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Genomes and Genes
| CanxSummaryGene Symbol: Canx Description: calnexin Alias: 1110069N15Rik, AI988026, Cnx, D11Ertd153e Species: mouse Top Publications
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Publications
Calnexin: a membrane-bound chaperone of the endoplasmic reticulumJ J Bergeron
Department of Anatomy and Cell Biology, McGill University, Montreal, Quebec, Canada
Trends Biochem Sci 19:124-8. 1994..One of its demonstrated functions is the retention of incorrectly or incompletely folded proteins, suggesting that calnexin is a component of the quality control system of the endoplasmic reticulum...
Endoplasmic reticulum stress in the absence of calnexinHelen Coe
Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada
Cell Stress Chaperones 13:497-507. 2008..This indicates that cnx (-/-) cells have increased constitutively active UPR...- GRP78/BiP is required for cell proliferation and protecting the inner cell mass from apoptosis during early mouse embryonic developmentShengzhan Luo
Department of Biochemistry and Molecular Biology and the USC Norris Comprehensive Cancer Center, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90089 9176, USA
Mol Cell Biol 26:5688-97. 2006..These findings provide the first evidence that GRP78 is essential for embryonic cell growth and pluripotent cell survival... - Calnexin deficiency leads to dysmyelinationAllison Kraus
Department of Biochemistry, School of Molecular and Systems Medicine, University of Alberta, Edmonton, Alberta T6G 2H7, Canada
J Biol Chem 285:18928-38. 2010..We have generated calnexin gene-deficient mice (cnx(-/-)) and showed that calnexin deficiency leads to myelinopathy... - Human, mouse, and rat calnexin cDNA cloning: identification of potential calcium binding motifs and gene localization to human chromosome 5L W Tjoelker
ICOS Corporation, Bothell, Washington 98021
Biochemistry 33:3229-36. 1994..The gene for human calnexin is located on the distal end of the long arm of human chromosome 5, at 5q35... - Beyond lectins: the calnexin/calreticulin chaperone system of the endoplasmic reticulumDavid B Williams
Department of Biochemistry and Immunology, University of Toronto, Toronto, Ontario, Canada, M5S 1A8
J Cell Sci 119:615-23. 2006..Furthermore, there is clear evidence that ERp57 participates in glycoprotein biogenesis either alone or in tandem with calnexin and calreticulin... - Contrasting functions of calreticulin and calnexin in glycoprotein folding and ER quality controlMaurizio Molinari
Institute for Research in Biomedicine, CH 6500 Bellinzona, Switzerland
Mol Cell 13:125-35. 2004..Although not fully interchangeable during assistance of glycoprotein folding, calreticulin and calnexin may work, independently, as efficient and crucial factors for retention in the ER of nonnative polypeptides... - Cleavage of calnexin caused by apoptotic stimuli: implication for the regulation of apoptosisTakenori Takizawa
Department of Molecular Neurobiology, Institute for Developmental Research, Aichi Human Service Center, Kasugai 480 0392, Japan
J Biochem 136:399-405. 2004..These results collectively suggest that caspase-3 or caspase-7 cleaves calnexin, whose cleaved product leads to the attenuation of apoptosis... - Adaptation to ER stress is mediated by differential stabilities of pro-survival and pro-apoptotic mRNAs and proteinsD Thomas Rutkowski
Howard Hughes Medical Institute, University of Michigan Medical Center, Ann Arbor, Michigan, USA
PLoS Biol 4:e374. 2006..It underscores the contribution of posttranscriptional and posttranslational mechanisms in influencing this outcome... - Early postnatal death and motor disorders in mice congenitally deficient in calnexin expressionAngela Denzel
Imperial Cancer Research Fund, Academic Department of Histopathology, Bart s and the Queen Mary s School of Medicine and Dentistry, Whitechapel, United Kingdom
Mol Cell Biol 22:7398-404. 2002..Thus, the critical contribution of calnexin to mammalian physiology is tissue specific... - Growth of peripheral and central nervous system tumors is supported by cytoplasmic c-Fos in humans and miceDavid C Silvestre
Departamento de Quimica Biologica, Facultad de Ciencias Quimicas, CIQUIBIC, Universidad Nacional de Cordoba, Cordoba, Argentina
