnormalities. ..
  6. Daniel J, Dangelmaier C, Mada S, Buitrago L, Jin J, Langdon W, et al. Cbl-b is a novel physiologic regulator of glycoprotein VI-dependent platelet activation. J Biol Chem. 2010;285:17282-91 pubmed publisher
    ..These data indicate that Cbl-b plays a positive modulatory role in GPVI-dependent platelet signaling, which translates to an important regulatory role in hemostasis and thrombosis in vivo. ..
  7. Imig C, Min S, Krinner S, Arancillo M, Rosenmund C, Südhof T, et al. The morphological and molecular nature of synaptic vesicle priming at presynaptic active zones. Neuron. 2014;84:416-31 pubmed publisher
    ..zone recruitment (tethering) and membrane attachment (docking) and found that vesicle docking requires Munc13/CAPS family priming proteins and all three neuronal SNAREs, but not Synaptotagmin-1 or Complexins...
  8. Eckenstaler R, Lessmann V, Brigadski T. CAPS1 effects on intragranular pH and regulation of BDNF release from secretory granules in hippocampal neurons. J Cell Sci. 2016;129:1378-90 pubmed publisher
    ..Here, we demonstrate the relevance of the priming factor CAPS1 (also known as CADPS) for the maturation and exocytosis of BDNF-containing secretory granules, as well as for ..
  9. Sadakata T, Shinoda Y, Sekine Y, Saruta C, Itakura M, Takahashi M, et al. Interaction of calcium-dependent activator protein for secretion 1 (CAPS1) with the class II ADP-ribosylation factor small GTPases is required for dense-core vesicle trafficking in the trans-Golgi network. J Biol Chem. 2010;285:38710-9 pubmed publisher
    ..The present study shows that somal CAPS1 plays an important role in DCV trafficking in the trans-Golgi network...
  10. Sadakata T, Itakura M, Kozaki S, Sekine Y, Takahashi M, Furuichi T. Differential distributions of the Ca2+ -dependent activator protein for secretion family proteins (CAPS2 and CAPS1) in the mouse brain. J Comp Neurol. 2006;495:735-53 pubmed
    The Ca(2+)-dependent activator protein for secretion (CAPS/Cadps) family consists of two members, CAPS1 and CAPS2, and plays an important role in secretory granule exocytosis...
  11. Piccoli G, Condliffe S, Bauer M, Giesert F, Boldt K, De Astis S, et al. LRRK2 controls synaptic vesicle storage and mobilization within the recycling pool. J Neurosci. 2011;31:2225-37 pubmed publisher
    ..Our results suggest that LRRK2 modulates synaptic vesicle trafficking and distribution in neurons and in consequence participates in regulating the dynamics between vesicle pools inside the presynaptic bouton...
  12. Fujita Y, Xu A, Xie L, Arunachalam L, Chou T, Jiang T, et al. Ca2+-dependent activator protein for secretion 1 is critical for constitutive and regulated exocytosis but not for loading of transmitters into dense core vesicles. J Biol Chem. 2007;282:21392-403 pubmed
    Although CAPS1 was originally identified as a soluble factor that reconstitutes Ca(2+)-dependent secretion from permeabilized neuroendocrine cells, its exact function in intact mammalian cells remains controversial...
  13. Sadakata T, Furuichi T. Developmentally regulated Ca2+-dependent activator protein for secretion 2 (CAPS2) is involved in BDNF secretion and is associated with autism susceptibility. Cerebellum. 2009;8:312-22 pubmed publisher
    ..These recent studies implicate CAPS2 in autism susceptibility. Therefore, CAPS2(-/-) mice will be a useful model animal in which to study aspects of the neuropathology and behaviors characteristic of developmental disorders. ..
  14. Nguyen Truong C, Nestvogel D, Ratai O, Schirra C, Stevens D, Brose N, et al. Secretory vesicle priming by CAPS is independent of its SNARE-binding MUN domain. Cell Rep. 2014;9:902-9 pubmed publisher
    ..We studied naturally occurring splice variants of CAPS2 in CAPS1/CAPS2-deficient cells and found that CAPS2 primes vesicles independently of its MUN domain...
  15. Liu Y, Schirra C, Edelmann L, Matti U, Rhee J, Hof D, et al. Two distinct secretory vesicle-priming steps in adrenal chromaffin cells. J Cell Biol. 2010;190:1067-77 pubmed publisher
    ..Either CAPS1 or CAPS2 can rescue secretion in cells lacking both CAPS isoforms...
  16. Rybkin I, Kim M, Bezprozvannaya S, Qi X, Richardson J, Plato C, et al. Regulation of atrial natriuretic peptide secretion by a novel Ras-like protein. J Cell Biol. 2007;179:527-37 pubmed
    ..RRP17 interacts with Ca(2+)-activated protein for secretion-1 (CAPS1), one of only a few proteins known to be associated exclusively with LDCV exocytosis...
  17. Vogl C, Cooper B, Neef J, Wojcik S, Reim K, Reisinger E, et al. Unconventional molecular regulation of synaptic vesicle replenishment in cochlear inner hair cells. J Cell Sci. 2015;128:638-44 pubmed publisher
    ..the mammalian uncoordinated 13 (Munc13, also known as Unc13) and Ca(2+)-dependent activator proteins for secretion (CAPS) families, which prime vesicles for exocytosis...
  18. Farina M, van de Bospoort R, He E, Persoon C, van Weering J, Broeke J, et al. CAPS-1 promotes fusion competence of stationary dense-core vesicles in presynaptic terminals of mammalian neurons. elife. 2015;4: pubmed publisher
    ..We studied the role of calcium-activator protein for secretion (CAPS) proteins in neuronal DCV secretion at single vesicle resolution...
  19. Sadakata T, Kakegawa W, Shinoda Y, Hosono M, Katoh Semba R, Sekine Y, et al. CAPS1 deficiency perturbs dense-core vesicle trafficking and Golgi structure and reduces presynaptic release probability in the mouse brain. J Neurosci. 2013;33:17326-34 pubmed publisher
    Ca(2+)-dependent activator protein for secretion 1 (CAPS1) plays a regulatory role in the dense-core vesicle (DCV) exocytosis pathway, but its functions at the cellular and synaptic levels in the brain are essentially unknown because of ..
  20. Sadakata T, Sekine Y, Oka M, Itakura M, Takahashi M, Furuichi T. Calcium-dependent activator protein for secretion 2 interacts with the class II ARF small GTPases and regulates dense-core vesicle trafficking. FEBS J. 2012;279:384-94 pubmed publisher
    The Ca(2+) -dependent activator protein for secretion (CAPS) family consists of two members (CAPS1 and CAPS2) and regulates the exocytosis of catecholamine-containing or neuropeptide-containing dense-core vesicles (DCVs) at secretion ..
  21. Nojiri M, Loyet K, Klenchin V, Kabachinski G, Martin T. CAPS activity in priming vesicle exocytosis requires CK2 phosphorylation. J Biol Chem. 2009;284:18707-14 pubmed publisher
    b>CAPS (Ca(2+)-dependent activator protein for secretion) functions in priming Ca(2+)-dependent vesicle exocytosis, but the regulation of CAPS activity has not been characterized...
  22. Cisternas F, Vincent J, Scherer S, Ray P. Cloning and characterization of human CADPS and CADPS2, new members of the Ca2+-dependent activator for secretion protein family. Genomics. 2003;81:279-91 pubmed
    ..We identified several nucleotide substitutions, including only one that would affect the amino acid sequence. No disease-specific variants were identified. ..