Gene Symbol: Canx
Description: calnexin
Alias: 1110069N15Rik, AI988026, Cnx, D11Ertd153e, calnexin
Species: mouse
Products:     Canx

Top Publications

  1. Kraus A, Groenendyk J, Bedard K, Baldwin T, Krause K, Dubois Dauphin M, et al. Calnexin deficiency leads to dysmyelination. J Biol Chem. 2010;285:18928-38 pubmed publisher
    b>Calnexin is a molecular chaperone and a component of the quality control of the secretory pathway. We have generated calnexin gene-deficient mice (cnx(-/-)) and showed that calnexin deficiency leads to myelinopathy...
  2. Tjoelker L, Seyfried C, Eddy R, Byers M, Shows T, Calderon J, et al. Human, mouse, and rat calnexin cDNA cloning: identification of potential calcium binding motifs and gene localization to human chromosome 5. Biochemistry. 1994;33:3229-36 pubmed
    b>Calnexin is a 90-kDa integral membrane protein of the endoplasmic reticulum (ER). Calnexin binds Ca2+ and may function as a chaperone in the transition of proteins from the ER to the outer cellular membrane...
  3. Bergeron J, Brenner M, Thomas D, Williams D. Calnexin: a membrane-bound chaperone of the endoplasmic reticulum. Trends Biochem Sci. 1994;19:124-8 pubmed
    b>Calnexin is a new type of molecular chaperone that interacts with many nascent membrane and soluble proteins of the secretory pathway...
  4. Molinari M, Eriksson K, Calanca V, Galli C, Cresswell P, Michalak M, et al. Contrasting functions of calreticulin and calnexin in glycoprotein folding and ER quality control. Mol Cell. 2004;13:125-35 pubmed
    Calreticulin and calnexin are homologous lectins that serve as molecular chaperones for glycoproteins in the endoplasmic reticulum of eukaryotic cells...
  5. Takizawa T, Tatematsu C, Watanabe K, Kato K, Nakanishi Y. Cleavage of calnexin caused by apoptotic stimuli: implication for the regulation of apoptosis. J Biochem. 2004;136:399-405 pubmed
    b>Calnexin is an endoplasmic reticulum (ER)-resident molecular chaperone that plays an essential role in the correct folding of membrane proteins. We found that calnexin is subjected to partial cleavage in apoptotic mouse cells...
  6. Denzel A, Molinari M, Trigueros C, Martin J, Velmurgan S, Brown S, et al. Early postnatal death and motor disorders in mice congenitally deficient in calnexin expression. Mol Cell Biol. 2002;22:7398-404 pubmed
    b>Calnexin is a ubiquitously expressed type I membrane protein which is exclusively localized in the endoplasmic reticulum (ER)...
  7. Williams D. Beyond lectins: the calnexin/calreticulin chaperone system of the endoplasmic reticulum. J Cell Sci. 2006;119:615-23 pubmed
    b>Calnexin and calreticulin are related proteins that comprise an ER chaperone system that ensures the proper folding and quality control of newly synthesized glycoproteins...
  8. Coe H, Bedard K, Groenendyk J, Jung J, Michalak M. Endoplasmic reticulum stress in the absence of calnexin. Cell Stress Chaperones. 2008;13:497-507 pubmed publisher
    b>Calnexin is a type I integral endoplasmic reticulum (ER) membrane chaperone involved in folding of newly synthesized (glycol)proteins...
  9. Luo S, Mao C, Lee B, Lee A. GRP78/BiP is required for cell proliferation and protecting the inner cell mass from apoptosis during early mouse embryonic development. Mol Cell Biol. 2006;26:5688-97 pubmed
    ..These findings provide the first evidence that GRP78 is essential for embryonic cell growth and pluripotent cell survival. ..

More Information


  1. Rutkowski D, Arnold S, Miller C, Wu J, Li J, Gunnison K, et al. Adaptation to ER stress is mediated by differential stabilities of pro-survival and pro-apoptotic mRNAs and proteins. PLoS Biol. 2006;4:e374 pubmed
    ..It underscores the contribution of posttranscriptional and posttranslational mechanisms in influencing this outcome. ..