PLoS ONE 5:e9544. 2010..Herein we examined phospholipid synthesis status in brain tumors from human patients and from NPcis mice, an animal model of the human disease Neurofibromatosis Type 1 (NF1)... - The role of tapasin in MHC class I protein trafficking in embryos and T cellsPaula W Lampton
Department of Biology, 134 Mugar Hall, Northeastern University, Boston, MA 02115, USA
J Reprod Immunol 78:28-39. 2008..Identification of the molecules involved in regulation of MHC class I protein expression in early embryos is an important first step in gaining insight into mechanisms of escape of embryos from destruction by the maternal immune system... - Differentially expressed genes in embryonic cardiac tissues of mice lacking Folr1 gene activityHuiping Zhu
Center for Environmental and Genetic Medicine, Institute of Biosciences and Technology, Texas A and M University System Health Science Center, Houston, Texas 77030, USA
BMC Dev Biol 7:128. 2007..Defective function of the Folr1 (also known as Folbp1; homologue of human FRalpha) gene in mice results in inadequate transport, accumulation, or metabolism of folate during cardiovascular morphogenesis... - MARCKS-like protein, a membrane protein identified for its expression in developing neural retina, plays a role in regulating retinal cell proliferationJing Zhao
Department of Molecular and Developmental Biology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, 108 8639, Tokyo, Japan
Biochem J 408:51-9. 2007..Mutation analysis of MLP demonstrated that myristoylation was necessary to promote proliferation and that phosphorylation inhibited proliferation, indicating the functional importance of membrane localization... - Expression of the murine Pomt1 gene in both the developing brain and adult muscle tissues and its relationship with clinical aspects of Walker-Warburg syndromeBelén Prados
Department of Biochemistry, Instituto de Investigaciones Biomedicas Alberto Sols CSIC UAM, Facultad de Medicina, Universidad Autonoma de Madrid, 28029 Madrid, Spain
Am J Pathol 170:1659-68. 2007..This expression pattern in the testes could also be related to the gonadal anomalies observed in some patients with WWS... - Effects of endoplasmic reticulum stress on group VIA phospholipase A2 in beta cells include tyrosine phosphorylation and increased association with calnexinHaowei Song
Mass Spectrometry Resource, Division of Endocrinology, Metabolism, and Lipid Research, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Biol Chem 285:33843-57. 2010..Similar results were obtained with mouse pancreatic islets... - Altered vitamin A homeostasis and increased size and adiposity in the rdh1-null mouseMin Zhang
Nutritional Science and Toxicology, University of California, Berkeley, CA 94720 3104, USA
FASEB J 21:2886-96. 2007.... - Calumin, a novel Ca2+-binding transmembrane protein on the endoplasmic reticulumMiao Zhang
Department of Biological Chemistry, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606 8501, Japan
Cell Calcium 42:83-90. 2007..These observations suggest that calumin plays an essential role in ER Ca2+ handling and is also implicated in signaling from the ER, which is closely associated with cell-fate decision... 
Identification of heat shock protein 5, calnexin and integral membrane protein 2B as Adam7-interacting membrane proteins in mouse spermCecil Han
School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju, Korea
J Cell Physiol 226:1186-95. 2011..This analysis revealed that Adam7 forms complexes with calnexin (Canx), heat shock protein 5 (Hspa5), and integral membrane protein 2B (Itm2b)...- Enhanced clathrin-dependent endocytosis in the absence of calnexinHao Dong Li
Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada
PLoS ONE 6:e21678. 2011..The endoplasmic reticulum luminal domain of calnexin is responsible for lectin-like activity and interaction with nascent polypeptide chains. The role of the C-terminal, cytoplasmic portion of calnexin is not clear... - The coxsackie- and adenovirus receptor (CAR) is an in vivo marker for epithelial tight junctions, with a potential role in regulating permeability and tissue homeostasisElisabeth Raschperger
Ludwig Institute for Cancer Research, Nobels v 3, SE 171 77 Stockholm, Sweden
Exp Cell Res 312:1566-80. 2006..We conclude that CAR is localized to epithelial tight junctions in vivo where it may play a role in the regulation of epithelial permeability and tissue homeostasis... - Ttyh1, a Ca(2+)-binding protein localized to the endoplasmic reticulum, is required for early embryonic developmentTomohiro Kumada
Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan
Dev Dyn 239:2233-45. 2010..Our findings indicate that Ttyh1 plays an indispensable role during mitosis in early embryogenesis, possibly by maintaining Ca(2+) homeostasis in the ER... - Peptide-based interactions with calnexin target misassembled membrane proteins into endoplasmic reticulum-derived multilamellar bodiesVladimir M Korkhov
Institute of Pharmacology, Center of Biomolecular Medicine and Pharmacology, Medical University Vienna, Waehringer Strasse 13a, A 1090 Vienna, Austria
J Mol Biol 378:337-52. 2008..Our findings are consistent with a model in which the transmembrane segment of calnexin participates in chaperoning the inter- and intramolecular arrangement of hydrophobic segment in oligomeric proteins... - Lipidomic analysis and electron transport chain activities in C57BL/6J mouse brain mitochondriaMichael A Kiebish
Biology Department, Boston College, Chestnut Hill, Massachusetts 02467, USA
J Neurochem 106:299-312. 2008..NS and Syn mitochondrial lipidomic heterogeneity could influence energy metabolism, which may contribute to metabolic compartmentation of the brain... - Cyclophilin C-associated protein/Mac-2 binding protein colocalizes with calnexin and regulates the expression of tissue transglutaminaseWuyi Kong
Children s Surgical Research Program, Stanford University School of Medicine, Stanford, California 94305 5148, USA
J Cell Physiol 223:151-7. 2010..Our data give novel evidence that CyCAP regulates the post-translational modification of tTG through its colocalization with calnexin in ER... - The fibroblast growth factor receptor substrate 3 adapter is a developmentally regulated microtubule-associated protein expressed in migrating and differentiated neuronsTodd Hryciw
Molecular Brain Research Group, Robarts Research Institute, London, Ontario, Canada
J Neurochem 112:924-39. 2010..Collectively, these data suggest that neuronal Frs3 functions as a novel microtubule binding protein and they provide the first biochemical evidence that neuronal Frs3 is functionally distinct from Frs2/Frs2alpha... - Cloning of mouse ojoplano, a reticular cytoplasmic protein expressed during embryonic developmentFlorian Mertes
Max Planck Institute for Molecular Genetics, Berlin, Germany
Gene Expr Patterns 9:562-7. 2009..Opo shows homology to human transcripts linked to a hereditary craniofacial malformation, orofacial cleft 1 (OFC1). The expression of mouse Opo in neural crest derivatives and skull elements further supports this link... - ERp57 does not require interactions with calnexin and calreticulin to promote assembly of class I histocompatibility molecules, and it enhances peptide loading independently of its redox activityYinan Zhang
Departments of Biochemistry and Immunology, University of Toronto, Toronto M5S 1A8, Canada
J Biol Chem 284:10160-73. 2009..Thus, ERp57 appears to play a structural rather than catalytic role within the peptide loading complex... - Mitochondrial degeneration and not apoptosis is the primary cause of embryonic lethality in ceramide transfer protein mutant miceXin Wang
Laboratory of Cell and Developmental Signaling, National Cancer Institute at Frederick, Frederick, MD 21702, USA
J Cell Biol 184:143-58. 2009..Thus, global compromise of ER and mitochondrial integrity caused by ceramide accumulation in CERT mutant mice primarily affects organogenesis rather than causing cell death via apoptotic pathways... - Calnexin is not essential for mammalian rod opsin biogenesisMaria Kosmaoglou
UCL Institute of Ophthalmology, London, UK
Mol Vis 14:2466-74. 2008..A recent report has shown that Drosophila rhodopsin Rh1 requires calnexin (Cnx) for its maturation and correct localization to R1-6 rhabdomeres... - Mutational analysis of calnexinJody Groenendyk
Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada
Biochim Biophys Acta 1808:1435-40. 2011.... - Accessory proteins are vital for the functional expression of certain G protein-coupled receptorsSadani N Cooray
Centre for Endocrinology, William Harvey Research Institute, Barts and The London, London, UK
Mol Cell Endocrinol 300:17-24. 2009..Understanding their roles in GPCR expression would not only give us an insight into these receptors from a cell biological point of view but may also potentially lead to the development of novel therapeutics... - Targeted mutation of the mouse Grp94 gene disrupts development and perturbs endoplasmic reticulum stress signalingChanghui Mao
