Camk4

Summary

Gene Symbol: Camk4
Description: calcium/calmodulin-dependent protein kinase IV
Alias: A430110E23Rik, AI666733, CaMKIV, CaMKIV/Gr, D18Bwg0362e, calcium/calmodulin-dependent protein kinase type IV, CAM kinase-GR, Ca2+/calmodulin-dependent protein kinase type IV/Gr, caMK IV
Species: mouse
Products:     Camk4

Top Publications

  1. Enslen H, Sun P, Brickey D, Soderling S, Klamo E, Soderling T. Characterization of Ca2+/calmodulin-dependent protein kinase IV. Role in transcriptional regulation. J Biol Chem. 1994;269:15520-7 pubmed
    ..In addition multiple protein phosphatases, including calcineurin, may exert a modulatory effect on transcription depending on which site they dephosphorylate. ..
  2. Kotera I, Sekimoto T, Miyamoto Y, Saiwaki T, Nagoshi E, Sakagami H, et al. Importin alpha transports CaMKIV to the nucleus without utilizing importin beta. EMBO J. 2005;24:942-51 pubmed
    Ca(2+)/calmodulin-dependent protein kinase type IV (CaMKIV) plays an essential role in the transcriptional activation of cAMP response element-binding protein-mediated signaling pathways...
  3. Illario M, Giardino Torchia M, Sankar U, Ribar T, Galgani M, Vitiello L, et al. Calmodulin-dependent kinase IV links Toll-like receptor 4 signaling with survival pathway of activated dendritic cells. Blood. 2008;111:723-31 pubmed
    ..Here, we identify a role for calcium-calmodulin-dependent kinase IV (CaMKIV) in this survival program...
  4. Ho N, Liauw J, Blaeser F, Wei F, Hanissian S, Muglia L, et al. Impaired synaptic plasticity and cAMP response element-binding protein activation in Ca2+/calmodulin-dependent protein kinase type IV/Gr-deficient mice. J Neurosci. 2000;20:6459-72 pubmed
    The Ca(2+)/calmodulin-dependent protein kinase type IV/Gr (CaMKIV/Gr) is a key effector of neuronal Ca(2+) signaling; its function was analyzed by targeted gene disruption in mice...
  5. Ko S, Chatila T, Zhuo M. Contribution of CaMKIV to injury and fear-induced ultrasonic vocalizations in adult mice. Mol Pain. 2005;1:10 pubmed
    Calcium-calmodulin dependent protein kinase IV (CaMKIV) is a protein kinase that activates the transcription factor CREB...
  6. Wei F, Qiu C, Liauw J, Robinson D, Ho N, Chatila T, et al. Calcium calmodulin-dependent protein kinase IV is required for fear memory. Nat Neurosci. 2002;5:573-9 pubmed
    ..We have found that in CaMKIV(-/-) mice--which are deficient in a component of the calcium calmodulin-dependent protein kinase (CaMK) pathway, a ..
  7. Kang H, Sun L, Atkins C, Soderling T, Wilson M, Tonegawa S. An important role of neural activity-dependent CaMKIV signaling in the consolidation of long-term memory. Cell. 2001;106:771-83 pubmed
    Calcium/calmodulin-dependent protein kinase IV (CaMKIV) has been implicated in the regulation of CRE-dependent transcription...
  8. Wu J, Ribar T, Cummings D, Burton K, McKnight G, Means A. Spermiogenesis and exchange of basic nuclear proteins are impaired in male germ cells lacking Camk4. Nat Genet. 2000;25:448-52 pubmed
    Ca2+/calmodulin-dependent protein kinase IV (Camk4; also known as CaMKIV), a multifunctional serine/threonine protein kinase with limited tissue distribution, has been implicated in transcriptional regulation in lymphocytes, neurons and ..
  9. Shum F, Ko S, Lee Y, Kaang B, Zhuo M. Genetic alteration of anxiety and stress-like behavior in mice lacking CaMKIV. Mol Pain. 2005;1:22 pubmed
    Calcium-calmodulin-dependent protein kinase IV (CaMKIV) phosphorylates the major transcription factor cyclic AMP-response element binding protein (CREB), which plays a role in emotional behavior...