  2. Hay J, Chao D, Kuo C, Scheller R. Protein interactions regulating vesicle transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells. Cell. 1997;89:149-58 pubmed
    ..We propose that these protein interactions determine vesicle docking/fusion fidelity between the endoplasmic reticulum and Golgi. ..
  3. Swanton E, High S, Woodman P. Role of calnexin in the glycan-independent quality control of proteolipid protein. EMBO J. 2003;22:2948-58 pubmed
    ..A glycoprotein-specific system involving the ER lectins calnexin and calreticulin is well documented, but very little is known about mechanisms that may operate for non-..
  4. Prior K, Wittig I, Leisegang M, Groenendyk J, Weissmann N, Michalak M, et al. The Endoplasmic Reticulum Chaperone Calnexin Is a NADPH Oxidase NOX4 Interacting Protein. J Biol Chem. 2016;291:7045-59 pubmed publisher
    ..By this technique, several interacting proteins were identified with calnexin showing the most robust interaction...
  5. Carreno B, Schreiber K, McKean D, Stroynowski I, Hansen T. Aglycosylated and phosphatidylinositol-anchored MHC class I molecules are associated with calnexin. Evidence implicating the class I-connecting peptide segment in calnexin association. J Immunol. 1995;154:5173-80 pubmed
    The endoplasmic reticulum resident protein calnexin interacts with several glycoproteins including class I MHC molecules...
  6. Arribas González E, Alonso Torres P, Aragón C, López Corcuera B. Calnexin-assisted biogenesis of the neuronal glycine transporter 2 (GlyT2). PLoS ONE. 2013;8:e63230 pubmed publisher
    ..In this study we examined several aspects of GlyT2 biogenesis that involve the endoplasmic reticulum chaperone calnexin (CNX)...
  7. Korkhov V, Milan Lobo L, Zuber B, Farhan H, Schmid J, Freissmuth M, et al. Peptide-based interactions with calnexin target misassembled membrane proteins into endoplasmic reticulum-derived multilamellar bodies. J Mol Biol. 2008;378:337-52 pubmed publisher
    ..GAT1-E101D, we showed here that ER retention was due to association of the transporter with the ER chaperone calnexin: interaction with calnexin led to accumulation of GAT1 in concentric bodies corresponding to previously described ..
  8. Tsukuba T, Kadowaki T, Hengst J, Bond J. Chaperone interactions of the metalloproteinase meprin A in the secretory or proteasomal-degradative pathway. Arch Biochem Biophys. 2002;397:191-8 pubmed
    ..Both wild-type meprin alpha and the DeltaMAM mutant interact with the molecular chaperones calnexin and calreticulin in the endoplasmic reticulum...
  9. Ramsdell C, Thames E, Weston J, Dewey M. Development of a deer mouse whole-genome radiation hybrid panel and comparative mapping of Mus chromosome 11 loci. Mamm Genome. 2006;17:37-48 pubmed
    ..Furthermore, this separate linkage group is likely to reside in a chromosomal region of inversion polymorphism between P. maniculatus and P. polionotus. ..
  10. Cooray S, Chan L, Webb T, Metherell L, Clark A. Accessory proteins are vital for the functional expression of certain G protein-coupled receptors. Mol Cell Endocrinol. 2009;300:17-24 pubmed publisher
    ..Understanding their roles in GPCR expression would not only give us an insight into these receptors from a cell biological point of view but may also potentially lead to the development of novel therapeutics. ..
  11. Cantù C, Pagella P, Shajiei T, Zimmerli D, Valenta T, Hausmann G, et al. A cytoplasmic role of Wnt/?-catenin transcriptional cofactors Bcl9, Bcl9l, and Pygopus in tooth enamel formation. Sci Signal. 2017;10: pubmed publisher
  12. Watanabe K, Hasegawa Y, Yamashita H, Shimizu K, Ding Y, Abe M, et al. Vasohibin as an endothelium-derived negative feedback regulator of angiogenesis. J Clin Invest. 2004;114:898-907 pubmed
    ..We propose vasohibin to be an endothelium-derived negative feedback regulator of angiogenesis. ..