Department of Biochemistry and Molecular Biology, University of Southern California Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, California, USA
PLoS ONE 5:e10852. 2010..Furthermore, from analysis of microarray database and immunohistochemical staining, we present predictions where GRP94 may play an important role in specific adult organ homeostasis and function... - Role of calnexin in the ER quality control and productive folding of CFTR; differential effect of calnexin knockout on wild-type and DeltaF508 CFTRTsukasa Okiyoneda
Department of Molecular Medicine, Graduate School of Medical and Pharmaceutical Sciences, Global COE Cell Fate Regulation Research and Education Unit, Kumamoto University, Kumamoto 862 0973, Japan
Biochim Biophys Acta 1783:1585-94. 2008..Here, we show that calnexin (CNX) is not necessary for the ER retention of DeltaF508 CFTR... - Specialization of endoplasmic reticulum chaperones for the folding and function of myelin glycoproteins P0 and PMP22Joanna Jung
Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada
FASEB J 25:3929-37. 2011.... - Development of a deer mouse whole-genome radiation hybrid panel and comparative mapping of Mus chromosome 11 lociClifton M Ramsdell
Peromyscus Genetic Stock Center, Department of Biological Sciences, University of South Carolina, 700 Sumter Street, Columbia, South Carolina 29208, USA
Mamm Genome 17:37-48. 2006..Furthermore, this separate linkage group is likely to reside in a chromosomal region of inversion polymorphism between P. maniculatus and P. polionotus... - Association of calnexin with mutant peripheral myelin protein-22 ex vivo: a basis for "gain-of-function" ER diseasesK M Dickson
Department of Neurology and Neurosurgery, McGill University, 3640 University Street, Montreal, QC, Canada H3A 2B2
Proc Natl Acad Sci U S A 99:9852-7. 2002..approximately equal to 11 min), and oligosaccharide processing-dependent manner with the lectin chaperone calnexin (CNX), but not calreticulin nor BiP... - Localization of neutral ceramidase in caveolin-enriched light membranes of murine endothelial cellsE Romiti
Dipartimento di Scienze Biochimiche, Viale G B Morgagni 50, Florence, Italy
FEBS Lett 506:163-8. 2001..These findings suggest that neutral CDase is implicated, together with SMase activities, in the control of caveolar Cer content that may be critical for caveola dynamics... - Functional expression of the new gap junction gene connexin47 transcribed in mouse brain and spinal cord neuronsB Teubner
Institut fur Genetik, Universitat Bonn, D 53117 Bonn, Germany
J Neurosci 21:1117-26. 2001..Thus, electrical synapses in adult mammalian brain are likely to consist of different connexin proteins depending on the neuronal subtype... - Syntaxin 3 and Munc-18-2 in epithelial cells during kidney developmentS Lehtonen
Haartman Institute and Department of Pathology, University of Helsinki, Finland
Kidney Int 56:815-26. 1999..We have analyzed the expression patterns of vesicle-docking proteins of the syntaxin family in mouse kidney, focusing on syntaxin 3 and its interaction partner, the Sec1-related Munc-18-2... - Genes regulating MHC class I processing of antigenP M van Endert
INSERM U25 Hôpital Necker, Paris, France
Curr Opin Immunol 11:82-8. 1999..Finally, genetic evidence suggests an important influence of an unidentified gene, in the MHC complex, on MHC class I processing... - Protein interactions regulating vesicle transport between the endoplasmic reticulum and Golgi apparatus in mammalian cellsJ C Hay
Department of Molecular and Cellular Physiology, Stanford University School of Medicine, California 94305 5428, USA
Cell 89:149-58. 1997..We propose that these protein interactions determine vesicle docking/fusion fidelity between the endoplasmic reticulum and Golgi... - Natural resistance to infection with intracellular pathogens: the Nramp1 protein is recruited to the membrane of the phagosomeS Gruenheid
Department of Biochemistry, McGill University, Montreal, Quebec, Canada
J Exp Med 185:717-30. 1997.... - Involvement of the chaperone protein calnexin and the acetylcholine receptor beta-subunit in the assembly and cell surface expression of the receptorS H Keller