More Information

Publications78

  1. Persaud S, Liu B, Sampaio H, Jones P, Muller D. Calcium/calmodulin-dependent kinase IV controls glucose-induced Irs2 expression in mouse beta cells via activation of cAMP response element-binding protein. Diabetologia. 2011;54:1109-20 pubmed publisher
    ..Our results suggest that the Ca(2+)/CaMK(IV)/CREB cascade plays a critical role in the regulation of Irs2 expression in beta cells. ..
  2. Casanova E, Fehsenfeld S, Greiner E, Stewart A, Schutz G. Conditional mutagenesis of CamKIV. Genesis. 2002;32:161-4 pubmed
  3. Steenland H, Wu V, Fukushima H, Kida S, Zhuo M. CaMKIV over-expression boosts cortical 4-7 Hz oscillations during learning and 1-4 Hz delta oscillations during sleep. Mol Brain. 2010;3:16 pubmed publisher
    ..We show that increasing the expression of calcium/calmodulin dependent protein kinase IV (CaMKIV), a key nucleic protein kinase, selectively enhances 4-7...
  4. Takao K, Tanda K, Nakamura K, Kasahara J, Nakao K, Katsuki M, et al. Comprehensive behavioral analysis of calcium/calmodulin-dependent protein kinase IV knockout mice. PLoS ONE. 2010;5:e9460 pubmed publisher
    Calcium-calmodulin dependent protein kinase IV (CaMKIV) is a protein kinase that activates the transcription factor CREB, the cyclic AMP-response element binding protein...
  5. Ko S, Jia Y, Xu H, Yim S, Jang D, Lee Y, et al. Evidence for a role of CaMKIV in the development of opioid analgesic tolerance. Eur J Neurosci. 2006;23:2158-68 pubmed
    ..in learning, memory and drug addiction, is phosphorylated by calcium-calmodulin-dependent protein kinase IV (CaMKIV)...
  6. Bilbao A, Parkitna J, Engblom D, Perreau Lenz S, Sanchis Segura C, Schneider M, et al. Loss of the Ca2+/calmodulin-dependent protein kinase type IV in dopaminoceptive neurons enhances behavioral effects of cocaine. Proc Natl Acad Sci U S A. 2008;105:17549-54 pubmed publisher
    ..two key regulators of gene expression in response to activity, the Ca(2+)/calmodulin-dependent protein kinase IV (CaMKIV) and its postulated main target, the cAMP-responsive element binding protein (CREB)...
  7. Jones D, Glod J, Wilson Shaw D, Hahn W, Sikela J. cDNA sequence and differential expression of the mouse Ca2+/calmodulin-dependent protein kinase IV gene. FEBS Lett. 1991;289:105-9 pubmed
  8. Wu L, Zhang X, Fukushima H, Zhang F, Wang H, Toyoda H, et al. Genetic enhancement of trace fear memory and cingulate potentiation in mice overexpressing Ca2+/calmodulin-dependent protein kinase IV. Eur J Neurosci. 2008;27:1923-32 pubmed publisher
    ..Previous studies reported that the Ca(2+)/calmodulin-dependent protein kinase IV (CaMKIV) is critical for gene regulation, and behavioral learning and memory...
  9. Hunt C, Parsian A, Kozak C. Genetic mapping of mouse heat shock protein genes Hsc4a to chromosome 11 and Hsc74 to chromosome 18 and two Hsc74 pseudogenes to chromosomes X and 8. Genomics. 1999;56:358-60 pubmed
  10. Ohmae S, Takemoto Kimura S, Okamura M, Adachi Morishima A, Nonaka M, Fuse T, et al. Molecular identification and characterization of a family of kinases with homology to Ca2+/calmodulin-dependent protein kinases I/IV. J Biol Chem. 2006;281:20427-39 pubmed
    ..has so far been available regarding the presence and significance of another predominant CaMK subfamily, the CaMKI/CaMKIV family, in the central nervous system...