  13. Shiwaku H, Yoshimura N, Tamura T, Sone M, Ogishima S, Watase K, et al. Suppression of the novel ER protein Maxer by mutant ataxin-1 in Bergman glia contributes to non-cell-autonomous toxicity. EMBO J. 2010;29:2446-60 pubmed publisher
    ..Collectively, these results suggest that the reduction of Maxer mediates functional deficiency of Bergmann glia, and might contribute to the non-cell-autonomous pathology of SCA1. ..
  14. Rajagopalan S, Xu Y, Brenner M. Retention of unassembled components of integral membrane proteins by calnexin. Science. 1994;263:387-90 pubmed
    ..The molecular chaperone function of calnexin (IP90, p88), a 90-kilodalton protein that resides in the endoplasmic reticulum (ER), in the retention of ..
  15. Hryciw T, MacDonald J, Phillips R, Seah C, Pasternak S, Meakin S. The fibroblast growth factor receptor substrate 3 adapter is a developmentally regulated microtubule-associated protein expressed in migrating and differentiated neurons. J Neurochem. 2010;112:924-39 pubmed publisher
    ..Collectively, these data suggest that neuronal Frs3 functions as a novel microtubule binding protein and they provide the first biochemical evidence that neuronal Frs3 is functionally distinct from Frs2/Frs2alpha. ..
  16. Soldà T, Galli C, Kaufman R, Molinari M. Substrate-specific requirements for UGT1-dependent release from calnexin. Mol Cell. 2007;27:238-49 pubmed
    ..synthesized glycoproteins displaying monoglucosylated N-glycans bind to the endoplasmic reticulum (ER) chaperone calnexin, and their maturation is catalyzed by the calnexin-associated oxidoreductase ERp57...
  17. Wang X, Rao R, Kosakowska Cholody T, Masood M, Southon E, Zhang H, et al. Mitochondrial degeneration and not apoptosis is the primary cause of embryonic lethality in ceramide transfer protein mutant mice. J Cell Biol. 2009;184:143-58 pubmed publisher
    ..Thus, global compromise of ER and mitochondrial integrity caused by ceramide accumulation in CERT mutant mice primarily affects organogenesis rather than causing cell death via apoptotic pathways. ..
  18. Kumada T, Yamanaka Y, Kitano A, Shibata M, Awaya T, Kato T, et al. Ttyh1, a Ca(2+)-binding protein localized to the endoplasmic reticulum, is required for early embryonic development. Dev Dyn. 2010;239:2233-45 pubmed publisher
    ..Our findings indicate that Ttyh1 plays an indispensable role during mitosis in early embryogenesis, possibly by maintaining Ca(2+) homeostasis in the ER. ..
  19. Zhang Y, Kozlov G, Pocanschi C, Brockmeier U, Ireland B, Maattanen P, et al. ERp57 does not require interactions with calnexin and calreticulin to promote assembly of class I histocompatibility molecules, and it enhances peptide loading independently of its redox activity. J Biol Chem. 2009;284:10160-73 pubmed publisher
    ..Since ERp57 associates with the lectin chaperones calnexin and calreticulin, it is thought that ERp57 requires these chaperones to gain access to its substrates...
  20. Patra D, DeLassus E, Liang G, Sandell L. Cartilage-specific ablation of site-1 protease in mice results in the endoplasmic reticulum entrapment of type IIb procollagen and down-regulation of cholesterol and lipid homeostasis. PLoS ONE. 2014;9:e105674 pubmed publisher
    ..This role appears not to be related to lipid pathways or other current known functions of S1P and is likely dependent on additional, yet unknown, S1P substrates in chondrocytes. ..