Department of Pharmacology 0636, University of California, San Diego, La Jolla, California 92093, USA
J Biol Chem 271:22871-7. 1996..Thus, calnexin appears to associate with the individual nascent subunits, thereby facilitating their assembly into the mature pentameric receptor... - Calnexin associates exclusively with individual CD3 delta and T cell antigen receptor (TCR) alpha proteins containing incompletely trimmed glycans that are not assembled into multisubunit TCR complexesJ E van Leeuwen
Experimental Immunology Branch, NCI, National Institutes of Health, Bethesda, Maryland 20892 1360, USA
J Biol Chem 271:9660-5. 1996..In addition, these data document that calnexin assembly with CD3 delta and TCR alpha glycoproteins involves both glycan-dependent and glycan-independent mechanisms... - Molecular cloning and sequencing of calnexin-t. An abundant male germ cell-specific calcium-binding protein of the endoplasmic reticulumS Ohsako
Department of Veterinary Biosciences, University of Illinois, Urbana 61801
J Biol Chem 269:14140-8. 1994..These results suggest that spermatogenic cell endoplasmic reticulum has a unique calcium binding protein, calnexin-t, which appears to be a calnexin variant... - Class II histocompatibility molecules associate with calnexin during assembly in the endoplasmic reticulumK L Schreiber
Department of Immunology, Mayo Clinic, Rochester, MN 55905
Int Immunol 6:101-11. 1994..The isolation of cDNA fragments encoding murine calnexin will allow us to further evaluate the functional consequences of calnexin-class II interaction... - Localization of three genes expressed in retina on mouse chromosome 11C A Kozak
National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA
Mamm Genome 6:142-4. 1995 - Aglycosylated and phosphatidylinositol-anchored MHC class I molecules are associated with calnexin. Evidence implicating the class I-connecting peptide segment in calnexin associationB M Carreno
Department of Genetics, Washington University School of Medicine, St Louis, MO 63110, USA
J Immunol 154:5173-80. 1995..These comparisons of Q7b isoforms implicate the class I-connecting peptide segment and not the transmembrane region as a site of interaction with calnexin... - Isolation and characterisation of a calnexin homologue, clxA, from Aspergillus nigerH Wang
Genencor International Inc, Palo Alto, CA 94304, USA
Mol Genet Genomics 268:684-91. 2003..Deletion studies indicate that clxA is not an essential gene in A. niger... - Presenilin 1 and presenilin 2 have differential effects on the stability and maturation of nicastrin in Mammalian brainFusheng Chen
Centre for Research in Neurodegenerative Diseases, Tanz Neuroscience Building, University of Toronto, Ontario M5S 3H2, Canada
J Biol Chem 278:19974-9. 2003..Our data therefore suggest that the differential interactions of PS1 and PS2 with nicastrin reflect different functions for the PS1 and PS2 complexes... - Platelet-derived growth factor D induces cardiac fibrosis and proliferation of vascular smooth muscle cells in heart-specific transgenic miceAnnica Pontén
Ludwig Institute for Cancer Research, S 17177 Stockholm, Sweden
Circ Res 97:1036-45. 2005..Our data raise the possibility that this growth factor may be involved in cardiac fibrosis and atherosclerosis... - Intracellular lipidation of newly synthesized apolipoprotein A-I in primary murine hepatocytesJovana Maric
Lipoprotein and Atherosclerosis Research Group, University of Ottawa Heart Institute, Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, Ontario K1Y 4W7, Canada
J Biol Chem 280:39942-9. 2005..Kiss, R. S., Franklin, V., Wang, M. D., Haidar, B., and Marcel, Y. L. (2005) J. Biol. Chem. 280, 21612-21621) occurs after secretion at the cell surface... - Calnexin and ERp57 facilitate the assembly of the neonatal Fc receptor for IgG with beta 2-microglobulin in the endoplasmic reticulumXiaoping Zhu
Laboratory of Immunology, Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, 8075 Greenmead Drive, College Park, MD 20742, USA
J Immunol 175:967-76. 2005..Mass spectrometry analysis revealed that this band was identical with calnexin (CNX)... - Soluble tyrosinase is an endoplasmic reticulum (ER)-associated degradation substrate retained in the ER by calreticulin and BiP/GRP78 and not calnexinCostin I Popescu
Institute of Biochemistry, Splaiul Independentei 296, 060031 Bucharest 17, Romania