  11. Blaeser F, Toppari J, Heikinheimo M, Yan W, Wallace M, Ho N, et al. CaMKIV/Gr is dispensable for spermatogenesis and CREM-regulated transcription in male germ cells. Am J Physiol Endocrinol Metab. 2001;281:E931-7 pubmed
    The calcium/calmodulin-dependent protein kinase type IV/Gr (CaMKIV/Gr) is expressed in male germ cells and spermatids and has been implicated in controlling the differentiation of germ cells into mature spermatozoa...
  12. Wang H, Wu L, Zhang F, Zhuo M. Roles of calcium-stimulated adenylyl cyclase and calmodulin-dependent protein kinase IV in the regulation of FMRP by group I metabotropic glutamate receptors. J Neurosci. 2008;28:4385-97 pubmed publisher
    ..we found that Ca(2+)/calmodulin-stimulated adenylyl cyclase 1 (AC1) and calcium/calmodulin-dependent kinase IV (CaMKIV) contribute to the upregulation of FMRP induced by stimulating group I mGluRs...
  13. Wang H, Fukushima H, Kida S, Zhuo M. Ca2+/calmodulin-dependent protein kinase IV links group I metabotropic glutamate receptors to fragile X mental retardation protein in cingulate cortex. J Biol Chem. 2009;284:18953-62 pubmed publisher
    ..this study we demonstrate that stimulating Group I mGluRs activates Ca(2+)/calmodulin-dependent protein kinase IV (CaMKIV) in ACC neurons...
  14. Wu H, Kanatous S, Thurmond F, Gallardo T, Isotani E, Bassel Duby R, et al. Regulation of mitochondrial biogenesis in skeletal muscle by CaMK. Science. 2002;296:349-52 pubmed
    ..express in skeletal muscle a constitutively active form of calcium/calmodulin-dependent protein kinase IV (CaMKIV*)...
  15. Sikela J, Hahn W. Screening an expression library with a ligand probe: isolation and sequence of a cDNA corresponding to a brain calmodulin-binding protein. Proc Natl Acad Sci U S A. 1987;84:3038-42 pubmed
  16. Sato K, Suematsu A, Nakashima T, Takemoto Kimura S, Aoki K, Morishita Y, et al. Regulation of osteoclast differentiation and function by the CaMK-CREB pathway. Nat Med. 2006;12:1410-6 pubmed
    ..Here we show that the CaMKIV-CREB pathway is crucial for osteoclast differentiation and function...
  17. Akimoto T, Ribar T, Williams R, Yan Z. Skeletal muscle adaptation in response to voluntary running in Ca2+/calmodulin-dependent protein kinase IV-deficient mice. Am J Physiol Cell Physiol. 2004;287:C1311-9 pubmed
    ..Previous experiments in transgenic mice showed that an active form of Ca2+/calmodulin-dependent protein kinase IV (CaMKIV) is capable of stimulating peroxisome proliferator-activated receptor gamma-coactivator 1alpha (PGC-1alpha) gene ..
  18. Moriguchi S, Tagashira H, Sasaki Y, Yeh J, Sakagami H, Narahashi T, et al. CaMKII activity is essential for improvement of memory-related behaviors by chronic rivastigmine treatment. J Neurochem. 2014;128:927-37 pubmed publisher
    ..protein kinase II (CaMKII) autophosphorylation and calcium/calmodulin-dependent protein kinase IV (CaMKIV) phosphorylation in the CA1 region in OBX mice were significantly restored by rivastigmine treatments...
  19. Lee K, Chatila T, Ram R, Thompson R. Impaired memory of eyeblink conditioning in CaMKIV KO mice. Behav Neurosci. 2009;123:438-42 pubmed publisher
    The calcium/calmodulin-dependent protein kinase type IV (CaMKIV) is highly expressed in cerebellar cortical granule cells and deep nuclear neurons in the cerebellum...