  21. Itakura M, Tsujimura J, Yamamori S, Ohkido T, Takahashi M. NMDA receptor-dependent recruitment of calnexin to the neuronal plasma membrane. Neurosci Lett. 2013;550:173-8 pubmed publisher
    b>Calnexin is a molecular chaperone that resides in the endoplasmic reticulum and participates in the folding and assembly of nascent proteins...
  22. Chen F, Tandon A, Sanjo N, Gu Y, Hasegawa H, Arawaka S, et al. Presenilin 1 and presenilin 2 have differential effects on the stability and maturation of nicastrin in Mammalian brain. J Biol Chem. 2003;278:19974-9 pubmed
    ..Our data therefore suggest that the differential interactions of PS1 and PS2 with nicastrin reflect different functions for the PS1 and PS2 complexes. ..
  23. Song H, Rohrs H, Tan M, Wohltmann M, Ladenson J, Turk J. Effects of endoplasmic reticulum stress on group VIA phospholipase A2 in beta cells include tyrosine phosphorylation and increased association with calnexin. J Biol Chem. 2010;285:33843-57 pubmed publisher
    ..They include the ER chaperone calnexin, whose association with iPLA(2)? increases upon induction of ER stress...
  24. Zhao J, Izumi T, Nunomura K, Satoh S, Watanabe S. MARCKS-like protein, a membrane protein identified for its expression in developing neural retina, plays a role in regulating retinal cell proliferation. Biochem J. 2007;408:51-9 pubmed
    ..Mutation analysis of MLP demonstrated that myristoylation was necessary to promote proliferation and that phosphorylation inhibited proliferation, indicating the functional importance of membrane localization. ..
  25. Romiti E, Meacci E, Tanzi G, Becciolini L, Mitsutake S, Farnararo M, et al. Localization of neutral ceramidase in caveolin-enriched light membranes of murine endothelial cells. FEBS Lett. 2001;506:163-8 pubmed
    ..These findings suggest that neutral CDase is implicated, together with SMase activities, in the control of caveolar Cer content that may be critical for caveola dynamics. ..
  26. Dickson K, Bergeron J, Shames I, Colby J, Nguyen D, Chevet E, et al. Association of calnexin with mutant peripheral myelin protein-22 ex vivo: a basis for "gain-of-function" ER diseases. Proc Natl Acad Sci U S A. 2002;99:9852-7 pubmed
    ..approximately equal to 11 min), and oligosaccharide processing-dependent manner with the lectin chaperone calnexin (CNX), but not calreticulin nor BiP...
  27. Li H, Liu W, Michalak M. Enhanced clathrin-dependent endocytosis in the absence of calnexin. PLoS ONE. 2011;6:e21678 pubmed publisher
    b>Calnexin, together with calreticulin, constitute the calnexin/calreticulin cycle...
  28. Popescu C, Paduraru C, Dwek R, Petrescu S. Soluble tyrosinase is an endoplasmic reticulum (ER)-associated degradation substrate retained in the ER by calreticulin and BiP/GRP78 and not calnexin. J Biol Chem. 2005;280:13833-40 pubmed
    ..experiments showed that soluble tyrosinase interacts with calreticulin and BiP/GRP78 (and not calnexin) during its ER transit...
  29. Tokuhiro K, Satouh Y, Nozawa K, Isotani A, Fujihara Y, Hirashima Y, et al. Calreticulin is required for development of the cumulus oocyte complex and female fertility. Sci Rep. 2015;5:14254 pubmed publisher
    b>Calnexin (CANX) and calreticulin (CALR) chaperones mediate nascent glycoprotein folding in the endoplasmic reticulum. Here we report that these chaperones have distinct roles in male and female fertility...
  30. Keller S, Lindstrom J, Taylor P. Involvement of the chaperone protein calnexin and the acetylcholine receptor beta-subunit in the assembly and cell surface expression of the receptor. J Biol Chem. 1996;271:22871-7 pubmed
    ..In addition, we determined that the chaperone protein calnexin is associated with the isolated alpha-, beta-, and delta-subunits of the receptor, but calnexin is not detected ..