J Biol Chem 280:13833-40. 2005..The lack of specificity for calnexin interaction reveals a novel role for calreticulin in OCAI albinism... - Vasohibin as an endothelium-derived negative feedback regulator of angiogenesisKazuhide Watanabe
Department of Vascular Biology, Institute of Development, Aging, and Cancer, Tohoku University, Sendai, Japan
J Clin Invest 114:898-907. 2004..We propose vasohibin to be an endothelium-derived negative feedback regulator of angiogenesis... - The molecular chaperone calnexin is expressed on the surface of immature thymocytes in association with clonotype-independent CD3 complexesD L Wiest
Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
EMBO J 14:3425-33. 1995.... - Presenilin 1 mediates the turnover of telencephalin in hippocampal neurons via an autophagic degradative pathwayCary Esselens
Membrane Trafficking Laboratory, CME VIB04, Gasthuisberg KU Leuven, 3000 Leuven, Belgium
J Cell Biol 166:1041-54. 2004..Collectively, PS1 deficiency affects in a gamma-secretase-independent fashion the turnover of TLN through autophagic vacuoles, most likely by an impaired capability to fuse with lysosomes... - Substrate-specific requirements for UGT1-dependent release from calnexinTatiana Soldà
Institute for Research in Biomedicine, Bellinzona, Switzerland
Mol Cell 27:238-49. 2007..For other proteins, UGT1 deletion substantially delays release from calnexin, unexpectedly showing that UGT1 activity might be required for a structural maturation needed for substrate dissociation from calnexin and export from the ER... - Both raft- and non-raft proteins associate with CHAPS-insoluble complexes: some APP in large complexesAlexander Rouvinski
Department of Molecular Biology, The Hebrew University Hadassah Medical School, P O Box 12272, Jerusalem 91120, Israel
Biochem Biophys Res Commun 308:750-8. 2003..Large CHAPS-insoluble complexes resemble, but are not equal to, classical rafts. These findings extend considerably the range of detergent-insoluble membranal domains... - Role of calnexin in the glycan-independent quality control of proteolipid proteinEileithyia Swanton
School of Biological Sciences, University of Manchester, 2 205 Stopford Building, Oxford Road, Manchester M13 9PT, UK
EMBO J 22:2948-58. 2003.... - Compromised calnexin function in calreticulin-deficient cellsRai Knee
Department of Biochemistry, Canadian Institutes of Health Research Membrane Protein Research Group, University of Alberta, Edmonton, Alberta, Canada T6G 2H7
Biochem Biophys Res Commun 304:661-6. 2003..We show that the absence of calreticulin can have devastating effects on the function of the others, compromising overall quality control of the secretory pathway and activating UPR-dependent pathways... - Endoplasmic reticulum stress during the embryonic development of the central nervous system in the mouseXiaochu Zhang
Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
Int J Dev Neurosci 25:455-63. 2007..Furthermore, our data suggest that ER stress-like mechanism may induce apoptosis via activation of the caspases during embryonic development of the central nervous system... - Retention of unassembled components of integral membrane proteins by calnexinS Rajagopalan
Department of Rheumatology and Immunology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115
Science 263:387-90. 1994..Since engineered calnexin determined the intracellular localization of the proteins associated with it, it is concluded that calnexin interacts with incompletely assembled TCR components and retains them in the ER... - A predominant role of acyl-CoA:monoacylglycerol acyltransferase-2 in dietary fat absorption implicated by tissue distribution, subcellular localization, and up-regulation by high fat dietJingsong Cao
Division of Endocrine Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
J Biol Chem 279:18878-86. 2004..Taken together, our data suggest a predominant role of MGAT2 in dietary fat absorption... - A novel cardiolipin-remodeling pathway revealed by a gene encoding an endoplasmic reticulum-associated acyl-CoA:lysocardiolipin acyltransferase (ALCAT1) in mouseJingsong Cao
Endocrine Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
J Biol Chem 279:31727-34. 2004..ALCAT1 represents the first identified cardiolipin-remodeling enzyme from any living organism; its identification implies a novel role for the endoplasmic reticulum in cardiolipin metabolism...