  20. Caetano A, Lyons L, Laughlin T, O Brien S, Murray J, Bowling A. Equine synteny mapping of comparative anchor tagged sequences (CATS) from human Chromosome 5. Mamm Genome. 1999;10:1082-4 pubmed
  21. Oury F, Yadav V, Wang Y, Zhou B, Liu X, Guo X, et al. CREB mediates brain serotonin regulation of bone mass through its expression in ventromedial hypothalamic neurons. Genes Dev. 2010;24:2330-42 pubmed publisher
    ..on VMH neurons, serotonin uses a calmodulin kinase (CaMK)-dependent signaling cascade involving CaMKK? and CaMKIV to decrease the sympathetic tone and increase bone mass accrual...
  22. Choi Y, Ann E, Yoon J, Mo J, Kim M, Park H. Calcium/calmodulin-dependent protein kinase IV (CaMKIV) enhances osteoclast differentiation via the up-regulation of Notch1 protein stability. Biochim Biophys Acta. 2013;1833:69-79 pubmed publisher
    ..is promoted by the Notch1 intracellular domain (Notch1-IC) and Ca(2+)/Calmodulin dependent protein kinase IV (CaMKIV) signaling...
  23. Koga T, Hedrich C, Mizui M, Yoshida N, Otomo K, Lieberman L, et al. CaMK4-dependent activation of AKT/mTOR and CREM-? underlies autoimmunity-associated Th17 imbalance. J Clin Invest. 2014;124:2234-45 pubmed publisher
    ..Here, we present evidence that the calcium/calmodulin-dependent protein kinase IV (CaMK4) is increased and required during Th17 cell differentiation...
  24. Koga T, Ichinose K, Mizui M, Crispin J, Tsokos G. Calcium/calmodulin-dependent protein kinase IV suppresses IL-2 production and regulatory T cell activity in lupus. J Immunol. 2012;189:3490-6 pubmed
    The activity of calcium/calmodulin-dependent protein kinase IV (CaMK4) is increased in T cells from patients with systemic lupus erythematosus (SLE) and has been shown to reduce IL-2 production by promoting the effect of the ..
  25. Jin X, O NEILL C. The presence and activation of two essential transcription factors (cAMP response element-binding protein and cAMP-dependent transcription factor ATF1) in the two-cell mouse embryo. Biol Reprod. 2010;82:459-68 pubmed publisher
    ..The study demonstrates a role for trophic signaling and constitutive activation of two essential transcription factors at the time of zygotic genome activation. ..
  26. Song M, Kim H, Park J, Kim S, Kim I, Ryu S, et al. o-GlcNAc transferase is activated by CaMKIV-dependent phosphorylation under potassium chloride-induced depolarization in NG-108-15 cells. Cell Signal. 2008;20:94-104 pubmed
    ..In addition, CaMKIV was found to specifically phosphorylate and activate OGT in vivo and in vitro, which implies that CaMKIV is ..
  27. McKinsey T, Zhang C, Lu J, Olson E. Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation. Nature. 2000;408:106-11 pubmed
  28. Danciger M, Kozak C, Adamson M, Farber D. Chromosomal localization of the murine genes for the alpha- and beta-subunits of calcium/calmodulin-dependent protein kinase II. Mamm Genome. 1992;3:122-5 pubmed
  29. Mock B, Contente S, Kenyon K, Friedman R, Kozak C. The gene for lysyl oxidase maps to mouse chromosome 18. Genomics. 1992;14:822-3 pubmed
  30. Srikanta D, Hole C, Williams M, Khader S, Doering T. RNA Interference Screening Reveals Host CaMK4 as a Regulator of Cryptococcal Uptake and Pathogenesis. Infect Immun. 2017;85: pubmed publisher
    ..Four members of this group significantly and specifically altered cryptococcal uptake; one of them encoded CaMK4, a calcium/calmodulin-dependent protein kinase...
  31. Zhang X, Wheeler D, Tang Y, Guo L, Shapiro R, Ribar T, et al. Calcium/calmodulin-dependent protein kinase (CaMK) IV mediates nucleocytoplasmic shuttling and release of HMGB1 during lipopolysaccharide stimulation of macrophages. J Immunol. 2008;181:5015-23 pubmed
    ..7 cells or murine primary peritoneal Mphi were incubated with either STO609 (a CaMKIV kinase inhibitor), KN93 (a CaMKIV inhibitor), or we utilized cells from which CaMKIV was depleted by RNA ..