  31. Valente P, Castroflorio E, Rossi P, Fadda M, Sterlini B, Cervigni R, et al. PRRT2 Is a Key Component of the Ca(2+)-Dependent Neurotransmitter Release Machinery. Cell Rep. 2016;15:117-131 pubmed publisher
    ..The results indicate that PRRT2 is intimately connected with the Ca(2+)-sensing machinery and that it plays an important role in the final steps of neurotransmitter release. ..
  32. Kupershmidt S, Yang I, Hayashi K, Wei J, Chanthaphaychith S, Petersen C, et al. The IKr drug response is modulated by KCR1 in transfected cardiac and noncardiac cell lines. FASEB J. 2003;17:2263-5 pubmed
    ..We propose that KCR1, when coupled to HERG, may limit the sensitivity of HERG to proarrhythmic drug blockade and may be a rational target for modifying the proarrhythmic effects of otherwise clinically useful compounds. ..
  33. Wei F, Suzuki T, Watanabe S, Kimura S, Kaitsuka T, Fujimura A, et al. Deficit of tRNA(Lys) modification by Cdkal1 causes the development of type 2 diabetes in mice. J Clin Invest. 2011;121:3598-608 pubmed publisher
    ..These findings suggest that glucose-stimulated translation of proinsulin may require fully modified tRNA(Lys)(UUU), which could potentially explain the molecular pathogenesis of T2D in patients carrying cdkal1 risk alleles. ..
  34. Rouvinski A, Gahali Sass I, Stav I, Metzer E, Atlan H, Taraboulos A. Both raft- and non-raft proteins associate with CHAPS-insoluble complexes: some APP in large complexes. Biochem Biophys Res Commun. 2003;308:750-8 pubmed
    ..In contrast, with the zwitterionic detergent CHAPS, non-raft residents such as calnexin and APP also buoyed...
  35. Knee R, Ahsan I, Mesaeli N, Kaufman R, Michalak M. Compromised calnexin function in calreticulin-deficient cells. Biochem Biophys Res Commun. 2003;304:661-6 pubmed
    b>Calnexin and calreticulin are molecular chaperones, which are involved in the protein folding, assembly, and retention/retrieval...
  36. Tominaga K, Kondo C, Kagata T, Hishida T, Nishizuka M, Imagawa M. The novel gene fad158, having a transmembrane domain and leucine-rich repeat, stimulates adipocyte differentiation. J Biol Chem. 2004;279:34840-8 pubmed
    ..fad158 has the ability to regulate adipocyte differentiation positively, especially at an early stage. ..
  37. Lampton P, Goldstein C, Warner C. The role of tapasin in MHC class I protein trafficking in embryos and T cells. J Reprod Immunol. 2008;78:28-39 pubmed
    ..Here, we report the detection of mRNA for four chaperone molecules (TAP1, TAP2, calnexin and tapasin) in preimplantation embryos...
  38. Teubner B, Odermatt B, Guldenagel M, Sohl G, Degen J, Bukauskas F, et al. Functional expression of the new gap junction gene connexin47 transcribed in mouse brain and spinal cord neurons. J Neurosci. 2001;21:1117-26 pubmed
    ..Thus, electrical synapses in adult mammalian brain are likely to consist of different connexin proteins depending on the neuronal subtype. ..
  39. Zhu X, Peng J, Chen D, Liu X, Ye L, Iijima H, et al. Calnexin and ERp57 facilitate the assembly of the neonatal Fc receptor for IgG with beta 2-microglobulin in the endoplasmic reticulum. J Immunol. 2005;175:967-76 pubmed
    ..Mass spectrometry analysis revealed that this band was identical with calnexin (CNX)...
  40. Prados B, Peña A, Cotarelo R, Valero M, Cruces J. Expression of the murine Pomt1 gene in both the developing brain and adult muscle tissues and its relationship with clinical aspects of Walker-Warburg syndrome. Am J Pathol. 2007;170:1659-68 pubmed
    ..This expression pattern in the testes could also be related to the gonadal anomalies observed in some patients with WWS. ..