  32. Han F, Nakano T, Yamamoto Y, Shioda N, Lu Y, Fukunaga K. Improvement of depressive behaviors by nefiracetam is associated with activation of CaM kinases in olfactory bulbectomized mice. Brain Res. 2009;1265:205-14 pubmed publisher
    ..Increased CREB phosphorylation was associated with activation of CaMKI and CaMKIV as well as CaMKII in these regions...
  33. Jackson K, Sanjakdar S, Chen X, Damaj M. Nicotine reward and affective nicotine withdrawal signs are attenuated in calcium/calmodulin-dependent protein kinase IV knockout mice. PLoS ONE. 2012;7:e51154 pubmed publisher
    ..The calcium activated protein, calcium/calmodulin-dependent protein kinase IV (CaMKIV) phosphorylates the downstream transcription factor cyclic AMP response element binding protein (CREB), which ..
  34. Takemura M, Mishima T, Wang Y, Kasahara J, Fukunaga K, Ohashi K, et al. Ca2+/calmodulin-dependent protein kinase IV-mediated LIM kinase activation is critical for calcium signal-induced neurite outgrowth. J Biol Chem. 2009;284:28554-62 pubmed publisher
    ..An active form of CaMKIV but not CaMKI enhanced Thr-508 phosphorylation of LIMK1 and increased the kinase activity of LIMK1...
  35. Evankovich J, Zhang R, Cardinal J, Zhang L, Chen J, Huang H, et al. Calcium/calmodulin-dependent protein kinase IV limits organ damage in hepatic ischemia-reperfusion injury through induction of autophagy. Am J Physiol Gastrointest Liver Physiol. 2012;303:G189-98 pubmed publisher
    ..In this study, we show that one CaMK member, CaMKIV, is protective in hepatic I/R by activating the prosurvival pathway of autophagy in hepatocytes...
  36. Toyoda H, Zhao M, Mercaldo V, Chen T, Descalzi G, Kida S, et al. Calcium/calmodulin-dependent kinase IV contributes to translation-dependent early synaptic potentiation in the anterior cingulate cortex of adult mice. Mol Brain. 2010;3:27 pubmed publisher
    Calcium/calmodulin-dependent kinase IV (CaMKIV) phosphorylates the major transcription factor, cyclic AMP-responsive element binding protein (CREB), which plays key roles in synaptic plasticity and memory consolidation...
  37. Ribar T, Rodriguiz R, Khiroug L, Wetsel W, Augustine G, Means A. Cerebellar defects in Ca2+/calmodulin kinase IV-deficient mice. J Neurosci. 2000;20:RC107 pubmed
    The Ca(2+)/calmodulin-dependent protein kinase CaMKIV was first identified in the cerebellum and has been implicated in nuclear signaling events that control neuronal growth, differentiation, and plasticity...
  38. Chawla S, Hardingham G, Quinn D, Bading H. CBP: a signal-regulated transcriptional coactivator controlled by nuclear calcium and CaM kinase IV. Science. 1998;281:1505-9 pubmed
    ..These results identify CBP as a signal-regulated transcriptional coactivator and define a regulatory role for nuclear calcium and cAMP in CBP-dependent gene expression. ..
  39. Boyden E, Katoh A, Pyle J, Chatila T, Tsien R, Raymond J. Selective engagement of plasticity mechanisms for motor memory storage. Neuron. 2006;51:823-34 pubmed
    ..In mutant mice lacking Ca(2+)/calmodulin-dependent protein kinase IV (CaMKIV), the maintenance of cerebellar LTD is abolished...
  40. Kitsos C, Sankar U, Illario M, Colomer Font J, Duncan A, Ribar T, et al. Calmodulin-dependent protein kinase IV regulates hematopoietic stem cell maintenance. J Biol Chem. 2005;280:33101-8 pubmed
    ..Here we show that calmodulin-dependent protein kinase IV (CaMKIV) is present in c-Kit+ ScaI+ Lin(-/low) hematopoietic progenitor cells (KLS cells) and that its absence results in ..
  41. Wu J, Ribar T, Means A. Spermatogenesis and the regulation of Ca(2+)-calmodulin-dependent protein kinase IV localization are not dependent on calspermin. Mol Cell Biol. 2001;21:6066-70 pubmed
    Calspermin and Ca(2+)-calmodulin-dependent protein kinase IV (CaMKIV) are two proteins encoded by the Camk4 gene. CaMKIV is found in multiple tissues, including brain, thymus, and testis, while calspermin is restricted to the testis...
  42. Corcoran E, Joseph J, MacDonald J, Kane C, Haystead T, Means A. Proteomic analysis of calcium/calmodulin-dependent protein kinase I and IV in vitro substrates reveals distinct catalytic preferences. J Biol Chem. 2003;278:10516-22 pubmed
    The multifunctional calcium/calmodulin-dependent protein kinases I and IV (CaMKI and CaMKIV) are closely related by primary sequence and predicted to have similar substrate specificities based on peptide studies...
  43. Lazaro J, Bailey P, Lassar A. Cyclin D-cdk4 activity modulates the subnuclear localization and interaction of MEF2 with SRC-family coactivators during skeletal muscle differentiation. Genes Dev. 2002;16:1792-805 pubmed
  44. Wang G, Zhang H, Wang L, Wang Y, Huang H, Sun F. Ca(2+)/Calmodulin-Dependent Protein Kinase IV Promotes Interplay of Proteins in Chromatoid Body of Male Germ Cells. Sci Rep. 2015;5:12126 pubmed publisher
    ..Here, we report that Ca(2+)/calmodulin-dependent protein kinase IV (CaMKIV) accumulates in the chromatoid body by immunofluorescence staining, indicating that CaMKIV is a new component of ..
  45. Ichinose K, Rauen T, Juang Y, Kis Toth K, Mizui M, Koga T, et al. Cutting edge: Calcium/Calmodulin-dependent protein kinase type IV is essential for mesangial cell proliferation and lupus nephritis. J Immunol. 2011;187:5500-4 pubmed publisher
  46. Bordji K, Becerril Ortega J, Nicole O, Buisson A. Activation of extrasynaptic, but not synaptic, NMDA receptors modifies amyloid precursor protein expression pattern and increases amyloid-ß production. J Neurosci. 2010;30:15927-42 pubmed publisher
    ..Altogether, these data suggest that a chronic activation of extrasynaptic NMDAR promotes amyloidogenic KPI-APP expression leading to neuronal A? release, representing a causal risk factor for developing AD...
  47. Zhang X, Howell G, Guo L, Collage R, Loughran P, Zuckerbraun B, et al. CaMKIV-dependent preservation of mTOR expression is required for autophagy during lipopolysaccharide-induced inflammation and acute kidney injury. J Immunol. 2014;193:2405-15 pubmed publisher
    ..In this study, we describe a novel mechanism in which calcium/calmodulin-dependent protein kinase IV (CaMKIV), through inhibitory serine phosphorylation of GSK-3? and inhibition of FBXW7 recruitment, prevents ubiquitin ..
  48. Liu L, McCullough L, Li J. Genetic deletion of calcium/calmodulin-dependent protein kinase kinase β (CaMKK β) or CaMK IV exacerbates stroke outcomes in ovariectomized (OVXed) female mice. BMC Neurosci. 2014;15:118 pubmed publisher
    ..It has recently been suggested that CaMKK and CaMK IV, a downstream target molecule, are neuroprotective in stroke in males...
  49. Park D, Na M, Kim J, Lee U, Cho E, Jang M, et al. Activation of CaMKIV by soluble amyloid-β1-42 impedes trafficking of axonal vesicles and impairs activity-dependent synaptogenesis. Sci Signal. 2017;10: pubmed publisher
    ..This caused an increase in the phosphorylation of Ca2+/calmodulin-dependent protein kinase IV (CaMKIV) and its substrate synapsin, which markedly inhibited SV trafficking along axons between synapses...