  41. Pontén A, Folestad E, Pietras K, Eriksson U. Platelet-derived growth factor D induces cardiac fibrosis and proliferation of vascular smooth muscle cells in heart-specific transgenic mice. Circ Res. 2005;97:1036-45 pubmed
    ..Our data raise the possibility that this growth factor may be involved in cardiac fibrosis and atherosclerosis. ..
  42. Wang H, Entwistle J, Morlon E, Archer D, Peberdy J, Ward M, et al. Isolation and characterisation of a calnexin homologue, clxA, from Aspergillus niger. Mol Genet Genomics. 2003;268:684-91 pubmed
    We describe the isolation of a gene (clxA) encoding calnexin from laboratory and industrial strains of Aspergillus niger...
  43. Raschperger E, Thyberg J, Pettersson S, Philipson L, Fuxe J, Pettersson R. The coxsackie- and adenovirus receptor (CAR) is an in vivo marker for epithelial tight junctions, with a potential role in regulating permeability and tissue homeostasis. Exp Cell Res. 2006;312:1566-80 pubmed
    ..We conclude that CAR is localized to epithelial tight junctions in vivo where it may play a role in the regulation of epithelial permeability and tissue homeostasis. ..
  44. Zong W, Li C, Hatzivassiliou G, Lindsten T, Yu Q, Yuan J, et al. Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis. J Cell Biol. 2003;162:59-69 pubmed
    ..These findings demonstrate that in addition to their functions at mitochondria, Bax and Bak also localize to the ER and function to initiate a parallel pathway of caspase activation and apoptosis. ..
  45. Zhu H, Cabrera R, Wlodarczyk B, Bozinov D, Wang D, Schwartz R, et al. Differentially expressed genes in embryonic cardiac tissues of mice lacking Folr1 gene activity. BMC Dev Biol. 2007;7:128 pubmed
    ..These changes affected normal cytoskeleton structures, cell migration and motility as well as cellular redox status, which may contribute to cardiovascular abnormalities in mouse embryos lacking Folr1 gene activity. ..
  46. Esselens C, Oorschot V, Baert V, Raemaekers T, Spittaels K, Serneels L, et al. Presenilin 1 mediates the turnover of telencephalin in hippocampal neurons via an autophagic degradative pathway. J Cell Biol. 2004;166:1041-54 pubmed
    ..Collectively, PS1 deficiency affects in a gamma-secretase-independent fashion the turnover of TLN through autophagic vacuoles, most likely by an impaired capability to fuse with lysosomes. ..
  47. Kuang E, Okumura C, Sheffy Levin S, Varsano T, Shu V, Qi J, et al. Regulation of ATG4B stability by RNF5 limits basal levels of autophagy and influences susceptibility to bacterial infection. PLoS Genet. 2012;8:e1003007 pubmed publisher
    ..Collectively, the RNF5-mediated control of membranalATG4B reveals a novel layer in the regulation of LC3 processing and autophagy. ..
  48. Jung J, Coe H, Michalak M. Specialization of endoplasmic reticulum chaperones for the folding and function of myelin glycoproteins P0 and PMP22. FASEB J. 2011;25:3929-37 pubmed publisher
    ..b>Calnexin, calreticulin, and ERp57 are critical components of protein quality control responsible for proper folding of ..
  49. Jung J, Michalak M. Cell surface targeting of myelin oligodendrocyte glycoprotein (MOG) in the absence of endoplasmic reticulum molecular chaperones. Biochim Biophys Acta. 2011;1813:1105-10 pubmed publisher
    ..b>Calnexin, calreticulin, and ERp57 are essential components of the endoplasmic reticulum quality control where they assist ..
  50. Han C, Park I, Lee B, Jin S, Choi H, Kwon J, et al. Identification of heat shock protein 5, calnexin and integral membrane protein 2B as Adam7-interacting membrane proteins in mouse sperm. J Cell Physiol. 2011;226:1186-95 pubmed publisher
    ..This analysis revealed that Adam7 forms complexes with calnexin (Canx), heat shock protein 5 (Hspa5), and integral membrane protein 2B (Itm2b)...