  50. Kokubo M, Nishio M, Ribar T, Anderson K, West A, Means A. BDNF-mediated cerebellar granule cell development is impaired in mice null for CaMKK2 or CaMKIV. J Neurosci. 2009;29:8901-13 pubmed publisher
    The Ca(2+)/calmodulin-activated kinases CaMKK2 and CaMKIV are highly expressed in the brain where they play important roles in activating intracellular responses to elevated Ca(2+)...
  51. Taylor D, De Koninck P, Minotti S, Durham H. Manipulation of protein kinases reveals different mechanisms for upregulation of heat shock proteins in motor neurons and non-neuronal cells. Mol Cell Neurosci. 2007;34:20-33 pubmed
    ..However, a constitutively active form of CaMKIV induced robust expression of Hsp70, as well as transcription of a GFP reporter gene driven by the human inducible ..
  52. Lemberger T, Parlato R, Dassesse D, Westphal M, Casanova E, Turiault M, et al. Expression of Cre recombinase in dopaminoceptive neurons. BMC Neurosci. 2007;8:4 pubmed
    ..the patterns of recombination restricted to the major dopaminoceptive regions as seen in the context of the CREB, CaMKIV and GR mutations, the D1Cre line will be a useful tool to dissect the contributions of specific genes to ..
  53. Sikela J, Adamson M, Wilson Shaw D, Kozak C. Genetic mapping of the gene for Ca2+/calmodulin-dependent protein kinase IV (Camk-4) to mouse chromosome 18. Genomics. 1990;8:579-82 pubmed
    ..This raises the possibility that a defect in Camk-4 may be responsible for one of these mutant phenotypes. ..
  54. Mauceri D, Freitag H, Oliveira A, Bengtson C, Bading H. Nuclear calcium-VEGFD signaling controls maintenance of dendrite arborization necessary for memory formation. Neuron. 2011;71:117-30 pubmed publisher
    ..is dependent upon basal neuronal activity and requires nuclear calcium-calmodulin-dependent protein kinase IV (CaMKIV) signaling. Suppression of VEGFD expression in the mouse hippocampus by RNA interference causes memory impairments...
  55. Soderling T. Structure and regulation of calcium/calmodulin-dependent protein kinases II and IV. Biochim Biophys Acta. 1996;1297:131-8 pubmed
  56. Anderson K, Ribar T, Illario M, Means A. Defective survival and activation of thymocytes in transgenic mice expressing a catalytically inactive form of Ca2+/calmodulin-dependent protein kinase IV. Mol Endocrinol. 1997;11:725-37 pubmed
    ..transgenic mice that express a catalytically inactive form of Ca2+/calmodulin-dependent protein kinase IV (CaMKIV) specifically in thymic T cells...
  57. Xiang F, Cui B, Gao Q, Zhang J, Zhang J, Li W. Decreased levels of Ca²?-calmodulin-dependent protein kinase IV in the testis as a contributing factor to reduced fertility in male Crybb2?/? mice. Int J Mol Med. 2012;30:1145-51 pubmed publisher
    ..the decreased Bcl-2 levels, which correlated with the reduction of Ca²?-calmodulin-dependent protein kinase IV (CaMKIV) in the testis...
  58. Wu J, Gonzalez Robayna I, Richards J, Means A. Female fertility is reduced in mice lacking Ca2+/calmodulin-dependent protein kinase IV. Endocrinology. 2000;141:4777-83 pubmed
    Ca2+/calmodulin-dependent protein kinase IV (CaMKIV) is a serine/threonine protein kinase with limited tissue distribution. CaMKIV is highly expressed in the testis, where it is found in transcriptionally inactive elongating spermatids...
  59. Kullmann J, Neumeyer A, Gurniak C, Friauf E, Witke W, Rust M. Profilin1 is required for glial cell adhesion and radial migration of cerebellar granule neurons. EMBO Rep. 2011;13:75-82 pubmed publisher
    ..Our mouse data and the mapping of developmental neuropathies to the chromosomal region of PFN1 suggest a similar function for profilin1 in humans. ..