  51. Hume A, Collinson L, Rapak A, Gomes A, Hopkins C, Seabra M. Rab27a regulates the peripheral distribution of melanosomes in melanocytes. J Cell Biol. 2001;152:795-808 pubmed
  52. Kiebish M, Han X, Cheng H, Lunceford A, Clarke C, Moon H, et al. Lipidomic analysis and electron transport chain activities in C57BL/6J mouse brain mitochondria. J Neurochem. 2008;106:299-312 pubmed publisher
    ..NS and Syn mitochondrial lipidomic heterogeneity could influence energy metabolism, which may contribute to metabolic compartmentation of the brain. ..
  53. Mertes F, Martinez Morales J, Nolden T, Spörle R, Wittbrodt J, Lehrach H, et al. Cloning of mouse ojoplano, a reticular cytoplasmic protein expressed during embryonic development. Gene Expr Patterns. 2009;9:562-7 pubmed publisher
    ..Opo shows homology to human transcripts linked to a hereditary craniofacial malformation, orofacial cleft 1 (OFC1). The expression of mouse Opo in neural crest derivatives and skull elements further supports this link. ..
  54. Kosmaoglou M, Cheetham M. Calnexin is not essential for mammalian rod opsin biogenesis. Mol Vis. 2008;14:2466-74 pubmed
    ..A recent report has shown that Drosophila rhodopsin Rh1 requires calnexin (Cnx) for its maturation and correct localization to R1-6 rhabdomeres...
  55. van Endert P. Genes regulating MHC class I processing of antigen. Curr Opin Immunol. 1999;11:82-8 pubmed
    ..Finally, genetic evidence suggests an important influence of an unidentified gene, in the MHC complex, on MHC class I processing...
  56. Urresti J, Ruiz Meana M, Coccia E, Arévalo J, Castellano J, Fernández Sanz C, et al. Lifeguard Inhibits Fas Ligand-mediated Endoplasmic Reticulum-Calcium Release Mandatory for Apoptosis in Type II Apoptotic Cells. J Biol Chem. 2016;291:1221-34 pubmed publisher
    ..On the basis of our observations, we propose that there is a required step in the induction of type II apoptotic cell death that involves calcium mobilization from the ER and that this step is modulated by LFG. ..
  57. Cao J, Liu Y, Lockwood J, Burn P, Shi Y. A novel cardiolipin-remodeling pathway revealed by a gene encoding an endoplasmic reticulum-associated acyl-CoA:lysocardiolipin acyltransferase (ALCAT1) in mouse. J Biol Chem. 2004;279:31727-34 pubmed
    ..ALCAT1 represents the first identified cardiolipin-remodeling enzyme from any living organism; its identification implies a novel role for the endoplasmic reticulum in cardiolipin metabolism. ..
  58. Okiyoneda T, Niibori A, Harada K, Kohno T, Michalak M, Duszyk M, et al. Role of calnexin in the ER quality control and productive folding of CFTR; differential effect of calnexin knockout on wild-type and DeltaF508 CFTR. Biochim Biophys Acta. 2008;1783:1585-94 pubmed publisher
    ..Here, we show that calnexin (CNX) is not necessary for the ER retention of DeltaF508 CFTR...
  59. Lehtonen S, Riento K, Olkkonen V, Lehtonen E. Syntaxin 3 and Munc-18-2 in epithelial cells during kidney development. Kidney Int. 1999;56:815-26 pubmed
    ..The results show that Munc-18-2 and syntaxin 3 form a complex in vivo and suggest that they participate in epithelial cell differentiation and targeted vesicle transport processes in the developing kidney. ..
  60. Quiel A, Jürgen B, Greinacher A, Lassen S, Wörl R, Witt S, et al. Sensitive detection of idiotypic platelet-reactive alloantibodies by an electrical protein chip. Biosens Bioelectron. 2012;36:207-11 pubmed publisher
    ..With this electrical chip assay it is possible to detect antibodies against HPA-1a, HPA-5b and HLA with high sensitivity and specificity in less than half the duration of the MAIPA protocol with similar intra- and interassay variance. ..
  61. Zhang M, Hu P, Krois C, KANE M, Napoli J. Altered vitamin A homeostasis and increased size and adiposity in the rdh1-null mouse. FASEB J. 2007;21:2886-96 pubmed
  62. Kamhi Nesher S, Shenkman M, Tolchinsky S, Fromm S, Ehrlich R, Lederkremer G. A novel quality control compartment derived from the endoplasmic reticulum. Mol Biol Cell. 2001;12:1711-23 pubmed
    ..In the presence of proteasomal inhibitors, the ER chaperones calreticulin and calnexin, but not BiP, PDI, or glycoprotein glucosyltransferase, concentrate in the subcellular region of the novel ..
  63. Mao C, Wang M, Luo B, Wey S, Dong D, Wesselschmidt R, et al. Targeted mutation of the mouse Grp94 gene disrupts development and perturbs endoplasmic reticulum stress signaling. PLoS ONE. 2010;5:e10852 pubmed publisher
    ..Grp94 heterozygosity, complete knockout of GRP94 leads to compensatory upregulation of the ER chaperones GRP78, calnexin and calreticulin but not protein disulphide isomerase...
  64. Gruenheid S, Pinner E, Desjardins M, Gros P. Natural resistance to infection with intracellular pathogens: the Nramp1 protein is recruited to the membrane of the phagosome. J Exp Med. 1997;185:717-30 pubmed
  65. Cao J, Shan D, Revett T, Li D, Wu L, Liu W, et al. Molecular identification of a novel mammalian brain isoform of acyl-CoA:lysophospholipid acyltransferase with prominent ethanolamine lysophospholipid acylating activity, LPEAT2. J Biol Chem. 2008;283:19049-57 pubmed publisher
    ..These findings identify LPEAT2 as an important enzyme in the biosynthesis of ethanolamine-containing phospholipids, especially in brain. ..
  66. Bousette N, Abbasi C, Chis R, Gramolini A. Calnexin silencing in mouse neonatal cardiomyocytes induces Ca2+ cycling defects, ER stress, and apoptosis. J Cell Physiol. 2014;229:374-83 pubmed publisher
    b>Calnexin (CNX) is an endoplasmic reticulum (ER) quality control chaperone that has been implicated in ER stress. ER stress is a prominent pathological feature of various pathologic conditions, including cardiovascular diseases...
  67. Lang S, Benedix J, Fedeles S, Schorr S, Schirra C, Schäuble N, et al. Different effects of Sec61?, Sec62 and Sec63 depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cells. J Cell Sci. 2012;125:1958-69 pubmed publisher
    ..By contrast, silencing the SEC62 gene inhibited only post-translational transport of a signal-peptide-containing precursor protein. ..
  68. Maric J, Kiss R, Franklin V, Marcel Y. Intracellular lipidation of newly synthesized apolipoprotein A-I in primary murine hepatocytes. J Biol Chem. 2005;280:39942-9 pubmed
    ..Kiss, R. S., Franklin, V., Wang, M. D., Haidar, B., and Marcel, Y. L. (2005) J. Biol. Chem. 280, 21612-21621) occurs after secretion at the cell surface...
  69. Zhou T, Li J, Zhao P, Liu H, Jia D, Jia H, et al. Palmitoyl acyltransferase Aph2 in cardiac function and the development of cardiomyopathy. Proc Natl Acad Sci U S A. 2015;112:15666-71 pubmed publisher
    ..These findings establish Aph2 as a critical in vivo regulator of cardiac function and reveal roles for protein palmitoylation in the development of other organs including eyes. ..
  70. Cao J, Hawkins E, Brozinick J, Liu X, Zhang H, Burn P, et al. A predominant role of acyl-CoA:monoacylglycerol acyltransferase-2 in dietary fat absorption implicated by tissue distribution, subcellular localization, and up-regulation by high fat diet. J Biol Chem. 2004;279:18878-86 pubmed
    ..Taken together, our data suggest a predominant role of MGAT2 in dietary fat absorption. ..