  60. Tai Y, Feng S, Ge R, Du W, Zhang X, He Z, et al. TRPC6 channels promote dendritic growth via the CaMKIV-CREB pathway. J Cell Sci. 2008;121:2301-7 pubmed publisher
    ..Overexpression of TRPC6 increased phosphorylation of Ca(2+)/calmodulin-dependent kinase IV (CaMKIV) and cAMP-response-element binding protein (CREB) and promoted dendritic growth in hippocampal cultures...
  61. Raman V, Blaeser F, Ho N, Engle D, Williams C, Chatila T. Requirement for Ca2+/calmodulin-dependent kinase type IV/Gr in setting the thymocyte selection threshold. J Immunol. 2001;167:6270-8 pubmed
    ..Ca2+ signals, we examined selection events in mice lacking Ca2+/calmodulin-dependent protein kinase type IV/Gr (CaMKIV/Gr), which is enriched in thymocytes...
  62. Mbebi C, See V, Mercken L, Pradier L, Müller U, Loeffler J. Amyloid precursor protein family-induced neuronal death is mediated by impairment of the neuroprotective calcium/calmodulin protein kinase IV-dependent signaling pathway. J Biol Chem. 2002;277:20979-90 pubmed
    ..These effects were abolished by the G protein inhibitor pertussis toxin, strongly suggesting that APP binding operates via a GTPase-dependent pathway to cause neuronal death. ..
  63. Saino Saito S, Cave J, Akiba Y, Sasaki H, Goto K, Kobayashi K, et al. ER81 and CaMKIV identify anatomically and phenotypically defined subsets of mouse olfactory bulb interneurons. J Comp Neurol. 2007;502:485-96 pubmed
    ..The current study investigated whether calcium/calmodulin-dependent protein kinase IV (CaMKIV) either alone or together with the Ets transcription factor ER81 was necessary for phenotypic determination during ..
  64. Sun L, Cao X, Liu B, Huang H, Wang X, Sui L, et al. CaMK IV phosphorylates prohibitin 2 and regulates prohibitin 2-mediated repression of MEF2 transcription. Cell Signal. 2011;23:1686-90 pubmed publisher
    ..Here we show that Calcium/Calmodulin-dependent kinase IV (CaMK IV) specifically binds to the C terminus of PHB2 and phosphorylates PHB2 at serine 91...
  65. Kwon O, Adamson M, Chin H, Kozak C. Genetic mapping of five mouse genes encoding synaptotagmins. Mamm Genome. 1995;6:880-1 pubmed
  66. Yuan H, Denton K, Liu L, Li X, Benashski S, McCullough L, et al. Nuclear translocation of histone deacetylase 4 induces neuronal death in stroke. Neurobiol Dis. 2016;91:182-93 pubmed publisher
    ..Finally, genetic deletion of calcium/calmodulin-dependent protein kinase IV (CaMKIV) increased the nuclear accumulation of HDAC4 in MCAO model, while overexpression of CaMKIV reduced the levels of ..
  67. Anderson K, Means A. Defective signaling in a subpopulation of CD4(+) T cells in the absence of Ca(2+)/calmodulin-dependent protein kinase IV. Mol Cell Biol. 2002;22:23-9 pubmed
    Ca(2+)/calmodulin-dependent protein kinase IV-deficient (CaMKIV(-/-)) mice have been used to investigate the role of this enzyme in CD4(+) T cells...
  68. Shui B, Xia W, Wen C, Ding X. Jieduquyuziyin prescription suppresses IL-17 production and Th17 activity in MRL/lpr mice by inhibiting expression of Ca(2+)/calmodulin-dependent protein kinase-4. J Nat Med. 2015;69:349-57 pubmed publisher
    ..with JP to ascertain if JP could improve SLE by the suppression of Ca(2+)/calmodulin-dependent protein kinase-4 (CaMK4) expression...
  69. Colomer J, Mao L, Rockman H, Means A. Pressure overload selectively up-regulates Ca2+/calmodulin-dependent protein kinase II in vivo. Mol Endocrinol. 2003;17:183-92 pubmed
    ..However, there are no changes in the levels of CaMKI, which is expressed in the ventricles, or CaMKIV, which is not detectable in the ventricles...